Document n95XOb34BvNnYN9qeLjao387m

SPrimedica Argus Research Laboratories, Inc. 90S Sheehy Drive, Building A Horsham, PA 19044 Telephone: (215) 443-8710 Telefax: (215)443-8587 REPORT AMENDMENT 1 12 OCTOBER 2000 PROTOCOL 418-009 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF N-ETFOSE IN RATS FINAL REPORT Attached is the corrected Text Figure 1 to the above-referenced final report. This change reflects the addition of a notation for the dosage administration of the FI generation rats and did not affect the results of the study. tZ'O C T-0> RajrtWond G. York, P m , DABT Associate Director of Research and Study Director Date O ct DO ^ Nancy J. Gongliewski Date [_J Manager of Regulatory Compliance PROTOCOL 418-009: COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF N-EtFOSE IN RATS Dosing P ttk ri Ends lof Fm m Is Raft (OL 20) Pharmacoklnolic Samptt CoKacbon Sfgioup i Day of Saciifico (OL 21) 418-009:PAGE 1REV1SED PAG: