Document ev6JNQwdKgYaqBm10NZGyD1Eq

Ipww.w.u--- ----------------------------------------- '-- -- -- -- -- -- -- -- ;---------------------------------- U 2 2 6, WZ/ 469 DuPont-11418 MAA- $27 TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 2 of 5 Laboratory Project ID: DuPont-11418 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) Author: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed on: August 1,2003 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number: Service Code Number: Page 304 of 1602 Company Sanitized. Does not contain TSCA CBI )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________________________________________ ) DuPont-11418 TABLE 48 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION "INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DIGESTIVE SYSTEM LIVER (10) (10) NO ABNORMALITY DETECTED NECROSIS, FOCAL. minimal total observations per lesion INFLAMMATION, SUBACUTE /CHRONIC. minimal mild total observations per lesion HYPERTROPHY, HEPATOCELLULAR, -CENTRILOBULAR. minimal total observations per lesion FATTY CHANGE, PERIPORTAL. minimal mild total observations per lesion FATTY CHANGE, MEDIAN CLEFT. minimal mild total observations per lesion DEGENERATION, HEPATOCELLULAR, FOCAL. mild total observations per lesion 1 1 10 8 1 10 9 61 1 71 22 1 23 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 10 3 3 4 1 5 (10) 1 1 9 1 10 9 9 1 1 1 1 1 1 Company Sanitized. Does not contain TSCA CBI - 305- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED INFLAMMATION, FOCAL. mild total observations per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -306- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Ohe-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 100 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -307- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -308- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg X III V VII DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -309- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION . DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -310 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED , (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -311 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -312- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1Q00 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -313- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -314- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRON1C TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg /kg mg/kg I III V VII DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -315- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS ' DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED CHRONIC PROGRESSIVE NEPHROPATHY. minimal total observations per lesion HYDRONEPHROSIS, UNILATERAL. mild total observations per lesion CYST, TUBULAR. mild total observations per lesion AGGREGATES, LYMPHOID. minimal total observations per lesion (10) 2 7 7 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 1 5 5 1 1 1 1 4 4 Company Sanitized. Does not contain TSCA CBI -316- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) . Males 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg I III V VII DuPont-11418 URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. minimal total observations per lesion ,, (10) 8 2 2 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 7 3 3 Company Sanitized. Does not contain TSCA CBI -317- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS < TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM LUNGS (10) NO ABNORMALITY DETECTED MACROPHAGES, ALVEOLAR, FOCAL. minimal total observations per lesion INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR. minimal total observations per lesion HEMORRHAGE, ALVEOLAR. minimal mild | total observations per lesion I 4 2 2 1 1 2 1 3 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 4 1 1 3 3 3 3 Company Sanitized. Does not contain TSCA CBI -318- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED INFLAMMATION, FOCAL, minimal total observations per lesion (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 Company Sanitized. Does not contain TSCA CBI -319- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -320- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICrTY EVALUATION LESIONS TREATMENT 111 LESION INCIDENCE (NUMERIC) 1 Males 0 10 100 1000 mq/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, TURBINATES. minimal mild total observations per lesion INFLAMMATION, VOMERONASAL ORGAN. minimal total observations per lesion INFLAMMATION, ORAL MUCOSA. minimal total observations per lesion INFLAMMATION, NASOLACRIMAL DUCT. mild total observations per lesion (10) 7 1 1 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 6 1 1 2 1 1 1 1 1 1 Company Sanitized. Does not contain TSCA CBI -321- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC- minimal total observations per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 Company Sanitized. Does not contain TSCA CBI -322- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED t (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -323- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM ! SPLEEN NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -324- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED HEMORRHAGE. minimal mild total observations per lesion (10) 4 5 1 6 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 2 7 1 8 Company Sanitized. Does not contain TSCA CBI -325- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED NECROSIS, LYMPHOID. minimal total observations per lesion LEUKOCYTOSIS, PLASMA CELL, MEDULLARY. mild total observations per lesion ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS. minimal mild total observations per lesion (10) 8 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 6 1 1 1 1 3 3 Company Sanitized. Does not contain TSCA CBI -326- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -327- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI - 328 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED CYST. mild total observatipns per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -329- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. minimal mild total observations per lesion (10) 9 1 1 (10) 9 1 1 (10) 9 1 1 (10) 4 6 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 330- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -331 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXKTTY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED ADRENAL MEDULLA MISSING. (10) 9 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -332- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI - 333 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI - 334- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -335 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg /kg I III V VII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -336- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -337- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -338- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/Kg I III V VII REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -339- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM EPIDIDYMIDES NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID- minimal total observations per lesion (10) 6 4 4 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 5 5 5 Company Sanitized. Does not contain TSCA C8I -340- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION ! LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. minimal mild total observations per lesion (10) 3 7 7 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 4 4 2 6 Company Sanitized. Does not contain TSCA CBI -341 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg I III V VII REPRODUCTIVE SYSTEM SEMINAL VESICLES NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA C8I -342- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number oE animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA C8I -343- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 48 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII SPECIAL SENSES SYSTEM E Y E (S) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT, UNILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL. minimal mild total observations per lesion ATROPHY, RETINAL, UNILATERAL. mild total observations per lesion (10) 5 4 4 4 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 8 1 1 1 2 Company Sanitized. Does not contain TSCA CBI -344- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mq/kq mg/kg mg/kg I III V VII DIGESTIVE SYSTEM LIVER NECROSIS, FOCAL. minimal total observations per lesion INFLAMMATION, SUBACUTE /CHRONIC. minimal total observations per lesion FATTY CHANGE, PERIPORTAL. minimal mild total observations per lesion FATTY CHANGE, MEDIAN CLEFT. minimal mild total observations per lesion (10) 10 10 4 1 5 2 I 3 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 2 2 10 10 2 2 3 2 5 Company Sanitized. Does not contain TSCA CBI -345- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM PANCREAS FOCUS OF CELLULAR ALTERATION, BASOPHILIC, minimal total observations per lesion (1) 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -346- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS > TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -347- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS DESIGNANTOEND-NFEOORPRLEACSOTVICELREYSEIOVNASLUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -348- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS > TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -349- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 vmg/kg mg/kg mg/kg mg/kg I III VII DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 350- H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -351- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mq/kg mg/kg I III V VII DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -352- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -353 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________________ DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED ' (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 354- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _________________________________ __________ TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESTONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 355- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/ kg mg/kg I III V VII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -356- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -357- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS | TREATMENT j LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM LUNGS MACROPHAGES, ALVEOLAR, FOCAL. minimal total observations per lesion HEMORRHAGE, ALVEOLAR.* minimal total observations per lesion (1) 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 358 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -359- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS RESPIRATORY SYSTEM [ TREATMENT 1 1 1 LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII PHARYNX/LARYNX NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -360- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION ! LESIONS TREATMENT LESION INCIDENCE (NUMERIC) I Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED di 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -361 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/ kg mg/kg mg/kg mg/kg I III V VII CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -362- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 363 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________________ DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 364- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________________ DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS HEMORRHAGE. mild total observations per lesion (1) 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 Company Sanitized. Does not contain TSCA CBI -365 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -366- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -367- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 368- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Pile-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM PITUITARY GLAND (1) NO ABNORMALITY DETECTED 1 4 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -369- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mcr/kq I III V VII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. minimal mild total observations per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 4 3 3 6 Company Sanitized. Does not contain TSCA CBI -370- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -371- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -372- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -374- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg /kg mg/kg mg/kg I III V VII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -375 - ) H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS MUSCULAR AND SKELETAL SYSTEM | TREATMENT 1 1 ! LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -376- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg /kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -377- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -378- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I XII V VII REPRODUCTIVE SYSTEM EPIDIDYMIDES NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 1 -379- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -380- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM SEMINAL VESICLES NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -381- ) )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI - 382- > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 TABLE 49 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII SPECIAL SENSES SYSTEM EYE(S) WITH OPTIC NERVE OPTIC NERVE NOT PRESENT, UNILATERAL. (1) 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -383 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________ _______ ______________ ________ _____________DuPont-11418 TABLE 50 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION )1 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 l 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. mild total observations per lesion INFLAMMATION, SUBACUTE/ CHRONIC. minimal mild total observations per lesion FATTY CHANGE, PERIPORTAL. minimal total observations per lesion FATTY CHANGE, MEDIAN CLEFT. minimal mild total observations per lesion (10) 1 8 8 6 6 1 2 3 (10) 2 7 1 8 1 1 (10) 1 1 9 1 10 1 1 (10) 3 7 7 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -384- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg /kg mg/kg II IV VI VIII DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID, minimal total observations per lesion (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 8 2 2 Company Sanitized. Does not contain TSCA CBI - 385- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -386- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _____________________DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI - 387- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 9 Company Sanitized. Does not contain TSCA CBI -388- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CB1 -389 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________ _____________________ ' DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -390- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS > TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg /kg mg/kg II IV VI VIII DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -391 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -392- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICrTY EVALUATION LESIONS DIGESTIVE SYSTEM '' | TREATMENT 1 1 1 LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg /kg mg /kg mg/kg II IV VI VIII RECTUM NO ABNORMALITY DETECTED (10) 10 (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -393 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -394- )) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICrTY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII URINARY SYSTEM KIDNEYS (10) NO ABNORMALITY DETECTED 1 CHRONIC PROGRESSIVE NEPHROPATHY. 1 minimal 1 total observations per lesion 1 AGGREGATES, LYMPHOID. 1 minimal 1 mild 1 total observations per lesion 1 6 3 3 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 6 1 1 2 1 3 Company Sanitized. Does not contain TSCA CBI - 395- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS 1 LESION INCIDENCE (NUMERIC) 11 Females TREATMENT 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBi -396- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT 1 LESION INCIDENCE (NUMERIC) 1 t Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II XV VI VIII RESPIRATORY SYSTEM LUNGS (10) NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR. minimal total observations per lesion HEMORRHAGE, ALVEOLAR.' minimal total observations per lesion i 2 2 2 7 7 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 6 1 1 3 3 Company Sanitized. Does not contain TSCA CBI -397 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII RESPIRATORY SYSTEM TRACHEA (10) NO ABNORMALITY DETECTED INFLAMMATION. minimal total observations per lesion AGGREGATES, LYMPHOID. mild total observations per lesion i 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 Company Sanitized. Does not contain TSCA CBI -398- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES.AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED DEGENERATION, MY0FIBER. mild total observations per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -399- H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. minimal total observations per lesion (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 Company Sanitized. Does not contain TSCA CBI -401 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg /kg mg/kg mg/kg II IV VI VIII CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -402- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -403- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES- AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS DESIGNATED FNOORNS-UNBECOHPLRAOSNTIICCTLOEXSIICOINTSY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED HEMORRHAGE. minimal mild total observations per lesion CYST, EPITHELIAL. mild total observations per lesion (10) 5 4 1 5 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 2 8 8 1 1 Company Sanitized. Does not contain TSCA CBI -404- )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mq/kg mg/kg mq/kg mg/kg II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED LEUKOCYTOSIS, PLASMA CELL, MEDULLARY. minimal total observations per lesion HYPERPLASIA, LYMPHOID. mild total observations per lesion ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS. minimal total observations per lesion (10) 8 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 1 1 Company Sanitized. Does not contain TSCA CBI - 405- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA C8I -406- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -407- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED CYST. minimal mild total observations per lesion (10) 8 1 1 2 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -408- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES. AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL, minimal total observations per lesion (10) 10 (10) 10 (10) 10 (10) 8 2 2 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -409- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED (8) 8 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 9 Company Sanitized. Does not contain TSCA CBI -410- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -411 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg /kg mg/kq mg/kg II IV VI VIII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID, CHOROID PLEXUS. mild total observati'ons per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -412- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (9) 9 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -413- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS | TREATMENT j LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -414- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE NUMERIC) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg II IV VI VIII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -415- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 1 Company Sanitized. Does not contain TSCA CBI -416- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -417- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -418- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS . DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -419- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations 'X ) DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM VAGINA ESTRUS STAGE: METESTRUS. ESTRUS STAGE: ESTRUS.' ESTRUS STAGE: PROESTRUS. (10) 4 2 4 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 2 3 5 Company Sanitized. Does not contain TSCA CBI - 420- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION 1 LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of. a number indicates the lesion specified was not identified (10) 10 Company Sanitized. Does not contain TSCA CBI -421 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII CUTANEOUS SYSTEM SKIN ; NO ABNORMALITY DETECTED DERMATITIS, FOCAL. minimal total observations per lesion (10) 9 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 9 1 1 Company Sanitized. Does not contain TSCA CBI - 422 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 50 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR SUBCHRONIC TOXICITY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII SPECIAL SENSES SYSTEM EYE(S ) WITH OPTIC NERVE (10) NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT, UNILATERAL. OPTIC NERVE NOT PRESENT, BILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL. minimal total observations per lesion FOLD/ROSETTE, RETINAL. minimal total observations per lesion , 8 5 2 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 5 4 1 4 4 1 1 1 Company Sanitized. Does not contain TSCA CBI -423- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 51 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. minimal total observations per lesion ECTOPIC THYMUS TISSUE. (10) 10 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 7 2 2 1 Company Sanitized. Does not contain TSCA CBI -424- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 51 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) 1 Company Sanitized. Does not contain TSCA C8I -425 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 51 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS NON-NEOPLASTIC LESIONS DESIGNATED FOR RECOVERY EVALUATION LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM VAGINA ESTRUS STAGE: PROESTRUS. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified !D 1 Company Sanitized. Does not contain TSCA CBI - 426 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 52 SUMMARY OF CLINICAL OBSERVATIONS IN Pi MALE RATS GROUP : DOSE (MG/KG/DAY): NUMBER IN GROUP: OBSERVATIONS 1-0 0 20 NUMBER OF RATS WITH GIVEN SIGN III-O V-0 VII10 100 1000 20 20 20 ALOPECIA COLORED DISCHARGE RIGHT EYE(S) SORE 3 1 0 2 0 0 12 00 10 There were no statistically significant trends try Cochran-Armitage trend test; p < 0.05. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -427- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 53 SUMMARY OF CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION DuPont-11418 GROUP : DOSE (MG/KG/DAY): NUMBER IN GROUP: NUMBER IN GESTATION3: OBSERVATIONS53 II-O 0 20 19 NUMBER OF RATS WITH GIVEN SIGN IV- 0 10 20 18 VI-0 100 20 20 VIII-0 1000 20 17 ALOPECIA 3835 COLORED DISCHARGE RIGHT EYE(S ) 1 0 0 0 a The number of animals in gestation includes only the animals that exhibit b Clinical observations of "cageboard plugs," "sperm positive," "sperm negative," and "vaginal plug" are reported in the Appendix, "Individual Clinical Observations And Mortality Data In Px Female Rats During Gestation," and were used to calculate Reproductive Indices. There were no statistically significant trends by Cochran-Armitage trend test; p < 0.05. Company Sanitized. Does not contain TSCA CBi -428- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 54 SUMMARY OF CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION OBSERVATIONS GROUP : DOSE (MG/KG/DAY): NUMBER IN GROUP: NUMBER IN LACTATION: NUMBER OF RATS WITH GIVEN SIGN II-O 0 20 19 IV-0 10 20 20 VI-0 100 20 19 VIII-0 1000 20 19 ALOPECIA SORE TOTAL N O . OF RATS WITH MASSES SITE: MASS 0.5 cm SHOULDER 3926 0001 0001 0001 There were no statistically significant trends by Cochran--Armitage trend test; p < 0.05. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -429- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 55 MEAN BODY WEIGHTS (grams) OF Pi MAT E RATS DuPont-11418 Group : Dosage(mg/kg/day): 1-0 0 Test Day 70 537.3 49.1(20 ) Day 77 540.0 53.1(20 ) Day 84 551.7 53.6(20 ) Day 91 560.5 57.0(20 ) Day 98 568.6 56.6(20 ) Day 105 577.0 58.6(20 ) Data summarized as : Mean Standard Deviation (n) III-O 10 522.8 35.7(20 ) 513.1 35.0(20 ) 533.6 37.5(20 ) 543.3 41.1(20 ) 555.3 40.2(20 ) 563.2 41.8(20 ) V-0 100 507.4 44.3(20 ) 501.0 40.0(20 ) 517.8 40.4(20 ) 527.3 41.6(20 ) 541.4 44.2(20 ) 549.5 42.2(20 ) VII-0 1000 524.3 47.6(20 ) 524.2 46.9(20 ) 534.8 49.2(20 ) 541.2 50.0(19 ) 551.1 52.9(19 ) 554.7 51.8(19 ) m e r e were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Note: Day 70 = last weigh day of premating period, Day 77 = first weigh day of cohabitation period. Company Sanitized. Does not contain TSCA CBI -430- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 56 MEAN BODY WEIGHT GAINS (grams) OF Pi MALE RATS DuPont-11418 Group: Dosage(mg/kg/day): i-O 0 Test Day 70-77 2.8 9.9(20 ) Day 77-84 11.6 6 .8(20 ) Day 84-91 8.9 6.5(20 ) Day 91-98 8.0 8 .1(20 ) Day 98-105' 8.5 6.4(20 ) Day 70-105 ____________________ Data summarized as: Mean 39.8 18.1(20 ) Standard Deviation (n) III-O 10 -9.7 10.6(20 ) 20.5 10.1(20 ) 9.7 6.8(20 ) 12.0 5.4(20 ) 7.9 4.8(20 ) 40.4 12.3(20 ) V-0 100 -6.3 21.1(20 ) 16.8 10.8(20 ) 9.5 9.2(20 ) 14.2 5.6(20 ) 8.1 5.8(20 ) 42.1 15.8(20 ) VII-0 1000 - 0.1 7.7(20 ) 10.6 6.1(20 ) 8.7 4.7(19 ) 9.9 8.2(19 ) 3.5 8.3(19 ) 33.2 12.8(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Note: Day 70 = last weigh day of premating period, Day 77 = first weigh day of cohabitation period Company Sanitized. Does not contain TSCA O n H-25425: Subchronic Toxicity s'o-xnvy oavagc avuy in Rats wiiii Qne-Qcneration Reproduction Evaluations TABLE 57 MEAN BODY WEIGHTS (grams) OF Pi FEMALE RATS DURING GESTATION DuPont-11418 Group : Dosage(mg/kg/day): II-O 0 IV-0 10 VI-0 100 VIII-0 1000 Gestation Day 0 Day 7 > 297.2 24.0(18 )a 326.4 27.0(18 ) 298.3 35.4(18 ) 328.6 33.0(18 ) 299.8 28.7(19 ) 331.2 32.2(19 ) 301.2 30.0(16 ) 330.2 31.2(16 ) Day 14 361.5 26.7(18 ) Day 21 Data summarized as: 447.5 33.2(18 ) Mean Standard Deviation (n) 368.1 33.8(18 ) 444.3 35.9(18 ) 366.8 36.0(19 ) 438.6 37.9(19 ) 365.3 36.4(16 ) 448.3 46.9(16 ) a The number of animals in gestation includes only the animals that exhibit evidence of copulation. There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI -432- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 58 MEAN BODY WEIGHT GAINS (grams) OF Pi FEMALE RATS DURING GESTATION DuPont-11418 Group : Dosage(mg/kg/day): II-O 0 Gestation Day 0-7 29.2 8.4(18 )a Day 7-14 35.1 12.7(18 } Day 14-21 86.0 13.5(18 ) Day 0-21 150.3 16.3(18 ) Data summarized as : Mean Standard Deviation (n) IV-0 10 30.4 11.9(18 ) 39.4 11.2(18 ) 76.2 15.9(18 ) 146.0 24.9(18 ) VI-0 100 31.4 8.6(19 ) 35.5 9.1(19 ) 71.9 22.1(19 ) 138.8 25.4(19 ) VIII-0 1000 28.9 5.3(16 ) 35.1 6.9(16 ) 83.0 17.2(16 ) 147.1 21.4(16 ) a The number of animals in gestation includes only the animals that exhibit evidence of copulation. There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA o 00 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 59 MEAN BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION DuPont-11418 Group: Dosage(mg/kg/day): II-O 0 Lactation Day 0 337.5 27.6(19 ) Day 7 350.9 27.4(19 ) Day 14 ' 362.8 25.0(19 ) Day 21 Data summarized as: 336.5 ____________18.3(19 ) Mean Standard Deviation (n) IV-0 10 346.9 32.5(20 ) 358.4 30.6(20 ) 368.9 26.5(19 ) 347.1 24.6(19 ) VI-0 100 336.1 30.8(18 )a 356.9 31.4(19 ) 366.0 28.5(19 ) 348.2 22.6(19 ) VIII-0 1000 332.9 37.2(19 ) 354.5 33.7(19 ) 367.5 31.0(19 ) 347.1 29.2(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test, a N = 18; data inadvertently not recorded for Animal No. 665247 on lacatation day 0. Company Sanitized. Does not contain TSCA CBI -434- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 60 MEAN BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING LACTATION Group : Dosage(mg/kg/day): Lactation Day 0-7 Day 7-14 Day 14-21 Day 0-21 II-O 0 13.4 11.6(19 ) 11.9 9.0(19 ) -26.3 18.1(19 ) -1 . 1 23.3(19 ) IV-0 10 11.5 18.2(20 ) 9.9 11.8(19 ) -2 1 . 8 13.0(19 ) 2.6 17.2(19 ) VI-0 100 18.3 14.0(18 )a 9.1 10.8(19 ) -17.8 13.1(19 ) 11.0 18.7(18 )a VIII-0 1000 2 1 .6 # 15.2(19 ) 13.1 15.0(19 ) -20.4 15.1(19 ) 14.3# 21.4(19 ) Standard Deviation (n) # Statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test, a N = 18; data inadvertently not recorded for Animal No. 665247 on lacatation day 0. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -435- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 61 MEAN DAILY FOOD CONSUMPTION (grams) OF Pi FEMALE RATS DURING GESTATION DuPont-11418 Group : Dosage(mg/kg/day): II-O 0 Gestation Day 0-7 22.8 2.0(18 )a Day 7-14 26.0 2.5(18 ) Day 14-21 26.3 2.7(18 ) Day 0-21 25.1 2.1(18 ) Data summarized as: Mean Standard Deviation (n) IV-0 10 23.7 3.0(18 ) 27.1 3.0(18 ) 26.4 2.4(18 ) 25.7 2.3(18 ) VI-0 100 23.8 3.0(19 ) 26.6 3.6(19 ) 26.1 2.9(19 ) 25.5 2.9(19 ) VIII-0 1000 23.6 2.3(16 25.9 2.7(16 26.7 2.1(16 25.4 2.2(16 a The number of animals in gestation includes only the animals that exhibit evidence of copulation. There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI -436- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 62 MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) OF Pi FEMALE RATS DURING GESTATION Group : Dosage(mg/kg/day): II-O 0 IV-0 , 10 Gestation Day 0-7 0.182 0.047(18 )a 0.182 0.064(18 ) Day 7-14 0.190 0.055(18 ) 0.207 0.053(18 ) Day 14-21 0.470 0.076(18 ) 0.415 0.094(18 ) Day 0-21 Data summarized as: Mean 0.286 0.027(18 ) Standard Deviation (n) 0.271 0.044(18 ) VI-0 100 0.186 0.037(19 ) 0.190 0.037(19 ) 0.398 0.134(19 ) 0.261 0.048(19 ) VIII-0 1000 0.175 0.029(16 ) 0.192 0.024(16 ) 0.442 0.077(16 ) 0.275 0.025(16 ) a The number of animals in gestation includes only the animals that exhibit evidence of copulation. There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA o DO H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 63 SUMMARY OF REPRODUCTIVE INDICES: Pi GENERATION MATERNAL GROUP: DOSE (mg/kg/day): MATING INDEX (%) (No. copulated/cohoused) FERTILITY INDEX (%) (No. pregnant/copulated) GESTATION LENGTH (days) (No. in group) II-O 0 IV-0 10 100 (2 0 /2 0 ) 95 (19/20) 22.2 (18) 100 (2 0 /2 0 ) 100 (2 0 /2 0 ) 22.7 (18) VI-0 100 100 (2 0 /2 0 ) 95 (19/20) 22.6 (19) VIII-0 1000 100 (2 0 /2 0 ) 95 (19/20) 22.3 (16) NUMBER OF IMPLANTATION SITES per pregnant female 14.7 Standard Deviation (No. in group) 2.1(19) 14.5 3.3(2 0 ) 14.0 3.9(19) 15.4 2.4(19) IMPLANTATION EFFICIENCY (%)a 90.5 80.8 89.5 Standard Deviation(No. in group) 9.3(19) 19.1(20) 10.3(19) a Number of pups born/number of implantation sites X 100. 92.6 11.8(19) There were no statistically significant trends in mating or fertility indices by Cochran-Armitage test; p < 0.05. There were no statistically significant trends in gestation length or number of implantation sites by Jonckheere-Terpstra test; p < 0.05. Company Sanitized. Does not contain TSCA CBI -438- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 64 SUMMARY OF SPERM PARAMETERS IN Pi MALE RATS Group Dose (mg/kg/day) MOTILITY Percent Motile Standard Deviation MORPHOLOGY Percent Normal Standard Deviation 1-0 0 86 1 1 (1 0 ) 99.4 0.7(10) III-O 10 89 9(10) 99.2 1.3(10) V-0 100 91 8 (1 0 ) 99.1 0 .8 (1 0 ) VII-0 1000 90 5(10) 99.0 0.9(10) EPIDIDYMAL SPERM (Millions) Per Cauda 264.6 Standard Deviation 14.9(10) 254.4 6.5(10) Per gram Cauda Standard Deviation 985.8 125.8(10) 961.2 1 0 2 .2 (1 0 ) TESTICULAR SPERMATIDS (Millions) Per Testis 136.3 Standard Deviation 4.4(10) 134.2 4.2(10) Per gram Testis Standard Deviation Data summarized as: 84.5 9.5(10) Mean Standard Deviation 84.0 4.5(10) (n) 258.4 10.5(10) 1101.5 134.2(10) 132.2 5.2(10) 82.4 9.0(10) 252.2 9.0(10) 1065.2 141.8(10) 131.9 7.6(10) 80.2 15.7(10) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI -439- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 65 MEAN ESTROUS CYCLE PARAMETERS AND PRECOITAL INTERVAL IN Pi FEMALE RATS Percent Percent Percent of Days of Days of Days Mean Cycle Dose in in in Length Group (mg/gk/day) N Estrus Diestrus Proestrus (days) Mean Precoital Interval (days) II-O 0 2 0 34% 56% 1 0 % 4.1 (0 .3 )a 3.0(3.4) IV-0 10 2 0 30% 62% 8 % 4.1(0.3) 2 .9(1.7) VI-0 1 0 0 2 0 31% 60% 8 % 4.2(0.4) 3.0(2.5) VIII-O 1000 2 0 26% 62% 12% a Standard deviation is presented in parentheses. 4.3 (0.4) 2 .8 (1 .5) There were no statistically significant trends in estrous cycle length or precoital interval by Jonckheere-Terpstra test (p < 0.05). - 440Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 66 MEAN PUP NUMBERS AND SURVIVAL: Fi GENERATION MATERNAL GROUP II-O IV-0 VI-0 VIII-0 DOSE (mg/kg/day) 0 10 100 1000 N 19 20a 19 19 MEAN NUMBER OF PUPS/LITTER Born 13.4 11.8 12.5 14.3 Born Alive Day 4 Preculling Day 4 Postculling 13.4 13.3 7.9 11.4 11.9 7.7 12.4 12.4 7.6 14.2 14.1 7.9 Day 7 7.8 7.7 7.6 7.9 Day 14 7.8 7.7 7.6 7.9 Day 21 Born Born Alive Day 4 Preculling Day 4 Postculling 7.8 7.7 MEAN NUMBER OF MALE PUPS/LITTER 6.6 6.1 6.6 6.2b 6.5 6.0 3.9 3.8 7.6 6.7 6.7 6.7 4.0 7.9 7.6 7.5 7.4 4.0 Day 7 3.9 3.8 4.0 4.0 Day 14 3.9 3.8 4.0 4.0 Day 21 3.9 3.8 MEAN NUMBER OF FEMALE PUPS/LITTER 4.0 4.0 Born Born Alive Day 4 Preculling Day 4 Postculling 6.8 6.0 5.7 6.7 6.8 6.0b 5.7 6.7 6.8 5.9 5.7 6.7 4.0 3.9 3.6 3.9 Day 7 3.9 3.9 3.6 3.9 Day 14 3.9 3.9 3.6 3.9 Day 21 Sex Ratio (males) 3.9 SURVIVAL <%> 0.49 3.9 0.53 3.6 0.54 3.9 0.53 Gestation Indexc Mean % Born Alive 0-4 Day Viability 100.0 100.0 99.6 95.0 93.8 99.6 100.0 99.4 100.0 100.0 99.0 99.3 Lactation Index^ 99.3 100.0 99.3 100.0 Litter Survival 100.0 100.0 100.0 100.0 a N = 19 for Day 4 Preculling to Day 21, 0-4 Day Viability, Lactation Index, and Litter Survival, b N = 18 due to a missexed pup. c Percent litters delivered having at least one live pup. d Mean percent survival from Day 4 Postculling to Day 21. e Percent litters born with at least one pup alive on Day 21. There were no statistically significant trends in number of pups, sex ratio, mean percent born alive, 0-4 day viability, or lactation index by Jonckheere-Terpstra test; p < 0.05. There were no statistically significant trends in gestation index and litter survival by Cochran-Armitage test; p < 0.05. Statistics were performed on combined pups per litter only. Male and female data are presented for information only. -441 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 67 SUMMARY OF PUP CLINICAL OBSERVATIONS: Fj GENERATION DuPont-11418 MATERNAL GROUP: DOSE (mg/kg/day): TOTAL NUMBER OF LITTERS: II-O 0 19 IV-0 10 19 VI-0 100 19 VIII 1000 19 OBSERVATIONS SMALL WHOLE BODY 0 0 1 { 1) 1( TOTAL NUMBER OF SIGNS NUMBER OF LITTERS AFFECTED 001 1 0011 Numbers outside the parentheses are the number of pups affected; the numbers in parentheses are the number of litters affected. There were no statistically significant trends by Cochran-Armitage test; p < 0.05, Company Sanitized. Does not contain TSCA CBI -442- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 68 MEAN PUP WEIGHTS: Fj GENERATION MATERNAL GROUP: DOSE (mg/kg/day): N: II-O 0 19 IV-0 10 19 VI-0 100 19 VIII-0 1000 19 Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN PUP WEIGHTS (grams) 6.8 (0.7) 7.2 (0.7) 7.2 (0.8) 6.6 (0.6) 11.2 (1.5) 12.2 (1.7) 12.2 (2.0) 10.9 (1.7) 11.2 (1.6) 12.3 (1.8) 12.2 (2.1) 10.9 (1.7) 18.5 (2.4) 19.3 (2.1) 19.5 (2.7) 17.6 (2.4) 37.9 (3.8) 38.4 (3.0) 39.2 (4.0) 37.2 (3.6) 60.4 (6.5) 62.7 (4.4) 63.6 (6.0) 60.7 (5.7) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN MALE PUP WEIGHTS (grams) 7.1 (0.7) 7.4 (0.6) 7.4 (0.8) 6.8 (0.7) 11.7 (1.6) 12.5 (1.7) 12.4 (2.0) 11.2 (1.6) 11.6 (1.7) 12.5 (1.7) 12.5 (2.0) 11.2 (1.7) 19.0 (2.5) 19.8 (2.0) 19.9 (2.5) 18.2 (2.4) 38.6 (4.0) 39.0 (3.1) 39.9 (3.8) 38.0 (3.6) 61.9 (6.9) 64.2 (4.9) 65.2 (5.6) 62.7 (6.2) MEAN FEMALE PUP WEIGHTS (grams) Day 0 6.6 (0.6) 7.0 (0.7) 7.0 (0.9) 6.4 (0.7) Day 4 Preculling 10.9 (1.4) 11.9 (1.8) 11.8 (2.1) 10.5 (1.7) Day 4 Postculling 10.9 (1.5) 12.0 (1.8) 11.9 (2.2) 10.5 (1.8) Day 7 18.0 (2.3) 18.9 (2.2) 18.8 (2.9) 17.1 (2.4) Day 14 37.2 (3.8) 37.7 (2.9) 38.4 (4.2) 36.4 (3.6) Day 21 58.9 (6.5) 61.0 (4.0) 61.8 (6.0) 58.7 (5.3) Data summarized as: Mean (Standard Deviation) There were no statistically significant trends by linear contrast of least square means; p < 0.05. Note: Statistical analyses were conducted on the combined pup weights. Male and female data are presented for information only. - 443Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 69 SUMMARY OF CLINICAL OBSERVATIONS IN F, MALE RATS GROUP : DOSE (mg/kg/day): NUMBER IN GROUP: OBSERVATIONS 1-1 0 19 NUMBER OF RATS WITH GIVEN SIGN III-l 10 19 V-l 100 19 VII- 1000 19 ALOPECIA 21 2 0 COLORED DISCHARGE NOSE 01 00 PREPUTIAL SEPARATION COMPLETE 19 19 19 19 SORE 01 00 There were no statistically significant trends by Cochran-Armitage trend test; p < 0.05. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -444- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 70 SUMMARY OF CLINICAL OBSERVATIONS IN FxFEMALE RATS GROUP : DOSE (%): NUMBER IN GROUP: OBSERVATIONS II-l 0 19 NUMBER OF RATS WITH GIVEN SIGN IV-1 10 19 VI-1 100 19 VIII-1 1000 19 ALOPECIA ENOPHTHALMUS VAGINAL PATENCY COMPLETE 01 00 19 19 00 10 19 19 There were no statistically significant trends by Cochran-Armitage trend test; p < 0.05. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -445- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________ DuPont-11418 TABLE 71 MEAN BODY WEIGHTS (grams) OF Fj MATE RATS Group : Dosage(mg/kg/day) : 1-1 0 Test Day 1 60.6 7.9(19 ) Day 8 104.8 12.4(19 ) Day 15 170.0 18.6(19 ) Day 22 236.9 24.2(19 ) Day 36 Data summarized as: 362.7 Mean 36.0(19 ) Standard Deviation (n) III-l 10 62.3 6.0(19 ) 108.0 10.2(19 ) 174.1 15.3(19 ) 241.6 17.7(19 ) 361.0 32.0(19 ) V-l 100 65.6 6.8(19 ) 114.1 12.0(19 ) 180.9 19.7(19 ) 248.6 26.0(19 ) 372.6 35.8(18 )a VII-1 1000 62.4 5.5(19 ) 107.4 10.2(19 ) 170.3 17.3(19 ) 234.0 21.6(19 ) 356.7 32.9(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test, a N = 18; data inadvertently not recorded for Animal No. 670403 on test day 36. Company Sanitized. Does not contain TSCA CBI -446- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 72 MEAN BODY WEIGHTS GAINS (grams) OF Fi MALE RATS DuPont-11418 Group : Dosage(mg/kg/day): 1-1 0 Test Day 1-8 , 44.3 5.9(19 ) Day 8-15 65.1 7.6(19 ) Day 15-22 67.0 7.8(19 ) Day 22-36 125.8 15.6(19 ) Day 1-36 Data summarized as: 302.2 32.0(19 ) Mean Standard Deviation (n) III-l 10 45.7 5.4(19 ) 66.2 6.1(19 ) 67.5 5.9(19 ) 119.4 22.1(19 ) 298.8 29.6(19 ) V-l 100 48.5 5.9(19 ) 66.8 9.1(19 ) 67.7 8.4(19 ) 122.3 16.0(18 )a 306.7 30.6(18 )a VTT-1 1000 45.0 6.2(19 ) 62.9 10.0(19 ) 63.7 8.0(19 ) 122.7 15.5(19 ) 294.3 30.2(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test, a N = 18; data inadvertently not recorded for Animal No. 670403 on test day 36. Company Sanitized. Does not contain TSCA CBI - 447- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE73 MEAN BODY WEIGHTS (grams) OF F1FEMALE RATS ) DuPont-11418 Group: Dosage(mg/kg/day): II-l 0 Test Day 1 58.9 6.4(19 ) Day 8 97.6 10.0(19 ) Day 15 144.1 14.4(19 ) Day 22 177.7 17.5(19 ) Day 36 ________;_______________ 26.1(19 Data summarized as: Mean 228.3 ) Standard Deviation (n) IV-1 10 60.3 4.6(19 ) 100.3 9.5(19 ) 143.7 14.9(19 ) 178.3 20.9(19 ) 225.0 30.0(19 ) VI-1 100 60.9 6.8(19 ) 100.4 12.4(19 ) 144.4 14.5(19 ) 178.4 17.3(19 ) 229.1 18.4(18 ) VIII-1 1000 59.0 4.9(19 ) 99.5 11.4(19 ) 145.5 16.4(19 ) 177.9 19.9(19 ) 223.6 28.1(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend.test Company Sanitized. Does not contain TSCA CBI -448- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 74 MEAN BODY WEIGHTS GAINS (grams) OF Fi FEMALE RATS DuPont-11418 Group : Dosage(mg/kg/day): II-l 0 Test Day 1-8 38.8 4.6(19 ) Day 8-15 46.5 6.6(19 ) Day 15-22 33.5 7.9(19 ) Day 22-36 50.7 11.5(19 ) Day 1-36 Data summarized as: 169.5 21.7(19 ) Mean " Standard Deviation (n) IV-1 10 40.0 5.7(19 ) 43.4 6.9(19 ) 34.6 9.4(19 ) 46.8 12.7(19 ) 164.7 27.7(19 ) ~~ VI-1 100 VIII-1 1000 39.5 6.8(19 ) 40.5 7.8(19 ) 44.0 4.7(19 ) 46.0 6.3(19 ) 33.9 7.4(19 ) 32.4 7.6(19 ) 48.9 6.1(18 ) 45.8 12.2(19 ) 167.7 164.7 14.4(18 ) 25.8(19 ) ~ ' ----------- There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA o CD )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 75 .MEAN DAILY FOOD CONSUMPTION (grams) OF F, MATE RATS ) DuPont-11418 Group : Dosage(mg/kg/day);: 1-1 0 Test Day 1-8 12.0 1.3(19 ) Day 8-15 19.3 2.2(19 ) Day 15-22 25.1 3.0(19 ) Day 22-36 29.0 3.6(19 ) Day 1-36 Data summarized as: 22.9 2.6(19 ) Mean Standard Deviation (n) III-l 10 12.8 1.5(19 ) 19.9 1.9(19 ) 25.5 2.3(19 ) 29.4 2.6(19 ) 23.4 1.9(19 ) ~ V-l 100 12.9 1.3(19 ) 20.4 2.8(19 ) 25.9 3.6(19 ) 29.7 5.0(19 ) 23.7 2.8(19 ) ~' VII-1 1000 12.3 1.2(19 ) 19.2 2.3(19 ) 24.3 2.6(19 ) 28.3 2.9(19 ) 22.5 2.1(19 ~ ~-- There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI -450- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 76 MEAN DAILY FOOD EFFICIENCY (grams weight gain/grams food consumed) OF Fi MALE RATS Group : Dosage(mg/kg/day) : 1-1 0 Test Day 1-8 0.527 0.033(19 ) Day 8-15 0.483 0.029(19 ) Day 15-22 0.383 0.030(19 ) Day 22-36 0.310 0.018(19 ) Day 1-36 Data summarized as: 0.378 0.016(19 ) Mean Standard Deviation (n) III-l 10 0.511 0.034(19 ) 0.475 0.025(19 ) 0.379 0.026(19 ) 0.289 0.043(19 ) 0.365 0.019(19 ) V-l 100 0.535 0.024(19 ) 0.469 0.020(19 ) 0.375 0.031(19 ) 0.303 0.028(18 )a 0.374 0.019(18 )a VII-1 1000 0.521 0.032(19 ) 0.467 0.040(19 ) 0.374 0.036(19 ) 0.310 0.027(19 ) 0.374 0.016(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test, a N = 18; body weight data inadvertently not recorded for Animal No. 670403 on test day 36. Company Sanitized. Does not contain TSCA C8I - 451- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 77 MEAN DAILY FOOD CONSUMPTION (grams) OF F, FEMALE RATS ) DuPont-11418 Group : Dosage(mg/kg/day): II-l 0 Test Day 1-8 11.3 0.9(19 ) Day 8-15 16.4 1.6(19 ) Day 15-22 18.8 1.7(19 ) Day 22-36 19.2 2.2(19 ) Day 1-36 Data summarized as: Mean 17.0 1.6(19 ) ~~ Standard Deviation (n) IV-1 10 11.8 1.4(19 ) 16.9 2.1(19 ) 18.8 2.9(19 ) 19.0 3.0(19 ) 17.1 2.3(19 ) VI-1 100 VIII-1 1000 11.5 1.6(19 ) 11.9 1.4(19 ) 16.4 2.0(19 ) 17.1 2.2(19 ) 18.6 2.0(19 ) 18.6 1.9(19 ) 19.5 3.4(19 ) 19.1 2.1(19 ) 17.1 17.2 1.5(19 ) 1.8(19 ) ~~ ----------------- There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI 452 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 78 MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) OF Fi FEMALE RATS DuPont-11418 Group : Dosage(mg/kg/day) ;: II-l 0 Test Day 1-8 0.490 0.041(19 ) Day 8-15 0.406 0.042(19 ) Day 15-22 0.255 0.054(19 ) Day 22-36 0.187 0.032(19 ) Day 1-36 Data summarized as: 0.285 0.024(19 ) Mean Standard Deviation (n) IV-1 10 0.483 0.036(19 ) 0.366 0.031(19 ) 0.261 0.042(19 ) 0.174 0.036(19 ) 0.274 0.020(19 ) VI-1 100 0.489 0.039(19 ) 0.386 0.042(19 ) 0.261 0.051(19 ) 0.186 0.023(18 ) 0.283 0.016(18 ) VIII-1 1000 0.482 0.046(19 ) 0.384 0.030(19 ) 0.247 0.047(19 ) 0.169 0.035(19 ) 0.273 0.023(19 ) There were no statistically significant trends at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA O CD H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 79 SUMMARY OF DEVELOPMENTAL LANDMARKS IN Fj RATS OBSERVATIONS AGE (Days)a PREPUTIAL SEPARATION - Fx MALE RATS GROUP : DOSE (mg/kg/day): N: Number of Rats with Given Sign 1-1 III-l V-l VII-1 0 10 100 1000 19 19 19 19 41.5 1.7 41.4 1.3 41.5 1.6 42.1 1.5 VAGINAL PATENCY - Fx FEMALE RATS OBSERVATIONS GROUP : DOSE (mg/kg/day): N: Number of Rats with Given Sign II-l IV-1 VI-1 VIII-1 0 10 100 1000 19 19 19 19 AGE (Days)a Data summarized as: Mean Standard Deviation 31.3 1.6 31.1 1.4 31.6 1.5 31.7 1.5 a Age was calculated as follows using data presented in the Appendix, "Individual Clinical Observations, Developmental Landmarks, and MortalityData for Fx Male and Female Rats:" Test day + 20 days = Age (days). There were no statistically significant trends by Jonckheere-Terpstra test (p < 0.05) . -454- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 80 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MATE. RATS - Fi ADULT MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) Group: Dosage(mg/kg) 1-1 III-l 0 10 Final Body Weight 393.4 39.9(19) 394.1 32.4(19) Liver 18.341 2.949(19) 18.194 1.932(19) Thyroid Gland , 0.021 0.005(19) 0.018 0.004(19) Testes 3.089 0.305(19) 3.190 0.263(19) Epididymides 0.724 0.062(19) 0.741 0.075(19) Prostate 0.449 0.089(19) 0.475 0.060(19) Seminal Vesicles 1.298 0.153(19) 1.348 0.162(19) Brain 1.956 0.079(19) 1.976 0.117(19) V-l 100 397.1 38.9(19) 17.880 2.272(19) 0.021 0.005(19) 3.357 0.406(19) 0.791 0.097(19) 0.476 0.112(19) 1.350 0.187(19) 1.979 0.093(19) VII-1 1000 386.2 36.3(19) 17.782 2.393(19) 0.021 0.006(18) 3.200 0.166(19) 0.733 0.065(19) 0.434 0.074(19) 1.249 0.241(19) 1.916 0.074(19) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -455- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 80 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Ft ADULT MEAN RELATIVE ORGAN WEIGHTS (% of body weight) Group: Dosage(mg/kg) Liver/ Final Body * 100 1-1 0 4.644 0.467(19) III-l 10 4.616 0.292(19) Thyroid Gland/ Final Body * 100 0.005 0.001(19) 0.005 0.001(19) Testes/ Final Body * 100 0.792 0.099(19) 0.814 0.090(19) Epididymides/ Final Body * 100 0.186 0.025(19) 0.188 0.016(19) Prostate/ Final Body * 100 0.114 0.021(19) 0.122 0.020(19) Seminal Vesicles/ Final Body * 100 . 0.333 0.046(19) 0.345 0.057(19) Brain/ Final Body * 100 0.502 0.055(19) 0.503 0.029(19) V-l 100 4.499 0.322(19) 0.005 0.001(19) 0.849 0.097(19) 0.200 0.020(19) 0.120 0.025(19) 0.341 0.040(19) 0.501 0.037(19) VII-1 1000 4.592 0.303(19) 0.005 0.002(18) 0.834 0.068(19) 0.191 0.023 (19) 0.113 0.020(19) 0.324 0.057(19) 0.500 0.047(19) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -456- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 80 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fj ADULT SAN RELATIVE ORGAN WEIGHTS (% organ to brain weight ratio) Group: Dosage(mg/kg) 1-1 III-l V-l VII-1 0 10 100 1000 Liver/ Brain * 100 939.300 161.625(19) 920.489 77.991(19) 903.253 102.214(19) 928.167 121.927(19) Thyroid Gland/ Brain * 100 1.083 0.288(19) 0.939 0.219(19) 1.067 0.225(19) 1.071 0.320(18! Testes/ Brain * 100 158.081 16.060(19) 161.860 14.729(19) 169.804 19.879(19) 167.124# 7.893(19) Epididymides/ Brain * 100 37.065 3.615(19) 37.520 3.111(19) 39.960 4.416(19) 38.276 3.232(19) Prostate/ Brain * 100 23.006 4.748(19) 24.152 3.397(19) 24.001 5.339(19) 22.728 4.118(19) Seminal Vesicles/ Brain * 100 66.378 7.352(19) 68.409 8.556(19) 68.283 9.473(19) 65.203 12.520(19) Data summarized as: Mean Standard Deviation (n) # Statistically significant difference from control at p < 0.05 by Jonckheere-Terpstra trend test. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -457- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 81 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Ft ADULT MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) Group: Dosage(mg/kg) II-l 0 IV-1 10 Final Body Weight 241.8 23.2(19) 239.6 31.4(19) Liver 10.735 0.990(19) 10.406 1.804(19) Thyroid Gland 0.016 0.002(18) 0.018 0.003 (19) Uterus 0.474 0.160(19) 0.488 0.156(19) Brain 1.809 0.098(19) 1.813 0.088(19) VI-1 100 236.4 20.4(19) 10.032 1.062(19) 0.016 0.003(19) 0.487 0.125(19) 1.803 0.077(19) VIXI-1 1000 235.6 27.8(19) 9.859# 1.048(19) 0.016 0.004(19) 0.516 0.153(19) 1.790 0.080(19) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -458- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 81 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULT MEAN RELATIVE ORGAN WEIGHTS (% of body weight) Group: Dosage(mg/kg) II-l 0 XV-1 10 Liver/ Final Body * 100 4.449 0.267(19) 4.324 0.304(19) Thyroid Gland/ Final Body * 100 0.007 0.001(18) 0.008 0.002(19) Uterus/ Final Body * 100 0.198 0.072(19) 0.211 0.088(19) Brain/ Final Body * 100 0.752 0.050(19) 0.766 0.081(19) VI-1 100 4.246# 0.302(19) 0.007 0.002 (19) 0.207 0.054(19) 0.767 0.055(19) VIII-1 1000 4.199# 0.283(19) 0.007 0.002(19) 0.218 0.053(19) 0.768 0.076(19) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -459- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________DuPont-11418 TABLE 81 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - F, ADULT M E A N R E L A T I V E O R G A N W E IGHTS (% organ to b r a i n w e ights ratio) Group : Dosage (mg/kg) II-l 0 IV-1 10 VI-1 100 VIII-1 1000 Liver/ Brain * 100 593.399 42.559(19) 573.029 91.618(19) 556.621 56.505(19) 550.923# 55.195(19) Thyroid Gland/ Brain * 100 0.868 0.141(18) 1.018 0.199(19) 0.861 0.177(19) 0.898 0.204(19) Uterus/ Brain * 100 26.323 9.210(19) 27.100 9.514(19) 27.130 7.497(19) 28.827 8.551(19) Data summarized as: Mean Standard Deviation (n) # Statistically significant difference from control at p < 0.05 by Jonckheere-Terpstra trend test. Company Sanitized. Does not contain TSCA CBI -460- > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: SKIN ULCER/EROSION WHOLE BODY AUTOLYSIS TABLE 82 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Pi ADULTS GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: 1-0 0 20 III-O 10 20 V-0 100 20 VII-0 1000 20 0001 0 00 1 NOTE: INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -461 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: LIVER LARGE DISCOLORATION KIDNEYS DISCOLORATION SPLEEN LARGE THYMUS EDEMA VAGINA FLUID SKIN ALOPECIA TABLE 83 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Pi ADULTS GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: II-O . 