Document gadk0N4eaZdOVGGgEEbNgeMrq

f iX b c H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revision No. 1 Volume 3 of 5 Revised Page DuPont-5386 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100(1998) Author: Gregory S. Ladies, Ph.D., D.A.B.T. Original Completed on: December 3, 2001 Revision No. 1 Completed on: April 5, 2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number:, (0*1Service Code Number: Sponsor Study Number: \ Company Sanitized. Does not contain T S C A CBI H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX E INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Company Sanitized. Does not contain T S C A CBI 630 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA EXPLANATORY NOTES Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed and are reported as "removed from study" in this appendix. Clinical Observations recorded during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 80 Ophthalmology examinations were conducted on rats designated for the 90day exposure period and the one-month recovery period. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for the 90-day exposure period were sacrificed. Day 122 Ophthalmology examinations were conducted on rats designated for the onemonth recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed. Day 181 Male and female rats designated for the 3-month recovery period were sacrificed. Any clinical sign observed on consecutive data collection days is assumed to have been present during the interim between observation days, and will be reported as having been observed over the period from the first-last day observed. Ophthalmology Evaluation observations and Clinical Pathology Evaluations are documented as Clinical Observations and interrupt the continuing clinical observations. All ophthalmology observations from test days 80 or 122 are those observed during the examination by the veterinary ophthalmologist. Company Sanitized. Does not contain TSCACBI 631 ) )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 643241 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91 91 44 80 91 MT 643300 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643143 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Wound, Superficial, Shoulder, Right Sacrificed by design 0-28 44,91 80 35-42,49-77,84-91 91 MT 643205 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643235 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643288 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643150 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 M 643189 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 MI 643185 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 91 44 80 91 Company Sanitized. Does not contain T S C A CB! 632 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 643210 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,35-49,84,90,98,105,112,119, 140-154,161-181 55,101 9,96,108,139,160,181 0-3,21,34,76,89,92,115,125 56-70,77,126-133 181 MI 643268 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Discharge, Eye right, Black Sacrificed by design for Clin Path, for Clin Path, for Clin Path, Bilateral Left Right 0,7,14-28,35-49,63-70,112,147-154, 161-181 34 9,55,76,89,92-96,101,108,139,160,181 0-3,21,115,125 56,77-84,90,98,105,119,126-133,140 181 MI MI 643232 643265 Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forepaw, Bilateral Feces, Present, Brown Sacrificed by design General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Bilateral no blood Eye Observations, Bled via Orbital for Clin Path, Bilateral bled by tail vein Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Left Eye Observations, tail vein Discharge, Nose, Black Discharge, Eye left, Black Hair Loss, Face, Left Sacrificed by design 3,9,21,101 55,96,139,160,181 0,34,76,89,92,108,115,125 0 , 7 , 14- 28, 35- 49, 56- 70, 77- 84, 90, 98,105,112,119,126-133,140-154,161-181 21 181 0,21-28,35-49 119,126-133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-181 56-70 9,21,55 101 108,115,125 0-3,34,76,89,92-96,139,160,181 147-154,161-181 70,77-84,90,98,105,112,119,126-133, 140 160 7,14 56-63 70 181 Company Sanitized. Does not contain T S C A CBI 633 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal M1 643239 MI MI MI MI MI MI MI MI 643270 643148 643284 643229 643196 643176 643218 643207 MI MI MT MI MI MI 643280 643271 643211 643163 643197 643242 Observation General observation, No Abnormality Detected Hair Loss, Shoulder, Left Wound, Superficial, Shoulder, Left Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnorma1ity Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 634 ) OBSERVATIONS AND MORTALITY DATA Days 0,21-74 14 7 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-35 42-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 ;ampany Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation MI 643251 General observation, No Abnormality Detected Removed from study MI 643155 General observation, No Abnormality Detected Removed from study MI 643147 General observation, No Abnormality Detected Removed from study MI 643276 General observation, No Abnormality Detected Removed from study MI 643237 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 643226 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 643195 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 643246 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MX 643253 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 643262 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 643172 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design Mi 643303 General observation, No Abnormality Detected Hyperreactive No Ophthalmological Abnormalities Detected Sacrificed by design MI 643304 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 635 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-112 119,125 80,122 125 0-77,84-119,125 80,122 125 DuPont-5386 jmpany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal MI 643162 MI MI 643254 643145 MI 643204 Observation General observation, No Abnormality Detected General Teeth Observations, Clipped Hyperreactive No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Eye Observations, Closed, Left Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Eye Observations, Eye Observations, Eye Observations, unable to bleed Eye Observations, Exophthalmus, Left Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Left Left Right Right Eye Observations, tail vein Discharge, Nose, Black Discharge, Eye left, Black Discharge, Eye right, Black Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-35 58-77,84-119,125 112-119,125 80,122 42-77,84-105 125 125 0-74 74 0 181 84.90.98.105.112.119.126- 133,140-154, 161-175 14-28,35-49,56-70,77-84,90,98, 105.112.119.126- 133,140-154,161-175 6-7 3,92,125 0,21,34,55,76,89,96,101,108,115,139,160,181 9 14-28,35-49,56-70,77-84,90,98, 105,112,119,126-133,140-154,161-175 160 35 7,56 77-84,90 181 0-42,49-77,84-91 91 44 80 91 Company Sanitized. Does not contain T S C A C B l ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal M III 643173 M III 643290 M III 643272 M III 643292 M III 643228 M III 643308 M III 643264 M III 643240 M III 643180 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91 91 44 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 91 44 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design Right 0-42,49-70 44,91 80 77,84-91 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI 637 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M III 643179 M III 6432Q2 M III 643310 M III 643306 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left Discharge, Nose, Black Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Discharge, Ear left, Black Discharge, Eye bilateral, Black Discharge, Nose, Black Stain Fur/Skin, Face, Black Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Ear left, Black Discharge, Eye left, Black Discharge, Eye right. Black Hair Loss, Forepaw, Left Wound, Superficial, Face Wound, Superficial, Nose Sacrificed by design Days 0-42,49-77,84-91 44,91 80 91 0,7,14-28,35,70 56,140-154,161 34,55,89,92,115,125 9,21,96,139,160,181 0-3,76,101,108 77-84,90,98,105,112,119,126-133, 140-154,161-181 42-49,56-63 181 0,7,14-28,35-49,56-70,77-84,90, 98,105,147,181 3,55,139 9,21,92-96,115,125,160,181 0,34,76,89,101,108 126 133,140 112,119,126-133,140,154,161-175 119,126 181 0,7,14,28,35-42,56,70,77-84,90,98,105, 112 119,126-133,140-154,161 3,34 9,55,96,115,139,160,181 0,21,76,89,92,101,108,125 126 133,140-147 63 140-154,161-181 21 49 181 ompany Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M III 643305 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right General Teeth Observations, Clipped Breathing Observations, Noise Discharge, Eye left, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,90, 98,105,112 160,181 9,21,55,96,101,108,115,125,139 0-3,34,76,89,92 119,126-133,140-154,161-175 147-154,161-181 126 181 M III M III M III M III 643293 643287 643188 643230 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right, Black Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 0,7,14-28,35-49,56-70,77-84,90, 98,105,112,119,133,140-154,161-168 9,21,55,96,108,139,160,181 0-3,34,76,89,92,101,115,125 126 181 181 175 181 0-14, ! 21-49 74 0-74 74 0-74 74 M III 643170 General observation, No Abnormality Detected Removed from study 0-74 74 M III M III M III 643144 643277 643214 General observation, No Abnormality Detected Hair Loss, Forepaw, Right Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 0-21 28-74 74 0-74 74 0-74 74 M III M III 643261 643166 General observation, No Abnormality Detected Removed from study General observation. No Abnormality Detected Removed from study 0-74 74 0-74 74 DuPont-5386 npany Sanitized. Does not contain T S C A C B l 639 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal M III 643153 M III 643177 M III 643198 M III 643291 M III 643184 M III 643167 M III 643223 M III 643233 M III 643183 M III 643219 M III 643263 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Observation General observation, No Abno rma1ity Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Wound, Superficial, Tail Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation,, No Abnormality Detected Removed from study General observation,, No Abnorma1ity Detected Removed from study General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study General observation,, No Abnorma1ity Detected Removed from study General observation,, No Abnormality Detected Removed from study General observation , No Abnormality Detected Removed from study 640 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-14 21-49 56-74 21-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-49,74 56-63 58-70 74 0-74 74 0-74 74 0-74 74 I DuPont-5386 Company Sanitized. Does not contain T S C A CBI 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 643250 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44.91 80 91 643243 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Left Right 0-42,49-77,84-91 44 91 80 91 MV 643311 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44.91 80 91 MV 643318 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44.91 80 91 MV 643247 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Thoracic, Ventral Mass Thoracic, Lateral, Mass #1, Ulcerated, 1.5 cm Mass Thoracic, Lateral, Mass #1, Not Ulcerated, 2.0 CM Mass Thoracic, Lateral, Mass #1, Not Ulcerated, 1.5 CM Sacrificed by design 0-42,49-56 44.91 80 91 84-90 77 58-70 91 643175 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Breathing Observations, Fast Breathing Observations, Labored Discharge, Mouth, Red Discharge, Nose, Black Muscle Tone, Decreased Pale Comments, excessive toe nail bleed Comments, 2ml blood Stain Fur/Skin, Inguen, Brown Stain Fur/Skin, Perineum, Brown Stained Cageboard, Red, alot of red from toe nail Accidentally Killed 0-42,49-56 44 77 77 66-76 63-76 73-77 73-77 76 66 77 73-77 73-77 77 i DuPont-5386 Jompany Sanitized. Does not contain T S C A CBI 641 ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 643314 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Absent No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77 44.91 84-91 80 91 MV 643275 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 MV 643257 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 91 44 80 91 MV 643224 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44.91 80 91 MV 643169 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Partially Closed Eye Observations, Enophthalmus, Left Eye Observations, Eye Observations, Eye Observations, Eye Observations, Eye Observations, by tail vein Eye Observations, Exophthalmus, Left Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Left Bilateral Left Right Right, bled Discharge, Eye left, Black Hair Loss, Face, Left Swollen Observations, Face Sacrificed by design 0,7,14-28,35-49 133,140-154,161-181 119,126 77-84,90,98,105,112,119,126-133, 140-154,161-175 56-70 55 9,21,115 0-3,34,76,89,92-96,101,12 5,13 9,160,181 108 77-84,90,96,105,112,119,126-133, 140-154,161-175 56-63 70,77-84,90,98,105 56-70,77-84 181 impany Sanitized. Does not contain T S C A CB! 642 )I i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction E v a lu a tio n s ________________________________ _______________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV MV MV 643159 643286 643181 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbitalfor Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Right General Teeth Observations, Maloccluded General Teeth Observations, Clipped Hyperreactive Discharge, Eye left, Black Discharge, Eye right, Black Sacrificed by design General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye left, Black Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Comments, compound evident on lips Sacrificed by design 0 161-181 9,21,55,96,108,139,160,181 0-3,34,76,89,92,101,115,125 175-181 7,14-28,35-49,56-70,77-84,90, 98.105.112.119.126- 133,140-154,161-168 119.126- 133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-175 126-133,140-154,161-175 126-133,140-154,161-168,181 35 181 0,7,14-28,35-49,56-70,77-84,90, 98,105,112,119,133,140-154,161-181 126 3,21,55,96,108,115,125,139,160,181 0,9,34,76,89,92,101 126 181 0,7,14-28,35-49,56-70,77,82-84, 90 0 9,21,55,76,89,92-96,101,108,115,139,160, 181 3,34,125 98,105,112,119,126-133,140-154,161-181 81 181 MV 643206 General observation. No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,42-49,56-70,77-84,90, 98,105,112,119,126-133,140-154,161-181 35 76,108,115,125,139 3,9,21,55,96,160,181 0,34,89,92,101 35 181 MV 643313 General observation, No Abnormality Detected Removed from study 0-74 74 MV 643182 General observation, No Abnormality Detected Removed from study 0-74 74 ^mpany Sanitized. Does no! contain T S C A CBI 643 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation MV 643146 General observation, No Abnormality Detected Hair Loss, Forepaw, Right Removed from study MV 643312 General observation, No Abnormality Detected Removed from study MV 643199 General observation, No Abnormality Detected Removed from study MV 643267 General observation, No Abnormality Detected Removed from study MV 643216 General observation, No Abnormality Detected Removed from study MV MV 643244 643245 General observation, No Abnormality Detected Hyperreac tive Removed from study General observation, No Abnormality Detected Removed from study MV 643301 General observation, No Abnormality Detected Hair Loss, Forelimb, Left Removed from study MV 643200 General observation, No Abnormality Detected Removed from study MV 643255 General observation, No Abnormality Detected Removed from study MV 643157 General observation, No Abnormality Detected Hyperreactive Removed from study MV 643238 General observation, No Abnormality Detected Removed from study MV 643227 General observation, No Abnormality Detected Removed from study MV 643164 General observation, No Abnormality Detected Removed from study 644 OBSERVATIONS AND MORTALITY DATA Days 0-70 74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-14,63-74 21-56 74 0-74 74 0-70 74 74 0-74 74 0-74 74 0-49 56-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal MV 643154 MV 643156 MV 643208 MV 643190 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 643194 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected. Sacrificed by design 0-42,49-77,84-91 44,91 80 91 M VII 643252 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-70 44,91 77,84-91 80 91 M VII 643260 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Wound, Superficial, Shoulder, Left Sacrificed by design 0,42,49-77,84-91 44,91 80 7-35 91 M VII 643315 Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Sacrificed by design 44,91 84-91 80 42,49-77,84-91 0-35 91 M VII 643215 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Stain Fur/Skin, Forepaw, Left, Red Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Face, Red Sacrificed by design 0-42,49-63 44,91 77,84-91 80 70 70 70 91 M VII 643193 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Comments, compound present on mouth Sacrificed by design Right 0-42,49-56 44,91 57-77,84-91 80 57 91 M VII 643298 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Swollen Observations, Nose Sacrificed by design 0-42,49-77 44,91 84-91 80 84 91 DuPont-5386 Company Sanitized. Does not contain T S C A CBI )) I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Sex Group Animal M VII 643201 M VII 643259 M VII 643174 M VII 643283 M VII 643149 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Misshapen Observations, Tail Sacrificed by design Right 0 44,91 84-91 80 7-42,49-77,84-91 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-56 91 44 57-77,84-91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Broken General Teeth Observations, Maloccluded General Teeth Observations, Clipped Discharge, Nose, Black Sacrificed by design 0,7,14-28,35-49,56 76,160 9,21,55,96,108,139,181 0-3,34,89,92,101,115,125 70 58-70,77-84,90,98,105,112,119,126-133, 140-154,161-181 58-70,77-84,90,98,105,112,119,126-133, 140-154,161-175 112,119 181 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right General Teeth Observations, Clipped Hyperreactive Discharge, Nose, Black Hair Loss, Forepaw, Bilateral Sacrificed by design 0,7,14,181 101 3,21,55,96,108,115,125,139,160,181 0,9,34,76,89,92 119,126-133,140-154,161-175 133,140-154,161-175 112,119,126 21-28,35-49,56-70,77-84,90,98, 105 181 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII M VII M VII 643178 General observation, No Abnormality Detected Eye Observations, Partially Closed, Right Eye Observations, Enophthalmus, Right Eye Observations, Eye Observations, Eye Observations, Eye Observations, bleed Eye Observations, Exophthalmus, Right Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Right Left Right unable to General Teeth Observations, Clipped Discharge, Nose, Brown Wound, Superficial, Mouth Sacrificed by design 643152 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right General Teeth Observations, Clipped Discharge, Eye right, Black Comments, compound evident on mouth Sacrificed by design 643295 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Sacrificed by design 0,7,14-21 119.126- 133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-181 28.35- 54,56-70 9,55,76,89,92-96,108,115,125,13 9,160,181 0-3,34,101 21 28.35- 54,56-70,77-84,90,98,105,112, 119.126- 133,140-154,161-181 54,56-7 0,77-84,90,98,105,112,119, 126-133,140-154,161-175 28 28,35 181 0,7,14-28,35-49,63-70,77-84,90, 98.105.181 55,76,89,92 9.21.96.101.108.115.125.139.160.181 0-3,34 112,119,126-133,140-154,161-175 56 10 181 0,7,14-28,35-49,56,181 9,21,55,96,108,139,160,181 0-3,34,76,89,92,101,115,125 57-70,77-84,90,98,105,112,119,126-133, 140-154,161-175 181 M VII 643289 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study 0-49,74 54-70 74 M VII 643171 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Nose, Red Discharge, Eye right, Red Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Periocular, Right,Brown Removed from study 0 70-74 70 70 70 14-74 7 70 74 74 Company Sanitized. Does not contain T S C A )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M VII 643158 General observation, No Abnormality Detected Removed from study M VII 643249 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Nose, Black Diarrhea, Brown Stain Fur/Skin, Forepaw, Bilateral, Red Removed from study M VII 643161 General observation. No Abnormality Detected General Teeth Observations, Clipped Removed from study M VII 643309 General observation, No Abnormality Detected General Teeth Observations, Clipped Breathing Observations, Labored Breathing Observations, Noise Discharge, Mouth, Red Discharge, Nose, Red Stain Fur/Skin, Forepaw, Bilateral, Red Stain Fur/Skin, Perineum, Yellow Accidentally Killed M VII 643248 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study M VII 643285 General observation, No Abnormality Detected Abnormal Gait, Hindlimb, Left Swollen Observations, Hindlimb, Left Removed from study M VII 643278 General observation, No Abnormality Detected Discharge, Mouth, Clear Removed from study M VII 643299 General observation, No Abnormality Detected Removed from study M VII 643274 General observation, No Abnormality Detected Hyperreactive Removed from study 649 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-63 70-74 70 70 70 70 74 0-63,74 70 74 0-49 54-70 70 69 69-70 70 70 70 70 0-63,74 70 70 74 0-56,74 63-70 63-70 74 0-28,56-74 31-49 74 0-74 74 0-14,56-74 21-49 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBJ )! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal M VII 643192 M VII 643222 M VII 643160 M VII 643191 M VII 643203 M VII 643282 M VII 643302 M VII 643317 M VII 643225 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Observation General observation, No Abnormality Detected Comments, teeth loose General Teeth Observations, Broken General Teeth Observations, Clipped Comments, teeth loose Removed from study General observation. No Abnormality Detected Removed from study General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Discharge, Mouth, Clear Removed from study General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study General observation, No Abnormality Detected General Teeth Observations, Clipped Discharge, Eye right, Red Stain Fur/Skin, Periocular, Bilateral, Black Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 650 OBSERVATIONS AND MORTALITY DATA Days 0-63 67 70-74 70 67 74 0-74 74 0-63 74 70 74 0-74 74 0-28,56-70 74 74 34-49 74 0-63 70-74 70 74 0-63 74 70 74 74 0-74 74 0-49 54-77,84-119,125 80,122 125 DuPont-5386 Company Sanitized. Does not contain T S C A CBl ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M VII 643296 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Diarrhea, Brown Stain Fur/Skin, Tail, Brown Stain Fur/Skin, Chin, Red Sacrificed by design M VII 643258 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Comments, animal did not receive whole dose Stain Fur/Skin, Perineum, Red Sacrificed by design M VII 643316 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643220 General observation. No Abnormality Detected Eye Observations, Enophthalmus, Right General Teeth Observations, Absent General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643236 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643165 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643266 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 651  OBSERVATIONS AND MORTALITY DATA Days 0-63 70-77,84-90 98-119,125 80,122 70 119,125 70 125 0-35,42-63,84-119,125 80,122 41 70-77 125 0-77,84-105 112-119,125 80,122 125 0-28 35-77,84-119,125 63 70-77,84-119,125 63-77,84-119,125 80,122 125 0-21,35-56 63-70 70 63-77,84-119,125 28-34 80,122 125 0-70 76-77,84-90 87-119,125 80,122 125 0-70 77,84-119,125 80,122 125 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M VII 643151 M VII 643234 M VII 643281 Observation General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Left Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Aggressive Behavior Hyperreact ive No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design General observation, No Abnormality Detected Removed from study, rat physically removed 2/24/01 Days 0-77,84-90 98-119,125 80,122 125 125 0 80-90 70-119,125 119,125 90-119,125 80,122 7-119,125 125 0-74 80 DuPont-5386 Company Sanitized. Does not contain T S C A CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal F II 643477 F II 643374 F II 643406 F II 643486 F II 643361 F II 643463 F II 643398 F II 643436 F II 643362 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91,93 45,92 93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91,93 45,92-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Defected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II F II 643354 643402 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Closed, Left Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path Left Eye Observations, Bled via Orbital for Clin Path Right Eye Observations, Corneal Opacity, Left Discharge, Nose, Black Hair Loss, Face, Left Sacrificed by design 0-42,49-77,84-93 45,93 80 93 0, 7 , 14- 28, 35-49 175-181 112, 119, 126- 133, 140- 154, 161-168 77- 84, 91, 98, 105, 112, 119, 126- 133, 140- 154, 161-181 56-70 9 0 -, 231, 3 4 , 5 5 , 7 6 , 89 , 9 2 - 9 6 , 1 01 , 1 0 8 , 1 15 , 1 2 5 , 139, 160,181 70, 77- 84, 91, 98, 105, 112, 119, 126- 133, 140- 154, 161-181 105 70 181 F II TT 643383 643465 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Breathing Observations, Noise Discharge, Eye bilateral. Black Discharge, Eye bilateral, Brown Discharge, Nose, Black Discharge, Eye right, Black Discharge, Eye right, Brown Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right General observation. No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Discharge, Eye bilateral, Black Discharge, Eye right. Black Hair Loss, Face, Right Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 0,7,14-28,35-49,56-70,77-84,91, 147-154 55 9,21,96,108,160,181 0-3,34,76,89,92,101,115,125,139 140 98,105,112,119,126-133 161 98,105,112 140 168-181 181 0,7,14-28,35-49,56-70,77-84,91, 98,119,147-154,161-181 0 9,21,96,139,160,181 3,34,55,76,89,92,101,108,115,125 133,140 105,126 112 181 flpany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 643484 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbitalfor Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbitalfor Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Left Breathing Observations, Noise Discharge, Eye bilateral. Black Discharge, Eye right, Black Sacrificed by design 0,7,14-21 35-49 3,9,21,34,55,76,160 96,139,181 0,89,92,101,108,115,125 35-49,56-70,77-84,91,98,105,112, 119,126-133,140-154,161-181 28 140-154,161-181 77 35-42,56 181 F II F II 643384 643352 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design General observation, No Abnormality Detected Removed from study 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,147-154,161-181 119,126-133,140 9,21,96,108,115,125,139,181 0-3,34,55,76,89,92,101,160 181 0-74 74 F II 643343 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643459 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643394 General observation, No Abnormality Detected Removed from study 0-74 74 F 11 643480 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643319 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643350 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643363 General observation, No Abnormality Detected Removed from study 0-74 74 F II 643397 General observation, No Abnormality Detected Removed from study 0-74 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F II 643421 General observation, No Abnormality Detected Removed from study F II F II F II F II F II F II F II F II F II F II p II F II 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Sacrificed by design General observation, No Abnormality Detected No Ophthalmological .Abnormalities Detected Sacrificed by design F II 643448 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 656 ) OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-21 80,122 28-77,84-112 119,125 125 0-77,84-119,125 80,122 125 0-56,112-119,125 80,122 63-77,84-105 125 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F II 643426 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643415 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643453 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643330 General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643336 General observation, No Abnormality Detected Discharge, Vulva, Red No Ophthalmological Abnormalities Detected Mass Perineum, Mass #1, Ulcerated, 1.0 cm Sacrificed in extremis F II 643387 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643377 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 657 OBSERVATIONS AND MORTALITY DATA Days 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-98 105 80 105 105 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 ) DuPont-5386 company Sanitized. Does no! contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal F IV 643390 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-77,84-91,93 45,92-93 80 93 F IV 643396 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Side, Left Sacrificed by design Right 0-42,49-77 45,92-93 80 84-91,93 93 F IV 643380 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV 643433 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV F IV 643389 643410 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped Discharge, Eye right, Black No Ophthalmological Abnormalities Detected Sacrificed by design Right General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-56 45,93 58-77,84-93 63-70 80 93 0-42,49-77,84-93 45,93 80 93 F IV F IV 643321 643324 General observation, No Abnormality Detected Abnormal vocalization Convulsions, Clonic, went stiff Breathing Observations, Fast Prostrate Diarrhea, Brown Sacrificed in extremis General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Hyperactive No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-28 29 29 29 29 29 29 0-42,49 45,93 56-77,84-93 80 93 DuPont-5386 Company Sanitized. Does not contain T S C A CBI 658 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Sex Group Animal F IV 643458 F IV 643364 F IV 643483 F IV 643411 F IV 643379 F IV 643391 F IV 643437 F IV 643399 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45.93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45.93 80 93 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154,161-181 0-3 9,21,96,108,139,160,181 34,55,76,89,92,101,115,125 181 Eye Observations, Bled via Orbital for Clin Path, Right Comments, ak during bleed Accidentally killed General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Eye Observations, Bled via Orbital for Eye Observations, Bled via Orbital for Discharge, Eye right, Black Discharge, Eye right, Brown Sacrificed by design Clin Path, Bilateral Clin Path, Left Clin Path, Right 0,7,14-28,35-49,56-70,77-84,91, 98,105,126,147-154,161-181 101,108,115,125 3.9.21.96.139.160.181 0,34,55,76,89,92 112,119 133,140 181 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Eye Observations, Bled via Orbital for Hair Loss, Nose Wound, Superficial, Nose Sacrificed by design Clin Path, Left Clin Path, Right 0,7,49,56-70,77-84,91,98,105,112,119, 126-133,140-154,161-181 3.9.21.96.108.139.160.181 0,34,55,76,89,92,101,115,125 21-28,35-42 14 181 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154,161-181 3.9.21.96.108.139.160.181 0,34,55,76,89,92,101,115,125 181 General observation, No Abnormality Detected Removed from study 0-74 74 Company Sanitized. Does not contain T S C A C B l 659 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F IV 643334 General observation, No Abnormality Detected Removed from study F IV 643464 General observation, No Abnormality Detected Removed from study F IV 643369 General observation, NO Abnormality Detected Removed from study F IV 643490 General observation, NO Abnormality Detected Removed from study F IV 643342 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Removed from study F IV 643438 General observation, No Abnormality Detected Removed from study F IV 643445 General observation, No Abnormality Detected Comments, compound evident on mouth Removed from study F IV 643418 General observation, No Abnormality Detected Removed from study F IV 643325 General observation, No Abnormality Detected Removed from study F IV 643479 General observation, No Abnormality Detected Removed from study F IV 643403 General observation, No Abnormality Detected Removed from study F IV 643376 General observation, No Abnormality Detected Removed from study F IV 643422 General observation, No Abnormality Detected Removed from study F IV 643452 General observation, NO Abnormality Detected Removed from study F IV 643475 General observation, No Abnormality Detected Removed from study 660 ) OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-14 21-56 63-74 74 0-74 74 0-70,74 73 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal F IV 643372 F IV 643400 F IV 643395 F IV 643457 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation ays General observation, No Abnormality Detected Removed from study 0-74 74 General observation, NO Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 0-74 74 0-74 74 I DuPont-5386 .`ompany Sanitized. Does not contain TSCA CBI 661 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal F VI 643322 F VI 643489 F VI 643409 F VI 643366 F VI 643367 F VI 643461 F VI 643462 F VI 643392 F VI 643472 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91,93 45,92-93 80 93 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, Retina, Retinal Degeneration Diffuse, Left Sacrificed by design Bilateral Right 0-42,49-77,84-93 93 45 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 643323 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Comments, protective gavage ball fell off predose Sacrificed by design 0-28,35-42,49-77,84-93 45,93 80 34 93 F VI 643412 General observation, No Abnormality Detected Eye Observations, Bled via Eye Observations, Bled via Eye Observations, Bled via Sacrificed by design Orbital for Orbital for Orbital for Clin Clin Clin Path, Bilateral Path, Left Path, Right 0,7,14-28,35-49,56-70,77-84,91, 98.105.112.119.126-133,140-154,161-181 181 3,9,21,96,108,139,160 0,34,55,76,89,92,101,115,125 181 F Vi 643382 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Discharge, Eye left, Black Wound, Superficial, Mouth Sacrificed by design 0,7,14-21 112.119.126- 133,140-154,161-181 49,56-70,77-84., 91,98,105,112,119, 126-133,140-154,161-181 28,35-42 30., 93.42, 15.51, 1756 , 8 9 , 9 2 - 9 6 , 1 0 1 , 1 0 8 , 1 2 5 , 1 3 9 , 1 6 0 , 181 35-49,56-70,77-84,91,98,105,112, 119.126- 133,140-154,161-181 126-133,140-154,161-181 28,35 63 181 F VI 643381 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98.105.112.119.126- 133,140-154,161-181 3.9.21.96.108.139.160.181 0,34,55,76,89,92,101,115,125 181 F VI 643360 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Discharge, Nose, Black Discharge, Eye left, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84 98,105,112,119,126 91 89.92.108.115 3.9.21.96.139.160.181 0,34,55,76,101,125 98.105.112.119.126- 133,140-154,161-181 161-181 119 98,105,112 181 Company Sanitized. Does not contain T S C A CB! 663 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 643373 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Bilateral Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28 56-70 77-84,91,98,105,112,119,126-133, 140-154,161-181 35-49 0,55,76,89,92,108,115 3,9,21,96,139 34,101,125,160,181 56-70,77-84,91,98,105,112,119,126 140-154,161-181 35-49 35 181 F VI 643320 General observation, No Abnormality Detected Removed from study 0-74 74 F VI F VI 643488 643428 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 0-74 74 0-74 74 F VI 643439 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643353 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643385 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643339 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643473 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643337 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643416 General observation, No Abnormality Detected Removed from study 0-74 74 F VI 643407 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Comments, compound evident on lips Removed from study 0-28,36-42 49-74 35 74 Company Sanitized. Does not contain T S C A CBI 664 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal F VI 643357 F VI 643331 F VI 643427 F VI 643470 F VI 643434 F VI 643349 F VI F VI F VI 643454 643333 643460 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-21,74 28-70 74 General observat ion, No Abnormality Detected Removed from study 0-74 74 General observation, NO Abnormality Detected Removed from study 0-74 74 General observation, NO Abnormality Detected Removed from study 0-74 74 DuPont-5386 Company Sanitized. Does not contain T S C CD! I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal F VIII 643341 F Vili 643370 F VTII 643446 F VIII 643435 F VIII 643466 F VIII 643332 F VIII 643404 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right Days 0-42,49-70 45,92-93 76-77,84-91,93 80 93 0-42,49-63 45,93 65-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-56 45,93 63-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped Hyperactive Hyperreactive No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-63 45,93 84-93 70-77,84-93 70-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-77 45,93 84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-56 45,93 63-77,84-93 80 93 0-42,49-77 45,93 84-93 80 93 I DuPont-5386 Company Sanitized. Does no! contain T S C A C B l H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 643408 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-63 45,93 70-77,84-93 80 93 F VIII 643359 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F Vill 643340 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hair boss. Forepaw, Bilateral Found dead in cage. 0-14 45 21-42,49-69 69 F VIII 643487 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right General Teeth Observations, Clipped Sacrificed by design 0,7,14-28,35-49,56-70 77-84 76,89,92 3,9,21,96,108,139,160,181 0,34,55,101,115,125 77-84,91,98,105,112,119,126-133, 140-154,161-181 80,119,126-133,140-154,161-181 181 F Vili 643356 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Bilateral Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right 0,7,14-28 112,119,126-133,140-154,161-175 181 35-49 161-175 21,34 3,9 0,55,76,89,92-96,101,108,115,125,139,160, Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Breathing Observations, Noise Discharge, Eye left, Black Discharge, Eye right, Black Hair Loss, Face, Right Comments, compound evident on mouth Sacrificed by design 35-49,56-84,91,98,105,112 105,112,119,126-133,140-154,161-181 140-154,161-175 35,98,105,112,119 161-175 49 76 181 Company Sanitized. Does not contain T S C A CB )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 643329 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Hair Loss, Neck, Dorsal Hair Loss, Nose Sacrificed by design 0,7,42-49,56-70,77-84,91,98 101 3,9,21,96,108,139,160,181 0,34,55,76,89,92,115,125 105.112.119.126- 133,140-154,161-181 14-28,35 14.119.126- 133 181 F VIII 643388 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Sacrificed by design F VIII 643450 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Discharge, Eye left, Black Comments, growth on left eye Sacrificed by design 0,7,14-28,35-49 3,9,21,96,108,139,160,181 0,34,55,76,89,92,101,115,125 54,56-70,77-84,91,98,105,112,119, 126-133,140-154,161-181 181 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154 161-181 108,115 3,9,21,96,139,160 0,34,55,76,89,92,101,125,181 168-181 161-181 161 181 181 F VIII 643467 General observation, No Abnormality Detected General Teeth Observations, Clipped Hair Loss, Hindlimb, Left Hair Loss, Side, Right Removed from study 0-63 70 74 74 74 F VIII 643443 General observation, No Abnormality Detected Removed from study 0-74 74 F VIII 643417 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study 0-63,74 70 74 F VIII 643413 General observation, No Abnormality Detected Removed from study 0-74 74 F VIII 643338 General observation, No Abnormality Detected Removed from study 0-74 74 668 Company Sanitized. Does not contain T S C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F VITI 643335 General observation, No Abnormality Detected Removed from study F Vili 643468 General observation, No Abnormality Detected General Teeth Observations, Clipped Discharge, Nose, Red Diarrhea, Black Stain Fur/Skin, Face, Brown Removed from study F VIII 643440 General observation. No Abnormality Detected General Teeth Observations, Clipped Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Face, Brown Removed from study F VIII 643430 General observation, No Abnormality Detected Comments, teeth loose General Teeth Observations, Absent General Teeth Observations, Broken Removed from study F VIII 643431 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study F VIII 643368 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Bilateral Discharge, Mouth, Tan Dehydrated Stain Fur/Skin, Perineum, Yellow Wet Fur, Perineum Accidentally Killed F VIII 643326 General observation. No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Discharge, Eye bilateral, Black Discharge, Mouth, Clear Removed from study F VIII 643365 General observation, No Abnormality Detected Removed from study F VIII 643375 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study 669  OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-63,74 70 70 70 70 74 0-56,74 63-70 70 63-70 74 0-70 71 71-74 71-74 74 0-63 70-74 74 0-42 49-53 47-53 47-53 47-53 47-53 53 0-56,74 63-70 63-70 63 63 74 0-74 74 0-70 74 74 DuPont-5386 Company Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F VIII 643328 General observation, NO Abnormality Detected Removed from study F VIII 643348 General observation, No Abnormality Detected Removed from study F VIII 643346 General observation, No Abnormality Detected Removed from study F VIII 643449 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study F VIII 643429 General observation, No Abnormality Detected General Teeth Observations, Clipped Hair Loss, Forelimb, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Hindiimb, Right Hair Loss, Side, Bilateral Hair Loss, Side, Right Removed from study F VIII 643424 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study F VIII 643347 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643456 General observation, No Abnormality Detected General Teeth Observations, Maloccluded General Teeth Observations, Clipped Discharge, Eye right, Red No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643423 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Mass Abdomen, Mass #2, Not Ulcerated, 1.0 cm Mass Side, Left, Mass #1, Not Ulcerated, 1.5 cm Mass Side, Left, Mass #1, Not Ulcerated, 1 cm. Sacrificed by design 670 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-56,74 63- 70 74 0-28 70 42-74 42-74 35 56-74 49 74 0-70 74 74 0-77,84-112 119.125 80,122 125 0-49 119.125 54-77,84-119,125 119.125 80,122 125 0-14 21-77,84-119,125 84-119,125 80,122 119.125 112-119,125 64- 77,84-105 125 DuPont-5386 Company Sanitized. Does not contain T S C A CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal F VIII 643345 Observation General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-49 54-77,84-119,125 80,122 125 F VIII F VIII 643351 643358 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 0-56 63-65 65-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 F VIII F VIII F VIII 643444 643474 643441 General observation. No Abnormality Detected General Teeth Observations, Clipped General Teeth Observations, Clipped, teeth caught in cage No Ophthalmological Abnormalities Detected Stain Fur/Skin, Shoulder, Right, Brown Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-14 105-119,125 73 80,122 21-77,84-112 125 0-77,84-119,125 80,122 125 0-56 63-77,84-119,125 80,122 125 F VIII 643481 General observation. No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-77,84-98 105-119,125 80,122 125 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX F OPHTHALMOLOGY EXAMINATION REPORTS Jampany Sanitized. Does not contain TSCA CBI 672 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLOGICAL EXAMINATION REPORT (TEST DAY 80) DuPont-5386 NANCY M. BROMBERG, V.M.D., M.S. EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE BETHESDA, MD 20816 STUDY INFORMATION: Study No Species:] Study Director: Greg Ladies OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: March 2,2001 METHODS: Indirect Ophthalmoscopy following 1% Tropicamide mydriasis Sex Group# Cage # Animal # Observation Female VI 606 643461 Diffuse retinal degeneration OS COMMENTS/D1SCUSSION One female was identified with retinal degeneration which may be due to trauma to the orbit aud/or globe during orbital sinus bleeding. AH other animals examined bad no visible ophthalmoscopic lesions. No compound related abnormalities were identified. ontpany Sanitized. Does not contain T S C A CB\ 673 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLOGICAL EXAMINATION REPORT (TEST DAY 122) DuPont-5386 NANCY M. BROMBERG, V.M.D., M.S., D.A.C.V.O. EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE BETHESDA, MD 20816 STUDY INFORMATION: stud? N i W J SpeciesrRat Study Director: Greg Ladies OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: April 13,2001 METHODS: Indirect Ophthalmoscopy following 1% Tropicamide mydriasis COMMENTS/DISCUSSION All animals examined had no visible ophthalmoscopic lesions. Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX G INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group I 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Forelimb Grip Strength (kel Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.52 0.51 0.59 0.54 0.51 0.83 0.55 0.63 0.60 0.57 0.35 0.51 0.56 0.65 0.60 0.60 0.36 0.29 0.48 0.38 0.39 0.48 0.48 0.45 0.52 0.48 0.58 0.53 0.52 0.60 0.59 0.57 0.49 0.56 0.51 0.52 0.40 0.44 0.38 0.41 Trial 1 0.45 0.31 0.40 0.36 0.58 0.32 0.34 0.51 0.37 0.23 Hindlimb Grip Strength (kg') Trial 2 Trial 3 Mean of Three Trials 0.37 0.43 0.42 0.39 0.45 0.38 0.38 0.42 0.40 0.39 0.28 0.34 0.34 0.51 0.48 0.53 0.30 0.38 0.39 0.52 0.42 0.47 0.59 0.52 0.39 0.33 0.36 0.43 0.30 0.32 Company Sanitized. Does not contain TS C A CBF H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group III 25 mg/kg/day Animal Number 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Forelimb Grip Strength ikel Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.60 0.53 0.43 0.52000 0.42 0.33 0.64 0.46333 0.45 0.48 0.56 0.49667 0.83 0.77 0.72 0.77333 0.52 0.46 0.67 0.55000 0.59 0.66 0.41 0.55333 0.38 0.36 0.55 0.43000 0.31 0.60 0.45 0.45333 0.50 0.63 0.63 0.58667 0.46 0.38 0.39 0.41000 Trial 1 0.48 0.43 0.37 0.27 0.27 0.32 0.37 0.40 0.31 0.59 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.42 0.42 0.44000 0.40 0.50 0.44333 0.47 0.56 0.46667 0.26 0.39 0.30667 0.26 0.24 0.25667 0.39 0.37 0.36000 0.42 0.39 0.39333 0.39 0.45 0.41333 0.30 0.31 0.30667 0.38 0.33 0.43333 company Sanitized. Does no! contain T S C A >) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group V lOOmg/kg/day Animal Number 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 Forelimb Grip Strength (kgt Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.50 0.65 0.41 0.52 0.57 0.42 0.44 0.48 0.47 0.37 0.37 0.40 0.71 0.50 0.80 0.67 0.64 0.51 0.46 0.54 0.56 0.48 0.48 0.51 0.59 0.70 0.54 0.61 0.74 0.47 0.55 0.59 0.64 0.60 0.56 0.60 0.53 0.41 0.38 0.44 Trial 1 0.43 0.23 0.32 0.26 0.32 0.38 0.42 0.30 0.37 0.35 Hindlimb Grip Strength (kg') Trial 2 Trial 3 Mean of Three Trials 0.30 0.35 0.36 0.47 0.28 0.33 0.39 0.30 0.34 0.29 0.39 0.31 0.26 0.39 0.32 0.32 0.43 0.38 0.32 0.40 0.38 0.37 0.35 0.34 0.43 0.46 0.42 0.45 0.32 0.37 Company Sanitized, Does not contain TSCACBI 678 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations I DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group VII 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.66 0.55 0.76 0.66 0.48 0.54 0.46 0.50 0.70 0.67 0.53 0.63 0.56 0.46 0.56 0.53 0.60 0.47 0.54 0.54 0.54 0.48 0.51 0.51 0.53 0.58 0.46 0.52 0.33 0.38 0.44 0.38 0.66 0.76 0.61 0.68 0.56 0.46 0.46 0.49 Trial 1 0.49 0.33 0.50 0.29 0.33 0.31 0.49 0.36 0.59 0.26 Hindlimb Grip Strength Ike) Trial 2 Trial 3 Mean of Three Trials 0.31 0.46 0.42 0.34 0.30 0.32 0.40 0.27 0.39 0.43 0.66 0.46 0.43 0.34 0.37 0.38 0.60 0.43 0.30 0.43 0.41 0.44 0.44 0.41 0.41 0.45 0.48 0.27 0.38 0.30 Company Sanitized. Does not contain TS C A C B I 679 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group II 0 mg/kg/day Animal Number 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.28 0.71 0.57 0.52 0.60 0.46 0.45 0.50 0.47 0.77 0.67 0.64 0.51 0.62 0.88 0.67 0.51 0.76 0.55 0.61 0.54 0.68 0.55 0.59 0.47 0.47 0.61 0.52 0.37 0.47 0.54 0.46 0.59 0.80 0.61 0.67 0.62 0.76 0.63 0.67 Trial 1 0.42 0.34 0.45 0.38 0.27 0.31 0.37 0.38 0.41 0.34 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.33 0.32 0.36 0.43 0.53 0.43 0.42 0.37 0.41 0.41 0.37 0.39 0.32 0.23 0.27 0.48 0.30 0.36 0.40 0.38 0.38 0.40 0.35 0.38 0.41 0.31 0.38 0.34 0.41 0.36 -ompBny Sanitized. Does nor contain TSCA CBI 680 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND H1NDLIMB GRIP STRENGTH Baseline Female Rats/Group IV 25 mg/kg/day Animal Number 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 Forelimb Grip Strength fkel Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.74 0.60 0.51 0.62 0.46 0.63 0.56 0.55 0.37 0.40 0.53 0.43 0.43 0.56 0.56 0.52 0.43 0.31 0.43 0.39 0.74 0.76 0.73 0.74 0.47 0.66 0.72 0.62 0.33 0.30 0.50 0.38 0.42 0.65 0.47 0.51 0.62 0.74 0.56 0.64 Trial 1 0.35 0.33 0.44 0.44 0.35 0.57 0.34 0.33 0.44 0.39 Hindlimb Grin Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.38 0.26 0.33 0.40 0.38 0.37 0.43 0.50 0.46 0.61 0.43 0.49 0.39 0.30 0.35 0.37 0.37 0.44 0.45 0.36 0.38 0.32 0.27 0.31 0.35 0.40 0.40 0.29 0.35 0.34 Company Sanitized. Does not contain T S C A CBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group VI 100mg/kg/day Animal Number 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Trial 1 0.59 0.31 0.80 0.30 0.48 0.51 0.61 0.36 0.50 0.56 Forelimb Grip Strength (kg) Trial 2 Mean of Trial 3 Three Trials 0.65 0.79 0.68 0.43 0.52 0.42 0.70 0.68 0.73 0.38 0.28 0.32 0.37 0.62 0.49 0.61 0.77 0.63 0.44 0.40 0.48 0.63 0.71 0.57 0.42 0.51 0.48 0.55 0.60 0.57 Trial 1 0.43 0.29 0.49 0.34 0.41 0.36 0.35 0.32 0.33 0.49 Hindlimb Grip Strength (kel Trial 2 Trial 3 Mean of Three Trials 0.41 0.30 0.38 0.32 0.30 0.36 0.42 0.30 0.42 0.27 0.35 0.32 0.32 0.27 0.30 0.31 0.33 0.32 0.36 0.27 0.33 0.30 0.41 0.34 0.37 0.36 0.35 0.50 0.37 0.45 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group VIII 250 mg/kg/day Animal Number 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 Forelimb Grip Strength Ike) Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.39 0.56 0.60 0.52 0.76 0.86 0.77 0.80 0.87 0.77 0.76 0.80 0.56 0.41 0.56 0.51 0.33 0.48 0.37 0.39 0.66 0.42 0.43 0.50 0.57 0.67 0.53 0.59 0.59 0.77 0.88 0.75 0.45 0.52 0.46 0.48 0.56 0.86 0.42 0.61 Trial 1 0.28 0.45 0.26 0.42 0.33 0.30 0.44 0.29 0.34 0.30 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.40 0.35 0.34 0.51 0.27 0.41 0.36 0.39 0.34 0.34 0.31 0.36 0.36 0.41 0.37 0.37 0.37 0.35 0.32 0.41 0.39 0.25 0.31 0.28 0.41 0.37 0.37 0.35 0.38 0.34 Company Sanitized. Does not contain TSCA C Bl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group I 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Forelimb Grip Strength (kg) Trial 1 Trial 2 Mean of Trial 3 Three Trials 1.44 0.99 0.99 1.14 1.39 1.73 1.63 1.58 1.60 1.18 1.51 1.43 2.29 1.33 1.64 1.75 0.87 1.05 0.94 0.95 0.80 0.96 0.69 0.82 1.48 1.46 2.10 1.68 1.43 2.32 1.20 1.65 1.65 1.69 1.59 1.64 0.84 1.54 1.17 1.18 Trial 1 0.89 1.01 0.95 0.90 0.61 0.69 0.83 1.04 1.04 0.63 Hindlimb Grip Strength (kgj Trial 2 Trial 3 Mean of Three Trials 0.71 0.86 0.82 0.65 0.78 0.80 0.98 0.81 0.91 1.01 0.90 0.94 0.85 0.83 0.76 0.59 0.51 1.14 0.87 0.60 0.95 1.20 0.91 1.05 0.96 0.80 0.93 0.61 0.62 0.62 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group III 25 mg/kg/day Animal Number 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Forelimb Grip Strength Iks') Trial 1 Trial 2 Mean of Trial 3 Three Trials 1.98 1.44 1.78 1.73 0.64 1.01 1.09 0.91 1.49 1.64 1.28 1.47 1.76 1.92 1.14 1.61 1.60 1.35 1.03 1.33 0.74 1.48 0.97 1.06 1.50 1.05 1.01 1.19 1.35 0.92 1.24 1.17 1.15 1.12 1.40 1.22 1.54 2.09 1.72 1.78 Trial 1 0.68 1.00 0.71 0.94 0.70 0.90 0.80 0.88 0.74 0.99 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.78 0.68 0.71 0.95 0.79 0.91 0.71 0.86 0.76 0.67 0.86 0.82 0.75 0.82 0.76 0.75 0.77 0.81 0.61 0.70 0.70 0.69 0.97 0.85 0.97 0.93 0.88 0.69 0.82 0.83 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group V 100mg/kg/day Forelimb Grip Strength (kg) Animal Number Trial 1 Trial 2 Mean of Trial 3 Three Trials 643175 a 643224 1.24 0.70 0.57 0.84 643243 0.76 1.03 1.25 1.01 643247 1.43 1.48 1.18 1.36 643250 1.64 1.54 1.98 1.72 643257 1.33 1.49 1.03 1.28 643275 1.99 0.92 1.05 1.32 643311 1.64 1.95 0.82 1.47 643314 1.99 1.73 1.81 1.84 643318 1.77 1.43 1.39 1.53 Trial 1 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.67 0.80 0.80 0.75 0.76 0.97 0.87 1.07 0.63 1.17 0.77 0.76 0.67 0.51 0.77 0.81 0.74 0.74 0.66 0.61 0.87 1.29 0.63 0.95 0.65 0.76 0.89 0.71 0.72 0.87 1.08 0.81 0.83 0.61 0.78 0.79 a Sacrificed in e x tr e m is prior to evaluation 686 Company Sanitized. Does not contain T S C A CBI H-24516: Subchroiiic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group VII 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 1.32 1.31 1.33 1.32 0.75 1.62 1.59 1.32 1.15 1.01 0.63 0.93 1.73 1.63 1.86 1.74 1.42 1.34 1.25 1.34 1.54 1.22 1.03 1.26 0.91 1.65 1.21 1.26 0.98 1.00 1.04 1.01 1.49 1.33 1.85 1.56 1.58 1.22 1.21 1.34 Trial 1 0.56 0.56 0.84 0.70 0.61 0.61 0.69 0.71 0.97 0.85 Hindlimb Grip Strength (ks) Trial 2 Trial 3 Mean of Three Trials 0.74 0.81 0.70 0.61 0.50 0.56 0.70 0.76 0.77 0.70 0.76 0.72 0.78 0.78 0.72 0.74 0.65 0.67 0.92 1.10 0.90 0.53 0.61 0.62 0.77 0.73 0.82 0.99 0.74 0.86 ompany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group II 0 mg/kg/day Animal Number 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.93 1.00 0.94 0.96 1.12 1.37 1.27 1.25 1.16 1.63 1.45 1.41 1.17 0.69 0.96 0.94 1.05 1.31 1.19 1.18 1.13 0.97 0.64 0.91 1.42 1.23 1.20 1.28 1.10 0.90 1.05 1.02 1.16 1.41 0.92 1.16 1.84 1.48 1.80 1.71 Trial 1 0.66 0.55 0.58 0.88 0.58 0.77 0.62 0.82 0.80 0.69 Hindlimb Grin Strength Ike! Trial 2 Trial 3 Mean of Three Trials 0.91 0.85 0.81 0.66 0.50 0.57 0.91 0.86 0.78 0.74 0.80 0.81 0.53 0.74 0.62 0.65 0.69 0.70 0.62 0.63 0.62 0.92 0.80 0.85 0.83 0.74 0.79 0.79 0.85 0.78 688 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group IV 25 mg/kg/day Animal Number 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 a Forelimb Grip Strength fkg) Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.77 0.95 1.07 0.71 0.57 1.39 1.45 1.44 0.90 1.27 1.13 1.36 1.64 1.68 1.21 1.25 1.17 1.05 1.58 1.48 1.12 1.12 1.10 1.15 1.13 1.61 1.53 0.93 0.89 1.26 1.25 1.51 1.16 1.39 1.12 1.42 Trial 1 Hindlimb Grip Strength (kel Trial 2 Trial 3 Mean of Three Trials 0.59 0.45 0.71 0.74 0.62 0.70 0.73 0.82 0.73 0.79 0.85 1.10 0.71 0.90 0.50 0.61 0.72 0.69 0.53 0.71 0.76 0.67 0.81 0.81 0.81 0.56 0.76 0.52 0.72 0.69 0.74 0.78 0.92 0.81 0.56 0.72 Sacrificed in e x tr e m is prior to evaluation. Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND H1NDLIMB GRIP STRENGTH Week 13 Female Rats/Group VI 100 mg/kg/day Animal Number 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.74 0.52 0.53 0.60 1.12 0.93 0.64 0.90 1.00 1.62 1.22 1.28 1.19 0.95 0.74 0.96 0.87 1.06 0.75 0.89 1.05 1.31 1.56 1.31 1.02 1.23 1.38 1.21 0.72 1.11 1.50 1.11 1.02 1.36 0.90 1.09 1.05 1.18 0.80 1.01 Trial l 0.42 0.56 0.75 0.69 0.45 0.50 0.62 0.75 0.55 0.70 Hindlimb Grip Strength Iksl Trial 2 Trial 3 Mean of Three Trials 0.57 0.46 0.48 0.59 0.62 0.59 0.77 0.81 0.78 0.69 0.56 0.65 0.69 0.59 0.58 0.51 0.71 0.57 0.80 0.67 0.70 0.81 0.82 0.79 0.81 0.50 0.62 0.70 0.71 0.70 Company Sanitized. Does not contain T S C A CB1 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group VIII 250 mg/kg/day Animal Number 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 Forelimb Grip Strength (kg') Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.77 0.65 0.56 0.66 0.84 0.91 0.66 0.80 0.66 1.22 0.77 0.88 0.88 0.89 0.65 0.81 1.08 1.00 1.27 1.12 0.90 1.53 0.89 1.11 1.02 1.58 1.34 1.31 0.77 0.94 0.99 0.90 1.21 1.33 1.02 1.19 1.37 1.46 1.01 1.28 Trial 1 0.75 0.64 0.69 0.67 0.58 0.66 0.84 0.34 0.54 0.98 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.66 0.59 0.67 0.54 0.71 0.63 0.51 0.57 0.59 0.45 0.53 0.55 0.67 0.64 0.63 0.71 0.71 0.69 0.88 0.92 0.88 0.35 0.36 0.35 0.72 0.67 0.64 0.75 0.63 0.79 Company anitlzed. Does not contain T S C A C B t H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Male Rats/Group I 0 mg/kg/day Animal Number 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 Forelimb Grip Strength (kg) Trial 1 Trial 2 Mean of Trial 3 Three Trials 1.09 0.78 1.30 1.06 1.26 1.37 1.66 1.43 1.42 1.16 1.67 1.42 1.31 0.82 1.51 1.21 0.69 0.73 0.79 0.74 0.99 0.76 0.81 0.85 1.10 1.22 1.34 1.22 1.83 1.86 1.21 1.63 1.16 1.62 2.08 1.62 1.89 1.04 1.56 1.50 Trial 1 0.74 0.65 0.61 0.64 0.64 0.66 1.47 0.72 0.70 0.67 Hindlimb Grip Strength (kg) Trial 2 Trial 3 Mean of Three Trials 0.65 0.62 0.67 0.92 0.78 0.78 0.76 0.76 0.71 0.58 0.61 0.61 0.61 0.65 0.63 0.77 0.62 0.68 0.76 1.05 1.09 1.01 0.81 0.85 0.70 0.58 0.66 0.71 0.76 0.71 Company Sanitized. Does not contain T S C A CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Male Rats/Group VII 250 mg/kg/day Animal Number 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Trial l 1.34 2.05 0.75 0.91 1.58 0.81 0.99 1.21 1.14 0.86 Forelimb Grin Strength (ksA Trial 2 Mean of Trial 3 Three Trials 0.80 1.30 1.15 1.85 1.45 1.78 0.62 0.73 0.70 0.94 1.22 1.02 0.60 0.55 0.91 0.93 0.75 0.83 1.01 0.86 0.95 0.89 0.77 0.96 1.27 1.55 1.32 0.70 0.55 0.70 Trial 1 0.71 0.66 0.90 0.89 0.65 0.85 0.63 0.84 0.97 0.77 Hindlimb Grin Strength (kel Trial 2 Trial 3 Mean of Three Trials 0.52 0.59 0.61 0.75 0.61 0.67 0.82 0.86 0.86 0.80 0.76 0.82 0.64 0.63 0.64 0.87 0.74 0.82 0.63 0.71 0.66 0.87 0.59 0.77 0.80 0.80 0.86 0.71 0.86 0.78 containCompany Sanitized. Does not TSCACBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Female Rats/Group II 0 mg/kg/day Forelimb Grip Strength (kg') Animal Number Trial 1 Trial 2 Mean of Trial 3 Three Trials 643330 0.65 0.64 0.55 0.61 643336 a 643377 0.93 0.86 0.98 0.92 643387 1.27 1.43 1.19 1.30 643405 0.98 0.94 1.01 0.98 643415 1.11 1.63 1.61 1.45 643425 1.15 1.51 1.34 1.33 643426 0.93 1.21 1.16 1.10 643448 0.83 0.75 0.73 0.77 643453 1.15 0.97 1.35 1.16 Trial 1 0.46 Hindlimb Grip Strength (kal Trial 2 Trial 3 Mean of Three Trials 0.58 0.54 0.53 0.76 0.67 0.80 0.72 0.55 0.59 0.73 0.61 0.73 0.65 0.82 0.90 0.59 0.73 0.93 0.59 0.78 0.76 0.63 0.67 0.70 0.79 0.58 0.69 0.74 0.76 0.59 0.67 0.69 0.84 0.63 0.74 Sacrificed in e x tr e m is prior to evaluation. Company Sanitized. Does not contain T S C A 694 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Female Rats/Group VIII 250 mg/kg/day Animal Number 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 Forelimb Grip Strength (kel Trial 1 Trial 2 Mean of Trial 3 Three Trials 0.86 0.72 0.89 0.82 0.65 0.71 0.94 0.77 1.56 1.38 0.93 1.29 0.93 1.30 1.16 1.13 0.73 1.30 0.64 0.89 1.49 1.83 1.68 1.67 1.83 1.46 1.64 1.64 0.86 0.71 1.08 0.88 0.66 0.76 1.12 0.85 1.35 1.73 1.11 1.40 Trial 1 0.68 0.64 0.57 0.53 0.68 0.66 0.79 0.61 0.48 0.70 Hindlimb Grip Strength (kg') Trial 2 Trial 3 Mean of Three Trials 0.72 0.72 0.71 0.50 0.57 0.57 0.62 0.54 0.58 0.66 0.68 0.62 0.79 0.89 0.79 0.75 0.71 0.71 0.78 0.81 0.79 0.55 0.53 0.56 0.56 0.46 0.50 0.75 0.87 0.77 Company Sani.tbed0oes nf contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Company Sanitized. Does not contain T S C A CBi 696 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY SCORING SYSTEM APPROACH & TOUCH: AUDITORY STIMULUS: TAIL PINCH: DEFECATION: URINATION: PUPILLARY RESPONSE: MANIPULATIONS IN OPEN FIELD ARENA (FREE ROAMING SPACE-) -1 = no reaction 0 - normal 1 = increased reaction (jumps away or attacks) -1 = no reaction 0 - normal reaction (rat flinches or flicks ear) 1 -- exaggerated reaction (rat jumps, flips) -1 = no response 0 normal (turns toward site) 1 = exaggerated response (vocalizations, rapid turning) IN MOTOR ACTIVITY MONITOR 0 = absent 1 = present D -- diarrhea 0 = absent I present 0 present 1 = absent Company Sanitized. Does not contain T S C A CD 697 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAJL BATTERY ASSESSMENT Male Rats/Group I: 0 mg/kg/day MANIPULATIONS 643162 Baseline Week 13 Recovery 643172 Baseline Week 13 Recovery 643195 Baseline Week 13 Recovery 643226 Baseline Week 13 Recovery 643237 Baseline Week 13 Recovery 643246 Baseline Week 13 Recovery 643253 Baseline Week 13 Recovery 643262 Baseline Week 13 Recovery 643303 Baseline Week 13 Recovery 643304 Baseline Week 13 Recovery sc SC u u < o5 qh QP-ij Zy << Z1 co ri D OJ HD eD H <C CO 00 10 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 ssuc 0. <H 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 IN MA MONITOR 2 3 cwo o H 2 o 3z HrOih OCoOh 3ix, W2 < u wIwX Q t--1 < 2 D 0 v'V" 1 0 00 1 0 10 011 00 1 0 10 00 1 00 1 011 00 1 000 011 0 10 0 10 011 0 '; '1 1 0 10 00 0 0 1 .V:-:: 1 000 011 011 000 00 1 000 000 0 11 0 11 0 11 0 11 Company Sanitized. Does not contain T S C A CBI 698 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group III: 25 mg/kg/day MANIPULATIONS IN MA MONITOR APPROACH AND TOUCH AUDITORY STIMULUS TAIL PINCH PUPILLARY RESPONSE DEFECATIO] URINATION 643173 Baseline Week 13 643179 Baseline Week 13 643180 Baseline Week 13 643228 Baseline Week 13 643240 Baseline Week 13 643264 Baseline Week 13 643272 Baseline Week 13 643290 Baseline Week 13 643292 Baseline Week 13 643308 Baseline Week 13 000 00 1 0 0 V /;.04;.; 000 00 000 000 00 0 000 000 000 000 000 000 000 000 000 0 00 0 00 000 0 ci/c 1 0l0 0i0 0l 1 0 0 :/ 1 00 1 0 :.