Document gajEj6Db9xn3doX1XeVVM3z09

9ndLuZteGJ BIO -TEST Jjik&iaJMusA', 3m. 1810 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 IBT NO. 663-03222 CMA 002033 9ruhJMtid BI O - T E S T laJymJxyuA^, Sac. 1310 FRONTAGE ROAD NORTHBROOK. ILLINOIS 60062 September 23, 1975 Dr. Milton Freifield Project Manager, Vinyl Chloride Research Manufacturing Chemists Association -i--q-j i..;,,2nw-------w-------=.. .1 ySuUc, *>. ,V . -v- itr Washington, D. C. 20009 Dear Mr. Freifield: Re: IBT No. 663-03222 - Chronic Vapor Inhalation Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters We are submitting herewith our laboratory report prepared in connection with the above study. Very truly yours, n J. C. Calandra President ,, a/. J C C:bp CMA 002034 j'sam^'uoI 3 I O - T S S T 2al>o*at&\iei., rmtm 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 13T NO. 663-03222 I. Introduction A chronic vapor inhalation toxicity study with Vinyl Chloride (Ethylene Derived) was initiated on September 10, 1973, and termi nated on September 10, 1974. Animals were then placed on observa tion. A summary of all data obtained through the twenty-third month is reported herein. CMA. 002035 Indu/Ltucil B I O - T S T Una. II. Summary Exposure of mice to Vinyl Chloride was terminated after 9 months of testing. At this time all surviving mice were placed under observation for the remainder of the investigation with the exception of the T-III group (2,500 ppm) which was sacrificed during the eleventh month. Rats and hamsters were exposed to Vinyl Chloride for 12 months before being placed under a non-treated observation period. Respectfully submitted. INDUSTRIAL BIO-TEST LABORATORIES, INC. Report prepared by: .' -.................. Dennis C. Lindb< Assistant to the 1------- B__ Decatur Research Laboratories Report approved by: 'Manager Decatur Research Laboratories Florence K. Kinoshita,/Ph.0T Technical Manager Toxicology Manager, Toxicology Pg CMA 002036 jadudi/uai B I O T S S I JLaJiat\at&ue6, 3 III. Body Weight Data The mean body weight data for albino rats, albino mice and hamsters are presented in Tables I, II and III, respectively. i CMA 02037 Gi mip ik: ri iij 1 111 tit: T1 T 11 t iu T* IV "1 AlJl.ti ) IL.S1" MATLUIA1., Vinyl CiiJurulc (Llliylcnc JJci iu i-d) (.HiiuuiL V-ijiui Julululioti Toxiuly ]5lmly - AIIjiiiu Kai^, AJLliio Mice jih. buhiniary ui Mean liculy W.i^lila Altilnu Hala Mean llu<Jy W. uT> Moult* 1Nuiiitie U i 2 1 4 5 6 J 0 ...I 10 1 1 12 jj I! 15 16 i i tti j? _ 20 21 22 21 205 161 45b 4lJ8 51V 51/ 541 550 55`> 65/ 677 684 652 708 714 764 782 * r) 701 801 8)2 821 />/ 814 204 146 440 4`)l 520 545 554 56? 541 651 640 6/0 646 704 712 75 1 765 11 i /04 748 788 74) 766 760 201 160 45/ 440 522 545 5b? 565 585 601 661 656 716 740 764 786 745 itii 701 781 755 -~ 200 151 451 455 520 500 5b Y 5/6 5111 62? 625 600 718 Y25 764 760 /5U - - ' 160 215 2/5 244 115 120 126 144 156 152 166 180 148 157 424 444 40 i 1/5 441 51) 527 520 527 557 it.t> 212 2/4 247 110 lot* 121 146 167 157 161 174 }04 155 425 448 45H 41*/ 472 484 451 507 480 484 in 242 284 102 111 1)6 125 142 158 168 162 186 |5i 4)4 441 474 462 1 10 450 484 454 - - - 165 240 2U t 101 1)2 12) 125 146 155 155 156 i?4 1/0 420 450 - - -- id I 251 202 2ua 251 114 124 118 148 161 161 104 NA 155 NA 151 421 - --- Chdiii 604 551 - 15? 116 - - - No mine animals I'emdiiNii^ in group. NA - Not dvjiidMe. ! t < i i I % F n o o N> o O00J 4^ ik-x (it UU|) Male 1IC t-i T tl tm 1`clualt' lie f1 t -a T ill i aiiu: n TliiiT MATl'-lllAI,. Vinyl CMoi idu (Klliy 0;iic U^iivi-d J lliionU- Va^m Inhalation Tox icily Slndy - AIL mu Kali, Albino Mice and t^Lleii Hamate: r:> htuittutai y of Mean HLtd y WtriyltL - Albino Mill- Mcjji iiody Weights (^taiua) M 011 ll t N uj it be i'; 0 1 _2_ i 4 6 6 7___ a ___ 'J ____ [0 _ Ji ___ [2 11 ! 4 16 Iti 1 { lb 19 20 2J 22 21 IS 40 41 41 4L 4i 40 62 vi 47 41 47 4b 47 46 40 4 1 11 41 - - - - - n 19 19 4i 44 47 49 47 4/ 4d 4ti 4*J 4b 40 60 40 - - - - - 1U iti 42 44 42 49 4i 44 40 1/ 44 46 - ~ --- 10 id 40 41 44 lb 49 41 41 41 il -'-- u il 16 10 16 10 17 41 40 17 40 40 40 41 42 4U JU 19 19 39 41 39 41 iQ 14 J4 17 19 id 10 41 40 40 47 41 42 41 44 19 1U 2d il 14 16 J? 10 iti 10 40 19 10 40 17 lb 40 lb lb - -'- -- - u il 14 19 10 17 17 14 17 a ---- - --- Change - - 12 - No more annuals ruiMium^ in ^roLi|j. jL X Muiu l`"i m^je Group UC T1 J- it t in in: T-l I IJ 1 111 j A 111.!. XU J L.iT MA'l LJdAI-. Vn*yl (l-Lliy Icitc JleMvt-il) (Jhiuiiit- Viijiui Itih.ijniu>u Tux icily hlutly ' AlliJiui AlLinu Miu dull i - l ! u Smutu.iry ot Miuji llutiy - Gulden llunibluj l. Mc4I) llody lllcl^lll:* (|>i4llla) Monlli Niuiibu , 0 i 2 4 j S 0 7 d s 10 ti n i i n IS 10 1 i id 19 20 71 72 24 71 9 110 120 179 110 UJ no lid m ns 120 176 ni no ns no 1 t i nd 141 111 140 L4i 146 71 90 nil 114 170 171 177 no 126 lid 116 110 IIS Ul n4 122 ns l i>J 117 116 no 117 HI 150 61 B9 S4 *>`1 119 am 120 iia 177 m IIS ns m 176 in 179 io 1 \ m 114 in titito BY ti 91 91 117 no no HS 1 IS 114 110 Ui no n4 no \ 10 127 no - *- n 104 ItiU lid no ni 124 12b no 1 ii no 110 117 ns 122 119 1 IS no ud 117 ni - - - /a Sb 102 in HU j iu 122 no no ns i u 110 j to 116 117 171 122 ns n4 144 no -- 74 *>4 ss iod 107 106 114 in no i id m in ios 114 no 117 122 no \22 176 127 - - - os S2 100 loo 106 104 110 no 105 107 101 99 101 10S 109 117 St - '" Cliaji^e 71 79 - - - No mmc ujiiumk cejujinint; m |*i`otip. I oo O ut K. *T o o o to o o 2mdudhiai B 1 O * T E S T JaJtoftsfou&i.' 2me. 7 IV. Mortality Data The cumulative monthly mortality data are presented in Tables IV through VI. The following is a summary of remaining animal groups: Species Sex Groups Remaining Rats Male Female UC, T-I UC, T-I Mice Female UC -7 *'-1 Male TJC ""-T From mortality data of the past 5 months of observation, the following estimations of death were obtained: Species Rats Mice Hamsters Group and Sex UC-M UC-F T-I-M T-I-F UC-F UC-M T-I-M Estimated Time of Death Months: 5 5 4 1 1 5 3 CMA 002041 'Jndu^i'UaL 3 I 0 * T E S T JlaJuwaiiyuatL, 9nc. 8 Month Number 1 2 t 4 5 6 7 8 9 10 11 12* 13 14 15 16 17 18 19 20 21 22 23 TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Rats Cumulative Number of Mortalities at End of' Month UC T-I T-II T-III MF MF MF MF 000000 0 -0 002010 0 1 n0 1 r> V 00 A,*\ 024130 14 235161 34 3 46 16 1 54 448262 65 4 5 9 3 10 5 10 8 4 6 10 4 11 5 16 15 5 7 11 7 12 9 24 28 7 8 13 9 14 19 34 52 13 14 19 16 21 37 58 66 16 17 23 24 26 50 73 83 19 21 26 30 33 63 85 86 21 23 28 37 40 75 94 89 23 25 31 45 46 87 100(4) 100 28 27 35 53 55 90 100 100 33 28 38 59 64 94 100 100 38 31 43 66 71 94 100 100 46 34 47 73 77 