Document jma9K8B0yNzOv5860m3xnn2V9

British Journal of Industrial Medicine 1984:41:25-30 Incidence of cancer among vinyl chloride and polyvinyl chloride workers S STORETVEDT HELDAAS,' S L LANGARD.- AND A ANDERSEN' From the Research Center,' Norsk Hvdro a s Porsgrunn Fabrikker, 3900 Porsgrunn, Telemark Sentralsjukehusd Department of Occupational Medicine, 3900 Porsgrunn, and Cancer Registry of Norway,3 Mon tebello, Oslo 3, Norway. abstract The results of a follow up study of the incidence of cancer and the mortality in a cohort of 454 male workers producing vinyl chloride and polyvinyl chloride are presented. The study population was restricted to employees with more than one year's work experience in the study plant between 1950 and 1969 and the cohort was followed up from 1953 to the end of 1979. Twenty three new cases of cancer were observed compared with 20-2 expected; one case of liver angiosarcoma was found. Five cases of lung cancer were found (2-8 expected) and four cases of malignant melanoma of the skin were observed (0-8 expected). The possibility of a causal rela tionship between exposure to vinyl chloride and the development of malignant melanomas is discussed. Since 1974 when Creech and Johnson presented their report,1 human exposure to vinyl chloride (VC.V1) has been associated with the occurrence of angiosarcoma of the liver. Several studies have confirmed these initial results as reviewed by Spirtas and Kaminski.: In animal studies where VCM was given to mice, rats, and hamsters by different routes of administration neoplasms have also been induced in other organs/ Whether VCM has the potency to induce cancer in man in organs other than the liver has not yet been confirmed. Lung cancer/-1 brain tumours,4-4 and cancer in the digestive system, primarily angiosarcoma of the liver,5 *' have been suggested to be in excess in workers producing VCM and polyvinyl chloride (PVC), and the prime purpose of the present investigation was to study the incidence of cancer in workers exposed to VCM. with special emphasis on cancers other than liver tumours. Material and method tion of VCM and PVC was started in 1950. VCM was produced from acetylene in the room where the polymerisation reactors were located. In 1967 the VCM production was partly altered, and cracking of ethvlenedichloride (EDC) was introduced as one of two production methods. The production of VCM was discontinued in 1971 after which time the plant was operated as a polymerisation unit. From 1955 onwards VCM and PVC were produced in separate rooms; table 1 shows the volume of VCM and PVC production and the number of employees over time. STUDY POPULATION A list containing the names of employees who had started work before the end of 1974 and whose period of employment had exceeded one month was constructed from the personnel register provided by the plant. The health department of the company has kept the health records of all present and previ ous workers employed from 1940 and onwards. These records also contain some information on the place of work of each employee. By combining these PLANT DESCRIPTION The study plant is located in the county of Telemark in south east Norway. In addition to VCM and PVC the company produces fertilisers, magnesium, and chlorine in ad|acent plant complexes. The produc- Received 20 Aunusi 19H2 Accepted 14 October 19K2 Table 1 Annual vinyl chloride and polyvinyl chloride production and number of employees in the study plant Work period VCM (tons) 1950-55 I95b-60 (961-70 ''1971 1000- 2500 2500- 5000 5000-30000 None PVC (tons) No of employees 1000- 2500 2500- 5000 5000-30000 30000-60000 45- 50 45- 90 90-130 120-130 25 SL 101516 26 two sources of information a list of names was con structed which was presumed to be complete. The individual records contained the following informa tion on each worker: full name, date of birth, iden tity number, last known address, dates for beginning and terminating employment, departments in the plant at which each person had worked, and the duration of work in each department. Data were obtained for 1233 workers. It was decided to restrict the analyses to male workers who had been employed for at least one year and who had first been employed at the plant before 1970. These limitations reduced the number ot subjects to 454. estimation of exposure As a consequence of the technical design of the plant and the process operation, the level of expos ure to VCM in the past must have been high but no industrial hygiene survey had been performed before 1974 Estimates of the average atmospheric concentration in the past were based on sporadic measurements that had been carried out with an "explosion-meter" which was graded from 0% to lOODi of the estimated lower explosion limit. 