Document mm3nLGB1nevJBvg5MYVoZy1gb

9 CMA 2/17/98 PAGE 1/7 CMA cw* Chemical Manufacturers Association Vinyl Chloride Health Committee FAX February 17,1998 TO: Dr. James Barter COMPANY: PPG Industries, Inc. Mr. Ed Beeler The GEON Company Mr. Mark Gruenwald Borden, Inc. Dr. Steve Phillips Occidental Chemicals Mr. Caffey Norman Patton Boggs, L.L.P. Dr. Colin Park The Dow Chemical Co. Dr. David Penney CONDEA Vista Company Mr. David Pun Formosa Plastics Mr. Jay Strange Georgia Gulf Corp. PHONE: (412) 434-2801 (440) 930-3030 (614) 225-3459 (972) 404-2413 (202) 457-5270 (517) 636-1159 (281)588-3059 (973) 716-7279 (504) 685-2642 FAX: (412) 434-2137 (440) 930-3034 (614)225-7639 (972) 404-3287 (202) 457-6315 (517) 638-2425 (281) 588-3478 (973) 716-7283 (504) 687-0294 FROM: Wendy K. Sherman CMA (703)741-5639 (703)741-6091 MESSAGE Attached are the records of meeting for October 2,9,1997 and January 8,1998. Please make any comments/changes by next Monday, February 23,1998. The Federal Register Notice announcing the availability of the ATSDR Toxicology Profile mentioned by Caffey Norman was from December 24,1997 (62 FR 67375). The NTIS phone number is 800/553-6847. The NTIS order number for the VC Tox profile is FB98-101132. If you have any questions, please call me at 703/741-5639. Thank you. SENDER: PHONE: PAGE(S) Cynthia Barrett 703/741-5642 7 (including cover) SL 110964 I l Innovation, Technology and Responsible Care* At Work 1300 WusrtN Blvo., Aiuncton, VA 22209 Thepiionc 703-741-5000 * Fax 703-741-fiOOO Cm' TOTAL P.001 CMA 2/17/98 PAGE 2/7 CMA CHEMICAL MANUFACTURERS ASSOCIATION Vinyl Chloride Health Committee Record of Conference Call DATE: TIME: January 8,1998 10:00 a.m. -12 noon B.T. List of Participants: Jim Barter Ed Beeler Mark Gruenwald Bob Hinderer JimKnaak Colin Park David Penney David Pun Jay Strange PPG Industries, Inc. The GEON Company Borden Packaging & Industrial B.F. Goodrich Occidental Chemical Co. The Dow Chemical Company CONDEA Vista Co. Formosa Plastics Georgia Gulf Co. Wendy Sherman Caffey Norman CMA Patton Boggs, L.L.P. Ken Mundt* AEI, Inc. * Denotes part-time attendance. 1.0 Update on the Vinyl Chloride Cohort Study with Applied Epidemiology, Inc K. Mundt briefed the Committee on the status of the study update. The baseline analysis is expected to be conducted within the next 2 to 3 weeks. At the request of K. Mundt, W. Sherman will confer with C. Norman and CHEMSTAR counsel on the process for relaying scientific results to the Committee, consistent with CHEMSTAR Panel guidelines. W. Sherman will circulate for Committee review a copy of a Proposal for a Code of Good Epidemiological Practice (GEPs) co-authored by K. Mundt 2.0 Updateon the University of Louisville Brain Cancer Study W. Sherapan reported that a revised copy of file University of Louisville study protocol was expected within the month from C. Tamburro. W. Sherman will circulate the revised protocol to Committee members. 3.0 Update on the Huntingdon Developmental Study The Committee discussed the draft results from the developmental study and the possibility of submitting an 8(e) report on a decrease in the body weight gain. Although each individual company must make independent decisions related to TSCA 8(e) submissions, C. Norman provided legal counsel to the group regarding TSCA 8(e) compliance. His counsel was based in part on advice given by EPA's TSCA 8(e) SL 110965 CMA 2/17/98 PAGE 3/7 CMA VCHC Record of Conference Call -1/8/98 F*g2 compliance office. C. Norman will summarize this information in a memo that W. Sherman will circulate to the Committee. W. Sherman will forward a copy of the Committee's comments on the draft study to Huntingdon, D. Penney and E. Beeler. W. Sherman reported that ATSDR had granted a request to extend the due date on the final developmental study through the end of January 1998. 4.0 Update on EPA's IRIS Pilot Project C- Norman provided the Committee with an update on EPA's IRIS Pilot Project for vinyl chloride. Data developed during the recent pilot project is currently being entered into the vinyl chloride IRIS database. 5.0 Schedule Next Meeting W. Sherman reminded the Committee that the next VCHC meeting is scheduled for February 10>h. W. Sherman will arrange a meeting location and then notify Committee members. Wendy K. Sherman Manager, Vinyl Chloride Health Committee Subject to Approval SL 110966 CMA 2/17/98 PAGE 4/7 CMA CHEMICAL MANUFACTURERS ASSOCIATION Vinyl Chloride Health Committee Record of Conference Call DATE: TIME: October 2,1997 1230 pjn. -130 p.m. E.T. List of Participants: Ed Beeler Mark Gruenwald JimKnaak David Penney Jay Strange TheGEONCo. Borden Packaging Sc Industrial Occidental Chemical Co. CONDEA Vista Co. Georgia Gulf Co. Wendy Sherman Caffey Norman CMA Patton Boggs, L.LF. 1.0 Discussion of Comments on Section 112(k) of the Clean Air Act The Committee discussed development of comments on the inclusion of vinyl chlorid under section 11200 of the Clean Air Act Members will review company specific information on 1990 TRI data to determine their accuracy. J. Barter will fax TRI data for producers to C. Norman. J. Knaak and E. Beeler will review information on applications for accuracy. 