0 20 IV-0 10 20 VI-0 100 20 VIII-0 1001 20 0100 1 000 0100 0100 0100 0 100 0110 NOTE: INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -462- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: MESENTERY DISCOLORATION KIDNEYS DILATATION TABLE 84 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Ft ADULTS GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: 1-1 0 25 III-l 10 19 V-l 100 24 VII-1 1000 23 0 01 0 0 002 NOTE: INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -463- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations S I T E /LESION: TABLE 85 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - F, ADULTS GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: II-l 0 25 IV-1 10 24 VI-1 100 24 VIII-1 1000 24 NO ABNORMALITIES DETECTED NOTE: INCIDENCES REFL E C T -THE N U M B E R OF ANIMALS WIT H A G I V E N LESION. DuPont-11418 Company Sanitized. Does not contain TSCA CBI -464- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 86 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS - P! ADULTS LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: 1-0 0 20 III-O 10 20 V-0 100 20 VII-0 1000 20 REPRODUCTIVE SYSTEM TESTES ONE OF PAIR NOT PRESENT EPIDIDYMIDES PROSTATE AGGREGATES, LYMPHOID SEMINAL VESICLES COAGULATING GLANDS ENDOCRINE SYSTEM PITUITARY GLAND THYROID GLAND OTHER CAUSE OF DEATH SACRIFICED BY DESIGN UNDETERMINED 1 - 1 1 1 (-,1 ,-,-,-) 1 1 0 - 0 0 - 0 0 00 00 1 1 (1,-,-,-,-) - 0 - 1 1 (1,-,-, -,-) 1 1 1 (-,1,-, -,-) 1 0 2 1 (1, -) 2 2 1 {-,-,1,-,-) 2 1 01 00 1 1 <1,-,- 2 1 (1, 1 (1. ,-) ,-) NOTES : THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". Company Sanitized. Does not contain TSCA CBI -465- ) ') H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 TABLE 87 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS - PI ADULTS L E S I O N GRADEfe TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (mg/kg): NUMBER IN GROUP: II-O 0 20 IV-0 10 20 VI-0 100 20 VIII-0 1000 20 REPRODUCTIVE SYSTEM OVARIES UTERUS VAGINA ESTRUS ESTRUS ESTRUS STAGE: STAGE: STAGE: ESTRUS METESTRUS PROESTRUS ENDOCRINE SYSTEM PITUITARY GLAND CYST THYROID GLAND OTHER CAUSE OF DEATH SACRIFICED BY DESIGN UNDETERMINED 1 1 1 - 1 (1, - 0 0 1 1 (1, - 1 1 1 - 1 1 <1,-, 1 1 (-,1, 1 1 ) 1 (1,-, 1 1 1 1 (1,-, -,-,-) - - 1 1 1 1 (1,-, - - 00 -- 00 1 1 (1,- ,-,-,-) - 1 1 (1,-, - NOTES: THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". Company Sanitized. Does not contain TSCA CBI - 466- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: KIDNEYS DILATATION TABLE 88 INCIDENCES OF GROSS OBSERVATIONS IN GENERATION FxMALE WEANLINGS DAM GROUP DESIGNATION: DOSE (mg/kg): NUMBER WEANLINGS/LITTERS: II-O 0 55/19 IV-0 10 53/19 VI-0 100 52/17 VIII-0 1000 57/19 0 ( 0) 0 ( 0) 1(1) 0 ( 0) TOTAL LITTERS AFFECTED TOTAL WEANLINGS AFFECTED 0010 0010 DuPont-11418 For each group: The count of weanlings only includes those which underwent pathological examination The count of litters only includes those in which weanlings underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of weanlings affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -467- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: KIDNEYS DILATATION WHOLE BODY SMALL TABLE 89 INCIDENCES OF GROSS OBSERVATIONS IN GENERATION Fj FEMALE WEANLINGS DAM GROUP DESIGNATION: DOSE (mg/kg): NUMBER WEANLINGS/LITTERS: II-O 0 56/19 IV-0 10 55/18 VI-0 100 49/17 VIII-0 1000 55/19 1 ( 1) 0 ( 0) 0 ( 0) 1 ( 1) 1 ( 1) 0 ( 0) 0 ( 0) 0 ( 0) TOTAL LITTERS AFFECTED TOTAL WEANLINGS AFFECTED 2 00 1 2001 ) DuPont-11418 For each group: The count of weanlings only includes those which underwent pathological examination. The count of litters only includes those in which weanlings underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of weanlings affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -468- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: STOMACH NO MILK SPOT LUNGS NOT EXPANDED WHOLE BODY SMALL AUTOLYSIS TABLE90 INCIDENCES OF GROSS OBSERVATIONS IN GENERATION FxMALE PUPS DAM GROUP DESIGNATION: DOSE (mg/kg): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 10 6/2 VI-0 100 1/1 VIII-0 1000 2/2 0 ( 0) 3 ( 2) 0 ( 0) 1 ( 1) 0 ( 0) 2 ( 1) 0 ( 0) 1 ( 1) 0 ( 0) 0 ( 0) 0 ( 0) 2 ( 1) 0 ( 0) 0 ( 0) 1 ( 1) 1 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0202 0 502 DuPont-11418 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -469- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION STOMACH NO MILK SPOT LUNGS NOT EXPANDED SKULL HEMORRHAGE TABLE 91 INCIDENCES OF GROSS OBSERVATIONS IN GENERATION F! FEMALE PUPS DAM GROUP DESIGNATION: DOSE (mg/kg): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 10 1/1 VI-0 100 2/1 VIII-0 1000 1/1 0) 1 ( 1) 1 ( 1) 0 ( 0) 0 ( 0) 1 ( 1) 1 ( 1) 0 ( 0) 0 ( 0) 0 ( 0) 1 ( 1) 0 ( 0) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0110 0120 DuPont-11418 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -470- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 92 INCIDENCES OF GROSS OBSERVATIONS IN GENERATION Fj UNSEXABLE PUPS SITE/LESION: NO UNSEXED PUPS TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED *DAM GROUP DESIGNATION: DOSE (mg/kg): NUMBER PUPS/LITTERS: II-O 0 0/0 0 0 IV-0 10 0/0 0 0 VI-0 100 0/0 0 0 VIII-0 1000 0/0 0 0 DuPont-11418 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -471 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURES -472- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURES EXPLANATORY NOTES Critical Dates Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subchronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. -473- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 1 MEAN BODY WEIGHTS OF MALE RATS DuPont-11418 0 mg/kg/day 0--10 mg/kg/day &--100 mg/kg/day X--1000 mg/kg/day Company Sanitized. Does not contain TSCA CBI -474- )> ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________DuPont-11418 FIGURE 2 MEAN BODY WEIGHTS OF FEMALE RATS 0 mg/kg/day --0 --10 mg/kg/day --A--100 mg/kg/day - X 1000 mg/kg/day Days on Test - 475- Company Sanitized. Does not contain TSCA C8I )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ FIGURE 3 MEAN FORELIMB GRIP STRENGTH FOR MALE RATS 2.50 -, ) DuPont-11418 2.00 b bU 1.50 G <u cn Cu 4C o ao 6 1.00 <D COL, 0.50 0.00 Assessment Period Error bars represent the standard deviation. 0 mg/kg/day IB 10mg/kg/day M 100 mg/kg/day M 1000 mg/kg/day Company Sanitized. Does not contain TSCA CBI --- 1 -4 7 6 - Recovery H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations 1.80 ! 1.60 - 1.40 - tw 1.20 - JC 4t-u4o 1 1.00 - os a. 0.80 - x> S FIGURE 4 MEAN FORELIMB GRIP STRENGTH FOR FEMALE RATS DuPont-11418 0mg/kg/day H 10 mg/kg/day U 100 mg/kg/day 1000 mg/kg/day Company Sanitized. Does not contain TSCA Baseline Week 13 Assessment Period Recovery O Error bars represent the standard deviation. 03 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURE 5 MEAN H3NDLIMB GRIP STRENGTH FOR MATH RATS 1.20 n 1.00 W) g 0.80 W) a s oo a, 0.60 S 0.40 0.20 0.00 Baseline Week 13 Assessment Period Error bars represent the standard deviation. I 0 mg/kg/day H 10 mg/kg/day 100 mg/kg/day B 1000 mg/kg/day Company Sanitized. Does not contain TSCA CBI 478 1 Recovery H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Hindlimb GripStrength (kg) FIGURE 6 MEAN HINDLIMB GRIP STRENGTH FOR FEMALE RATS 0.80 0.70 0.60 0.50 0.40 0.30 0.20 0.10 0.00 Baseline Week 13 Assessment Period Error bars represent the standard deviation. I Recovery DuPont-11418 BO mg/kg/day B 10 mg/kg/day B 100 mg/kg/day H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURE 7 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL DURATION OF MOVEMENT FOR MALE RATS Company Sanitized. Does not contain TSCA CBI Assessment Period Error bars represent the standard deviation. 480 IOOmg/kg/day H 10 mg/kg/day H 100 mg/kg/day M 1000 mg/kg/day Recovery --- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-11418 FIGURE 8 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL DURATION OF MOVEMENT FOR FEMALE RATS 2500 -, 2000 - Company Sanitized. Does not contain TSCA CBI Week 13 Assessment Period Error bars represent the standard deviation. 481 0 mg/kg/day IB 10mg/kg/day B 100 mg/kg/day M1000 mg/kg/day Recovery H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURE 9 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL NUMBER OF MOVEMENTS FOR MAT E RATS 1000 i 900 800 700 G 600 - <o >o 500 - <U "ag 400 Z 0 mg/kg/day B 10 mg/kg/day B 100 mg/kg/day 1000 mg/kg/day Company Sanitized. Does not contain TSCA CBI Baseline W eek 13 Assessment Period Error bars represent the standard deviation. -482- Recovery H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 FIGURE 10 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL NUMBER OF MOVEMENTS FOR FEMALE RATS Company Sanitized. Does not contain TSCA CBI 0 mg/kg/day B 10 mg/kg/day B 100 mg/kg/day M 1000 mg/kg/day Baseline Week 13 Assessment Period Error bars represent the standard deviation. -483- Recovery H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDICES -484- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction valuations______________________DuPont-11418 APPENDICES EXPLANATORY NOTES Critical Dates Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subchronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. Abbreviations mg/kg = mg/kg/day g/anm/day = grams/animal/day Note Absence of data indicates the animal was not alive at the time of data collection; NM (not measured) may be reported if an animal died on the day of a scheduled weighing. -485 - Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX A ANALYTICAL DATA -486- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Table I. Recovery of H-25425 Added to Dosing Vehicle Sample mg/ml H-25425 Percent Type Nominal Measured Nominal RecoveryTM 1.96 1.48 75.5 Recovery 2.17 1.61 74.2 Recovery 2.70 1.85 68.5 Recovery 2.45 1.92 78.4 Mean 74.24.2, c.v. 6% RecoveryTM Recovery Recovery 19.1 16.4 85.9 19.4 17.1 88.1 20.7 17.4 84.1 Mean 86.0 2.0, C.V. 2% RecoveryTM 189 175 92.6 Recovery 198 191 96.5 Recovery 192 171 89.1 Mean 92.8 3.7, C .V .4 % <A> Processed with homogeneity/concentration verification samples from dosing prepared on test day 2 (October 17,2002). <B) Processed with homogeneity/concentration verification samples from dosing prepared on test day 8 (October 23,2002). (C) Processed with concentration verification samples from dosing prepared on test day 42 (November 26, 2002). Processed with concentration verification samples from dosing prepared on test day 86 (January 9,2003). -487- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Table II. Homogeneity/Concentration Verification and Stability of H-25425 in Dosing Suspensions Sample mg/mL H-25425 Percent __T__esTtjdpaey 2 Nominal Measured Nominal Homoaeneitv Control Top M eddle B ottom Top M iddle B ottom Top M iddle B ottom 0.00 2.00( ) 2.00( ) 2.00( ) 20.0( ) 20.0( ) 20.0( ) 200 200 200 n d (A ) 1.36 1.87 2.00 MeaniO: 1.74 + 0.34 C.V. 19% 19.0 20.8 21.3 Mean(Q: 20.4 1 .2 C.V. 6% 187 188 191 MeaniQ: 189 + 2.1 C.V. 1% ___ 68.0 93.5 100.0 (87.0% ) 95.0 104.0 106.5 (102.0% ) 93.5 94.0 95.5 (94.5% ) 5 HOUR(d) Test day 9 Homoaeneitv 2.00( ) 20.0( ) 200 1.83 21.7 196 91.5 108.5 98.0 Control Top M iddle B ottom 0.00 2.00( ) 2.00( ) 2.00( ) MeaniO: n d (A ) 1.87 1.97 1.91 1.92 0.05 C.V. 2% 93.5 98.5 95.5 (96.0%) Denotes not detected. (B> All reported results corrected based on recovery of the spiked sample (refer to Table I). <C) The average measured concentration, average percent of nominal (in parentheses), standard deviation, and coefficient of variation of top, middle, and bottom. (D) Stability samples held 5 hours a room temperature. -488 - Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Table III. Concentration Verification of H-25425 in Dosing suspensions Preparation Day mg/mL H-25425 Sample Type Nominal Measured Test day 42 Concentration Verification^ Control 0.0 n d (b ) 2.00- 1(C) 2.00- 2(Q Mean<P): 2.35 2.36 2.36 0.10 C. V. 0.4% 20.0-1(0 20.0-1(0 MeanP): 20.5 20.8 20.7 0.16 C.V. 1% 200-1 200-2 M eanV ); 190 193 192 2.1 C.V. 1% Percent Nominal 117.5 118.0 (118.0) 102.5 104.0 (103.5) 95.0 96.5 (96.0) Test day 86 Concentration Verification^) Control 0.0 n d (b ) 2.00-1(0 2.00-2(0 M eanP): 2.03 2.04 2.04 0.01 C.V. 0.5% 101.5 102.0 (102.0) 20.0-1(0 20.0-KQ MeantP): 19.6 21.8 20.7 1.5 C.V. 7% 98.0 109.0 (103.5) 200-1(0 209 104.5 200-1(0 203 101.5 MeanP): 206 4.0 (103.0) C.V. 2% Duplicate samples per level were analyzed. Mean, S.D. and C.V. calculated to verify uniformity of mixture. (B) Denotes not detected. (C) All reported results corrected based on recovery of the spiked sample (refer to Table I). <D) Mean result for analyses on duplicate samples. -489- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Figure 1 Representative Analytical Calibration Curves DuPont-11418 Concentration, mg/mL Figure la: Calibration curve showing linear fit (line) to replicate peak height measurements (squares) for calibration solutions of H-25425 diluted with THF over a concentration range of 1.897 to 8.672 mg/mL. -490- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Figure 2 Representative HPLC/GPC/RI Chromatography Chromatograms DuPont-11418 Figure 2a: Representative HPLC/GPC/RI chromatogram of 0.00 mg/mL dosing suspension of H-25425. Figure 2b: RoefpHre-s2e5n4t2a5ti.ve HPLC/GPC/RI chromatogram of 5.962 mg/mL analytical reference solution -491 - Com pany S a n itiz e d . D oes n o t contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genration Reproduction Evaluations______________________ DuPont-11418 Figure 2 (continued) Representative HPLC/GPC/RI Chromatography Chromatograms Figure 2c: Representative HPLC/GPC/RI chromatogram of 200 mg/mL dosing suspension diluted to nominal concentration of 6.00 mg/mL of H-25425. The measured concentration o f the representative solution is 190 mg/mL. Figure 2d: Representative HPLC/GPC/RI chromatogram of 198 mg/mL spiked dosing suspension diluted to nominal concentration of 6.00 mg/mL of H-25425. The measured concentration of the representative solution is 193 mg/mL. -492- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX B INDIVIDUAL DOSE VOLUMES -493 - Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL DOSE VOLUMES EXPLANATORY NOTES Critical Dates Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subchronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. Abbreviations mg/kg = mg/kg/day Note Absence of data indicates the animal was not alive at the time of data collection. -494- Com pany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: tale INDIVIDUAL DOSE VOLUMES Gavage ml Day 0 Male, I 0 mg/kg Gavage . Gavage ml ml Day 1 Day 2 Gavage ml Day 3 Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 665047 665049 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 665070 665130 665076 1.4 1.2 1.1 1.4 1.2 1.1 1.4 1.2 1.1 1.4 1.2 1.1 1.4 1.2 1.1 1.4 1.4 1.2 1.2 1.1 ` 1.1 665015 665068 665148 665016 665086 665023 665072, 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 1.2 1.3 1.3 1.3 1.0 1.2 1.2 1.2 1.3 1.2 1.2 1.2 1.2 1.0 1.2 l.l 1.2 1.2 1.1 1.2 1.2 1.2 1.3 1.1 l.l 1.2 1.3 1.2 l.l 1.2 l.l 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.0 1.0 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.0 1.0 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1,2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.1 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.0 1.2 1.2 1.2 1.3 1.2 1.2 1.2 1.2 1.0 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.2 1.3 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.1 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.0 1.0 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.0 1.0 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 NM 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.1 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.0 1.2 1.2 1.2 1.3 1.2 1.2 1.2 1.2 1.0 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.2 1.3 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.1 1.2 1.2 Key: NM = Not Measurable; error in recording dose volume in database but rat DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.8 1.8 1.8 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 . 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 believed to have received correct dose volume. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 0 Male, I 0 mg/kg 665081 665159, 665043 665064 665121 665106 665008 1.2 1.2 1.2 1.2 1.2 1.3 1.3 le Gavage ml Day 1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 Gavage ml Day 2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 Gavage ml Day 3 1.2 1.2 1.2 1.2 1.2 1.3 1.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1-3 1.3 1.3 1.3 1.3 -496- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 0 Gavage ml Day 1 Male, III: 10 mg/kg 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 1.2 1.3 1.3 1.2 1.1 1.1 1.2 1.3 1.3 1.1 1.1 1.2 1.1 1.2 1.1 1.2 1.2 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.2 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.3 1.3 1.2 1.1 1.1 1.2 1.3 1.3 1.1 1.1 1.2 1.1 1.2 1.1 1.2 1.2 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.2 1.1 1.2 1.3 1.2 1.1 1.2 Gavage ml Day 2 1.2 1.3 1.3 1.2 1.1 1.1 1.2 1.3 1.3 1.1 1.1 1.2 1.1 1.2 1.1 1.2 1.2 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.2 1.2 1.1 1.3 > 1.2 1.1 1.2 1.3 1.2 1.1 1.2 Gavage ml Day 3 1.2 1.3 1.3 1.2 1.1 1.1 1.2 1.3 1.3 1.1 1.1 1.2 1.1 1.2 1.1 1.2 1.2 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.2 1.1 1.2 1.3 1.2 1.1 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.3 1.3 1.3 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.2 1.1 1.1 1.1 1.2 1.2 1.2 -497- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1-5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1 .'5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1-5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 H-25425: Subchronic Toxicity Jffl-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 0 Gavage ml Day 1 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143. 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 Gavage ml Day 2 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 Gavage ml Day 3 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 Gavage ml Day 4 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 Gavage ml Day 5 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 Gavage ml Day 6 1.2 1.2 1.4 1.2 1.1 1.1 1.2 1.3 1.2 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.2 1.1 1.2 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.2 1.3 1.3 1.1 1.2 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.5 1.5 1.5 1.5 1.5 1..5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.-5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 0 Gavage ml Day 1 Male, VII 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018' 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 ' 1.3 1.2 1.3 1.2 1.2 1.1 1.2 1.3 1.3 1.2 1.1 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.1 1.2 1.1 1.2 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.3 1.3 1.3 1.1 1.2 1.1 1.3 1.2 1.3 1.2 1.3 1.2 1.2 1.1 1.2 1.3 1.3 1.2 1.1 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.1 1.2 1.1 1.2 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.3 1.3 1.3 1.1 1.2 1.1 1.3 1.2 Gavage ml Day 2 1.3 1.2 1.3 1.2 1.2 1.1 1.2 1.3 1 -3 1.2 1.1 1.2 1.1 1.3 1.1 1.2 1.2 1.2 1.1 1.2 1.1 1.2 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.1 1.3 1.3 1.3 1.1 1 1.2 1.1 1.3 1.2 ige Gavage ml 3 Day 4 Gavage ml Day 5 Gavage ml Day 6 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 7 Gavage ml Day 8 Gavage Gavage ml ml Day 9 s Day 10 Gavage ml Day 11 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1-5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: [male Gavage ml Day 0 Gavage ml Day 1 Male, VII: 1000 mg/kg 665095 1.2 1.2 665031 1.2 1.2 665146 1.2 1.2 665062 1.2 1.2 665138 1.1 1.1 665112 1.3 1.3 665007 1.3 1.3 Gavage ml Day 2 1.2 1.2 1.2 1.2 1.1 1.3 1.3 Gavage ml Day 3 1.2 1.2 1.2 1.2 1.1 1.3 1.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.3 -500- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.4 1.4 1.4 1.4 1. 1.5 1.5 1.5 1.5 1. 1.5 1.5 1.5 1.5 1. 1.5 1.5 1.5 1.5 1. 1.3 1.3 1.3 1.3 1. 1.5 1.5 1.5 1.5 1. 1.6 1.6 1.6 1.6 1. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory StudyiJ b s Gavage ml Day 12 jnale Gavage ml Day 13 Male, I 0 mg/kg 665047665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021' 665087 665079 665042 665098 665149 1.5 1.5 1.8 1.5 1-.4 1.5 1.6 1.6 1.5 1.3 1.5 1.4 1.4 1.5 1.5 1.5 1.5 1.4 1.3 1.4 1.5 1.4 1.5 1.4 1.5 1.5 1.5 1.6 1.4 1.3 1.5 1.6 1.5 1.3 1.6 1.4 1.5 1.6 1.5 1.5 1.8 1.5 1.4 1.5 1.6 1.6 1.5 1.3 1.5 1.4 1.4 1.5 1.5 1.5 1.5 1.4 1.3 1.4 1.5 1.4 1.5 1.4 1.5 1.5 1.5 1.6 1.4 1.3 1.5 1.6 1.5 1.3 1.6 1.4 1.5 1.6 Gavage ml Day 14 1.7 1.7 2.0 1.9 1.6 1.9 1.8 1.9 1.7 1.5 1.8 1.7 1.7 1.8 1.7 1.8 1.6 1.6 1.5 1.7 1.7 1.6 1.8 1.6 1.7 1.7 1.7 1.9 1.6 1.6 1.7 1.8 1.7 1.5 1.8 1.6 1.7 1.8 Gavage ml Day 15 1.7 1.7 2.0 1.9 1.6 1.9 1.8 1.9 1.7 1.5 1.8 1.7 1.7 1.8 1.7 1.8 1.6 1.6 1.5 1.7 1.7 1.6 1.8 1.6 1.7 1.7 1.7 1.9 1.6 1.6 1.7 1.8 1.7 1.5 1.8 1.6 1.7 1.8 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 1.7 1.7 1.7 1.7 1.7 1.7 2.0 2.0 2.0 1.9 1.9 1.9 1.6 1.6 1.6 1.9 1.9 1.9 1.8 1.8 1.8 1.9 1.9 .1.9 1.7 1.7 1.7 1.5 1.5 1.5 1.8 1 -8 1.8 1.7 1.7 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.7 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.8 1.8 1.8 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.8 1.8 1.8 1.7 1.7 1.7 1.5 1.5 1.5 1.8 1.8 1.8 1.6 1.6 1.6 1.7 1.7 1.7 1.8 1.8 1.8 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 2.0 2.0 2.2 2.2 2.2 1.9 1.9 2.1 2.1 2.1 1.6 1.6 1.8 1.8 1.8 1.9 1.9 2.1 2.1 2.1 1.8 1.8 2.1 2.1 2.1 1.9 1.9 2.1 2.1 2.1 1.7 1.7 1.8 1.8 1.8 1.5 1.5 1.8 1.8 1.8 1.8 1.8 2.1 2.1 2.1 1.7 1.7 2.0 2.0 2.0 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.7 1.7 2.0 2.0 2.0 1.6 1.6 1.8 1.8 1.8 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.7 1.7 1.7 1.7 1.7 2.0 2.0 2.0 1.7 1.7 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.9 1.9 2.2 2.2 2.2 1.6 1.6 1.9 1.9 1.9 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.7 1.7 1.8 1.8 1.8 1.5 1.5 1.7 1.7 1.7 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.1 2.1 2.1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 12 Male, I 0 mg/kg 665081 665159 665043 665064 665121 665106 665008 1.5 1.5 1.5 1.4 1.4 1.6 1.6 Gavage ml Day 13 1.5 1.5 1.5 1.4 1.4 1.6 1.6 Gavage ml Day 14 1.7 1.8 1.7 1.7 1.6 1.8 1.8 Gavage ml Day 15 1.7 1.8 1.7 1.7 1.6 1.8 1.8 Gavage ml Day 16 1.7 1.8 1.7 1.7 1.6 1.8 1.8 Gavage ml Day 17 1.7 1.8 1.7 1.7 1.6 1.8 1.8 Gavage ml Day 18 1.7 1.8 1.7 1.7 1.6 1.8 1.8 -502- DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.7 1.7 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study : naie Gavage ml Day 12 Gavage ml Day 13 Male, III 10 m g / k g 665053 665074 665128 665080 664993 665131 665060' 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 66505.6 665025 665038 665006 665167 665020 1.5 1.6 1.6 1.5 1.4 1.4 1.5 1.5 1.6 1.4 1.3 1.5 1.4 1.5 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.3 1.5 1.4 1.4 1.5 1.5 1.3 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.6 1.5 1.4 1.4 1.5 1.5 1.6 1.4 1.3 1.5 1.4 1.5 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.3 1.5 1.4 1.4 1.5 1.5 1.3 1.5 1.6 1.5 1.3 1.5 Gavage ml Day 14 1.7 1.8 1.8 1.8 1.6 1.6 1.8 1.7 1.8 1.6 1.4 1.7 1.6 1.7 1.4 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.7 1.5 1.7 1.6 1.5 1.8 1.8 1.5 1.7 1.8 1.7 1.5 1.7 Gavage ml Day 15 1.7 1.8 1.8 1.8 1.6 1.6 1.8 1.7 1.8 1.6 1.4 1.7 1.6 1.7 1.4 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.7 1.5 1.7 1.6 1.5 1.8 1.8 1.5 1.7 1.8 1.7 1.5 1.7 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.6 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.6 1.4 1.4 1.4 1.7 1.7 1.7 1.6 1.6 1.6 1.7 1.7 1.7 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.5 1.5 1.5 1.7 1.7 1.7 1.6 1.6 1.6 1.5 1.5 1.5 1.8 1.8 1.8 1.8 1.8 1.8 1.5 1.5 1.5 1.7 1.7 1.7 1.8 1.8 1.8 1.7 1.7 1.7 1.5 1.5 1.5 1.7 1.7 1.7 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.7 1.7 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.0 2.0 2.0 1.6 1.6 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.8 1.8 1.8 1.4 1.4 1.5 1.5 1.5 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.4 1.4 1.6 1.6 1-6 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.8 1.6 1.6 1.7 1.7 1.7 1.6 1.6 1.7 1.7 1.7 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.5 1.5 1.7 1.7 1.7 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.5 1.5 1.6 1.6 1.6 1.7 1.7 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 H-25425: Subchronic Toxicity 9 0 - D a y a g e Study in Rats with^One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: iale Gavage ml Day 12 Gavage ml Day 13 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140. 