1CT. equivalent to 400 ppm of VCV1. Two sources of supplementary information for estimating the VCM concentration were used: interviews with workers, some of whom had been employed in the plant since the start of production, and a suggested odour threshold of about 500 ppm VCM. Based on this information, we have assumed that the VCM con centration was about 2000 ppm from 1950 to 1954, about 1000 ppm from 1955 to 1959, about 500 ppm from I960 to 1967, and about 100 ppm from 1968 to 1974. During autoclave cleaning the exposure level may have been as high as 3000 ppm.10 Both emulsion PVC and suspension PVC were produced. The surplus monomer in the PVC leaving the man Heldaas, Langard. and Andersen ufacturing plant before 1970 may have contained 500 ppm VCM or even higher concentrations.11 The plant was closed for reconstruction in October 1974 and since 1975 the VCM in the work ing atmosphere has been monitored continuously with automatic measuring devices, including alarm systems that warn the workers during even minor leakages. Since 1975 the VCM exposure level in the production units has been below 1 ppm most of the time. JOB CLASSIFICATIONS Jobs considered to have been associated with high VCM exposure include production, autoclave clean ing. maintenance, and tapping. Owing to the great amounts of surplus monomer in the PVC, one may also assume that the exposure level in the packing unit may have been high until 1970. Those working in the development laboratory which contained small autoclaves in small rooms, in the control laboratory, and at processing in the customers' ser vice laboratory, may also have been heavily exposed, but no information about VCM levels in these working places is available. Nine different exposure categories were defined (table 2), a number of the workers having been employed in more than one exposure category. Membership of an exposure category was defined as that category in which the longest time had been spent. If an indi vidual had been a production worker for some years, and subsequently spent a greater number of years at a job that clearly entailed minimal exposure, he would by definition belong to a low exposure categ ory. As the exposure level was high in the early 1950s, an attempt was also made to classify the jobs as determined by the exposure level, using the number of "years of 500 ppm" exposure. The procedure was as follows: one year of production work in 1951, Table 2 Observed (O t and expected (E) deaths from all causes, and all new cases ofcancer in the studv population except non-melanoma skin cancer Exposure categories ,Vo of tvttrkers 01 Vinyl chloride (acetylene) 02 Vinyl chloride (EDC) 03 Research laboratory 04 Polyvinvl chloride production 05 Autoclave cleaning 06 Maintenance 07 Packing/drying 08 Customers service laboratory 09 Various jobs Total 17 8 48 117 17 44 9S S9 50 4<U All deaths O 1 241 1) (M0 T 4 42 !9 16-42 5 3-04 4 7 64 8 44 7 H-77 7 80 ^0 sy 44 O'E NO NC 0-46 1 16 1 64 0-52 (MU 0-80 0-98 0-84 All cancers OE 0 0-81 [ 0-20 0 1-69 g 5-10 2 103 1 2 87 5 2V5 .4-06 : 2 44 23 20-1 6 OE NC NC NC 1-76 1-04 NO l 69 0-98 0-82 t-14 Person- years /95J-79 m- 5 111)0 9120 2308-5 VN-5 888-0 1742 5 1065-5 971-5 8676-0 'NC - Nut calculated Incidence of cancer among vinyl chloride and polyvinyl chloride workers 27 when the working atmosphere contained about 2000 ppm VCM on average, was classified as four "500 ppm-years." The same type of work m 1961, when the atmosphere was about 500 ppm. would give one 500 ppm-vear. This additional categorisa tion of exposure could be given for VCM produc tion, PVC production, autoclave cleaning, mainte nance work, and PVC packing. Owing to the surplus monomer in the resin, one year of packing PVC would give about one 500 ppm-year for each year up to 1970. and it is even possible that this high level continued until 1974 In this way high exposure for short periods in workers categorised by jobs with low exposure level could be accounted for. All workers were placed in an exposure category before we had any knowledge of their state