Document jyvkNYO19w9nq8qn87EMMQ2B2
AR226-1307-2
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August 5, 1996
TO: WILLIAM J. VOGLER CR&O HASKELL LAB H-l, ROOM 3S3 NEWARK, OE
FROM: Y. L. POWER, M.D. v w, WASHINGTON WORKS J
C-8 STUDY
Please find attached charts of data developed from reviewing medical records on 51 employees with the highest measured levels of C-8 1n their blood. It would be logical to expect that any disease attributable to C-8
should be found 1n employees with the highest levels of C-8.
In my opinion, very little evidence of disease due to C-8 was found. We did find several employees with frequent elevations of blood tests (SGOT - 7, Alkaline Phosphatase - 10, LDH - 7) but no evidence of liver disease. Perhaps C-8 was the cause of these elevations, but no controlled studies were done. We also found 2 cases of kidney disease and one case of thrombocytopenla/leukopenla that could not be attributable to some other
cause. The significance of these 1s unclear to me.
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Please let me know how we should proceed with this study.
Wn
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YLP:mah T * Attachments Doc. 023412
E ID 107066
0 r . -
000006
C-S SUMMARY OF LAB RESULTS LIVER ENZYMES
Level of C-8 (ppm)
SGOT
Slight Elevation Occasional Frequent
Significant Elevation
Alkaline Phosphatase
Slight Elevation Occasional Frequent
Significant Elevation
LOH
Slight Elevation Occasional Frequent
Significant Elevation
Bilirubin
Slight Elevation Occasional Frequent
Significant Elevation
Employees 1n Study
10+ 5-10 4-5 3-4
31 23 00
S
42 11 01
l2 05 00
L n.
54 32 00
r <
17 02 00
L
51 32 00
S" 5
00 00 00
oo
9 15
l1 00 01
( 2.
16 11
Total
10 7 1
12 10 0
14
7'
0
2 0 1
51 h . o o
Notts:
Slight Elevation: Less than IX noraal lab rtsuits.
occasional: 1-3 abnoraal tasts
Frequent: 4+
*
Significant: Tast rasults greater than IX noraal.
YLPower:aah 8/2/96 Ooc. 023402 (Chart #1)
E I D 107067
000007
C-8 SUMMARY OF LAB RESULTS BIOOO
Level of C-8 (ppm)
10+
5-10
4-5
3-4
Increased WBC
Occasional (1-3)
2
2
4
1
Frequent (4+)
0 2 11
Decreased WBC Occasional Frequent
0002 0002
Anemia - Mild (10-13 g Hgto)
Occasional
Frequent
0 122 0 0 10
Thrombocytopenia
0001
Total
9 4
2 2
5 1 1
RiOOI4I5
YLPower:aah
8/2/96 Doc. 023403 (Chart #2)
E ID 107068 000008
C-8 SUMMARY OF LAB RESULTS KIDNEY
Level of C-8 (ppi)
BUN Slight Elevation Occasional Frequent Significant Elevation
URINALYSIS
-Heaaturla
Occasional Frequent
-Pyuria
Occasional Frequent -AlbuMin
Occasional Frequent
-Casts
10+
1 0 0
1 1
0 0
0 0 1
1-10 4-5 3-4
5 15 0 31 0 00
2 13 1 00 1 32 0 10 4 44 2 00 0 01
Total
12 4 0
*7 2
6 1
12 2 2
Rl 00I4RA
YLP(mer:ah 8/2/96 Ooc. 023404 (Chart #3)
EID107069 000009
SUMMARY OF POSSIBLE DISEASE ANO/Oft SIGNIFICANTLY ELEVATED LABORATORY RESULTS (MORE THAN IX NORMAL)
LIVER
C-8 Level (PP*>
10+ 5-10 4-5 3-4
No. of Employees
0 0 0 2*
a - (I) Significant elevation bilirubin (2-3 mg/OL) on most results. Liver enzyme test normal. No diagnosis established. Most likely Gilbert's Disease. No clinical significance.
(2) Significant elevation SGOT (more than IX normal) on 2 occasions. No diagnosis established.
BLOOO
8 Level (ppm)
10+ 5-10 4-5 3-4
No. of Employees
0 0 0 1
a - Diagnosed thrombocytopenia and leukopenia evaluated by hemotologlst. No etiology found.
(cont.)
EID107070 OOOOIO
HHOO 1H
SUMHARY OF POSSIBLE DISEASE AND/OR SIGNIFICANTLY ELEVATED LABORATORY RESULTS (MORE THAN IX NORMAL!
(cont.)
KIONEY
C-8 Level
(PP*)
10+ 5-10 4-5 3-4
No. of
W w
1 2b 0 1C
a - Definite evidence of kidney disease (casts & hewturla). No diagnosis established.
b - (1) Chronic albuilnurla. Established diagnosis of diabetes. No established diagnosis of diabetic nephropathy but lost likely cause.
(2) Chronic albualnurla. History of high blood sugars. No established diagnosis of diabetes. Diabetic nephropathy lost likely cause.
c - Evidence of kidney disease - casts. No diagnosis established.
R1 00I4RR
YLPower:aah a/2/96
Doc. 023405 (Chart #4)
E ID 107071 000011