94 100 100 52 42 52 80 100(18) 100(4) 100 100 57 48 63 89 100 100 100 100 64 54 72 92 100 100 100 100 T-IV F 0 0 n 0 0 0 0 1 4 7 17 40 46 76 86 100(7) 100 100 100 100 100 ICO 100 * Includes 5 males and 5 females from each group excluding T-IV sacrificed for cytogenic study. () Indicates moribund or sick animals sacrificed. CMA 002042 Undniii/'uai 3 l 0 * T S S T 2aJ&iatosueA., t 9 Month Number 1 2 *2 - 5 6 7 8 9 10 11 12 13 14 15 16 17 13 19 20 21 22 23 TABLE V TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Mice UC: M Cumulative Number of Mortalities at !End of Month T-I T-:11 F MF MF T-III M F 0 0 0 0 0 0- 0 0 00 030000 f) 6 l3 in 5 1 1'4 -> 4 1 4 7 8 2 26 6 4 2 3 7 12 2 30 6 8 -I 10 9 18 5 31 11 9 12 13 23 18 5 32 14 16 30 30 46 23 8 38 24 37 58 56 75 28 10 42 31 78 82 76 98 30 15 54 46 96 94 100 100 34 16 57 66 98 95 100 100 44 23 70 80 99 97 100 100 54 28 79 91 100 100 100 100 67 39 88 97 100 100 100 100 82 46 100 100 100 100 100 100 82 54 100 100 100 100 100 100 82 58 100 100 100 100 100 no 92 70 100 100 100 100 100 100 100 77 100 100 100 100 100 100 100 81 100 100 100 100 100 100 100 89 100 100 100 100 100 100 100 92 100 100 100 100 100 100 CMA 002043 3 | O T C S T Jaluyia&yu&i, H*tc. Month Number 1 2 T 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE VI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Golden Hamsters UC: M Cumulative Number of Mortalities at End of Month T-I T-II T-III F MF MF M F 5 4 4 4 7 5" 2 5 8 11 10 12 9 16 10 11 i A nJ T -t A~ AU *0 14 13 9 15 16 16 15 19 15 13 9 13 16 16 16 20 15 15 13 18 16 16 20 21 16 16 13 28 24 19 22 33 18 26 14 28 24 19 23 35 19 28 14 29 24 20 25 36 20 28 14 30 26 20 26 37 23 29 15 31 28 21 26 38 28 36 18 36 34 33 37 46 40 45 23 40 43 49 46 49 49 58 28 46 49 58 54 53 61 69 39 61 53 72 66 55 71 84 50 78 58 83 74 59 84 100 57 81 61 85 76 66 86 100 62 85 62 86 77 75 88 100 65 90 68 89 79 84 92 100 71 96 73 95 86 89 100(5) 100 71 100(2) 80 100(3) 100(13) 100(7) 100 100 73 100 82 100 100 100 100 100 78 100 85 100 100 100 100 100 () Indicates moribund or sick animals sacrificed. CMA 002044 UnduAttial 3 1 0 * T E S T J,jJseyuitoAieiL, `Jitc. 11 V. Hematologic Data Twenty-three month hematologic data are presented in Tables VII through X. CMA 002045 TABLE VII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalatio n Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Group Animal Number Untreated Control O !5 O Mo O rf* 1 4 5 7 15 17 18 19 22 27 28 34 37 40 41 42 47 49 52 53 Mean Total Leukocyte Count (thousands/mm Test Month: 23 9-0 11.3 8.7 9.8 13.6 16.0 11.5 14.8 8.0 10.8 15.6 9.7 11.6 15.0 6.6 8.8 7.9 9.2 11.6 10.4 11.0 Erythrocyte Count (millions/ mm 3 ) Test Month: 23 8.03 8.89 8.97 7.30 5.30 6.91 8.52 6.40 7.79 6.57 6.14 8.17 7.88 8.19 7.84 8.55 8.44 6.65 7 .84 8.70 7.65 Hemoglobin Concentration (g/100 ml) Test Month: 23 14.2 16.0 15.6 16.1 11.5 14.6 15.7 14.8 15.2 15.4 14.8 15.2 15.6 16.2 16.0 15-9 17.0 14.0 16.0 16.2 15.3 Hematocrit Value (%) Test Month: 23 48 53 51 50 40 48 54 46 50 50 45 48 52 52 51 50 55 44 50 52 49 cm O H m in -) b* S' 1 r fv Group T-I o > O to t* "0 TABLE VII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats Animal Number 201 207 209 212 214 222 223 225 226 111 228 232 233 234 238 241 246 250 255 268 Me.in Total Leukocyte Count (thousands/mm^) Test Month: 23 9-8 14.6 12.4 12.4 8.7 9.2 10.8 14.8 11.8 5.4 7.6 9.2 10.4 7.3 10.5 12.2 13.7 18.6 6.4 8.7 10.7 Erythrocyte Count (millions/mm^) Test Month: 23 6.54 6.54 3.82 7.26 6.91 6.38 6.44 6.44 7.83 6.57 7.83 7.80 8.19 8.45 7.75 9.37 6.77 7.47 6.95 7.18 7.12 Hemoglobin Concentration (g/100 ml) Test Month: 23 12.4 14.0 8.6 14.4 14.3 13.7 13.8 10.4 15.2 13.7 15.2 14.3 15.8 15.6 15.4 16,4 13.6 14.0 13.8 14.6 14.0 Hematocrit Value (%> Test Month: 23 40 44 30 46 44 42 46 . 38 49 42 47 44 50 49 48 52 41 45 42 44 44 B IO -T E S T I |j* Vi 1--* OJ TABLE Vlll TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Group Animal Number Total Leukocyte Count (thousands/mm 3) Test Month: 23 Erythrocyte Count (millions / mm ^ ) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 Untreated Control n o o o CD 102 105 107 108 111 112 113 117 118 119 121 123 124 125 127 130 131 132 133 134 Mean 13.0 9.1 7.8 15.3 8.3 15.6 10.3 3.6 6.1 11.1 9.0 14.4 10.8 6.1 5.8 20.0 5.0 5.9 8.1 7.0 9.6 5.02 6.78 6.38 7.15 5.29 4.49 5.49 7.26 5.80 5.43 6.10 4.90 6.25 7.27 7.10 2.69 7.18 7.60 6.54 7.30 6.10 12.0 14.9 13.2 14.6 10.4 9.1 12.2 14.6 12.0 12.2 13.6 10.0 13.2 14.8 14.0 5.7 14.6 14.4 13.5 14.4 12.7 40 48 42 46 34 30 38 46 38 38 42 35 40 46 43 22 46 45 42 45 40 1 h |i V $ 4- Group T-I TABLE VIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rat:. Animal Number Total Leukocyte Count (thousands/mm lest Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concen tration (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 315 322 326 337 352 354 363 Mean 9.6 8.4 24.6 9.0 28.4 14.9 5.9 14.4 7.11 6.95 2.01 8.24 6.28 4.42 8.60 6.23 13.2 13.6* 4.4 13.8 10.8 8.8 13.5 11.2 43 43 17 49 36 30 46 38 1 BO o I o o SJ o ui Group Animal Number Untreated Con trol 17 28 40 T-I 250 TABLE IX TEST MATERIAL: Vinyl Chloride (Ethykne Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats tu O m i/t Ring* 5 10 11 Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number: Month Number: Montli Number: Month Number: 23 23 23 23 2 41 52 0 0 52 37 0 0 40 48 1 0 1 0 Basophils Month Number: 23 0 0 0 Jj' i r 10 0 11 79 0 0 0 * Several o the ring-form neutrophils were twisted like a figure 8. n o o to o ui o O'- Vi Group Animal Number Untreated Control 108 112 117 130 T-l 326 352 354 TABLE X TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters OJ O Hematologic Data - Female Rais rn 1/1 Ring* 7 14 7 11 Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Month Number: 23 Lymphocytes Month Number : 23 M onocytes Momh Number: 23 Eosinophils Month Number: 23 1 34 0 52 0 30 1 34 52 5 31 1 63 .0 54 0 1 2 0 0 Basophils Month Number: 23 0 0 0 0 K. Vi * 11 0 35 53 1 0 0 13 0 31 54 1 1 0 90 32 57 2 0 0 * Several ol the ring-form neutrophils were twisted like a figure 8. O o o to orn -J 8 I O T E S T J.aitonatonUi, Jnc. IS VI. Gross Pathology Tables XI, XII and XIII present suspected treatment-related tumors based on iessions found during gross necropsy. These lessions will be evaluated by histopathological examination to determine their true value. Tumor Key C ESC P PMA S 22 A = cannibalized = escaped = postmortem animal = valid evaluation precluded by postmortem autolysis = sacrificed animal - sacriiicad in. extremis = animal still alive CMA 002052 jriduA&ual B 1 0 * T H S T laitvuitoA^in