of health or diagnoses. FOLLOW UP The main element of the method is to identify those individuals who meet the criteria for membership of the study population and to compare this population with a constructed Norwegian population whose age distribution was identical with that of the study group. (The method has been described in more detail by Langird et al.'1) Total mortality and cancer incidence Irom 1953 to the end of 1979 have been determined for the study population. The Cancer Registry in Norway has records of all new cases of cancer since 1953 and has access to information on all causes of death provided by the Central Bureau of Statistics. This study is based on a comparison of observed and expected total mortality and incidence of cancer for the period 1953-79 To estimate the expected number of cases of cancer, the national five year age specific incidence rates were used. According to the data of the Cancer Registry, the rates of cancer incidence in the Telemark county are between 0-90 and 0-95 of the national figures.'1 Consequently, the more rob ust national rates could be used for reference pur- poses and the expected number of deaths are based on the national rates. Results Deaths from ail causes and the number of new cases of cancer, excluding non-melanoma skin cancer, are presented in table 2. The number of person-years at risk is also shown together with a tabulation of the nine different exposure categories. Among 454 men there were 50 deaths from all causes (expected 59-3). During the 27 years of follow up, 23 new cases of cancer were found against 20-2 expected. The nine exposure categories have been combined into three groups reflecting high, medium, and low exposure (table 3); the increased incidence of cancer is accounted for almost entirely by the high exposure group. There was only one liver angiosarcoma, recruited from exposure category 04, and this case has been included in a previous survey.2 Table 3 presents the observed and expected figures for some malignant neoplasms of interest. Five cases of lung cancer were observed in the whole study population compared with 2-8 expected. The mean time between first exposure and the time of diagnosis (latent period) in these five cases was 17-2 years (range 3-26) (not shown in the table). Four of the five cases were in the high exposure group f I-82 expected). Four malignant melanomas of the skin were identified in the study population whereas only 0-8 was expected; three of the cases were observed in the high exposure group (0*5 expected). The tumours were located as follows; two on the trunk, one in the face-neck area, and one on a foot. After the observation period one more case has been diagnosed in the medium exposure group; this was in the face-neck area. We are aware of one case of incipient malignant melanoma located on the trunk Table 3 Broad categories ofwork indicating exposure level. Observed lOl and expected (El deaths from all causes, cases ofcancer (all sites), colon cancer (ICO I S3), bronchial cancer IICD 1621163), malignant melanoma ofthe skin (/CD 190), and cancer of the ilivroid gland IICD 194). For work label, see table 2 Exposure level* Group 2 Group 3 Total No of workers 29? 107 S<) 454 All cancers ICD 153 ICD 162(163 icd ivo (> . OtE O E OiE o E on- o ICD 194 DIE O E Person-vearj 1953-79 0>E IH 12 'db 14 1 3 4-75 0 b u 2 2-44 0-H 0 o-o: VI 4 0-34 NC 0 U- IH NC 1 1 X2 2_2 0-67 NC 1 0-35 NC 0 0-51 5.q 2 o-i a NC 0 0-10 NC 0 0-1 1 1H-2 5727 0 004 NC 1977-5 0-02 NC 971-5 2,1 20- lb II 1 1-44 2-1 5 2`84 1 K 4 0-79 5 1 2 0-16 I2S *676-0 'Group l (high vinvl chloride exposure) - Work, labels 01.02. 04. 05. 0b. 07, Group 2 I medium vinyl chloride exposure) - Work labels 1)3, ON Group 1 (low vinyl chloride exposure) - Work label (to N(' - Sot calculated si* 2K Heldaas. LangArd. and Andersen Tabic 4 Observed (O)and expected fE) cases ofcancer (all sites), king cancer flCD I62/I6J), and malignant melanoma of the skin (/CD 190) in relation to tone of first employment in the plant Years of frst employment ,\o of workers 1950-4 |955_u 1 960-4 1965-9 105 128 ! 