2.0 Schedule Next Conference Call The next conference call is scheduled for October 9*. Wendy K. Sherman Manager, Vinyl Chloride Health Committee Subject to Approval SL 110967 CMA 2/17/98 PAGE 5/7 CMA CHEMICAL MANUFACTURERS ASSOCIATION Vinyl Chloride Health Committee Record of Conference Call DATE: TIME: October 9,1997 10:00 ajil -12 noon E.D.T. List of Participants: Ed Beeler Linda Calhoun Mark Gruenwald Bob Hinderer Jim Knaak Colin Park David Penney Jay Strange Wendy Sherman Caffey Norman Ken Mundt* TheGEONCo. The Dow Chemical Co. Borden Packaging A Industrial B.F. Goodrich Occidental Chemical Co. The Dow Chemical Company CONDEA Vista Co. Georgia Gulf Co. CMA Patton Boggs, L.L.P. AEI, Inc. * Denotes part-time attendance. 1.0 Administrative Items The Panel approved the July 30* Record of Conference Call without changes. The Committee proposed holding a joint meeting with the Vinyl Institute Health and Safety Committee next summer. 2.0 Update on the Vinyl Chloride Cohort Study with Applied Epidemiology/ Inc. K. Mundt briefed die Committee on the status of the study update. New York City has still not provided certificates. Base-line analysis will require separate review and publication. Depending on when remaining death certificates are received, K. Mundt proposed the following updated schedule for the baseline analysis: run analysis in 6 to 8 weeks; draft report in late winter/early spring; and final report in early summer '9$. A one-day j^pe for study reviewers was estimated at approximately $1,000 to $1,500 per reviewwfc Noting that the cost of publication was included in his contract, K. Mundt suggested the American Toumal of Epidemiology as a potential journal for publication of the study. 3.0 Update on the University of Louisville Brain Cancer Study W. Sherman briefed the Committee on the status of die University of Louisville study. SL 110968 CWA 2/17/98 PAGE 6/7 CMA VCHC Record at Conforenc* Call -10/9/97 Page 2 4.0 Update on the Developmental, Reproductive and Mechanistic Research Studies J. Knaak briefed the Committee on the status of the combined developmental and reproductive study at Huntingdon Life Sciences. The in-life portion of the study has been completed, VV. Sherman will circulate a copy of the pre-QA/QC developmental study to the Committee for review in mid-October. E. Beeler will determine if an aliquot from the study canister tank can be kept pending completion of the study, and if there are any additional shipping/handling costs involved in returning the canister. The Committee discussed die September 22nd conference call with J. Swenberg. The group agreed to hold their next meeting in North Carolina in late January/early February. The group discussed assigning a study monitor for this project. W. Sherman will contact Dr. Swenberg and identify potential dates for meeting with the entire Committee at their next meeting. 5.0 Discussion on Updating the PB/PK Model and Revising the VC Risk Assessment The Committee discussed the potential for using J. Swenberg's adduct work in an updated EPA risk assessment for vinyl chloride. The group proposed asking D. Rietz to provide an update on and comparison of various vinyl chloride risk assessments models, including the need for additional work on metabolism to Incorporate adduct information. 6.0 Discussion of Comments on Inclusion of VC in Section U2(k) of the CAA The Committee reviewed the draft comments. Comments are due to EPA October 15*. Any additional information on uses of vinyl chloride and emissions from sources other than chemical plants should be sent directly to C. Norman. 7.0 Update on EPA's IRIS Pilot Project C. Park provided the Committee with an update on his participation as an external reviewer on EPA's IRIS Pilot Project for vinyl chloride. W. Sherman reported that EPA was currently incorporating reviewers' comments, and that the next phase of the project would include a review by an internal EPA committee. 8.0 Update da the EVCM Presentation at Vinyl Institute The Committee reviewed a one-page summary of VCHC activities developed by W. Sherman at the request of the Vinyl Institute. In addition, W. Sherman reported that the VI has asked that the VCHC make plans to present their finalized studies at appropriate industry and scientific forums. In an update on the July 9* meeting with EVCM at VI, W. Sherman noted that no draft study protocols have been received from EVCM for the proposed collaborative studies. SL 110969 CMA 2/17/98 PAGE 7/7 CMA VCHC Record of Conference Cell 10/9/97 Page 3 9.0 Update on the International life Sciences Institute Genotoxicity Project W. Sherman updated the Committee on the progress of the ILSI genotoxicity study. According to the ILSI representative, a draft report on vinyl chloride will probably not be available prior to the end of the year. 10.0 Discussion of VCHC 1998 Final Budget The Committee reviewed and approved the budget proposed on July 30*, including $120,000 for administration costs from August '97 to December '98 (17 months), and $150,000 for the following activities in 1998: molecular research- Swenberg ($75,000), EPA risk assessment ($20,000), outside legal services($15,000) and a contingency ($40,000). 11.0 Schedule Next Conference Call W. Sherman will circulate a calendar to Committee members to schedule the next V^HC conference caU. t'M*****^ Wendy K. Sherman Manager, Vinyl Chloride Health Committee Subject to Approval SL 110970 TOTAL P.006 m