J 19 TABLE XI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Untreated 1 Control 2 7 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 557 530 372 411 504 556 564 532 590 331 656 681 712 609 607 424 645 712 611 402 138 365 146 612 Mortality Data Liver A P A A P A P PMA P PMA PMA PMA P A P A A A P P A P P P SE A A P PMA P D PMA A PMA PMA Spleen Lung Skin Misc. - V X X X X Kidnev CMA 002053 DrtdMdt'uaL B I O - T S T JtaJ&iaioifUe&, !I*c. 20 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 37 Control 38 continued 39 '4') 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 U1 00 A 660 P 360 s A A A 667 SE 702 PMA 524 PMA 619 P A 703 P A 673 P 204 P A A 360 S 360 s 692 P A 641 P 347 PMA 463 PMA 272 P A 456 P A 572 P 581 P 511 P A 360 S 626 P PMA A X X Kidney X X X CMA 002054 jtvluAiual 3 I O - T S 5 T ^aJt&ia&yue.d, jnc. Zi TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 73 A Control 74 599 P continued 75 541 P r o 305 rMrt. 77 675 P 78 A 79 A 80 A 81 A 82 685 P 83 603 P 84 360 S 35 699 P 86 595 P 87 587 P 88 713 PMA 89 384 P 90 302 P 91 706 PMA 92 507 P 93 415 P 94 409 P 95 384 P 96 591 P 97 168 P 98 474 P 99 496 P 100 710 P X X X X X X CMA 305s !)hduiiMal B I O T E S T 2alto*afoue6, Dnc. 22 TABLE XI continue- TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-I 201 A 202 462 P 146 ? )" A 204 668 P 205 361 S X 206 642 P 207 A 208 701 PMA 209 A 210 536 P 211 189 P 212 A 213 703 P X 214 A 215 145 P 216 568 P X 217 599 P X 218 718 P 219 529 P 220 101 PMA 221 541 P 222 A 223 721 P X 224 668 P 225 A 226 A 227 A 228 A 229 675 P 230 74 PMA 231 719 P X 232 A 233 A 234 A 235 324 PMA 236 645 P X X X CMa 02056 ^adudiAiai 3 I O - T E S T J*ahvuti&tie4, jtte. 23 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-I 237 136 PMA continued 238 A 23Q 646 ? 240 261 P 241 722 P 242 693 P 243 669 PMA 244 611 P X 245 595 P 246 A 247 695 P X 248 703 P 249 526 P 250 A 251 A 252 508 P X 253 113 P 254 693 P 255 A 256 361 S X 257 634 PMA 258 34 PMA 259 581 P 260 617 P X 261 624 P 262 275 PMA 263 274 P 264 361 S 265 693 P 266 318 P X 267 662 P X 268 A 269 642 P X Thymus Kidney X X Kidney X CMA 002057 Kidney 270 99 C 271 534 P 272 640 P X Kidney JIndtUtual B I 0 * T E S T ^alttyiaio/Mei, 9e. 24 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung T-I 273 690 P continued 274 661 SE 50 4 o i Jo 158 PMA 277 388 P 278 569 P 279 361 S 280 383 P 281 585 ? 282 A 283 204 P 284 670 P 285 A 286 665 SE 287 547 PMA 288 531 P 289 43 ESC 290 438 P 291 412 ESC 292 A 293 541 P 294 573 P 295 224 P 296 89 PMA 297 94 PMA 298 249 PMA 299 361 S 300 547 P Skin Misc. CMA 002058 Dtidwit'wiL BIO-TEST Jai&ia&ued., 9hc. 25 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lune Skin Misc. T-II 401 495 P X 402 505 P X X 403 626 tu4 361 S 405 474 P X Pancreas 406 534 P XX 407 527 SE X 408 555 P X 409 535 P 410 340 PMA 411 485 PMA X 412 631 S X 413 631 S X 414 506 P X 415 64 P 416 597 P X Mesentery 417 506 P X X 418 631 S X 419 574 P X 420 415 P X 421 604 P X 422 449 PMA 423 108 PMA 424 341 P 425 589 P X 1 426 626 S X X 427 529 PMA 428 626 S X 429 611 P X 430 626 S 431 297 P X 432 317 PMA 433 361 S X CMA 002059 434 617 P X X 435 626 S X 436 626 S X Thymus BIO*TCST jtic. 26 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number T-II 437 continued 438 13 Q 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 Days on Test 478 381 174 626 134 616 451 535 626 576 449 482 501 507 532 626 626 502 452 626 466 526 361 577 333 575 485 626 465 239 547 395 361 224 626 244 Mortality Data Liver Spleen Lun Skin Misc. P PX PMA SX PMA PMA P PMA S PX PX PX X PX PX PMA SX SX PMA PX X SX P PMA SX PMA P XX PMA PMA SX X PX PMA P PX S P sX CMA 002060 P !)hdudixioL B I O - T E S T JtaliaAat&u&t, H*te. 11 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test T-II 473 continued 474 175 476 502 544 229 477 374 478 196 479 590 480 231 481 525 482 569 483 596 484 626 485 468 486 513 487 223 488 223 489 361 490 359 491 626 492 432 493 465 494 612 495 536 496 480 497 446 498 429 499 129 500 480 Mortality Data Liver Spleen Lung PX PX C '_r P P PMA PMA PMA P P P S P P PMA PMA S PMA S P P P PMA P P P P P X X X X X X X X X X X X X X X X Skin Misc. - Prostate Seminal vesic Lymph nodes CMA 002061 jiitludbual 8 I 0 - T S S T JaJtytahueA, 'Inc. 3 28 TABLE XI continued ' TEST MATERIAL: Vinyl Chloride (Ethylene Derived! Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-III 601* 602 603 604 605 606 607 608 609 610 611 612 613 614 615 6161 617 618 619 620 621 622 623 624 625626 627 628 629 630 631 632* 633 634 635 636 355 247 n~O 402 366 242 344 384 361 439 390 236 394 400 411 496 250 498 426 470 371 244 292 362 341 344 353 448 389 424 452 341 341 455 177 392 SE PM A 73 ? P P P P s P P P P P P P p s p p p p p SE SE P P P P P PMA SE P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X Mesentery X X X XX X X X X CMA 2062 ^ncLtd&tial 3 I O - T E S T J.ahHaltyu&L, 9*c. 29 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-III 637 continued 638 639 - 640 641 642 643 644 : 645 646 647 648 649. 650 651' 652 653 654 655 u- 656 657 658 659 660 661 662 663^ 664' 665 666 667 v 668. 669 670 671. 672 405 412 361 459 359 208 293 498 340 373 258 314 402 318 372 386 281 452 343 428 148 427 453 92 299 339 361 373 274 382 383 361 377 366 383 310 P P S P SE PMA P S P P P P SE PMA SE P P P SE P P PMA P P P P S SE P P SE S P o X SE SE X X X X X X X X X X X X X X X X X X X - X Kidney X X Brain Brain X Brain CMA 002063 JItuLabuol B I O - T E 5 T Hhc- IQ TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test T-III 673 continued 674 675 676 677 ' 678 679 680 681 682 r 683 684 685 686 687' 688 689 690 691 692 693 694t 695 696 697 698 699 700 321 335 '^52 342 297 304 428 273 314 296 338 359 374 360 498 443 308 393 413 408 157 361 455 311 364 383 332 143 Mortality Data Liver Spleen Lung P PMA 5 rL p SE P P PMA P SE P P P P S P P PMA P P PMA S P P P P P P X X X X X X X X X X X X X X X X X X X Skin Misc. - X X CMA 002064 Jivi+idiiiaL 3 I O - T S T 2aixyiat&UA, 9*tc. 31 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Untreated 101 Control 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 661 1 6^9 360 513 704 573 673 386 619 575 563 313 557 492 Mortality Data Liver Spleen Lung SE A P A S A A PMA P A A A P P SE A A A p A P A A A PMA A DX. p A A A A A PMA A X Skin X X X X X X X X CMA 002065 B I O - T E S T ^aLonatiyUad,, 9*ic. 32 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Untreated 137 Control 138 continued 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 504 460 612 619 718 452 360 113 715 71 704 656 596 652 360 357 691 616 499 544 129 607 296 698 272 Mortality Data Liver Spleen Lun? Skin A P P A P A A P P A P A S A P P A P P P P A SE S P PMA P P P A PMA PMA P P PMA A T* X X X X X X X X X i\r CMA 002066 ^3 I 0 T E S T jhc. 33 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived! Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 173 169 P Control 174 A *7 *7^ 176 A 177 611 P 178 361 S 179 640 P 180 A 181 660 P 182 A 183 A 184 665 SE X X - X Adrenal glanc 185 616 P 186 669 P 187 A 188 614 P 189 631 P 190 199 PMA 191 A 192 241 PMA 193 461 PMA 194 596 SE 195 A 196 A 197 495 SE 198 699 P 199 531 P 200 361 S X X Adrenal giant X X X X X Adrenal glan CMA 002067 Dtiduit/uaL B I 0 T E S T laJxvuittyti&i., ]*c. ^4- TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin________________ Misc. 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 460 652 361 604 569 174 479 238 651 512 555 595 404 516 283 630 247 41 388 460 641 691 522 718 616 451 614 413 661 617 621 577 656 P SE 5 P P PMA PMA P P P P P P P A P P P PMA P P A P PMA P SE P P P P SE P P P SE X X X X X X X X X X X X Adrenal glan X XX X X X X X X X X X X X X X X X X X X X X CMA 002068 Adrenal gla `Jndui&ual 3 I O * T S T J.aJuyiaiaMeS, 9rtc. 35 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-I 336 continued 337 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 524 --tf . 607 632 180 214 588 760 573 180 116 427 361 466 597 300 540 449 449 531 49 51 547 493 333 454 476 523 428 361 521 277 437 Mortality Data Liver Spleen Lung Skin P A o L. P P PMA P P PM A P PMA PMA P S P P A ? A P PMA P P PMA PMA PMA P A PMA PMA P p P S PMA P.Di. T* kr. X X X X X X X x- X X X X X X X XX X X X X X CMA 002069 Misc. Kidnev 3 1 O - T E S T JiaJi&uitosug, Inc. 36 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-I 373 continued 3 74 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 84 5 So 542 642 381 198 494 419 361 656 513 519 337 356 654 400 283 584 127 556 387 576 593 346 361 703 532 591 Mortality Data Liver Spleen Lung PX P SE P PMA P PMA S SE P P P PMA P PMA P PMA PMA PMA PMA O P PMA S P P P V X X X X X X X X Skin - V X X X X X X X X X X X X Misc. Kidney Uterus Adrenal gl; CMA 002070 D^idndt/ual B I O - T E 5 T 2aJo*3&yu&L, Jhc. 37 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number T-U 501 502 ^'3 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 5 36 537 Days on Test 473 341 471 483 384 360 438 433 327 395 626 348 295 624 377 377 515 208 356 360 143 626 480 361 466 392 364 471 515 420 488 414 389 437 238 509 508 Mortality Data Liver Spleen Lung PMA P p P P P P PMA PMA PMA SE P PMA P P P P P P SE P S P S PMA P P PMA PMA P P P P P PMA P P X X X X X X X X X X X X X X X X X X X X X X X Skin X * X Misc. X X X X Kidney X X /i ac r0V>V CMA 002071 X X Jtulu&fruai B I O - T S T aJia/iat&ue, 9mg. 38 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-II 538 continued 539 5-tO 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 377 316 341 281 306 356 487 428 373 396 303 361 336 335 427 500 461 399 626 496 393 321 314 222 314 452 402 626 366 429 361 443 417 363 416 Mortality Data Liver Spleen Lung PMA PMA ? '> l M_ P P P P P P P P P s PMA P P P PMA P S PMA P P P P P P S P P s p p p p X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. - X Pancreas Thymus X X Kidney X X Adrenal gland X 002072 jrtdndi'Ual 3 I O * T S T JialityiabyiiMd., !Jkc. 39 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mi ce and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test iMortality Data Liver Spleen Lung Skin Mis c. T-II 574 276 P continued 575 325 P X 576 7_i 7 iV 577 345 PMA 578 468 P 579 234 P 580 262 PMA 581 395 P X 582 411 P X 583 309 P X 584 505 P X 585 306 P X 586 429 P X 587 420 P X 588 419 P X 589 402 P X 590 311 PMA 591 311 P X 592 388 PMA 593 387 PMA 594 361 S 595 357 PMA 596 429 P X 597 417 PMA 598 454 P X 599 361 S X 600 335 PMA XX X X X X Lymph nodes X X X X X CMA 002073 D^cLuiiiai 3 I O T E S T ^a^o/iaMyu&L, 9tuz. 40 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-III 701 366 P X 702 262 P ^03 185 n 1 vJ ~t 3 7 i (.iiA 705 443 P 706 373 P X 707 346 P X 708 375 PMA 709 306 SE X 710 240 P 711 333 P X 712 303 PMA 713 261 P X 714 405 P X 715 312 P X 716 353 P X 717 361 S X 718 383 P X 719 405 P X 720 224 P X 721 211 P 722 317 SE X 723 374 P X 724 296 P X 725 438 P X 726 321 P 727 303 ? X 728 361 S 729 381 P 730 443 P X 731 319 PMA 732 361 S X 733 334 SE 734 32 PMA 735 361 S X 736 316 PMA X X X Thymus X Salivary gland X CMA 002074 9ttduifrual 3 I O * T S T Jnc. 41 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. T-III 737 378 PM A continued 738 295 p X 7 39 * 1 1 / a v" 740 362 SE X 741 311 P 742 361 S X 743 325 PMA 744 367 P X 745 351 PMA 746 368 SE X 747 235 P X 748 347 P X 749 379 P X 750 336 P X 751 82 PMA 752 82 PMA 753 377 P X 754 371 P X 755 111 P X 756 348 P X 757 374 P X 758 383 PMA 759 82 PMA 760 320 P X 761 354 SE X 762 256 P X 763 365 P X 764 290 P X 765 322 P 766 311 SE 767 326 SE X 768 311 P X 769 113 PMA 770 268 P X 771 286 P X 772 330 P X X X X Pancrea X X Thymus X X X Kidney CMA 002075 jHGU<diu` aL 3 I 0 T S T JaA&iat&U&i, 9rtc. 42 TABLE XI continued TEST MATERIAL Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspe cted Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-III 773 continued 774 77s 776 777 778 779 780 781 782 783 314 343 284 365 299 325 353 389 322 303 . 784 785 786 787 788 789 790 791 792 793 794 795 796 797 798 799 800 372 283 113 113 113 324 113 401 339 274 271 113 78 78 348 78 78 Mortality Data Liver Spleen Lung P P O ? D c PMA SE P P SE X X Tr A r X X X PMA P PMA PMA PMA P PMA P P P P PMA ESC ESC P ESC ESC X X X X X X X X Skin Misc. - X Salivary gland Cervical lymph nodes Kidney X X CMA. 002076 !}ndu<Utial 3 I 0 * T S S T JaJkyiaiyuai, Inc. 