21 98 Total 454 \C = Not ojkulaied. Alt cancer? aE 6 7 21 8 6 5| 6 4 33 \ 2-12 23 :<) ib ()`E 08 1-2 1-4 14 08 /CD 161 16,! oE T [()| 3 0-44 0 0 59 1 1/29 i 2 84 OIF. 20 :i NC nc; l8 /CD ivu 0E 1 0-23 l 0-25 2 0* 19 0 012 4 0-79 <)`E NC NC 1 11 NC 5*1 Person^ years 7953-79 2619-0 271 7 0 2093-5 1246*5 8676-0 Table 5 Observed (Of and expected (E) < uses of earner, all utes, of the colon (fCD 153), of the lung (ICD 1621163}, malignant melanoma of the skin (K O !4())t and cancer of the thvrotd gland (!CD 194), bv 500 ppm-vear exposure index \o of 'O0 ppm-\curs' Vo t,t workers All lancers ICD 153 ICD 162 163 ICD WO ICD 194 Person-vears 1953-79 OE (><E a e O E () E ()!E O E O/E <) E OF. *- 1 169 6 7>06 0 8 0 U-M NC 2 1 01 2-0 l 0-29 NC 0 0*06 NC 3074*0 1-5 124 7 * 10 1 0 1 0 21 NC l) 0*40 NC 0 0* 16 NC 0 0 03 NC 2088-5 sS 1b1 14 9-95 1-4 2 0-74 2 7 \ 1 44 2 l 3 0-33 9*1 2 0*06 33-3 3540*5 Total 4M 23 20 lb 1 1 3 1-44 2-1 5 2-84 1-8 4 0*79 5 l 2 0-16 12-5 8676-0 NC - Not calculated, 'For classification ot exposure for these cases see material and methods Fable f Distribution of exposure catenaries among workers in whom cancer has been diagnosed (all cases of cancer), Figures give duration of exposure under different categories m sears hen i ancer iw` diagnosed Pane of first employment Year of diagnosis ICD So* Exposure categories7 01 02 03 04 05 06 07 08 09 63 1962 1979 151 2 hi 1964 1967 151 3 62 1956 1972 153 5 67 1962 1973 153 11 55 1968 1977 153 6 56 1950 1971 155 22 63 1950 1963 162 4 67 1952 1978 162/177 35 58 1955 1977 162/194 54 1958 1977 162 7 11 6 10 10 56 1968 1971 162 29 70 1950 1973 177 2 15 26 1961 1967 178 18 45 1952 1979 181 14 18 1952 1957 190 45f 1953 1981 190 4 2 40 1958 1960 190 4 41 1961 1974 190 4MI 1961 1977 190 13 13 66 1964 1979 190 !4 62 1969 1972 193 3 33 1957 1960 194 11 55 1955 1966 199 2 'IC'D 1 51 (stomach cancer). ICD 153 (colon cancer), ICO 1 5 5 (cancer ot the biharv passages and liver), 1CD 1*2/163 (lung and bronchial cancer). ICD 177 (cancer ot the prostate), ICD 178 (testis cancer). ICD 181 (bladder cancer). ICD 190 (malignant melanoma ot the skin). ICD 194 (cancer ot the thyroid gland) ``Exposure categories corresponding with the numbers in table 2 tfhis case occurred after the end of observation period, ^Incipient case Incidence of cancer among vinyl chloride and polyvinyl chloride workers 29 and diagnosed in 1977 from the medium exposure group. This case has not been included in the study. The latent period for the four cases occurring during the follow up period was 8-8 years (range 2-28) (not shown in table 3). When the two additional cases were included the latent period was 13-1 years. Three cases of colonic cancer were observed in the high exposure group against 0-9 expected. Two cases of cancer in the thyroid gland were observed; both were medullary carcinomas. Table 4 shows the relationship between the date of first employment in the plant and the incidence of all cancers and of some specific tumour sites. We also related the expected chance (risk) of developing cancer to the estimated weighed level of exposure, the 500 ppm-year indicator, and these results are shown in tabic 5. The highest risk ratios were found among those workers who were characterised by high exposure--that is, those accumulating more than five 500 ppm-years. We have no information about the VCM exposure level for the exposure categories 03 and 08 (table 2), which are classified in table 5 under the "less than one" index and which includes workers with less than one 500 ppm-year. It may be assumed, however, that some of these workers were exposed to VCM levels of about 500 ppm. Therefore, the correct exposure category for one of the two cases of lung cancer under the "less than one " index (table 5) could be the "one to five" index. The same may be true for the one malignant melanoma under the "less than one" index. The plant employment history of all workers in whom cancer has been diagnosed and the tumour sites, ranked according to ICD code (7th revision), are presented m table 6. The year of first employ ment and the age when cancer was diagnosed are also included. The previously mentioned latent periods have been calculated from table 6, Discussion The present investigation has shown an increased incidence of malignant melanomas of the skin, lung cancer, colonic cancer, and thyroid cancer in VCM/ PVC workers. Our observation on lung cancers is in accordance with the results of several other studies but to our knowledge, an increased incidence of malignant melanomas in workers producing VCM/ PVC has not been shown before. The present study is one on the incidence of cancer, by contrast with the other investigations which refer to deaths from cancer. If