665114 665139 665111 665055 665066 665039 665003 665088 665147 1.5 1.5 1.7 1.5 1.4 1.4 1.5 1.6 1.4 1.3 1.4 1.5 1.5 1.6 1.5 1.4 1.5 1.5 1.4 1.5 1.5 1.4 1.6 1.4 1.5 1.4 1.5 1.5 1.5 1.4 1.4 1.6 1.6 1.3 1.5 1-5 1.5 1.7 1.5 1.4 1.4 1.5 1.6 1.4 1.3 1.4 1.5 1.5 1.6 1.5 1.4 1.5 1.5 1.4 1.5 1.5 1.4 1.6 1.4 1.5 1.4 1.5 1.5 1.5 1.4 1.4 1.6 1.6 1.3 1.5 Gavage ml Day 14 1.7 , 1.8 2.0 1.6 1.5 1.6 1.7 1.9 1.6 1.5 1.6 1.7 1.8 1.8 1.8 1.6 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.5 1.7 1.6 1.7 1.7 1.7 1.7 1.6 1.8 1.8 * 1.4 1.7 Gavage ml Day 15 1.7 1.8 2.0 1.6 1.5 1.6 1.7 1.9 1.6 1.5 1.6 1.7 1.8 1.8 1.8 1.6 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.5 1.7 1.6 1.7 1.7 1.7 1.7 1.6 1.8 1.8 1.4 1.7 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 1.7 1.7 1.7 1.8 1.8 1.8 2.0 2.0 2.0 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6 1.6 1.7 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.6 1.5 1.5 1.5 ' 1.6 1.6 1.6 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.6 1.6 1.6 1.8 1.8 1.8 1.5 1.5 1.5 1.7 1.7 1.7 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.8 1.8 1.8 1.8 1.8 1.8 1.4 1.4 1.4 1.7 1.7 1.7 -504- ( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage it. Day 21 Gavage ml tDay 22 Gavage ml Day 23 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.3 1.6 1.6 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.9 1.9 2.1 2.1 2.1 1.6 1.6 1.8 1.8 1.8 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.7 1.7 1.7 1.7 1.7 2.0 2.0 2.0 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.7 1.7 1.7 1.8 1.8 2.1 2.1 2.1 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.8 1-8 1.8 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.4 1.4 1.6 1.6 1.6 1.7 1.7 1.9 1.9 1.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generalion Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 12 Gavage ml Day 13 Male, VII: 1000 mg/kg Gavage ml Day 14 Gavage ml Day 15 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118, 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 1.6 1.6 1.8 1.5 1.5 1.7 1.5 1.5 1.8 1.5 1.5 1.7 1.4 1.4 1.7 1.4 1.4 1.5 1.4 1.4 1.7 1.5 1.5 1.8 1.5 1.5 1.8 1.4 1.4 1.6 1.3 1.3 1.5 1.5 1.5 1.7 1.4 1.4 1.5 1.5 1.5 1.8 1.4 1.4 1.5 1.5 1.5 1.7 1.5 1.5 1.7 1.4 1.4 1.5 1.3 1.3 1.5 1.4 1.4 1.6 1.4 1.4 , 1.6 1.4 1.4 1.6 1.5 1.5 1.7 1.3 1.3 1.5 1.5 1.5 1.7 1.5 1.5 1.8 1.5 1.5 1.8 1.5 1.5 1.8 1.5 1.5 1.7 1.3 1.3 1.6 1.5 1.5 1.8 1.5 1.5 1.8 1.5 1.5 1.8 1.3 1.3 1.5 1.5 1.5 1.7 1.4 1.4 1.5 1.5 1.5 1.8 1.4 1.4 1.7 1.8 1.7 1.8 1.7 1.7 1.5 1.7 1.8 1.8 1.6 1.5 1.7 1.5 1.8 1.5 1.7 1.7 1.5 1.5 1.6 1.6 1.6 1.7 1.5 1.7 1.8 1.8 1.8 1.7 1.6 1.8 1.8 1.8 1.5 1.7 1.5 1.8 1.7 .Key: N M = N o t Measurable; partial dose given Gavage ml Day 16 1.8 1.7 1.8 1.7 1.7 1.5 1.7 1.8 1.8 1.6 1.5 1.7 1.5 1.8 1.5 1.7 1.7 1.5 1.5 1.6 1.6 1.6 1.7 1.5 1.7 1.8 1.8 1.8 1.7 1.6 1.8 1.8 1.8 1.5 1.7 1.5 1.8 1.7 Gavage ml Day 17 1.8 1.7 1.8 1.7 1.7 1.5 1.7 1.8 1.8 1.6 1.5 1.7 1.5 1.8 1.5 1.7 1.7 1.5 1.5 1.6 1.6 1.6 1.7 1.5 1.7 1.8 1.8 1.8 1.7 1.6 1.8 1.8 1.8 1.5 1.7 1.5 1.8 1.7 Gavage ml Day 18 1.8 1.7 1.8 1.7 1.7 1.5 1.7 1.8 1.8 1.6 1.5 1.7 1.5 1.8 1.5 1.7 1.7 1.5 1.5 1.6 1.6 1.6 1.7 1.5 1.7 . 1.8 1.8 1.8 1.7 1.6 1.8 1.8 1.8 1.5 1.7 1.5 1.8 1.7 -505- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.8 1.8 2.1 2.1 2.1 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1-8 1.8 1.9 1.9 1.9 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.5 1.5 1.8 NM 1.8 1.8 1.8 2.0 2.0 2.0 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.5 1.5 1.7 1.7 1.7 1.6 1.6 1.8 1.8 1.8 1.6 1.6 1.8 1-8 1.8 1.6 1.6 1.9 1.9 1.9 1.7 1.7 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.6 1.6 1.8 1.8 1.8 1.8 1.8 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.5 1.5 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 1.7 1.7 1.9 1.9 1.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 12 Gavage ml Day 13 Male, VII! 1000 mg/kg 665095' 665031 665146 665062 665138 665112 665007 1.4 1.5 1.5 1.5 1.3 1.5 1.6 1.4 1.5 1.5 1.5 1.3 1.5 1.6 Gavage ml Day 14 1.6 1.7 1.7 1.7 1.5 1.8 1.8 Gavage ml Day 15 1.6 1.7 1.7 1.7 1.5 1.8 1.8 Gavage ml Day 16 1.6 1.7 1.7 1.7 1.5 1.8 1.8 Gavage ml Day 17 1.6 1.7 1.7 1.7 1.5 1.8 1.8 Gavage ml Day 18 1.6 1.7 1.7 1.7 1.5 1.8 1.8 -506- c Company Sanitized. Does not contain TSCA CBI DuPont-11418 Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.6 1.6 1.8 1.8 1.8 1.7 1.7 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.7 1.7 2.0 2.0 2.0 1.5 1.5 1.7 1.7 1.7 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 ( H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 24 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141' 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 1.9 1.9 2.2 2.1 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.0 1-9 2.0 2.0 2.1 1.9 1.8 1.7 1.9 2.0 1.8 2.1 1.7 2.0 1.8 1.9 2.2 1.9 1.7 1.9 2.0 1.8 1.7 2.1 1.7 1.9 2.1 rale Gavage ml Day 25 1.9 1.9 2.2 2.1 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.0 1.9 2.0 2.0 2.1 1.9 1.8 1.7 1.9 2.0 1.8 2.1 1.7 2.0 1.8 1.9 2.2 1.9 1.7 1.9 2.0 1.8 1.7 2.1 1.7 1.9 2.1 Gayage ml Day 26 1.9 1.9 2.2 2.1 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.0 1.9 2.0 2.0 2.1 1.9 1.8 1.7 1.9 2.0 1.8 2.1 1.7 2.0 1.8 1.9 2.2 1-9 1.7 1.9 2.0 1.8 1.7 2.1 1.7 1.9 2.1 Gavage ml Day 27 1.9 1.9 2.2 2.1 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.0 1.9 2.0 2.0 2.1 1.9 1.8 1.7 1.9 2.0 . 1.8 2.1 1.7 2.0 1.8 1.9 2.2 1.9 1.7 1.9 2.0 1.8 1.7 2.1 1.7 1.9 2.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 2.0 2.0 2.0 2.1 2.1 2.1 2.4 2.4 2 .4 2.3 2.3 2.3 2.0 2.0 2.0 2.3 2.3 2.3 2.2 2.2 2.2 2.4 2.4 2.4 2.0 2.0 2.0 1.9 1.9 1.9 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.2 2.0 2.0 2.0 2.0 2.0 2.0 1.8 1.8 1.8 2.1 2.1 2.1 2.2 2.2 2.2 2.0 2.0 2.0 2.3 2.3 2.3 1.9 1.9 1.9 2.1 2.1 2.1 2.0 2.0 2.0 2.1 2.1 2.1 2.4 2.4 2.4 2.1 2.1 2.1 1.9 1.9 1.9 2.1 2.1 2.1 2.2 2.2 2.2 2.0 2.0 2.0 1.9 1.9 1.9 2.3 2.3 2.3 1.9 1.9 1.9 2.0 2.0 2.0 2.2 2.2 2.2 -507- DuPont-11418 Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 2.0 2 . 0 2.0 2 . 0 2.1 2.1 2.1 2.1 2.1 2.2 2.4 2.4 2.4 2.4 2.7 2.3 2.3 2.3 2.3 2.5 2.0 2 . 0 2.0 2.0 2.1 2.3 2.3 2.3 2.3 2.4 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.5 2.0 2.0 2.0 2.0 2.1 1.9 1.9 1.9 1.9 2.1 2.2 2.2 2.2 2.2 2.4 2.1 2.1 2.1 2.1 2.3 2.1 2.1 2.1 2.1 2.2 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.2 2.2 2.2 2.2 2.3 2 . 0 2.0 2.0 2.0 2.2 2.0 2.0 2.0 2.0 2.1 1.8 1.8 1.8 1.8 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.1 2.3 2.3 2.3 2.3 2.5 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.3 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.2 2.4 2.4 2.4 2.4 2.5 2.1 2.1 2.1 2.1 2.2 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.3 2.0 2.0 2.0 2.0 2.1 1.9 1.9 1.9 1.9 2.0 2.3 2.3 2.3 2.3 2.5 1.9 1.9 1.9 1.9 2.0 2. 12.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.4 Company Sanitized. Does not contain CO o < o CD I- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: jale Gavage ml Day 24 Gavage ml Day 25 Male, I 0 mg/kg 665081 665159 665043 665064 665121 665106. 665008 1.8 2.0 2.0 1.9 1.8 2.0 2.1 1.8 2.0 2.0 1.9 1.8 2.0 2.1 Gavage .ml Day 26 1.8 2.0 2.0 1.9 1.8 2.0 2.1 Gavage ml Day 27 1.8 2.0 2.0 1.9 1.8 2.0 2.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.0 2.0 2.0 2.2 2.2 2.2 2.3 2.3 2.3 -508- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 2.0 2.0 2.2 2.2 22 .. 22 22 .. 02 2.2 2 . 0 2.1 2.2 2.3 2.2 2.3 2.1 2.1 2.1 2.1 2 . 2 2 . 0 2 . 0 2.0 2 . 0 2.2 2 . 2 2 . 2 2.2 2 . 2 2.4 2.3 2.3 2.3 2.3 2.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 24 Gavage ml Day 25 Male, III 10 mg/kg 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 . 665126 665125 665017 665071 665032 664997' 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 2.0 2.1 2.1 2.0 1.8 1.8 2.0 2.0 2.1 1.8 1-5 1.9 1.7 1.9 1.6 1.9 1.9 1.8 1.8 1.7 1.7 1.8 1.9 1.7 1.9 1.8 1.7 2.0 2.1 1.6 1.8 2.0 2.0 1.7 1.9 2.0 2.1 2.1 2.0 1.8 1.8 2.0 2.0 2.1 1.8 1.5 1.9 1.7 1.9 1.6 1.9 1.9 1.8 1.8 1.7 1.7 1.8 1.9 1.7 1.9 1.8 1.7 2.0 2.1 1.6 1.8 2.0 2.0 1.7 1.9 Gavage ml Day 26 2.0 2.1 2.1 2.0 1.8 1.8 2.0 2.0 2.1 1.8 1.5 1.9 1.7 1.9 1.6 1.9 1.9 1.8 1.8 1.7 1.7 1.8 1.9 1.7 1.9 1.8 1.7 2.0 2.1 1.6 1.8 2.0 2.0 1.7 1.9 Gavage ml Day 27 2.0 2.1 2.1 2.0 1.8 1.8 2.0 2.0 2.1 1.8 1.5 1.9 1.7 1.9 1.6 1.9 1.9 1.8 1.8 1.7 1.7 1.8 1.9 1.7 1.9 1.8 1.7 2.0 2.1 1.6 1.8 2.0 2.0 1.7 1.9 Gavage ml Day 28 2.2 2.3 2.3 2.2 1.9 2.0 2.2 2.1 2.3 1.9 1.7 2.1 1.9 2.0 1.8 2.1 2.1 2.0 2.0 1.9 1.9 2.0 2.1 1.9 2.2 2.0 1.9 2.2 2.3 1.8 2.0 2.2 2.1 1.9 2.1 Gavage ml Day 29 2.2 2.3 2.3 2.2 1.9 2.0 2.2 2.1 2.3 1.9 1.7 2.1 1.9 2.0 1.8 2.1 2.1 2.0 2.0 1.9 1.9 2.0 2.1 1.9 2.2 2.0 1.9 2.2 2.3 1.8 2.0 2.2 2.1 1.9 2.1 Gavage ml Day 30 2.2 2.3 2.3 2.2 1.9 2.0 2.2 2.1 2.3 1.9 1.7 2.1 1.9 2.0 1.8 2.1 2.1 2.0 2.0 1.9 1.9 2.0 2.1 1.9 2.2 2.0 1.9 2.2 2.3 1.8 2.0 2.2 2.1 1.9 2.1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 2.2 2.2 2.2 2 . 2 2.3 2.3 2.3 2.3 2.3 2.4 2.3 2.3 2.3 2.3 2.4 2.2 2.2 2.2 2 . 2 2.3 1.9 2.0 1.9 2.0 1.9 2.0 1.9 2.0 22.. 10 2.2 2 . 2 2.2 2.2 2.3 2.1 2.1 2.1 2.1 2.2 2.3 2.3 2.3 2.3 2.4 1.9 1.9 1.9 1.9 2.1 1.7 1.7 1.7 1.7 1.7 2.1 2.1 2.1 2.1 2 . 2 1.9 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.1 1.8 1.8 1.8 1.8 1.9 2.1 2.1 2.1 2.1 2.2 2.1 2.1 2.1 2.1 2 . 2 2.0 2 : 0 2.0 2.0 2.1 2.0 2 . 0 2.0 2.0 2.1 1.9 1.9 1.9 1.9 2.0 1.9 1.9 1.9 1.9 2.0 2.0 2 . 0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 2.2 1.9 1.9 1.9 1.9 2.0 2.2 2.2 2.2 2.2 2.3 2 . 0 2.0 2 . 0 2.0 2.1 1.9 1.9 1.9 1.9 1.9 2 . 2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.5 1.8 1.8 1.8 1.8 1.9 2.0 2.0 2 . 0 2.0 2.1 2.2 2.2 2.2 2.2 2.3 2.1 2.1 2.1 2.1 2.2 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 24 Gavage ml Day 25 Male, v 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028' 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 1.9 2.0 2.3 1.9 1.7 1.8 1.9 2.1 1.8 1.6 1.8 1.9 2.0 2.0 2.1 1.7 2.0 1.8 1.8 1.8 1.9 1.7 2.1 1.7 1.9 1.8 1.9 1.9 1.9 1.9 1.8 2.0 2.1 1.6 1.9 1.9 2.0 2.3 1.9 1.7 1.8 1.9 2.1 1.8 1.6 1.8 1.9 2.0 2.0 2.1 1.7 2.0 1.8 1.8 1.8 1.9 1.7 2.1 1.7 1.9 1.8 1.9 1.9 1.9 1.9 1.8 2.0 2.1 1.6 1.9 Gavage ml Day 26 1.9 2.0 2.3 1.9 1.7 1.8 1-9 2.1 1-8 1.6 1.8 1.9 2.0 2.0 2.1 1.7 2.0 1.8 1.8 1.8 1.9 1.7 2.1 1.7 1.9 1.8 1.9 1.9 1.9 1 -9 1.8 2.0 2.1 1.6 1.9 Gavage ml Day 27 1.9 2.0 2.3 1.9 1.7 1.8 1.9 2.1 1.8 1.6 1.8 1.9 2.0 2.0 2.1 1.7 2.0 1.8 1.8 1.8 1.9 1.7 2.1 1.7 1.9 1.8 1.9 1.9 1.9 1.9 1.8 2.0 2.1 1.6 1.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 2.2 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.1 2.1 2.1 1.9 1.9 1.9 2.0 2.0 2.0 2.1 2.1 2.1 2.3 2.3 2.3 2.1 2.1 2.1 1.8 1.8 1.8 1.9 1.9 1.9 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 1.8 1.8 1.8 2.2 2.2 2.2 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 1.9 1.9 1.9 2.3 2.3 2.3 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1,9 1.9 2.1 2.1 2.1 2.2 2.2 2.2 1.7 1.7 1.7 2.1 2.1 2.1 -510- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 2.2 2.2 2.2 2.2 2.4 2.2 2.2 2.2 2.2 2.4 2.5 2.5 2.5 2.5 2.7 2.1 2.1 2.1 2.1 2.3 1.9 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.2 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.4 2.1 2.1 2.1 2.1 2.2 1.8 1.8 1.8 1.8 1.9 1.9 1.9 1.9 1.9 2.1 2.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.3 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.6 1.8 1.8 1.8 1.8 2.0 2.2 2.2 2.2 2.2 2.3 2.0 2.0 2.0 2.0 2.1 2.0 2.0 2.0 2.0 2.1 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 2.3 1.9 1.9 1.9 1.9 2.0 2.3 2.3 2.3 2.3 2.5 1.9 1.9 1.9 1.9 1.9 2.0 2.0 2 ;0 2.0 2.2 2.0 2.0 2.0 2.0 2.2 2.0 2.0 2.0 2.0 2.2 2.1 2.1 2.1 2.1 2.2 2.0 2.0 2.0 2.0 2.2 2.0 2.0 2.0 2.0 2.2 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 1.7 1.7 1.7 1.7 1.9 2.1 2.1 2.1 2.1 2.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 24 Gavage ml Day 25 Male, V : 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057, 665011 665109 664998 665077 665158 665002 665067 2.1 1.9 2.0 2.0 2.0 1.7 1.9 1.9 2.1 1.9 1.7 1.9 1.8 2.0 1.7 1.9 1.9 1.7 1.7 1.8 1.8 1.9 1.9 1.7 1.9 2.0 2.0 2.0 2.0 1.8 1.9 2.0 2.0 1.7 1.9 1.8 2.0 1.9 2.1 1.9 2.0 2.0 2.0 1.7 1.9 1.9 2.1 1.9 1.7 1.9 1.8 2.0 1.7 1.9 1.9 1.7 1.7 1.8 1.8 1.9 1.9 1.7 1.9 2.0 2.0 2.0 2.0 1.8 1.9 2.0 2.0 1.7 1.9 1.8 2.0 1.9 Gavage ml Day 26 2.1 1.9 2.0 2.0 2.0 1.7 1.9 1.9 2.1 1.9 1.7 1.9 1.8 2.0 1.7 1.9 1.9 1.7 1.7 1.8 1.8 1.9 1.9 1.7 1.9 2.0 2.0 2.0 2.0 1.8 1.9 2.0 2.0 1.7 1.9 1.8 2.0 1.9 Gavage ml, Day 27 2.1 1.9 2.0 2.0 2.0 1.7 1.9 1.9 2.1 1.9 1.7 1.9 1.8 2.0 1.7 1.9 1.9 1.7 1.7 1.8 1.8 1.9 1.9 1.7 1.9 2.0 2.0 2.0 2.0 1.8 1.9 2.0 2.0 1.7 1.9 1.8 2.0 1.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.2 1-9 1.9 1.9 2.1 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.0 2.0 2.0 1.8 1.8 1.8 2.0 2.0 2.0. 1.9 1.9 1.9 2.2 2.2 2.2 1.9 1.9 1.9 2.1 2.1 2.1 2.0 2.0 2.0 1.7 1.7 1.7 1.8 1.8 1.8 1.9 1.9 1-9 2.0 2.0 2.0 2.1 2.1 2.1 2.0 2.0 2.0 1.8 1.8 1.8 2.0 2.0 2.0 2,2 2.2 2.2 2.1 2.1 2.1 2.2 2.2 2.2 2.1 2.1 2.1 1.9 1.9 1.9 2.1 2.1 2.1 2.2 2.2 2.2 2.1 2.1 2.1 1.8 1.8 1.8 2.1 2.1 2.1 1.9 1.9 1.9 2.1 2.1 2.1 2.0 2.0 2.0 -511 - Company Sanitized. Does not contain TSCA CBI DuPont-11418 Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 2.3 2.3 2.3 2.3 2.4 2.1 2.1 2.1 2.1 2.3 2.1 2.2 2.1 2.2 2.1 2.2 2.1 2.2 2.2 2.3 2 . 2 2.2 2.2 2.2 2.3 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.2 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.1 1.8 1.8 1.8 1.8 1.9 2.0 2.0 2.0 2.0 2.3 1.9 1.9 1.9 1.9 2.0 2.2 2.2 2.2 2.2 2.3 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.3 2.0 2.0 2.0 2.0 2.1 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 2.0 1.9 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 2.2 2.0 2.0 2.0 2.0 2.2 1.8 1.8 1.8 1.8 1.9 2.0 2.0 2 ;0 2.0 2.2 2.2 2.2 2.2 2.2 2.3 2.1 2.1 2.1 2.1 2.3 2.2 2 . 2 2.2 2.2 2.4 2.1 2.1 2.1 2.1 2.3 1.9 1.9 1.9 1.9 2.0 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.1 2.1 2.1 2.1 2.2 1.8 1.8 1.8 1.8 2.0 2.1 2.1 2.1 2.1 2.2 1.9 1.9 1.9 1.9 2.1 2.1 2.1 2.1 2.1 2.3 2.0 2.0 2.0 2.0 2.2 c H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 24 Gavage ml Day 25 Gavage ml Day 26 Gavage ml Day 27 Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 Male, VII 1000 mg/kg 665095 1.8 1.8 1.8 1.8 1.9 1.9 1.9 665031 2.0 2.0 2.0 2.0 2.1 2.1 2.1 665146 2.0 2.0 2.0 2.0 2.1 2.1 2.1 665062 2.0 2.0 2.0 2.0 2.1 2.1 2.1 665138 1.7 1.7 1.7 1.7 1.8 1.8 1.8 665112 2.0 2.0 2.0 2.0 2.1 2.1 2.1 665007 2.0 2.0 2.0 2.0 2.2 2.2 2.2 -512- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.9 1.9 1.9 1.9 2.1 2.1 2.1 2.1 2.1 2.3 2.1 2.1 2.1 2.1 2.2 2.1 2.1 2.1 2.1 2.3 1.8 1.8 1.8 1.8 2.0 2.1 2.1 2.1 2.1 2.2 2 . 2 2.2 2 . 2 2.2 2.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 36 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015' 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149' 2.1 2.2 2.7 2.5 2.1 2.4 2.4 2.5 2.1 2.1 2.4 2.3 2.2 2.2 2.4 2.3 2.2 2.1 2.0 2.3 2.4 2.1 2.5 2.0 2.3 2.0 2.2 2.5 2.2 2.0 2.2 2.3 2.1 2.0 2.5 2.0 2.1 2.4 lale Gavage ml Day 37 2.1 2.2 2.7 2.5 2.1 2.4 2.4 2.5 2.1 2.1 2.4 2.3 2.2 2.2 2.4 2.3 2.2 2.1 2.0 2.3 2.4 2.1 2.5 2.0 2.3 2.0 2.2 2.5 2.2 2.0 2.2 2.3 2.1 2.0 2.5 2.0 2.1 2.4 Gavage ml Day 38 2.1 2.2 2.7 2.5 2.1 2.4 2.4 2.5 2.1 2.1 2.4 2.3 2.2 2.2 2.4 2.3 2.2 2.1 2.0 2.3 2.4 2.1 2.5 2.0 2.3 2.0 2.2 2.5 2.2 2.0 2.2 2.3 2.1 2.0 2.5 2.0 2.1 2.4 Gavage ml Day 39 2.1 2.2 2.7 2.5 2.1 2.4 2.4 2.5 2.1 2.1 2.4 2.3 2.2 2.2 2.4 2.3 2.2 2.1 2.0 2.3 2.4 2.1 2.5 2.0 2.3 2.0 2.2 2.5 2.2 2.0 2.2 2.3 2.1 2.0 2.5 2.0 2.1 2.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.1 2.1 2.3 2.2 2.2 2.3 2.7 2.7 2.8 2.5 2.5 2.6 2.1 2.1 2.2 2.4 2.4 2.5 2.4 2.4 2.4 2.5 2.5 2.6 2.1 2.1 2.2 2.1 2.1 2.1 2.4 2.4 2.5 2.3 2.3 2.4 2.2 2.2 2.4 2.2 2.2 2.3 2.4 2.4 2.5 2.3 2.3 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.0 2.0 2.1 2.3 2.3 2.3 2.4 2.4 2.6 2.1 2.1 2.1 2.5 2.5 o fi 2.0 2.0 2.1 2.3 2.3 2.4 2.0 2.0 2.1 2.2 2.2 2.3 2.5 2.5 2.6 2.2 2.2 2.3 2.0 2.0 2.1 2.2 2.2 2.2 2.3 2.3 2.4 2.1 2.1 2.2 2.0 2.0 2.1 2.5 2.5 2.6 2.0 2.0 2.1 2.1 2.1 2.2 2.4 2.4 2.5 -513- Company Sanitized. Does not contain TSCA CBI DuPont-11418 Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.8 2.8 2.8 2.8 2.8 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.3 2.6 22.. 63 2.3 2.6 2.3 2.6 2.3 2.6 2.3 2.3 2.3 2.3 2.3 2 ;1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.5 ( H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study:" Gavage ml Day 36 Male, I 0 mg/kg 665081 665159 665043 665064 665121 665106 665008 2.1 2.3 2.3 2.2 2.2 2.4 2.3 lale Gavage ml Day 37 2.1 2.3 2.3 2.2 2.2 2.4 2.3 Gavage ml Day 38 . 2.1 2.3 2.3 2.2 2.2 2.4 2.3 Gavage ml Day 39 2.1 2.3 2.3 2.2 2.2 2.4 2.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.1 2.1 2.2 2.3 2.3 2.4 2.3 2.3 2.5 2.2 2.2 2.2 2.2 2.2 2.3 2.4 2.4 2.5 2.3 2.3 2.5 -514- ( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: le Gavage ml Day 36 Gavage ml Day 37 Male, III: 10 mg/kg 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156, 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 2.3 2.4 2.4 2.3 2.0 2.1 2.3 2.2 2.4 2.1 1.7 2.2 2.0 2.1 1.9 2.2 2.2 2.1 2.1 2.0 2.0 2.1 2.2 2.0 2.3 2.1 1.9 2.3 2.5 1.9 2.1 2.3 2.2 2.0 2.2 2.3 2.4 2.4 2.3 2.0 2.1 2.3 2.2 2.4 2.1 1.7 2.2 2.0 2.1 1.9 2.2 2.2 2.1 2.1 2.0 2.0 2.1 2.2 2.0 2.3 2.1 1.9 2.3 2.5 1.9 2.1 2.3 2.2 2.0 2.2 Gavage ml Day 38 2.3 2.4 2.4 2.3 2.0 2.1 2.3 2.2 2.4 2.1 1.7 2.2 2.0 2.1 1.9 2.2 2.2 2.1 2.1 2.0 2.0 2.1 2.2 2.0 2.3 2.1 1.9 2.3 2.5 1.9 2.1 2.3 2.2 2.0 2.2 Gavage ml Day 39 2.3 2.4 2.4 2.3 2.0 2.1 2.3 2.2 2.4 2.1 1.7 2.2 2.0 2.1 1.9 2.2 2.2 2.1 2.1 2.0 2.0 2.1 2.2 2.0 2.3 2.1 1.9 2.3 2.5 1.9 2.1 2.3 2.2 2.0 2.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.3 2.3 2.4 2.4 2.4 2.5 2.4 2.4 2.6 2.3 2.3 2.4 2.0 2.0 2.1 2.1 2.1 2.2 2.3 2.3 2.4 2.2 2.2 2.3 2.4 2.4 2.5 2.1 2.1 2.1 1.7 1.7 1.8 2.2 2.2 2,3 2.0 2.0 2.1 2.1 2.1 2.2 1.9 1.9 2.0 2.2 2.2 2.3 2.2 2.2 2.4 2.1 2.1 2.2 2.1 2.1 2.3 2.0 2.0 2.2 2.0 2.0 2.2 2.1 2.1 2.2 2.2 2.2 2 .3 2.0 2.0 2.1 2.3 2.3 2.3 2.1 2.1 2.2 1.9 1.9 2.0 2.3 2.3 2.5 2.5 2.5 2.5 1.9 1.9 2.1 2.1 2.1 2.2 2.3 2.3 2.4 2.2 2.2 2.4 2.0 2.0 2.0 2.2 2.2 2.3 -515- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.4 2.4 2.4 2.4 2.4 2.5 2.6 2.5 2.6 22.. 65 2.5 2.6 2.5 2.6 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.1 2.1 2.1 1.8 1-8 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2 . 2 2.2 2 . 2 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2'.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2 . 0 2.0 2 . 0 2 . 0 2.0 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2 . 0 2.0 2.0 2.0 2.3 2.3 2.3 2.3 2.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 36 Gavage ml Day 37 Gavage ml Day 38 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066' 665039 665003 665088 665147 2.4 2.4 2.7 2.3 2.0 2.2 2.3 2.4 2.2 1.9 2.1 2.2 2.3 2.3 2.6 2.0 2.3 2.1 2.1 2.1 2.3 2.0 2.5 1.9 2.2 2.2 2.2 2.2 2.2 2.2 2.0 2.2 2.4 1.9 2.2 2.4 2.4 2.4 2.4 2.7 2.7 2.3 2.3 2.0 2.0 2.2 2.2 2.3 . 2.3 2.4 2.4 2.2 2.2 1.9 1.9 2.1 2.1 2.2 2.2 2.3 2.3 2.3 2.3 2.6 2.6 2.0 2.0 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.0 2.0 2.5 2.5 1.9 1.9 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.0 2.0 2.2 2.2 2.4 2.4 1.9 1.9 2.2 2.2 Gavage ml Day 39 2.4 2.4 2.7 2.3 2.0 2.2 2.3 2.4 2.2 1.9 2.1 2.2 2.3 2.3 2.6 2.0 2.3 2.1 2.1 2.1 2.3 2.0 2.5 1.9 2.2 2.2 2.2 2.2 2.2 2.2 2.0 2.2 2.4 1.9 2.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.4 2.4 2.5 2.4 2.4 2.4 2.7 2.7 2.8 2.3 2.3 2.4 2.0 2.0 2.1 2.2 2.2 2.2 2.3 2.3 2.3 2.4 2.4 2.5 2.2 2.2 2.3 1.9 1.9 1.9 2.1 2.1 2.2 2.2 2.2 2.2 2.3 2.3 2.5 2.3 2.3 2.4 2.6 2.6 2.8 2.0 2.0 2.1 2.3 2.3 2.4 2.1 2.1 2.2 2.1 2.1 2.2 2.1 2.1 2.1 2.3 2.3 2.4 2.0 2.0 2.1 2.5 2.5 2.6 1.9 1.9 2.1 2.2 2.2 2.3 2.2 2.2 2.3 2.2 2.2 2.3 2.2 2.2 2.3 2.2 2.2 2.3 2.2 2.2 2.3 2.0 2.0 2.1 2.2 2.2 2.4 2.4 2.4 2.5 1.9 1.9 1.9 2.2 2.2 2.3 -516- (( DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.8 2 . 8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.3 2.3 2.3 2.3 2.3 ,1.9 1.9 1.9 1.9 1.9 2 . 2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.8 2.8 2.8 2.8 2 . 8 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2 . 2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2:3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 1.9 1.9 1.9 1.9 1.9 2.3 2.3 2.3 2.3 2.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study : |nale Gavage ml Day 36 Gavage ml Day 37 Male, VII: 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022' 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 2.4 2.3 2.2 2.3 2.3 2.0 2.2 2.2 2.4 2.1 1.9 2.3 2.0 2.3 2.0 2.3 2.1 1.8 2.0 2.0 2.1 2.2 2.2 1.9 2.2 2.3 2.3 2.4 2.3 2.0 2.2 2.4 2.2 2.0 2.2 2.1 2.3 2.2 2.4 2.3 2.2 2.3 2.3 2.0 2.2 2.2 2.4 2.1 1.9 2.3 2.0 2.3 2.0 2.3 2.1 1.8 2.0 2.0 2.1 2.2 2.2 1.9 2.2 2.3 2.3 2.4 2.3 2.0 2.2 2.4 2.2 2.0 2.2 2.1 2.3 2.2 Gavage ml Day 38 2.4 2.3 2.2 2.3 2.3 2.0 2.2 2.2 .2.4 2.1 1.9 2.3 2.0 2.3 2.0 2.3 2.1 1.8 2.0 2.0 2.1 2.2 2.2 1.9 2.2 * 2.3 2.3 2.4 2.3 2.0 2.2 2.4 2.2 2.0 2.2 2.1 2.3 2.2 Gavage ml Day 39 2.4 2.3 2.2 2.3 2.3 2.0 2.2 2.2 2.4 2.1 1.9 2.3 2.0 2.3 2.0 2.3 2.1 1.8 2.0 2.0 2.1 2.2 2.2 1.9 2.2 2.3 2.3 2.4 2.3 2.0 2.2 2.4 2.2 2.0 2.2 2.1 2.3 2.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.4 2-4 2.5 2.3 2.3 2.4 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.4 2.0 2.0 2.0 2.2 2.2 2.3 2.2 2.2 2.3 2.4 2.4 2.5 2.1 2.1 2.2 1.9 1.9 2.0 2.3 2.3 2.4 2.0 2.0 2.1 2.3 2.3 2.4 2.0 2.0 2.1 2.3 2.3 2.4 2.1 2.1 2.2 1.8 1.8 1.9 2.0 2.0 2.1 2.0 2.0 2.2 2.1 2.1 2.2 2.2 2.2 2.3 2.2 2.2 2.3 1.9 1.9 2.0 2.2 2.2 2.3 2.3 2.3 2.4 2.3 2.3 2.4 2.4 2.4 2.5 2.3 2.3 2.4 2.0 2.0 2.1 2.2 2.2 2.4 2.4 2.4 2.5 2.2 2.2 2.4 2.0 2.0 2.1 2.2 2.2 2.3 2.1 2.1 2.2 2.3 2.3 2.5 2.2 2.2 2.3 -517- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 2.0 2.0 2.0 2.0 2.0 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 1.9 1.9 1.9 1.9 1.9 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.0 2.0 2.0 2.0 2.0 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.5 2.3 2.3 2.3 2.3 2.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 36 Gavage ml Day 37 Male, VII 1000 mg/kg 665095 665031 665146 665062 665138, 665112 665007 2.1 2.3 2.2 2.3 2.0 2.2 2.3 2.1 2.3 2.2 2.3 2.0 2.2 2.3 Gavage ml Day 38 2.1 2.3 2.2 2.3 2.0 2.2 2.3 Gavage ml Day 39 2.1 2.3 2.2 2.3 2.0 2.2 2.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 2.1 2.1 2.2 2.3 2.3 ' 2.4 2.2 2.2 2.4 2.3 2.3 2.4 2.0 2.0 2.1 2.2 2.2 2.3 2.3 2.3 2.5 -518- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 2.2 2.2 2.2 2.2 2. 2.4 2.4 2.4 2.4 2. 2.4 2.4 2.4 2.4 2. 2.4 2.4 2.4 2.4 2. 2.1 2.1 2.1 2.1 2. 2.3 2.3 2.3 2.3 2. 2.5 2.5 2.5 2.5 2. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 48 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040. 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 2.3 2.3 2.8 2.6 2.2 2.5 2.4 2.6 2.2 2.1 2.5 2.4 2.4 2.3 2.5 2.5 2.3 2.2 2.1 2.3 2.6 2.1 2.6 2.1 2.4 2.1 2.3 2.6 2.3 2.1 2.2 2.4 2.2 2.1 2.6 2.1 2.2 2.5 lale Gavage ml Day 49 2.4 2.4 2.9 2.7 2.3 2.6 2.5 2.8 2.3 2.2 2.6 2.5 2.5 2.4 2.7 2.6 2.4 2.3 2.2 2.5 2.7 2.3 2.8 2.2 2.5 2.2 2.4 2.8 2.4 2.2 2.3 2.5 2.3 2.2 2.7 2.2 2.2 2.6 Gavage ml Day 50 ' 2.4 2.4 2.9 2.7 2.3 2.6 2.5 2.8 2.3 2.2 2.6 2.5 2.5 2.4 2.7 2.6 2.4 2.3 2.2 2.5 2.7 2.3 2.8 2.2 2.5 2.2 2.4 2.8 2.4 2.2 2.3 , 2.5 2.3 2.2 2.7 2.2 2.2 2.6 Gavage ml Day 51 2.4 2.4 2.9 2.7 2.3 2.6 2.5 2.8 2.3 2.2 2.6 2.5 2.5 2.4 2.7 2.6 2.4 2.3 2.2 2.5 2.7 2.3 2.8 2.2 2.5 2.2 2.4 2.8 2.4 2.2 2.3 2.5 2.3 2.2 2.7 2.2 2.2 2.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 2.4 2.4 2.4 2.4 2.4 2.4 2.9 2.9 2.9 2.7 2.7 2.7 2.3 2.3 2.3 2.6 2.6 2.6 2.5 2.5 2.5 2.8 2.8 2.8 2.3 2.3 2.3 2.2 2.2 2.2 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.7 2.7 2.7 2.6 2.6 2.6 2.4 2.4 2.4 2.3 2.3 2.3 2.2 2.2 2.2 2.5 2.5 2.5 2.7 2.7 2.7 2.3 2.3 2.3 2.8 2.8 2.8 2.2 2.2 2.2 2.5 2.5 2.5 2.2 2.2 2.2 2.4 2.4 2.4 2.8 2.8 2.8 2.4 2.4 2.4 2.2 2.2 2.2 2.3 2.3 2.3 2.5 2.5 2.5 2.3 2.3 2.3 2.2 2.2 2.2 2.7 2.7 2.7 2.2 2.2 2.2 2.2 2.2 2.2 2.6 2.6 2.6 -519- DuPont-11418 C o m p a n y Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.9 3.1 3.1 3.1 3.1 2.7 2.8 2.8 2.8 2.8 2.3 2.4 2.4 2.4 2.4 2.6 2.8 2.8 2.8 2.8 2.5 2.6 2.6 2.6 2.6 2.8 2.9 2.9 2.9 2.9 2.3 2.4 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.3 2.6 2.7 2.7 2.7 2.7 2.5 2.7 2.7 2.7 2.7 2.5 2.6 2.6 2.6 2.6 2.4 2.5 2.5 2.5 2.5 2.7 2.8 2.8 2.8 2.8 2.6 2.7 2.7 2.7 2.7 2.4 2.5 2.5 2.5 2.5 2.3 2.4 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.3 2.5 2.7 2.7 2.7 2.7 2.7 2.9 2.9 2.9 2.9 2.3 2.4 2.4 2.4 2.4 2.8 2.9 2.9 2.9 2.9 2.2 2.3 2.3 2.3 2.3 2.5 2.6 2.6 2.6 2.6 2.2 2.3 2.3 2.3 2.3 2.4 2.5 2.5 2.5 2.5 2.8 2.9 2.9 2.9 2.9 2.4 2.5 2.5 2.5 2.5 2.2 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.5 2.6 2.6 2.6 2.6 2.3 2.4 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.3 2.7 2.9 2.9 2.9 2.9 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.6 2.7 2.7 2.7 2.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 48 Male, I 0 mg/kg 665081 665159 665043 665064 665121 665106 665008 2.2 2.4 2.5 2.2 2.3 2.5 2.5 lale Gavage ml Day 49 2.3 2.5 2.6 2.3 2.4 2.7 2.6 Gavage ml Day 50 2.3 2.5 2.6 2.3 2.4 2.7 2.6 Gavage ml Day 51 2.3 2.5 2.6 2.3 2.4 2.7 2.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 2.3 2.3 2.3 2.5 2.5 2.5 2.6 2.6 2.6 2.3 2.3 2.3 2.4 2.4 2.4 2.7 2.7 2.7 2.6 2.6 2.6 -520- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.3 2.4 2.4 2.4 2.4 2.5 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.3 2.3 2.3 2.3 2.3 2.4 2.5 2.5 2.5 2.5 2.7 2.7 2.7 2.7 2.7 2.6 2.7 2.7 2.7 2.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml ' Day 48 Gavage ml Day 49 Male, III 10 m g / k g 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 . 