'ii TABLE XI continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Grou Number Days on Test T-IV 2401 2402 U 'tO 0 2404 2405 2406 2407 2408 2409 2410 2411 2412 2413 2414 2415 2416 2417 2418 2419 2420 2421 2422 2423 2424 2425 2426 2427 2428 2429 2430 2431 2432 2433 2434 2435 2436 379 359 311 345 411 405 310 398 434 268 473 349 434 496 261 498 346 351 352 398 498 342 379 434 498 489 457 366 382 297 372 429 311 264 342 484 Mortality Data Liver Spleen Lun? P PMA r1 a * A p p p PMA P P P P P SE P PMA S P P P P s PMA PMA P S P P P P P PMA P P P P P A X X X X X X X x X X X X X X X X X X X X X X X X X X Skin X X X X X X X X X X Misc. Mesenrary Pancreas CMA 002077 jrtdiAit'ual 3 1 0 * T S T JlaluMatoAieA; 9*tc. 44 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test T-IV 2437 continued 2438 385 306 2439 2440 2441 2442 2443 2444 2445 2446 2447 2448 2449 2450 2451 2452 2453 2454 2455 2456 2457 2458 2459 2460 2461 2462 2463 2464 2465 2466 2467 2468 2469 2470 2471 2472 365 394 306 381 473 352 385 385 340 325 370 426 426 365 331 423 220 330 392 375 387 365 498 326 375 318 411 356 365 432 424 361 383 414 Mortality Data Liver Soleen PX SE ? PM A P P P P PMA P P P P PMA P PMA PMA P PMA PMA P P P PMA S SE P PMA P P PMA P DL P PMA P X X X X X X X X X X X X X X X X X X X Lung Skin Misc. - Cervical lymph nodes X Lymph nodes X X X X X X X X X CMA 002078 JHOMiAi/OL aiWM Cl | JLali&U2WU&, UrtC. 45 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Eth/tene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-IV 2473 continued 2474 2 173 2476 2477 2478 2479 2480 2481 2482 2483 2484 2485 2486 2487 2488 2489 2490 2491 2492 2493 2494 2495 2496 2497 2498 2499 2500 447 431 448 469 368 407 417 323 398 316 314 250 348 476 440 344 403 390 379 415 498 355 368 356 285 422 432 P P O Q D PMA PMA P PMA P P PMA SE JQm P P PMA P PMA PMA PMA S P PMA PMA 3E P P X X :: X X X X X X X X X X X X X X X X X Misc. ----------- Ovary Ki i r. e y , j 7 - " ' 4 V- f CMA 002079 jrud^Uuai 3 I 0 - T C 5 T Jzd&iG&yued, jac. 46 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived,) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated Control 801 802 303 804 805 806 807 808 809 810 811 812 813 814 815 816 317 818 819 320 821 822 823 324 825 826 827 828 829 830 831 832 833 834 835 560 429 m 174 428 371 301 429 502 329 452 204 428 197 190 388 505 148 305 474 568 187 94 568 134 418 122 134 321 340 200 570 462 401 94 PMA PMA r\ * . lC\ PMA PMA PMA P P P P P PMA PMA PMA P P PMA PMA P PMA P P P P PMA PMA PMA PMA P PMA PMA PMA p P P CMA 002080 Jndudrual 3 1 0 - T H S T liMonaivu&L, Jhc. 47 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derives, Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test Untreated Control - ----- ,j 836 837 3 39 840 841 842 843 844 845 846 847 848 849 350 851 852 853 354 355 856 857 858 859 860 861 862 863 864 865 866 S67 868 869 370 116 178 " ;s 4Io 388 279 302 213 390 451 390 575 461 271 527 497 441 161 255 255 261 174 564 148 178 178 435 496 272 376 409 564 454 351 349 Mortality Data Liver Spleen Lung PMA P "i \ t i PMA PMA PMA PMA PMA P PMA P P PMA SE PMA P P PMA PMA PMA P PMA PMA P P PMA PMA P PMA P P PMA P SE P X Skin Misc. Kidney CMA 002081 9nc!MdtuaL B I O - T C S T AahoncUoAi&L, !)*& 48 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated Control continued 871 872 3" 2 374 875 876 877 878 879 880 881 882 883 884 885 886 887 888 889 390 891 892 893 894 895 896 897 898 899 900 176 567 ^ t r> 276 152 466 450 371 500 411 431 423 406 380 381 459 292 376 431 275 316 530 94 409 378 262 428 354 277 424 P PMA PS-V f s D PMA P P PMA P P P PMA P P P P P P P PMA P P PMA P P PMA P P PMA PMA CMA 002082 ^HcUd^uai B I O T E S T 2ah*afati*t, 9*c. 58 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated Control 901 902 903 904 905 906 907 908 909 910 911 912 913 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 428 308 345 266 266 390 522 511 511 641 564 616 435 313 564 405 664 325 508 392 571 364 202 579 702 647 511 665 547 669 367 392 511 PMA. P P P P PMA P P PMA PMA A PMA P PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA P P PMA P SE PMA A PMA X 002083 JIndudisual B I O - T E S T 2altavilyu&L, Dnc. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated Control continued 936 937 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 99 209 427 271 582 326 492 511 374 572 511 666 579 709 321 471 440 423 579 551 432 209 371 315 486 672 578 714 450 574 322 575 P PMA P P PMA P P PMA P PMA PMA P PMA A. PMA PMA A P SE A P PMA PMA P PMA P P PMA PMA P PMA P P PMA P Uterus X CMA 002084 Hrududtual B I 0 - T E S T laJxyuiMyueA, Hue. 60 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derivea; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Untreated Control continued 971 972 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 569 449 500 508 526 408 416 526 300 572 405 374 434 500 579 372 667 504 573 452 522 429 94 547 598 666 662 577 439 467 Mortality Data Liver Spleen Lung P P PMA P PMA PMA PMA PMA P PMA PMA P PMA PMA P PMA PMA P PMA P PMA P P P PMA P PMA PMA PMA P Skin - Misc. X CMA 002085 DndudiniaL B I O - T E S T lalxytafoueA, Dm. 49 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 1035 149 445 392 362 492 421 130 309 498 332 79 79 85 85 85 309 378 136 92 290 121 437 121 498 498 367 413 137 332 498 115 346 115 173 281 P P PMA P P P C PMA S PMA C PMA C c c p p c c p c p c s s PMA P P PMA S P P P PMA P Prostate X X Mesentery X X X Mesenteric not X CMA 002086 JndMA&tiaL BIO* f S T aJjQt\ato/ue&r Jhc, 50 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-I 1036 continued 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 407 150 373 196 265 205 275 377 378 123 145 247 149 498 243 389 121 196 118 196 149 145 85 121 346 165 271 121 104 498 121 332 286 434 121 P PMA P P P PMA PMA P P PMA PMA P P S PMA P P P PMA P P PMA C C P PMA PMA C PMA S P P P P C Mesenteric nod* X X X X X X CMA 002087 jHduiS/UaL 8 I O T S T JawtadyueS, Jhc. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-I 1071 continued 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 446 316 294 377 386 386 401 311 319 437 406 362 448 498 432 406 407 407 275 410 267 332 380 293 369 432 386 353 446 365 Mortality Data Liver Spleen Lung P PMA PMA PMA P P P P P P P P PMA S P PMA P P P PMA P P P PMA P P P P P P X X X X X X X X X X X X X X X Skin Misc. Mesenteric nc Kidney Kidney CMA 002088 juduihiai B I O - T E S T J,aboAat&u&U 9*tc, 61 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Number Days on Test 1101 1102 1103 1104 1105 1106 1107 1108 1109 1110 1111 1112 1113 1114 1115 1116 1117 1118 1119 1120 1121 1122 1123 1124 1125 1126 1127 1128 1129 1130 1131 1132 1133 1134 1135 271 435 375 307 338 329 380 359 316 192 354 498 414 368 377 402 264 262 196 374 343 423 323 333 396 249 349 354 462 308 416 329 360 85 382 Mortality Data Liver Spleen Lung Skin Misc. PMA P P P SE PMA P P P P P S P P P P PMA SE P P P P P P PMA PMA P P P PMA PMA P P C P X X X X X X X X X X XX X X X Mesentery XX Kidney X X X Kidney XX X X Mesenteric nodi X X X X Kidney X X Kidney X Uterus X X Kidney X XX X CMA 002089 jncLufrual B I O - T E S T Jalxyiatyu&i, Sue. 62 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number T-I 1136 continued 1137 1138 1139 1140 1141 1142 1143 1144 1145 1146 1147 1148 1149 1150 1151 1152 1153 1154 Days on Test 325 246 187 232 353 340 444 351 236 370 309 398 450 356 429 380 54 388 353 1155 1156 1157 1158 1159 1160 1161 1162 1163 1164 1165 1166 1167 1168 1169 1170 388 260 388 382 294 309 416 416 253 320 347 373 283 380 449 55 Mortality Data Liver P PMA P PMA P SE P P P P P P PMA P P P C P P X X X X X X X Spleen X Luna X X X X X Skin X X X X X X X PMA SE P P P P PMA PMA P P PMA P P P PMA C X X XX X XX X XX CMA 002090 Misc. Mesenteric node Mesepteric node Mesentery Mesentery Mesentery Mesenteric node Kidney Kidney Stomach Mesenteric node 9neL*i&uaL B I O - T E 5 T ^ab&icrfiyu&L, Inc. 