-! 1 4 0 00 1 0 1 /::4 011 0 4 / t :'' 1 0 10 0 .//CL;:'. 1 0 11 011 0 11 !,;1:/ 1 000 0 c 4 /; 1 00 1 ,,ompany Sanitized. Does not contain T S C A CBI 699 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group V: 100mg/kg/day MANIPULATIONS 643175 Baseline Week 13 643224 Baseline Week 13 643243 Baseline Week 13 643247 Baseline Week 13 643250 Baseline Week 13 643257 Baseline Week 13 643275 Baseline Week 13 643311 Baseline Week 13 643314 Baseline Week 13 643318 Baseline Week 13 a b a au O2 O< oH Dh CL. B2 << > CO Pi 2 O _) H2 QS 2< HCO 00 a u E < 0 00 0 000 000 -1 0 0 000 00 0 000 000 00 1 00 0 00 0 000 000 00 0 000 000 000 000 IN MA MONITOR >< 2 o2 HO i2 Hd ocu Oh CO 2a- 2W < u wtwu Q H < 2 2 2 0 1. 1 0 11 000 00 1 0 11 0 10 000 0 10 0 10 00 1 0 1l 0 11 000 0 ; 1: 1 0 11 0 10 000 0 1 .: ,1 0 10 a Sacrificed in e x tr e m is prior to evaluation. bAdditional observation noted - Sore, right axilla. 700 Company Sanitized. Does not contain T S C A C B f H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group VII: 250 mg/kg/day MANIPULATIONS 643151 Baseline Week 13 Recovery 643165 Baseline Week 13 Recovery 643220 Baseline Week 13 Recovery 643225 Baseline Week 13 Recovery 643234 Baseline Week 13 Recovery 643236 Baseline Week 13 Recovery 643258 Baseline Week 13 Recovery 643266 Baseline Week 13 Recovery 643296 Baseline Week 13 Recovery 643316 Baseline Week 13 Recovery a X u CO OD <o Ox q h HX &a. Ze 5 XH < < < CO X u g 52 X < H 0 00 0 00 0 00 00 0 0, 0 000 000 000 000 000 00 0 000 0 00 00 0 000 000 000 000 000 00 0 00 0 000 000 00 0 0 00 00 0 00 0 00 0 000 000 IN MA MONITOR OX2' wco z OXS3h OD/h3 PDh Otthj 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 oz Ho uw<Xw Q H < z 2 D 1 1 1 1: 0 0 0 1 1 1 10 1Q 11 01 10 11 10 11 01 00 00 10 00 00 11 11 11 00 11 11 11 10 10 11 01 Additional observation noted - Ptosis. Company Sanitized. Does not contain T S C A CBI 701 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group II: 0 mg/kg/day MANIPULATIONS IN MA MONITOR TAIL PINCI PUPILLARE RESPONSE URINATIOI 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery a tB U yD <o 2Bh n POh( H*7 << vi 04 3 O hJ 2< pV"i 00 00 00 00 00 00 00 00 00 00 00 0 L,L;0. 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 0 0 0 0 0 0 yy 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 H < U w Bh w Q 00 00 01 00 00 0 0 1 1 0 00 1 00 0 011 00 1 011 00 1 00 1 011 0 11 00 I 0 10 00 1 0 10 000 00 0 011 000 000 00 1 00 0 00 1 000 00 0 000 Sacrificed in e x tr e m is prior to evaluation. Company Sanitiaed. Dooa nol contain T S C A CBI 702 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group IV: 25 mg/kg/day MANIPULATIONS 643321 Baseline Week 13 643324 Baseline Week 13 643364 Baseline Week 13 643380 Baseline Week 13 643389 Baseline Week 13 643390 Baseline Week 13 643396 Baseline Week 13 643410 Baseline Week 13 643433 Baseline Week 13 643458 Baseline Week 13 a 33 >" 00 o<Q os H C<u3 Q <3 3 3) OJ HD 5s O<3 ihn 00 3u*73 p. d<H3 0 000 000 000 00 0 000 000 000 00 0 000 00 0 00 0 000 000 00 0 000 000 000 000 IN MA MONITOR 233 ma HdcJl, Oi2an3, 3p3, W2 o2 QH<uwCCLI3I 2o H<23 2D 00 0 0 0 0 0 0 0 VV.3: 0 0 0 0 0 0 0 0 0 0 0 0 0: 0 00 11 01 0 :: 1 01 0l 00 00 00 11 00 11 00 1 :. 1 00 00 00 a Sacrificed in e x tr e m is prior to evaluation. Comp.ni, Sanitized. Does noicontalo tsca CBI 703 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VI: 100mg/kg/day MANIPULATIONS 643322 Baseline Week 13 643323 Baseline Week 13 643366 Baseline Week 13 643367 Baseline Week 13 643392 Baseline Week 13 643409 Baseline Week 13 643461 Baseline Week 13 643462 Baseline Week 13 643472 Baseline Week 13 643489 Baseline Week 13 X u X u D <o a0*< o H Pi << >* m O Dj HD 5<! P co X Cl"7J ecu -j <H 000 000 000 000 000 000 000 000 000 000 00 1 000 000 000 000 0 -1 0 0 0V 0 000 000 000 IN MA MONITOR 2o z T5 Kco H o j2daj. bOZco, Da, 2W < wuwu* Q p < z 5 D 00 0 00 0 o11 0 10 00 1 011 000 0 11 00 1 00 0 000 010 000 00 0 0 : 1. ; 1 000 0 :0 1 00 1 000 000 Company Sanitized. D oes nof contain TSCACBI 704 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VIII: 250 mg/kg/day MANIPULATIONS APPROACH AND TOUCH AUDITORY STIMULUS 643345 Baseline Week 13 Recovery 643347 Baseline Week 13 Recovery 643351 Baseline Week 13 Recovery 643358 Baseline Week 13 Recovery 643423 Baseline Week 13 Recovery 643441 Baseline Week 13 Recovery 643444 Baseline Week 13 Recovery 643456 Baseline Week 13 Recovery 643474 Baseline Week 13 Recovery 643481 Baseline Week 13 Recovery a b b a,c sc u 5EC <H 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 000 00 1 000 000 000 000 000 000 000 IN MA MONITOR S<GdC! (zp^oW* pa. 2w 2 o H < uwPwc Q 2 o <g 2 p 01 01 00 0 ,0 00 00 00 00 00 01 01 00 01 00 00 :0 0 00 00 0 :V.e 1 ; 01 00 01 01 00 00 00 01 01 01 00 1 1 0 0 0 0 1 0 1 1 0 0 1 0 0 1 1 0 1 1 1 1 0 1 1 0 0 1 1 0 aAdditionalobservationnoted- Scratch,rightcomer ofeye. bAdditionalobservationnoted- Ptosis. cAdditionalobservationnoted- Chromodacryorrhea. 705 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENTS Company Sanitized. Does not contain T S C A CBI 706 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 553 485 447 80 19 27 1611 389 209 193 10 6 0 807 397 401 306 291 44 1 1440 492 436 408 360 127 10 1833 500 299 286 319 235 84 1723 401 292 241 306 179 34 1453 443 287 247 212 41 165 1395 365 204 193 66 1 5 834 339 161 234 156 34 10 934 425 359 194 70 17 0 1065 Male Rats/Group III: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 123 4 5 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 391 252 69 23 429 322 331 56 391 306 296 5 361 282 299 35 388 306 171 34 486 468 485 259 403 245 54 6 387 268 172 100 487 382 305 160 464 454 386 189 0 2 5 5 1 45 1 12 9 26 6 Total 6 741 0 1140 9 1012 0 982 1 901 8 1751 1 710 1 940 20 1363 3 1522 Company Sanitized. Does not contain T S C A CBI 707 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Male Rats/Group V: 100mg/kg/day Animal Number Successive 10-Minute Intervals 2 3 4 5 6 Total 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 454 386 370 122 5 3 1340 443 385 344 399 260 258 2089 424 278 257 151 29 4 1143 368 299 153 17 0 2 839 329 241 135 77 1 6 789 366 262 53 5 30 0 716 488 406 76 3 32 183 1188 372 304 277 113 37 53 1156 432 366 113 49 17 11 988 353 292 185 24 6 17 877 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 234 5 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 357 267 213 33 0 454 366 366 239 256 434 271 90 10 415 267 232 124 102 405 336 298 195 49 312 309 147 1 38 305 159 129 12 1 375 255 251 107 0 434 361 10 6 26 433 280 41 11 0 6 Total 0 870 120 1801 0 796 24 1164 60 1343 238 1045 6 612 2 990 2 839 5 770 Company Sanitized. Does not contain T S C A C B l 708 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group II: Omg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 389 440 249 27 0 1 1106 384 279 289 221 11 3 1187 316 184 10 181 93 9 793 300 236 133 196 220 20 1105 341 260 254 257 160 42 1314 374 272 47 7 168 27 895 459 419 119 301 189 7 1494 381 257 222 214 208 193 1475 401 388 280 209 25 0 1303 364 305 26 46 230 11 982 Female Rats/Group IV: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 12 3 4 5 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 361 290 261 222 11 371 335 330 298 276 439 287 195 53 0 388 212 189 29 237 384 307 181 268 162 382 160 224 273 164 407 278 282 87 8 415 366 376 111 5 412 289 263 185 215 438 331 193 2 8 6 Total 5 1150 110 1720 8 982 102 1157 32 1334 1 1204 50 1112 0 1273 7 1371 7 979 Company SanMWtf. Does no. contain t s c a c b i 709 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ^ INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group VI: 100mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 506 455 454 494 438 420 2767 351 294 74 0 10 37 766 458 369 13 259 91 16 1206 425 368 210 112 42 19 1176 387 294 204 209 125 2 1221 431 391 232 257 72 5 1388 398 261 23 3 12 11 708 422 342 268 35 39 12 1118 348 297 62 18 10 6 741 362 198 153 133 85 262 1193 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 2345 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 416 324 320 390 348 278 251 185 48 7 339 290 312 363 341 380 361 120 5 68 320 189 245 162 209 356 244 112 10 7 331 77 342 268 40 413 276 276 148 5 382 284 63 5 0 428 318 248 238 18 6 Total 351 2149 1 770 225 1870 1 935 73 1198 3 732 0 1058 75 1193 4 738 2 1252 i- Company Sanitized. Does not contain T S C A CBI 710 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 485 417 231 56 55 19 1263 419 268 252 190 205 153 1487 378 263 260 187 226 209 1523 430 316 297 303 121 220 1687 434 265 231 171 171 277 1549 384 295 231 156 83 9 1158 429 304 294 201 14 127 1369 354 277 185 139 51 2 1008 383 291 131 133 75 2 1015 370 316 214 203 155 1 1259 Male Rats/Group III: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 12 34 5 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 301 260 226 114 4 421 316 224 206 176 366 301 336 329 133 329 173 182 217 155 369 253 190 181 128 458 363 207 168 184 398 287 126 15 11 368 260 127 4 7 430 361 326 165 10 478 397 237 322 183 6 Total 32 937 56 1399 88 1553 171 1227 101 1222 102 1482 63 900 4 770 54 1346 47 1664 Company Sanitized. Does not contain T S C A CBI 711 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 .S#*"***!. INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group V: 100mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643175 a 643224 643243 643247 643250 643257 643275 643311 643314 643318 384 303 252 234 147 98 1418 351 218 270 249 183 186 1457 361 229 41 9 0 25 665 340 260 207 212 182 186 1387 341 269 215 154 201 0 1180 405 368 313 321 337 178 1922 306 189 129 115 125 91 955 395 274 317 57 242 187 1472 431 345 353 267 123 265 1784 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 234 5 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 285 147 45 24 4 388 340 340 221 138 440 289 249 228 155 296 223 250 183 213 299 71 6 3 64 395 298 230 135 138 304 300 156 150 92 357 236 177 115 120 438 399 369 305 240 482 345 279 105 288 6 Total 3 508 132 1559 29 1390 66 1231 13 456 28 1224 212 1214 16 1021 160 1911 269 1768 Sacrificed in e x tre m is prior to evaluation. com pany Sanitized. Does not contain TS CA CBI 712 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 433 296 197 189 77 50 1242 402 270 321 167 191 269 1620 315 204 242 127 66 284 1238 321 215 277 217 190 152 1372 402 265 220 205 141 12 1245 399 332 255 283 160 152 1581 453 370 359 148 2 0 1332 278 192 122 21 23 3 639 378 206 63 4 123 0 774 340 280 172 115 103 242 1252 Female Rats/Group IV: 25 mg/kg/day Animal Number Successive 10-Minute Intervals I 234 5 643321 a 643324 643364 643380 643389 643390 643396 643410 643433 643458 499 346 306 315 361 427 407 247 252 18 396 231 202 196 102 428 376 306 148 22 382 278 246 87 154 520 429 226 20 64 420 372 304 249 138 336 133 29 199 11 476 335 282 29 37 6 Total 258 2085 114 1465 102 1229 111 1391 154 1301 136 1395 222 1705 8 716 270 1429 Sacrificed in e x tre m is prior to evaluation. ompany Sanitized. Does not contain T S C A CBI 713 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Female Rats/Group VI: 100 mg/kg/day Animal Number 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Successive 10-Minute Intervals i 2 3 4 5 6 Total 521 376 401 380 66 5 1749 312 184 17 1 0 115 629 412 350 309 245 245 256 1817 456 347 241 215 297 42 1598 288 176 106 47 79 32 728 448 300 231 270 18 161 1428 386 265 330 177 17 181 1356 393 328 226 32 245 115 1339 294 157 130 71 158 121 931 350 178 27 1 211 82 849 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 426 227 15 168 232 244 177 118 130 111 392 347 248 83 81 350 263 129 185 81 367 223 133 87 15 308 246 97 114 145 471 407 267 117 45 445 249 298 296 153 387 261 28 4 38 321 277 148 207 212 6 Total 255 1323 26 806 237 1388 9 1017 14 839 2 912 96 1403 63 1504 149 867 54 1219 ;ompany Sanitized. Does not contain T S C A CBI 714 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Recovery Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 279 187 123 77 85 82 833 423 233 154 111 170 173 1264 311 174 130 131 92 101 939 296 154 52 138 91 137 868 236 187 109 107 92 64 795 332 278 160 111 154 98 1133 329 157 164 197 147 215 1209 384 249 194 222 126 215 1390 268 158 118 129 58 108 839 382 246 199 222 192 205 1446 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals 1234 5 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 278 193 174 150 117 321 220 137 210 174 310 201 213 114 135 232 192 202 193 139 197 168 99 53 67 302 177 133 82 207 388 272 137 169 99 289 153 59 130 44 328 142 188 127 109 304 126 132 85 113 6 Total 111 1023 192 1254 168 1141 110 1068 3 587 54 955 193 1258 70 745 137 1031 125 885 Company Sanitized. Does not contain T S C A CBI 715 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Recovery Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643330 643336 a 643377 643387 643405 643415 643425 643426 643448 643453 307 160 146 132 74 201 1020 381 246 201 168 169 128 1293 315 185 191 109 79 155 1034 208 137 167 65 110 17 704 384 316 221 262 79 1 1263 322 262 127 71 117 90 989 330 228 160 198 76 139 1131 333 204 177 171 72 110 1067 387 267 166 234 174 90 1318 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 2345 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 269 25 39 0 0 294 146 194 95 50 328 220 132 55 31 267 166 38 120 60 379 254 233 254 49 254 110 27 69 17 345 216 38 76 73 185 56 29 0 1 325 185 211 61 18 327 152 112 127 113 6 Total 97 430 33 812 192 958 22 673 187 1356 112 589 15 763 77 348 114 914 75 906 Sacrificed in e x tr e m is prior to evaluation. Company Sanitized. Does not contain T S C A CBf 716 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS Company Sanitized. Does not contain TSCA CBI 717 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 57 68 81 23 3 124 130 141 16 13 124 113 143 124 42 88 93 100 109 79 96 103 119 115 133 128 135 112 120 111 133 130 142 134 51 161 136 140 68 4 146 121 144 98 32 144 117 116 72 21 4 236 2 426 4 550 10 479 51 617 37 643 76 666 4 513 13 554 0 470 Male Rats/Group III: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 12 3 4 5 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 128 143 75 14 122 134 147 37 110 128 105 8 146 120 137 31 141 127 121 23 66 62 65 56 136 135 52 14 119 147 118 99 91 102 140 106 109 114 112 116 0 3 5 6 3 10 2 18 8 32 6 Total 9 369 0 443 13 369 0 440 5 420 4 263 6 345 6 507 11 458 3 486 Company Sanitized. Does not contain TS CA CBI 718 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Male Rats/Group V: 100mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 93 97 142 81 6 11 430 107 121 134 114 137 116 729 135 145 146 95 28 5 554 121 130 115 22 1 2 391 127 109 118 62 4 13 433 145 151 57 9 28 1 391 111 117 58 8 26 78 398 141 154 140 90 38 26 589 112 151 89 30 19 14 415 140 154 112 39 12 19 476 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 156 181 134 54 1 130 139 171 167 155 124 121 54 4 1 141 141 130 65 78 152 137 132 110 48 144 137 124 7 21 142 124 93 23 3 143 138 145 95 4 122 155 12 9 11 125 130 25 7 1 6 Total 0 526 90 852 0 304 15 570 64 643 145 578 6 391 5 530 9 318 8 296 Company Sanitized. Does not contain T S C A CB! 719 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 121 124 130 28 2 4 409 136 147 125 127 5 7 547 121 145 15 143 100 11 535 153 131 108 132 135 28 687 142 125 128 126 139 37 697 145 159 47 14 142 40 547 105 109 79 115 94 10 512 151 151 140 100 136 125 803 125 125 142 125 20 4 541 137 150 24 37 155 15 518 Female Rats/Group IV: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 .3 4 5 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 161 138 159 148 19 141 167 156 174 168 106 124 100 32 2 120 106 130 38 106 129 149 129 158 128 136 114 138 161 99 122 148 149 72 9 146 151 122 88 11 120 149 152 126 92 121 122 117 4 8 6 Total 7 632 104 910 8 372 72 572 28 721 3 651 31 531 2 520 12 651 12 384 Company Sanitized. Does not contain T S C A CBI 720 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group VI: 100mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 72 67 73 75 69 78 434 136 125 71 1 15 23 371 109 155 13 95 55 14 441 80 124 122 82 34 16 458 149 162 127 147 115 3 703 118 137 107 131 50 9 552 132 124 17 7 8 13 301 139 131 113 31 25 18 457 155 127 50 19 15 12 378 142 114 103 75 63 150 647 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 136 161 152 146 166 129 134 157 51 9 147 154 172 138 126 155 139 94 6 54 140 143 129 143 146 152 163 107 11 16 125 46 131 149 35 132 105 133 124 11 121 135 58 6 0 118 144 134 129 25 6 Total 164 925 3 483 146 883 4 452 77 778 5 454 1 487 59 564 7 327 4 554 Company Sanitized Does not contain TSCACBK 721 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 58 66 42 14 9 3 192 134 125 139 113 115 95 721 150 127 106 99 125 138 745 121 113 104 131 56 95 620 107 112 102 77 84 119 601 124 119 109 84 53 11 500 122 139 138 107 21 70 597 154 166 135 106 48 7 616 172 154 94 103 77 8 608 142 133 121 114 97 2 609 Male Rats/Group III: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 1234 5 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 127 126 126 60 8 118 81 109 82 101 128 110 99 105 66 160 90 103 95 100 141 127 121 96 65 98 112 89 88 81 143 132 72 6 9 148 126 101 58 129 115 142 98 15 97 126 94 84 64 6 Total 32 479 24 515 51 559 88 636 83 633 48 516 51 413 4 392 32 531 24 489 ompany Sanitized. Does not contain T S C A CBf 722 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 .JH-- INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group V: 100 mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643175 a 643224 643243 643247 643250 643257 643275 643311 643314 643318 133 144 133 101 113 63 687 161 142 162 164 142 151 922 139 130 34 2 2 16 323 158 121 119 112 109 123 742 204 174 132 87 154 1 752 123 115 108 121 120 85 672 167 127 97 110 111 75 687 137 123 135 33 126 99 653 138 147 153 136 91 140 805 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 162 97 47 28 6 120 127 129 95 73 139 139 124 121 102 144 118 138 114 132 132 60 6 5 54 155 144 129 92 93 143 150 103 123 74 131 141 102 65 69 110 111 101 101 106 109 128 96 59 146 6 Total 6 346 78 622 39 664 56 702 14 271 31 644 122 715 9 517 86 615 114 652 a Sacrificed in e x tr e m is prior to evaluation. Company Sanitized. Does not contain T S C A CBI 723 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals I 2 3 4 5 6 Total 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 139 124 69 84 52 36 504 131 127 137 81 88 135 699 150 113 131 80 87 140 701 161 147 146 142 113 123 832 147 114 128 112 95 11 607 157 158 159 154 135 142 905 117 115 133 97 5 5 472 166 130 117 25 31 6 475 122 141 66 8 73 1 411 141 149 111 93 31 145 670 Female Rats/Group IV: 25 mg/kg/day A nim al Number Successive 10-Minute Intervals I 234 5 643321 a 643324 643364 643380 643389 643390 643396 643410 643433 643458 125 134 129 146 134 122 130 109 119 14 135 114 98 109 87 152 162 154 107 26 153 127 153 65 121 49 67 31 4 8 123 128 151 137 105 139 92 18 123 12 113 133 115 26 26 6 Total 127 795 57 551 58 601 81 682 120 739 24 183 123 767 8 392 128 541 a Sacrificed in e x tr e m is prior to evaluation. 724 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Female Rats/Group VI: 100mg/kg/day Animal Number Successive 10-Minute Intervals i 2 3 4 5 6 Total 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 65 56 51 53 13 1 239 161 110 24 1 2 82 380 132 123 141 137 127 141 801 103 130 129 108 118 34 622 153 129 86 56 83 37 544 112 128 106 105 20 104 575 146 145 128 128 13 118 678 142 144 125 23 123 52 609 163 107 87 56 121 97 631 139 108 33 3 147 65 495 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 234 5 643345 643347 643351 643358 643423 643441 643444 643457 643474 643481 116 112 14 101 127 121 123 77 83 76 138 136 135 75 79 152 132 110 122 53 156 127 96 93 19 163 136 100 95 90 101 122 134 54 24 89 101 112 133 83 134 123 25 8 21 143 138 110 152 127 6 Total 101 571 23 503 135 698 18 587 25 516 7 591 58 493 43 561 96 407 48 718 Company San/Saed. Dons no. co ,,.a i,, t s c a C B , 725 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Male Rats/Group I: 0 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 3 4 5 6 Total 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 134 139 105 64 61 65 568 88 70 57 52 67 56 390 122 91 72 79 60 77 501 130 79 21 81 54 86 451 153 132 78 78 71 48 560 146 136 99 71 102 70 624 140 90 96 117 88 115 646 152 128 101 99 89 100 669 142 90 82 77 66 67 524 121 109 89 87 113 115 634 Male Rats/Group VII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 144 131 123 100 77 136 109 86 136 102 150 112 105 82 96 131 104 98 126 95 96 66 56 42 44 116 95 92 63 100 122 102 63 76 50 164 87 35 67 33 128 85 81 74 66 124 68 75 36 61 6 Total 87 662 118 687 115 660 88 642 7 311 39 505 90 503 49 435 93 527 72 436 D<"* contain TScA c m 726 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Female Rats/Group II: 0 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 3 4 5 6 Total 643330 643336 a 643377 643387 643405 643415 643425 643426 643448 643453 134 123 101 100 58 155 671 .. 126 132 98 114 116 102 688 152 118 132 101 70 126 699 126 106 113 69 102 14 530 135 152 129 155 66 5 642 139 132 108 76 92 84 631 157 130 84 129 62 104 666 145 151 127 126 64 104 717 130 129 105 119 87 55 625 Female Rats/Group VIII: 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 2345 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 153 18 30 0 137 103 112 78 154 138 99 43 142 126 56 101 117 118 117 122 142 85 38 50 149 144 55 62 125 45 29 1 149 125 126 66 136 109 82 93 0 47 42 52 42 22 89 3 28 85 6 Total 69 270 43 520 129 605 32 509 121 637 84 421 34 533 49 252 97 591 87 592 Sacrificed in e x tr e m is prior to evaluation. Company Sanitized. Does not contain T S C A CBI 727 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX K INDIVIDUAL CLINICAL PATHOLOGY DATA Company Sanitized. Does nof contain TSCA OBI 728 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS : General: ADEQ _ adequate CLOT - sample clotted DECK - decreased NSR _ no sample received for testing NT - not taken or not performed NT-HEMOL - not taken due to hemolysis greater than or equal to moderate OK - sample condition OK for testing QNS - quantity not sufficient RNV - result not valid UTD - unable to determine > - greater than < - less than Individual Hematology Values: COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count WBC - white blood cell count ANEU - absolute neutrophil (all forms) ANPR - absolute neutrophil precursor ALYM - absolute lymphocyte AMON - absolute monocyte AEOS - absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell ABLT - absolute blast leukocyte AMSC - absolute miscellaneous leukocyte PLT - platelet count SPEC - special observations AL - atypical lymphocyte HSN - hypersegmented neutrophil Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) ABBREVIATIONS : (Continued) Individual Red Blood Cell Morphology Values: NORM - normal ANIS - anisocytosis MIC " microcytes MAC - macrocytes POLY - polychromasia HYPO - hypochromas ia ECHI - echinocytes ACAN - acanthocytes TARG - target cells RX - rouleaux HJB - Howell-Jolly body SPEC - special observations -- - not observed or not examined; see whole blood sample condition Individual NORM W_hitneorBmlaolod Cell / Platelet Morphology Values: SM - smudge white blood cells DB - Dohle bodies PC - platelet clumps (graded as 1 if present at any level) GP - giant platelets BP _ bizarre platelets TOX VC _- toxic neutrophils vacuolated cytoplasm SPEC - special observations -- " not observed or not examined; see whole blood sample condition Individual Coagulation Values : PHEM ~ plasma hemolysis FLIP - plasma lipemia PICT - plasma icterus PT - prothrombin time APTT - activated partial thromboplastin time Company Sanili*,. Does noi on,,(a,, TSCA CBI 730 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) ABBREVIATIONS : (Continued) Individual Serum and Plasma Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT SDH - - alanine aminotransferase sorbitol dehydrogenase ALKP - alkaline phosphatas'e BILI - total bilirubin BUN - urea nitrogen CREA - creatinine CHOL - cholesterol TRIG - triglycerides GLUC - glucose TP - total protein ALB - albumin GLOB - globulin CALC - calcium IPHS - inorganic phosphorous NA - sodium K - potassium CL - chloride PHEM - plasma hemolysis from blood sample for fluoride determination FLIP - plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLL - plasma fluoride SPEC - special observations Individual Urinalysis Values: QUAL - quality (modifies color) COL - color CLAR - clarity VOL - volume UOSM - urine osmolality SG - specific gravity PH - the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET - ketone UBIL - urine bilirubin BLD - blood URO - urobilinogen UFLU - urine fluoride UMTP - urine protein SPEC special observations Individual Urine Microscopic Examination Values: EPIT - epithelial cells UWBC - urine white blood cells URBC - urine red blood cells NCRY - normal crystals MICR - microorganisms SPER sperm SPEC - special observations com pany Sanitized. Does not contain T S C A CBI 731 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) KEY: Red Blood Cell Morphology Values, White Blood Cell / Platelet Morphology Values exception of Platelet Clumps), and Special Observations: 1 - trace 2 - few 3 - moderate 4 - many (with the Urine Microscopic Values: EPIT per high power field (40x) few 1-10 moderate 11-50 many >50 NCRY/MICR per high power field (40x) few - 1-25%/field moderate - 26-50%/field many - >50%/field SPERM/MUCUS per low power field 1 - 1-5 2 - 6-20 3 - >20 NOTES: When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records: the sample was clotted (for hematology or coagulation data) there was insufficient sample for analysis (QNS) a valid result could not be obtained (RNV) the sample was not suitable for evaluation the animal died prior to sample collection no sample was available for analysis (NSR) (CLOT) When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data. Company Sanitized. Does not contain T S C A CBI 732 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number COND RBC xlOA6/uL HGB g/dL Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 OK 7.72 14 .4 OK 7.77 15..1 OK 8.21 14 .7 OK 8.64 15 .2 OK 8.18 15,.1 OK 7.79 14 .9 OK 8.04 14 .9 OK 8.37 15 .8 OK 8.51 15 .1 OK 8.96 16 .0 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 OK 8.38 15..7 OK 8.48 15..6 OK 7.97 14..6 OK 8.09 15..0 OK 8.38 15,.5 OK 8.16 15..2 OK 8.67 15..6 OK 8.62 15..7 OK 8.42 14..8 OK 8.18 15..6 Individual Hematology Values HCT % MCV fL MCH pg MCHC g/dL 44..3 44..9 45 .2 46 .4 46..4 45 .9 43 .7 48..0 45 .8 49 .6 49..0 46,.9 44,.2 46.,3 46..3 44..2 47..2 47 .9 46.,1 47.,4 57..3 57..7 55 .0 53..7 56..7 58 .9 54 .4 57..4 53 .8 55..4 58 ,.5 55..4 55..5 57..2 55..2 54 .,2 54 .5 55.,6 54..8 57..9 18..7 19..4 18,.0 17,.6 18..5 19..1 18 .5 18.,8 17..7 17..9 18..7 18..4 18..3 18. 6 18..5 18..6 18. 0 18.,2 17. 6 19. 0 32..6 33..7 32..7 32..8 32..6 32 .4 34 ,0 32..9 32 ,.9 32.,3 32.0 33.2 33.0 32.5 33.4 34.3 33.1 32.8 32.1 32.9 RDW ARET WBC ANEU % xlO-3/uL x!0A3 /uL xlO"3/uL 12 .4 11..8 12..0 12,.2 12 .1 13 .2 11..9 12 .3 11..5 12 .3 11.9 11.6 12.4 12.0 11.2 12.6 11.7 11.7 12.7 12.7 195. 161. 199. 205. 177 . 299. 199. 157. 189 . 215. 17..56 17..58 16,.96 20..09 18..01 19..39 17..08 12..22 16..01 18..65 198 . 188. 201. 177. 146. 216. 141. 163 . 176. 248. 10.72 14.36 11.81 20.04 14.73 22.72 21.83 16.64 13.63 16.95 4..31 1 ..86 1,.09 3 ,.02 1..32 2..73 2 .88 1 ..10 2..57 2..30 2.73 1.97 2.88 4.03 1.43 1.62 2.26 1.79 2.13 2.29 CompanySanitized. Does n,,. es not contain TSCACBI 733 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO^/uL HGB g/dL Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 OK 8..02 15.1 OK 8 .24 14.7 OK 8 .05 15.2 OK 7 .76 14.7 OK 8 .09 15.6 OK 7,.76 15.0 OK 8 .65 16.1 OK 7 .33 14.2 OK 7,.69 14.4 OK 8 .01 15.6 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 OK 8,.40 14.9 OK 8 ,.13 14.9 OK 7,.85 14.7 OK 8,.31 14.9 OK 8 .30 14.6 OK 8 .03 14.6 OK 7 ,.59 14.7 OK 8,.27 15.1 OK 7 ,.46 13.9 OK 8..26 15.3 Individual Hematology Values HCT % MCV fL MCH pg mchc g/dL 46.1 45.2 47.1 43.3 47.7 45.7 49.1 42.4 44.4 47.2 45.9 44.6 44.8 46.3 45.4 44.7 43.9 45.7 42.7 48.0 57.5 54.8 58.5 55.8 58.9 59.0 56.8 57.8 57.7 58.9 54.6 54.9 57.1 55.7 54.6 55.7 57.8 55.2 57.2 58.1 18.9 17.9 18.9 19.0 19.3 19.3 18.7 19.4 18.8 19.5 17.7 18.3 18.7 18.0 17.6 18.2 19.4 18.2 18.6 18.6 32.8 32.6 32.3 34.0 32.8 32.7 32.9 33.5 32.5 33.1 32.4 33.3 32.8 32.3 32.1 32.7 33.5 33.0 32.5 31.9 DuPont-5386 rdw aret wbc aneu % xlOA3/uL xlO'-/uL x l O ^ / u L 10.8 11.7 11.7 11.4 12.1 11.5 12.5 12.6 12.5 12.1 13.0 12.4 13.3 12.3 12.7 12.4 12.9 11.8 12.7 12.6 186. 154. 203 . 141. 164. 180. 204. 196. 181. 179. 17.39 13.60 21.89 15.34 23.11 14.52 16.25 24.17 14.81 18.65 202 . 154. 169. 188. 121. 207. 184. 185. 164. 191. 