665032 664997 665110 665041 665058 665113' 665056 665025 665038 665006 665167 665020 2.4 2.5 2.6 2.4 2.1 2.2 2.4 2.3 2.5 2.1 1.8 2.3 2.1 2.2 2.0 2.3 2.4 2.2 2.3 2.2 2.2 2.2 2.3 2.1 2.3 2.2 2.0 2.5 2.5 2.1 2.2 2.4 2.4 2.0 2.3 2.6 2.7 2.8 2.5 2.2 2.3 2.5 2.4 2.7 2.2 1.9 2.5 2.2 2.4 2.2 2.4 2.5 2.3 2.4 2.3 2.2 2.3 2.4 2.2 2.5 2.4 2.1 2.6 2.7 2.1 2.3 2.5 2.5 2.2 2.4 Gavage ml Day 50 2.6 2.7 2.8 2.5 . 2.2 2.3 2.5 2.4 2.7 2.2 1.9 2.5 2.2 2.4 2.2 2.4 2.5 2.3 2.4 2.3 2.2 2.3 2.4 2.2 2.5 2.4 2.1 2.6 2.7 2.1 2.3 2.5 2.5 2.2 2.4 Gavage ml Day 51 2.6 2.7 2.8 2.5 2.2 2.3 2.5 2.4 2.7 2.2 1.9 2.5 2.2 2.4 2.2 2.4 2.5 2.3 2.4 2.3 2.2 2.3 2.4 2.2 2.5 2.4 2.1 2.6 2.7 2.1 2.3 2.5 2.5 2.2 2.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 2.6 2.6 2.6 2.7 2.7 2.7 2.8 2.8 2.8 2.5 2.5 2.5 2.2 2.2 2.2 2.3 2.3 2.3 2.5 2.5 2.5 2.4 2.4 2.4 2.7 2.7 2.7 2.2 2.2 2.2 1.9 1.9 1.9 2.5 2.5 2.5 2.2 2.2 2.2 2.4 2.4 2.4 2.2 2.2 2.2 2.4 2.4 2.4 2.5 2.5 2.5 2.3 2.3 2.3 2.4 2.4 2.4 2.3 2.3 2.3 2.2 2.2 2.2 2.3 2.3 2.3 2.4 2.4 2.4 2.2 2.2 2.2 2.5 2.5 2.5 2.4 2.4 2.4 2.1 2.1 2.1 2.6 2.6 2.6 2.7 2.7 2.7 2.1 2.1 2.1 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.4 2.4 2.4 -521 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.6 2.7 2.7 2.7 2.7 2.7 2.8 2 . 8 2.8 2.8 2.8 2.6 2.6 2.6 2.6 2.5 2.6 2.6 2.6 2.6 2.2 2.2 2 . 2 2.2 2.2 2.3 2.4 2.4 2.4 2.4 2.5 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.4 2.4 2.7 2.8 2 . 8 2.8 2.8 2.2 2.3 2.3 2.3 2.3 1.9 1.9 1.9 1.9 1.9 2.5 2.6 2.6 2.6 2.6 2.2 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.3 2.4 2.5 22.. 65 2.5 2.6 2.5 2.6 2.5 2.6 2.3 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2 . 6 2.3 2.4 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.2 2.5 22 .. 26 22.. 62 2.2 2.6 2.2 2.6 2.4 2.4 2.4 2.4 2.4 2.1 2.2 2 . 2 2.2 2.2 2.6 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.1 2.2 2.2 2.2 2.2 2.3 2.4 2.4 2.4 2.4 2.5 2.6 2.6 2.6 2.6 2.5 2.6 2.6 2.6 2.6 2.2 2.2 2.2 2.2 2.2 2.4 2.6 2.6 2.6 2.6 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study :l .le Gavage ml Day 48 Gavage ml Day 49 Male, V 100 mg/kg 665122 2.5 2.6 665155 2.4 2.5 665073 2.8 2.9 665089 2.4 2.5 665119 2.1 2.2 665137 2.2 2.2 665103 2.3 2.4 665143 2.5 2.6 665054 2.3 2.4 665035 1.9 2.0 665048 2.2 2.2 665030 2.2 2.4 665028 2.5 2.6 665052 2.4 2.5 665150 2.8 2.9 665116 2.1 2.2 665034 2.4 2.6 665051 2.2 2.3 665083 2.2 2.3 665124 2.1 2.2 665078 2.4 2.5 665036 2.1 2.2 665085 2.6 2.7 665092 2.1 2.1 665004 2.3 2.5 665140 2.3 2.4 665114 2.3 2.4 665139 2.3 2.4 665111 2.3 2.4 665055 2.3 2.4 665066 2.1 2.3 665039 2.4 2.5 665003 2.5 2.6 665088 1.9 2.0 665147 2.3 2.4 Gavage ml Day 50 2.6 2.5 2.9 2.5 2.2 2.2 2.4 2.6 2.4 2.0 2.2 2.4 2.6 2.5 2.9 2.2 2.6 2.3 2.3 2.2 2.5 2.2 2.7 2.1 2.5 2.4 2.4 2.4 2.4 2.4 2.3 2.5 2.6 2.0 2.4 Gavage ml Day 51 2.6 2.5 2.9 2.5 2.2 2.2 2.4 2.6 2.4 2.0 2.2 2.4 2.6 2.5 2.9 2.2 2.6 2.3 2.3 2.2 2.5 2.2 2.7 2.1 2.5 2.4 2.4 2.4 2.4 2.4 2.3 2.5 2.6 2.0 2.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 2.6 2'.6 2.6 2.5 2.5 2.5 2.9 2.9 2.9 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.6 2.6 2.6 2.4 2.4 2.4 2.0 2.0 2.0 2.2 2.2 2.2 2.4 2.4 2.4 2.6 2.6 2.6 2.5 2.5 2.5 2.9 2.9 2.9 2.2 2.2 2.2 2.6 2.6 2.6 2.3 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.5 2.5 2.5 2.2 2.2 2.2 2.7 2.7 2.7 2.1 2.1 2.1 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.5 2.5 2.5 2.6 2.6 2.6 2.0 2.0 2.0 2.4 2.4 2.4 -522- (( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.6 2.7 2.7 2.7 2.7 2.5 2.7 2.7 2.7 2.7 2.9 2.5 3.0 2.6 3.0 2.6 3.0 2.6 32.. 60 2.2 2.3 2.3 2.3 2.3 2.2 22.. 64 2.4 2.6 2.7 22.. 64 2.7 2.4 2.6 2.7 2.4 2.6 2.7 2.4 2.5 2.5 2.5 2.5 2.0 2.1 2.1 2.1 2.1 2.2 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.6 2.5 2.7 2.6 22.. 67 22.. 67 2.7 2.6 2.9 3.0 3.0 3.0 3.0 2.2 2.6 2.3 2.6 2.3 2.6 2.3 2.6 22.. 63 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.2 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2 . 2 2.7 2.8 2.8 2 . 8 2 . 8 2.1 2 . 2 2.5 2 . 6 2.2 2.6 2.2 2.6 22 .. 62 2.4 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2 . 6 2.7 2.7 2.7 2.7 2.0 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study p n a l e Gavage ml Day 48 Gavage ml Day 49 Male, VII 1000 mg/kg 665160 2.5 2.6 665096 2.4 2.5 665082 2.3 2.4 665107 2.3 2.5 665152 2.4 2.6 665120 2.0 2.2 664999 2.3 2.5 665026 2.3 2.4 665162 2.5 2.6 665027 2.2 2.3 665084 2.0 2.2 665142 2.4 2.6 665118 2.1 2.2 665108 2.4 2.5 665024 2.1 2.2 665050 2.4 2.6 665134 2.2 2.3 665022 1.9 2.0 665105 2.1 2.2 665102 2.2 2.3 665161 2.2 2.3 665133 2.3 2.5 665157 2.3 2.4 665093 2.0 2.1 665059 2.3 2.3 665123 2.4 2.6 665018 2.4 2.5 665065 2.5 2.7 665063 2.4 2.5 665090 2.1 2.3 665057 2.4 2.6 665011 2.5 2.7 665109 2.4 2.6 664998 2.1 2.2 665077 2.3 2.4 665158 2.2 2.2 665002 2.5 2.6 665067 2.3 2.4 Gavage ml Day 50 2.6 2.5 2.4 2.5 2.6 2.2 2.5 2.4 2.6 2.3 2.2 ' 2.6 2.2 2.5 2.2 2.6 2.3 2.0 2.2 2.3 2.3 2.5 2.4 2.1 2.3 2.6 2.5 2.7 2.5 2.3 2.6 2.7 2.6 2.2 2.4 2.2 2.6 2.4 Gavage ml Day 51 2.6 2.5 2.4 2.5 2.6 2.2 2.5 2.4 2.6 2.3 2.2 2.6 2.2 2.5 2.2 2.6 2.3 2.0 2.2 2.3 2.3 2.5 2.4 2.1 2.3 2.6 2.5 2.7 2.5 2.3 2.6 2.7 2.6 2.2 2.4 2.2 2.6 2.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 2.6 2.6 2.6 2.5 2.5 2.5 2.4 2.4 2.4 2.5 2.5 2.5 2.6 2.6 2.6 2.2 2.2 2.2 2.5 2.5 2.5 2.4 2.4 ' 2.4 2.6 2.6 2.6 2.3 2.3 2.3 2.2 2.2 2.2 2.6 2.6 2.6 2.2 2.2 2.2 2.5 2.5 2.5 2.2 2.2 2.2 2.6 2.6 2.6 2.3 2.3 2.3 2.0 2.0 2.0 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.4 2.4 2.4 2.1 2.1 2.1 2.3 2.3 2.3 2.6 2.6 2.6 2.5 2.5 2.5 2.7 2.7 2.7 2.5 2.5 2.5 2.3 2.3 2.3 2.6 2.6 2.6 2.7 2.7 2.7 2.6 2.6 2.6 2.2 2.2 2.2 2.4 2.4 2.4 2.2 2.2 2.2 2.6 2.6 2.6 2.4 2.4 2.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.6 2.5 2.7 2.6 2.7 2.6 22.. 67 2.7 2.6 2.4 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2 . 6 2 . 6 2.7 2.7 2.7 2.7 2 . 2 2.3 2.3 2.3 2.3 2.5 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.4 2.4 2.6 2.7 2.7 2.7 2.7 2.3 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2.6 2.6 2.6 2.6 2.6 2.2 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.2 2.3 2.3 2.3 2.3 2.6 2.7 2.7 2.7 2.7 2.3 2.0 2.3 2.0 2.3 2.0 2.3 2.0 22.. 03 2.2 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.3 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.4 2.5 2.5 2.5 2.5 2.1 2.2 2.2 2.2 2.2 2.3 2.6 2.5 222... 664 2.4 2.6 2.6 2.4 2.6 2.6 2.4 2.6 2.6 2.7 2.8 2.8 2 . 8 2.8 2.5 2.6 2.6 2 . 6 2.6 2.3 2.3 2.3 2.3 2.3 2.6 2.7 2.7 2.7 2.7 2.7 2.6 2.8 2.6 2.8 2.6 2.8 2.6 22.. 68 2.2 2.2 2.2 2 . 2 2.2 2.4 2.5 2.5 2.5 2.5 2.2 2.3 2.3 2.3 2.3 2.6 2.7 2.7 2.7 2.7 2.4 2.5 2.5 2.5 2.5 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 48 Gavage ml Day 49 Male, VII 1000 mg/kg 665095 2.2 2.2 665031 2.4 2.5 665146 2.4 2.5 665062 2.4 2.6 665138 2.1 2.2 665112 2.3 2.4 665007 2.5 2.6 Gavage ml Day 50 t 2.2 2.5 2.5 2.6 2.2 2.4 2.6 Gavage ml Day 51 2.2 2.5 2.5 2.6 2.2 2.4 2.6 Gavage ml Day 52 2.2 2.5 2.5 2.6 2.2 2.4 2.6 Gavage ml Day 53 2.2 2.5 2.5 2.6 2.2 2.4 2.6 Gavage ml Day 54 2.2 2.5 2.5 2.6 2.2 2.4 2.6 -524- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 55 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 2.2 2.3 2.3 2.3 2.3 2.5 2.6 2.6 2.6 2.6 2.5 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.6 2.7 2.7 2.7 2.7 H-25425: Subchronic Toxicity * 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 60 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 2.4 2.5 3.1 2.8 2.4 2.8 2.6 2.9 2.4 2.3 2.7 2.7 2.6 2.5 2.8 2.7 2.5 2.4 2.3 2.7 2.9 2.4 2.9 2.3 2.6 2.3 2.5 2.9 2.5 2.3 2.4 2.6 2.4 2.3 2.9 2.2 2.3 2.7 lale Gavage ml Day 61 2.4 2.5 3.1 2.8 2.4 2.8 2.6 2.9 2.4 2.3 2.7 2.7 2.6 2.5 2.8 2.7 2.5 2.4 2.3 2.7 2.9 2.4 2.9 2.3 2.6 2.3 2.5 2.9 2.5 2.3 2.4 2.6 2.4 2.3 2.9 2.2 2.3 2.7 Gavage ml Day 62 2.4 2.5 3.1 2.8 2.4 2.8 2.6 2.9 2.4 2.3 2.7 2.7 2.6 2.5 2.8 2.7 2.5 ' 2.4 2.3 2.7 2.9 2.4 2.9 2.3 2.6 2.3 2.5 2.9 2.5 2.3 2.4 2.6 2.4 2.3 2.9 2.2 2.3 2.7 Gavage ml Day 63 2.5 2.6 3.3 2.9 2.5 3.0 2.7 3.0 2.6 2.4 2.8 2.8 2.7 2.6 2.9 2.8 2.7 2.5 2.3 2.7 3.0 2.4 3.0 2.3 2.7 2.4 2.6 2.9 2.6 2.3 2.5 2.6 2.4 2.3 3.0 2.3 2.4 2.8 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 2.5 2.5 2.5 2.6 2.6 2.6 3.3 3.3 3.3 2.9 2.9 2.9 2.5 2.5 2.5 3.0 3.0 3.0 2.7 2.7 2.7 3.0 3.0 3.0 2.6 2.6 2.6 2.4 2.4 2.4 2.8 2.8 2.8 2.8 2.8 2.8 2.7 2.7 2.7 2.6 2.6 2.6 2.9 2.9 2.9 2.8 2.8 2.8 2.7 2.7 2.7 2.5 2.5 2.5 2.3 2.3 2.3 2.7 2.7 2.7 3.0 3.0 3.0 2.4 2.4 2.4 3.0 3.0 3.0 2.3 2.3 2.3 2.7 2.7 2.7 2.4 2.4 2.4 2.6 2.6 2.6 2.9 2.9 2.9 2.6 2.6 2.6 2.3 2.3 2.3 2.5 2.5 2.5 2.6 2.6 2.6 2.4 2.4 2.4 2.3 2.3 2.3 3.0 3.0 3.0 2.3 2.3 2.3 2.4 2.4 2.4 2.8 2.8 2.8 -525- (( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 2.5 2.5 2.5 2.6 2.6 2.6 2 . 6 2 . 6 2.7 2.7 3.3 3.3 3.3 3.3 3.3 2.9 2.9 2.9 3.0 3.0 2.5 2.5 2.5 2.6 2 . 6 3.0 3.0 3.0 3.1 3.1 2.7 2.7 2.7 2.8 2.8 3.0 3.0 3.0 3.1 3.1 2.6 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.5 2.5 2.8 2.8 2 . 8 2.9 2.9 2.8 2.8 2 . 8 2.8 2.8 2.7 2.6 22.. 67 2.7 2.6 2.8 2.6 2.8 2.6 2.9 2.9 2.9 2.9 2.9 2.8 2 . 8 2 . 8 2.9 2.9 2.7 2.5 2.7 2.5 2.7 2.5 2.7 2.6 22.. 67 2.3 2.7 2.3 2.7 2.3 2.7 22.. 84 2.4 2.8 3.0 3.0 3.0 3.1 3.1 2.4 2.4 2.4 2.5 2.5 3.0 3.0 3.0 3.1 3.1 2.3 2.3 2.3 2.4 2.4 2.7 2.7 2.7 2.8 2 . 8 2.4 2.6 22.. 64 2.4 2.6 2.5 2.7 2.5 2.7 2.9 2.6 2.9 2.6 22.. 69 3.0 2.6 32.. 60 2.3 2.3 2.3 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2 . 6 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.3 2.3 2.3 2.5 2.5 3.0 3.0 3.0 3.1 3.1 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.8 2.8 2 . 8 2.9 2.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 60 Male, I 0 mg/kg 665081 665159 665043 665064 665121 665106 665008 2.4 2.6 2.7 2.3 2.5 2.7 2.7 Gavage ml Day 61 2.4 2.6 2.7 2.3 2.5 2.7 2.7 Gavage ml Day 62 2.4 2.6 2.7 2.3 ' 2.5 2.7 2.7 Gavage ml Day 63 2.4 2.7 2.7 2.4 2.6 2.8 2.8 Gavage ml Day 64 2.4 2.7 2.7 2.4 2.6 2.8 2.8 Gavage ml Day 65 2.4 2.7 2.7 2.4 2.6 2.8 2.8 Gavage ml Day 66 2.4 2.7 2.7 2.4 2.6 2.8 2.8 -526- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 2.4 2.4 2.4 2.5 2.5 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2 . 8 22.. 64 22.. 64 2.4 2.6 2.4 2.7 2.4 2.7 2 . 8 2.8 2 . 8 2.9 2.9 2 . 8 2.8 2 . 8 2.9 2.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 60 Gavage ml Day 61 Male, til 10 mg/kg 665053 2.7 2.7 665074 2.8 2.8 665128 2.6 2.6 665080 2.6 2.6 664993 2.2 2.2 6.65131 2.4 2.4 665060 2.6 2.6 664995 2.4 2.4 665136 2.8 2.8 665033 2.3 2.3 665132 1.9 1.9 665156 2.6 2.6 665061 2.3 2.3 665145 2.4 2.4 665019, 2.3 2.3 665153 2.5 2.5 665037 2.6 2.6 665163 2.4 2.4 665001 2.6 2.6 665126 2.4 2.4 665125 2.3 2.3 665017 2.4 2.4 665071 2.5 2.5 665032 2.2 2.2 664997 2.6 2.6 665110 2.4 2.4 665041 2.2 2.2 665058 2.7 2.7 665113 2.8 2.8 665056 2.2 2.2 665025 2.4 2.4 665038 2.6 2.6 665006 2.6 2.6 665167 2.2 2.2 665020 2.6 2.6 Gavage ml Day 62 2.7 2.8 2.6 2.6 2.2 2.4 2.6 2.4 2.8 2.3 1.9 2.6 2.3 2.4 2.3 2.5 2.6 2.4 2.6 2.4 2.3 2.4 , 2.5 2.2 2.6 2.4 2.2 2.7 2.8 2.2 2.4 2.6 2.6 2.2 2.6 Gavage ml Day 63 2.8 2.9 3.0 2.7 2.3 2.5 2.7 2.5 2.8 2.4 2.0 2.7 2.3 2.5 2.4 2.5 2.7 2.5 2.7 2.5 2.4 2.4 2.6 2.3 2.6 2.5 2.3 2.8 2.9 2.3 2.5 2.7 2.7 2.3 2.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 2.8 2.8 2.8 2.9 2.9 2.9 3.0 3.0 3.0 2.7 2.7 2.7 2.3 2.3 2.3 2.5 2.5 2.5 2.7 2.7 2.7 2.5 2.5 2.5 2.8 2.8 2.8 2.4 2.4 2.4 2.0 2.0 2.0 2.7 2.7 2.7 2.3 2.3 2.3 2.5 2.5 2.5 2.4 2.4 2.4 2.5 2.5 2.5 2.7 2.7 2.7 2.5 2.5 2.5 2.7 2.7 2,.7 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.3 2.3 2.3 2.6 2.6 2.6 2.5 2.5 2.5 2.3 2.3 2.3 2.8 2.8 2.8 2.9 2.9 2.9 2.3 2.3 2.3 2.5 2.5 2.5 2.7 2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.3 2.6 2.6 2.6 -527- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 2 . 8 2 . 8 2.8 2.9 2.9 2.9 2.9 2.9 3.0 3.0 3.0 3.0 3.0 3.1 3.1 2.7 2.7 2.7 2 . 8 2.8 2.3 2.3 2.3 2.4 2.4 2.5 2.5 2.5 2.6 2.6 2.7 2.7 2.7 2.8 2 . 8 2.5 2.5 2.5 2.5 2.5 2 . 8 2.8 2.8 2.9 2.9 2.4 2.4 2.4 2.5 2.5 2.0 2.0 2.0 2.0 2.0 2.7 2.7 2.7 2.8 2 . 8 2.3 2.5 2.3 2.5 2.3 2.5 22.. 64 2.4 2.6 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2 . 6 2 . 6 2.7 2.7 2.7 2 .8 2 . 8 2.5 2.5 2.5 2.6 2 . 6 2.7 2.5 2.7 2.5 2.7 2.5 2.7 2.6 22.. 67 2.4 2.4 2.4 2.5 2.5 2.4 2.6 22.. 64 2.4 2.6 22.. 65 2.5 2.6 2.3 2.6 2.3 2.6 22.. 63 2.4 2.7 2.4 2.7 2.5 2.5 2.5 2.6 2.6 2.3 2.3 2.3 2.3 2.3 2 .8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 3.0 3.0 2.3 2.3 2.3 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.3 2.6 2.3 2.6 22.. 63 2.4 2.7 2.4 2.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 60 Gavage ml Day 61 Male, V 1 00 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 2.7 2.7 2.7 2.7 3.0 3.0 2.6 2.6 2.3 2.3 2.4 . 2.4 2.6 2.7 2.6 2.7 2.5 2.5 2.1 2.4 2.1 2.4 2.5 2.5 2.7 2.7 2.6 2.6 3.0 3.0 2.3 2.3 2.6 2.6 2.3 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.2 2.2 2.8 2.8 2.2 2.2 2.6 2.6 2.5 2.5 2.4 2.4 2.5 2.5 2.4 2.4 2.4 2.4 2.3 2.3 2.5 2.5 2.7 2.7 2.1 2.1 2.4 2.4 Gavage ml Day 62 2.7 2.7 3.0 2.6 2.3 2.4 2.6 2.7 2.5 , 2.1 2.4 2.5 2.7 2.6 3.0 2.3 2.6 2.3 2.3 2.3 2.5 2.2 2.8 2.2 2.6 2.5 2.4 2.5 2.4 2.4 2.3 2.5 2.7 2.1 2.4 Gavage ml Day 63 2.8 2.7 3.1 2.8 2.4 2.5 2.7 2.8 2.6 2.1 2.5 2.6 2.8 2.7 3.2 2.4 2.7 2.4 2.4 2.4 2.6 2.1 2.9 2.2 2.7 2.6 2.5 2.6 2.5 2.5 2.4 2.6 2.8 2.2 2.5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 2.8 2.8 . 2.8 2.7 2.7 2.7 3.1 3.1 3.1 2.8 2.8 2.8 2.4 2.4 2.4 2.5 2.5 2.5 2.7 2.7 .2.7 2.8 2.8 2.8 2.6 2.6 2.6 2.1 2.1 2.1 2.5 2.5 2.5 2.6 2.6 2.6 2.8 2.8 2.8 2.7 2.7 2.7 3.2 3.2 3.2 2.4 2.4 2.4 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.1 2.1 2.1 2.9 2.9 2.9 2.2 2.7 2.2 2.7 2.2 2.7 2.6 2.5 2.6 2.5 2.6 2.5 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.6 2.6 2.6 2.8 2.8 2.8 2.2 2.2 2.2 2.5 2.5 2.5 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 2.8 2.8 2 . 8 2.9 2.9 2.7 2.7 2.7 2 . 8 2 . 8 3.1 3.1 3.1 3.2 3.2 2.8 2.8 2.8 2.9 2.9 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.6 2 . 6 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2 . 8 2.9 2.9 2.6 2.6 2.6 2.7 2.7 2.1 2.1 2.1 2 . 2 2 . 2 2.5 2.6 2.8 2.5 22.. 86 2.5 2.6 2.8 22.. 65 2.9 2.5 2.6 2.9 2.7 2.7 2.7 2 . 8 2 . 8 3.2 3.2 3.2 3.3 3.3 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.7 2 . 8 2 . 8 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.6 2.6 2.6 2.7 2.7 2.1 2.1 2.1 2.3 2.3 2.9 2.9 2.9 3.0 3.0 2.2 2.2 2 . 2 2.3 2.3 2.7 2.7 2.7 2 . 8 2.8 2.6 2 . 6 2.6 2.7 2.7 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.7 2.7 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.8 2 . 8 2.8 2.2 2.5 2.2 2.5 2.2 2.5 22.. 63 2.3 2.6 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study :| tale Gavage ml Day 60 Gavage ml Day 61 Male, VII 1 0 0 0 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161. 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 2.7 2.6 2.5 2.6 2.7 2.3 2.6 2.4 2.7 2.4 2.2 2.6 2.3 2.5 2.3 2.7 2.3 2.0 2.3 2.4 2.4 2.5 2.5 2.2 2.4 2.6 2.6 2.8 2.6 2.3 2.7 2.8 2.6 2.2 2.5 2.3 2.7 2.5 2.7 2.6 2.5 2.6 2.7 2.3 2.6 2.4 2.7 2.4 2.2 2.6 2.3 2.5 2.3 2.7 2.3 2.0 2.3 2.4 2.4 2.5 2.5 2.2 2.4 2.6 2.6 2.8 2.6 2.3 2.7 2.8 2.6 2.2 2.5 2.3 2.7 2.5 Gavage ml Day 62 2.7 2.6 2.5 2.6 2.7 2.3 2.6 2.4 2.7 2.4 2.2 2.6 2 .3 2.5 2.3 2.7 2.3 2.0 2.3 2.4 2.4 2.5 2.5 2.2 2.4 2.6 2.6 2.8 , 2.6 2.3 2.7 2.8 2.6 2.2 2.5 2.3 2.7 2.5 Gavage ml Day 63 2.7 2.7 2.6 2.8 2.8 2.3 2.7 2.5 2.8 2.5 2.2 2.7 2.4 2.5 2.3 2.8 2.4 2.1 2.4 2.4 2.5 2.6 2.6 2.2 2.4 2.7 2.7 2.8 2.7 2.4 2.8 2.8 2.7 2.3 2.6 2.3 2.8 2.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 2.7 2.7 2.6 2.8 2.8 2.3 2.7 2.5 2.8 2.5 2.2 2.7 2.4 2.5 2.3 2.8 2.4 2.1 2.4 2.4 2.5 2.6 2.6 2.2 2.4 2.7 2.7 2.8 2.7 2.4 2.8 2.8 2.7 2.3 2.6 2.3 2.8 2.6 2.7 2.7 2.6 2.8 2.8 2.3 2.7 2.5 2.8 2.5 2.2 2.7 2.4 2.5 2.3 2.8 2.4 2.1 2.4 2.4 2.5 2.6 2.6 2.2 2.4 2.7 2.7 2.8 2.7 2.4 2.8 2.8 2.7 2.3 2.6 2.3 2.8 2.6 2.7 2.7 2.6 2.8 2.8 2.3 2.7 2.5 2.8 2.5 2.2 2.7 2.4 2.5 2.3 2.8 2.4 2.1 2.4 2.4 2.5 2.6 2.6 2.2 2.4 2.7 2.7 2.8 2.7 2.4 2.8 2.8 2.7 2.3 2.6 2.3 2.8 2.6 -529- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 2.7 2.7 2.7 2 . 8 2 . 8 2.7 2.6 2.7 2.6 2.7 2.6 2.8 2.6 2.8 2.6 2.8 2.8 2.8 2 . 8 2 . 8 2.8 2.8 2.8 2.9 2.9 2.3 2.3 2.3 2.4 2.4 2.7 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2 . 6 2 . 6 2.8 2.8 2.8 3.0 3.0 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.3 2.3 2.7 2.7 2.7 2 . 8 2 . 8 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2 . 6 2 . 6 2.3 2.3 2.3 2.4 2.4 2.8 2.8 2 . 8 2.9 2.9 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.4 2.5 2.4 2.5 2.5 2.6 22.. 65 2.6 2.6 2.6 2.7 2.7 2.6 2.6 2.6 2.5 2.5 2 . 2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.5 2.5 2.7 2.7 2.7 2 . 8 2 . 8 2.7 2.8 2.7 2.8 2.7 2.8 2.8 2.9 2.8 2.9 2.7 2.7 2.7 2 . 8 2 . 8 2.4 2.8 2.8 2.4 2.8 2.8 2.4 2.8 2.8 2.5 2.9 2.9 2.5 2.9 2.9 2.7 2.7 2.7 2 . 8 2 . 8 22.. 63 2.3 2.6 2.3 2.6 2.4 2.6 2.4 2.6 2.3 2.8 22.. 83 2.3 2.8 2.3 2.9 2.3 2.9 2.6 2 . 6 2 . 6 2 . 6 2.6 H-25425: SubchronicToxicity H ^ y G ^ g e Study in Rats with One-Generation ReprorfnrtiTM p.... - ^ r - Dupont Haskell Laboratory Study: ale Gavage Day 60 Gavage ml Day 6l Male, vii 1 0 0 0 mg/kg 665095 665031 665146 665062 665138 665112 665007 2A 1 2 *,,6 2 -6 2.7 2 -2 2.4^ 2 -7 n2.3- 2 . 6c 2.6 2 .7 2.2 2o.42.7 Gavage ml Day 62 2.3 2.6 2.6 2.7 2.2 2.4 2.7 Gavage ml Day 63 2.3 2.6 2.7 2.8 2.3 2.5 2.8 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 2 .3 2.6 2.7 2.8 2 .3 2.5 2.8 2 .3 2.6 2.7 2.8 2.3 2.5 2.8 2.3 2.6 2.7 2.8 2.3 2.5 2.8 -530- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavacp ml Day 71 2.3 2.6 22.. 63 2.3 2.6 2.4 2.7 2.4 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2 . 6 2 .6 2.8 2.8 2 .8 2,9 2.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Gavage ml Day 72 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 2.6 2.7 3.3 3.0 2.6 3.1 2.8 3.1 2.6 2.5 2.9 2.8 2.8 2.6 2.9 2.9 2.7 2.6 2.4 2.8 3.1 2.5 3.1 2.4 2.8 2.5 2.7 3.0 2.6 2.4 2.5 2.7 2.5 -2.5 3.1 2.3 2.4 2.9 lale Gavage ml Day 73 2.6 2.7 3.3 3.0 2.6 3.1 2.8 3.1 2.6 2.5 2.9 2.8 2.8 2.6 2.9 2.3 2.4 2.9 Gavage ml Day 74 2.6 2.7 . 3 -3 3.0 2.6 3.1 2.8 3.1 2.6 2.5 2.9 2.8 2.8 2.6 2.9 2.3 2.4 2.9 Gavage ml Day 75 2.6 2.7 3.3 3.0 2.6 3.1 2.8 3.1 2.6 2.5 2.9 2.8 2.8 2.6 2.9 2.3 2.4 2.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 75 Gavage ml Day 77 Gavage ml Day 78 2 . 6 2.7 2.7 2.7 2 . 8 2 . 8 3.3 3.4 3.4 3.0 3.1 3.1 2.6 2.6 2.6 3.1 3.1 3.1 2 . 8 2.9 2.9 3.1 3.2 3.2 2 . 6 2.7 2.7 2.5 2.5 2.5 2.9 3.0 3.0 2 . 8 2.9 2.9 2.8 2.7 2.7 2 . 6 2.7 2.7 2.9 3.0 3.0 2.3 2.3 2.3 2.4 2.5 2.5 2.9 2.9 2.9 -531 - Company Sanitized. Does not contain TSCA CBI DuPont-11418 Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 3.4 3.4 3.4 3.4 3.4 3.1 3.1 3.1 3.1 3.1 2.6 3.1 2.6 3.1 2.6 3.1 2.6 3.1 2.6 3.1 2.9 2.9 2.9 2.9 2.9 3.2 3.2 3.2 3.2 3.2 2.7 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2.5 2.5 3.0 3.0 3.0 3.0 3.0 2.9 2.9 2.9 2.9 2.9 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 2.3 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.5 2.9 2.9 2.9 2.9 2.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory tr mI Study-.] [naie Gavage ml Day 72 Gavage ml Day 73 Male, 3[ 0 mg/kg 665081 2.5 2.5 665159 2.7 2.7 665043 2 . 8 2 . 8 665064 2.4 2.4 665121 2.7 2.7 665106 2.9 2.9 665008 2.9 2.9 Gavage ml Day 74 2.5 2.7 2.8 2.4 2.7 2.9 2.9 Gavage ml Day 75 2.5 2.7 2.8 2.4 2.7 2.9 2.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 2.5 2.5 2.5 2.7 2 . 8 2 . 8 2 . 8 2.9 2.9 2.4 2.4 2.4 2.7 2 . 8 2 . 8 2.9 3.0 3.0 2.9 3.0 3.0 -532- (( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 2.5 2.5 2.5 2.5 2.5 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.4 2.4 2.4 2.4 2.4 2.8 2.8 2.8 2.8 2.8 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 72 Gavage ml Day 73 Male, III 10 mg/kg 665053 2.9 2.9 665074 3.0 3.0 665128 3.1 3.1 665080 2 . 8 2 . 8 664993 2.4 2.4 665131 2 . 6 2 . 6 665060 2 . 8 2 . 8 664995 2.5 2.5 665136 2.9 2.9 665033 2.5 2.5 665132 2 . 0 2 . 0 665156 2 . 8 2 . 8 665061 2.4 2.4 665145 2 . 6 2 . 6 665019 2.5 2.5 665153 2.6 665037 2.8 665163 2.6 665001 2.7 665126 2.6 665125 2.5 665017 2.5 665071 2.6 665032 2.4 664997 2.7 665110 2.6 665041 2.3 665058 2.9 665113 3.0 665056 2.4 665025 2.5 665038 2.7 665006 2.8 665167, 2.4 665020 2.7 Gavage ml Day 74 2.9 3.0 3.1 2.8 2.4 2.6 2.8 2.5 2.9 . 2.5 2.0 2.8 2.4 2.6 2.5 Gavage ml Day 75 2.9 3.0 3.1 2.8 2.4 2.6 2.8 2.5 2.9 2.5 2.0 2.8 2.4 2.6 2.5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 2.9 3.0 3.0 3.0 3.0 1 3.0 3.1 3.2 3.2 2 . 8 2.5 2.5 2.4 2.5 2.5 2.6 2.6 2.6 2 . 8 2.9 2.9 2.5 2.6 : 2.6 2.9 3.0 3.0 2.5 2 . 6 2.6 2.0 2.0 2.0 2.8 2.8 2.8 2.4 2.5 2.5 2.6 2.6 2.6 2.5 2.7 2.7 -533- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.9 2.9 2.9 2.9 2.9 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3.0 3.0 2.6 2.6 2.6 2.6 2.6 2.0 2.0 2.0 2.0 2.0 2.8 2.8 2.8 2.8 2.8 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study:] rale Gavage ml Day 72 Gavage ml Day 73 Male, V 1 0 0 mg/kg 665122 2.9 2.9 665155 2 . 8 2.8 665073 3.2 3.2 665089 2.9 2.9 665119 2.4 2.4 665137 2 . 6 2 . 6 665103 2.7 2.7 665143 2.9 2.9 665054 2.7 2.7 665035 2 . 2 2.2 665048 2.5 2.5 665030 2 . 6 2 . 6 665028 2.9 2.9 665052 2 . 8 2 . 8 665150 3.3 3.3 665116 2.4 665034 2.8 665051 2.4 665083 2.4 665124 2.1 665078 2.7 665036 2.3 665085 3.0 665092 2.3 665004 2.8 665140 2.7 665114 2.5 665139 2.7 665111 2.5 665055 2.5 665066 2.5 665039 2.6 665003 2.8 665088 2.3 665147 2.6 Gavage ml D^y 74 2.9 2.8 3.2 2.9 2.4 2.6 2.7 2.9 2.7 2.2 2.5 2.6 2.9 2.8 3.3 Gavage ml Day 75 2.9 2.8 3.2 2.9 2.4 2.6 2.7 2.9 2.7 2.2 2.5 2.6 2.9 2.8 3.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 2.9 2.9 2.9 2 . 8 2.9 2.9 3.2 3.2 3.2 2.9 2.9 2.9 2.4 2.5 2.5 2 . 6 2.5 2.5 2.7 2.8 2 . 8 2.9 2.9 , 2.9 2.7 2 . 8 2 . 8 2.2 2.2 2.2 2.5 2 . 6 2 . 6 2 . 6 2.7 2.7 2.9 3.0 3.0 2.8 2.8 2.8 3.3 3.4 3.4 -534- DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 3.2 3.2 3.2 3.2 3.2 2.9 2.9 2.9 2.9 2.9 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2 . 8 2.8 2.8 2 . 8 2 . 8 2.9 2.9 2.9 2.9 2.9 2 . 8 2 . 8 2.8 2 . 8 2.8 2 . 62 .2 2 . 2 2 . 2 2.2 2 .2 2 . 6 2.6 2 . 6 2 . 6 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 2 . 8 2.8 2.8 2 . 8 2.8 3.4 3.4 3.4 3.4 3.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 72 Gavage ml Day 73 Male, VII: 1 0 0 0 mg/kg 665160 2 . 8 2 . 8 665096 2 . 8 2 . 8 665082 2 . 6 2 . 6 665107 2 . 8 2 . 8 665152 2.9 2.9 665120 2.4 2.4 664999 2.7 2.7 665026. 2.6 2.6 665162 3.0 3.0 665027 2.5 2.5 665084 2.3 2.3 665142 2 . 8 2 . 8 665118 2.5 2.5 665108 2 . 6 2 . 6 665024 2.4 2.4 665050 2.9 665134 2.4 665022 2.1 665105 2.4 665102 2.5 665161 2.6 665133 2.7 665157 2.5 665093 2.2 665059 2.5 665123 2.8 665018 2.8 665065 2.9 665063 2.8 665090 2.5 665057 2.9 665011 2.9 665109 2.8 664998 2.4 665077 2.6 665158 2.3 2.3 665002 2.9 2.9 665067 2.6 2 . 6 Gavage ml Day 74 2.8 2.8 2.6 2.8 2.9 2.4 2.7 2.6 3.0 2.5 2.3 2.8 2.5 2.6 2.4 2.3 2.9 2.6 Gavage ml Day 75 2.8 2.8 2.6 2.8 2.9 2.4 2.7 2.6 3.0 2.5 2.3 2.8 2.5 2.6 2.4 2.3 2.9 2.6 Gavage ml Day 76 2.8 2.8 2.6 2.8 2.9 2.4 2.7 2.6 3.0 2.5 2.3 2.8 2.5 2.6 2.4 2.3 2.9 2.6 Gavage ml Day 77 2.9 2.8 2.6 2.8 2.9 2.4 2.8 2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2.4 2.9 2.7 Gavage ml Day 78 2.9 2.8 2.6 2.8 2.9 2.4 2.8 -2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2.4 2.9 2.7 Company Sanitized. Does not contain TSCA CBI DuPont-11418 Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 2.9 2.8 2.6 2.8 2.9 2.4 2.8 2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2.9 2.8 2.6 2.8 2.9 2.4 2.8 2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2.9 2.8 2.6 2.8 2.9 2.4 2.8 2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2.9 2.8 2.6 2.8 2.9 2.4 2.8 2.6 3.0 2.6 2.4 2.8 2.5 2.6 2.4 2 .! 2.1 2.1 2.1 2 '.! 2 .. 2.1 2.1 3.1 2 .i 2. 2. 2 .! 2 .i 2 . 2.4 2.4 2.4 2.4 2 . 2.9 2.9 2.9 2.9 2 . 2.7 2.7 2.7 2.7 2 . H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study ale INDIVIDUAL DOSE VOLUMES Gavage ml Day 72 Gavage ml Day 73 Gavage ml Day 74 Gavage ml Day 75 Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 Male, VII 1000 mg/kg 665095 665031 665146 665062 665138 665112 665007 2.4 2.7 2.8 2.8 2.3 2.6 2.9 2.4 2.7 2.8 2.8 2.3 2.6 2.9 2.4 2.7 , 2.8 2.8 2.3 2.6 2.9 2.4 2.7 2.8 2.8 2.3 2.6 2.9 2.4 2.7 2.8 2.8 2.3 2.6 2.9 2.5 2.8 2.8 2.9 2.4 2.6 3.0 2.5 2.8 2.8 2.9 2.4 2.6 3.0 -536- DuPont-11418 Company Sanitized. Does not contain TSCA CBi Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 2.5 2.8 2.8 2.9 2.4 2.6 3.0 2.5 2.8 2.8 2.9 2.4 2.6 3.0 2.5 2.8 2.8 2.9 2.4 2.6 3.0 2.5 2.8 2.8 2.9 2.4 2.6 3.0 . 2.5 2.8 2.8 2.9 2.4 2.6 3.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale INDIVIDUAL DOSE VOLUMES Gavage ml Day 84 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 85 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 86 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 87 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 88 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 89 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 90 2.7 2.8 3.5 3.1 2.6 3.2 3.0 3.2 2.8 2.5 3.0 3.0 2.8 2.7 3.1 2.4 2.5 3.0 Gavage ml Day 91 2.8 2.8 3.6 3.1 2.7 3.3 3.0 3.3 2.8 2.6 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 84 Male, I 0 mg/kg 665081' 665159 665043 665064 665121 665106 665008 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 85 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 86 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 87 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 88 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 89 2.5 2.8 3.0 2.5 2.8 3.1 3.0 Gavage ml Day 90 2.5 2.8 3.0 2.5 2.8 3.1 3.0 -538- Gavage ml Day 91 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: lale Gavage ml Day 84 Gavage ml Day 85 Male, III 10 mg/kg 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126, 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 3.0 3.1 3.3 2.7 2.5 2.6 3.0 2.6 3.0 2.6 2.1 2.9 2.5 2.6 2.6 3.0 3.1 3.3 2.7 2.5 2.6 3.0 2.6 3.0 2.6 2.1 2.9 2.5 2.6 2.6 Gavage ml Day 86 3.0 3.1 3.3 2.7 2.5 2.6 3.0 2.6 3.0 2.6 2.1 2.9 2.5 2.6 2.6 Gavage ml Day 87 3.0 3.1 3.3 2.7 2.5 2.6 3.0 2.6 3.0 2.6 2.1 2.9 2.5 2.6 2.