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-I 1171 continued 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 55 304 416 355 319 218 428 341 320 341 290 342 295 397 373 284 295 355 343 339 261 305 308 309 247 323 416 123 498 202 Mortality Data Liver Spleen Lung C SE PMA P P PMA P P P P P P P P P PMA P PMA PMA P PMA PMA P P P P PMA PMA S P X X X X X X X X X X X X X X X X Skin Misc. - X X X X Ovary Uterus X Kidney X X Kidney X Kidney, Cervix X X Uterus X Mesenteric nod< Kidney X CMA 002091 'Jududtual 3 I O * T S S T J.aiiamtanie6., Due. 52 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 1201 i o ? i-ii3 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228 1229 1230 1231 1232 1233 1234 1235 320 ?--7 32-1 225 274 296 254 291 275 309 286 331 351 331 322 359 293 318 272 291 226 285 291 225 269 374 299 295 284 310 276 311 290 297 308 P P P P P P P P P SE P SE PMA P P SE P PMA P P P D P P PMA PMA P P P SE P P P X V A X X X X X X X X X X X X X X X X X X X X X X X X X X X X V X Mesentery X X X X X X X X X Mesenteric X X X X Kidney X Lymph noc X X X CMA 002092 9*tdi4&ual B 1 0 * T E S T Jat&ia&yusi, 53 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test T-II 1236 continued 1237 1238 1239 1240 1241 1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 348 340 317 268 292 143 368 303 302 310 389 268 288 300 340 290 258 258 271 282 264 401 292 303 304 287 313 383 244 299 276 249 180 302 303 Mortality Data Liver Spleen Lung P P P P P P P P P P P P PMA PMA P P P PMA P P P P P P PMA P P P P PMA P PMA P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. Kidney Mesenteric noc CMA 002093 UndudiMaL B I O - T E S T JaJkyiaiyusd, 9mc. 54 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 1271 continued 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286 1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 283 258 339 324 317 218 261 273 288 288 265 289 289 286 145 277 248 284 197 305 91 91 255 306 253 214 298 234 294 294 P PMA P P P P P PMA P PMA PMA P P P PMA P P P P P ESC ESC P P P SE PMA P PMA P X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X Misc. Lymph node Kidney Salivary gl, CMA 002094 Hndudi/iiaL 8 I O T E S T 2abonato'tie&, JVto. 64 TABLE XII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number T-II 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 Days on Test 95 259 258 240 290 226 228 296 190 265 231 327 373 214 270 257 278 270 255 333 236 237 316 278 275 277 230 250 218 276 299 222 258 278 278 Mortality Data Liver Spleen Luna P P P P P P P P P P P PMA P PMA PMA P P P P P P P P P P P PMA P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. X X X X Lymph nodes X Mesenteric noc CMA 002095 jndLu&ual B I O - T E S T Ja&anat&tiei, 9*tc. 65 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 1336 continued 1337 1338 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 1362 1363 1364 1365 1366 1367 1368 1369 1370 227 PMA 214 PMA 230 P 305 PMA 275 P 206 P 285 P 179 PMA 270 P 220 P 275 _P 177 P 298 P 261 P 208 P 216 P 315 P 274 P 252 P 271 P 307 P 224 P 241 P 278 P 264 P 245 PMA 259 P 430 P 244 P 310 P 269 P 335 P 287 P 258 P 276 P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X XX X X XX X XX X XX CMA 002096 DndudMaL B I O - T E S T 2aJn*at&iUAy 9}tte. TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-II 1371 continued 1372 1373 1374 1375 1376 1377 1378 1379 - 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 293 316 250 322 322 262 316 234 256 369 278 205 232 275 176 217 340 273 295 251 256 183 272 297 329 498 277 498 212 448 Mortality Data Liver Spleen Lung P P P PMA PMA P P P P P P P P P PMA P P P P PMA P P P P PMA S P S P PMA X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc. - X X Kidney Kidney X X 002097 !}tkLtiinisd. B I O - T E S T laJntaitvuvL. J7*te> 55 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Group Animal Number Days on Test T-IH 1401 1402 1403 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 143 248 276 264 169 93 219 130 208 306 304 312 277 312 221 273 248 280 255 239 237 274 288 220 245 234 274 236 282 127 290 211 291 235 254 Mortality Data Liver Spleen Luna Skin Misc. PMA P P P P C SE PMA P P P S PMA S PMA P SE P P P P P P P P P P P P PMA P P P P SE X X X X X X X X X X X X X X X X X X X X X X X X X - X X X X X X X X X X X X Mesentery X X X X X X X X X X CMA 002098 JtUUiM/U04, OIW* I EJ I ^gfayiril/uujiA^ J*C. 56 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Humber Days on Test T-III 1436 continued 1437 1438 1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 1460 1461 1462 1463 1464 1465 1466 1467 1468 1469 1470 257 121 310 312 258 179 220 121 254 288 287 230 165 108 144 278 311 252 290 295 254 311 267 241 215 258 252 248 274 312 302 255 281 310 277 Mortality Data Liver Spleen Lung P PMA SE S P PMA PMA PMA P P P P PMA PMA PMA P P PMA PMA P PMA P SE P PMA PMA PMA PMA P S P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Kidney Mesentery Kidney CMA 002099 Hndu&tMaL B I O - T G S T JafoiafotiM, Hhc. 57 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-III 1471 continued 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 243 240 241 263 260 302 265 198 226 250 260 287 283 231 224 312 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 266 276 236 229 148 230 306 194 241 312 325 262 221 224 Mortality Data Liver Spleen Lung PMA P P P PMA PMA PMA PMA PMA P PMA PMA P PMA PMA S PMA P PMA P PMA PMA PMA P PMA S PMA P P PMA X X X X X X X X X X X X X X X X X X X X X X Skin Misc. - Mesentery Cervix X CMA 002100 DtttLtdtiUal B I O - T E S T Jlal&iataM&t, 9hg. 67 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 205 225 258 221 206 157 294 229 220 258 272 215 284 283 295 256 302 293 312 263 275 312 222 277 312 312 256 252 265 276 195 179 228 222 210 P P P P P PMA P SE P P PMA P P P P SE PMA PMA S P P S P P S S SE P P P P P P SE P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X Mesentery X X X XX XX XX X X X X X X X XX X CMA 002101 Dtulud^UaL B I O - T E S T Jabonat&ufA, Hhc. 68 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-IU 1536 continued 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 276 