the percentage survival in diagnosed cases of malignant melanoma is high, studies on deaths trom cancer may have masked a possible increased incidence ot this tumour. Waxweiler el al observed 11 deaths trom lung cancer, as compared with 5-7 expected, in VCM workers with at least five years' exposure who also had been observed for 15 years or more after first exposure." They also noted an unusual distribution in the histological type of lung cancer. Of the eight histologically confirmed cases, five were classified as large cell undifferentiated. In our study two of the cases of lung cancer were classified as oat cell car cinomas (small cell undifferentiated). Both occurred in the high exposure group, and both patients had started work before 1-959. As the numbers are small, no conclusions should be drawn, but in Norway,14 as in other countries," only about 20% of all histologi cally classified lung tumours are listed as oat cell or small cell carcinomas. Studies on populations occu pationally exposed to arsenic, asbestos, chromium VI, radiation from uranium, and chloromethylether" indicate that the proportion of oat cell lung cancers in these groups is much higher than expected, and this suggests that attention should be paid to oat cell lung cancer in epidemiological studies on working populations. Buffler et al observed three deaths from lung cancer (0-68 expected) in a subgroup of VCM exposed workers with more than five years' exposure at high exposure level and a long observation period,1 Fox and Collier, on the other hand, could not show an increased risk of lung cancer in members of a cohort recruited from different plants.* They included all exposed workers, laid down no requirements for exposure minimum, and no minimum observation period was accounted for. In the present study the smoking habits of the members of cohort are not completely known. A smoking questionnaire survey in the plant in 1980 showed that 53% of the workers were smokers, by contrast with 42% in the male population in the whole country in the same year.14 Consequently, it does not seem likely that smoking as a confounding factor can explain the differences in the incidence of cancer." Maltoni et al have indicated that VCM is a multipotent carcinogen in mice, rats, and golden hams ters.1 They also showed skin tumours in golden ham sters. some of which were malignant melanomas. In a study of the kinetics and organ distribution of VCM in which rats were exposed to ,4C-VCM by inhalation, Duprat et al showed "a great deal of labelled molecules probably both VCM and its metabolites" in the skin after three hours.11 In a similar study Watnabe et al confirmed these results." None of these authors discussed the significance of the distribution of VCM to the skin, however. Malignant melanoma of the skin is believed to be associated with exposure to sunlight14 and few occu- SL 101520 30 Heldaas. Lan^&rd, and Andersen pations have been associated with the development of these tumours. Tear gas (a-chloroacetophenone) and polychlorinated biphenyls20 are chemicals that have been suggested as possible inducers. In our study population one more case of melanoma has been diagnosed after the closure of the study and before the increased incidence of tumour was known to us. This additional case considerably strengthens the association between exposure to VCM and the development of malignant melanomas. As the medi cal services in the Telemark county have been of a high quality and easily accessible, we do not believe that there has been any bias due to the presence of the occupational health service in the company. In fact, none of the four cases was diagnosed by the occupational physicians. One of the five subjects with skin cancer had survived until June 1982, The incidence of malignant melanomas in the rural areas of Telemark county is slightly higher than the national rate while the incidence in urban areas is fairly equal to the national rate.13 All subjects with skin cancer had lived in the urban area. We observed two cancers of the thyroid gland (0-16 expected): both cases occurred in the high exposure group and were of the same histological type. We are not aware of other studies indicating an excess of this type of cancer but as only two cases have been observed, no conclusions can be drawn. In a Canadian study on workers exposed to VCM for five years or more Theriault and Allard showed an