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 3.0 3.0 3.0 3.1 3.1 3.1 3.3 3.3 3.3 2.7 2.7 2 .7 2.5 2 .5 2 .5 2.6 2.6 2 .6 3.0 3.0 3.0 2. 6 2 .6 2 .6 3.0 3.0 3.0 2 . 6 2 .6 2 .6 2.1 2.1 2 .1 2.9 2 .9 2 .9 2.5 2 .5 2 .5 2 . 6 2 .6 2 .6 2 . 6 2 .6 2 .6 ( -539- Gavage ml Day 91 3.1 3.2 3.2 22.. 68 2.6 3.0 2.7 3.0 2.7 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study:' tale Gavage ml Day 84 Gavage ml Day 85 Male, V 100 mg/kg 6.65122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 3.0 3 .0 3.2 3.0 2.5 2 .6 2.9 3.0 2 .8 2.2 2.6 2.7 3 .0 2 .9 3.4 3.0 3.0 3.2 '3.0 2.5 2.6 2.9 3.0 2.8 2.2 2.6 2.7 3.0 2.9 3.4 Gavage ml Day 86 Gavage ml Day 87 3.0 3.0 3.2 3.0 2.5 2.6 2.9 3.0 2.8 2.2 2.6 2.7 3.0 2.9 , 3.4 3.0 3.0 3.2 3.0 2.5 2.6 2.9 3.0 2.8 2.2 2.6 2.7 3.0 2.9 3.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.0 3.0 3 .0 2.5 2.5 2.5 2.6 2.6 2.6 2.9 2.9 2.9 3.0 3.0 3.0 2.8 2.8 2 .8 2.2 2.2 2.2 2.6 2.7 2.6 2.7 2.6 2.7 3.0 3.0 3.0 2.9 2.9 2.9 3.4 3.4 3.4 -540- Gavage ml Day 91 3.0 3.0 3.3 2.9 2.6 2.6 2.9 3.0 2.9 2.3 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: (ale Gavage ml Day 84 Gavage ml Day 85 Gavage ml Day 86 Male, VII 1000 mg/kg 665160 2.9 2.9 2.9 665096 2.9 2.9 . 2.9 665082 2.7 2.7 2.7 665107 2.9 2.9 2.9 665152 3.0 3.0 3.0 665120 2.5 2.5 2.5 664999 2 . 8 2 . 8 2 . 8 665026 2.7 2.7 2.7 665162 3.1 3.1 3.1 665027 2.7 2.7 2.7 665084 2.5 2.5 2.5 665142 2.9 2.9 2.9 665118 2.5 2.5 2.5 '665108 2.7 2.7 2.7 665024 2.5 2.5 2.5 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 2.4 2.4 2.4 665002 3.0 3.0 3.0 665067 2.7 2.7 2.7 Gavage ml Day 87 2.9 2.9 2.7 2.9 3.0 2.5 2.8 2.7 3.1 2.7 2.5 2.9 2.5 2.7 2.5 2.4 3.0 2.7 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 2.9 2.9 2.9 2.9 2.9 2.9 2.7 2.7 2.7 2.9 2.9 2.9 3.0 3.0 3.0 2.5 2.5 2.5 2.8 2.8 2.8 2.7 2.7 2.7 3.1 3.1 3.1 2.7 2.7 2.7 2.5 2.9a 2.5 2.9 2.9 2.9 2.5 2.5 2.5 2.7 2.7 2.7 2.5 2.5 2.5 2.4 2.4 2.4 3.0 3.0 3.0 2.7 2.7 2.7 *Rat was inadvertently give an additional 0.4 mL. -541 - Gavage ml Day 91 3.0 3.0 2.8 3.0 3.1 2.5 2.8 2.8 3.2 2.7 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: ile Gavage ml Day 84 Gavage ml Day 85 Male, VII: 1 0 0 0 mg/kg 665095 2.5 2.5 665031 2 . 8 2 . 8 665146 2.9 2.9 665062 3.0 3.0 665138 2.3 2.3 665112 2.7 2.7 665007 3.0 3.0 Gavage ml Day 86 2.5 2.8 2.9 3.0 2.3 2.7 3.0 Gavage ml Day 87 2.5 2.8 2.9 3.0 2.3 2.7 3.0 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 2.5 2.5 2.5 2.8 2.8 2.8 2.9 2.9 2.9 3.0 3.0 3.0 2.3 2.3 2.3 2.7 2.7 2.7 3.0 3.0 3.0 -542- Gavage ml Day 91 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 0 Gavage ml Day 1 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 . 665264 665185 665206 665306 665226 665198 665249' 665284 665240 665201 665197 665256 665323 665276 0.9 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.9 0.8 0.9 0.8 0.7 0.9 0.8 01..08 0.9 0.8 0.8 0.9 10..09 0.9 0.9 01..09 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.9 0.8 0.9 0.8 0.7 0.9 0.8 01..08 0.9 0.8 0.8 0.9 01..09 0.9 0.9 10..09 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 Gavage ml Day 2 0.9 0.8 0.9 0.8 0.9 0.9 0.9 . 0.9 0.9 0.8 0.9 0.8 0.7 0.9 0.8 01..08 0.9 0.8 0.8 0.9 10..09 0.9 0.9 01..09 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 Gavage ml Day 3 0.9 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.9 0.8 0.9 0.8 0.7 0.9 0.8 01..08 0.9 0.8 0.8 0.9 01..09 0.9 0.9 01..09 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 0.9 0.9 , 0.9 0.8 0.9 0.8 0.9 0.8 0 .9 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.9 0.9 0.9 0.8 0.8 0.8 0.7 0.7 0.7 0.9 0.9 0.9 0.8 0.8 0.8 1.0 1-00.8 0.8 0 .8 1 .0 0.9 0.9 0.9 0 . 8 0 . 8 0 .8 0.8 0.8 0.8 0.9 0.9 0.9 01..09 01..09 10..09 0.9 0.9 0.9 0.9 0.9 0.9 1.0 1.00.9 0.9 0.9 1.0 0.8 0.8 0.8 0.8 0.8 0.8 0.9 0.9 0 .9 0.9 0.9 0 .9 0.9 0.9 0 .9 0.9 0.9 0.9 0.9 0.9 0 .9 0.9 0.9 0.9 0 . 8 0. 8 0 .8 0 . 8 0 . 8 0 .8 0. 8 0. 8 0 .8 0.8 0.8 0.8 -543- ( DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1 .0 . 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 l'.l 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 0 Gavage ml Day 1 Female, II 0 mg/kg 665228 0.9 0.9 665260 0.9 0.9 665189 0.9 0.9 665204 0.9 0.9 665327 0 . 8 0 . 8 665203 0 . 8 0 . 8 Gayage ml Day 2 0.9 0.9 0.9 0.9 0.8 0.8 Gavage ml Day 3 0.9 0.9 0.9 0.9 0.8 0.8 Gavage ml Day 4 0.9 0.9 0.9 0.9 0.8 0.8 Gavage ml Day 5 0.9 0.9 0.9 0.9 0.8 0.8 Gavage ml Day 6 0.9 0.9 0.9 0.9 0.8 0.8 -544- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.1 1.1 1.1 1 . 0.9 0.9 1.1 1.1 1.1 1.0 0.9 0.9 1.1 1.1 1.1 1.0 0.9 0.9 1.1 1.1 1.1 1.0 0.9 0.9 1.1 1.1 1.1 1.0 0.9 0.9 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 0 Gavage ml Day 1 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324' 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 Gavage ml Day 2 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 . 0.8 0.8 0.8 0.9 0.8 0.7 0.9 Gavage ml Day 3 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 . 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 1.0 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.9 0.8 0.8 0.8 1.0 0.8 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.8 0.8 0.8 0.9 0.8 0.7 0.9 ( (-545- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.1 1 . 1 1.1 1.1 1.1 0.8 0.8 0.8 0.8 0.8 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.1 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.1 1.1 1 . 1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 1.1 0.9 0.9 0.9 0.9 0.9 1.1 1.1 1.1 1 . 1 1.1 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1 . 1 1.1 1.1 1 . 1 1.1 1.0 1.0 1.0 1.0 1.0 1.1 1.1 1 . 1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 0.7 0.7 0.7 0.7 0.7 1.0 1.0 1.0 1.0 1.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: fein Gavage ml Day 0 Gavage ml Day 1 Female, VI 100 mg/kg 665295 0.9 0.9 665251 0 . 8 0 . 8 665300 0.9 0.9 665340 0 . 8 0 . 8 665259 0.9 0.9 665341 0.9 0.9 665199 0.9 0.9 665238 0.9 0.9 665250 0 . 8 0 . 8 665170 0 . 8 0 . 8 665313 0.9 0.9 665233 0.9 0.9 665216 0 . 8 0.8 665266 0.9 0.9 665270 0.9 0.9 665338 0.7 0.7 66529 0 . 8 0 . 8 665267 0.9 0.9 665325 0 . 8 0 . 8 665331 0 .9 0.9 665217 0.9 0.9 665227 0 .9 0.9 665262 0.9 0.9 665247 1 .0 1 . 0 665243' 0 .9 0.9 665312 0 . 8 0 . 8 665298 1 . 0 1 . 0 665207 1 . 0 1 . 0 665273 0.9 0.9 665274 0 . 8 0 . 8 665272 0.9 0.9 665195 0.9 0.9 665314 0.9 0.9 665316 0 . 8 0.8 665173 0.9 0.9 Gavage ml Day 2 0.9 0.8 0.9 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.9 0.9 0.8 0.9 0.9 0.7 0.8 0.9 0.8 0.9 0.9 0.9 0.9 1.0 0.9 0.8 1.0 1.0 0.9 0.8 0.9 0.9 ' 0.9 0.8 0.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 3 Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.7 0.7 0.7 0.7 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9. 0.9 0.9 0,9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0 .9 0.8 0.8 0.8 0.8 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 0.8 0.8 0.9 0.9 0.9 0.9 -546- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 1.1 0.9 1.0 0.9 1.0 1.1 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.1 0.9 1.0 1.0 1.0 1.0 1.1 1.0 0.9 1.1 1.1 1.0 0.9 0.9 1.0 1.0 0.9 1.0 1.1 0.9 1.0 0.9 1.0 1.1 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.1 0.9 1.0 1.0 1.0 1.0 1.1 1.0 0.9 1.1 1.1 1.0 0.9 0.9 1.0 1.0 0.9 1.0 1.1 0.9 1.0 0.9 1.0 1.1 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.1 0.9 1.0 1.0 1.0 1.0 1 .1- 1.0 0.9 1.1 1.1 1.0 0.9 0.9 1.0 1.0 0.9 1.0 1.1 0.9 1.0 0.9 1.0 1.1 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.1 0.9 1.0 1.0 1.0 1.0 1.1 1.0 0.9 1.1 1.1 1.0 0.9 0.9 1.0 1.0 0.9 1.0 1.1 0.9 1.0 0.9 1.0 1.1 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 0.9 0.8 0.9 1.1 0.9 1.0 1.0 1.0 1.0 1.1 1.0 0.9 1.1 1.1 1.0 0.9 0.9 1.0 1.0 0.9 1.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 0 Gavage ml Day 1 Female, VIII 1000 mg/kg 665234 0.9 0.9 665242 0 . 8 0.8 665183 0 . 8 0.8 665261 0 . 8 0.8 665291 0.9 0.9 665337 0 . 8 0 . 8 665333 0.9 0.9 665200 0.9 0.9 665310 0.9 0.9 665326 0 . 8 0 . 8 665302 0 . 8 0 . 8 665179 0.9 0.9 665287 0 . 8 0 . 8 665172 0.9 0.9 665194 0 . 8 0 . 8 665296 0 . 8 0 . 8 665193 1 . 0 1 . 0 665320 0 . 8 0 . 8 665315 0 . 8 0 . 8 665318 0.9 0.9 665279 0.9 0.9 665224 0.9 0.9 665254 0.9 0.9 665245 0.9 0.9 665322 0.9 0.9 665214 0.9 0.9 665321 0 . 8 0 . 8 665171 0 . 8 0 . 8 665265 1 . 0 1 . 0 665169 0 . 8 0 . 8 665191 0 . 8 0.8 665231 0 . 8 0.8 665288 0.9 0.9 665282 0.9 0.9 665275 0 . 8 0.8 665229 0 . 8 0 . 8 665237 0 . 8 0.8 665209 0 . 8 0 . 8 665335 0 . 8 0 . 8 Gavage ml Day 2 0.9 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.8 0.8 1.0 0.8 0.8 * 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 1.0 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.8 0.8 0.8 Gavage ml Day 3 0.9 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.8 0.8 1.0 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 1.0 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.8 0.8 0.8 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 0.9 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.8 0.8 1.0 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 1.0 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.8 0.8 0.8 0.9 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.8 0.8 1.0 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 1.0 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.8 0.8 0.8 0.9 0.8 0.8 0.8 0.9 0.8 0.9 0.9 0.9 0.8 0.8 0.9 0.8 0.9 0.8 0.8 1.0 0.8 0.8 0.9 0.9 0.9 0.9 0.9 0.9 0.9 0.8 0.8 1.0 0.8 0.8 0.8 0.9 0.9 0.8 0.8 0.8 0.8 0.8 -547- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml *Day 10 Gavage ml Day 11 1.0 1.0 0.9 1.0 1.0 0.9 1.0 1.0 1.0 0.9 0.9 1.0 0.9 1.0 0.9 0.8 1.1 0.9 0.9 1.0 1.0 1.1 1.0 1.0 1.0 1.0 0.8 1.0 1.1 0.9 0.9 0.9 1.0 1.1 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 1.0 1.0 0.9 0.9 1.0 0.9 1.0 0.9 0.8 1.1 0.9 0.9 1.0 1.0 1.1 1.0 1.0 1.0 1.0 0.8 1.0 1.1 0.9 0.9 0.9 1.0 1.1 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 1.0 1.0 0.9 0.9 1.0 0.9 1.0 0.9 0.8 1.1 0.9 0.9 1.0 1.0 1.1 1.0 1 .0. 1.0 1.0 0.8 1.0 1.1 0.9 0.9 0.9 1.0 1.1 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 1.0 1.0 0.9 0.9 1.0 0.9 1.0 0.9 0.8 1.1 0.9 0.9 1.0 1-0 1.1 1.0 1.0 1.0 1.0 0.8 1.0 1.1 0.9 0.9 0.9 1.0 1.1 0.9 0.9 0.9 0.9 1.0 1.0 1.0 0.9 1.0 1.0 0.9 1.0 1.0 1.0 0.9 0.9 1.0 0.9 1.0 0.9 0.8 1.1 0.9 0.9 1.0 1.0 1.1 1.0 1.0 1.0 1.0 0.8 1.0 1.1 0.9 0.9 0.9 1.0 1.1 0.9 0.9 0.9 0.9 1.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 0 Gavage ml Day 1 Female-, VIII 1000 mg /kg 665303 0 . 8 0 . 8 665328 0.9 0.9 665299 0 . 8 0 . 8 665255 1 . 0 1 . 0 665213 0.9 0.9 665280 0.9 0.9 Gavage ml Day 2 0.8 0.9 0.8 1.0 0.9 0.9 Gavage ml Day 3 0.8 0.9 0.8 1.0 0.9 0.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 4 Gavage ml Day 5 Gavage ml Day 6 0.8 0.9 0.8 1.0 0.9 0.9 0.8 0.9 0.8 1.0 0.9 0.9 0.8 0.9 0.8 1.0 0.9 0.9 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 7 Gavage ml Day 8 Gavage ml Day 9 Gavage ml Day 10 Gavage ml Day 11 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 1.0 1.0 1.1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 12 Gavage ml Day 13 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257' 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 1.0 0.9 1.0 0.9 1.0 1.0 1.0 1.0 1.1 0.9 1.0 1.0 0.8 1.0 0.9 0.9 1.0 1.1 0.9 0.9 1.0 0.9 1.1 1.0 1.0 1.1 1.0 0.9 0.9 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9 1.0 Gavage ml Day 14 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 * 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 Gavage ml Day 15 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 Gavage ml Day 16 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 Gavage ml Day 17 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 Gavage ml Day 18 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 -549- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 1.1 1.0 1.1 1.0 1.1 1.1 1.1 1.1 1.2 1.0 1.1 1.0 0.8 1.1 1.0 1.0 1.1 1.1 1.0 1.0 1.1 1.0 1.2 1.1 1.1 1.2 1.2 1.0 1.0 1.0 1.1 1.0 1.1 1.0 1.1 1.0 1.0 1.0 1.1 1.3 1.0 1.3 1.1 1.3 1.2 1.2 1.2 1.3 1.1 1.1 1.1 0.9 1.2 1.0 1.1 1.3 1.2 1.1 1.1 1.2 1.2 1.4 1 .2 . 1.2 1.3 1.3 1.2 1.1 1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.1 1.1 1.2 1.3 1.0 1.3 1.1 1.3 1.2 1.2 1.2 1.3 1.1 1.1 1.1 0.9 1.2 1.0 1.1 1.3 1.2 1.1 1.1 1.2 1.2 1.4 1.2 1.2 1.3 1.3 1.2 1.1 1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.1 1.1 1.2 1.3 1.0 1.3 1.1 1.3 1.2 1.2 1.2 1.3 1.1 1.1 1.1 0.9 1.2 1.0 1.1 1.3 1.2 1.1 1.1 1.2 1.2 1.4 1.2 1.2 1.3 1.3 1.2 1.1 1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.1 1.1 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Eem Gavage ml Day 12 Gavage ml Day 13 Female,. II 0 mg/kg 665228 665260 665189 665204 665327. 665203 1.1 1.1 1.1 1.0 0.9 0.9 1.1 1.1 1.1 1.0 0.9 0.9 Gavage ml Day 14 1.2 1.4 1.4 1.1 1.0 0.9 Gavage ml Day 15 1.2 1.4 1.4 1.1 1.0 0.9 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 1.2 1.4 1.4 1.1 1.0 0.9 1.2 1.4 1.4 1.1 1.0 0.9 1.2 1.4 1.4 1.1 1.0 0.9 -550- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.2 1.4 1.4 1.1 1.0 0.9 1.2 1.4 1.4 1.1 1.0 0.9 1.4 1.3 1.3 1.2 1.1 1.0 1.4 1.3 1.3 1.2 1.1 1.0 1 1 1 1 1 1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: fem Gavage ml Day 12 Gavage ml Day 13 Female, IV 10 mg/kg 665308 l.i l.i 665215 0 . 8 0 . 8 665277 1 . 0 1 . 0 665241 0.9 0.9 665236 1.1 1 . 1 665324 1 . 0 1 . 0 665332 1.1 1.1 665239 1 . 0 1 . 0 665182 0.9 0.9 665268 0.9 0.9 665218 0.9 0.9 665309 1 . 0 1 . 0 665177 1 . 0 1 . 0 665202 0.9 0.9 665235 0.9 0.9 665212 0.9 0.9 665180 1 . 0 1 . 0 665292 1 . 1 1 . 1 665187 0.9 0.9 665205 1 . 1 1.1 665263 1 . 0 1 . 0 665210 0.9 0.9 665181 1 . 0 1 . 0 665248 1 . 1 1 . 1 665293 1 . 0 1 . 0 665329 1.1 1.1 665290 1.1 1.1 665253 1.1 1.1 665286 0.9 0.9 665281 0.9 0.9 665186 0.9 0.9 665330 1 . 0 1 . 0 665294 0.9 0.9 665244 0.7 0.7 665258 1.0 1 . 0 Gavage ml Day 14 Gavage ml Day 15 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 , 1.0 1.0 1.0 1.2 - 1.0 1.2 1.1 1.0 "1 . 1 1.2 1.1 1.2 1.3 1.3 1.0 0.9 1.0 1.0 1.0 0.9 1.0 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1.2 1.3 1.3 1.0 0.9 1.0 1.0 1.0 0.9 1.0 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1.2 1.3 1.3 1.0 0.9 1.0 1.0 1.0 0.9 1.0 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1 .2 1.3 1 .3 1 .0 0.9 1.0 1.0 1 .0 ` 0.9 1.0 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1 .0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1 .2 1 .3 1 .3 1 .0 0.9 1 .0 1 .0 1 .0 0 .9 1.0 ( -551 - DuPont-11418 Company Sanitized. Does not contain TSCA C B I Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1.2 1.3 1.3 1.0 0.9 1.0 1.0 1.0 0.9 1.0 1.1 0.9 1.1 1.0 1.2 1.1 1.2 1.1 1.0 1.1 1.0 1.0 1.1 1.0 1.0 1.0 1.0 1.2 1.0 1.2 1.1 1.0 1.1 1.2 1.1 1.2 1.3 1.3 1.0 0.9 1.0 1.0 1.0 0.9 1.0 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES ml Day 12 ml Day 13 Female, VI 100 mg/kg 665295 1 . 1 1.1 665251 0.9 0.9 665300 1.0 1 . 0 665340 0.9 0.9 665259 1 . 0 1 . 0 665341 1.1 1 . 1 665199 1 . 0 1 . 0 665238 1 . 0 1 . 0 665250 1 . 0 1 . 0 665170 0.9 0.9 '665313 1.0 1 . 0 665233 1 . 0 1 . 0 665216 0.9 0.9 665266 1 . 0 1 . 0 665270 0.9 0.9 665338 0 . 8 0 . 8 665219 0.9 0.9 665267 1 . 1 1.1 665325 0.9 0.9 665331 1.0 1.0 665217 1 . 0 1 . 0 665227 1.0 1 . 0 665262 1 . 0 1 . 0 665247 1.1 1 . 1 665243 1 . 0 1 . 0 665312 0.9 0.9 665298 1.1 1 . 1 665207 1 . 1 1 . 1 665273 1 . 0 1 . 0 665274 0.9 0.9 665272 0.9 0.9 665195 1 . 0 1 . 0 665314 1 . 0 1 . 0 665316 0.9 0.9 665173 1 . 0 1 . 0 ml Day 14 1.2 1.0 ` 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 . 0.9 1.1 Gavage ml Day 15 1.2 1.0 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 Gavage ml Day 16 1.2 1.0 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 Gavage ml Day 17 1.2 1.0 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 Gavage ml Day 18 1.2 1.0 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 . 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml * Day 22 Gavage ml Day 23 1.2 1.0 1.1 1.0 1 .1 ' 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 1.2 1.0 1.1 1.0 1.1 1.1 1.0 1.1 1.0 1.0 1.2 1.1 1.0 1.0 1.1 0.9 0.9 1.2 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.2 1.3 1.1 1.0 1.1 1.0 1.1 0.9 1.1 1.3 1.1 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 1.3 1.1 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 1.3 1.1 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1 .1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study 'em Gavage ml Day 12 Gavage ml Day 13 Female, VIII 1000 mg/kg 665234 1 . 0 1 . 0 665242 1.0 1 . 0 665183 0.9 0.9 665261 1 . 0 1 . 0 665291 1 . 0 1 . 0 665337 0.9 0.9 665333 1 . 0 1 . 0 665200 1 . 0 1.0 665310 1 . 0 1 . 0 665326 0.9 0.9 665302 0.9 0.9 665179 1 . 0 1 . 0 665287 0.9 0.9 665172 1 . 0 1 . 0 665194 0.9 0.9 665296 0 . 8 0 . 8 665193 1 . 1 1.1 665320 0.9 0.9 665315 0.9 0.9 665318 1 . 0 1.0 665279 1 . 0 1 . 0 665224 1.1 1.1 665254 1 . 0 1 . 0 665245 1 . 0 1 . 0 665322 1 . 0 1 . 0 665214 1.0 1 . 0 665321 0 . 8 0 . 8 665171 1 . 0 1.0 665265 1.1 1.1 665169 0.9 0.9 665191 0.9 0.9 665231 0.9 0.9 665288 1 . 0 1 . 0 665282 1 . 1 1 . 1 665275 0.9 0.9 665229 0.9 0.9 665237 0.9 0.9 665209 0.9 0.9 665335 1 . 0 1.0 Gavage ml Day 14 1.1 1.1 1.0 1.1 1.1 0.9 1.0 1.2 1.1 i.O 1.0 1.1 1.0 1.1 0.9 0.8 1.2 0.9 0.9 1.1 . 1 -1 1.2 1.1 1.1 1.1 1.1 0.9 1.1 1.2 1.0 1.0 1.0 1.1 1.2 1.0 1.0 1.0 1.0 1.1 Gavage ml Day 15 1.1 1.1 1.0 1.1 1.1 0.9 1.0 1.2 1.1 1.0 1.0 1.1 1.0 1.1 0.9 0.8 1.2 0.9 0.9 1.1 1.1 1.2 1.1 1.1 1.1 1.1 0.9 1.1 1.2 1.0 1.0 1.0 1.1 1.2 1.0 1.0 1.0 1.0 1.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ini Day 17 Gavage ml Day 18 1.1 1.1 1.0 1.1 1.1 0.9 1.0 1.2 1.1 1.0 1.0 1.1 1.0 1.1 0.9 0.8 1.2 0.9 0.9 1.1 1.1 1.2 1.1 1.1 1.1 1.1 0.9 1.1 1.2 . 1.0 1.0 1.0 1.1 1.2 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.0 1.1 1.1 0.9 1.0 1.2 1.1 1.0 1.0 1.1 1.0 1.1 0.9 0.8 1.2 0.9 0.9 1.1 1.1 1.2 1.1 1.1 1.1 1.1 0.9 1.1 1.2 1-0 1.6 1.0 1.1 1.2 1.0 1.0 1.0 1.0 1.1 i l.l 1.1 1.0 1.1 1.1 0.9 , 1.0 1.2 1.1 1.0 1.0 1.1 1.0 1.1 0.9 0.8 1.2 0.9 0 .9 1.1 1.1 1.2 1.1 1.1 1.1 1.1 0 .9 1.1 1.2 1.0 1.0 1 .0 1.1 1.2 1.0 1.0 1.0 1.0 1.1 ( -553 - DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1 . 0 1 . 0 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.3 1.3 1.3 0.9 0.9 1.0 1 . 0 1 . 0 1 . 0 1.0 1.1 1.1 1.1 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1 . 0 1 . 0 1.1 1.1 1.1 1.Q 1.0 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1 . 0 1 .0 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 0.9 0.9 1 . 0 1 . 0 1 . 0 0.8 0.8 0.9 0.9 0.9 1 .2 1.2 1.3 1.3 1.3 0.9 0.9 1.1 1. 1 1.1 0.9 0.9 1.0 1 . 0 1 . 0 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.3 1.3 1.3 1.2 1 . 2 1.3 1.3 1.3 1.1 1 .1 1.3 1.3 1.3 1.1 1. 1 1.1 1 . 1 1 . 1 1.1 1.1 1.1 1 . 1 1.1 1.1 1.1 1.2 1.2 1.2 0.9 0.9 1 . 0 1 . 0 1 . 0 1.1 1.1 1.2 1.2 1.2 1 .2 1.2 1.4 1.4 1.4 1.0 1.0 1.0 1.0 1.0 1 . 0 1. 0 1.1 1 . 1 1 . 1 1 . 0 1 . 0 1.1 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.0 1 . 0 1.1 1.1 1.1 1 . 0 1 . 0 1.1 1.1 1 . 1 1 .0 1 . 0 1.1 1.1 1.1 1 .0 1.0 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study :em Gavage ml Day 12 Gavage ml Day 13 Female, VIII 1000 mg/kg 665303 0.9 0.9 665328 1 . 0 1 . 0 665299 1 . 0 1 . 0 665255 1 . 0 1 . 0 665213 1 . 0 1 . 0 665280 1 . 1 1 . 1 Gavage ml Day 14 0.9 1.1 1.1 1.1 1.1 1.1 Gavage ml Day 15 0.9 1.1 1.1 1.1 1.1 1.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 16 Gavage ml Day 17 Gavage ml Day 18 0.9 1.1 1.1 1.1 1.1 1.1 0.9 1.1 1.1 1.1 1.1 1.1 0.9 1.1 1.1 1.1 1.1 1.1 -554- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 19 Gavage ml Day 20 Gavage ml Day 21 Gavage ml Day 22 Gavage ml Day 23 0.9 1.1 1.1 1.1 1.1 1.1 0.9 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.1 1.3 1.2 1.3 1.1 1.2 1.1 1.3 1.2 1.3 l.: l. 1. 1. 1. 1. ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 24 Gavage ml Day 25 Female, II 0 mg/kg 665211 1.3 1.3 665271 1.0 1 . 0 665178 1.3 1.3 665317 1.1 1 . 1 665230 1.3 1.3 665225 1.2 1.2 665174 1.2 1 . 2 665319 1.2 1.2 665221 1.3 1.3 665278 1.1 1.1 665176 1.1 1.1 665283 1.1 1.1 665297 0.9 0.9 665301 1.2 1 . 2 665269 1 . 0 1 . 0 665220 1.1 1 . 1 665334 1.3 1.3 665257 1 . 2 1 . 2 665175 1.1 1.1 665336 1.1 1.1 665192 1.2 1.2 665232 1.2 1 . 2 665307 1.4 1.4 665246 1 . 2 1.2 665289 1.2 1 . 2 665264 1.3 1.3 665185 1.3 1.3 665206 1.2 1 . 2 665306 1.1 1 . 1 665226 1.1 1 . 1 665198 1.1 1.1 665249 1 . 2 1 . 2 665284 1.2 1.2 665240 1.1 1 . 1 665201 1 . 2 1 . 2 665197 1.1 1.1 665256 1.1 1 . 1 665323 1.1 1.1 665276 1.2 1.2 Gavage ml Day 26 1.3 1.0 1.3 1.1 1.3 1.2 1.2 1.2 1.3 1.1 1.1 1.1 0.9 1.2 1.0 1.1 1 .3 1.2 1.1 1.1 1.2 1.2 1.4 1.2 1.2 1.3 * 1.3 1.2 1.1 1.1 1.1 1 .2 1.2 1.1 1.2 1.1 1.1 1.1 1.2 Gavage ml Day 27 1.3 1.0 1.3 1.1 1.3 1.2 1.2 1.2 1.3 1.1 1.1 1.1 0.9 1.2 1.0 1.1 1.3 1.2 1.1 1.1 1.2 1.2 1.4 1.2 1.2 1.3 1.3 1.2 1.1 1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.1 1.1 1.2 Gavage ml Day 28 1.4 1.1 1.3 1.2 1.4 1.3 1.3 1.3 1.3 1.1 1.3 1.2 1.0 1.3 1.1 1.2 1.4 1.3 1.1 1.2 1.3 1.3 1.4 1.3 1.3 1.4 1.4 1.3 1.1 , 1-2 1.2 1.3 1.3 1.2 1.3 1.2 1.2 1.2 1.3 Gavage ml Day 29 1.4 1.1 1.3 1.2 1.4 1.3 1.3 1.3 1.3 1.1 1.3 1.2 1.0 1.3 1.1 1.2 1.4 1.3 1.1 1.2 1.3 1.3 1.4 1.3 1.3 1.4 1.4 1.3 1.1 1.2 1.2 1.3 1.3 1.2 1.3 1.2 1.2 1.2 1.3 Gavage ml Day 30 1.4 1.1 1.3 1.2 1.4 1.3 1.3 1.3 1.3 1.1 1.3 1.2 1.0 1.3 1.1 1.2 1.4 1.3 1.1 1.2 1.3 1.3 1.4 1.3 1.3 1.4 1.4 1.3 1.1 1.2 1.2 1.3 1.3 1.2 1.3 1.2 1.2 1.2 1.3 -555- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.4 1.4 1.4 1.4 1.5 1.1 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.4 1 . 2 1 . 2 1 . 2 1 . 2 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.1 1.1 1.1 1.1 1.2 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.0 1.3 1.1 1.2 1.4 1.3 1.0 1.3 1.1 1.2 1.4 1.3 1.0 1.3 1.1 1.2 1.4 1.3 1.0 1.3 1.1 1.2 1.4 1.3 1.0 1.3 1.1 1.2 1.4 1.3 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1. 2 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.2 1. 2 1 . 2 1 . 2 1 . 2 1.3 1.2 1.2 1.2 . 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.4 1.2 1.2 1.2 1.2 1.2 1. 2 1 . 2 1 . 2 1 . 2 1.3 1. 2 1. 2 1. 2 1. 2 1.3 1.3 1.3 1.3 1.3 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study Gavage ml Day 24 :em Gavage ml Day 25 Gavage ml Day 26 Gavage ml Day 27 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 Female, II 0 mg/kg 665228 1.4 1.4 1.4 1.4 1.5 1.5 1.5 665260 1.3 1.3 1.3 1.3 1.4 1.4 1.4 665189 1.3 1.3 1.3 1.3 1.5 1.5 1.5 665204 1.2 1.2 1.2 1 . 2 1.3 1.3 1.3 665327 1. 1 1. 1 1.1 1. 1 1 . 2 1 . 2 1 . 2 665203 1. 0 1 . 0 1. 0 1 . 0 1 . 1 1 . 1 1 . 1 - 556- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1 . 2 1 . 2 1 . 2 1 . 2 1.3 1.1 1.1 1.1 1.1 1.1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study :em Gavage ml Day 24 Gavage ml Day 25 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329, 665290 665253 665286 665281 665186 665330 665294 665244 665258 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 Gavage ml Day 26 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 . 1.0 1.1 Gavage ml Day 27 1.3 1.1 1.1 1.1 1.3 1.1 1.3 1.2 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.4 1.1 1.3 1.3 1.2 1.2 1.3 1.1 1.3 1.4 1.4 1.1 1.0 1.0 1.2 1.1 1.0 1.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.4 1.2 1.4 1.5 1.5 1.1 1.0 1.1 1.2 1.2 1.0 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1 -3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1 .4 1.2 1.3 1.4 1.2 1 .4 1 .5 1.5 1.1 1 .0 1.1 1.2 1.2 1 .0 1.2 1.4 1 .1 1.2 1 .2 1 .4 1 .2 1 .4 1 .3 1 .3 1 .3 1.2 1 .3 1 .3 1 .2 1 .2 1 .2 1 .2 1 .5 1 .2 1 .4 1 .4 1 .2 1 .3 1 .4 1 .2 1 .4 1 .5 1-5 1 .1 1 .0 1 .1 1.2 1 .2 1 .0 1.2 -557- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavac e ml Day 55 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.4 1.2 1.4 1.5 1.5 1.1 1.0 1.1 1.2 1.2 1.0 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1-3 1.3 1.3 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.4 1.2 1.4 1.5 1.5 1.1 1.0 1.1 1.2 1.2 1.0 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.4 1.2 1.4 1.5 1.5 1.1 1.0 1.1 1.2 1.2 1.0 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.3 1.2 1.2 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.4 1.2 1.4 1.5 1.5 Xt .1X 1.0 1.1 1.2 1.2 1.0 1.2 1.4 1.1 1.3 1.2 1 .5 1.3 I .4 .1.3 : .2 : .4 : .3 : .3 : .3 1.2 1.3 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 1.3 1.1 _. 2 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory * Study:] :em Gavage ml Day 24 Gavage ml :Day 25 .Female, VI 100 mg/kg 665295 665251 665300 665340 665259 ^65341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 1.3 1.1 1.2 V1.1 1.2 * 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 1.3 1.1 1.2 11 .-21 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 Gavage ml Day 26 1.3 1.1 1.2 1.1 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 . 