20.43 21.85 25.34 20.48 14.70 20.74 18.75 16.92 16.73 16.93 3.09 2.04 3.21 3.53 2.07 2.00 1.31 2.11 3.45 2.21 3.35 4.80 2.66 2.14 1.45 2.52 2.19 2.09 1.83 1.77 Company Sanitized. Does no! contain TSCACBJ 734 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xl0A3/uL ALYM xlO-3/uL AMON xlO A3/uL Individual Hematology Values AEOS ABAS ALUC xl0A3/uL xl0A3/uL xl0A3/uL ABLT '3/uL AMSC xlOA3/uL PLT xlOA3/uL Male, Group:; I - 0 mg/kg - Day 44 643143 NT 12 ,.33 0 .34 0 .20 0..10 0..28 NT NT 1070 643150 NT 14..86 0,.36 0 .11 0 .17 0 ,.22 NT NT 1229 643185 NT 15..11 0,.21 0 .19 0 .08 0 .29 NT NT 1028 643189 NT 16..05 0..57 0 .20 0..08 0..17 NT NT RNV 643204 NT 15..87 0,.30 0 .14 0..12 0 .25 NT NT 1242 643205 NT 15 .84 0 .23 0 .11 0..16 0 .33 NT NT 1190 643235 NT 13 .44 0..30 0 .12 0,.10 0 .24 NT NT 1179 643241 NT 10..41 0,.30 0 .19 0..08 0..14 NT NT 947 643288 NT 12 .56 0 .44 0 .11 0 ,.11 0 .22 NT NT 1232 643300 NT 15..47 0,.31 0 .19 0 ,.09 0..29 NT NT 1149 Male, Group:: III - 25 mg /kg - Day 44 643173 NT 7,.30 0 ,.33 0..22 0 .,03 0,.11 NT NT 940 643179 NT li..53 0..43 0..19 0 .09 0 .15 NT NT 1171 643180 NT 7..94 0..45 0..31 0..07 0..16 NT NT 992 643228 NT 14 .39 0..62 0 .16 0..09 0 .75 NT NT 1161 643240 NT 12..52 0..32 0..19 0,,08 0..20 NT NT 1133 643264 NT 20..17 0 .37 0 .19 0..11 0 .26 NT NT 1102 643272 NT 18 .39 0..41 0..22 0..17 0..38 NT NT 1119 643290 NT 13 .66 0 .50 0..23 0. 11 0.,35 NT NT 1128 643292 643308 NT 10..65 NT 13..74 0..30 0 .31 0..26 0..30 0.,11 0. 13 0 .18 0..18 NT NT NT 943 NT RNV DuPont-5386 SPEC Company antzed. Does no! contain T S C A CB! 735 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlOA3/uL ALYM xl0A3/uL ANON xl0A3/uL Individual Hematology Va AEOS ABAS ALUC xlOA3/uL xlOA3/uL xlOA3/uL Male, Group:: V - 100 mg /kg - Day 44 643175 643224 643243 643247 NT 13.19 NT 11.42 NT 17.83 NT 11.20 0.64 0.00 0.41 0.46 0.18 0.14 0.10 0.15 0.10 0.00 0.14 0.00 0.19 0.00 0.21 0.00 643250 643257 643275 643311 643314 643318 NT 20,.07 NT 11..57 NT 14..14 NT 20 .97 NT 10,.57 NT 15..57 0..28 0 .50 0..40 0 .53 0..29 0 .42 Male, Group: VII - 250 mg /kg - Day 44 643174 643193 NT 15.,84 NT 16..61 0..74 0..44 0 .25 0 .11 0 .13 0 .11 0 .17 0 .11 0..23 0 .00 0 .20 0..12 0..06 0..19 0..14 0,.11 0..10 0..00 0..25 0,.22 0..21 0..27 0..18 0 .23 0 .,17 0 .00 643194 643201 643215 643252 643259 643260 643298 643315 NT 21..54 NT 17 .41 NT 12 .45 NT 17..25 NT 15 .15 NT 14..00 NT 14..07 NT 14 .31 0 .45 0 .34 0 .32 0 .42 0 .61 0..39 0 .34 0,.39 0..13 0,.21 0 .18 0..18 0 .15 0..13 0..16 0. 08 0..15 0,.12 0..06 0 .11 0..13 0..07 0.,16 0. 08 0.,41 0..27 0..24 0..26 0..52 0..23 0..17 0..30 lues ABLT xlO^/uL AMSC xlOA3/uL PLT xlO^/uL DuPont-5386 SPEC NT NT 1384 NT NT 1012 NT NT RNV NT NT RNV 5%-AL, absolute AL = 0.77; 2%-HSN, absolute HSN = 0.31 NT NT 762 NT NT 977 NT NT 920 NT NT 1271 NT NT 1315 NT NT 913 NT NT RNV NT NT 963 1%-AL, absolute AL = 0.22; 2%-HSN, absolute HSN = 0.44 NT NT 1032 NT NT 1163 NT NT 861 NT NT RNV NT NT 1122 NT NT 1049 NT NT 941 NT NT 936 Com pany Sanitized. Does not contain TS C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO~6/uL HGB g/dL Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 OK OK CLOT OK OK OK OK OK OK OK 8.26 8.55 NT 9.10 8.76 7.86 9.16 9.49 9.30 9.43 14.5 15.3 NT 14.9 15.5 14.3 15.5 16.6 15.5 15.8 Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 OK OK OK OK OK OK CLOT OK OK OK 9.22 8.47 8.59 7.81 8.70 8.29 NT 8.80 8.62 8.64 16.8 14.8 14.9 14.0 15.4 14.7 NT 15.2 14.7 15.8 Individual Hematology Values HCT MCV MCH % fL p g MCHC g/dL 46.9 48.4 NT 46.7 50.1 45.4 49.4 54.6 49.8 49.0 53.6 45.6 46.0 43.3 47.7 46.3 NT 47.8 46.7 49.9 56.8 56.6 NT 51.4 57.2 57.9 54.0 57.5 53.5 52.0 58.1 53.8 53.6 55.4 54.8 55.8 NT 54.3 54.2 57.8 17.5 17.9 NT 16.4 17.6 18.3 16.9 17.5 16.7 16.7 16.2 17.4 17.3 17.9 17.6 17.8 NT 17.3 17.1 18.3 30.9 31.6 NT 31.9 30.9 31.6 31.3 30.4 31.2 32.2 31.3 32.4 32.4 32.3 32.2 31.8 NT 31.8 31.5 31.7 I DuPont-5386 RDW ARET WBC ANEU % x!0A3/uL xl0A3/uL xlOA3/uL 13.5 12.3 NT 13.7 13.2 14.7 13.1 12.8 12.7 12.7 12.5 13.5 13.1 12.8 12.4 13.0 NT 13.0 12.9 12.8 188 . 125. NT 186. 213 . 274 . 187. 183 . 102. 168. 16.37 12.57 NT 17.83 14.95 12.84 15.69 13.88 14.13 11.10 163 . 162 . 173 . 175. 175. 227. NT 180. 153 . 206. 9.76 10.74 9.21 15.30 12.61 19.00 NT 11.14 10.07 11.56 2.62 1.26 NT 2.56 2.05 2.31 2.24 2.09 2.54 1.55 2.05 1.71 2.24 2.91 2.08 1.71 NT 1.36 1.56 1.62 Company Sanitized. Does not contain T S C A CBI 737 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 Animal Number COND RBC xlO^/uL HGB g/dL Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR OK OK OK OK OK OK , OK OK OK NT 8.23 8.33 7.67 8.15 8.27 9.03 8.29 8.29 8.15 NT 14.3 15.2 14.2 15.1 15.1 15.9 15.1 14.8 15.0 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 OK 8.64 14.6 OK 7.67 14.0 OK 8.12 14.5 OK 8.04 13.8 OK 8.18 14.5 OK 7.82 14.1 OK 8.20 15.3 OK 8.41 15.2 OK 7.12 12.5 OK 7.70 14.0 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL NT 45.1 47.4 44.1 46.1 47.5 51.3 48.8 46.7 47.4 45.6 44.0 46.2 43.7 46.6 45.9 49.1 48.4 40.2 44.2 NT 54.8 56.9 57.5 56.5 57.4 56.8 58.8 56.3 58.2 52.7 57.3 56,9 54.4 57.0 58.7 60.0 57.6 56.4 57.4 NT 17.4 18.2 18.5 18.5 18.2 17.6 18.2 17.9 18.4 16.9 18.2 17.9 17.2 17.8 18.0 18.6 18.0 17.5 18.2 NT 31.7 32.0 32.2 32.8 31.7 31.0 30.9 31.8 31.5 32.1 31.9 31.5 31.6 31.2 30.7 31.1 31.3 31.1 31.8 RDW ARET WBC ANEU % xlOA3/uL x l O ^ /uL x!0^3/uL NT 13.4 13.1 12.8 13.5 13.3 13.0 14.0 14.2 13.8 15.0 15.9 15.0 14.1 15.1 17.8 15.9 12.9 14.2 14.9 NT 153. 220. 238. 159. 185. 147. 237 . 203 . 222. NT 11.07 16.28 11.52 14.98 14.70 11.25 20.47 12.04 14.09 237 . 185. 229 . 177. 187. 280 . 296. 156. 194 . 240 . 14.74 13.94 22.55 17.74 12.04 16.27 15.77 12.07 13.01 14.41 NT 1.66 2.21 2.00 1.69 1.03 0.56 1.23 2.97 2.44 3.10 1.68 3.02 2.70 1.66 2.47 1.26 3.14 2.21 2.17 Com pany Sanitized. Does no! contain T S C A CBI 738 I! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlOA3/uL ALYM xlOA3/uL AMON xlO''3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xlO~3/uL xlOA3/uL x l O ^ / u L x l O ^ / u L AMSC xl0"3/uL PLT xl0^3/uL Male, Group:: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 0.00 0.00 NT NT NT 0.00 NT NT 0.00 0.00 13.10 10.43 NT 14.20 12.29 10.40 12.36 11.03 11.02 8.99 0.49 0.75 NT 0.69 0.30 0.13 0.55 0.37 0.42 Q .33 Male, Group:: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 0.00 NT NT 0.00 NT 0.00 NT NT NT 0.00 7.22 8.43 6.32 11.17 9.78 17.10 NT 9.19 8.03 8.90 0.20 0.35 0.32 0.77 0.38 0.19 NT 0.30 0.24 0.69 0.16 0.13 NT 0.21 0.14 0.00 0.21 0.18 0.14 0.22 0.29 0.10 0.23 0.46 0.13 0.00 NT 0.09 0.12 Q .35 0.00 0.00 NT 0.07 0.07 0.00 0.07 0.09 0.00 0.00 0.00 0.05 0.03 0.00 0.07 0.00 NT 0.05 0.04 0.00 0.00 0.00 NT 0.10 0.11 0.00 0.26 0.12 0.00 0.00 0.00 0.11 0.08 0.00 0.18 0.00 NT 0.15 0.09 0.00 0.00 0.00 NT NT NT 0.00 NT NT 0.00 0.00 0.00 NT NT 0.00 NT 0.00 NT NT NT 0.00 0.00 0.00 NT NT NT 0.00 NT NT 0.00 0.00 0.00 NT NT 0.00 NT 0.00 NT NT NT 0.00 1251 1145 NT 854 1330 1216 1225 RNV 1227 RNV 925 1160 952 1157 1186 1055 NT 1175 861 1025 I DuPont-5386 Company Sanitized. Does not contain T S CA CBI 739 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlO''3/uL ALYM xlOA3/uL AMON xlO A3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xlOA3/uL xlOA3/uL xlOA3/uL xlOA3/uL AMSC xlO A3/uL PLT xlOA3/uL Male, Group: V - O O mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NT NT NT NT 0 .00 0 .00 NT NT NT NT 9 .10 13 .09 8 .72 12 .20 12 .64 10 .01 18..83 8 .43 11 .05 NT 0 .14 0 .51 0 .47 0 .18 0..74 0 .56 0 .21 0 .25 0 .27 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 0 .00 NT NT NT NT NT 0 .00 0 .00 0 .00 NT 10..76 11,.60 18..36 14 .26 9.,36 12 .81 13..40 8..69 10. 28 11..70 0..44 0..28 0..49 0 .34 0,.34 0..48 0..79 0..24 0..39 0..23 NT 0 .05 0..08 0 .19 0 .32 0..29 0 .11 0..21 0..20 0 .07 0..44 0..23 0..24 0 .21 0..34 0 .,15 0..32 0..00 0,.13 0 .08 NT 0.04 0.12 0.05 0.06 0.00 0.00 0.00 0.05 0.05 0.00 0.06 0.10 0.07 0.08 0.08 0.00 0.00 0.00 0.05 NT 0.08 0.27 0.08 0.53 0.00 0.00 0.00 0.14 0.22 0.00 0.08 0.34 0.15 0.26 0.28 0.00 0.00 0.00 0.18 NT NT NT NT NT 0.00 0.00 0.00 NT NT 0.00 NT NT NT NT NT 0.00 0.00 0.00 NT NT NT NT NT NT 0.00 0.00 0.00 NT NT 0.00 NT NT NT NT NT 0.00 0.00 0.00 NT NT 1037 1272 1172 928 RNV 885 1228 1246 970 RNV 1015 RNV 1245 1047 1177 RNV 1131 1153 1008 DuPont-5386 SPEC Company Sanitized. Does no?contain TSCACB! 740 II H-24516: Sabchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO rt6/uL HGB g/dL Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 OK 9.18 15.4 OK 8.85 14.8 OK 8.99 15.4 OK 8.87 16.0 OK 8.57 15.3 OK 9.63 16.2 OK 8.42 15.3 OK 8.57 15.5 OK 9.39 16.2 OK 8.84 15.9 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 OK 7.68 14.5 OK 8.01 14.8 OK 8.09 14.0 OK 8.01 14.4 OK 8.00 14.4 OK 7.49 13.5 OK 7.94 14.3 OK 7.71 13.1 OK 8.60 16.2 OK 8.17 13.9 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 47.8 46.3 46.4 49.9 47.5 51.0 47.6 47.0 51.0 48.9 44..2 44 .4 43 ,.3 44 .4 44..3 41,,1 44..4 39..7 50..1 42..7 52.0 52.3 51.7 56.3 55.4 52.9 56.6 54.9 54.3 55.3 57..6 55..4 53 .5 55..3 55..4 54..9 56..0 51..5 58..2 52..2 16.8 16.7 17.1 18.0 17.8 16.8 18.2 18.1 17.2 17.9 18 .9 18..4 17..3 17,.9 18.,0 18..1 18 ..0 17 .0 18.,8 17. 0 32..3 31..9 33 .1 32 .0 32..2 31,.8 32..2 32.,9 31..7 32,.4 32 .8 33 .2 32 .3 32 .4 32,.6 33 .0 32..1 32..9 32,.3 32..6 ) DuPont-5386 RDW ARET WBC ANEU % x!0"3/uL x!0A3/uL xlO"3/uL 14 .5 15,.2 13 .3 12 .6 13..4 12..9 14..0 13..4 14..1 12 .8 11 .5 12 .4 12 .9 13 .4 10 .8 14..9 12 .3 14 .3 11 .7 13..1 224 . 216 . 167 . 188. 171. 190. 231. 142. 205. 147. 10 .14 15..17 10..25 15..43 10..50 22 .15 12..06 11..33 14..34 9..75 132 . 174 . 180. 153 . 132 . 176. 124. 153 . 119 . 159. 14 .81 10..52 11..88 16..84 16,.97 11..62 8..94 9..06 12..94 18..72 3 .52 2 .88 1 .12 1..26 0..67 2..67 1..25 2..34 1..01 1.,17 3 .29 1..52 1..83 1..08 2 .71 2 .54 1..06 1,.31 1..83 2 .18 Com pany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlO A3/uL ALYM xlO~3/uL AMON xl0"3/uL Individual Hematology Values AEOS ABAS ALUC ABLT x l O ^ / u L x l O ^ / u L xlO"3/uL xlO~3/uL AMSC xl0~3/uL PLT xl0~3/uL Male, Group:; I - 0 mg/kg - Day 125 643162 NT 5.90 0.30 0.17 0.13 0.11 NT NT 1185 643172 NT 11.52 0.38 0.13 0.09 0.17 NT NT 1154 643195 NT 8.71 0.20 0.08 0.05 0.09 NT NT 1075 643226 NT 13.24 0.57 0.16 0.05 0.15 NT NT RNV 643237 NT 9.50 0.11 0.06 0.04 0.11 NT NT 1044 643246 NT 17.83 0.74 0.33 0.09 0.49 NT NT 872 643253 NT 10.32 0.15 0.10 0.09 0.15 NT NT 1172 643262 NT 8.47 0.26 0.10 0.06 0.10 NT NT 910 643303 NT 12.48 0.41 0.15 0.07 0.23 NT NT RNV 643304 NT 8.06 0.32 0.07 0.05 0.08 NT NT RNV Male, Group:: VTI - 250 mg/kg - Day 125 643151 NT 11.05 0.18 0.06 0.08 0.16 NT NT 1058 643165 643220 NT 8.45 0.26 0.09 0.05 0.16 NT 9.41 0.24 0.08 0.09 0.22 NT NT NT 1167 NT 1181 643225 NT 15.07 0.27 0.10 0.12 0.20 NT NT 1016 643234 b43236 643258 643266 643296 b4J J ib NT 13.30 NT 8.50 NT 7.47 NT 7.22 NT 10.59 NT 15.13 0.45 0.25 0.22 0.23 0.20 0.53 0.19 0.08 0.06 0.11 0.09 0.48 0.19 0.06 0.04 0.03 0.07 0 .10 0.13 0.19 0.08 0.17 0.15 0.30 NT NT NT NT NT NT NT 1099 NT RNV NT 940 NT 1148 NT 1088 NT 1035 DuPont-5386 Com pany Sanitized Does not contain T S C A CBI I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO^S/uL HGB g/dL male, Group: II - 0 mg/kg -- Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 OK 8..16 15..4 OK 8 ,.39 15..4 OK 8 ,.32 16,.2 OK 8,.39 15 .3 OK 7,.85 14 .8 OK 8,.32 16..2 OK 8,.26 15..4 OK 8,.12 15 .1 OK 8 .41 15..0 OK 8 ,.37 15 .4 male, Group: IV - 25i mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NT NT OK 7 ,.34 14..8 OK 7 .89 14 .9 OK 7 .65 14 .8 OK 7 ,.81 14 .6 OK 8..35 15 .4 OK 8 ,.24 14 .8 OK 7,.70 14 .4 OK 7 .86 14..7 OK 7 ,.85 14..9 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL 46.,2 48..3 47..4 46..3 45,.0 48 .5 46..6 47 .5 47 .1 46..0 NT 44..6 44..9 44..0 43 .9 49,.0 46..2 43..7 44 .4 43 .3 56 .6 57 .5 57 .0 55 .2 57 .4 58 .3 56 .4 58 .5 56 .0 55 .0 NT 60 .7 57 .0 57 .6 56 .2 58 .7 56 .i 56 .8 56 .5 55 .1 18.9 18.4 19.4 18.2 18.9 19.5 18.6 18.6 17.8 18.5 NT 20.1 18.8 19.3 18.7 18.5 18.0 18.7 18.7 19.0 33.4 32.0 34.1 33.0 33.0 33.4 33.0 31.9 31.8 33.6 NT 33.2 33.1 33.6 33.2 31.4 32.0 33.0 33.2 34.5 DuPont-5386 RDW ARET WBC ANEU % xlCT3/uL xlO^/uL xl0~3/uL 11.7 12.2 11.2 12.0 11.1 12.2 11.3 11.5 12.4 11.6 NT 12 .1 11..4 11,.8 11..9 12..6 11,.4 12,.6 11..4 11..8 220 . 222. 198 . 217. 199. 226. 148. 208. 240 . 203. 12.21 15.77 10.57 9.80 12.17 16.31 12.64 18.68 11.02 17.52 NT 251. 173 . 194. 225. 265. 196. 248. 168. 228. NT 11 .44 15 .43 9 .71 10 .05 15 .67 14 .41 17 .08 8 .74 12 .93 2.01 2.02 1.43 0.92 1.32 1.82 2.11 3.08 0.71 2.25 NT 0..78 1..71 1..81 2..00 1..25 1..85 2,.31 1..14 1..76 Company Sanltlaad. Dons no! contain T S C A CBI 743 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xl0~6/uL HGB g/dL Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 OK 7.93 14.9 OK 8.68 15.5 OK 7.86 14.9 OK 8.38 15.1 OK 9.03 15.9 OK 7.88 15.1 OK 7.65 14.9 OK 8.37 15.3 OK 7.85 14.5 OK 7.76 14.5 lale, Group: VIII - 250 mg/kg Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 OK 7.38 14 .0 OK 7.72 15..3 OK 7.00 13 .1 OK 7.58 14 .1 OK 8.61 15..0 OK 7.84 15..2 OK 7.97 14..7 OK 7.62 14..3 OK 8.25 14..7 OK 7.56 14 ,5 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 45.5 46.5 45.2 46.3 48.8 46.0 43.7 46.4 42.9 44.2 42 .4 45..1 40 .1 43 .3 46..9 45 ,3 44..5 43..6 47..3 44 ..0 57.4 53.6 57.4 55.2 54.1 58.3 57.1 55.4 54.7 56.9 57 .5 58 .4 57 .3 57..1 54,.5 57..8 55..8 57..3 57..3 58 .2 18.7 17.8 18.9 18.0 17.6 19.2 19.5 18.3 18.4 18.7 18.9 19.8 18.7 18.6 17.4 19.4 18.5 18.8 17.8 19.2 32..6 33..3 33..0 32..6 32,.6 32 .8 34..1 33 .0 33 .7 32..8 32.9 33.9 32.6 32.5 31.9 33.6 33.1 32.8 31.0 32.9 ) DuPont-5386 RDW ARET WBC ANEU % xlO~3/uL xlOA3/uL xlO'3/uL 11..5 11..7 12..4 11..2 11,.9 11,.9 10 .8 11..3 11..4 13..3 12.0 12.4 12.4 12.6 12.0 11.6 11.6 12.0 12.7 12.2 203 . 197. 229. 179. 198. 239 . 146. 156. 192 . 267. 10..40 16..42 12,.35 12,.34 13..56 8..85 14..80 18..99 15.,81 10..69 177 . 263 . 223 . 191. 249. 189. 174. 247. 241. 150 . 11.54 16.07 13.91 11.60 11.27 14.20 16.91 12.61 14.72 13.09 1..68 2 .00 1..09 1..66 2..15 0..43 2..06 2 .14 1..93 1..72 1.47 2.34 2.03 1.17 2.45 1.41 3.13 1.03 1.34 1.75 Company SanJBaod. Dona no. con.a,,, T S C A C B . )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ ) DuPont-5386 Animal Number ANPR xlOA3/uL AXjY M x!0^3/uL x l O ^ /uL Individual Hematology Values UjUL rtJDJj1 x!0A3/uL x!0^3/uL xlO~3/uL xlO~3/uL xlO~3/uL xlO^/uL Female, Group: II - 0 mg/kg -- Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NT 9 .36 NT 12 .77 NT 8 .39 NT 8 .37 NT 10 .25 NT 13 .33 NT 9 .76 NT 14 .71 NT 9 .76 NT 14 .31 0 .21 0 .29 0 .32 0 .29 0 .33 0 .44 0 .20 0 .41 0 .10 0 .32 Female, Group : IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NT NT NT NT 0,.00 NT NT NT NT NT 9..55 12..94 7..20 1 .56 14 .26 11..67 14 .03 7 .,08 10..38 NT 0 .16 0..33 0..26 0..22 0..16 0..40 0..28 0 ,.23 0..24 0.33 0.24 0.19 0.11 0.10 0.23 0.24 0.15 0.16 0.16 NT 0.16 0.17 0.12 0.06 0.00 0.07 0.10 0.10 0.15 0.06 0.16 0.06 0.02 0.06 0.19 0.07 0.11 0.07 0.22 NT 0.12 0.11 0.09 0.09 0.00 0.15 0.11 0.04 0.13 0.24 0.29 0.17 0.09 0.11 0.30 0.26 0.22 0.14 0.27 NT 0.67 0.16 0.23 0.12 0.00 0.27 0.25 0.15 0.27 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT 1173 1158 1060 1339 1092 ENV 1294 RNV RNV RNV NT 990 1090 878 1171 953 1514 994 903 1239 SPEC Company Sanitized. Does not contain T S C A CBI 745 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlQA3/uL ALYM xlQA3/uL AMON x!0A3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xlQA3/uL x!0A3/uL x!0~3/uL xlO '3/uL AMSC xlO~3/uL PLT xlOrt3/uL Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 NT 8.05 NT 13.25 NT 10.39 NT 9.77 NT 10.59 NT 7.99 0 .31 0,.40 0 .25 0,.32 0 .32 0 .14 0..13 0..36 0 .08 0..26 0..18 0..10 0..05 0..14 0,.18 0..13 0..14 0..05 0 .17 0..26 0..36 0..21 0 .17 0..14 NT NT NT NT NT NT NT 1098 NT 1100 NT 1047 NT 1253 NT 867 NT RNV 643461 643462 643472 NT 11.96 NT 15.65 NT 13.16 0 .40 0,.40 0,.25 0..19 0.,22 0..19 0..06 0..19 0 .09 0..13 0 ,.38 0..19 NT NT NT NT RNV NT 1147 NT 1076 643489 NT 8.26 0..30 0,.10 0..11 0..20 NT NT 1083 Female, Group: VIII - 250 mg/kg Day 45 643332 NT 9.51 0 .17 0 .16 0 .08 0 .13 NT NT 1141 643340 NT 12.93 0 .39 0 .13 0 .12 0 .16 NT NT 1019 643341 NT 10.89 0..44 0..21 0 .08 0 .28 NT NT RNV 643359 NT 9.62 0..41 0 .13 0..07 0..21 NT NT 1143 643370 NT 7.93 0.,34 0..16 0 .11 0..28 NT NT 1157 643404 NT 12.10 0..22 0..22 0..08 0 .16 NT NT 955 643408 NT 12.92 0..28 0..21 0..12 0..25 NT NT 999 643435 NT 10.81 0..21 0..14 0..15 0..26 NT NT 1090 643446 NT 12.63 0 .17 0..18 0..10 0..29 NT NT 894 643466 NT 10.54 0 .29 0 .23 0 .07 0..21 NT NT 1211 DuPont-5386 SPEC Company SawtfeeiOoe, n0f contain TSCA CBI 746 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO^/uL HGB g/dL Female, Group: II - 0 mg/kg -- Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 OK 8 .56 16.1 OK 8 .45 15.5 OK 7 .90 15.1 OK 8 .00 14.4 OK 8 .39 15.8 OK 8 .34 15.8 OK 8 .53 15.8 OK 8 .73 15.9 OK 8 .46 15.1 OK 8,.71 15.9 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NT NT OK 7 ,.78 15.4 OK 8..31 16.4 OK 8,.16 15.3 OK 7..84 14.7 OK 8..66 15.6 OK 8..02 14.5 OK 7..85 14.6 OK 7.,96 15.2 OK 8,.15 14.7 Individual Hematology Values HCT MCV MCH % fL p g MCHC g/dL 48.0 47.5 45.2 43.8 49.5 48.8 49.4 48.7 46.6 48.8 NT 46.6 45.2 46.8 44.7 50.2 45.0 43.4 45.5 44.0 56.0 56.2 57.3 54.7 59.1 58.5 57.9 55.7 55.0 56.0 NT 59.9 54.4 57.4 57.0 58.0 56.1 55.3 57.1 54.0 18.8 18.4 19.1 18.1 18.9 19.0 18.5 18.2 17.9 18.2 NT 19.9 19.7 18.8 18.7 18.1 18.1 18.6 19.1 18.0 33.6 32.8 33.4 33.0 31.9 32.5 32.0 32.7 32.5 32.5 NT 33.2 36.3 32.7 32.8 31.2 32.3 33.6 33.4 33.4 DuPont-5386 RDW ARET WBC ANEU % x!03/uL xlO"3/uL xlO"3/uL 11..1 11..8 11..0 11..6 10..7 11..8 11..3 11..2 11. 8 10 .,2 NT 11.1 10.7 11.5 11.2 11.9 10.9 11.2 11.7 11.5 115. 180 . 144. 144. 207. 166. 148. 147. 174. 80. 10..38 11 .59 7..82 6..65 9..21 11..70 9..64 11..28 10..60 10..71 NT 188. 121. 127. 116. 173. 117. 173 . 201. 193 . NT 9 .38 8 .88 8..05 8 .47 11,.66 9,.72 12..64 8,.03 11..89 1..21 1 .31 1..40 0..67 1..32 1..09 1..32 1..62 0..93 0..64 NT 0,.68 2 .08 1..56 1..47 0..83 1..75 1..64 1 .10 1,.99 Com pany Sanitized. Does not contain TSCA CBf II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO-'/uL HGB g/dL Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 OK 7..87 14 .7 OK 7 ,.18 14 .5 OK 7 ,.94 14 .7 OK 8,.51 15 .2 OK 9,.48 16 .3 OK 7 ,.81 14 .7 OK 7,.74 14 .9 OK 8,.41 15 .2 OK 8,.56 15 .3 OK 8,.16 15 .0 Female, Group: VIII 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 OK 7 ,.30 13 .6 NSR NT NT OK 7 ,.78 14,.1 OK 8 .02 14..6 OK 8.,19 14..3 OK 7.,66 14 ,4 OK 8..13 14..6 OK 8 .16 14..9 OK 7. 61 13..4 OK 7. 50 13..9 Individual Hematology Values HCT MCV MCH % fL pg MCHC g/dL 45 .3 48 .6 44 .7 46 .6 51..5 43 .6 44..0 46 .4 46 .6 45 .1 42 .2 NT 44,.4 44 ,.7 45..1 43 .7 45.,4 46..1 41. 6 43 .0 57 .5 67 .6 56 .3 54 .8 54 .3 55 .9 56 .8 55 .1 54 .5 55 .3 57..8 NT 57..2 55..7 55..1 57..0 55..8 56..5 54..7 57.,3 18.6 20.2 18.5 17.9 17.2 18.9 19.2 18.0 17.9 18.4 18.7 NT 18.2 18.2 17.5 18.8 17.9 18.3 17.6 18.5 32..4 29..8 32..8 32..6 31,.7 33 .8 33..8 32..7 32..9 33 .2 32.3 NT 31.8 32.6 31.8 32.9 32.1 32.4 32.1 32.4 ) DuPont-5386 RDW ARET WBC ANEU % xl0^3/uL xl0''3/uL xl0"3/uL 11..9 19.,2 11..6 11..0 11..4 11.,7 11..0 11..3 11..0 12 .4 12 .5 NT 12 .5 12 .6 14 .8 11 .5 11 .4 11 .5 11 .9 12 .1 173 . 725. 171. 122. 161. 206. 145. 119. 150. 220. 7 .40 12..84 10..55 7,.91 7..57 9 .24 10..05 12..36 13..02 12 .67 161. NT 197. 157 . 229. 165. 155. 187. 140. 156. 8 .68 NT 10 .17 11 .50 7 .74 12 .72 12 .43 8 .44 12 .97 9 .89 2 .74 2 .12 2 .05 1..25 2..13 i..99 3 .71 i..80 i..22 4..04 1 .01 NT .73 2..07 1 .66 1..55 3 .41 0,.69 1..49 1..25 Company Sanitized. Does nof con[arn TSCACBI 748 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlOA3/uL ALYM xlOA3/uL Individual Hematology Values AMON AEOS ABAS ALUC ABLT x!0A3/uL xlO~3/uL xlOA3/uL x!0A3/uL xlOA3/uL AMSC xl0A3/uL PLT xlOA3/uL Female, Group: II - 0 mg/kg - Day 93 643354 NT 8 .38 0 .19 0 .40 0..07 0..12 NT NT 1044 643361 NT 9 .60 0 .18 0,.26 0 .10 0,.14 NT NT 1047 643362 NT 5 .97 0 .26 0..11 0..04 0 ,.05 NT NT 1052 643374 NT 5 .55 0..19 0..13 0..06 0..05 NT NT 1320 643398 NT 7 .47 0 .19 0..09 0 .06 0..08 NT NT 967 643406 NT 9 .69 0 .38 0..22 0..09 0.,23 NT NT 1054 643436 NT 7..82 0..19 0..14 0..06 0 .11 NT NT 1129 643463 NT 9 .06 0 .19 0 .,15 0..12 0..13 NT NT 979 643477 NT 9 .14 0 .19 0..18 0..06 0..09 NT NT 787 643486 NT 9 .53 0 .15 0..14 0 ,.09 0..16 NT NT 867 Female, Group: IV - 25 mg/kg - Day 93 643321 NT NT NT NT NT NT NT NT NT 643324 NT 8..15 0..13 0..16 0..12 0 .15 NT NT 958 643364 NT 6..26 0..23 0.,23 0,.03 0 .06 NT NT RNV 643380 NT 5 .91 0..27 0 .14 0 .07 0 .10 NT NT 872 643389 NT 6..63 0..19 0.,06 0..03 0 .09 NT NT 1159 643390 NT 9..85 0..45 0.,14 0 .07 0 .31 NT NT 861 643396 NT 7 .34 0..30 0. 07 0..12 0..15 NT NT 1077 643410 NT 10..54 0 .17 0 ,12 0..08 0 .09 NT NT 1034 643433 NT 6..49 0..16 0 .16 0..04 0 .08 NT NT 1054 643458 NT 9..26 0..23 0. 21 0,.11 0..09 NT NT 1018 ) DuPont-5386 SPEC Company Sanitized. Does not contain TSCA CB! 749 I1 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal ANPR ALYM Number xlO"3/uL xlO~3/uL AMON xlO"3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xlO^/uL xlO~3/uL xlOA3/uL xl0"3/uL AMSC xlOA3/uL PLT xlCT3/uL Female, Group: VI - 100 mg/kg - Day 93 643322 NT 4.28 0.15 0.14 0.05 0.04 NT NT RNV 643323 NT 9.80 0.32 0.40 0.06 0.14 NT NT RNV 643366 643367 NT 7.96 0.22 0.10 0.10 0.12 NT 6.03 0.22 0.23 0.07 0.12 NT NT NT 1083 NT 1134 643392 NT 4.92 0.22 0.20 0.04 0.06 NT NT RNV 643409 NT 6.58 0.23 0.26 0.10 0.08 NT NT 1132 643461 NT 5.72 0.20 0.32 0.04 0.07 NT NT RNV 643462 NT 9.65 0.38 0.18 0.10 0.25 NT NT 1060 643472 NT 11.24 0.24 0.12 0.09 0.11 NT NT 1305 643489 NT 7.71 0.40 0.23 0.09 0.20 NT NT 996 Female, Group: VIII - 250 mg/kg - Day 93 643332 NT 7.35 0.14 0.08 0.05 0.06 NT NT 1045 643340 NT NT NT NT NT NT NT NT NT 643341 NT 7.71 0.35 0.26 0.04 0.08 NT NT 1143 643359 NT 8.24 0.69 0.16 0.05 0.29 NT NT 904 643370 NT 5.56 0.17 0.25 0.02 0.09 NT NT RNV 643404 NT 10.58 0.25 0.16 0.05 0.13 NT NT RNV 643408 NT 8.31 0.32 0.20 0.06 0.12 NT NT 1000 643435 NT 7.23 0.21 0.15 0.03 0.12 NT NT RNV 643446 NT 10.90 0.16 0.16 0.12 0.14 NT NT 849 643466 NT 7.86 0.29 0.24 0.04 0.20 NT NT 1231 ) DuPont-5386 SPEC Company Sanitized. Does not contain TSCA CBI 750 ) ) ri-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlOA6/uL HGB g/dL Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 OK 7.97 14.9 NSR NT NT OK 7.80 14.9 OK 8.33 15.7 OK 7.87 15.2 OK 7.57 14.4 OK 8.00 15.3 OK 7.28 14.0 OK 8.49 15.9 OK 8.25 16.0 Female, Group: VIII - 250 mg/kg -- Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 OK OK OK OK OK CLOT OK OK OK OK 7.91 7.83 8.10 8.58 7.12 NT 8.58 7.38 8.34 8.13 14.6 14.1 15.5 14.9 14.0 NT 15.7 13.5 15.6 15.4 Individual Hematology Values HCT MCV MCH MCHC % fL p g g/dL 45.3 NT 44.6 47.0 48.2 43.6 46.4 42.0 47.9 46.3 44.0 43.0 46.6 44.6 42.2 NT 47.3 39.9 45.3 46.1 56.8 NT 57.2 56.4 61.2 57.7 58.0 57.6 56.5 56.1 55.6 54.9 57.6 52.0 59.2 NT 55.1 54.1 54.3 56.6 18.7 NT 19.2 18.8 19.4 19.1 19.1 19.3 18.7 19.4 18.4 18.0 19.1 17.3 19.6 NT 18.3 18.3 18.8 19.0 33.0 NT 33.5 33.3 31.6 33.0 33.0 33.5 33.1 34.5 33.1 32.7 33.1 33.4 33.2 NT 33.1 33.7 34.5 33.5 DuPont-5386 RDW AKET WBC ANEU % xlOA3/uL xlOA3/uL xlOA3/uL 13.3 NT 12.6 12.6 12.5 12.8 12.3 12.8 11.3 11.2 11.5 11.8 11.8 11.9 11.7 NT 12.0 11.8 11.9 11.0 157. NT 206. 174. 179. 162. 205. 178. 133 . 148 . 7.17 NT 6.44 6.91 10.41 7.69 7.19 6.53 8.04 11.41 106. 145 . 159. 149. 235. NT 152. 120. 130. 110 . 6.94 8.55 8.95 6.44 11.22 NT 8.02 8.59 7.70 6.63 1.08 NT 1.31 0.70 0.84 1.61 1.34 1.04 1.11 1.10 1.50 1.07 1.55 0.90 1.31 NT 2.48 2.24 1.95 1.25 Company Sanitized. Does notcontain TSCA CBI 751 ri-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlO|A3/uL ALYM xlOA3/uL ANON xlO'-3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xlO~3/uL xlOA3/uL xlQ-3/uL xl(T3/uL, AMSC xlO~3/uL PLT xlO"3/uL Female, Group: II - 0 mg/kg - Day 125 643330 NT 5.80 0.12 0.09 0.01 0.06 NT NT 958 643336 NT NT NT NT NT NT NT NT NT 643377 NT 4.62 0.20 0.12 0.06 0.13 NT NT 985 643387 NT 5.88 0.14 0.06 0.03 0.08 NT NT 1376 643405 NT 9.04 0.30 0.07 0.02 0.14 NT NT 1158 643415 NT 5.55 0.27 0.16 0.04 0.06 NT NT 1256 643425 NT 5.45 0.15 0.10 0.07 0.09 NT NT 797 643426 NT 5.07 0.25 0.05 0.03 0.08 NT NT 1050 643448 NT 6.52 0.17 0.06 0.10 0.08 NT NT 1128 643453 NT 9.72 0.31 0.16 0.04 0.09 NT NT 682 Female, Group: VIII ~ 250 mg/kg - Day 125 643345 NT 4.95 0.20 0 .10 0 .05 0 .13 NT NT 1212 643347 NT 7.08 0.16 0 .11 0 .06 0 .07 NT NT 1431 643351 NT 6.95 0.14 0..21 0 .03 0 .08 NT NT RNV 643358 NT 4.94 0.26 0 .14 0 .02 0 .18 NT NT RNV 643423 NT 9.16 0.43 0..16 0 .03 0 .12 NT NT RNV 643441 NT NT NT NT NT NT NT NT NT 643444 NT 4.58 0.58 0..17 0 .02 0 .19 NT NT 1088 643456 NT 5.72 0.30 0..16 0 .07 0..09 NT NT 1034 643474 NT 5.24 0.27 0..15 0 .03 0 .08 NT NT RNV 643481 NT 4.88 0.23 0..17 0..01 0 .09 NT NT 1095 DuPont-5386 SPEC Com pany Sanitized. Does not contain t s c a H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - Q mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 23 11 11 11 12 14 13 13 11 12 13 11 11 11 12 13 13 13 12 12 ACAN 1 1 1 2 2 3 2 2 1 1 1 1 2 1 2 2 2 2 1 2 TARG DuPont-5386 RX HJB Company Sanitized, Does nof c n ta ln T S C A C B I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 -- 11 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 11 11 12 14 11 1 11 12 11 12 12 13 11 11 12 12 11 12 11 13 ACAN 1 1 2 3 1 1 1 2 2 1 3 2 1 3 2 2 2 1 2 2 TARG DuPont-5386 RX HJB Company Sanitized. Does not contain T S C A CBI I ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Individual Red Blood Cell Morphology Values i DuPont-5386 com pany Sanitized. Does no! contain T S C A CBI 755 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 1-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 Individual Red Blood Cell Morphology Values DuPont-5386 Company Sanitized. Does not contain T S C A CB ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 91 643143 643150 -- __ 643185 -- __ __ 643189 -- 11 643204 -- -- 643205 -- 3 2 1 643235 643241 643288 - __ 1 -- __ -_ 643300 -- -- -- 1 1_ _ 3 2 _ 1 __ 1 __ 3 3 23 13 13 13 1-3 Male, Group: III - 25 mg/kg - Day 91 643173 1 643179 -- -- -- 1 643180 -- -- 1 643228 -- -- -- -- 1 -- 643240 -- __ -- 1 __ 643264 -- -- -- 2 643272 -- -- __ _ 643290 -- -- -- -- 1 643292 -- -- -- -- 1 643308 -- __ __ 1-- 3 1 3 3 3 3 3 3 2 ACAN 3 1 3 3 4 3 3 3 2 1 1 2 3 2 3 __ 3 3 3 TARG _ _ _ __ _ _ _ _ __ __ __ __ _ _ _ __ DuPont-5386 RX HJB __ __ __ __ __ -- _ _ _ _ __ -- Company Sanitized. Does not contain TS CA CBI 757 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 __ __ 643247 -- -- 643250 643257 -- __ 643275 643311 -- -- 643314 -- 643318 -- -- Male, Group: VII - 250 mg/kg - Day 91 643174 2 643193 643194 -__- -2 643201 -- 1 643215 -- -- 643252 -- 2 643259 643260 --- 2 643298 1 643315 -- -- __ _ __ __ __ 1 1 __1 2 1 I -- _ _ __ __ __ _ _ -- 1 1 __ I - i i i i i i i i i 2 1 2 1 1 2 2 1 1 2 3 3 1 2 3 1 3 3 3 3 2 3 2 2 3 2 3 2 3 ACAN 3 3 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 TARG DuPont-5386 RX HJB ampany Sanitized. Does not contain T S C A CB1 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 1-POIKILOCYTOSIS 1-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE Male, Group: III.- 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 1-POIKILOCYTOSIS Individual Red Blood Cell Morphology Values ) DuPont-5386 Company Sanitized. Does notcontainT S C A CBt 759 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 1-POIKILOCYTOSIS Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 1-POIKILOCYTOSIS 1-POIKILOCYTOSIS 1-POIKILOCYTOSIS Individual Red Blood Cell Morphology Values I DuPont-5386 Company Sanitized. Does not contain T S C A CBI 760 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 125 643162 __ __ 643172 -- i 643195 643226 -- -- -i 643237 -- i 643246 -- i 643253 -- i 643262 643303 -- -- -i 643304 -- -- _ i : 1 1 1 1 -- Male, Group: VII - 250 mg/kg - Day 125 643151 643165 _ __ _ 643220 -- 1 643225 -- 1 643234 -- 643236 -- 2 643258 -- 1 643266 -- 1 643296 -- 1 643316 -- 1 __ __ 1 __1 1 1 1- 1 __ __ __ -__ __ __ __ -- _ _ __ i -- 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 2 2 ACAN 1 2 1 1 1 3 1 1 1 1 3 1 3 1 3 1 2 TARG DuPont-5386 RX HJB Company Sanitized. Does not contain T S C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ Animal Number SPEC Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 1-SPHEROCYTE Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 1-POIKILOCYTOSIS Individual Red Blood Cell Morphology Values I DuPont-5386 C o m p a q S a w ,/* ,. Dm s no( conia(n t s m c b | 762 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 11 11 11 14 11 13 12 13 12 11 12 12 13 12 11 14 11 12 11 ACAN 1 1 2 2 1 2 2 1 1 2 2 1 2 1 1 TARG DuPont-5386 RX HJB Company Sanitized Does not contain T S C A CBI ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 ------- -- ---- -- --- --- --- --- --- --- --- --- -- -- -- Female, Group: VIII - 250 mg/kg - Day 45 643332 -- -- -- 643340 -- -- -- 643341 -- -- -- 643359 -- -- -- 643370 -- -- -- 643404 - - - - -- 643408 -- -- -- 643435 - - -- -- 643446 -- -- -- 643466 -- - - - - -- -- ------__ -- --- -- __ __ __ 1 1 1 1 1 1 1 1 1 1 1 i i i i i i i x i 3 2 1 2 2 4 3 3 2 3 1 2 3 2 3 3 3 3 4 3 ACAN 1 1 2 2 2 2 1 2 1 1 1 2 1 2 3 1 2 1 TARG ) DuPont-5386 RX Company Sanitized. Does not confain TSC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Numfoer SPEC Female, Group: II - 0 mg/kg - Day 45 643354 643362 643361 643374 643398 643406 643436 643463 643477 643486 2-HEMOGLOBIN CRYSTAL Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 1-HEMOGLOBIN CRYSTAL Individual Red Blood Cell Morphology Values DuPont-5386 Company Sanitized. Does not contain T S C A CBI 1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 2-HEMOGLOBIN CRYSTAL 1-HEMOGLOBIN CRYSTAL 2-HEMOGLOBIN CRYSTAL Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 1-HEMOGLOBIN CRYSTAL ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI 766 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 1 1 1 1 1 1 1 1 1 1 11 12 11 11 11 11 11 12 1 ACAN 1 2 1 TARG DuPont-5386 RX HJB Company Sanitized. Does no! contain T S C A H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 11 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 1 -- -- 2-- 2 1 -- 1 1 -- 3 13 1 1 -- __ 2 2 --1 - - 1 1 2 1 -- 2 1-- 1 ___ 1-- 1 -1 -1 -1 -1-- 1 -- 1 2 2 2 3 3 4 2 3 ACAN -- 1 -- 1 1 2 1 -- 1 2 -- 3 1 2 1 1 2 1 3 TARG -- __ ---- __ ---- DuPont-5386 RX HJB -- __ --- -- --- --- --- --- -_ _ -- Company Sanitized. Does not contain T S C A CB1 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 1-POIKILOCYTOSIS Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 Individual Red Blood Cell Morphology Values I DuPont-5386 Company Sanitized. Does nolconlain TSCACBI 769 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 1-SPHEROCYTE DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 11 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 1i 12 11 11 12 12 11 11 1 1 1 1 2 11 12 1 11 11 1 ACAN 2 2 1 1 TARG DuPont-5386 company Sanitized. Does not contain T S C A CBI 771 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 ) DuPont-5386 Com pany Sanitized. Does not contain T S C A GBI 772 I)) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive E v a l u a t i o n s __________________________________ DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL 1 -- -- -- -1 -- -- -- -- SPEC DECR PLATELET ADEQ PLATELET Company Sanitized. Does not contain T S C A CBI 773 ! 