excess of cancer in the digestive system,' but the authors concluded that the excess is accounted for exclusively by cancer of the liver. In the present study we found a slight excess of cancer of the colon. Many of the other studies referred to include cancer of the liver in digestive cancers, and they conclude that the excess risk is due to this tumour. There are few reports on occupationally induced cancer of the colon and rectum although it has been indicated that asbestos workers, textile workers, and steel workers have an increased risk from these diseases.21 Watnabe el al in their kinetic study showed some faecal elimination of l4C after the inhalation of 14C-VCM, but they discuss only urinary and pulmonary elimi nation in their paper '* The results presented in the present study, consi dered with other epidemiological studies, seem to support the view that VCM may act as a multicarcmogen in man. This is in accordance with observa tions from animal studies.3 Some of our findings dif fer from those presented by other workers, and will be followed up later. The observation period is short for some of the members of the cohort, and the study group is small. Nevertheless, the fact that the excess of different cancers was seen in the group with the highest estimated exposure level streng thens the suggested association between VCM exposure and these types of cancers, in particular the malignant melanomas. We thank the Plastic Division of Norsk Hydro a s for cooperation throughout the study. O C Bookman-s critical comments were of great help. We thank. Mrs P A Flor for linguistic help and Mrs U Danielsen for typing the manuscript. References 1 Creech JL, Johnson MN Angiosarcoma of liver in the manufac ture of polyvinyl chloride. JOM 1974,16'lSO-l. 1 Spirtas R. Kaminski R. Angiosarcoma of the liver in vinyl chlonde/polyvinyl chloride workers. 1977 update of the MIOSH register. JOM 1978;20:427-9 2 Mallonl C, Lefemme G, Ciliberti A, Cotti G, Carrerti D. Car cinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis. Environ Health Pertpect 1981:41:3-29 4 Monson RR. Peters JM. Johnson MN Proportional mortality among vinyl-chloride workers. Lancet I974;n,397-8. ' Tabershaw IR. Gaffey WR. Mortality study of workers in the manufacture of vinyl chloride and its polymers. JOM 1974;16:509-18. 4 Waxweiler RJ, Stnnger W, Wagoner JK, Jones J, Falk H. Carter C Neoplastic nsk among workers exposed to vinyl chloride. Ann NY Acad Set 1976:271:40-8, 7 Buffler PA. Wood S. Hitler C, Suarez L, Kilian DJ. Mortality experience of workers in a vinyl chloride monomer production plant.JOM 1979:21.195-202. * Fox AJ, Collier PF. Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain. BrJ Ind Med 1977:34:1-10. ' Theriault G, Allard P. Cancer mortality of a group of Canadian workers exposed to vinyl chlonde monomer. JOM 1981,23.671-6. Barnes AW. Vinyl chlonde and the production of PVC. Proceed ings of the Royal Society of Medicine 1976:69:277-81. " Karstadt M. PVC. health implications and production trends. Environ Health Perspect 1976:17:107-15. 12 Langird S. Andersen Aa, Gylseth B. Incidence of cancer among ferrochromium and ferrosilicon workers. Br J Ind Med 1980:37:114-20. 11 Cancer Registry of Norway. Incidence of cancer in Norway 1972-1976. Oslo: The Norwegian Cancer Society. 1978. 14 Kvile G. Johansen Aa. Lungekreft i Norge: en ovetsiki basert p* Krefttegisterets materiale. Tidsskr Nor Laegeforen 1982:102:480-4. " Wegman OH, Peters JM. Oat cell lung cancer in selected occupa tions: a case-control study. JOM 1978;20:793-6. 14 Axelson O. Aspects on confounding in occupational health epidemiology. Scand J Work Environ Health 1978:4:85-9. 17 Duprat P. Fabry JP, Gradiskr D, Magadur JL. Metabolic approach to industrial poisoning: blood kinetics and distribu tion of l4C-vinylchlonde monomer (VCM). Acta Pharmacol Toxicol 1977.41. suppl 1:142-5. 14 Watanabe PG, McGowan GR, Madrid EO. Gehring PJ, Fate of j ,4C) vinyl chlonde following inhalation exposure in rats. Tox icol Appl Pharmacol 1976:37:49-59. >4 Magnus K Habits of sun exposure and risk of malignant melanoma: an analysis of incidence rates in Norway 19551977 by cohort, sex. age and primary tumor site. Cancer 1981.48:2329-35 24 Sober AJ, Fitzpatnck TB. Genetic and environmental factors of malignant melanoma in man Pigment Ceil 1979:5:88-94 21 Jansson B Colorectal cancer--an occupational disease? Gas troenterology 1978.75 321-3.