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 1.1 1.2 1.2 1.2 1.0 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 27 Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 1.3 1.1 1.2 * 1.1 ' 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.1 1.2 0.9 1.1 1.3 1.1 1.2 1.2 1.2 1.3 1.2 1.2 1.1 1.3 1.4 1.2 ' 1.1 1.2 1.2 1.2 1.0 1.2 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 ' . 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 -558- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 31 Gavagw ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 1.4 1.2 1.3 1.1 1.3 113 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 1.4 1.2 1.3 1.1 1.3 1.3 . 1.3 f 1.4 1.2 1.2 1.4 1.3 1.3 1.2 1.2 1.0 1.1 1.3 1.1 1.3 1.3 1.3 1.4 1.3 1.3 1.2 1.4 1.5 1.3 1.1 1.2 1.2 1.3 1.1 1.3 1.4 1.2 1.4 1.1 1.3 1.3 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.0 1.2 1.4 1.1 1.3 1.4 1.4 1.4 1.4 1.3 1.2 1.4 1.5 1.3 1.2 1.3 1.3 1.4 1.1 1.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study :em Gavage ml Day 24 Gavage ml Day 25 Female, VIII 1000 mg/kg 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229 665237 665209 665335 1.2 1.2 1.2 1.2 1.1 1.1 1.2 1.2 11..03 11..03 1.1 1.1 1.3 1.3 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.2 1.1 1.1 11..02 11..02 0.9 0.9 1.3 1.3 11..01 11..01 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 11..02 11..02 1.2 1.2 11..04 11..04 1.1 1.1 1.1 1.3 1.2 1.1 1.1 1.1 1.1 1.2 1.1 1.3 1.2 1.1 1.1 1.1 1.1 1.2 Gavage ml Day 26 1.2 1.2 1.1 1.2 11..03 1.1 1.3 1.2 1.1 1.1 1.2 1.1 11..02 0.9 1.3 11..01 1.2 1.3 1.3 1.3 1.1 1.1 11..02 1.2 11..04 1.1 1.1 1.3 1.2 1.1 1.1 1.1 1.1 1.2 Gavage ml Day 27 1.2 1.2 1.1 1.2 11..03 1.1 1.3 1.2 1.1 1.1 1.2 1.1 11..02 0.9 1.3 11..01 1.2 1.3 1.3 1.3 1.1 1.1 11..02 1.2 11..04 1.1 1.1 1.3 1.2 1.1 1.1 1.1 1.1 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 28 Gavage ml Day 29 Gavage ml Day 30 1.3 1.3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1.3 1.2 1.3 1.1 0.9 1.3 1.1 1.1 1.3 1.4 1.4 1.3 1.2 1.2 1.3 1.1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1.3 1 .3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1 .3 1 .2 1.3 1.1 0.9 1.3 1.1 1 .1 1.3 1.4 1.4 1.3 1.2 1.2 1 .3 1 .1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1 .3 1 .3 1 .2 1 .2 1 .3 1 .1 1 .2 1 .4 1.4 1 .1 1 .1 1 .3 1 .2 1 .3 1 .1 0 .9 1 .3 1 .1 1 .1 1 .3 1.4 1.4 1 .3 1 .2 1 .2 1 .3 1 .1 1 .3 1 .5 1 .2 1 .2 1 .2 1 .3 1.3 1 .2 1 .2 1 .1 1.2 1.2 -559- ) DuPont-11418 Company Sanitized. Does not contain TSCA C8I Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.3 1.3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1.3 1.2 1.3 1.1 0.9 1.3 1.1 1.1 1.3 1.4 1.4 1.3 1.2 1.2 1.3 1.1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1.3 1.3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1.3 1.2 1.3 1.1 0.9 1.3 1.1 1.1 1.3 1.4 1.4 1.3 1.2 1.2 1.3 1.1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1.3 1.3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1.3 1.2 1.3 1.1 0.9 1.3 1.1 1.1 1.3 1.4 1.4 1.3 1.2 1.2 1.3 1.1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1.3 1.3 1.2 1.2 1.3 1.1 1.2 1.4 1.4 1.1 1.1 1.3 1.2 1.3 1.1 0.9 1.3 1.1 1.1 1.3 1.4 1.4 1.3 1.2 1.2 1.3 1.1 1.3 1.5 1.2 1.2 1.2 1.3 1.3 1.2 1.2 1.1 1.2 1.2 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1.2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1.5 1.4 1.4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 24 Gavage ml Day 25 Female, VIII 1000 mg/kg 665303 1.1 1.1 665328 1.2 1.2 665299 1.1 1 . 1 665255 1.3 1.3 665213 1.2 1 . 2 665280 1.3 1.3 Gavage 'ml Day 26 1.1 1.2 1.1 1.3 1.2 1.3 Gavage ml Day 27 1.1 1.2 1.1 1.3 1.2 1.3 Gavage ml Day 28 1.1 1.2 1.2 1.4 1.2 1.4 Gavage ml Day 29 1.1 1.2 1.2 1.4 1.2 1.4 Gavage ml Day 30 1.1 1.2 1.2 1.4 1.2 1.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBl Gavage ml Day 31 Gavage ml Day 32 Gavage ml Day 33 Gavage ml Day 34 Gavage ml Day 35 1.1 1.2 1.2 1.4 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.1 1.2 1.2 1.4 1.2 1.4 1.1 1-2 1.2 1.4 1.2 1.4 1 1 1 1 1 1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study:] Ifem Gavage ml Day 36 Gavage ml Day 37 Female, II 0 mg/kg 665211 1.5 1.5 665271 1.1 1 . 1 665178 1.4 1.4 665317 1.3 1.3 665230 1.4 1.4 665225 1.4 1.4 665174 1.4 1.4 665319 1.3 1.3 665221 1.5 1.5 665278 1.2 1 . 2 665176 1.3 1.3 665283 1.2 1.2 665297 1.0 1 . 0 665301 1.3 1.3 665269 1.1 1 . 1 665220 1.2 1.2 665334 1.4 1.4 665257 1.3 1.3 665175 1.2 1.2 665336 1.2 1 . 2 665192 1.3 1.3 665232 1.2 1.2 665307 1.4 1.4 665246 1.4 1.4 665289 1.4 1.4 665264 1.4 1.4 665185 1.4 1.4 665206 1.3 1.3 665306 1.2 1.2 665226 1.3 1.3 665198 1.3 1.3 665249 1.4 1.4 665284 1.3 1.3 665240 1.2 1.2 665201 1.4 1.4 665197 1.2 1 . 2 665256 1.3 1.3 665323 1.3 1.3 665276 1.4 1.4 Gavage ml Day 38 1.5 1.1 1.4 1.3 1.4 1.4 1.4 1-3 1.5 1.2 1.3 1 .2 1.0 1.3 1.1 1.2 1.4 1 .3 1.2 1.2 1.3 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.2 1.3 1.3 1.4 1.3 1.2 1.4 1.2 1-3 1.3 1.4 Gavage ml Day 39 1.5 1.1 1.4 1.3 1.4 1.4 1.4 1.3 1.5 1.2 1.3 1.2 1.0 1.3 1.1 1.2 1.4 1.3 1.2 1.2 1.3 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.2 1.3 1.3 1.4 1.3 1.2 1.4 1.2 1.3 1.3 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 1.5 1.5 1.5 1.1 1.1 1.2 1.4 1.4 1.5 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.4 1.5 1.5 1.4 1.2 1.2 1.2 1.3 1.3 1.4 1.2 1.2 1.2 1.0 1.0 1.0 1.3 1.3 1.4 1.1 1.1 1.2 1.2 1.2 1.2 1.4 1.4 1.5 1.3 1.3 1.3 1 . 2 1.2 1.3 1.2 1.2 1.2 1.3 1.3 1.4 1 . 2 1.2 1.3 1.4 1.4 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.4 1.4 1.5 1.3 1.3 1.4 1 . 2 1 .2 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.3 1.3 1.4 1 . 2 1.2 1.3 1.4 1.4 1.4 1 . 2 1 . 2 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 -561 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.0 1.0 1.0 1.0 1.0 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.6 1.4 1.6 1.4 1.6 1 ,,4 1.6 1.4 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study-.' :em Gavage ml Day 36 Gavage ml Day 37 Female, II 0 mg/kg 665228 1.5 1.5 665260 1.4 1.4 665189 1.5 1.5 665204 1.3 1.3 665327 1.3 1.3 665203 1.1 1.1 Gavage ml Day 38 1.5 1.4 1.5 1.3 1.3 1.1 Gavage ml Day 39 1.5 1.4 1.5 ' 1.3 1.3 1.1 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml ! Day 42 1.5 1.5 1 . 6 1.4 1.4 1'..6 1.5 1.5 I. 5 1.3 1.3 1.3 1.3 1.3 1.3 1.1 1 !1 1.2 -562- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml :Day 45 Gavage ml Day 46 Gavage ml Day 47 1.6 1.6 1.5 1.3 1.3 1.2 1.6 1.6 1.5 1.3 1.3 1.2 1.6 1.6 1.5 1.3 1.3 1.2 1.6 1.6 1.5 1.3 1.3 1.2 1.6 1.6 1.5 1.3 1.3 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study Gavage ml Day 36 Gavage ml Day 37 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177' 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 1.4 1.1 1.3 1.2 1.5 1.3 1.4 1.3 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 1.3 1.1 1.2 1.4 1.1 1.3 1.2 1.5 1.3 1.4 1.3 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 1.3 1.1 1.2 Gavage ml Day 38 1.4 1.1 1.3 1.2 1.5 1.3 1.4 1.3 1-2 1.4 1.3 1.3 1.3 1.2 1.3 1.2 1.2 1.5 1.2 . 1.4 1.4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 .3 l.l 1-2 G<ivage ml Diiy 39 1.4 1.1 1.3 1.2 1.5 1.3 1.4 1.3 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.2 1.2 1.5 1.2 1.4 ; 1.4 1.2 ; 1.3 1.5 1.2 1.4 1.6 1.6 - 1.2 1.1 1.1 1.2 1.3 ! 1.1 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 1.4 1.1 1.3 1.2 1.5 1.3 1.4 1.3 1.2 1.4 1.3 1.3 1.3 1.2 1.3 1.2 1.2 1.5 1.2 1.4 1.4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 1.3 1.1 1.2 1.4 1 . 1 1.3 1.2 1.5 1.3 1.4 1.3 1.2 1.4 1.3 1 .3 1.3 1.2 1.3 1.2 1.2 1 .5 1.2 1.4 1 .4 1.2 1.3 1.5 1.2 1.4 1.6 1.6 1.2 1.1 1.1 1.2 1.3 i .1 1.2 1.5 1.2 1.4 1.3 1.5 1 .3 1.5 1.3 1.3 1 .3 1.4 1 .3 1.4 1 .3 1 .3 .3 1 .3 1.6 1 .3 1 .5 1 .5 1 .3 1*4 1.6 .3 1 .5 1.6 i .6 1 .3 i .1 .2 1.4 1 .3 1.1 1.3 -563- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1 . 2 1.2 1 . 2 1.4 1.4 1.4 1.4 1.4 1.3- 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 -1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1 . 6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1 . 6 1.6 1 . 6 1.6 i .6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1 . 6 1 . 6 1 . 6 1 . 6 1.6 1 . 6 1 . 6 1 . 6 1 . 6 1.6 1.3 1.3 1.3 1.3 1.3 1 . 1 1.1 1 . 1 1 . 1 1.1 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1 . 1 1.1 1 . 1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study :eiu Gavage ml Day 36 Gavage ml Day 37 Female, VI 100 mg/kg 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 1.4 1.2 1.4 1.1 1.3 1.3 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.0 1.2 1.4- 1.1 1.3 1.4 1.4 1.4 1.4 1.3 1.2 1.4 1.5 1.3 1.2 1.3 1.3 1.4 1.1 1.3 1.4 1.2 1.4 1.1 1.3 1.3 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.0 1.2 1.4 1.1 1.3 1.4 1.4 1.4 1.4 1.3 1.2 1.4 1.5 1.3 1.2 1.3 1.3 1.4 1.1 1.3 Gavage ml Day 38 1.4 1.2 1.4 1.1 1.3 1.3 . 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.0 1.2 1.4 1.1 1.3 1.4 1.4 1.4 1.4 1.3 1.2 1.4 1.5 1.3 1.2 1.3 1.3 1.4 1.1 1.3 Gavage ml Day 39 1.4 1.2 1.4 1.1 1.3 1.3 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.0 1.2 1.4 1.1 1.3 1.4 1.4 1.4 1.4 1.3 1.2 1.4 1.5 1.3 1.2 1.3 1.3 1.4 1.1 1.3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml Day 42 1.4 1.4 1.5 1.2 1.4 1.2 1.4 1.2 1.3 1.1 1.1 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1 .3 1.4 1.4 1.4 1.3 1.3 .3 1.2 1.2 1.3 1.4 1.4 1 .5 1.4 1.4 1.4 1.3 1 .3 1 .4 1.2 1.2 1.2 1.3 1.3 1.4 1 . 0 1. 0 1 .0 1. 2 1 .2 1 .2 1.4 1.4 1 .5 1.1 1.1 1.2 1.3 1.3 1 .4 1.4 1.4 1.4 1.4 1 .4 1 .4 1.4 1.4 1 .5 1.4 1.4 1 .5 1.3 1.3 1 .4 1.2 1.2 1.2 1.4 1.4 1 .5 1.5 1.5 1 .5 1.3 1 .3 1 .4 1.2 1.2 1.2 1.3 1.3 1.4 1.3 1.3 1.3 1.4 1.4 1.5 1.1 1.1 1.1 1.3 1.3 1.4 -564- ) DuPont-11418 Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 1.0 1.2 1.5 1.2 1.5 1.2 1.5 1.2 1.5 1.2 1.5 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.2 1.4 1.2 1.4 1.2 1.4 1.2 1.4 1.2 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.1 1.1 1.1 1.4 1.4 1.4 1.4 1.4 Company S a n itiz e d . D o e s not contain CO < 2 > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generatipn Reproduction Evaluations ) Dupont Haskell Laboratory Study:i :em Gavage ml Day 36 Gavage ml Day 37 Female, VIII 1000 mg/kg 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315' 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229 665237 665209 665335 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1.2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1.5 1.4 1.4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1.2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1.5 1.4 1.4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 1.2 Garage ml Day 38 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1_2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1.5 1.4 1.4 1.3 1.3 . 1-3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 1.2 Gavage (ml Dqiy 39 ! 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 i 1.2 . 1.3 1.1 1.0 ; 1.5 1.2 1.2 1.4 1.5 1.4 1-4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1-2 : 1.2 1.2 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml : Day 42 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1.2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1.5 1.4 1.4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.3 1.2 1.4 1.4 1.2 1.2 1.4 1.4 1.2 1.1 1.3 1.2 1.3 1.1 1.0 1.5 1.2 1.2 1.4 1 .5 1.4 1.4 1.3 1.3 1.3 1.1 1.3 1.6 1.2 1.2 1.2 1.4 1.4 1.2 1 .2 1.2 1.2 1.2 1.4 1.3 1.3 1 .4 1 .4 1.2 1.2 1 .4 1 .5 1.2 1.2 1.4 -3 1.3 .2 i .0 1 .5 1.2 -2 1 .4 1 .5 1 .5 1 .5 1 .3 1.3 1.4 1 .2 1.4 ,1.6 1.2 ;i.3 !1.3 1.4 1.5 1.3 1.3 1-2 il.2 1.3 -565- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1.5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1.5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1-5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1.5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1.5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generakion Reproduction Evaluations Dupont Haskell Laboratory Study:' :em Gavage ml Day 36 Gavage ml Day 37 Female, VIII 1000 mg/kg 665303 1.1 1 . 1 665328 1.3 1.3 665299 1.3 1.3 665255 1.4 1.4 665213 1.3 1.3 665280 1.5 1.5 Gavage ml Day 38 1.1 1.3 1.3 1.4 1.3 1.5 Gavage ! ml Day 39 1.1 1.3 1.3 1.4 1.3 ! 1-5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 40 Gavage ml Day 41 Gavage ml' Day '42 1 . 1 1 . 1 T.: 1.3 1.3 !.. 1.3 1.3 a.: 1.4 1.4 a.i 1.3 1.3 i.. 1.5 1.5 l. -566- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 43 Gavage ml Day 44 Gavage ml Day 45 Gavage ml Day 46 Gavage ml Day 47 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study pern Gavage ml Day 48 Gavage ml Day 49 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175. 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 1.5 1.2 1.5 1.3 1.4 1.4 1.4 1.4 1.4 1.2 1.4 1.2 1.0 1.4 1.2 1.2 1.5 1.3 1.3 1.2 1.4 1.3 1.6 1.4 1.4 1.5 1.5 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.3 1.3 1.4 1.4 1.6 1.2 1.6 1.3 1.5 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 1.4 1.3 1.3 1.5 1.4 1.6 1.4 1.4 1.5 1.6 1.4 1.2 1.4 1.4 1.5 1.4 1.3 1.4 1.4 1.4 1.4 1.5 Gavage ml Day 50 > 1.6 1.2 1.6 1.3 1.5 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 1.4 1.3 1.3 1.5 1.4 1.6 1.4 1.4 1.5 1.6 1.4 1.2 1.4 1.4 1.5 1 1.4 1.3 1.4 1-4 1.4 1.4 1.5 Gavage ml Day 51 1.6 1.2 1.6 1.3 1.5 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 1.4 1.3 1.3 1.5 1.4 1.6 1.4 1.4 1.5 1.6 1.4 1.2 1.4 1.4 1.5 1.4 1.3 1.4 1.4 1.4 1.4 1.5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavge ml Day :54 1.6 1.6 :1.6 1.2 1 . 2 il.2 1.6 1.6 1 . 6 1.3 1.3 1.3 1.5 1.5 ;1.5 1.4 1.4 il.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 il.3 1.4 1.4 1.4 1.3 1.3 1.3 1.1 1.1 T.l 1.5 1.5 1.5 1.2 1 . 2 1 . 2 1.3 1.3 il.3 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 '1.4 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 11 .4 1.5 1.5 1.5 1.6 1.6 1.6 1.4 1.4 il.4 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.4 1.4 il.4 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 -567- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day '57 Gavage ml Day 58 Gavage ml Day 59 1.6 1.7 1.7 1.7 1.7 1.2 1.2 1.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 1.3 1.4 1.4 1.4 1.4 1.5 1 . 6 1 . 6 1 . 6 1 . 6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.-5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1 .2 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generatijon Reproduction Evaluations Dupont Haskell Laboratory Study* Gavage ml Day 48 Gavage ml Day 49 Female,, II 0 mg/kg 665228 1.6 1 . 6 665260 1.6 1 . 6 665189 1.5 1 .6 665204 1.3 1.4 665327 1.3 1.3 665203 1.2 1 . 2 Gavage ml Day 50 1.6 1.6 1.6 1.4 1.3 1.2 Gavage Sml Day 51 1.6 1.6 1.6 1.4 1.3 ; 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml i Day 54 1.6 1.6 1.6 1.4 1.3 1.2 1.6 1.6 1.6 1.4 1.3 1.2 1.6 1.6 1.6 1.4 1.3 1.2 - 568 - ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 1.6 1.6 1.6 1.4 1.3 1.2 1.7 1.6 1.6 1.4 1.4 1.2 1.7 1.6 1.6 1.4 1.4 1.2 1.7 1.6 1.6 1.4 1.4 1.2 1.7 1.6 1.6 1.4 1.4 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations i Dupont Haskell Laboratory ; Study:' Gavage ml Day 48 Gavage ml Day 49 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186' 665330 665294 665244 665258 1.5 1.5 1.2 1.2 1.4 1.4 1.3 1.3 1.5 1.6 1.3 1.3 1.5 1.5 1.3 1.4 1.3 1.4 1.3 1.4 1.4 1.4 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.6 1.7 1.3 1.4 1.5 1.5 1.5 1.6 1.3 1.4 1.4 1.4 1.6 1.5 1.3 1.3 1.5 1.5 1.6 1.7 1.6 1.6 1.3 1.4 1.1 1.1 1.2 1.4 1.2 1.4 1.3 1.3 1.1 1.2 1.3 1.3 Gavage ml Day 50 1.5 1.2 1.4 1.3 1.6 1.3 ' 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.4 1.3 1.3 1.7 1.4 1.5 1.6 1.4 1.4 1.5 1.3 1.5 1.7 1.6 1.4 1.1 1.2 1.4 1.3 1.2 1.3 i Gavage { ml Day 51 1.5 : 1.2 1.4 1-3 1 1.6 1.3 1.5 1.4 : 1-4 1.4 ! 1.4 1.4 !1 1.3 1.3 1 1.4 1.3 i 1-3 ! 1.7 1.4 1.5 1.6 1.4 1.4 1.5 1.3 1 1.5 1.7 1.6 ; i.4 i 1.1 i 1.2 ; i.4 1.3 i; i .2 1-3 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 1.5 1.2 1.4 1.3 1.6 1.3 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.4 1.3 1.3 1 .7 1.4 1.5 1.6 1.4 1.4 1.5 1.3 1.5 1.7 1.6 1.4 1.1 1.2 1.4 1.3 1.2 1.3 1.5 1.2 1.4 1.3 1.6 1.3 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1 .4 1 .3 1.3 1 .7 1 .4 1.5 1.6 1.4 1.4 1 .5 1 .3 1 .5 1.7 1.6 1.4 1.1 1.2 1.4 1 .3 1 .2 1.3 1 .5 :1 .2 1.4 11.3 1.6 1.3 ;1.5 :1 .4 1.4 :1 .4 1.4 1.4 1.3 1 .3 i1 .4 1.3 1-3 1.7 1.4 1.5 1.6 1.4 1.4 1.5 1.3 1.5 i1 .7 '1 . 6 1-4 1.1 1-2 :i.4 1,3 `1.2 1.3 Ti -5 6 9 i DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 1.5 1.6 1.6 1.6 1.6 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.7 1.8 1.8 1.8 1.8 1.4 1.4 1.4 1.4 1.4 1.5 .6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1 . 6 1 . 6 1. 6 1 . 6 1.3 1.3 1.-3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1 .6 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.1 1.1 1.1 1.1 1.1 1.2 1 .'2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.3 1.4 1.4 1.4 1.4 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study:' fern Gavage ml Day 48 Gavage ml Day 49 Female, VI 100 mg/kg 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219. 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 1.5 1.2 1.3 1.2 1.3 1.4 1.3 1.4 1.3 1.3 1.5 1.4 1.4 1.2 1.4 1.0 1.2 1.5 1.2 1.4 1.4 1.4 1.5 1.5 1.4 1.2 1.5 1.5 1.4 1.2 1.4 1.3 1.5 1.1 1.4 1.5 1.3 1.4 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.4 1.5 1.2 1.4 1.0 1.3 .6 1.3 1.5 1.5 1.6 1.5 1.6 1.5 1.3 1.5 1.5 1.4 1.3 1.4 1.4 1.5 1.2 1.4 Gavage ml Day 50 1.5 1.3 1.4 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.4 1.5 1.2 1.4 1.0 1.3 1.6 1.3 1.5 1.5 1.6 1.5 1.6 * 1-5 1-3 1.5 1.5 1.4 1.3 1.4 1.4 1.5 1.2 1.4 Gavage ml Day 51 1.5 1.3 1.4 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.4 1.5 1.2 1.4 1.0 1.3 1.6 1.3 1.5 1.5 1.6 1.5 1.6 1.5 1.3 1.5 1.5 1.4 1.3 1.4 1.4 1.5 1.2 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml , Day 54 1.5 1.5 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.5 1.5 1.2 1.2 1.4 1.4 1.0 1.0 1.3 1.3 1.6 1.6 1.3 1.3 1.5 1.5 1.5 1.5 1.6 . 1.6 1.5 1.5 1.6 1.5 1.6 1.5 1.3 1.3 1.5 1.5 1.5 1.5 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.4 1.5 1.5 1.2 1.2 1.4 1.4 1.5 1.3 .4 ' .2 1.4 .4 .4 1.4 .4 1.4 1.5 1.4 1.5 1.2 1.4 1.0 1.3 1.6 1.3 1.5 1.5 1.6 1.5 1.6 1.5 1.3 1.5 1.5 1.4 1.3 1.4 1.4 1.5 1.2 1.4 -570- DuPont-11418 Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 1.5 1.6 1.6 1.6 1.6 1.3 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.4 1.4 f.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.0 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.6 1.5 1.5 1.5 1.5 1.3 1 . 2 1. 2 1 . 2 1 . 2 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.5 1.5 1.5 1 . 6 1.6 1.6 1.6 1. 6 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.3 1-3 1.3 1.3 1.3 1.5 1.5 1.4 1.6 1.6 1.5 1.6 1.6 1.5 1.6 1.6 1.5 1.6 1.6 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.4 1.5 1.5 1.5 1.5 Company Sanitized. Does not 03 O < O CD 'H<c5 +ooc* H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study :em Gavage ml Day 48 Gavage ml Day 49 Female, VIII 1000 mg/kg Gavage ml Day 50 665234 665242 665183 665261 , 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229' 665237 665209 665335 1.4 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.2 1.2 1.4 1.3 1.3 1.2 1.0 1.5 1.2 1.2 1.4 1.5 1.5 1.5 1.3 1.3 1.4 1.2 1.4 1.6 1.2 1.3 1.3 1.4 1.5 1.3 1.3 1.2 1.2 1.3 1.4 1.3 1.3 1.5 1.5 1.3 1.3 1.5 1.5 1.3 1.3 1.4 1.3 1.4 1.2 1.0 1.5 1.2 1.3 1.5 1.6 1.6 1.5 1.4 1.3 1.4 1.2 1.4 1.7 1.3 1.3 1.3 1.5 1.5 1.3 1 -2 . 1.3 1.3 1.4 1.4 1.3 1.3 1.5 1.5 1.3 1.3 1.5 1.5 1.3 1.3 4 1.4 1.3 1.4 1.2 1.0 1.5 1.2 1.3 1.5 1.6 1.6 1.5 1.4 1.3 1.4 1.2 1.4 1.7 1.3 1.3 1.3 1.5 1.5 1.3 1.2 1.3 1.3 1.4 Gvage imi Day 51 1.4 1.3 1.3 1.5 1.5 1.3 1.3 1.5 1.5 1.3 1.3 1.4 1.3 1.4 1.2 1.0 1.5 1.2 1.3 1.5 1.6 1.6 1.5 1.4 1.3 1.4 1.2 1.4 1.7 1.3 1.3 1.3 1.5 1.5 1.3 1.2 1.3 1.3 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 5.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 . 5 1.3 1.3 1.3 1.3 1.3 .3 1.4 1.4 1.4 1.3 1.3 1.3 1.4 1.4 1.4 1.2 1.2 1.2 1 . 0 1 . 0 i.o 1.5 1.5 1.5 1.2 1.2 1.2 1.3 1.3 1.3 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 .1 . 6 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 1.3 1.4 1.4 .1.4 1.2 1.2 1.2 1.4 1.4 1.4 1.7 1.7 1.7 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 . 1.3 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1 . 4 -571 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 1.4 1.5 1.5 1.5 1.5 1.3 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1:6 1.6 1.6 1.3 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.01.0 1.0 1.0 1.0 1.5 1.6 1.6 1.6 1.6 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.5 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.2 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: Ifem Gavage ml Day 48 Gavage ml Day 49 Female, VIII 1000 mg/kg 665303 1.2 1.2 665328 1.4 1.4 665299 1.3 1.4 665255 1.5 1.5 665213 1.4 1.4 665280 1.5 1.6 Gavage ml Day 50 , 1.2 1.4 1.4 1.5 1.4 1.6 Gavage ml Day 51 1.2 1.4 1.4 1.5 1.4 1.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 52 Gavage ml Day 53 Gavage ml Day 54 1.2 1.2 1.2 1.4 1.4 4 1.4 1.4 1.4 1.5 1.5 .5 1.4 1.4 .4 1.6 1.6 1.6 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 55 Gavage ml Day 56 Gavage ml Day 57 Gavage ml Day 58 Gavage ml Day 59 1.2 1.3 1.3 1.3 1 1.4 1.4 1.4 1.4 1 1.4 1.3 1.3 1.3 1 1.5 1.5 1.5 1.5 1 1.4 1.4 1.4 1.4 1 1.6 1.6 1.6 1.6 1 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generatjxon Reproduction Evaluations ) Dupont Haskell Laboratory Study: :em Gavage ml Day 60 Gavage ml Day 61 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176' 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 1.7 1.2 1.6 1.4 1.6 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 1.5 1.3 1.3 1.5 1.4 1.6 1.5 1.5 1.5 1.6 1.4 1.3 1.4 1.4 1.5 1.4 1.3 1.5 1.4 1.4 1.5 1.5 1.7 1.2 1.6 1.4 1.6 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 1.5 1.3 1.3 1.5 1.4 1.6 1.5 1.5 1.5 1.6 1.4 1.3 1.4 1.4 1.5 1.4 1.3 1.5 1.4 1.4 1.5 1.5 Gavage ml Day 62 1.7 1 <>2 1.6 1.4 1.6 1.4 1.5 1.5 1.4 1.3 1.4 1.3 1.1 1.5 1.2 1.3 1.5 , 1.5 1.3 1.3 1.5 1.4 1.6 1.5 1.5 1.5 1.6 1.4 1.3 1.4 1.4 1.5 1.4 1.3 1.5 1.4 1.4 1.5 1.5 Qavage iml Ejay 63 1.8 1.2 1.6 1.4 1.6 1.5 1.6 1.5 1.5 1.3 1.5 1.4 1.1 1.5 1.2 1.3 1.5 1.5 1.4 1.4 1.5 1.4 1.7 1.5 1.5 1.5 1.6 1.4 1.3 1.5 1.4 1.6 1.4 1.4 1.6 1.4 1.4 1.5 1.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml, Day 66 1.8 1.8 1.8 1.2 1.2 1.2 1 . 6 1 . 6 i .6 1.4 1.4 1.4 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.6 1.6 1.5 1.5 i .5 1.5 1.5 1.5 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.1 1.5 1.1 1.5 1.1 1.5 1.2 1.2 1.2 1.3 .3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1 .4 1.5 1.5 1.5 1.4 1.4 1.4 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.4 1.4 1.4 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.6 1.6 1.6 -573- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.8 1.8 1.8 1.8 1.8 1.2 1.2 1.2 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 1.1 1.5 1.1 1.5 1.1 1.5 1.1 1.5 1.1 1.5 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.5 1.5 1.5 1 . 6 1 . 6 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1 . 6 1 . 6 1.5 1.5 1.5 1 . 6 1 - 6 1 . 6 1 . 6 1 . 6 1.7 1.7 1.4 1.4 1.4 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1 . 6 1 . 6 1.6 1.6 1.6 1.6 1.6 ); H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generatjon Reproduction Evaluations .) Dupont Haskell Laboratory Study: fern Gavage ml Day 60 Gavage ml Day 61 Female, II 0 mg/kg 665228 1.7 1.7 665260 1 . 6 1.6 665189 1 . 6 1 . 6 665204 1.4 1.4 665327 1.4 1.4 665203 1 . 2 1 . 2 Gavage ml Day 62 1.7 1.6 1.6 1.4 * 1.4 1.2 Gkvage iml Dky 63 1.6 1.7 1.6 1.4 1.4 1.2 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml ; Day 66 1.6 1.7 1.6 1.4 1.4 1.2 1.6 1.7 1.6 1.4 1.4 1.2 1.6 1.7 1.6 .4 .4 1.2 -574- ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory INDIVIDUAL DOSE VOLUMES Gavage ml Day 60 Gavage ml Day 61 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 , 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 1.6 1.3 1.4 1.3 1.6 1.3 1.6 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.3 1.3 1.8 1.4 1.6 1.6 1.4 1.4 1.6 1.3 1.5 1.7 1.7 1.4 1.1 1.2 1.4 1.4 1.2 1.4 1.6 1.3 1.4 1.3 1.6 1.3 1.6 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.3 1.3 1.8 1.4 1.6 1.6 1.4 1.4 1.6 1.3 1.5 1.7 1.7 1.4 1.1 1.2 1.4 1.4 1.2 1.4 Gavage ml Day 62 1.6 1.3 1.4 1.3 1.6 1.3 1.6 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.3 1.3 1.8 1.4 1.6 1.6 1.4 1.4 1.6 1.3 1.5 1.7 1.7 1.4 1.1 1.2 1.4 1.4 1.2 1.4 Gavage ml Day 63 1.6 1.2 1.4 1.4 1.6 1.4 1.6 1.4 1.4 1.5 1.4 1.5 1.4 1.4 1.5 1.4 1.4 1.8 1.4 1.6 1.6 1.3 1.4 1.6 1.3 1.5 1.7 1.7 1.5 1.2 1.3 1.4 1.4 1.2 1.4 Gavage ml Day 64 1.6 1.2 1.4 1.4 1.6 1.4 1.6 1.4 1.4 1.5 1.4 1.5 1.4 1.4 1.5 1.4 1.4 1.8 1.4 1.6 1.6 1.3 1.4 1.6 1.3 1.5 1.7 1.7 1.5 1.2 1.3 1.4 1.4 1.2 1.4 Gavage ml Day 65 1.6 1.2 1.4 1.4 1.6 1.4 1.6 1.4 1.4 1.5 1.4 1.5 1.4 1.4 1.5 1.4 1.4 1.8 1.4 1.6 1.6 1.3 1.4 1.6 1.3 1.5 1.7 1.7 1.5 1.2 1.3 1.4 1.4 1.2 1.4 Gavage ml Day 66 1.6 1.2 1.4 1.4 1.6 1.4 1.6 1.4 1.4 1.5 1.4 1.5 1.4 1.4 1.5 1.4 1.4 1.8 1.4 1.6 1.6 1.3 .4 1.6 .3 1.5 1.7 1.7 1.5 1.2 1.3 1.4 1.4 1.2 1.4 - 575 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.6 1.6 1.6 1.6 1.6 1 . 2 1 . 2 1 . 2 1.3 1.3 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1 . 6 1 . 6 1.6 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1 . 