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NORMAL NORMAL -- -- NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL __ _ _ _ _ __ -- 1 1 __ -- _ _ __ _ __ _ _ __ -- -- __ _ -- -- __ __ __ _ -- -- -- -- __ -- -- -- -- -- -- -- -- -- -- -- Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NORMAL NORMAL NORMAL NORMA_L_ NORMAL NORMAL NORMAL NORMAL -- 1 __ __ __ _ -- -- -- -- __ -- -- -- __ __ -- -- __ _ -- 1 -- __ -- -- -- __ __ __ -- -- __ __ _ -- _ _ -- -- __ __ SPEC UTD PLATELET DECK PLATELET DECR PLATELET UTD PLATELET Company Sanitized. Does not contain T S C A CBI 774 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: I - 0 mg/kg - Day 91 643143 643150 NORMAL NORMAL --- __ __ __ __ _ __ _ __ _ 643185 643189 643204 643205 643235 -- NORMAL NORMAL NORMAL NORMAL --- __ __ __ _ -__ _ _ __ __ __ _- _ _ __ __ _ _ _ _ 643241 -- -- -- 1 __ __ __ 643288 NORMAL -- -- -- __ __ __ __ 643300 1 Male, Group: III - 25 mg/kg - Day 91 643173 NORMAL _ _ _ _ _ _ _ 643179 NORMAL -- -- -- -- 643180 NORMAL -- __ . -- -- -- -- 643228 NORMAL -- -- -- -- -- -- -- 643240 NORMAL -- -- -- -- -- -- -- 643264 NORMAL -- __ -- -- __ -- 643272 -- -- -- -- -- -- -- 643290 NORMAL -- -- -- -- -- -- -- 643292 NORMAL -- -- -- __ -- -- 643308 NORMAL -- __ -- __ -- -- SPEC UTD PLATELET DECR PLATELET Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Naie, Group: V - 100 mg/kg - Day 91. 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL 1-- -- -- -- 1 1 1 SPEC DECR PLATELET DECR PLATELET UTD PLATELET DECR PLATELET Com pany Sanitized. Does not contain T S C A CBI 776 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC BP TOX VC Male, Group: 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 I - 0 mg/kg NORMAL NORMAL NORMA- L- NORMAL NORMAL NORMAL NORMA- L- -- - Day 125 __ __ __ ____ _____ __ -- __ __ ___ ______ -- Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL __ __ __ _ _ -- __ ____ __ ______ __ ____ 1 _____ 1 1 ____ 1 SPEC DuPont-5386 ADEQ PLATELET UTD PLATELET DECR PLATELET ADEQ PLATELET Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group: II - 0 mg/kg - Day 45 643354 NORMAL -- -- -- -- -- _ _ 643361 NORMAL -- __ -- -- __ 643362 NORMAL _ _ -- -- -- -- -- 643374 NORMAL -- -- -- -- -- -- 643398 NORMAL -- -- -- -- -- 643406 -- -- 1 -- -- -- 643436 NORMAL --- __ -- -- _ _ 643463 -- -- -- 1 -- -- -- 643477 -- 1 -- -- - - 643486 - -- 1 -- -- -- Female, Group : IV - 25 mg/kg - Day 45 643321 __ __ __ __ __ 643324 NORMAL __ __ -- _ _ 643364 NORMAL -- -- -- 643380 NORMAL -- __ - -- 643389 NORMAL -- -- __ _ _ -- - 643390 NORMAL -- -- -- -- -- -- -- 643396 NORMAL -- __ -- -- 643410 NORMAL -- -- __ -- -- -- 643433 NORMAL -- -- _ _ -- -- -- 643458 NORMAL -- _ _ -- -- SPEC ADEQ PLATELET UTD PLATELET DECR PLATELET ADEQ PLATELET Company Sanitized. Does not contain T S C A CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX Female, Group : VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NORMAL NORMAL NORMAL NORMAL NORMA-L- -- NORMAL NORMAL NORMAL __ __ __ _ __ _ _ __ __ __ _ _ ___ __ __ i __i _ __ _ _ __ _ __ __ _ __ ___ Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NORMAL NORMAL __ NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL __ -- __ __ __ __ __ -- _ _ __ __ 1 ___ __ _ _ __ _ __ _ _ _ __ __ _ __ SPEC DuPont-5386 ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET Company Sanitized. Does not contain T S C A CBI 779 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group : II - 0 mg/kg - Day 93 643354 NORMAL _ _ _ 643361 643362 643374 643398 643406 NORMAL NORMAL NORMAL NORMAL NORMAL -__ __ --- __ -__ --- -__ __ __ _ _ _ _ _ 643436 643463 643477 NORMAL NORMAL NORMAL -- __ __ _ __ _ __ __ _ 643486 NORMAL Female, Group : IV - 25' mg/kg - Day 93 643321 643324 643364 643380 643389 _ NORMA-L- NORMAL NORMAL _ __ -__ -- __ __ -- _ __1 _ _ _ _ _ 643390 643396 643410 643433 643458 NORMAL NORMAL NORMAL NORMAL NORMAL -__ __ -- _ __ __ _ _ _ _ _ _ _ _ SPEC DuPont-5386 UTD PLATELET Company Sanitized. Does not contain T S C A CBI 780 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NORMAL NORMAL NORMAL -- NORMAL NORMAL NORMAL ----- -__ -- -- -- --- ------- __ Female, Group: VIII - 250 mg/kg - Day 93 643332 NORMAL -- -- 643340 -- __ -- 643341 NORMAL -- -- 643359 643370 643404 NORMAL -- -- --- -- -- 643408 643435 NORMA--L -- -- -- -- 643446 NORMAL -- -- 643466 NORMAL -- -- 1 1 --- 1 -- 1 --- -- 1 1 -- 1 --- DuPont-5386 SPEC UTD PLATELET UTD PLATELET UTD PLATELET UTD PLATELET UTD PLATELET ADEQ PLATELET UTD PLATELET Company Sanitized. Does not contain T S C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 NORMA--L NORMAL NORMAL __ -- __ -- __ -- -- __ -- -- __ __ __ --- --- -- __ -- ---- 643405 NORMAL -- -- -- -- -- -- -- 643415 NORMAL -- __ __ -- __ -- 643425 643426 643448 643453 NORMAL NORMAL NORMAL NORMAL _-_---- -- ---- -- -- -- --- -- -- -- -- ---- -- -- -- --- 'emale, Group : VIII - 250 mg/kg - Day 125 643345 NORMAL __ __ _ __ _ __ __ 643347 643351 NORMAL -- -- -- --- -- -- 1-- -- -- --- __ -- 643358 -- -- -- 1 __ -- -- 643423 643441 643444 643456 NORMAL; NORMAL -- --- -- --- -- __1 -- -- -- --- - -- -- --- - -- --- ---- -- --- - -- 643474 643481 -- NORMAL __- - - -- __1 - - -- -- -_-_ -- -- SPEC DECK PLATELET DECK PLATELET UTD PLATELET UTD PLATELET Company Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM FLIP PICT Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III ~ 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation PT APTT sec sec 14.7 15.6 15.2 16.2 15.7 14.4 14.6 15.1 14.3 16.5 14.8 14.5 15.2 14.3 14.6 14.8 14.5 15.3 14.5 14.1 17.5 17.9 16.8 21.9 18.0 15.0 20.2 22.7 16.5 20.0 13.6 13.1 19.4 17.0 18.4 15.7 16.3 18.7 14.3 16.1 DuPont-5386 Company Similized. Does nolconlaii, TSCA CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM FLIP PICT Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation FT APTT sec sec NT 14.7 14.3 14.7 16.6 15.2 16.5 15.5 15.0 14.1 15.6 15.2 14.7 15.0 16.7 15.8 15.5 16.4 14.9 14.9 NT 14.5 13.5 15.7 18.7 13.2 18.7 15.7 17.5 14.8 18.6 17.3 16.1 17.0 16.4 17.4 16.2 16.2 16.0 16.4 784 Values DuPont-5386 Com pany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM FLIP PICT Ferna1e , Group : II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE SMALL NONE NONE NONE NONE TRACE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE TRACE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 14.7 NT 14.2 13.4 14.8 14.9 13.9 13.7 15.0 16.0 NT 14.2 14.3 14.3 14.7 14.0 14.0 14.4 14.7 14.8 17.9 NT 16.6 15.0 17.8 16.5 15.9 16.3 18.2 19.6 NT 16.6 15.9 12.9 15.9 17.1 17.7 15.3 14.8 16.3 DuPont-5386 Com pany Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE TRACE NONE NONE NONE NONE Individual Coagulation PT APTT sec sec 13.8 14.4 14.1 14.7 14.6 15.3 14.4 15.2 13.6 14.5 13.7 NT 13.9 14.1 13.4 14.0 13.6 14.6 15.0 14.6 13.8 17.3 17.3 17.1 14.4 15.9 14.3 14.3 17.1 12.9 14.7 NT 15.3 16.2 14.6 14.1 16.7 13.7 12.8 17.5 786 I DuPont-5386 Company Sanitized. Does not contain T S C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEW SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 TRACE SMALL NONE NONE NONE SMALL TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 97 84 82 79 69 70 66 71 74 90 72 81 71 104 79 94 90 74 70 100 37 33 28 27 30 31 23 30 28 31 40 31 33 24 32 26 36 35 38 34 787 ) DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BIL1 mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 13.3 19.4 17.3 26.0 20.3 15.6 15.4 25.0 15.6 20.0 21.1 16.2 14.3 20.6 12.3 11.9 17.6 27.4 18.4 18.9 128 <0.10 184 0.10 113 <0.10 144 <0.10 87 0.12 123 0.11 153 0.10 157 0.12 91 <0.10 158 0.13 144 <0.10 165 0.11 109 <0.10 104 0.15 125 <0.10 100 0.10 176 <0.10 204 0.12 175 <0.10 139 0.15 15 0.34 13 0.33 14 0.38 16 0.29 13 0.34 12 0.27 15 0.34 12 0.43 17 0.29 14 0.36 12 0 .24 16 0 .26 15 0 .29 15 0 .32 15 0..31 12 0..36 16 0..35 14 0 .40 14 0..29 12 0..28 56 74 85 72 71 107 134 82 80 77 70 56 71 80 64 52 47 76 69 67 Company Sanitized. Does not contain T S C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L .e, Group:: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 MODERATE TRACE MODERATE NONE TRACE NONE SMALL TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE TRACE MODERATE NONE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NT-HEMOL 80 NT-HEMOL 85 75 80 65 76 67 76 74 99 78 NT-HEMOL 86 86 104 63 64 88 NT-HEMOL 32 NT-HEMOL 16 33 35 29 26 24 31 31 31 46 NT-HEMOL 23 35 46 27 26 32 788  DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 15.,7 14..3 20 ,.9 18..2 22..9 16,.9 17..5 17..5 16..9 21..0 NT-HEMOL 141 NT-HEMOL 134 157 141 202 153 162 159 NT-HEMOL <0..10 NT-HEMOL <0..10 <0..10 0..12 <0..10 0..12 0..12 <0..10 28..4 11..6 20..8 6..2 16..1 20,.1 20,.9 13..9 14 .0 22 .1 187 185 225 NT-HEMOL 191 157 240 166 165 152 0..10 <0..10 <0..10 NT-HEMOL <0..10 <0.,10 <0..10 <0..10 <0..10 <0..10 14 0 .33 15 0 .29 16 0 ,.27 19 0..30 13 0..27 17 0..36 14 0..26 14 0..31 14 0,.33 15 0,.24 14 0 .45 17 0 .36 14 0..42 16 0..28 13 0..30 12 0 ,.36 13 0..29 13 0 .25 14 0..39 13 0 .31 62 39 61 72 22 65 45 54 61 76 91 64 39 67 52 28 48 55 55 36 Com pany Sanitized. Does not contain T S C A CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations 1 DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day .44 643143 65 104 6.4 3.9 2.5 10.2 8.8 143.3 643150 78 93 6.0 3.9 2.1 10.4 8.2 144.3 643185 41 111 6.5 4.1 2.4 10.5 8.2 147.0 643189 113 145 6.4 4.0 2.4 10.9 9.4 145.9 643204 177 106 6.6 4.3 2.3 11.0 8.4 141.7 643205 41 97 6.8 4.2 2.6 10.8 8.4 144.4 643235 89 109 6.5 4.0 2.5 10.8 7.9 142.1 643241 217 99 6.9 4.4 2.5 11.5 9.1 147.7 643288 79 105 6.7 4.0 2.7 10.8 7.7 143.8 643300 65 135 6.7 4.4 2.3 11.0 10.0 144.5 Male, Group: III - 25 mg/kg - Day 44 643173 126 96 6.5 4.3 2.2 11.2 9.0 144.6 643179 81 96 6.4 4.0 2.4 10.5 9.6 145.2 643180 124 120 6.4 3.9 2.5 11.1 9.2 141.7 643228 122 129 6.6 4.1 2.5 11.1 9.6 143.3 643240 56 89 6.1 4.0 2.1 10.4 8.9 143.7 643264 56 101 6.8 4.2 2.6 10.4 8.1 143.7 643272 46 96 6.7 4.3 2.4 10.5 9.2 143.7 643290 101 98 7.1 4.6 2.5 11.2 9.3 142.4 643292 97 107 6.8 4.5 2.3 11.6 9.1 144.1 643308 94 109 6.5 4.2 2.3 10.6 8.6 143.0 K mmol/L 6.30 6.55 6.43 5.65 5.95 6.15 5.34 6.16 5.54 6.13 5.82 6.45 5.88 6.29 5.86 5.89 6.31 5.97 5.88 6.15 CL mmol/L 101.7 101.5 103.6 101.6 98.2 98.9 98.0 99.7 101.2 100.4 95.6 101.8 99.3 98.6 101.9 101.9 100.5 97.6 97.6 99.2 SPEC Company Sanitized Does not contain T S C A C B i )) H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations I DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT-HEMOL 35 NT-HEMOL 122 28 65 52 86 85 130 104 NT-HEMOL 110 6.1 123 NT-HEMOL 112 6.6 88 6.5 109 7.2 126 6.8 103 6.8 103 6.7 106 7.0 Male, Group : VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 152 39 42 NT-HEMOL 57 16 35 55 47 37 147 7.8 103 7.6 95 7.5 107 NT-HEMOL 101 6.8 116 6.9 107 7.4 106 7.1 106 7.6 133 6.7 NT-HEMOL 4.1 NT-HEMOL 3.2 4.4 4.6 4.5 4.3 4.4 4.6 5.1 5.2 5.2 NT-HEMOL 4.7 4.8 5.1 4.9 5.2 4.5 NT-HEMOL 2.0 NT-HEMOL 3.4 2.1 2.6 2.3 2.5 2.3 2.4 2.7 2.4 2.3 NT-HEMOL 2.1 2.1 2.3 2.2 2.4 2.2 10.7 9.9 11.2 11.1 10.4 11.5 11.1 10.7 10.9 10.9 NT-HEMOL 9.0 NT-HEMOL 10.4 8.8 9.5 10.9 9.5 9.0 9.0 142.4 145.0 144.3 144.9 144.5 145.0 144.2 145.6 144.2 143.6 11,,6 11,,1 11,.4 11,.1 10,.7 11..2 11..0 11..1 11..4 11 ..4 10.3 9.2 9.5 NT-HEMOL 8.3 10.2 8.4 9.2 8.5 11.0 144 .5 145..7 143 .8 144..9 143,.1 141..6 143..8 143 .7 145..1 143 .2 K mmol/L RNV 6.47 RNV 5.65 5.92 6.19 6.95 6.52 6.14 6.11 6.09 5.43 5.78 RNV 6.06 6.89 6.26 6.08 5.90 5.30 CL mmol/L 97.6 104.8 99.3 99.3 98.8 96.8 99.5 102.0 98.9 98.4 98 .3 99..8 96..1 100.,4 100..1 97..6 100..2 101..5 99 ..5 99 ..9 Company Sanitized. Does nol contain TSCA CBI 790 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number SHEM SLIP Individual Serum and Plasma Chemistry Values SICT AST IU/L ALT IU/L SDH IU/L ALKP IU/L Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 SMALL TRACE NONE NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 87 99 110 74 86 166 80 93 66 126 121 84 62 79 93 74 109 95 73 82 33 20.5 37 32.2 55 35.5 28 30.6 34 26.4 44 35.8 30 28.4 35 40.6 31 22.4 36 13.8 48 32.6 42 23.4 26 14.1 22 21.3 40 18.7 28 22.5 41 33.6 38 18.7 38 21.2 40 27.2 81 131 91 103 66 84 116 116 71 111 90 95 76 67 93 81 109 138 104 98 BILI mg/dL <0.10 <0.10 <0.10 <0.10 <0.10 <0.10 <0.10 0.12 <0.10 0.14 0.11 <0.10 <0.10 <0.10 <0.10 0.10 <0.10 <0.10 <0.10 <0.10 BUN mg/dL 16 15 13 14 14 13 19 15 18 17 14 14 14 16 16 12 19 19 14 14 CREA mg/dL 0.43 0.39 0.42 0.42 0.50 0.37 0.45 0.55 0.35 0.34 0.47 0.30 0.38 0.27 0.39 0.42 0.55 0.49 0.35 0.36 CHOL mg/dL 45 64 74 73 72 99 146 70 67 74 70 55 67 84 60 49 46 80 76 63 Company Sanitized. Does not contain T S C 51  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR NONE TRACE SMALL SMALL NONE SMALL SMALL NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NT 64 71 80 104 103 76 79 63 77 97 85 174 98 81 85 110 81 71 73 NT 29 37 30 32 44 30 37 26 31 26 32 92 23 31 48 71 44 33 30 792 I DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL NT 16.5 28.8 18.8 13.9 26.7 26.6 29.8 21.9 27.2 16..3 24..1 28..1 13..7 25..0 39 .2 41..9 28 .3 19..7 21 .6 NT NT 161 <0.10 174 <0.10 125 <0.10 112 <0.10 129 <0.10 136 <0.10 154 <0.10 135 <0.10 126 <0.10 201 <0..10 183 <0..10 174 <0..10 162 <0..10 230 <0..10 166 <0 .10 243 <0 .10 192 <0..10 176 <0 .10 135 <0..10 NT NT 15 0.35 17 0.40 15 0.31 16 0.40 18 0.49 13 0.37 17 0.43 15 0.38 14 0.42 13 0 ,.42 15 0..49 17 0,.44 17 0..41 17 0..38 15 0..47 15 0,.58 16 0..41 14 0..37 15 0..50 NT 37 71 37 23 67 39 49 54 55 82 44 33 54 58 34 34 46 38 42 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day 91 643143 67 131 6.5 3.9 2.6 10.5 8.6 145.2 643150 99 80 6.1 4.0 2.1 10.1 8.1 147.7 643185 84 196 6.8 4.2 2.6 11.7 12.0 150.8 643189 200 110 6.8 4.4 2.4 10.7 7.4 146.1 643204 121 179 6.9 4.4 2.5 11.8 12.9 149.3 643205 52 90 6.7 4.0 2.7 10.5 7.8 147.2 643235 160 106 7.4 4.5 2.9 11.2 7.5 147.1 643241 145 151 7.6 4.7 2.9 12.0 11.7 149.3 643288 191 109 7.0 4.3 2.7 10.9 6.9 146.5 643300 153 102 6.8 4.3 2.5 10.2 8.6 143.0 Male, Group: III - 25 mg/kg - Day 91 643173 91 96 7.3 4.7 2.6 10.7 7.4 146.2 643179 97 87 6.2 4.2 2.0 9.9 7.9 147.0 643180 107 93 6.7 4.0 2.7 10.6 8.6 144.1 643228 161 105 6.6 4.3 2.3 10.5 7.9 144.7 643240 58 74 6.7 4.4 2.3 10.2 8.0 145.2 643264 127 104 6.8 4.4 2.4 10.8 7.8 147.3 643272 39 123 7.1 4.5 2.6 11.2 12.4 148.5 643290 76 117 7.2 4.6 2.6 10.8 10.0 145.1 643292 74 108 6.7 4.4 2.3 10.7 8.5 144.9 643308 149 109 6.7 4.4 2.3 10.8 8.2 145.8 K mmol/L 6.36 6.89 7.35 5.54 6.52 6.10 6.01 6.88 5.43 6.25 6.25 6.08 6.54 5.85 5.66 5.38 6.64 6.07 6.49 5.69 CL mmol/L 100.7 101.9 103.6 100.1 103.2 98.9 99.4 100.3 98.9 100.0 97.5 102.6 99.4 99.3 101.9 99.2 102.2 100.3 100.5 97.6 PHEM NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE .ompany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L H O o Male, Group: V - mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NT NT NT NT NT NT NT 38 103 6.8 4.7 2.1 10.2 7.7 147.5 73 102 7.6 4.8 2.8 10.9 8.6 147.4 36 87 6.7 4.3 2.4 9.9 8.8 143.9 23 80 6.5 4.4 2.1 9.9 8.3 144.5 73 132 7.5 4.8 2.7 11.3 9.7 146.4 24 113 7.2 4.8 2.4 10.3 9.6 148.0 27 164 7.4 4.8 2.6 11.3 10.8 145.3 63 96 7.4 5.1 2.3 10.5 8.1 146.8 81 133 6.8 4.7 2.1 10.6 8.9 144.8 Male, Group: VTI - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 98 116 8.1 5.6 2.5 11.1 8.7 144.9 37 89 7.8 5.5 2.3 10.7 8.2 146.2 20 143 7.4 5.1 2.3 10.4 9.4 140.6 75 93 7.7 5.4 2.3 10.9 7.9 145.5 39 95 7.5 5.3 2.2 10.5 8.0 145.0 10 138 7.6 5.3 2.3 11.5 10.6 145.0 34 162 8.3 6.0 2.3 11.9 12.2 148.2 19 149 7.3 5.1 2.2 11.0 9.8 144.1 36 90 7.8 5.3 2.5 11.0 7.9 146.6 22 83 7.0 4.9 2.1 10.3 8.0 145.7 K mmol/L NT 5.79 6.13 6.25 6.24 6.09 6.85 6.89 6.04 5.86 6.16 5.73 6.80 6.66 6.50 7.13 6.19 6.32 5.27 5.75 CL mmol/L NT 101.8 99.7 100.3 101.3 101.0 102.1 100.6 98.1 99.5 100.3 97.3 98.6 99.0 98.1 98.2 101.9 99.0 99.2 97.8 PHEM NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE Company Sanitized. Does not contain T S C A CBI 794 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU pg/mL Male, Group: 1 - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU pg/mL, Male, Group: V - 100 mg/kg - D a y 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR 0.3 0.4 0.6 0.4 0.5 0.3 0.3 0.6 0.4 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.7 0.6 0.7 0.6 0.9 0.5 0.6 0.6 0.7 0.7 DuPont-5386 Company Sanitized. Does not contain T S C A CBI !I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 125 643162 NONE NONE NONE 84 43 643172 NONE NONE NONE 68 28 643195 NONE NONE NONE 78 39 643226 TRACE NONE NONE 93 40 643237 NONE NONE NONE 71 22 643246 NONE NONE NONE 77 29 643253 TRACE NONE NONE 78 30 643262 TRACE NONE NONE 71 31 643303 NONE NONE NONE 81 38 643304 NONE NONE NONE 77 27 Male, Group: VII - 250 mg/kg - Day 125 643151 NONE NONE NONE 62 27 643165 NONE NONE NONE 91 74 643220 TRACE NONE NONE 77 33 643225 SMALL NONE NONE 93 34 643234 NONE NONE NONE 70 36 643236 NONE NONE NONE 76 31 643258 NONE NONE NONE 67 33 643266 NONE NONE NONE 84 29 643296 NONE NONE NONE 88 26 643316 NONE NONE NONE 78 41 797 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 11.,4 16..8 21..5 25..3 20..1 33 .7 17 .0 17 .1 25 .1 27..3 12..0 17 .7 15 .5 9,.9 10..5 13 .5 16..8 9..3 15..9 18 .5 108 <0 .10 71 <0 .10 85 <0 .10 48 0 .11 73 <0..10 68 0..10 96 <0..10 85 <0..10 101 <0 .10 72 <0 .10 92 <0..10 96 <0..10 75 <0,.10 59 <0..10 60 <0..10 71 <0..10 95 <0.,10 75 <0..10 62 <0..10 81 <0 .10 15 0..30 15 0 ,.37 13 0..40 16 0..46 15 0,.51 17 0..36 17 0..43 14 0..39 16 0..40 13 0 .34 19 0 .42 19 0 .35 19 0 .41 20 0..41 14 0..36 18 0..41 19 0 .42 17 0 .32 18 0 .52 16 0 .34 56 76 70 55 76 91 75 88 73 89 58 63 50 71 44 72 58 52 44 50 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day 125 643162 41 92 6.9 4.2 2.7 10.4 7.4 146.2 643172 122 118 7.4 4.4 3.0 10.4 6.8 146.4 643195 124 103 6.6 4.4 2.2 10.2 6.7 146.5 643226 56 201 6.7 4.1 2.6 10.8 8.5 146.2 643237 64 113 6.5 4.2 2.3 10.7 7.9 146.6 643246 167 111 6.9 4.3 2.6 10.6 9.1 148.1 643253 91 102 7.3 4.4 2.9 10.7 7.8 146.3 643262 102 104 6.8 4.3 2.5 10.4 7.8 145.3 643303 98 180 7.5 4.6 2.9 11.2 11.6 146.9 643304 81 146 7.0 4.8 2.2 10.9 7.0 145.3 -e, Group: VII - 250 mg/kg - Day 125 643151 28 88 6.6 4.5 2.1 9.9 7.6 146.9 643165 66 99 6.5 4.4 2.1 9.9 7.7 147.3 643220 29 97 6.4 4.1 2.3 10.0 7.5 149.7 643225 58 102 7.0 4.5 2.5 10.1 7.6 145.5 643234 45 95 6.6 4.1 2.5 10.3 7.5 146.5 643236 57 106 7.2 4.3 2.9 10.4 7.4 146.4 643258 32 101 7.0 4.6 2.4 10.3 7.2 146.1 643266 43 119 6.4 3.9 2.5 9.9 8.3 143.7 643296 39 146 6.7 4.3 2.4 10.8 10.0 146.8 643316 154 107 7.0 4.7 2.3 10.2 7.4 146.9 K mmol/L 5.70 6.00 6.22 5.59 7.07 7.07 6.71 7.35 6.60 5.81 5.67 5.75 5.90 6.78 5.71 6.18 5.84 5.98 6.76 5.96 CL mmol/L 104.7 102.8 103.6 103.6 103.4 103.8 101.6 103.5 104.5 102.7 102.1 104.7 105.4 102.3 102.5 103.0 101.2 105.2 102.2 105.2 PHEM NONE TRACE NONE NONE NONE NONE NONE NT TRACE NONE NONE TRACE NONE NONE TRACE NT NONE NONE NONE NONE Com pany Sanitized. Does not contain T S C A CBI 798 iI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________ Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU ug/mL SPEC Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 NONE TRACE NONE NONE NONE NONE NONE NT NONE TRACE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 TRACE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE 0.2 0.2 0.1 0.1 QNS 0.2 0.1 0.1 0.1 0.1 Accidental spillage of serum I DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT iu/L Female, Group: II - 0 mg/kg - Day 45 543354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE TRACE NONE NONE NONE NONE NONE SMALL NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE 95 69 99 92 84 76 73 73 101 107 NT 60 73 73 106 73 59 93 65 82 36 28 44 45 37 39 33 33 46 33 NT 22 42 31 23 35 32 27 37 34 DuPont-5386 Chemistry Values SDH IU/L AL KP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 13..9 15,.2 15,.1 26..8 14 ,.7 18..9 14..4 21,.1 28 .1 13 .6 NT 12.8 13.5 19.3 20.9 27.4 20.5 19.6 17.3 13.7 98 0..10 45 0 .14 80 0 ,14 67 0..15 64 0 ,.12 56 0 .17 37 <0 .10 60 0 .13 67 0 ,.13 81 0..17 NT NT 86 0 .15 52 <0 .10 61 0 .11 108 <0 .10 98 0 .13 56 0 .13 46 <0 .10 54 0 .15 74 0 .15 16 0..40 14 0..36 16 0..37 18 0 .43 15 0..36 17 0..48 15 0 ,.40 15 0..41 20 0..42 17 0..40 NT NT 13 0 .35 19 0 .35 13 0 .34 16 0 .34 14 0 .34 14 0 .41 16 0 .35 15 0 .35 17 0 .30 78 71 101 91 83 74 83 102 74 71 NT 91 84 73 82 98 102 64 128 82 Company Sanitized. Does not contain T S C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plas SICT AST i u /l ALT IU/L Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 TRACE TRACE SMALL NONE NONE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE isle, Group: VIII - 250 mg/kg 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE TRACE TRACE TRACE TRACE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Day 45 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 91 66 72 60 77 105 66 58 102 73 64 66 69 52 70 81 63 78 75 72 29 31 28 30 37 28 24 29 40 37 29 26 48 22 35 29 27 27 23 22 801 DuPont-5386 ima Chemistry Values SDH lU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 14 .0 10..5 13..7 15..1 16..3 21..9 13 .9 15..5 20..4 21..6 14 .0 13 ,.0 19..9 9 .4 19 .1 16,.4 14..7 15..1 25..1 11..2 81 0 .13 93 0 .15 67 0..13 58 0 .10 95 <0,.10 114 0..12 61 0..10 80 0..17 102 <0..10 78 <0..10 87 <0..10 73 0..10 73 <0 .10 87 0..12 75 <0..10 71 0,.12 102 <0 .10 61 0..14 118 0 ,.13 61 <0..10 16 0,.39 15 0..31 12 0 .28 16 0 .41 19 0 .33 19 0..42 13 0 .34 17 0..34 14 0..32 16 0..33 15 0..43 15 0 .26 15 0,.31 16 0..36 19 0 .36 16 0 .35 17 0..37 13 0..31 14 0,.51 17 0..39 82 94 74 81 63 70 107 85 77 89 72 68 108 87 89 88 102 100 91 117 Company Sanilfced. Dosa ,,o l contain rsCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmoI/L Female, Group: II - 0 mg/kg - Day 45 643354 643361 41 104 7.1 4.5 2.6 10.5 6.8 142.8 82 98 7.1 4.9 2.2 11.1 7.7 143.0 643362 42 101 6.9 4.5 2.4 10.7 6.8 141.3 643374 43 92 7.1 5.0 2.1 11.4 7.4 145.5 643398 78 97 6.6 4.7 1.9 10.7 8.0 142.2 643406 63 84 7.4 5.1 2.3 11.0 7.4 142.1 643436 95 94 7.8 5.5 2.3 11.0 7.4 142.1 643463 107 117 8.3 5.9 2.4 11.8 8.8 146.1 643477 41 98 7.7 5.5 2.2 11.1 8.0 148.5 643486 35 87 6.6 4.5 2.1 10.6 6.6 141.4 Female, Group: IV - 25 mg/kg - Day 45 643321 NT NT NT NT NT NT NT NT 643324 43 119 7.6 5.3 2.3 11.2 6.7 145.7 643364 34 95 6.9 4.7 2.2 11.1 7.5 144.0 643380 110 107 7.6 5.1 2.5 11.0 5.8 142.8 643389 124 133 6.7 4.2 2.5 11.3 10.0 148.1 643390 50 98 8.1 5.2 2.9 11.8 8.1 146.0 643396 128 109 7.7 5.4 2.3 12.0 8.6 142.1 643410 70 113 7.4 5.2 2.2 11.0 7.3 140.0 643433 114 115 7.4 5.3 2.1 11.2 7.4 141.8 643458 25 90 7.0 4.7 2.3 10.5 7.1 140.8 K mmol/L 5.59 5.71 5.60 6.11 5.56 5.75 5.55 5.53 5.87 5.37 NT 5.29 5.99 5.27 6.52 5.82 5.90 5.58 5.42 5.81 CL mmol/L 101.5 100.2 100.8 100.6 101.6 100.6 100.4 99.0 102.2 100.6 NT 100.8 101.7 100.1 102.6 99.4 97.2 98.6 99.8 99.1 SPEC Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 23 96 8.2 5.8 2.4 11.4 8.0 143.5 28 99 7.5 5.3 2.2 11.1 7.5 141.6 54 109 7.4 5.3 2.1 11.0 7.5 142.4 84 99 8.2 5.5 2.7 11.9 7.4 142.9 36 96 7.8 5.4 2.4 11.4 8.3 142.8 34 89 7.1 4.9 2.2 10.6 8.6 143.6 53 98 7.7 5.5 2.2 11.3 7.6 139.8 47 94 7.6 5.2 2.4 11.4 7.9 141.9 31 98 7.7 5.4 2.3 11.2 9.0 141.0 53 98 7.6 5.4 2.2 11.1 7.2 145.6 tale, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 26 101 8.4 5.9 2.5 11.8 7.9 142.6 45 113 8.1 5.7 2.4 12.0 7.2 142.7 52 95 8.1 5.6 2.5 11.8 8.6 143.4 43 100 8.2 5.9 2.3 12.0 8.7 142.4 58 96 8.9 6.0 2.9 12.2 8.0 144.1 34 112 8.3 5.9 2.4 11.7 7.9 142.8 35 98 7.9 5.4 2.5 11.4 7.7 142.8 65 100 7.5 5.5 2.0 11.2 7.5 142.9 33 101 8.6 6.0 2.6 12.1 7.6 146.7 30 94 7.5 5.3 2.2 11.1 7.1 142.6 k mmol/L 5.91 5.40 6.12 5.91 6.26 5.77 5.95 6.17 5.83 5.45 5.94 5.88 6.33 6.05 6.57 6.41 6.32 6.32 6.98 6.42 CL mmol/L 101.5 100.8 99.6 97.9 98.2 100.7 99.8 98.3 100.3 100.0 99.6 100.2 97.8 98.5 98.4 100.7 99.7 99.7 100.0 100.4 SPEC Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number SHEM SLIP Individual Serum and Plasma Chemistry Values SICT AST IU/L ALT IU/L SDH IU/L ALKP IU/L Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 b4jjyy 64J4Ub b4J43b b4J4b5 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE SMALL NONE NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 93 643321 43324 b43 3 b4 643380 643389 643390 b4 33yb b4341U 643433 643458 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE 106 76 92 160 88 72 67 76 77 89 NT 67 116 71 86 71 60 78 75 85 37 11.0 39 20.5 29 9.3 52 36.9 28 19.8 25 18.4 26 19.0 28 19.0 35 20.5 28 14.8 NT NT 26 18.0 40 8.3 28 17.3 46 16.5 32 20.7 34 17.8 29 20.3 27 13.4 32 15.1 60 38 49 32 52 38 29 34 47 36 NT 52 28 36 65 47 25 27 44 72 BILI mg/dL <0.10 0.11 0.11 0.22 0.12 0.16 <0.10 0.15 0.20 0.17 NT 0.10 <0.10 0.13 <0.10 <0.10 0.13 0.12 0.17 0.13 BUN mg/dL 20 18 16 16 15 18 15 13 17 17 NT 13 18 14 20 15 16 17 17 15 CREA mg/dL 0.41 0.48 0.41 0.46 0.54 0.56 0.46 0.52 0.42 0.48 NT 0.45 0.41 0.39 0.40 0.48 0.44 0.42 0.46 0.52 CHOL mg/dL 65 78 92 108 66 73 70 91 74 77 NT 88 83 73 94 92 125 60 109 86 Com pany Sanitized. Does not contain T S C A ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE TRACE SMALL NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE 99 93 70 91 83 90 100 88 100 76 126 NT 97 59 98 82 73 84 88 77 28 34 28 41 30 31 36 34 35 36 57 NT 71 28 29 39 40 26 28 28 805 I DuPont-5386 Chemistry Values SDH ItJ/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 10 .2 20..9 13 .3 17..5 23 .3 16..0 23..3 18..4 21..3 18.,5 21.7 NT 25.1 12.6 9.7 22.5 17.5 15.6 15.4 14.6 63 0..14 62 <0..10 40 0..20 34 <0..10 72 <0..10 58 0..10 40 <0..10 44 0..10 75 0..11 64 0..10 76 <0 .10 NT NT 50 <0 .10 58 0,.13 39 0..14 37 0 .14 53 <0 .10 42 0 .15 84 0 .13 29 0 .12 17 0..60 13 0 .51 12 0 .50 15 0 .44 17 0 .53 21 0..38 13 0..57 17 0..48 17 0..64 14 0..44 16 0 .47 NT NT 15 0 .49 14 0 .42 15 0 .59 15 0 .59 16 0 .47 16 0 .50 19 0 .51 17 0 .44 71 73 64 85 57 73 93 71 73 101 68 NT 101 96 110 92 105 104 59 120 Company Sanitized. Does not contain T S C A CBS I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________ I DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: II - 0 mg/kg - Day 93 643354 61 84 7.1 4.5 2.6 10.5 6.4 142.8 643361 453 101 7.9 5.4 2.5 11.0 5.6 140.9 643362 92 92 6.7 4.5 2.2 10.6 6.1 143.2 643374 122 87 8.4 6.1 2.3 11.4 4.9 143.1 643398 63 99 6.9 4.7 2.2 10.4 6.1 146.1 643406 75 76 7.5 5.1 2.4 10.7 5.6 142.8 643436 363 96 7.8 5.4 2.4 10.9 6.3 143.4 643463 158 100 8.1 5.8 2.3 11.0 4.5 144.4 643477 113 89 7.5 5.6 1.9 10.9 5.3 146.0 643486 95 91 7.4 5.0 2.4 10.5 4.9 144.0 Female, Group: IV - 25 mg/kg - Day 93 643321 NT NT NT NT NT NT NT NT 643324 74 101 7.8 5.4 2.4 10.7 5.8 143.6 643364 52 92 7.6 5.2 2.4 10.9 5.8 142.4 643380 166 99 7.9 5.5 2.4 11.0 6.0 141.2 643389 52 91 7.6 4.9 2.7 10.5 6.7 141.2 643390 76 96 8.2 5.6 2.6 11.4 5.7 146.0 643396 151 96 8.7 6.3 2.4 12.0 6.4 143.0 643410 64 105 7.8 5.6 2.2 11.0 5.0 143.8 643433 110 101 7.5 5.2 2.3 10.7 6.5 141.3 643458 42 95 7.4 5.0 2.4 10.5 5.9 143.1 K mmol/L 5.76 4.68 5.33 5.06 5.29 5.59 5.32 4.93 5.84 5.14 NT 5.21 5.75 5.18 5.48 5.63 5.15 5.01 5.22 5.02 CL mmol/L 102.8 98.4 100.6 95.9 101.9 97.6 99.0 97.8 97.6 100.3 NT 97.1 103.8 97.7 98.8 98.7 95.3 100.1 99.2 99.1 PHEM NONE SMALL NONE NONE NONE NONE TRACE NONE NONE TRACE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE Company Sanitized. Does not contain T S C A CBI 806 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP /dL alb g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: VI - 100 mg/kg - ay 93 643322 41 84 8.3 6.0 2.3 11.3 6.4 141.4 643323 29 129 8.4 6.0 2.4 12.0 9.5 147.0 643366 74 108 8.1 6.0 2.1 11.4 5.4 143.7 643367 100 87 8.3 5.8 2.5 11.2 5.2 142.0 643392 32 98 8.7 6.1 2.6 11.4 6.8 145.5 643409 37 93 7.5 5.4 2.1 10.6 5.8 142.2 643461 40 128 8.5 5.9 2.6 11.6 8.4 147.6 643462 49 84 8.0 5.9 2.1 11.2 6.8 142.8 643472 44 84 9.1 6.5 2.6 11.4 6.7 145.3 643489 81 101 8.3 5.9 2.4 11.1 6.1 143.3 Female, Group: VIII - 250 mg/kg - Day 93 643332 56 97 8.8 6.2 2.6 11.6 6.8 144.1 643340 NT NT NT NT NT NT NT NT 643341 61 98 8.7 6.0 2.7 11.4 6.2 142.0 643359 69 92 8.5 6.0 2.5 12.0 7.2 144.4 643370 88 99 9.1 6.1 3.0 11.9 7.7 141.6 643404 27 97 8.9 6.2 2.7 11.7 6.5 145.0 643408 57 90 7.9 5.4 2.5 10.9 6.4 144.1 643435 26 85 8.6 6.3 2.3 11.6 7.3 143.2 643446 28 93 8.3 6.0 2.3 11.3 5.6 141.9 643466 72 91 8.7 6.2 2.5 11.4 5.6 142.3 K mmol/L 5.35 5.54 5.74 5.16 6.17 5.06 6.22 5.92 5.61 5.41 5.86 NT 5.86 6.22 5.95 5.87 5.91 6.95 5.53 6.27 CL mmol/L 99.1 103.6 99.3 96.4 99.4 97.7 101.5 100.0 98.5 97.7 98.8 NT 95.0 97.8 97.4 99.4 99.2 98.3 96.7 98.5 PHEM NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE Company Sanitized. Does not contain T S C A CB! I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________ Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU ug/mL SPEC Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.3 0.1 0.2 0.1 0.1 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR 0.2 0.2 0.2 0.4 0.2 0.2 0.2 0.2 0.2 I DuPont-5386 Company Sanitized. Does not contain T S C A CB1 808 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU pg/mL SPEC Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE: NONE: NONE: NONE: NONE: NONE; NONE: NONE; NONE: NONE: NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.5 0.3 0.4 0.5 0.4 0.2 0.4 0.4 0.4 0.2 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE: NT' NONE: NONE: NONE: NONE: NONE NONE; NONEI NONE: NONE NT NONE NONE NONE TRACE NONE NONE NONE NONE 1.1 NSR 1.0 0.6 1.0 0.6 0.7 1.0 0.6 0.6 DuPont-5386 Com pany Sanitized. Does no! contain T S C A C B i ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plas SICT AST IU/L ALT U/L Female, Group: II - 0 mg/kg - Day 125 643330 NONE NONE NONE 90 42 643336 NSR NT NT NT NT 643377 NONE NONE NONE 132 83 643387 NONE NONE NONE 74 26 643405 NONE NONE NONE 223 129 643415 NONE NONE NONE 224 126 643425 TRACE NONE NONE 138 72 643426 NONE NONE NONE 80 31 643448 NONE NONE NONE 87 46 643453 NONE NONE NONE 70 34 Female, Group: VIII mg/kg - Day 125 643345 NONE NONE NONE 75 31 643347 NONE NONE NONE 72 40 643351 NONE NONE NONE 84 25 643358 NONE NONE NONE 95 48 643423 NONE NONE NONE 131 42 643441 NONE TRACE NONE 81 34 643444 NONE NONE NONE 712 264 643456 NONE NONE NONE 70 29 643474 NONE NONE NONE 119 48 643481 NONE NONE NONE 82 60 810 DuPont-5386 ma Chemistry Values SDH IV/h ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 16.9 NT 25.8 14.0 49.6 39.0 31.6 18.7 19.4 17.6 15.1 16.9 17.2 17.4 16.9 18.1 103.2 14.4 12.0 18.4 24 0.16 NT NT 21 0.14 31 <0.10 46 0.12 18 <0.10 58 <0.10 35 0.14 33 0.12 34 0.11 28 <0.10 43 0.11 41 <0.10 32 0.10 72 0.12 39 0.11 36 0.24 24 <0.10 40 <0.10 24 <0.10 17 0.58 NT NT 12 0.48 18 0.45 17 0.56 13 0.44 17 0.44 13 0.49 21 0.43 16 0.43 15 0.45 17 0.50 16 0.56 18 0.49 17 0.51 15 0.44 16 0.48 12 0.41 19 0.46 18 0.52 115 NT 127 75 83 172 83 136 55 108 58 65 64 140 85 87 224 107 62 92 Company Sanitized. Does not contain T S C A CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Female, Group: II - 0 mg /kg - Day 125 643330 85 116 8.9 6.0 2.9 643336 NT NT NT NT NT 643377 127 92 8.8 6.1 2.7 643387 81 103 8.1 5.5 2.6 643405 219 155 8.1 5.6 2.5 643415 271 92 8.8 5.8 3.0 643425 58 108 7.5 5.3 2.2 643426 162 99 8.1 5.7 2.4 643448 71 97 7.5 5.5 2.0 643453 148 99 8.1 5.5 2.6 Female, Group: VIII - 250 mg/kg - Day 125 643345 36 99 7.7 5.3 2.4 643347 46 94 8.5 5.6 2.9 643351 71 117 7.4 5.2 2.2 643358 248 100 8.8 6.1 2.7 643423 37 110 8.2 5.2 3.0 643441 306 135 7.8 5.4 2.4 643444 74 97 8.7 5.6 3.1 643456 56 85 8.1 5.3 2.8 643474 34 99 8.2 5.6 2.6 643481 114 106 8.5 5.8 2.7 811 DuPont-5386 ima Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 11.3 NT 11.4 10.9 11.9 11.3 10.3 11.0 10.5 11.0 10.6 10.8 10.9 11.3 10.9 10.7 11.3 10.5 10.6 11.4 6.3 145.1 NT NT 4.8 145.8 5.2 144.8 7.8 147.5 5.0 146.0 4.9 146.5 5.6 145.7 5.9 145.2 5.9 142.7 6.0 145.3 5.3 146.6 7.4 144.1 7.5 142.4 8.1 143.4 5.7 145.0 5.8 142.6 6.2 142.6 6.1 140.8 5.6 145.8 5.17 NT 4.90 5.86 5.86 4.98 5.59 4.78 4.91 5.70 5.36 5.51 6.10 5.38 4.7 6 4.85 5.92 5.28 5.18 6.11 103.1 NT 100.9 104.3 103.3 101.7 104.7 101.2 103.0 101.1 102.7 102.2 105.0 100.5 105.3 105.5 102.0 101.2 104.1 103.8 NONE NT NONE TRACE NONE NONE NONE TRACE TRACE NONE NONE NONE NONE TRACE NONE NONE NONE NONE TRACE NONE Company Sanitized. Does not contain TSCACBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU pg/mL Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 NONE NT NONE NONE NONE TRACE NONE NONE NONE TRACE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE 0.1 NT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 DuPont-5386 Company Sanitized. Does not contain TSCA CBI >) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group: 1 - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR HAZY HAZY CLOUDY CLOUDY CLOUDY HAZY HAZY HAZY Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLOUDY HAZY HAZY CLEAR HAZY CLEAR CLOUDY CLOUDY CLOUDY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 10.4 3.9 6.9 8.6 10.8 3.6 12.4 21.4 4.4 3.2 16.8 4.6 19.0 7.0 4.6 14.2 5.8 11.0 5.6 11.0 782 1373 1179 1363 1083 1631 967 526 1519 1404 1.024 1.043 1.036 1.042 1.031 1.052 1.029 1.017 1.047 1.044 547 1724 684 1003 1625 618 1689 844 659 799 1.018 1.053 1.021 1.033 1.049 1.020 1.051 1.027 1.021 1.026 7.0 NEGATIVE 15 NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE TRACE 6.5 NEGATIVE 5 SMALL SMALL 8.0 NEGATIVE NEGATIVE NEGATIVE SMALL 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 6.5 NEGATIVE 8.