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Material Tested; Material Submitted
AR226-2829
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Haskell L a b o rstoryyUtfoorrn,TrooxxiiccoolloogOyUrSartd inCdumsptar"iyal Medicine
HASKELL LABORATORY REPORT NO. 244-71
""
rganic Chemicals Department 'Jackson Laboratory
Haskell No.; 6917
Procedur
ACUTE ORAL Test
~L
"-s zstz&z
--------- ------------- -------------
-- young adult r ' the livers were removed for gravimetric
Company Sanitized. Does not contain TSCA CBf
Suspension ___ m
25 25 25 25 25
*S
Dose lme/ke)
1 1 ,000t 7,500t 5,000 3,400 2,250
Mortal if-.r*
s - 14 d. s - 14 d. S - 14 d. S - 14 d. s " 14 d.
Weight w Body
301 3i; 352 328 312
Sacrificed ( ) day. ,ftM dosing
tn divided dose
Killed (o) Liver
12 .6 8 14.15 15.65 14.55 13.79
X 100
4.2 4.4 4.4 4.4 4.4
None
> 11 ,0 0 0 mg/kg
W)
-2 -
TEN~DOSE ORAL SUBACUTE TEST
of six young adult C h R - C D ^ L ^ L s ^ f i v r t i m e s 1'7 int" aStric intubation, as a 15% aqueous suspension to a
controls and was intubated with distilled 7 l
fF tW weeksi an additional group of six rats
a 8rUP
appxoximately four hours and 14 days a f t e r t ^ i a s ^ ? 0^ 01 ^
te8t ratS * < - * 8-up ^ e r H L rificed
Results :
Company Sanitized. Does not contain TSCA OR
Dose (mg/kg/davi
Mortality
Weight of Liver (gl
Anlmala Killdr
After
14 Days
After 10th Dose
2250
0 (Control)
0/6 0/6
17.8 18.6 16.8
17.1 13.3 18.1
In spleen, bone marrow pancreas, changes were observed in any of these organs.
L .w. / b .w. x inn
Animals Killed;
After 14 Days
10th
After
Dose 10th Dose
7.8 5.6 8.2 4.8 7.9 4.9
4.2 4.2 3.6
Gross Pathology*
on Liver
Animals Killed;
After 14 Days
10th
After
Pose 10th Dose
111-
on Liver
Animals K M lori-
After 14 Days
10th
After
Dose 10th Dose
B a +,b
B
-
B,C
B B B
B
-
brain eyes, stomach, duodenum, thymus, epididymis, lung and trachea; no compound-related histologic
recovery period, the _________
s r . l. s 2 t f fhe ter phase-
the -- - .
s ac a rate lightly less than that of the controls.
Gross and histopathologic code:
1=
No abnormality detected Large and heavy
A=
B = Reduction^in
U isolated hepatocytes
C = Focal RE cell hyperplasia"^1101*11** cyt0Pla8mic vesicles
Slight degree of change
-3
Summary:
.
its AppnSSmat^L^h^^^^^^^Ur)\ . W acu*-e toxicity when administered orallv
^ u ^ d c. u j
i k coo^ . * * * "
irsr^S
**-- p - ^
test period ,,,d ^ . c tEE i - d k ' ^ L , ' " 0" " " ' " 1 i -
hU tolo*k fffect
Ih" e ',al" "
which are usually found in centrilobt.ery period Was characterized by a depletion of preent at tle end of the
thu^ tin iK ir^ .rs rL -i-s S S = ? S r - - `s-
iVMwuuiuQf
KSC:Pgh Date-' July 20, 1971
)
:
Report f Approved by:
j/, *udC Kathleen S. Carroll Oral Toxicology Section
John fts <japp, Director