263 178 227 232 247 253 208 208 312 208 276 263 276 260 282 295 269 267 224 254 278 273 261 275 294 180 235 298 1565 1566 1567 1568 1569 1570 206 240 220 309 191 312 Mortality Data Liver Spleen Lung P PMA P P P P P SE S s p p p p PMA PMA P P PMA P SE P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X P PMA P P P s X X X X X X X X Skin - X X X X X X X CMA 002102 Misc. Mesentery Ovary Kidney Ureter Mesentery Ovary Dttdui^uai B I O T S T JjaAouxtowi, 69 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice* Animal Group Number Days on Test T-III 1571 continued 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 265 257 255 194 221 243 212 250 269 273 259 290 272 299 295 239 239 197 264 248 226 113 202 240 236 118 240 Mortality Data Liver Spleen Lung P P SE P P P SE SE P PMA PMA P P P PMA PMA P P PMA P P PMA P P PMA PMA P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin - X X X 1598 1599 1600 190 268 264 P SE P X X XX XX X Misc. Salivary glands 03 *03 B I O - T E S T Jta&oAaL&uU, Hue. TABLE XIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1601 Control 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 447 591 591 452 529 492 596 565 591 64 8 697 46 649 536 698 107 107 44 186 151 83 51 96 54 A PMA rn p p PMA p SE P A P A A PMA A A C P C A A P P A P A PMA PMA PMA PMA PMA PMA C PMA C CMA 002104 DnduA&ual B I O - T E S T 2abviabiM*&, Uttc. 71 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1636 Control 1637 continued 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 99 99 136 207 199 199 40 66 123 123 88 201 177 157 541 363 157 395 61 2 169 688 2 14 524 591 55 14 363 11 576 519 708 PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA A P PMA C P P C PMA A P P PMA C P C P PMA P CMA 002105 Jladudteal B I O - T E S T 72 TABLE XIII continuec TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Untreated 1671 Control 1672 continued 1673 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 695 243 701 686 479 593 436 575 325 511 651 246 108 108 529 430 530 467 319 503 121 303 P P A A A P P PMA P P A P A A PMA P P PMA PMA PMA P P A P P PMA P P A PMA Skin . Misc. CMA 002106 Snd&it'ual B 1 O - T E S T Jabyvaiyu&t, 9he. 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test T-I 1801 1802 1303 666 1804 61 1805 59 1806 85 1807 44 1808 382 1809 371 1810 589 1811 100 1812 100 1813 533 1814 575 1815 622 1816 631 1817 137 1818 191 1819 148 1820 100 1821 65 1822 164 1823 111 1824 175 1825 607 1826 523 1827 51 1828 375 1829 649 1830 1831 607 1832 377 1833 108 1834 108 1835 108 1836 108 Mortality Data Liver Spleen Lung A A P C C P PMA P P P PMA PMA P P P P PMA PMA PMA PMA PMA PMA PMA PMA P PMA C PMA P A P PMA PMA PMA PMA PMA X X. X X Skin - Misc. Kidney Lymph nod Kidney Kidney Kidney X 0021O'7 ^ndiUtUaL B 1 O - T E S T ^akyvai&uai, Due. 74 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin_______________ Misc. T-I 1837 continued 1838 1839 1840 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 614 108 4 696 386 14 64 420 373 635 47 47 47 572 574 531 72 248 77 94 109 141 196 101 632 206 206 206 206 312 570 202 55 P PMA A C A PMA P C PMA PMA PMA P PMA PMA C P P P C PMA PMA PMA PMA PMA P PMA S PMA PMA PMA PMA P PMA A PMA PMA X X X X X Kidney 002103 JndiufrUal B I O - T S T 2a&o*ato*ie&, 9*tc. 75 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Ueriveu; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-I 1873 64 PMA continued 1874 24 C 1875 485 P X 1876 29 C 1877 460 P XX Kidney 1878 684 P 1879 1880 684 A P 1881 A 1882 711 P X Kidney 1883 611 P X 1884 A 1885 A 1886 . 279 P 1887 555 P 1888 597 P X 1889 616 P X 1890 A 1891 45 C 1892 45 C 1893 576 P 1894 587 P 1895 310 SE 1896 A 1897 289 PMA 1898 A 1899 347 PMA 1900 A CMA 002109 B I O - T E S T aJtyiaiyue&, 76 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derive, Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin_______________ Misc. 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 107 36 298 201 101 162 86 95 113 48 24 6 109 48 424 632 100 203 40 186 129 83 61 111 100 100 100 100 100 594 100 100 632 632 590 589 PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA S PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA S S P P 2ll0 9*un4&ual B I O - T E S T lalxyxattvued., 9*c. 77 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-H 2037 continued 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052 2053 2054 2055 2056 2057 2058 2059 2060 2061 2062 2063 2064 2065 2066 2067 2068 2069 2070 2071 2072 632 90 370 238 208 225 107 64 238 85 288 486 46 249 415 561 532 632 244 576 588 9 10 41 33 9 12 221 221 7 10 632 171 391 108 108 S C P P PMA P PMA PMA P C PMA P C P P P P S P P P c PMA PMA PMA C PMA PMA PMA C C S P P PMA PMA X X X X W3--v*-y** Kidney X CMA 0021H 9ndudUiai B I O - T E S T laltaiViioMei, !}xc. 78 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived! Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin T-II 2073 continued 2074 2075 2076 2077 2078 2079 2080 2081 2082 2083 2084 2085 2086 2087 2088 2089 2090 2091 2092 2093 2094 2095 2096 2097 2098 2099 2100 632 469 44 632 7 632 101 101 127 632 93 632 107 100 44 158 44 590 582 632 632 9 388 32 528 535 632 99 S P C C PMA PMA PMA P S c S PMA PMA PMA PMA PMA P P S S C P C P P s p XX XX XX X X XX X Misc. Kidney IjHtlui&ual B I O - T E 5 T 2al&uai&U6&, $'hc. 79 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality Test ______ Data Liver Spleen Lung Skin Misc. T-III 2201 348 P X 2202 54 C 2203 405 P X 2204 192 PMA 2205 219 P X 2206 434 P X 2207 231 PMA 2208 101 P 2209 206 PMA 2210 417 P X 2211 350 P X 2212 108 PMA 2213 367 PMA 2214 422 P XXX 2215 582 P XX 2216 179 P 2217 552 P X 2218 422 PMA 2219 219 PMA 2220 196 P 2221 386 PMA 2222 346 P X 2223 346 PMA 2224 346 PMA 2225 496 P X 2226 365 SE X 2227 100 P 2228 305 PMA 2229 2230 330 441 P P X X X 2231 377 P X 2232 189 P 2233 422 P 2234 340 P 2235 16 C Pancreas Thymus CMA 002113 JaduibuoL B I O - T E 5 T Ja&otafoUeS, 80 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Denvea; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test T-IH 2236 continued 2237 2238 2239 2240 2241 2242 2243 2244 2245 2246 2247 2248 2249 2250 2251 2252 2253 2254 2255 2256 2257 2258 2259 2260 2261 2262 2263 2264 2265 2266 2267 2268 2269 2270 339 591 529 478 270 517 590 591 100 477 484 139 404 147 373 46 137 149 278 295 361 395 547 591 591 508 46 408 474 270 373 372 39 176 351 Mortality Data Liver P S p PMA PMA P P PMA PMA P P PMA P PMA P C P P P P PMA P PMA S S SE C P PMA PMA P PMA C PMA P X X X X X X X X X X X X X X X X X Skin Misc. Kidney CMA 002H4 JtuhtAtual B I O - T E S T abwaton*e&, 81 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test T-IH 2271 continued 2272 2273 2274 2275 2276 2277 2278 2279 2280 2281 2282 2283 2284 2285 2286 2287 2238 2289 2290 2291 2292 2293 2294 2295 2296 2297 2298 2299 2300 , 324 54 338 411 591 569 323 155 85 85 85 64 85 64 385 286 26 360 330 448 438 438 326 359 591 211 285 38 155 99 Mortality Data Liver P C P P S PMA SE PMA ESC ESC ESC ESC ESC ESC P P C P PMA P PMA P PMA PMA S PMA PMA C PMA PMA X X X X X X Skin X X Misc. Kidney Mesentery 3lis Sthdudbial B I O - T E 5 T Jaicvuzt&ti*L, Jk& 32 TABLE XIII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived! Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1701 Control 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 632 632 23 43 414 426 559 108 95 137 95 7 7 68 104 116 137 505 591 629 495 130 589 404 91 131 128 410 127 127 454 23 70 104 271 S S C PMA P P P PMA PMA PMA PMA C PMA PMA PMA P PMA P P P P PMA P P PMA PMA PMA PMA PMA PMA P PMA C PMA PMA X Kidney CMA 002116 JIndudiMal B I O - T E S T 2alnnaiatM&, H*tc. 83 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1736 Control 1737 continued 1738 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770 1771 1772 411 103 411 97 611 168 351 79 415 52 54 592 530 118 186 65 30 233 53 194 373 59 595 208 147 147 89 307 53 582 541 567 575 47 367 116 116 PMA PMA PMA PMA P PMA PMA C P C C P P PMA P PMA C PMA C PMA PMA PMA P PMA PMA PMA PMA PMA C PMA P P P C PMA PMA PMA CMA 002117 jttdadiual B 1 O - T E S T 2aJtyuittyUaA, 9*c. 84 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived; Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1773 Control 1774 continued 1775 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 193 P 198 P 249 P 267 PMA 283 . PMA 114 PMA 190 PMA 362 PMA 340 PMA 314 PMA 38 C 200 P 587 P 27 PMA 341 PMA 43 C 571 P 464 P 193 PMA 435 P 14 C 400 PMA 542 P 536 P 506 P 539 P 547 P 531 PMA X X CMA 002118 JIneLtd&Ual B I O - T E 5 T J.alttyicitotetA, 9*c, TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 104 187 188 141 394 153 200 57 84 200 113 201 108 120 131 164 580 49 49 131 106 311 119 119 119 133 61 52 127 572 578 94 81 74 126 191 PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA P PMA PMA PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA Kidney X CMA 002119 9*tdiUbtfal B I O - T E S T JaAa*aivUa&, Hue. 86 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-I 1937 continued 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 191 180 185 66 473 553 417 54 493 435 451 608 47 53 83 467 476 313 47 51 59 578 632 544 632 40 56 86 174 33 31 107 178 592 397 411 Mortality Data Liver Spleen Lung PMA PMA PMA PMA P P PMA C P P P P C C PMA P PMA PMA C PMA C P S P S ESC PMA C PMA C C PMA PMA P PMA P X X X X X X Skin - Misc. Ovaries CMA 002120 ^ndusUiai B I O - T E S T 9tvs. 87 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-I 1973 continued 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 524 14 467 31 371 487 86 577 581 494 424 542 94 128 207 193 65 389 55 488 493 24 191 632 33 144 603 88 Mortality Data Liver Spleen Lung P C P C P P PMA P P P P P PMA PMA PMA PMA PMA PMA C P P c p s PMA PMA P ESC X Skin X Misc. Ovaries Ovaries CMA 002121 ^tuJUtfdfUaL B I O - T E S T Ja&tvtafoUei, 9*c. 88 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 2101 2102 2103 2104 2105 2106 2107 2108 2109 2110 2111 2112 2113 2114 2115 2116 2117 2118 2119 2120 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 602 9 486 545 476 553 451 392 514 578 570 336 52 476 632 529 52 632 87 60 39 509 632 39 446 221 562 576 286 513 129 495 173 208 447 413 P C P P PMA P P P P P P PMA C P S P C S C c ESC PMA S ESC P P P P P P PMA P PMA P P PMA X X X X X X X X Kidney Kidney X Mesentery X X X Cervix X CMA 002122 Dmludi^iai B I O - T E S T Dhc. 39 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Skin Misc. T-II 2137 continued 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 2155 2156 2157 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170 2171 2172 29 47 359 29 39 522 68 36 36 522 104 603 46 628 426 307 632 614 207 542 632 564 614 473 96 96 96 534 541 200 485 196 468 632 409 383 C C PMA C C P c c c p PMA P C P P PMA S P P P S P P PMA PMA PMA PMA PMA P P P P P S P P X X X X X X Thymus Ovaries CMA 002123 9*uLabual B I O - T E S T Htte, 90 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-II 2173 continued 2174 2175 2176 2177 2178 2179 2180 2181 2182 2183 2184 2185 2186 2187 2188 2189 2190 2191 2192 2193 2194 2195 2196 2197 2198 2199 2200 456 489 541 466 462 492 53 566 570 9 514 520 202 470 261 212 194 245 541 536 29 193 508 625 596 632 558 547 Mortality Data Liver Spleen Lung_ P P P PX SE X X P C P P C p XX p PMA P PMA PMA P PMA P X X P C PMA SE X PX P S XX P XX PX Skin - X X X X Misc. Kidney Cervix Ovaries CMA 02124 9ndb*it?ual B I O - T E S T JaianaiyUei, Stic. 91 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test T-IH 2301 2302 2303 2304 2305 2306 2307 2308 2309 2310 2311 2312 2313 2314 2315 2316 2317 2318 2319 2320 2321 2322 2323 2324 2325 2326 2327 2328 2329 2330 2331 2332 2333 2334 2335 9 74 149 591 320 309 314 304 201 118 206 201 390 64 247 300 318 315 249 207 360 381 403 361 350 498 390 354 448 354 398 498 496 411 89 Mortality Data Liver Spleen Lung C PMA C S P PMA PMA C C PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA P P P S P P P P PMA S P PMA C X X X X X X X X X X Skin Misc, X 00212$ CtAA Undudfrual B I 0 - T E S T 2abanat&u*<U Una. X \ 92 A. A w TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number T-ni 2336 continued 2337 2338 2339 2340 2341 2342 2343 2344 2345 2346 2347 2348 2349 2350 2351 2352 2353 2354 2355 2356 2357 2358 2359 2360 2361 2362 2363 2364 2365 2366 2367 2368 2369 2370 Days on Test 442 405 399 87 409 490 219 286 403 332 419 403 8 41 54 96 118 244 359 8 353 48 385 207 352 96 100 96 96 96 96 305 439 591 407 Mortality Data Liver Spleen Lung Skin Misc. P PMA P C P P PMA P P PMA PMA PMA C PMA C PMA PMA PMA P C SE C P PMA P PMA PMA PMA PMA PMA PMA PMA PMA P PMA X X X X XXX X X XX Stomach X CMA 002126 ^nduituai B 1 0 T S S T Ja&MafotM, 9nc. TABLE XIII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats. Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-HI 2371 continued 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2384 2385 2386 2387 2388 2389 2390 2391 2392 2393 2394 2395 2396 2397 2398 `2399 2400 367 383 390 379 61 68 53 264 ,207 ~ 49 38 279 ,279 306 .'378 387 .364 .207 " 194 (325 38 364 29 243 361 29 41 84 397 .208 PMA PMA PMA PMA PMA PMA C PMA PMA PMA ESC PMA PMA PMA P P PMA PMA PMA P C P C P PMA C C PMA PMA PMA X X X X Misc. CMA 002127