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 7.5 NEGATIVE 8.5 NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 15 SMALL MODERATE 5 NEGATIVE NEGATIVE 5 NEGATIVE LARGE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE MODERATE 15 NEGATIVE MODERATE 5 NEGATIVE MODERATE Company Sanitized. Does not contain TSCA CBi 813 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY HAZY CLEAR CLOUDY HAZY CLOUDY HAZY Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY HAZY CLEAR HAZY CLEAR HAZY HAZY CLEAR CLEAR Individual Urinalysis Values VOL mil UOSM mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 17.8 3.3 3.3 4.0 3.9 4.8 13.4 6.0 16.2 7.4 5.5 3.2 9.6 5.6 23.5 7.8 25.0 11.8 59.0 20.4 611 1924 QNS 2334 1663 1394 820 1352 591 1305 1219 2502 848 1609 419 838 505 743 217 475 1.020 1.058 1.075 1.068 1.051 1.044 1.025 1.043 1.019 1.042 1.039 1.068 1.026 1.050 1.014 1.027 1.016 1.024 1.007 1.016 7.0 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 8.5 NEGATIVE 7.0 NEGATIVE 7.5 NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE TRACE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 8.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE SMALL 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE MODERATE Company Sani*. Does no! eontain TSCA CBI 814 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Male, Group: I - 0 mg/.kg - Day 44 643143 0.2 45 643150 0.2 84 643185 0.2 75 643189 0.2 149 643204 0.2 51 643205 0.2 119 643235 0.2 78 643241 0.2 20 643288 0.2 57 643300 0.2 93 Male, Group: III - 25 mg/kg - Day 44 643173 0.2 19 643179 1.0 175 643180 0.2 24 643228 0.2 50 643240 0.2 61 643264 0.2 21 643272 0.2 104 643290 0.2 50 643292 0.2 58 643308 0.2 63 FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5386 Company Sanitized. D oes not contain TSCA CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL Male, Group: V - 100 mg/kg - Day 643175 0.2 24 643224 0.2 163 643243 0.2 144 643247 0.2 152 643250 0.2 142 643257 0.2 151 643275 0.2 47 643311 0.2 81 643314 0.2 59 643318 0.2 63 Male, Group: VII - 250 mg/kg - D< 643174 0.2 81 643193 0.2 198 643194 0.2 51 643201 0.2 133 643215 0.2 16 643252 0.2 45 643259 0.2 22 643260 0.2 73 643298 0.2 10 643315 0.2 26 Individual Urinalysis Values ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR CLEAR HAZY HAZY CLEAR HAZY CLOUDY CLEAR CLEAR Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW BROWN YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR CLOUDY CLEAR HAZY CLOUDY HAZY HAZY CLOUDY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL 3.5 1.4 9.0 10.0 6.4 5.4 12.0 19.0 1.8 2.2 RNV 12.0 8.3 4.2 5.7 26.0 13.0 6.6 10.0 4.5 2200 UTD 1440 1289 1077 1367 1322 614 UTD UTD 1.064 1.076 1.044 1.040 1.035 1.045 1.044 1.022 >1.083 1.065 1134 744 851 1924 1366 560 784 1154 1119 1947 1.035 1.028 1.026 1.059 1.041 1.020 1.024 1.036 1.033 1.058 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE SMALL NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE LARGE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 MODERATE LARGE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE Company Sanitized. Does not contain T S C A CBI I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number QUAI, COL CLAR Male, Group: V - 100 ing/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT HAZY HAZY HAZY CLOUDY CLEAR CLOUDY CLEAR HAZY HAZY Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLOUDY CLEAR CLEAR CLEAR CLOUDY HAZY CLOUDY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG NSR 4.2 5.4 23.0 3.3 6.7 7.7 7.5 28.0 4.0 18.0 8.6 12.0 8.0 14.0 12.0 27.0 18.0 27.0 9.2 NT 1666 1948 642 2020 1414 1167 1088 376 1510 NT 1.049 1.058 1.021 1.061 1.043 1.036 1.035 1.014 1.047 53 5 1181 892 1221 111 909 540 452 443 1037 1.020 1.037 1.031 1.039 1.024 1.029 1.019 1.015 1.017 1.034 818 ) DuPont-5386 pH UGLU KET mg/dL mg/dL UBIL BLD NT NT NT NT NT 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE SMALL 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE 15 SMALL NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE Com pany Sanitized. Does H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU yg UMTP mg/dL Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 0.2 15.9 0.2 QNS 0.2 28.7 0.2 22.6 0.2 15.1 0.2 16.0 0.2 25.1 0.2 18.0 0.2 QNS 0.2 QNS Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 0.2 QNS 0.2 185.6 0.2 263.3 1.0 197.0 0.2 173.8 0.2 251.4 0.2 197.9 0.2 192.0 0.2 267.7 0.2 188.2 147 149 74 102 76 86 74 25 177 276 51 34 40 184 49 15 23 113 81 187 Individual Urinalysis Values SPEC Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: PARTIAL VOLUME / ACCIDIDENTAL SPILLAGE DuPont-5386 Company Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU ug UMTP mg/dL Male, Group: V - 100.mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NSR 0.2 379.3 0.2 761.9 0.2 988.9 0.2 710.4 0.2 839.7 0.2 540.2 0.2 587.6 0.2 676.5 0.2 480.0 NT 95 151 23 168 115 64 63 32 104 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 0.2 1911.3 0.2 1537.7 0.2 1378.9 0.2 1093.7 0.2 1259.4 0.2 1595.8 0.2 1947.2 0.2 992.5 0.2 1592.1 0.2 1427.1 24 56 63 71 27 30 17 21 35 56 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED ) DuPont-5386 Company Sanilizecf. Does nof contain T S C A CB 820 >) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR CLEAR CLEAR HAZY HAZY HAZY CLEAR HAZY CLEAR Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 LIGHT MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY HAZY HAZY HAZY HAZY HAZY CLEAR HAZY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 13.4 8.7 17.8 14.2 10.4 5.9 7.9 11.8 6.7 23.2 6.5 3.5 4.2 2.0 4.1 13.4 3.2 21.0 11.2 3.1 803 984 501 744 853 1450 1391 1033 1357 404 1.026 1.031 1.017 1.025 1.027 1.046 1.043 1.034 1.043 1.014 1048 1971 1714 3194 2244 723 2743 642 744 2569 1.034 1.059 1.051 1.082 1.064 1.025 1.074 1.021 1.025 1.073 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE Company Sanitized. Does not contain T S C A CBI 821 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU yg UMTP mg/dL Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 0.2 11.9 0.2 10.3 0.2 16.0 0.2 16.9 0.2 12.6 0.2 10.0 0.2 15.7 0.2 18.3 0.2 15.0 0.2 15.7 Male, Group: VII - 250 mg/kg - Day 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 0.2 76.9 0.2 55.0 0.2 96.0 0.2 78.1 0.2 103.7 0.2 109.1 0.2 85.7 0.2 131.3 0.2 71.2 0.2 66.6 74 45 41 29 30 116 88 52 176 13 !5 41 134 86 234 121 57 197 73 44 220 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number UFLU ug Male , Group: I - 0 mg/kg - Day 181 643145 643210 643232 643265 643268 9.7 9.8 20.7 9.5 10.7 Male , Group: III - 25 mg/kg - Day 181 643202 643293 643305 643306 643310 21.4 25.0 26.7 18.6 22.4 Male , Group: V - 100 mg/kg - Day 181 643159 643169 643181 643206 643286 52.2 34.7 41.0 21.9 45.6 Male , Group: VII - 250 mg/kg - Day 181 643149 643152 643178 643283 643295 64.4 64.2 71.0 79.9 66.0 Individual Urinalysis Values DuPont-5386 Company Sanitized. Does not contain T S C A CBt I! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAK Female, Group:: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 LIGHT LIGHT MEDIUM LIGHT NT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR HAZY CLOUDY NT HAZY CLOUDY CLOUDY HAZY CLEAR Female, Group:: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT HAZY CLEAR HAZY CLEAR HAZY HAZY CLEAR HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 9.0 11.2 1.3 5.4 QNS 12.0 6.2 2.8 1.0 2.9 NSR 10.0 3.2 12.0 3.6 5.0 9.8 7.5 1.6 9.2 583 705 3203 779 NT 578 681 2172 QNS 1468 1.018 1.022 1.068 1.023 NT 1.017 1.022 1.062 >1.083 1.044 NT 782 847 802 1461 1085 650 915 2888 620 NT 1.024 1.026 1.024 1.044 1.034 1.020 1.028 1.074 1.019 8.5 NEGATIVE NEGATIVE NEGATIVE MODERATE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE TRACE NT NT NT NT NT 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE NEGATIVE SMALL TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain T S C A CBI 824 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations I DuPont-5386 Animal Number QUAL COL CLAR Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR HAZY Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY HAZY CLEAR CLEAR CLOUDY HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsmYkg SG pH UGLU mg/dL KET mg/dL UBIL BLD 12.0 12.4 11.2 8.8 4.0 2.1 5.6 7.8 6.2 11.4 16.0 17.0 20.4 11.2 6.4 15.6 12.2 8.2 7.0 12.2 482 470 633 843 1036 1265 907 840 775 608 1.015 1.015 1.019 1.025 1.031 1.038 1.027 1.025 1.024 1.019 414 471 377 680 1011 427 507 683 760 555 1.013 1.015 1.012 1.021 1.030 1.014 1.016 1.021 1.023 1.017 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain T S C A CB1 825 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Female, Group: II - 0 mg/kg - Day 45 643354 0.2 24 FECAL CONTAMINATION OBSERVED 643361 0.2 12 643362 0.2 72 Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME 643374 0.2 12 643398 NT QNS 643406 0.2 12 643436 0.2 29 FECAL CONTAMINATION OBSERVED 643463 0.2 88 FECAL CONTAMINATION OBSERVED 643477 0.2 94 Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME 643486 0.2 25 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 NT 14 FECAL CONTAMINATION OBSERVED 16 15 30 21 13 16 80 9 DuPont-5386 Company Sanitized. Does not contain T S C A CBI 826 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Female, Group: VI - 100 mg/kg - Day 45 543322 643323 643356 643367 643392 643409 643461 643462 643472 643489 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 13 12 FECAL CONTAMINATION OBSERVED 12 18 20 26 24 22 17 11 Female, Group: :ii - 250 mg/kg Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 14 11 9 41 37 11 28 20 FECAL CONTAMINATION OBSERVED 26 17 DuPont-5386 C o m p ly Smlfbetf. Does not Contain TS CA CB I II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations I DuPont-5386 Animal Number QUAL COL CLAR Female, Group:: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 LIGHT DARK MEDIUM DARK NT NT MEDIUM DARK DARK NT YELLOW YELLOW YELLOW YELLOW NT NT YELLOW YELLOW YELLOW NT CLOUDY CLOUDY CLEAR HAZY NT NT HAZY HAZY HAZY NT Female, Group : IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM NT MEDIUM DARK NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW NT HAZY HAZY HAZY CLEAR CLEAR CLEAR NT HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 9.4 771 1.023 4.8 1080 1.034 3.0 1684 1.049 0.6 NT QNS QNS NT NT QNS NT NT 1.5 UTD 1.071 0.9 UTD >1.083 1.5 QNS >1.083 QNS NT NT NSR NT NT 6.6 1030 1.029 5.4 1096 1.034 8.6 760 1.023 2.2 1722 1.051 3.0 1610 1.049 4.0 1368 1.043 QNS NT NT 7.5 843 1.026 1.6 UTD 1.081 7.5 NEGATIVE NEGATIVE NEGATIVE MODERATE 8.0 NEGATIVE NEGATIVE SMALL MODERATE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE SMALL TRACE NT NT NT NT NT NT NT NT NT NT 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 6.5 NEGATIVE TRACE SMALL NEGATIVE 5.5 NEGATIVE 5 SMALL TRACE NT NT NT NT NT NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE MODERATE 7.5 NEGATIVE NEGATIVE NEGATIVE SMALL 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE SMALL 6.5 NEGATIVE 5 SMALL NEGATIVE Company Sanitized. Does not contain TS C A CBI 828 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 Animal Number QUAL COL CLAR Female, Group : VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 DARK MEDIUM LIGHT MEDIUM MEDIUM DARK DARK DARK MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR CLEAR CLOUDY HAZY CLEAR CLEAR CLEAR Female, Group : VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 LIGHT NT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY NT CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 1.8 8.3 9.4 1.5 2.0 2.5 2.6 3 .4 1.7 7.0 12.4 NSR 7.9 24.0 23.4 3.5 6.3 5.3 6.5 7.0 UTD 759 579 2411 1513 2065 1715 1750 2013 1067 1.068 1.025 1.019 1.066 1.047 1.059 1.054 1.053 1.057 1.031 539 NT 815 429 403 812 1033 816 1216 812 1.019 NT 1.024 1.015 1.013 1.026 1.030 1.026 1.039 1.024 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE SMALL SMALL 5.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE Company Sanitized. Does not contain TSCA CBI 829 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU pg UMTP mg/dL female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 0.2 14.0 0.2 19.4 0.2 QNS 0.2 QNS NT QNS NT QNS 0.2 QNS 0.2 QNS 0.2 QNS QNS 19 61 30 QNS QNS QNS 152 140 99 QNS Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NSR 0.2 100.5 0.2 107.9 0.2 52.2 0.2 QNS 0.2 84.2 0.2 99.7 NT QNS 0.2 150.5 0.2 QNS NT 14 26 25 38 41 145 QNS 25 75 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5386 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU pg UMTP mg/dL Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 0.2 QNS 0.2 513.2 0.2 349.2 0.2 QNS 0.2 QNS 0.2 QNS 0.2 QNS 0.2 363.9 0.2 QNS 0.2 615.0 92 16 13 80 48 90 79 75 52 20 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 0.2 711.2 NT NSR 0.2 500.1 0.2 1902.8 0.2 2039.6 0.2 519.8 0.2 679.6 0.2 454.7 0.2 931.7 0.2 493.0 47 NT 21 57 50 48 114 29 67 54 Individual Urinalysis Values DuPont-5386 Company Sanitized. Does not contain T S C A CBF 831 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Female, Group:: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 LIGHT NT LIGHT MEDIUM LIGHT MEDIUM LIGHT MEDIUM MEDIUM LIGHT YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR NT CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR Female, Group:: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 LIGHT LIGHT LIGHT NT LIGHT MEDIUM NT LIGHT MEDIUM NT YELLOW YELLOW YELLOW NT YELLOW YELLOW NT YELLOW YELLOW NT CLEAR CLEAR CLEAR NT CLEAR HAZY NT HAZY CLEAR NT Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 2.8 NT 3.5 2.6 7.9 3.2 15.4 1.0 1.2 9.0 11.0 4.8 4.9 QNS 7.9 3.3 QNS 9.0 2.8 QNS 1123 NT 1073 1589 894 1094 389 QNS QNS 668 1.036 NT 1.035 1.049 1.027 1.036 1.014 1.076 1.070 1.021 495 951 1042 QNS 594 1704 QNS 476 1617 QNS 1.018 1.029 1.033 NT 1.019 1.052 NT 1.017 1.048 NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT Company Sanitized.Does nof contain TSCA 832 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU pg UMTP mg/dL Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 0.2 3.6 NT NT 0.2 5.6 0.2 5.5 0.2 11.6 0.2 6.4 0.2 18.4 0.2 QNS 0.2 QNS 0.2 8.9 81 NT 29 57 26 428 7 185 80 90 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 0.2 30.3 0.2 30.0 0.2 49.7 NT QNS 0.2 40.0 0.2 38.9 NT QNS 0.2 73.6 0.2 44.2 NT QNS 12 100 25 QNS 23 49 QNS 228 48 QNS Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED Sample status: Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME URINALYSIS TO BE RUN MANUALLY - LOW VOLUME DuPont-5386 Company Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number UFLU pg Female, Group: II - 0 mg/kg - Day 181 643383 643384 643402 643465 643484 12.7 8.6 6.1 12.3 4.1 Female, Group: IV - 25 mg/kg - Day 181 643379 643391 643411 643437 643483 12.9 11.1 NT 23.8 QNS Female, Group: VI - 100 mg/kg - Day 181 643360 643373 643381 643382 643412 24.6 23.1 18.2 23.1 11.0 Female, Group: VIII 250 mg/kg - Day 181 643329 643356 643388 643450 643487 17.2 28,7 QNS 47.7 23.6 Individual Urinalysis Values ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Nuniber EPIT UWBC URBC Individual Urine Microscopic NCRY MICE SPER Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE FEW NONE NONE FEW NONE 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 1-10 0 1-10 0 0 0 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE FEW FEW NONE NONE NONE NONE NONE NONE NONE 00 00 00 0 >50 00 00 00 00 00 00 FEW FEW FEW FEW MODERATE FEW FEW FEW FEW MANY MODERATE FEW FEW NONE FEW FEW FEW MODERATE NONE MODERATE MANY MODERATE MODERATE MODERATE MANY MANY MANY MODERATE MANY MANY MODERATE MANY MANY MODERATE MODERATE MODERATE FEW MANY MANY MANY 3 2 1 2 0 1 1 0 3 0 2 1 2 2 1 2 0 1 1 1 835 Values SPEC DuPont-5386 Company SMB*. Does Mnlai,, TSCA CB| H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPXT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NONE NONE FEW NONE NONE NONE FEW NONE NONE NONE 0 0 0 0 1-10 0 0 Q 0 0 0 0 0 1-10 0 0 0 0 0 0 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE FEW NONE NONE NONE NONE FEW NONE FEW 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1-10 NONE FEW FEW FEW NONE FEW FEW FEW FEW MODERATE FEW MODERATE FEW FEW MODERATE NONE FEW NONE FEW FEW MANY MODERATE FEW MODERATE FEW FEW MANY MANY MANY MODERATE MANY FEW MODERATE FEW MODERATE MODERATE MODERATE MANY MODERATE MODERATE 0 1 1 1 1 0 1 0 1 2 2 2 1 FEW COARSELY GRANULAR CASTS 2 2 1 2 0 1 2 DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Male, Group: I ~ 0 mg/kg - Day 91 643143 FEW 0 0 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE FEW FEW FEW NONE FEW NONE NONE FEW 00 0 1-10 0 1-10 00 00 00 00 00 00 Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE FEW NONE NONE NONE NONE NONE NONE 1-10 0 0 0 0 0 0 0 0 0 0 1-10 0 >50 0 0 0 0 0 0 FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW NONE NONE NONE FEW FEW FEW FEW FEW MODERATE FEW FEW MANY MODERATE FEW FEW FEW FEW FEW FEW NONE MANY FEW FEW FEW MODERATE MODERATE MODERATE MODERATE FEW W tO tO PW PH W W W 2 1 2 3 1 1 2 1 1 1 Values SPEC DuPont-5386 sample status: BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS Sample status: BELOW RECOMMENDED VOLUME 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME Sample status: Sample status: BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Male, Group:: V. - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR FEW NONE FEW FEW FEW MODERATE FEW NONE NONE NT 0 0 0 0 0 0 0 0 0 Male, Group:: VII - 250 mg/kg - Day 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 FEW FEW FEW NONE NONE NONE FEW NONE NONE NONE 0 0 0 0 0 0 0 0 0 0 NT 1-10 0 0 0 1-10 0 0 0 0 NT NONE FEW FEW FEW FEW FEW FEW FEW FEW 0 0 0 1-10 0 0 0 0 0 0 NONE NONE FEW FEW FEW FEW NONE FEW FEW MODERATE NT MANY MODERATE FEW MODERATE MANY MANY MODERATE MANY FEW MANY MANY FEW MODERATE FEW MODERATE MANY FEW MANY MODERATE NT 2 2 2 1 3 1 1 1 1 3 1 2 3 1 2 3 1 2 2 Values SPEC ) DuPont-5386 Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME 1-MUCUS 1-MUCUS Com pany Sanitized. Does not contain T S C A CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number SPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 FEW NONE FEW NONE FEW NONE FEW FEW FEW FEW 1-10 0 0 0 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 0 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 NONE FEW FEW NONE 0 1-10 0 0 0 0 1-10 0 643234 643236 643258 643266 643296 643316 NONE FEW NONE NONE NONE NONE 0 1-10 1-10 0 0 0 1-10 1-10 0 0 0 0 NONE NONE NONE NONE NONE FEW FEW NONE FEW NONE NONE FEW MODERATE FEW MODERATE NONE FEW NONE NONE FEW MODERATE FEW MODERATE FEW MODERATE MODERATE MODERATE FEW MODERATE FEW MODERATE MODERATE MODERATE MODERATE MODERATE FEW MODERATE FEW FEW MANY 3 2 3 3 3 3 2 3 3 3 3 3 0 3 2 3 1 3 2 2 839 Values SPEC DuPont-5386 1-MUCUS 1-MUCUS 1-MUCUS 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME; 2-MUCUS; FEW COARSELY GRANULAR CASTS Sample status: BELOW RECOMMENDED VOLUME 1-MUCUS; MODERATE NUMBER OF RENAL EPITHELIAL CELLS Sample status: BELOW RECOMMENDED VOLUME 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS Company Sanitized. Does not contain T S C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC RBC Individual Urine Microscopic NCRY MICR SPER Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE FEW FEW FEW QNS FEW NONE FEW FEW FEW 0 0 1-10 0 NT 0 0 1-10 0 1-10 0 MODERATE MANY 0 NONE FEW 0 FEW FEW 0 NONE MODERATE NT NT NT 0 FEW MODERATE 0 MODERATE MANY 0 MODERATE FEW 0 NONE FEW 0 FEW FEW Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE FEW FEW FEW FEW NONE FEW NONE NT 0 0 0 0 1-10 0 0 1-10 0 NT NT NT 0 FEW MODERATE 0 MODERATE MODERATE 0 FEW MODERATE 0 FEW FEW 0 NONE FEW 0 MODERATE MODERATE 0 FEW MODERATE 0 FEW FEW 0 MODERATE MANY 0 0 0 0 NT 0 0 0 0 0 NT 0 0 0 0 0 0 0 0 0 840 Values SPEC ) DuPont-5386 Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME; 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME Sample status: BELOW RECOMMENDED VOLUME Company Sa n itized . Does nof contain TS C A CB[ ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC Individual Urine Microscopic NCRY MICR SPER Female, Group: VI - 100 mg /kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 FEW FEW FEW FEW NONE FEW NONE FEW NONE NONE 0 0 0 0 0 1-10 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NONE FEW FEW NONE NONE NONE FEW NONE FEW 0 0 0 0 0 0 0 1-10 0 1-10 0 0 0 0 0 0 0 0 0 0 FEW NONE FEW MODERATE NONE FEW MODERATE NONE FEW FEW MODERATE MODERATE FEW MODERATE FEW MODERATE FEW FEW MODERATE NONE MODERATE MANY MODERATE MODERATE FEW NONE MODERATE MANY FEW FEW MODERATE MODERATE MODERATE MANY MODERATE MODERATE MANY MODERATE MODERATE FEW 0 0 0 0 0 0 0 0 Q 0 0 0 0 0 0 0 0 0 0 0 841 Values SPEC DuPont-5386 Sample status: BELOW RECOMMENDED VOLUME Company Sanitized. Does not contain T S C A OBI !) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 FEW FEW FEW FEW QNS QNS NONE FEW 00 00 0 1-10 00 NT NT NT NT 00 00 643477 FEW 0 0 643486 QNS NT NT Female, Group: IV - 25 mg/kg - Day 93 643321 NSR NT NT 643324 FEW 0 0 643364 FEW 0 0 643380 FEW 00 643389 NONE 0 0 643390 NONE 0 0 643396 FEW 0 0 643410 QNS NT NT 643433 FEW 0 0 643458 FEW 0 0 Individual Urine Microscopic NCRY MICR SPER FEW FEW NONE NONE NT NT NONE FEW NONE NT MANY MANY MODERATE MANY NT NT MODERATE FEW MODERATE NT NT FEW FEW FEW NONE NONE NONE NT FEW NONE NT FEW MODERATE MANY FEW MODERATE MODERATE NT MODERATE MODERATE 0 0 0 0 NT NT 0 0 0 NT NT 0 0 0 0 0 0 NT 0 0 842 Values SPEC DuPont-5386 1-MUCUS 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS Sample status : BELOW RECOMMENDED VOLUME Sample status : BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS Sample status: BELOW RECOMMENDED VOLUME 1- MUCUS 2- MUCUS Sample status: Sample status: Sample status: BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME; 1-MUCUS BELOW RECOMMENDED VOLUME; 1-MUCUS 1-MUCUS Sample status: BELOW RECOMMENDED VOLUME Company Sanitized. Does not contain T S C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Anima 1 Number EPIT UWBC URBC Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 FEW FEW FEW FEW FEW FEW FEW FEW FEW NONE 00 00 00 00 0 1-10 00 00 00 00 0 1-10 Female, Group: VIII - 250 mg/kg - Day 93 643332 FEW 0 0 643340 NSR NT NT 643341 NONE 0 0 643359 FEW 0 0 643370 FEW 0 0 643404 FEW 0 0 643408 FEW 0 0 643435 FEW 0 0 643446 NONE 0 0 b4J4bb FEW 0 0 Individual Urine Microscopic NCRY MICE SPER NONE NONE NONE NONE NONE NONE NONE FEW NONE NONE FEW MODERATE MODERATE MODERATE FEW MANY MODERATE MODERATE FEW MODERATE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE FEW NT MODERATE MODERATE FEW FEW FEW MANY MODERATE MODERATE 0 0 0 0 0 0 0 0 0 0 0 NT 0 0 0 0 0 0 0 0 Values SPEC DuPont-5386 Sample status : 2-MUCUS 1-MUCUS Sample status : Sample status : Sample status : Sample status : Sample status : Sample status : 1-MUCUS BELOW RECOMMENDED VOLUME; 1-MUCUS BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME BELOW RECOMMENDED VOLUME; 1-MUCUS 1- MUCUS 2- MUCUS 1-MUCUS 1-MUCUS 1-MUCUS 1-MUCUS 1-MUCUS Company Sanitized. Does not contain T S C A CB1 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC 'emale, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 FEW NSR FEW FEW FEW NONE NONE FEW FEW NONE 1-10 NT 1-10 0 1-10 0 0 1-10 1-10 1-10 0 NT 0 0 0 0 0 0 0 0 'emale, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 FEW FEW FEW QNS FEW FEW QNS NONE FEW QNS 0 1-10 1-10 NT 1-10 1-10 NT 0 1-10 NT 0 0 0 NT 0 0 NT 0 0 NT Individual Urine Microscopic Values NCRY MICR SPER SPEC FEW FEW NT NT FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW NT NT FEW FEW FEW FEW NT NT FEW FEW FEW FEW NT NT 0 Sample status : BELOW RECOMMENDED VOLUME NT 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 0 0 NT 0 0 Sample status : BELOW RECOMMENDED VOLUME NT 0 0 Sample status : BELOW RECOMMENDED VOLUME NT SanRfe'- >notcontato TSCA CBI 844 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX L INDIVIDUAL HEPATIC BETA-OXIDATION ACTIVITY Company Sanitized. Does not contain T S C A CBI 845 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 10-Day Time Point Group I III V VII Animal Number 645904 645905 645906 645907 645908 645909 645910 645911 645912 645913 645914 645915 645916 645917 645918 645919 645920 645921 645922 645923 Beta-Oxidation Rate (nmol/min/mg protein) 6.8 4.6 3.3 6.1 2.8 7.1 8.2 7.5 11.1 10.6 9.1 12.3 8.7 8.2 14.3 17.7 17.1 9.3 17.4 20.5 Company Sanitized. Does not contain T S C A CBI 846 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 90-Day Time Point Group I III V VII Animal Number 643241 643300 643143 643205 643235 643173 643290 643272 643292 643228 643250 643243 643311 643318 643247 643194 643252 643260 643315 643215 Beta-Oxidation Rate (nmol/min/mg protein) 6.0 5.8 2.9 6.4 4.6 15.7 9.1 6.7 16.2 17.2 20.8 20.9 18.4 20.9 22.5 32.2 35.7 54.5 51.6 48.5 Company Sanitized. Does not contain T S C A CBI 847 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 36-Day Recovery Time Point Group I VII Animal Number 643237 643226 643195 643246 643253 643225 643296 643258 643316 643220 Beta-Oxidation Rate (nmol/min/mg protein) 12.4 9.1 6.0 9.7 5.5 27.8 26.8 34.5 34.4 26.4 Com pany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 92-Day Recovery Time Point Group I VII Animal Number 643145 643210 643232 643265 643268 643149 643152 643178 643283 643295 Beta-Oxidation Rate (nmol/min/mg protein) 8.7 10.0 7.9 8.6 6.4 32.5 15.8 25.7 25.0 26.7 Company Sanitized. Does no! contain T S C A CBI 849 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 10-Day Time Point Group II IV VI VIII Animal Number 645926 645927 645928 645929 645930 645931 645932 645933 645934 645935 645936 645937 645938 645939 645940 645941 645942 645943 645944 645945 Beta-Oxidation Rate (nmol/min/mg protein) 6.6 7.2 7.7 7.0 12.0 9.9 8.6 4.7 6.0 9.4 13.6 13.4 11.9 17.8 12.3 18.7 21.8 20.9 18.7 25.4 Company Sanitized. Does not contain T S C A CB1 850 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 90-Day Time Point Group II IV VI VIII Animal Number 643477 643374 643406 643486 643361 643390 643396 643380 643433 643389 643322 643489 643409 643366 643367 643341 643370 643446 643435 643466 Beta-Oxidation Rate (nmol/min/mg protein) 5.1 7.1 9.4 7.7 9.9 7.4 12.3 9.0 17.2 15.5 29.3 25.2 32.2 24.4 23.3 39.3 24.5 30.4 32.9 21.4 Company Sanitized. Does not contain T S C A CBI 851 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 36-Day Recovery Time Point Group II VIII Animal Number 643405 643425 643448 643426 643415 643347 643456 643423 643345 645551 Beta-Oxidation Rate (nmol/min/mg protein) 10.5 11.5 9.5 8.4 8.3 18.9 14.8 20.2 21.1 24.6 Com pany Sanitized. Does not contain T S C A H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 92-Day Recovery Time Point Group II VIII Animal Number 643383 643384 643402 643465 643484 643329 643365 643388 643450 643487 Beta-Oxidation Rate (nmol/min/mg protein) 19.2 15.2 19.0 19.3 19.4 35.9 34.3 27.9 31.2 29.1 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS Company Sanitized. Does not contain T S C A CBI 854 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5386 Group : I - 0 mg/kg/day Sex :MALES | ANIMAL 1 FBW BRAIN (Gms) {Gms ) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 512.40 470.00 586.60 601.50 570.80 563.80 622.00 612.90 584.20 575.00 2.079 0.4057 2.080 0.4426 2.155 0.3674 2.165 0.3599 2.089 0.3660 2.142 0.3799 2.223 0.3574 2.145 0.3500 2.121 0.3631 1.982 0.3447 0.053 0.0103 2.5493 0.049 0.0104 2.3558 0.048 0.0082 2.2274 0.061 0.0101 2.8176 0.068 0.0119 3.2551 0.072 0.0128 3.3613 0.047 0.0076 2.1143 0.045 0.0073 2.0979 0.050 0.0086 2.3574 0.061 0.0106 3.0777 Mean S.D. 569.92 2.118 0.3737 46.423 0.065 0.0296 0.055 0.0098 2.6214 0.009 0.0018 0.4747 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.368 0.2670 65.801 1.442 0.3068 69.327 1.793 0.3057 83.202 1.487 0.2472 68.684 1.687 0.2956 80.756 1.698 0.3012 79.272 1.756 0.2823 78.992 1.804 0.2943 84.103 1.545 0.2645 72.843 1.477 0.2569 74.521 1.606 0.2821 75.750 0.160 0.0217 6.4413 HEART (Gms ) %FBW %BRAIN 1.491 0.2910 71.717 1.455 0.3096 69.952 1.804 0.3075 83.712 1.797 0.2988 83.002 1.967 0.3446 94.160 1.764 0.3129 82.353 1.830 0.2942 82.321 1.663 0.2713 77.529 1.701 0.2912 80.198 1.668 0.2901 84.157 1.714 0.3011 80.910 0.155 0.0195 6.8226 KIDNEYS I (Gms) %FBW %BRAIN i 3.529 0.6887 169.75 3.684 0.7838 177.12 4.020 0.6853 186.54 4.200 0.6983 194.00 3.443 0.6032 164.82 4.429 0.7856 206.77 4.172 0.6707 187.67 3.804 0.6207 177.34 3.667 0.6277 172.89 3.765 0.6548 189.96 3.871 0.6819 182.69 0.321 0.0625 12.662 Group : III - 25 mg/kg/day Sex MALES ] ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 504.40 516.40 543.80 677.90 485.90 628.90 518.20 548.90 526.70 611.20 2.042 0.4048 2.086 0.4040 2.110 0.3880 2.319 0.3421 2.147 0.4419 2.312 0.3676 2.123 0.4097 1.986 0.3618 2.278 0.4325 2.210 0.3616 0.064 0.0127 3.1342 0.059 0.0114 2.8284 0.058 0.0107 2.7488 0.065 0.0096 2.8029 0.056 0.0115 2.6083 0.064 0.0102 2.7682 0.072 0.0139 3.3914 0.049 0.0089 2.4673 0,044 0.0084 1.9315 0.070 0.0115 3.1674 Mean S.D. 556.23 2.161 0.3914 62.229 0.115 0.0328 0.060 0.0109 2.7848 0.009 0.0017 0.4083 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.460 0.2895 71.499 1.461 0.2829 70.038 1.332 0.2449 63.128 1.527 0.2253 65.847 1.697 0.3492 79.041 1.771 0.2816 76.600 1.434 0.2767 67.546 1.400 0.2551 70.493 1.499 0.2846 65.803 1.496 0.2448 67.692 1.508 0.2735 69.769 0.133 0.0343 4.9518 (Gms) HEART %FBW %BRAIN 1.536 0.3045 75.220 1.951 0.3778 93.528 1.515 0.2786 71.801 1.955 0.2884 84.304 1.692 0.3482 78.808 1.779 0.2829 76.946 1.545 0.2981 72.774 1.845 0.3361 92.900 1.628 0.3091 71.466 1.665 0.2724 75.339 1.711 0.3096 79.309 0.165 0.0342 8.2378 KIDNEYS | (Gms) %FBW %BRAIN | 3.920 0.7772 191.97 3.892 0.7537 186.58 4.435 0.8156 210.19 4.830 0.7125 208.28 3.761 0.7740 175.17 4.623 0.7351 199.96 3.627 0.6999 170.84 3.968 0.7229 199.80 4.474 0.8494 196.40 4.077 0,6670 184.48 4.161 0.7507 192.37 0.402 0.0550 13.143 FBW - Final Body Weight Company Sanitfeed Does not contain T S C A CBI 855 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : V - 100 mg/kg/day Sex :MALES | ANIMAL I FBW BRAIN {Gms) |(Gms) %FBW 643224 643243 643247 643250 643257 643275 643311 643314 643318 478.10 533.20 544.30 470.60 499.60 532.90 506.70 498.60 567.00 2.080 0.4351 2.065 0.3873 2.054 0.3774 1.991 0.4231 2.076 0.4155 1.948 0.3655 1.999 0.3945 2.191 0.4394 2.239 0.3949 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.049 0.0102 2.3558 0.051 0.0096 2.4697 0.066 0.0121 3.2132 0.041 0.0087 2.0593 0.043 0.0086 2.0713 0.058 0.0109 2.9774 0.045 0.0089 2.2511 0.055 0.0110 2.5103 0.057 0.0101 2.5458 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.517 0.3173 72.933 1.346 0.2524 65.182 1.499 0.2754 72.980 1.382 0.2937 69.412 1.424 0.2850 68.593 1.293 0.2426 66.376 1.523 0.3006 76.188 1.557 0.3123 71.063 1.338 0.2360 59.759 HEART (Gms ) %FBW %BRAIN 1.552 0.3246 74.615 1.473 0.2763 71.332 1.746 0.3208 85.005 1.341 0.2850 67.353 1.423 0.2848 68.545 1.659 0.3113 85.164 1.576 0.3110 78.839 1.413 0.2834 64.491 1.654 0.2917 73.872 Mean S.D. 514.56 2.071 0.4036 31.860 0.093 0.0259 0.052 0.0100 2.4949 0.008 0.0012 0.3873 1.431 0.2795 69.165 0.096 0.0300 4.9268 1.537 0.2988 74.358 0.135 0.0182 7.4153 DuPont-5386 KIDNEYS I (Gms ) %FBW %BRAIN | 3.840 0.8032 184.62 4.361 0.8179 211.19 4.304 0.7907 209.54 4.137 0.8791 207.79 3.672 0.7350 176.88 4.430 0.8313 227.41 4.279 0.8445 214.06 4.203 0.8430 191.83 4.463 0.7871 199.33 4.188 0.8146 202.52 0.268 0.0417 15.841 Group : VII - 250 rog/kg/day Sex MALES | ANIMAL 1 FBW BRAIN (Gms ) (Gms ) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN | 643174 | 643193 | 643194 | 643201 | 643215 | 643252 | 643259 | 643260 | 643298 | 643315 566.60 527.80 510.80 546.00 510.50 498.60 490.10 441.10 516.10 474.80 2.046 0.3611 2.178 0.4127 2.069 0.4051 2.170 0.3974 2.000 0.3918 2.193 0.4398 2.080 0.4244 1.930 0.4375 2.175 0.4214 2.139 0.4505 0.059 0.0104 2.8837 0.055 0.0104 2.5253 0.051 0.0100 2.4650 0.050 0.0092 2.3041 0.057 0.0112 2.8500 0.052 0.0104 2.3712 0.049 0.0100 2.3558 0.040 0.0091 2.0725 0.065 0.0126 2.9885 0.067 0.0141 3.1323 j Mean \ S.D. 508.24 2.098 0.4142 35.490 0.088 0.0266 0.055 0.0107 2.5948 0.008 0.0016 0.3462 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.468 0.2591 71.750 1.422 0.2694 65.289 1.448 0.2835 69.985 1.542 0.2824 71.060 1.686 0.3303 84.300 1.431 0.2870 65.253 1.484 0.3028 71.346 1.271 0.2881 65.855 1.540 0.2984 70.805 1.383 0.2913 64.656 1.468 0.2892 70.030 0.110 0.0193 5.7887 HEART (Gms ) %FBW %BRAIN 1.716 0.3029 83.871 1.440 0.2728 66.116 1.468 0.2874 70.952 1.710 0.3132 78.802 1.421 0.2784 71.050 1.578 0.3165 71.956 1.515 0.3091 72.837 1.352 0.3065 70.052 1.430 0.2771 65.747 1.478 0.3113 69.098 1.511 0.2975 72.048 0.122 0.0168 5.5358 KIDNEYS I (Gms) %FBW %BRAIN | 5.024 0.8867 245.55 4.847 0.9183 222.54 4.156 0.8136 200.87 4.806 0.8802 221.47 5.102 0.9994 255.10 4.572 0.9170 208.48 4.824 0.9843 231.92 3.841 0.8708 199.02 5.006 0.9700 230.16 4.082 0.8597 190.84 4.626 0.9100 220.60 0.445 0.0596 20.883 FBW - Final Body Weight Company San,*. 0oes ^ ^^ )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : I - 0 mg/kg/day Sex :MALES j ANIMAL ! 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Mean S.D. (Gms) LIVER %FBW %BRAIN 12.027 2.3472 578.50 12.058 2.5655 579.71 15.885 2.7080 737.12 17.971 2.9877 830.07 14.869 2.6049 711.78 16.314 2.8936 761.62 19.863 3.1934 893.52 16.844 2.7482 785.27 14.978 2.5638 706.18 15.334 2.6668 773.66 15.614 2.7279 735.74 2.409 0.2426 99.373 SPLEEN (Gms) %FBW %BRAIN 0.763 0.1489 36.700 0.771 0.1640 37.067 0.788 0.1343 36.566 0.857 0.1425 39.584 0.938 0.1643 44.902 1.002 0.1777 46.779 0.969 0.1558 43.590 0.720 0.1175 33.566 0.745 0.1275 35.125 0.703 0.1223 35.469 0.826 0.1455 38.935 0.109 0.0201 4.5784 TESTES THYMUS 1 (Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN j 3.281 0.6403 157.82 3.861 0.8215 185.63 3.654 0.6229 169.56 3.693 0.6140 170.58 3.704 0.6489 177.31 3.624 0.6428 169.19 4.302 0.6916 193.52 3.675 0.5996 171.33 3.307 0.5661 155.92 3.187 0.5543 160.80 0.505 0.0986 24.291 0.390 0.0830 18.750 0.508 0.0866 23.573 0.597 0.0993 27.575 0.352 0.0617 16.850 0.277 0.0491 12.932 0.594 0.0955 26.721 0.512 0.0835 23.869 0.539 0.0923 25.413 0.206 0.0358 10.394 3.629 0.6402 171.16 0.323 0.0754 11.887 0.448 0.0785 21.037 0.135 0.0221 5.9719 Group : III - 25 mg/kg/day Sex MALES 1 ANIMAL 1 (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS ! (Gms ) %FBW %BRAIN 643173 643179 643180 643228 643240 643264 643272 643290 643292 6433 08 14.493 2.8733 709.75 15.519 3.0052 743.96 16.875 3.1032 799.76 20.448 3.0164 881.76 13.780 2.8360 641.83 19.596 3.1159 847.58 15.966 3.0810 752.05 17.459 3.1807 879.10 15.715 2.9837 689.86 18.920 3.0955 856.11 0.510 0.1011 24.976 0.685 0.1326 32.838 0.569 0.1046 26.967 0.779 0.1149 33.592 0.712 0.1465 33.163 1.071 0.1703 46.324 0.769 0.1484 36.222 0.820 0.1494 41.289 0.525 0.0997 23.047 .900 0.1473 40.724 3.142 0.6229 153.87 3.714 0.7192 178.04 3.168 0.5826 150.14 3.651 0.5386 157.44 3.591 0.7390 167.26 3.761 0.5980 162.67 2.928 0.5650 137.92 2.860 0.5210 144.01 3.989 0.7574 175.11 3.165 0.5178 143.21 0.233 0.0462 11.410 0.443 0.0858 21.237 0.307 0.0565 14.550 0.514 0.0758 22.165 0.448 0.0922 20.866 0.281 0.0447 12.154 0.391 0.0755 18.417 0.453 0.0825 22.810 0.251 0.0477 11.018 0.408 0.0668 18.462 Mean S.D. 16.877 3.0291 780.18 2.210 0.1093 85.088 0.734 0.1315 33.914 0.175 0.0248 7.5143 3.397 0.6162 156.97 0.389 0.0910 13.696 0.373 0.0674 17.309 0.098 0.0176 4.6311 ! DuPont-5386 FBW - Final Body Weight Company Sanitized. Does not contain T S C CB1 857 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : V - 100 mg/kg/day Sex :MALES 1 ANIMAL 1 643224 643243 643247 64325.0 643257 643275 643311 643314 64331.8 LIVER (Gms ) %F8W %BRAIN 18.368 3.8419 883.08 23.501 4.4075 1138.1 23.174 4.2576 1128.2 17.434 3.7046 875.64 19.589 3.9209 943.59 22.561 4.2336 1158.2 22.345 4.4099 1117.8 20.904 4.1925 954.08 21.877 3.8584 977.09 SPLEEN TESTES (Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 0.687 0.1437 33.029 0.843 0.1581 40.823 0.919 0.1688 44.742 0.677 0.1439 34.003 0.754 0.1509 36.320 0.743 0.1394 38.142 0.887 0.1751 44.372 0.857 0.1719 39.115 0.818 0.1443 36.534 3.605 0.7540 173.32 3.331 0.6247 161.31 3.793 0.6969 184.66 3.386 0.7195 170.07 3.497 0.7000 168.45 3.526 0.6617 181.01 3.499 0.6905 175.04 3.653 0.7327 166.73 3.693 0.6513 164.94 THYMUS 1 (Gms) %FBW %BRAIN 1 0.242 0.0506 11.635 0.500 0.0938 24.213 0.429 0.0788 20.886 0.367 0.0780 18.433 0.383 0.0767 18.449 0.309 0.0580 15.862 0.443 0.0874 22.161 0.217 0.0435 9.9042 0.459 0.0810 20.500 Mean S.D. 21.084 4.0919 1019.5 2.167 0.2633 115.06 0.798 0.1551 38.564 0.087 0.0138 4.1546 3.554 0.6924 171.72 0.147 0.0410 7.5837 0.372 0.0720 18.005 0.098 0.0172 4.7634 Group : VII - 250 mg/kg/day Sex MALES 1 ANIMAL 1 (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS 1 (Gms) %FBW %BRAIN 1 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 28.144 4.9672 1375.6 24.347 4.6129 1117.9 24.229 4.7433 1171.0 26.508 4.8549 1221.6 27.373 5.3620 1368.7 27.181 5.4515 1239.4 25.986 5.3022 1249.3 23.001 5.2145 1191.8 26.542 5.1428 1220.3 22.063 4.6468 1031.5 0.737 0.1301 36.022 0.627 0.1188 28.788 0.698 0.1366 33.736 0.884 0.1619 40.737 0.691 0.1354 34.550 0.705 0.1414 32.148 0.616 0.1257 29.615 0.683 0.1548 35.389 0.790 0.1531 36.322 0.703 0.1481 32.866 3.576 0.6311 174.78 3.692 0.6995 169.51 3.386 0.6629 163.65 3 975 0.7280 183 18 3.517 0.6889 175.85 3.522 0.7064 160.60 3.709 0.7568 178.32 3.021 0.6849 156.53 3.925 0.7605 180.46 3.168 0.6672 148.11 NW 0.392 0.0743 17.998 0.463 0.0906 22.378 0.455 0.0833 20.968 0.331 0.0648 16.550 0.270 0.0542 12.312 0.445 0.0908 21.394 0.310 0.0703 16.062 0.295 0.0572 13.563 0.276 0.0581 12.903 Mean S.D. 25.537 5.0298 1218.7 2.018 0.3066 103.65 0.713 0.1406 34.017 0.078 0.0138 3.4685 3.549 0.6986 169.10 0.302 0.0411 11.503 0.360 0.0715 17.125 0.080 0.0142 3.8158 DuPont-5386 FBW - Final Body Weight Company Sanitized. Does not contain T S C A CBI )1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : I - 0 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW BRAIN (Gms) (Gms ) %FBW 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 419.20 648.90 597.40 590.10 516.00 677.20 635.30 650.30 656.10 516.00 2.104 0.5019 2.210 0.3406 2.204 0.3689 2.082 0.3528 1.996 0.3868 2.216 0.3272 2.066 0.3252 2.369 0.3643 2.158 0.3289 2.105 0.4079 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0126 2.5190 0.062 0.0096 2.8054 0.056 0.0094 2.5408 0.046 0.0078 2.2094 0.039 0.0076 1.9539 0.065 0.0096 2.9332 0.053 0.0083 2.5653 0.068 0.0105 2.8704 0.046 0.0070 2.1316 0.062 0.0120 2.9454 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.332 0.3177 63.308 1.617 0.2492 73.167 1.551 0.2596 70.372 1.204 0.2040 57.829 1.539 0.2983 77.104 1.843 0.2722 83.168 1.171 0.1843 56.680 1.506 0.2316 63.571 1.683 0.2565 77.989 1.659 0.3215 78.812 (Gms) HEART %FBW %BRAIN 1.463 0.3490 69.534 1.749 0.2695 79.140 1.986 0.3324 90.109 1.592 0.2698 76.465 2.236 0.4333 112.02 1.803 0.2662 81.363 1.787 0.2813 86.496 1.950 0.2999 82.313 1.756 0.2676 81.372 1.547 0.2998 73.492 Mean S.D. 590.65 2.151 0.3705 82.533 0.105 0.0536 0.055 0.0094 2.5475 0.009 0.0019 0.3526 1.511 0.2595 70.200 0.215 0.0454 9.3499 1.787 0.3069 83.231 0.229 0.0528 11.737 KIDNEYS (Gms) %FBW %BRAIN 3.616 0.8626 171.86 4.075 0.6280 184.39 3.509 0.5874 159.21 3.752 0.6358 180.21 3.582 0.6942 179.46 4.190 0.6187 189.08 4.268 0.6718 206.58 4.300 0.6612 181.51 4.642 0.7075 215.11 3.284 0.6364 156.01 3.922 0.6704 182.34 0.434 0.0765 18.447 Group : VII - 250 mg/kg/day Sex MALES 1 ANIMAL 1 FBW (Gms) 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 472.60 533.80 490.80 558.10 541.30 542.00 515.70 562.60 602.20 560.70 BRAIN (Gms} %FBW 2.188 0.4630 2.081 0.3898 2.048 0.4173 2.154 0.3860 2.208 0.4079 2.101 0.3876 2.230 0.4324 2.202 0.3914 2.175 0.3612 2.096 G .3738 ADRENAL GLANDS (Gms) %FBW %BRA IN 0.051 0.0108 2.3309 0.054 0.0101 2.5949 0.054 0.0110 2.6367 0.035 0.0063 1.6249 0.060 0.0111 2.7174 0.061 0.0113 2.9034 0.053 0.0103 2.3767 0.052 0.0092 2.3615 0.062 0.0103 2.8506 0.057 0.0102 2.7195 Mean S.D. 537.98 2.148 0.4010 37.554 0.062 0.0300 0.054 0.0101 2.5116 0.008 0.0015 0.3706 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.592 0.3369 72.761 1.555 0.2913 74.724 0.998 0.2033 48.730 5.417 0.9706 251.49 1.551 0.2865 70.245 1.563 0.2884 74.393 1.296 0.2513 58.117 1.812 0.3221 82.289 1.519 0.2522 69.839 1.683 0.3002 80.296 1.899 0.3503 88.288 1.256 0.2213 58.207 HEART (Gms) %FBW %BRAIN 1.507 0.3189 68.876 1.830 0.3428 87.938 1.671 0.3405 81.592 1.751 0.3137 81.291 1.734 0.3203 78.533 1.696 0.3129 80.723 1.622 0.3145 72.735 1.690 0.3004 76.748 1.713 0.2845 78.759 1.817 0.3241 86.689 1.703 0.3173 79.388 0.094 0.0172 5.7690 KIDNEYS (Gms) %FBW %BRAIN 4.220 0.8929 192.87 4 466 0.8366 214.61 3.747 0.7634 182.96 5.110 0.9156 237.23 4.870 0.8997 220.56 4.634 0.8550 220.56 3.869 0.7502 173.50 4.715 0.8381 214.12 4.923 0.8175 226.34 4.706 0.8393 224.52 4.526 0.8408 210.73 0.451 0.0545 20.637 FBW - Final Body Weight Company Sanitized. Does not contain T S C A CBt 859 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : I - 0 mg/kg/day Sex :MALES 1 ANIMAL 1 (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS 1 (Gms) %FBW %BRAIN 1 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 10.852 2.5887 515.78 16.681 2.5707 754.80 15.905 2.6624 721.64 14.428 2.4450 692.99 15.272 2.9597 765.13 17.881 2.6404 806.90 16.290 2.5641 788.48 16.405 2.5227 692.49 16.410 2.5011 760.43 12.941 2.5079 614.77 0.462 0.1102 21.958 0.800 0.1233 36.199 0.728 0.1219 33.031 0.841 0.1425 40.394 0.819 0.1587 41.032 1.063 0.1570 47.969 0.897 0.1412 43.417 0.770 0.1184 32.503 0.738 0.1125 34.198 0.788 0.1527 37.435 3.272 0.7805 155.51 3.515 0.5417 159.05 3.395 0.5683 154.04 2.870 0.4864 137.85 3.690 0.7151 184.87 4.391 0.6484 198.15 3.141 0.4944 152.03 3.762 0.5785 158.80 2.994 0.4563 138.74 3.009 0.5831 142.95 0.277 0.0661 13.165 0.502 0.0774 22.715 0.367 0.0614 16.652 0.247 0.0419 11.864 0.204 0.0395 10.220 0.283 0.0418 12.771 0.253 0.0398 12.246 0.371 0.0571 15.661 0.373 0.0569 17.285 0.160 0.0310 7.6009 Mean S.D. 15.307 2.5963 711.34 2.068 0.1435 88.595 0.791 0.1338 36.814 0.151 0.0187 7.1480 3.404 0.5853 158.20 0.459 0.1032 19.427 0.304 0.0513 14.018 0.100 0.0146 4.2375 Group : VII - 250 mg/kg/day Sex MALES 1 ANIMAL ! (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms ) %FBW %BRAIN THYMUS 1 (Gms) %FBW %BRAIN 1 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 15.674 3.3165 716.36 18.089 3.3887 869.25 15.720 3.2029 767.58 20.721 3.7128 961.98 20.334 3.7565 920.92 19.595 3.6153 932.65 16.997 3.2959 762.20 18.904 3.3601 858.49 20.729 3.4422 953.06 23.195 4.1368 1106.6 0.893 0.1890 40.814 0.763 0.1429 36.665 0.820 0.1671 40.039 1.063 0.1905 49.350 0.873 0.1613 39.538 0.722 0.1332 34.365 0.706 0.1369 31.659 0.664 0.1180 30.154 0.815 0.1353 37.471 0.956 0.1705 45.611 3.897 0.8246 178.11 3.749 0.7023 180.15 1.983 0.4040 96.826 3.798 0.6805 176.32 3.434 0.6344 155.53 3.553 0.6555 169.11 3.002 0.5821 134.62 3.636 0.6463 165.12 3.027 0.5027 139.17 3.457 0.6166 164.93 0.226 0.0478 10.329 0.219 0.0410 10.524 0.346 0.0705 16.895 0.318 0.0570 14.763 0.344 0.0636 15.580 0.139 0.0256 6.6159 0.372 0.0721 16.682 0.271 0.0482 12.307 0.317 0.0526 14.575 0.398 0.0710 18.989 Mean S.D. 18.996 3.5228 884.91 2.412 0.2835 116.19 0.828 0.1545 38.567 0.123 0.0248 5.9162 3.354 0.6249 155.99 0.567 0.1136 25.953 0.295 0.0549 13.726 0.080 0.0150 3.7426 FBW - Final Body Weight ) DuPont-5386 Company Sanitized. Does not contain T S C A C B I 860 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : I - 0 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW KIDNEYS (Gms ) (Gms) %FBW LIVER (Gms) %FBW TESTES (Gms) %FBW THYROID GLAND (Gms) %FBW 543145 643210 643232 643265 643268 557.80 606.20 617.50 576.90 687.80 3.665 0.6570 4.696 0.7747 4.159 0.6735 4.148 0.7190 4.453 0.6474 15.836 2.8390 16.402 2.7057 16.538 2.6782 16.530 2.8653 19.012 2.7642 3.207 0.5749 4.177 0.6890 3.512 0.5687 3.643 0.6315 4.148 0.6031 0.023 0.0041 0.022 0.0036 0.026 0.0042 0.029 0.0050 0.023 0.0033 Mean S .D. 609.24 49.853 4.224 0.6943 0.387 0.0526 16.864 2.7705 1.235 0.0813 3.737 0.6135 0.419 0.0491 0.025 0.0041 0.003 0.0006 Group : III - 25 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) 1 643202 643293 1 643305 1 643306 1 643310 523.60 620.20 644.70 514.80 618.70 KIDNEYS (Gms) %FBW 4.108 0.7846 4.571 0.7370 4.531 0.7028 3.090 0.6002 4.329 0.6997 1 Mean I S.D. 584.40 60.488 4.126 0.7049 0.608 0.0678 LIVER (Gms) %FBW 14.756 2.8182 15.455 2.4919 16.640 2.5810 13.123 2.5491 14.482 2.3407 14.891 2.5562 1.293 0.1731 TESTES (Gms) %FBW 4.385 0.8375 3.564 0.5747 3.967 0.6153 3.244 0.6301 3.412 0.5515 3.714 0.6418 0.461 0.1138 THYROID GLAND (Gms) %FBW 0.018 0.0034 0.026 0.0042 0.023 0.0036 0.015 0.0029 0.024 0.0039 0.021 0.0036 0.005 0.0005 | | | | DuPont-5386 FBW - Final Body Weight Com pany Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : V - 100 mg/kg/day Sex :MALES 1 ANIMAL 1 643159 643169 643181 643206 643286 FBW (Gms) 608.80 555.30 729.90 534.30 558.50 KIDNEYS (Gms) %FBW 4.267 0.7009 4.278 0.7704 4.386 0.6009 4.186 0.7835 3.895 0.6974 Mean S .D ,, 597.36 78.983 4.202 0.7106 0.186 0.0728 LIVER i(Gms) %FBW 18.278 3.0023 15.727 2.8322 19.257 2.6383 17.415 3.2594 15.356 2.7495 17.207 2.8963 1.659 0.2425 TESTES (Gms) %FBW 4.082 0.6705 3.187 0.5739 4.697 0.6435 3.756 0.7030 3.081 0.5517 3.761 0.6285 0.665 0.0641 THYROID GLAND (Gms) %FBW 0.022 0.0036 0.026 0.0047 0.019 0.0026 0.028 0.0052 0.029 0.0052 0.025 0.0043 0.004 0.0011 Group : VII - 250 mg/kg/day Sex :MALES 1 ANIMAL ! FBW (Gms) 643149 643152 643178 643283 643295 619.10 770.50 457.70 575.20 522.50 KIDNEYS (Gms) %FBW 4.260 0.6881 5.835 0.7573 4.031 0.8807 4.092 0.7114 4.236 0.8107 Mean S.D. 589 00 118.00 4.491 0.7696 0.758 0.0778 LIVER (Gms) %FBW 20.372 3.2906 23.913 3.1036 14.293 3.1228 18.797 3.2679 15.313 2.9307 18.538 3.1431 3.897 0.1453 TESTES (Gms) %FBW 3.958 0.6393 4.128 0.5358 3.183 0.6954 3.459 0.6014 3.805 0.7282 3.707 0.6400 0.383 0.0762 THYROID GLAND (Gms) %FBW 0.021 0.0034 0.026 0.0034 0.020 0.0044 0.023 0.0040 0.028 0.0054 0.024 0.0041 0.003 0.0008 | | | j DuPont-5386 FBW - Final Body Weight Company Sanitized. Does not contain T S C A CBI 862 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN KIDNEYS (Gms) %FBW %BRAIN 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 280.00 373.00 303.50 301.20 290.20 260.40 304.20 331.30 285.40 245.30 1.777 0.6346 1.911 0.5123 1.906 0.6280 1.799 0.5973 2.032 0.7002 1.871 0.7185 1.811 0.5953 1.946 0.5874 1.871 0.6556 1.915 0.7807 0.061 0.0218 3.4328 0.080 0.0214 4.1863 0.056 0.0185 2.9381 0.055 0.0183 3.0573 0.079 0.0272 3.8878 0.055 0.0211 2.9396 0.065 0.0214 3.5892 0.079 0.0238 4.0596 0.062 0.0217 3.3137 0.057 0.0232 2.9765 0.865 0.3089 48.678 1.137 0.3048 59.498 1.085 0.3575 56.925 1.036 0.3440 57.588 1.103 0.3801 54.281 0.887 0.3406 47.408 1.033 0.3396 57.040 1.098 0.3314 56.423 0.960 0.3364 51.309 0.831 0.3388 43.394 2.005 0.7161 112.83 2.400 0.6434 125.59 1.979 0.6521 103.83 2.068 0.6866 114.95 2.107 0.7261 103.69 1.778 0.6828 95.029 2.098 0.6897 115.85 2.342 0.7069 120.35 2.171 0.7607 116.03 1.740 0.7093 90.862 Mean S.D. 297.45 1.884 0.6410 35.815 0.076 0.0766 0.065 0.0218 3.4381 0.010 0.0026 0.4765 1.004 0.3382 53.255 0.110 0.0216 5.2999 2.069 0.6974 109.90 0.211 0.0346 11.163 LIVER 1 (Gms) %FBW %BRAIN j 7.697 2.7489 433.15 9.431 2.5284 493.51 8.409 2.7707 441.19 9.159 3.0408 509.12 8.431 2.9052 414.91 7.670 2.9455 409.94 9.145 3.0062 504.97 9.612 2.9013 493.94 7.794 2.7309 416.57 6.941 2.8296 362.45 8.429 2.8408 447.97 0.893 0.1525 49.753 Group : IV - 25 mg/kg/day Sex :FEMALES j ANIMAL ! FBW (Gms) 643324 643364 643380 643389 643390 643396 643410 643433 643458 290.60 288.70 321.10 280.50 274.30 340.40 312.50 337.10 287.80 BRAIN (Gms) %FBW 2.136 0.7350 1.848 0.6401 2.078 0.6472 2.061 0.7348 1.934 0.7051 1.989 0.5843 2.039 0.6525 1.829 0.5426 1.953 0.6786 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.057 0.0196 2.6685 0.070 0.0242 3.7879 0.061 0.0190 2.9355 0.073 0.0260 3.5420 0.060 0.0219 3.1024 0.085 0.0250 4.2735 0.065 0.0208 3.1878 0.057 0.0169 3.1165 0.063 0.0219 3.2258 Mean S.D. 303.67 1.985 0.6578 24.735 0.104 0.0649 0.066 0.0217 3.3155 0.009 0.0030 0.4828 (Gms) HEART %FBW %BRAIN 1.047 0.3603 49.017 0.883 0.3059 47.781 1.058 0.3295 50.914 1.062 0.3786 51.528 1.088 0.3966 56.256 1.276 0.3749 64.153 1.069 0.3421 52.428 1.716 0.5090 93.822 1.048 0.3641 53.661 1.139 0.3734 57.729 0.238 0.0578 14.364 KIDNEYS (Gms) %FBW %BRAIN 2.267 0.7801 106.13 1.828 0.6332 98.918 2.513 0.7826 120.93 2.315 0.8253 112.32 2.276 0.8297 117.68 2.758 0.8102 138.66 2.639 0.8445 129.43 2.058 0.6105 112.52 2.439 0.8475 124.88 2.344 0.7737 117.94 0.286 0.0895 12.149 LIVER | (Gms) %FBW %BRAIN | 8.814 3.0330 412.64 8.713 3.0180 471.48 9.167 2.8549 441.15 9.652 3.4410 468.32 8.436 3.0755 436.19 12.620 3.7074 634.49 8.619 2.7581 422.71 8.877 2.6333 485.35 8.711 3.0268 446.03 9.290 3.0609 468.71 1.298 0.3323 66.482 FBW - Final Body Weight Company Sanitized. Does not contain T S C A CBI 863 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VI - 100 mg/kg/day Sex FEMALES 1 ANIMAL 1 FBW (Gms) 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 282.00 270.40 303.80 289.50 259.00 272.30 313.20 311.80 254.60 307.50 BRAIN (Gms) %FBW 1.887 0.6691 1.936 0.7160 1.977 0.6508 1.919 0.6629 1.895 0.7317 1.877 0.6893 1.982 0.6328 1.918 0.6151 1.716 0.6740 2.035 0.6618 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0188 2.8087 0.080 0.0296 4.1322 0.063 0.0207 3.1866 0.074 0.0256 3.8562 0.070 0.0270 3.6939 0.049 0.0180 2.6105 0-072 0.0230 3.6327 0.065 0.0208 3.3889 0.069 0.0271 4.0210 0.060 0.0195 2.9484 HEART (Gms ) %FBW %BRAIN 1.035 0.3670 54.849 1.015 0.3754 52.428 0.995 0.3275 50.329 1.046 0.3613 54.508 0.894 0.3452 47.177 1.031 0.3786 54.928 1.094 0.3493 55.197 1.058 0.3393 55.162 0.919 0.3610 53.555 1.031 0.3353 50.663 KIDNEYS (Gms) %FBW %BRAIN 2.257 0.8004 119.61 2.321 0.8584 119.89 2.226 0.7327 112.59 2.348 0.8111 122.36 2.008 0.7753 105.96 2.250 0.8263 119.87 2.782 0.8883 140.36 2.603 0.8348 135.71 2.136 0.8390 124.48 2.359 0.7672 115.92 Mean S.D. 286.41 1.914 0.6703 22.003 0.085 0.0353 0.066 0.0230 3.4279 0.010 0.0041 0.5255 1.012 0.3540 52.879 0.062 0.0173 2.7060 2.329 0.8133 121.68 0.222 0.0462 10.153 (Gms) LIVER 1 %FBW %BRAIN 1 10.226 3.6262 541.92 9.397 3.4752 485.38 10.124 3.3325 512.09 10.624 3.6698 553.62 8.750 3.3784 461.74 10.217 3.7521 544.33 11.802 3.7682 595.46 11.178 3.5850 582.79 9.439 3.7074 550.06 11.184 3.6371 549.58 10.294 3.5932 537.70 0.938 0.1513 41.017 Group : VIII - 250 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW j BRAIN J ADRENAL GLANDS j 1 ! (Gms) 1(Gms) %FBW j (Gms) %FBW %BRAIN | (Gms) HEART J KIDNEYS 1 %FBW %BRAIN 1 (Gms) %FBW %BRAIN | (Gms) LIVER j %FBW %BRAIN j 643332 643341 643359 643370 643404 643408 643435 643446 643466 263.50 287.20 335.10 317.30 249.30 290.10 233.90 295.80 279.20 1.904 0.7226 1.888 0.6574 1.978 0.5903 1.930 0.6083 2.026 0.8127 1.859 0.6408 1.797 0.7683 2.001 0.6765 2.111 0.7561 0.064 0.0243 3.3613 0.061 0.0212 3.2309 0.071 0.0212 3.5895 0.071 0.0224 3.6788 0.078 0.0313 3.8500 0.051 0.0176 2.7434 0.064 0.0274 3.5615 0.060 0.0203 2.9985 0.073 0.0261 3.4581 1.000 0.3795 52.521 0.885 0.3081 46.875 1.193 0.3560 60.313 1.089 0.3432 56.425 1.017 0.4079 50.197 1.016 0.3502 54.653 0.877 0.3749 48.804 1.059 0.3580 52.924 1.130 0.4047 53.529 2.313 0.8778 121.48 2.474 0.8614 131.04 2.878 0.8588 145.50 2.689 0.8475 139.33 3.075 1.2335 151.78 2.404 0.8287 129.32 2.329 0.9957 129.60 2.736 0.9249 136.73 2.550 0.9133 120.80 12.742 4.8357 669.22 12.486 4.3475 661.33 14.952 4.4620 755.92 14.597 4.6004 756.32 12.396 4.9723 611.85 11.243 3.8756 604.79 10.064 4.3027 560.04 12.746 4.3090 636.98 12.022 4.3059 569.49 ] Mean 1 S.D. 283.49 1.944 0.6925 31.745 0.095 0.0765 0.066 0.0235 3.3858 0.008 0.0042 0.3475 1.030 0.3647 52.916 0.104 0.0312 4.0525 2.605 0.9269 133.95 12.583 4.4457 647.33 0.260 0.1256 10.399 1.509 0.3254 71.762 FBW - Final Body Weight Company Sanitized. Does not contain T S C A H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL OVARIES (Gms) %FBW %BRAIN SPLEEN THYMUS (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN UTERUS [ (Gms) %FBW %BRAIN | 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 0.133 0.0475 7.4845 0.127 0.0340 6.6457 0.117 0.0386 6.1385 0.071 0.0236 3.9466 0.157 0.0541 7.7264 0.118 0.0453 6.3068 0.141 0.0464 7.7858 0.132 0.0398 6.7831 0.076 0.0266 4.0620 0.083 0.0338 4.3342 0.534 0.1907 30.051 0.640 0.1716 33.490 0.515 0.1697 27.020 0.557 0.1849 30.962 0.605 0.2085 29.774 0.457 0.1755 24.425 0.384 0.1262 21.204 0.611 0.1844 31.398 0.421 0.1475 22.501 0.336 0.1370 17.546 0.188 0.0671 10.580 0.511 0.1370 26.740 0.398 0.1311 20.881 0.333 0.1106 18.510 0.329 0.1134 16.191 0.243 0.0933 12.988 0.256 0.0842 14.136 0.256 0.0773 13.155 0.320 0.1121 17.103 0.144 0.0587 7.5196 0.484 0.1729 27.237 0.634 0.1700 33.176 0.514 0.1694 26.967 0.675 0.2241 37.521 0.516 0.1778 25.394 0.570 0.2189 30.465 0.588 0.1933 32.468 0.557 0.1681 28.623 0.551 0.1931 29.449 0.693 0.2825 36.188 Mean S.D. 0.116 0.0390 6.1214 0.029 0.0096 1.4950 0.506 0.1696 26.837 0.103 0.0256 5.2041 0.298 0.0985 15.780 0.106 0.0266 5.4588 0.578 0.1970 30.749 0.070 0.0363 4.0262 Group : IV - 25 mg/kg/day Sex :FEMALES 1 ANIMAL ! 643324 643364 643380 643389 643390 643396 643410 643433 643458 OVARIES (Gms) %FBW %BRAIN 0.118 0.0406 5.5243 0.105 0.0364 5.6818 0.146 0.0455 7.0260 0.135 0.0481 6.5502 0.109 0.0397 5.6360 0.098 0.0288 4.9271 0.151 0.0483 7.4056 0.117 0.0347 6.3969 0.120 0.0417 6.1444 SPLEEN (Gms) %FBW %BRAIN 0.537 0.1848 25.140 0.496 0.1718 26.840 0.473 0.1473 22.762 0.493 0.1758 23.920 0.445 0.1622 23.009 0.615 0.1807 30.920 0.565 0.1808 27.710 0.486 0.1442 26.572 0.445 0.1546 22.785 THYMUS (Gms) %FBW %BRAIN 0.269 0.0926 12.594 0.171 0.0592 9.2532 0.347 0.1081 16.699 0.306 0.1091 14.847 0.309 0.1127 15.977 0.231 0.0679 11.614 0.388 0.1242 19.029 0.441 0.1308 24.112 0.348 0.1209 17.819 UTERUS | (Gms) %FBW %BRAIN | 0.959 0.3300 44.897 0.503 0.1742 27.219 0.549 0.1710 26.420 0.413 0.1472 20.039 0.929 0.3387 48.035 0.653 0.1918 32.831 0.978 0.3130 47.965 0.454 0.1347 24.822 0.513 0.1782 26.267 Mean S.D. 0.122 0.0404 6.1436 0.018 0.0065 0.7854 0.506 0.1669 25.518 0.056 0.0153 2.7589 0.312 0.1028 15.771 0.082 0.0249 4.4157 0.661 0.2199 33.166 0.230 0.0825 10.887 DuPont-5386 FBW - Final Body Weight Company Sanitized. Does not contain T S C A CB 1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VI - 100 mg/kg/day Sex :FEMALES 1 ANIMAL 1 (Gms) OVARIES %FBW %BRAIN SPLEEN (Gms) % FBW % BRAIN THYMUS UTERUS 1 (Gms) % F B W %B R A I N 1(Gms) % FBW % B R A I N 1 1 643322 1 643323 ! 643366 i 643367 1 643392 1 643409 j 643461 1 643462 1 643472 i 643489 j 1 Mean S.D. 0.113 0.149 0.157 0.103 0.128 0.133 0.150 0.120 0.121 0.113 Q .0401 0.0551 0.0517 0.0356 0.0494 0.0488 0.0479 0.0385 0.0475 0.0367 5.9883 7.6963 7.9413 5.3674 6.7546 7.0858 7.5681 6.2565 7.0513 5.5528 0.129 0.0451 6.7262 0.018 0.0068 0.9037 0.436 0.662 0.507 0.427 0.398 0.423 0.642 0.652 0.445 0.479 0.1546 0.2448 0.1669 0.1475 0.1537 0.1553 Q .2050 0.2091 0.1748 0.1558 23.105 34.194 25.645 22.251 21.003 22.536 32.392 33.994 25.932 23.538 0.507 0.1767 26.459 0.104 0.0322 5.1141 0.344 0.288 0.249 0.395 0.201 0.329 0.304 0.314 0.211 0.215 0.1220 0.1065 0.0820 0.1364 0.0776 0.1208 0.0971 0.1007 0.0829 0.0699 18.230 14.876 12.595 20.584 10.607 17.528 15.338 16.371 12.296 10.565 0.285 0.0996 14.899 0.065 0.0219 3.3660 0.539 0.743 0.604 0.647 0.498 0.386 0.639 0.657 0.603 0.491 0.1911 0.2748 0.1988 0.2235 0.1923 0.1418 0.2040 0.2107 0.2368 0.1597 28.564 38.378 30.551 33.715 26.280 20.565 32.240 34.254 35.140 24.128 0.581 0.2034 30.382 0.103 0.0375 5.4954 G r o u p : V III - 250 mg/kg/day Sex :FEMALES 1 ANIMAL 1 643332 643341 643359 643370 643404 643408 643435 643446 643466 OVARIES (Gms) % FBW % B R A I N 0.102 0.103 0.140 0.093 0.139 0.117 0.103 0.104 0.100 0.0387 0.0359 0.0418 0.0293 0.0558 0.0403 0.0440 0.0352 0.0358 5.3571 5.4555 7.0779 4.8187 6.8608 6.2937 5.7318 5.1974 4.7371 SPLEEN (Gms) % F B W %B R A I N 0.424 0.424 0.645 0.540 0.528 0.555 0.470 0.617 0.528 0.1609 0.1476 0.1925 0.1702 0.2118 0.1913 0.2009 0.2086 0.1891 22.269 22.458 32.609 27.979 26.061 29.855 26.155 30.835 25.012 THYMUS (Gms ) %FBW %BRAIN 0.209 0.258 0.505 0.284 0.221 0.302 0.298 0.202 0.281 0.0793 0.0898 0.1507 0.0895 0.0886 0.1041 0.1274 0.0683 0.1006 10.977 13.665 25.531 14.715 10.908 16.245 16.583 10.095 13.311 UTERUS 1 (Gms) % FBW % B R A I N 1 0.917 0.850 0.702 0.429 0.367 0.486 0.828 0.656 0.745 0.3480 0.2960 0.2095 0.1352 0.1472 0.1675 0.3540 0.2218 0.2668 48.162 45.021 35.490 22.228 18.115 26.143 46.077 32.784 35.291 Mean S.D. 0.111 0.0396 5.7256 0.017 0.0074 0.8461 0.526 0.1859 27.026 0.077 0.0219 3.6026 0.284 0.0998 14.670 0.091 0.0253 4.6861 0.664 0.2384 34.368 0.196 0.0826 10.751 ) DuPont-5386 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI 866 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES ANIMAL FBW BRAIN (Giusl (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN KIDNEYS (Gms) %FBW %BRAIN 643330 643377 643387 643405 643415 643425 643426 643448 643453 278.80 356.00 334.20 375.20 414.90 365.00 376.00 329.20 348.70 1.784 0.6399 1.893 0.5317 2.004 0.5996 1.915 0.5104 1.940 0.4676 1.982 0.5430 1.870 0.4973 2.009 0.6103 1.955 0.5607 0.053 0.0190 2.9709 0.066 0.0185 3.4865 0.077 0.0230 3.8423 0.085 0.0227 4.4386 0.087 0.0210 4.4845 0.055 0.0151 2.7750 0.055 0.0146 2.9412 0.062 0.0188 3.0861 0.059 0.0169 3.0179 1.207 0.4329 67.657 1.151 0.3233 60.803 1.125 0.3366 56.138 1.117 0.2977 58.329 1.331 0.3208 68.608 1.202 0.3293 60.646 1.331 0.3540 71.176 1.026 0.3117 51.070 1.079 0.3094 55.192 2.209 0.7923 123.82 2.706 0.7601 142.95 2.396 0.7169 119.56 2.264 0.6034 118.22 2.843 0.6852 146.55 2.429 0.6655 122.55 2.243 0.5965 119.95 2.187 0.6643 108.86 2.654 0.7611 135.75 Mean S.D. 353.11 1.928 0.5512 37.832 0.072 0.0568 0.067 0.0189 3.4492 0.013 0.0030 0.6582 1.174 0.3351 61.069 0.105 0.0402 6.7915 2.437 0.6939 126.47 0.242 0.0694 12.508 DuPont-5386 LIVER (Gms ) %FBW %BRA IN 8.689 3.1166 487.05 11.099 3.1177 586.32 8.682 2.5978 433.23 10.447 2.7844 545.54 13.441 3.2396 692.84 9.244 2.5326 466.40 10.833 2.8811 579.30 7.944 2.4131 395.42 10.507 3.0132 537.44 10.098 2.8551 524.84 1.672 0.2918 90.512 Group : VIII - 250 mg/kg/day Sex :FEMALES ANIMAL I FBW BRAIN (Gms) (Gms ) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 313.00 263.40 286.30 352.20 294.70 365.40 312.70 326.60 272.00 299.50 1.892 0.6045 1.839 0.6982 1.853 0.6472 1.782 0.5060 1.932 0.6556 1.891 0.5175 2.024 0.6473 2.114 0.6473 1.879 0.6908 1.912 0.6384 0.091 0.0291 4.8097 0.074 0.0281 4.0239 0.075 0.0262 4.0475 0.065 0.0185 3.6476 0.094 0.0319 4.8654 0.061 0.0167 3.2258 0.072 0.0230 3.5573 0.075 0.0230 3.5478 0.069 0.0254 3.6722 0.068 0.0227 3.5565 Mean S.D. 308.58 32.733 1.912 0.6253 0.095 0.0653 0.074 0.0244 3.8954 0.011 0.0047 0.5504 (Gms) HEART %FBW %BRAIN 1.145 0.3658 60.518 0.948 0.3599 51.550 1.028 0.3591 55.478 1.111 0.3154 62.346 1.165 0.3953 60.300 1.058 0.2895 55.949 1.209 0.3866 59.733 1.122 0.3435 53.075 1.090 0.4007 58.010 0.951 0.3175 49.738 1.083 0.3534 56.670 0.087 0.0369 4.2230 KIDNEYS (Gms) %FBW %BRAIN 2.393 0.7645 126.48 2.320 0.8808 126.16 2.282 0.7971 123.15 2.222 0.6309 124.69 2.311 0.7842 119.62 2.699 0.7386 142.73 3.458 1.1059 170.85 2.888 0.8843 136.61 2.092 0.7691 111.34 2.408 0.8040 125.94 2.507 0.8159 130.76 0.406 0.1245 16.478 (Gms) LIVER %FBW %BRAIN 9.195 2.9377 485.99 8.942 3.3948 486.24 8.176 2.8557 441.23 10.438 2.9637 585.75 11.520 3.9091 596.27 10.501 2.8738 555.31 11.910 3.8088 588.44 11.658 3.5695 551.47 8.467 3.1129 450.61 9.126 3.0471 477.30 9.993 3.2473 521.86 1.389 0.3953 59.782 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI 867 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL ! 643330 643377 643387 643405 643415 643425 643426 643448 643453 OVARIES (Gms) %FBW %BRAIN 0.067 0.0240 3.7556 0.078 0.0219 4.1204 0.127 0.0380 6.3373 0.134 0.0357 6.9974 0.108 0.0260 5.5670 0.127 0.0348 6.4077 0.100 0.0266 5.3476 0.148 0.0450 7.3668 0.150 0.0430 7.6726 SPLEEN (Gms) %FBW %BRAIN 0.575 0.2062 32.231 0.581 0.1632 30.692 0.474 0.1418 23.653 0.744 0.1983 38.851 0.608 0.1465 31.340 0.460 0.1260 23.209 0.545 0.1449 29.144 0.524 0.1592 26.083 0.595 0.1706 30.435 THYMUS (Gms) %FBW %BRAIN 0.232 0.0832 13.004 0.280 0.0787 14.791 0.164 0.0491 8.1836 0.404 0.1077 21.097 0.382 0.0921 19.691 0.244 0.0668 12.311 0.263 0.0699 14.064 0.207 0.0629 10.304 0.239 0.0685 12.225 UTERUS | (Gms) %FBW %BRAIN | 0.612 0.2195 34.305 0.689 0.1935 36.397 1.025 0.3067 51.148 0.505 0.1346 26.371 0.805 0.1940 41.495 0.669 0.1833 33.754 0.736 0.1957 39.358 0.625 0.1899 31.110 0.569 0.1632 29.105 Mean S.D. 0.115 0.0328 5.9525 0.029 0.0085 1.3740 0.567 0.1619 29.515 0.084 0.0264 4.8238 0.268 0.0754 13.963 0.078 0.0173 4.1511 0.693 0.1978 35.894 0.153 0.0472 7.4421 Group : VIII - 250 mg/kg/day Sex :FEMALES | ANIMAL I OVARIES | SPLEEN | THYMUS I UTERUS | I |(Gms ) %FBW %BRAIN |(Gms ) %FBW %BRAIN I,(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 643345 643347 643351 643358 643423 643441 j 643444 643456 643474 643481 Mean S.D. 0.135 0.0431 7.1353 0.114 0.0433 6.1990 0.095 0.0332 5.1268 0.109 0.0309 6.1167 0.078 0.0265 4.0373 0.132 0.0361 6.9804 0.116 0.0371 5.7312 0.135 0.0413 6.3860 0.134 0.0493 7.1315 0.129 0.0431 6.7469 0.118 0.0384 6.1591 0.019 0.0069 0.9846 0.505 0.1613 26.691 0.449 0.1705 24.415 0.394 0.1376 21.263 0.451 0.1281 25.309 0.882 0.2993 45.652 0.611 0.1672 32.311 0.516 0.1650 25.494 0.593 0.1816 28.051 0.503 0.1849 26.770 0.470 0.1569 24.582 0.537 0.1752 28.054 0.138 0.0470 6.8055 0.283 0.0904 14.958 0.143 0.0543 7.7760 0.176 0.0615 9.4981 0.187 0.0531 10.494 0.298 0.1011 15.424 0.227 0.0621 12.004 0.238 0.0761 11.759 0.259 0.0793 12.252 0.260 0.0956 13.837 0.208 0.0694 10.879 0.228 0.0743 11.888 0.049 0.0171 2.3915 0.592 0.1891 31.290 0.710 0.2696 38.608 0.643 0.2246 34.700 0.639 0.1814 35.859 0.719 0.2440 37.215 1.224 0.3350 64.728 0.700 0.2239 34.585 0.615 0.1883 29.092 0.586 0.2154 31.187 0.463 0.1546 24.215 0.689 0.2226 36.148 0.202 0.0516 10.899 FBW - Final Body Weight I DuPont-5386 Company Sanitized. Does not contain TSCA CBI 868 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES 1 ANIMAL i FBW KIDNEYS (Gms ) (Gms) %FBW LIVER (Gms) %FBW THYROID GLAND (Gms) %FBW | 1 643383 643384 643402 643465 643484 312.70 315.00 294.90 345.90 294.60 2.305 0.7371 2.085 0.6619 2.222 0.7535 2.541 0.7346 2.451 0.8320 10.212 3.2657 8.456 2.6844 7.891 2.6758 10 -237 2.9595 8.697 2.9521 0.018 0.0058 0.016 0.0051 0.017 0.0058 0.017 0.0049 0.015 0.0051 Mean S.D. 312.62 20.928 2.321 0.7438 0.181 0.0606 9.099 2.9075 1.069 0.2431 0.017 0.0053 0.001 0.0004 Group : IV - 25 mg/kg/day Sex FEMALES 1 ANIMAL 1 FBW KIDNEYS (Gms ) (Gms) %FBW 643379 643391 643437 643483 368.10 326.80 343.10 299.70 2.367 0.6430 2.262 0.6922 2.505 0.7301 2.614 0.8722 LIVER (Gms) %FBW 10.036 2.7264 9.563 2.9263 9.046 2.6365 8.265 2.7578 Mean S.D. 334.43 28.713 2.437 0.7344 0.154 0.0986 9.228 2.7617 0.758 0.1211 THYROID GLAND (Gms) %FBW 0.014 0.0038 0.017 0.0052 0.018 0.0052 0.024 0.0080 0.018 0.0056 0.004 0.0018 | | FBW - Final Body Weight DuPont-5386 Company Sanitized. Does not contain T S C A CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : VI - 100 mg/kg/day Sex :FEMALES 1 ANIMAL ! 643360 643373 643381 643382 643412 FBW (Gms) 277.70 356.80 328.10 286.10 327.20 KIDNEYS (Gms) %FBW 2.342 0.8434 2.963 0.8304 2.302 0.7016 2.511 0.8777 2.221 0.6788 LIVER (Gms) %FBW 8.488 3.0565 11.626 3.2584 9.562 2.9144 9.100 3.1807 9.309 2.8450 THYROID GLAND (Gms) %FBW 0.019 0.0068 0.019 0.0053 0.016 0.0049 0.025 0.0087 0.017 0.0052 | 1 Mean S.D. 315.18 32.764 2.468 0.7864 0.296 0.0898 9.617 3.0510 1.191 0.1739 0.019 0.0062 0.003 0.0016 Group : VIII - 250 mg/kg/day Sex :FEMALES 1 ANIMAL 1 643329 643356 643388 643450 643487 FBW (Gms) 368.90 341.10 286.10 429.70 312.00 KIDNEYS (Gms) %FBW 3.198 0.8669 2.497 0.7320 2.248 0.7857 3.379 0.7864 2.200 0.7051 LIVER (Gms) %FBW 11.876 3.2193 11.657 3.4175 9.323 3.2587 12.632 2.9397 9.954 3.1904 Mean S.D. 347.56 55.421 2.704 0.7752 0.549 0.0621 11.088 3.2051 1.390 0.1723 THYROID GLAND (Gms) %FBW 0.017 0.0046 0.015 0.0044 0.021 0.0073 0.020 0.0047 0.024 0.0077 0.019 0.0057 0.004 0.0016 | | FBW - Final Body Weight DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS company Sanitized. Does not contain T S C A CBI I1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 643143 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, 643143 Continued on the next page .... company Sa,,raM d. Doan contain TSCA C B , 872 I) 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643143 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643145 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 643145 Continued on the next page .... Company Sanitized. Does not contain T S C A C B l 873 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643145 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, mild. EPITHELIUM, 643150 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643150 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 874 i1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643150 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643162 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643162 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 875 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group :: I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643162 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : ODONTODYSPLASIA, moderate. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643172 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643172 Continued on the next page Company Sanitized. Does not contain T S C A CBI 876 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643172 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643185 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643185 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI II II-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643185 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBf 878 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643189 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. 643189 Continued on the next page Company Sanitized. Does not contain T S C A CB! I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643189 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643195 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643195 Continued on the next page Com pany Sanitized. Does not contain T S C A CBI 880 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643195 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643204 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643204 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 881 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643204 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE ) DuPont-5386 Company Saniti*!. Doas noi contain tsca CBI 882 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643205 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. EYE(S) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. 643205 Continued on the next page .... Company Sanitized. Does not contain T S C A CB! ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643205 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643210 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643210 Continued on the next page .... Company Sanitized. Does not contain T S C A C B i 884 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gnration Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643210 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 643226 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : TESTES : DEFORMITY, RIGHT. EPIDIDYMIDES : SMALL, RIGHT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643226 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643226 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, mild. UNILATERAL, No Microscopic Abnormality Observed : EPIDIDYMIDES, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643232 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE DuPont-5386 Company Sanitized. Does not contain T S C A CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643235 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. DuPont-5386 643235 Continued on the next page .... Company Sanitized. Does not contain T S C A CB1 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643235 Continued from previous page Histopathology : 643237 No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643237 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 889 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643237 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643241 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643241 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 890 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopie Findings 643241 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S } WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TS C A CBI 891 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643246 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE ) DuPont-5386 CompanySanitized. Does nof contain TSCACBI 892 i) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643253 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, LEFT. EPIDIDYMIDES : SMALL, LEFT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643253 Continued on the next page .... Company Sanitized. Does not contain TSCA C B l 893 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643253 Continued from previous page Histopathology TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, severe. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL, severe. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643262 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643262 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 894 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643262 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643265 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643265 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643265 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : KIDNEYS, NOSE 643268 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE DuPont-5386 643268 Continued on the next page .... 896 smifoM. Ooss nol con|a|nts c a cb[ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643268 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, mild. EPITHELIUM, 643288 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643288 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 897 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643288 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI 898 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic B'indings 643300 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643300 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 899 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643300 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643303 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643303 Continued on the next page .... Company Sanitized. Does not contain T S C A CBl 900 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643303 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643304 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : SPLEEN : DEFORMITY. MANDIBULAR LYMPH NODE : DISCOLORATION, RED. THYMUS : SMALL. DuPont-5386 643304 Continued on the next page Company Sanitized. Does not contain T S C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643304 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYMUS, NOSE, MANDIBLE I DuPont-5386 3jmpany Sanitized. Does no! contain T S C A CB1 902 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643173 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 jmpany Sanitized. Does not eorhan T S C A CE5 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643179 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE ) DuPont-5386 Company Sanitized. Does not contain TSCA CB1 904 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643180 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643202 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, SOFT, RIGHT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM, minimal. SCHWANNOMA [B]. [B]=BENIGN, [M]^MALIGNANT Company Sanitized. Does not contain TSCA CBF )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643228 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE, MANDIBLE 1 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 907 ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643240 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 908 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 543264 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI 909  ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS D o s e Group : I I I - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643272 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : LIVER, KIDNEYS, NOSE, MANDIBLE ) DuPont-5386 Company Sanitized. Does not contain T S C A CB i 910 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643290 Terminal Sacrifice Killed on Day : 91 Exposure Group 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C CBF 911 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643292 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A C 8 I 912 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643293 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, minimal. EPITHELIUM, DuPont-5386 Company Sanitized. Does not contain T S C A CBI 913 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group :: III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643305 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. DuPont-5386 Company Sanitized. Does not contain T S C A CBI 914 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643306 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE ) DuPont-5386 Company Sanitized. Does not contain T S C A C B i 915 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643308 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI 916  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643310 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, mild. ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI 917 i) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref 643159 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION, AMELOBLASTS, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, minimal. FRACTURE/CALLUS, TOOTH. EPITHELIUM, I DuPont-5386 1Company Sanitized. Does not contain T S C A CB 918 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643169 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE DuPont-5386 Company Sanitized. Does not contain TS CA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643175 Accidentally Killed Duration of dosing-days: 77 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, TAN, LEFT. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, GRANULOMATOUS, severe. HEART : INFLAMMATION, SUBACUTE/CHRONIC, moderate. THYMUS : NOT PRESENT. 643175 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643175 Continued from previous page Histopathology : PARATHYROID GLANDS : NOT PRESENT. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, moderate. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. TESTES : SPERMATID RETENTION, SEMINIFEROUS TUBULES, minimal. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, moderate. NOSE : DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM, minimal. INFLAMMATION, SUBACUTE/CHRONIC, mild. NON-PROTOCOL TISSUE : Moderate, ABSCESS, SUBCUTIS. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, PITUITARY GLAND, THYROID GLAND, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM ! DuPont-5386 Company Sanitized. Does not contain T S C A CBI 921 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref 643181 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM, mild. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. ! DuPont-5386 lompany Sanitized. Does not contain T S C A CBI 922 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643206 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE DuPont-5386 Company Sanitized. Does not contain T S C A CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643224 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643243 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HE-PATOCYTE, CENTRI LOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 empany Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643247 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal, HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI I> H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643250 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 1 DuPont-5386 Company Sanitized. Does not contain T S C A CBt 927 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643257 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE Company Sanitized. Does not contain T S C A CBI 928 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643275 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. Company Sanitized. Does no! contain TS CA CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643286 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI 930 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643311 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. 643311 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 931 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group :; V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643311 Continued from previous page Histopathology No Microscopic Abnormality Observed : MANDIBLE 643314 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 643314 Continued on the next page Company Sanitized. Does nof contain T S C A CBI )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643314 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643318 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. 643318 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 933 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643318 Continued from previous page Histopathology : LIVER : FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE I DuPont-5386 Company Sanitized. Does not contain TSCA CBI 934 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643149 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : CALCULUS\CALCULI, minimal. HYPERPLASIA, TRANSITIONAL CELL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, minimal. EPITHELIUM, Company Sanitized. Does not contain TSCA CBl 935 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643151 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FOCUS OF CELLULAR ALTERATION, BASOPHILIC, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE Company Sanitized. Does not contain T S C A CB1 !) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643152 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. ) DuPont-5386 Company Sanitized. Does not contain TSCACBI 937 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643165 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643174 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : HYDRONEPHROSIS, BILATERAL, minimal. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. 643174 Continued on the next page .... Company Sanitized. Does not contain TSCACBl 939 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref 643174 Microscopic & Macroscopic Findings Continued from previous page Histopathology MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643178 No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643178 Continued on the next page .... Company Sanitized. D oes not contain TSCA CBI 940 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643178 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. 643193 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 643193 Continued on the next page .... Company Sanitized. Does not contain T S C A CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 2S0 mg/kg/day Sex-. Males Animal Ref Microscopic & Macroscopic Findings 643193 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. LUNGS : INFLAMMATION, GRANULOMATOUS, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. EYE(S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643193 Continued on the next page .... 942 Company Sanitized. D oes not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref 643193 Microscopic & Macroscopic Findings Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643194 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643194 Continued on the next page Com pany Sanitized. D oes not contain TSCA CBI 943 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643194 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW ) DuPont-5386 Company Sanitized. Does not contain T S C A CBI 944 ) >) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643201 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, moderate. KIDNEYS : HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643201 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 945 I 11-245)6: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ! DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643201 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643215 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643215 Continued on the next page .... company Sanitized. Does not contain T S C A CBI 946 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643215 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW I DuPont-5386 Company Sanitized. Does not contain T S C A CB 947 )1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643220 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : SEMINAL VESICLES : SMALL, LEFT. TESTES : SOFT, BILATERAL. EPIDIDYMIDES : DEFORMITY, LEFT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 643220 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 948 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643220 Continued from previous page Histopathology TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, moderate. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, SEMINAL VESICLES, MANDIBLE 643225 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643225 Continued on the next page .... jmpany Sanitized. Does not contain T S C A CBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I _______________ DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643225 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643234 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643234 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 950 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaiuations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group :; VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643234 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE 643236 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : THYMUS : SMALL. DuPont-5386 643236 Continued on the next page Company Sanitized. Does not contain T S C A H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643236 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : THYMUS, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643252 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643252 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 953 1I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 1 DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643252 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643258 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643258 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 954 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643258 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643259 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643259 Continued on the next page --- Company Sanitized. Does not contain T S C A CBI 955 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings Animal Ref Microscopic & Macroscopic Findings 643259 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. HYPERTROPHY, TUBULAR, minimal. HEART ; CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643259 Continued on the next page .... Company Sanitized. Does not contain TSCA CB! )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS i DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643259 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643260 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643260 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 957 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643260 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. NECROSIS, FOCAL, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW I DuPont-5386 Company Sanitized. Does not contain T S C A CBI 958 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643266 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain T S C A CBI 1I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643283 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. DuPont-5386 Company Sanitized. Does not contain T S C A CBI 960 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643295 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM, mild. DEGENERATION, AMELOBLASTS, minimal. DuPont-5386 Company Sanitized. Does not contain T S C A CBf 961 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643296 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643298 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643298 Continued on the next page .... Company Sanitized. Does not contain T S C A CB! 963 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643298 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643309 Accidentally Killed Duration of dosing-days: 70 Exposure Group : REPRODUCTION Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, MOTTLED, TAN. SMALL INTESTINE : DISTENDED WITH GAS, moderate. SALIVARY GLANDS : EDEMA. SKIN : STAIN, RED, FACE. PLEURAL CAVITY : FLUID, CLEAR, severe. 643309 Continued on the next page .... Company Sanitized. Does not contain T S C A CBI 964 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643309 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYMUS : ATROPHY, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. 643309 Continued on the next page .... Com p&ny Sanitized. Does not contain TSCA CBS I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643309 Continued from previous page Histopathology : ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, mild. EDEMA, mild. PHARYNX/LARYNX : HEMORRHAGE, mild. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, mild. MANDIBLE : NOT PRESENT. No Microscopic Abnormality Observed HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI 966 M-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643315 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, mild. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, moderate. 643315 Continued on the next page .... Company Sanitized. Does not contain TSCA CBl 967 ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643315 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643316 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643316 Continued on the next page .... Company Sanitized, Does not contain TSCA CBI 968 )) ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643316 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE Company Sanitized. Does notcontain TSCACBI 969