6 1 . 6 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.8 1.4 1.8 1.4 1.8 1.4 1,8 1.4 1.8 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1 . 2 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.2 1 . 2 1.2 1.3 1.3 1.4 1.4 1.4 1.4 1.4 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study:] :em Gavage ml Day 60 Gavage ml Day 61 Female, VI 100 mg/kg Gavage ml Day 62 Gavage ml Day 63 665295 665251 , 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316' 665173 1.6 1.4 1.5 1.3 1.4 1.5 1.5 1.5 1.4 1.4 1.5 1.5 1.5 1.2 1.4 1.1 1.3 1.5 1.2 1.5 1.5 1.5 1.6 1.7 1.5 1.3 1.6 1.6 1.5 1.3 1.5 1.4 1.5 1.2 1.5 1.6 1.6 1.4 1.4 1.5 1.5 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 . 1'4 1.5 1.5 1.5 1.5 1.5 1.5 1.2 1.4 1.2 1.4 1.1 1.1 1.3 1.3 1.5 1.5 1.2 1.2 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.7 1.7 1.5 1.5 1.3 1.3 1.6 1.6 1.6 1.6 1.5 1.5 1.3 1.3 1.5 1.5 1.4 1.4 1.5 1.5 1.2 1.2 1.5 1.5 1.7 1.4 1.5 1.3 1.5 1.5 1.5 1.5 1.4 1.3 1.6 1.5 1.5 1.3 1.4 1.2 1.3 1.6 1.3 1.6 1.5 1.6 1.5 1.7 1.5 1.4 1.5 1.6 1.5 1.3 1.4 1.4 1.6 1.2 1.5 Key: n m = Not Measurable; partial dose given INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 1.7 1.7 1.7 1.4 1.4- 1.4 1.5 1.5 1.5 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.3 1.3 1.3 1.6 1.6 1.6 1-5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.4 1.4 1.4 1.2 1.2 1.2 1.3 1.3 1.3 1,6 1.6 1.6 1.3 1.3 1.3 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.7 1.7 1.7 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.5 1.6 1.6 1.6 1.5 1.5 1.5 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1 .6 1.2 1.2 1.2 1.5 1.5 1.5 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.5 1.5 1.2 1.2 1.2 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1 . 6 1 . 6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 HU 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1 . 6 1 . 6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1 . 6 1 . 6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5 >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory c, , INDIVIDUAL DOSE VOLUMES Gavage ml Day 60 Gavage ml Day 61 Female, VIII 1000 m g / k g 665234 1.5 1.5 665242 1.4 1.4 665183 1.3 1.3 665261 1.5 1.5 665291 1.5 1.5 665337 1.3 1.3 665333 1.4 1.4 665200 1.5 1.5 665310 1.6 1 . 6 665326 1.2 1.2 665302 1.3 1.3 665179 1.4 1.4 665287 1.3 1.3 665172 1.4 1.4 665194 1.3 1.3 665296 1.0 1.0 665193 1 . 6 1 . 6 665320 1.3 1.3 665315 1.3 1.3 665318 1.6 1 . 6 665279 1 . 6 1 . 6 665224' 1.7 1.7 665254 1.6 1 . 6 665245 1.4 1.4 665322 1.4 1.4 665214 1.4 1.4 665321 1.2 1 . 2 665171 1.4 1.4 665265 1.7 1.7 665169 1.3 1.3 665191 1.4 1-4 665231 1.3 1.3 665288 1.5 1.5 665282 1.5 1.5 665275 1.3 1.3 665229 1.3 1.3 665237 1.2 1.2 665209 1.4 1.4 665335 1.4 1.4 Gavage ml Day 62 1.5 1.4 1.3 1.5 1.5 1.3 1.4 1.5 1.6 1.2 1.3 1.4 1.3 1.4 1.3 1.0 1.6 1.3 1.3 1.6 1.6 1.7 1.6 1.4 1.4 1.4 1.2 1.4 . 1-7 1.3 1.4 1.3 1.5 *1.5 1.3 1.3 1.2 1.4 1.4 Gavage ml Day 63 1.6 1.4 1.3 1.5 1.6 1.3 1.4 1.6 1.6 1.3 1.3 1.5 1.5 1.4 1.3 1.1 1.5 1.2 1.3 1.6 1.7 1.7 1.6 1.4 1.4 1.4 1.2 1.5 1.7 1.3 1.4 1.3 1.5 1.6 1.3 1.4 1.3 1.4 1.4 Gavage ml Day 64 1.6 1.4 1.3 1.5 1.6 1.3 1.4 1.6 1.6 1.3 1.3 1.5 1.5 1.4 1.3 1.1 1.5 1.2 1.3 1.6 1.7 1.7 1.6 1.4 1.4 1.4 1.2 1.5 1.7 1.3 1.4 1.3 1.5 1.6 1.3 1.4 1.3 1.4 1.4 Gavage ml Day 65 1.6 1.4 1-3 1.5 1.6 1-3 1.4 1-6 1.6 1 .3 1.3 1-5 1.5 1 .4 1-3 1.1 1 .5 1.2 1 .3 1.6 1 .7 1 .7 1.6 1.4 1.4 1.4 1.2 1.5 1.7 1.3 1.4 1 .3 1.5 1.6 1.3 1.4 1.3 1 -4 1.4 Gavage ml Day 66 1.6 1.4 1.3 1 .5 1.6 1.3 1.4 1.6 1.6 1 .3 1 .3 :i.5 1 .5 1.4 1 .3 1.1 1.5 1.2 1.3 1.6 1 .7 1.7 1.6 1 .4 1 .4 =1.4 1.2 1 .5 1.7 1.3 1.4 1.3 1.5 1.6 1.3 1.4 1.3 1.4 1.4 -577- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 6 8 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.6 1.6 1.6 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.3 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1 . 6 1.6 1.6 1.5 1.5 1 . 6 1 . 6 1.6 1.7 1.7 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.1 1.5 1.5 1.5 1 . 6 1 . 6 1.2 .1. 2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1 . 8 1 . 8 1.6 1.4 1.6 1.4 1.6 1.4 1.6 1.4 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1 . 2 1 . 2 1 . 2 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1 . 8 1 . 8 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1 . 6 1 . 6 1.6 1.5 1.5 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study:* Ifem Gavage ml Day 60 Gavage ml Day 61 Female, VIII 1 0 0 0 mg/kg 665303 1.3 1.3 665328 1.4 1.4 665299 1.3 1.3 665255 1.5 1.5 665213 1.4 1.4 665280 1.6 1 . 6 - Gavage ml Day 62 1.3 1.4 1.3 1.5 1.4 1.6 Gavage ml Day 63 1.3 1.4 1.4 1.5 1.5 1.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 64 Gavage ml Day 65 Gavage ml Day 66 1.3 1.3 1'.3 1.4 1.4 1.4 1.4 1.4 1.4 T.1.5 1.5 1.5 1.5 1.5 5 1.6 1.6 1.6 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 67 Gavage ml Day 68 Gavage ml Day 69 Gavage ml Day 70 Gavage ml Day 71 1.3 1.3 1.3 1.3 1 1.4 1.4 1.4 1.5 1 1.4 1.4 1.4 1.4 1 1.5 1.5 1.5 1. 6 1 1.5 1.5 1.5 1.5 1 1 . 6 1 . 6 1 . 6 1.7 1 H-25425: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: em Gavage ml Day 72 Gavage ml Day 73 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 . 665232 665307 665246 665289 665264 665185 ' 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 1.8 1.3 1.6 1.4 1.6 1.5 1.6 1.5 1.5 1.4 1.5 1.3 1.1 1.5 1.2 1.4 1.5 1.5 1.4 1.3 1.6 1.4 1.7 1.5 1.6 1.6 1.7 1.5 1.3 1.5 1.4 1.6 1.4 1.4 1.6 1.4 1.5 1.6 1.6 1.8 1.3 1.6 1.4 1.6 1.5 1.6 1.5 1.5 1.4 1.5 1.3 1.1 1.5 1.2 1-6 1-4 1.5 1-6 1-6 Gavage ml Day 74 1.8 1.3 1.6 1.4 1.6 1.5 1.6 1.5 1.5 1.4 1.5 1.3 1.1 1.5 1.2 * 1.6 1.4 1.5 1.6 1.6 Gavage Iml Defy 75 1.8 1.3 1.6 1.4 1.6 1.5 1.6 1.5 1.5 1.4 1.5 1.3 1.1 1.5 1.2 1-6 1.4 1-5 1.6 1.6 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml _ Day 78 1 . 8 1.9 1.9 1.3 1.3 l;,3 1.6 1.7 1,.7 1.4 1.5 li.5 1.6 1.6 T .6 1.5 1.5 1.5 1.6 1.6 lj.6 1.5 1.5 1.5 1-5 1.5 1..5 1.4 1.4 1.4 1.5 1 . 6 1 . 6 1.3 1.4 1.4 1.1 1.1 1.1 1.5 1.5 1.5 1.2 1.2 1.2 1.6 1.5 1.5 1.4 1.5 1.5 1.5 1.5 .5 1.6 1.5 1.5 1.6 1 . 6 1 . 6 -579- Company Sanitized. Does not DuPont-11418 Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.9 1.9 1.9 1.9 1.9 1.3 1.3 1.3 1.3 1.3 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.1 1.1 1.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 1.2 1.2 1.2 1.2 1.2 co a < o 2 c '5 oco 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > Dupont Haskell Laboratory Study: fern Gavage ml Day 72 Gavage ml Day 73 Female, II 0 mg/kg 665228 1.6 1.6 665260 1.6 1.6 665189 1 . 6 1.6 665204 1.4 1.4 665327 1.4 1.4 665203 1.2 Gavage ml Day 74 1.6 1.6 1.6 1.4 1.4 Gavage ml Day 75 1.6 1.6 1.6 1.4 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 73 1 . 6 1.7 1.7 1 . 6 1.7 1.7 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 -580- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Studya :em Gavage ml Day 72 Gavage ml Day 73 Female, IV 10 mg/kg Gavage ml Day 74 Gavage ml Day 75 665308 1.6 1 . 6 1 . 6 1 . 6 665215 1.3 1.3 1.3 1.3 665277 1.5 1.5 1.5 1.5 665241 1.4 1.4 1.4 1.4 665236 1.7 1.7 1.7 1.7 665324 1.4 1.4 1.4 1.4 665332 1.6 1 . 6 1 . 6 1 . 6 665239 1.5 1.5 1.5 1.5 665182 1.5 1.5 1.5 1.5 665268, 1.6 1.6 1.6 1.6 665218 1.5 1.5 1.5 1.5 665309 1.5 1.5 1.5 1.5 665177 1.4 1.4 1.4 1.4 665202 1.5 1.5 1.5 1.5 665235 1.4 1.4 1.4 1.4 665212 1.4 665180 1.4 665292 1.8 665187 1.4 665205 1.6 665263 1.6 665210 1.4 665181 1.4 665248 1.6 665293 1.3 665329 1.5 665290 1.7 665253 1.7 665286 1.5 665281 1.2 665186 1.2 665330 1.4 665294 1.4 665244 1.3 665258 1.4 INDIVIDUAL DOSE VOLUMES: Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 1.6 1.6 1.6 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.7 1.7 1.7 1.4 1.4 1.4 1 . 6 1.7 1.7 1.5 1.4 1.4 1.5 1.5 1.5 1 . 6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.5 1.4 1.3 1.3 -581 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 )' H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Dupont Haskell Laboratory Study: fern Gavage ml Day 72 Gavage ml Day 73 Female, VI 100 mg/kg 665295 1.7 1.7 665251 1.4 1.4 665300 1.5 1.5 665340 1.3 1.3 665259 1.4 1.4 665341 1.5 1.5 665199 1.5 1.5 665238 1.5 1.5 665250 1.4 1.4 665170 1.4 1.4 665313 1.6 1 . 6 665233 1.5 1.5 665216 1.5 1.5 665266 1.3 1.3 665270 1.5 1.5 665338 1.1 665219 1.3 665267 1.6 665325 1.3 665331 1.6 665217 1.6 665227 1.6 665262 1.6 665247 1.7 665243 1.6 665312 1.4 665298 1.6 665207 1.6 665273' 1.5 665274 1.3 665272 1.5 665195 1.4 665314 1.6 665316 1.2 665173 1.5 Gavage ml Day 74 1.7 1.4 1.5 1.3 < 1.4 1.5 1.5 1.5 1.4 1.4 1.6 1.5 1.5 1.3 1.5 - Giavage : ml day.75 1.7 1.4 1.5 1.3 1.4 1.5 1.5 1.5 1.4 1.4 1.6 1.5 1.5 1.3 1.5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml : Day 78 1.7 1.7 1.7 1.4 1.5 1.5 1.5 1 . 6 1.6 1.3 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.5 1.4 1.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 ). ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generatjion Reproduction Evaluations_______ Dupont Haskell Laboratory b -4Study:J ^fem Gavage ml Day 72 Gavage ml Day 73 Female, VIII 1000 mg/kg 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 . 665302 665179 665287 665172 665194 665296665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229 665237 665209 665335 1.5 1.5 1.4 1.5 1.6 1.3 1.4 1.5 1.7 1.3 1.4 1.5 1.4 1.4 1.3 1.1 1.6 1.3 1.4 1.6 1.7 1.8 1.6 1.4 1.4 1.4 1.3 1.5 1.8 1.3 1.4 1.4 1.5 1.5 1.4 1.4 1.3 1.4 1.4 1.5 1.5 1.4 1.5 1.6 1.3 1.4 1.5 1.7 1.3 1.4 1.5 1.4 1.4 1.3 1.5 1.5 1.4 1.4 1.3 1.4 1.4 Gavage ml Day 74 1.5 1.5 1.4 1.5 1.6 1.3 1.4 1.5 1.7 1.3 1.4 1.5 1.4 1.4 1.3 1.5 1.5 1.4 1.4 1.3 1.4 1.4 Ravage ; ml day 75 1.5 1.5 1.4 1.5 1.6 1.3 1.4 1.5 : 1.7 1.3 1.4 1.5 1.4 1.4 1.3 1.5 1.5 1.4 1.4 1.3 1.4 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 1.5 1.5 .5 1.5 1.5 1 .5 1-4 1.4 1.4 1.5 1.6 .6 1 . 6 1 . 6 .6 1.3 1 .4 1.4 1-4 1 .5 .5 1.5 1 .6 1 .6 1-7 1.7 1 .7 1.3 1 .4 1.4 1.4 1.4 1 .4 1.5 1.5 1 .5 1.4 1.5 1 .5 1-4 1.4 1 .4 1.3 1.3 1 .3 1-5 1 .6 ' 1 .6 1.5 1.6 1 .6 1.4 1.4 1 .4 1.4 1.4 1.4 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 -583- Company Sanitized. Does not contain TSCA CBI ) DuPont-11418 Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1 .6 . 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 l'4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: em Gavage ml Day 72 Gavage ml Day 73 Female, VIII 1000 mg/kg 665303 1.3 1.3 665328 1.5 1.5 665299 1.4 1.4 665255 1.6 665213 1.5 665280 1.7 Gavage ml Day 74 1.3 1.5 1.4 Gavage ml Day 75 1.3 1.5 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 76 Gavage ml Day 77 Gavage ml Day 78 1.3 1.4 1.4 1.5 1.5 1.5 1.4 1.4 1.4 -584- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Gavage ml Day 79 Gavage ml Day 80 Gavage ml Day 81 Gavage ml Day 82 Gavage ml Day 83 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont' Haskell Laboratory Study: INDIVIDUAL DOSE VOLUMES Gavage ml Day 84 Gavage ml Day 85 Female, II o mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232' 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 1.3 1.6 1 .5 1.4 1 .6 1 .6 1.9 1.3 1.7 1 .5 1 -6 1.5 1 .6 1-6 1.6 1.4 1.5 1.4 1.1 1 .6 1-3 1.6 1.5 1.4 1.6 1.6 Gavage ml Day 86 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 1.3 1.6 1.5 1.4 1.6 1.6 davage ; ml day 87 Gavage ml Day 88 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 1-3 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 1.3 1.6 1.5 1.4 1.6 1.6 1.6 1.5 1.4 1.6 1.6 Gavage ml Day 89 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 1.3 1.6 1.5 1.4 1.6 1.6 Gavage ml. Day 90 1.9 1.3 1.7 1.5 1.6 1.5 1.6 1.6 1.6 1.4 1.5 1.4 1.1 1.6 .3 1 .6 1 .5 1.4 1.6 1.6 Gavage ml Day 91 Gavage ml Day 92 1.9 1.3 1.7 1.5 1.7 1.6 1.7 1.6 1.6 1.4 1.9 1.3 1.7 1.5 1.7 1.6 1.7 1.6 1.6 1.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI > :) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______ Dupont Haskell Laboratory Study: :em Gavage ml Day 84 Gavage ml Day 85 Female, II 0 mg/kg 665228 1.7 1.7 665260 1.7 1.7 665189 1.6 1 . 6 665204 1.5 1.5 665327 1.5 1.5 665203 Gavage ml Day 86 1.7 1.7 1.6 1.5 1.5 Cjavage ; ml Day 87 1.7 1.7 1.6 1.5 1-5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml: Day 90 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 -586- Gavage ml Day 91 Gavage ml Day 92 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genera(ion Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 84 Gavage ml Day 85 Female, IV 10 mg/kg 665308 1.6 1.6 665215 1.3 1.3 665277 1.5 1.5 665241 1.4 1.4 665236 1.8 1 . 8 665324 1.5 1.5 665332 1.6 1.6 665239 1.5 1.5 665182 1.5 1.5 665268 1.6 1 . 6 665218 1.6 1.6 665309 1.6 1.6 665177 1.4 1.4 665202 1.5 1.5 665235 1.5 1.5 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 Gavage ml Day 86 1.6 1.3 1.5 ' 1.4 1.8 1.5 1.6 1.5 1.5 1.6 1.6 1.6 1.4 1.5 1.5 Gavage ml Day 87 1.6 1.3 1.5 1.4 1.8 1.5 1.6 1.5 1.5 1.6 1.6 1.6 1.4 1.5 1.5 INDIVIDUAL DOSE VOLUMES: Gavage ml Day 88 Gavage ml Day 89 Gavage ml; Day 90 1.6 1.3 1.5 1.4 1.8 1.5 1.6 1.5 1.5 1.6 1-6 1.6 1.4 1.5 1.5 1.6 1.3 1.5 1.4 1.8 1.5 1.6 1 .5 1.5 1.6 1 .6 1.6 1.4 1.5 1.5 1.6 1.3 1 .5 1.4 .8 1 .5 1.6 1 .5 1.5 1.6 1 .6 1 .6 1.4 1 .5 1.5 -587- Gavage ml Day 91 Gavage ml Day 92 1.6 1.3 1.5 1.4 1.8 1.5 1.7 1.5 1.5 1.6 1.6 1.3 1.5 1.4 1.8 1.5 1.7 1.5 1.5 1.6 . DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study [fern Gavage ml Day 84 Gavage ml Day 85 Female, VI 100 mg/kg 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 66527 665338 1.7 1.5 1 .6 1.4 1 .5 1.6 1 .5 1 .6 1.4 1.4 1.7 1.6 1 .5 1.4 1 .5 1.7 1.5 1.6 1.4 1.5 1.6 1.5 1.6 1.4 1.4 1.7 1.6 1.5 1.4 1.5 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 Gavage ml Day 86 1.7 1.5 1.6 1.4 1.5 1.6 1.5 1.6 1.4 1.4 1.7 1.6 1.5 1.4 1.5 Gavage ml Day 87 1.7 1.5 1.6 1.4 1.5 1.6 1.5 1.6 1.4 1.4 1.7 1.6 1.5 1.4 1.5 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 1.7 1.7 1.7 1.5 1.5 1.5 1.6 1.6 1.6 1.4 1.4 1.4 1.5 1.5 1.5 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.6 1.6 1.6 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.5 Gavage ml Day 91 Gavage ml Day 92 1.7 1.7 1.5 1.5 1.6 1.6 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.5 1.5 1.4 1.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluation Dupont Haskell Laboratory Study :l :em Gavage ml Day 84 Gavage ml Day 85 Female, VIII 1000 mg/kg 665234 665242' 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288. 665282 665275 665229 665237 665209 665335 1.6 1.5 1.4 1.6 1 .6 1.4 1.5 1.6 1.7 1.3 1.5 1.5 1.5 1 .5 1.3 1.6 1.5 1.4 1.6 1.6 1.4 1.5 1.6 1.7 1.3 1.5 1.5 1.5 1.5 1.3 1.6 1 .61.4 1.4 1.3 1.5 1 .4 1.6 1.6 1.4 1.4 1.3 1.5 1.4 Gavage ml Day 86 1.6 1.5 1.4 1.6 1.6 1.4 1.5 1.6 1.7 ` 1.3 1.5 1.5 1.5 1.5 1.3 1.6 1.6 1.4 1.4 1.3 1.5 1.4 Gjavage !ml Djay 87 1.6 1.5 1.4 1.6 1.6 1.4 1.5 1.6 1.7 1.3 1.5 1.5 1.5 1.5 1.3 1.6 1.6 1.4 1.4 1.3 1.5 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml Day 90 1.6 1.6 1.6 1.5 1.5 1 .5 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.5 1.5 1.5 1 . 6 1 . 6 .6 1.7 1.7 1.7 1.3 1.3 1.3 1.5 1.5 1.5 1-5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.6 1.6 1.4 1.4 1.3 1.5 1.4 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.3 1.3 1.5 1.5 1.4 1.4 -589- Gavage ml Day 91 Gavage ml Day 92 1.6 1.5 1.4 1.6 1.7 1.4 1.5 1.6 1.7 1.4 1.6 1.5 1.4 1.6 1.7 1.4 1.5 1.6 1.7 1.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Dupont Haskell Laboratory Study: :em Gavage ml Day 84 Gavage ml Day 85 Female, VIII 1000 mg/kg 665303 1.4 1.4 665328 1.5 1.5 665299 1.4 1.4 665255 665213 665280 Gavage ml Day 86 1.4 1.5 1.4 Gavage ; ml bay 87 1.4 1.5 1.4 INDIVIDUAL DOSE VOLUMES Gavage ml Day 88 Gavage ml Day 89 Gavage ml' Day 90 1.4 1.4 1.4 1.5 1.5 1.5 1.4 1.4 1.4 - 590- Gavage ml Day 91 Gavage ml Day 92 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 180 V0S1 uiBiuoo }ou saoQ paz^jueQ AueduioQ H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __________________ DuPont-11418 APPENDIX C INDIVIDUAL BODY WEIGHTS A -591- 180 V0S1 uiejuoo ?ou saoa -pazinueg Auedwoo H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________ DuPont-11418 INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES Critical Dates Day 72 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights and clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section; Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and three-month recovery periods. Day 91 Last day of body weight and food consumption data collection for male and female rats designated for the subchronic toxicity evaluation. Last day of test substance administration for male rats designated for the subchronic toxicity evaluation. Day 92 Male rats designated for the subchronic toxicity evaluation were sacrificed. Last day of test substance administration for female rats designated for the subehronic toxicity evaluation. Day 93 Female rats designated for the subchronic toxicity evaluation were sacrificed. Day 126 Last day of body weight and food consumption data collection for rats designated for the one-month recovery period. Last day of food consumption data collection for rats designated for the three-month recovery period. Day 127 Male and female rats designated for the one-month recovery were sacrificed. Day 182 Male and female rats designated for blood fluorine level evaluation were sacrificed. Abbreviations mg/kg = mg/kg/day Note Absence of data indicates the animal was not alive at the time of data collection. -592- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: le gBody Weight Day 0 Male, I 0 mg/kg gBody Weight Day 7 Body Weight g Day' 14 Individual Body Weights Body Weight Body Weight g Day 21 g Day 28 ` 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 6.65149 665081 239.6 238.3 280.2 246.3 224.9 240.0 253.7 256.5 250.3 209.5 241.0 244.3 232.9 264.6 236.4 246.5 244.0 242.0 208.2 237.2 229.3 233.0 240.8 223.4 238.3 234.3 238.5 262.5 225.2 221.1 243.1 250.5 244.2 213.2 249.3 222.9 241.7 247.2 237.9 290.5 293.4 352.9 305.5 270.7 305.7 314.5 317.7 292.8 260.4 308.3 289.4 281.2 308.8 301.4 306.0 291.9 286.4 251.1 . 284.7 295.1 279.1 307.1 270.0 297.7 290.5 297.3 328.5 ^ 280.6 269.4 296.4 315.5 298.1 263.1 312.1 274.3 292.6 311.6 291.0 331.3 339.5 4(05.6 371.9 3B1.1 372.0 366.6 3(70.5 3j31.2 306.5 3jS4.6 344.5 3)32.8 351.4 347.1 358.9 3p.5 3^7.4 292.3 339.0 3 4 6 .I 329.1 363.4 30.2 30.6 30.0 39.9 385.5 328.2 30.7 345.0 3^9.6 333.8 305.2 3 6 .0 35.1 34.2 368.4 330.3 371.1 371.7 443.0 424.4 365.0 412.5 416.4 429.2 358.2 351.5 410.2 390.1 378.4 398.2 407.0 410.8 370.5 363.8 331.8 385.9 404.5 369.2 418.5 342.8 392.1 363.8 380.3 441.7 371.6 348.1 389.4 408.5 368.6 343.9 415.8 349.6 372.4 416.2 368.2 399.5 410.4 487.0 464.8 396.1 458.6 449.7 478.3 390.6 383.3 445.3 428.0 416.1 427.1 443.5 445.5 399.0 391.7 360.4 422.0 442.9 390.5 461.4 370.2 425.2 391.3 415.8 473.4 412.5 378.9 410.6 432.5 399.6 377.4 461.8 370.8 399.3 448.6 394.8 DuPont-11418 Company Sanitized. Does not contain TSCA CBI g g g gBody Weight Body Weight Body Weight Body Weight Day 35 Day 42 Day 49 Day 56 426.4 432.5 537.9 494.4 423.4 488.9 472.7 508.3 417.0 416.2 485.4 466.7 448.4 446.3 476.6 462.8 431.1 421.3 391.1 455.5 479.3 418.5 498.6 392.0 454.4 407.9 435.4 501.3 436.1 400.3 432.8 455.5 425.1 406.6 496.7 392.7 416.9 480.1 415.0 452.8 456.6 561.7 510.5 435.2 500.2 476.1 525.1 437.1 426.5 498.4 488.9 476.1 458.2 501.0 491.0 465.5 442.5 414.1 467.8 518.5 427.6 525.7 415.8 487.0 428.1 461.8 523 JO 463.7 420.3 448.6 472.5 442.4 425.4 520.7 417.0 432.8 504.1 433.8 471.2 474.7 587.7 547.4 463.2 527.3 500.3 556.1 463.3 449.3 514.6 507.7 498.5 484.1 532.8 514.6 488.4 453.5 431.5 498.4 549.1 450.4 563.7 432.9 499.6 446.6 485.4 550.1 482.8 436.1 464.8 492.3 459.3 435.3 547.6 431.9 447.8 527.2 451.1 486.1 494.8 615.9 563.0 489.2 564.0 515.7 578.7 487.6 458.9 532.9 533.9 522.9 501.3 550.1 533.5 506.4 479.8 453.7 531.7 574.0 474.5 589.7 451.5 524.7 464.4 498.9 577.6 503.2 455.9 478.4 513.7 472.5 451.6 572.5 439.5 466.9 546.3 472.8 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generajtion Reproduction Evaluations Study: rale DuPont-11418 Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body weight Body Weight Body Weight Body Weight Body Weight g g g g g g g g Day 0 Day 7 Day i14 Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 Male, I 0 mg/kg 665159' 665043 665064 665121 665106 665008 243.9 240.6 232.5 234.1 259.0 263.8 303.5 297.5 285.3 281.5 316.6 315.4 3S0.8 349.1 331.8 354.2 30.2 364.9 395.1 395.8 380.0 368.3 407.2 414.7 435.8 435.0 415.9 408.2 443.7 451.0 460.6 461.9 435.2 433.0 472.6 468.4 485.5 491.1 445.7 461.8 496.7 491.6 500.5 513.2 463.9 487.4 533.5 525.5 522.9 530.2 465.1 499.1 541.2 539.8 - 594- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: male Individual Body Weights Body Weight Day 0 Male, III 10 mg/kg g *Body Weight Day 7 gBody Weight Day 14 gBody Weight Day 21 gBody Weight Day 28 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 247.8 254.2 263.4 240.7 226.1 221.7 246.7 254.2 252.2 223.3 227.6 239.1 228.2 249.8 217.6 240.8 243.6 241.9 217.4 243.3 233.1 234.6 243.4 225.2 242.7 235.2 229.7 257.6 242.1 218.9 237.6 253.2 244.9 215.0 247.2 305.6 313.9 318.4 301.8 279.5 271.7 304.5 300.5 312.7 271.6 262.0 300.6 277.7 294.2 251.6 297.8 296.4 291.5 273.7 288.9 280.7 292.9 293.7 266.7 298.2 281.2 275.4 307.6 ` 304.4 261.0 290.6 310.1 300.0 268.1 294.2 349.2 364.5 362.2 355.7 316.2 317.2 351.0 348.8 366.0 313.1 279.5 342.4 313.3 337.7 286.8 336.0 339.9 330.0 315.3 321.2 312.5 329.0 330.0 303.3 342.5 327.1 307.6 353.8 360.8 293.4 331.2 355.4 348.0 299.7 338.3 396.1 411.5 413.9 400.1 354.0 361.5 395.2 390.5 414.2 358.0 302.2 386.2 348.6 383.0 321.2 381.4 381.5 368.0 361.8 349.2 343.3 366.8 380.7 340.9 384.5 366.3 345.5 396.9 413.3 327.4 366.2 392.3 391.6 334.1 380.0 439.8 457.6 461.3 430.0 374.7 396.6 438.1 425.6 451.8 389.8 333.4 424.6 381.7 406.6 356.2 419.8 417.0 396.7 396.2 379.0 372.3 402.8 411.9 379.5 430.5 401.3 375.9 442.0 462.1 358.8 398.3 432.9 424.6 371.6 421.0 - 595- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Body Weight Body Weight Body Weight Body Weight g gg g Day 35 Day 42 Day 49 Day 56 466.7 483.8 487.7 468.0 392.2 423.6 462.6 443.3 476.5 411.0 347.8 446.5 398.4 422.3 372.0 442.7 444.0 421.7 423.7 408.1 399.0 422.6 435.8 399.4 450.1 417.9 386.2 466.7 491.4 384.8 428.6 459.9 448.0 395.8 447.4 487.1 507.3 518.6 482.0 417.3 441.7 473.7 450.7 506.8 422.3 365.0 468.6 421.7 449.1 398.8 453.6 470.7 439.1 457.5 439.8 431.7 448.2 455.5 412.7 467.9 438.9 406.0 494.5 508.2 410.5 445-1 481.4 479.0 409.7 467.7 519.3 536.0 560.5 504.2 438.7 461.5 502.5 472.5 531.6 446.9 377.9 495.3 438.3 472.9 430.9 477.6 500.1 461.4 489.2 461.4 449.2 457.9 482.7 436.5 499.3 471.8 424.2 521.1 545.4 422.8 466.6 504.1 501.9 438.1 486.6 534.9 561.8 525.6 525.0 444.3 481.6 523.5 476.0 551.4 465.6 385.9 513.2 454.2 483.0 455.0 494.3 517.4 478.6 511.0 481.9 463.6 474.4 492.4 447.6 521.1 487.3 442.1 537.4 558.8 436.1 481.8 521.8 521.0 449.1 514.6 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: lale Individual Body Weights g g gBody Weight Body Weight Body Weight Body Weight Body Weight g Day 0 Day 7 Day 14 Day 21 g Day 28 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103' 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 246.6 244.7 275.5 243.9 225.9 225.0 244.8 257.4 239.2 215.4 234.7 246.1 239.5 252.7 243.6 229.8 246.4 239.7 221.8 241.4 240.2 227.6 253.3 226.0 233.7 231.7 233.4 253.0 233.4 229.0 238.5 263.6 252.2 214.1 242.2 303.2 308.0 346.0 292.9 271.4 280.0 298.4 326.3 286.6 258.7 285.5 305.6 298.3 320.2 309.4 * 278.0 309.2 299.3 281.0 296.0 298.4 281.4 319.1 270.2 293.5 288.4 295.6 302.4 298.1 283.8 278.7 317.3 314.8 255.9 296.0 34Q.7 359.4 395.2 329.8 300.7 325.9 340.0 373.5 326.2 290.4 320.1 341.8 355.2 361.4 366.6 311.0 342.8 332.6 323.2 327.9 343.4 313.8 369.2 308.5 336.6 326.8 330.7 342.4 331.6 330.9 313.5 353.0 361.5 283.5 335.4 389.7 404.0 456.3 370.1 335.2 369.5 382.6 416.4 367.7 322.9 356.9 375.4 393.9 405.6 425.8 338.2 396.6 365.2 364.2 357.6 381.9 348.4 420.9 342.5 378.1 367.3 372.4 383.4 371.3 371.4 351.8 397.3 412.7 319.7 386.5 441.2 443.3 507.2 417.5 373.6 ,, 399.3 423.1 451.4 410.8 351.6 384.0 401.3 435.5 435.3 461.3 366.9 436.2 398.1 398.5 391.5 422.6 374.5 467.8 372.2 408.6 400.3 408.3 419.0 401.0 409.2 385.0 419.4 448.3 348.8 415.4 DuPont-11418 Company Sanitized. Does not contain TSCA CBI g g g gBody Weight Body Weight Body Weight Body Weight Day 35 Day 42 Day 49 Day 56 478.8 481.7 540.4 450.6 399.9 435.9 451.8 489.8 443.2 375.9 414.5 436.6 469.7 467.1 523.0 398.7 469.7 422.3 429.5 419.8 455.3 396.2 498.4 389.2 439.5 431.2 433.3 447.3 435.7 438.4 405.2 445.6 478.1 370.0 437.8 491.2 489.0 557.2 473.4 415.6 444.7 462.7 501.0 452.0 385.3 440.9 448.1 491.7 484.9 552.5 419.3 486.7 436.3 440.9 427.7 478.3 416.1 521.0 411.0 467.0 454.0 452.4 469.2 455.4 458.2 425.0 475.8 505.4 386.0 458.7 518.1 504.9 582.4 504.7 434.1 443.0 488.9 518.3 470.3 401.5 448.0 477.9 517.6 504.5 580.1 441.6 514.9 453.2 460.8 445.1 494.1 432.0 545.4 427.0 494.7 475.7 471.3 488.9 478.4 473.1 451.5 498.1 520.3 402.1 470.7 538.4 531.0 596.1 528.3 456.5 477.1 513.3 540.5 501.5 411.2 470.9 496.1 546.1 525.1 605.3 454.3 529.1 464.9 466.4 458.8 508.6 437.9 561.2 435.5 520.4 495.0 484.0 493.5 485.6 485.2 468.7 505.2 537.9 422.7 488.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study : lale Individual Body Weights: Body Weight Body Weight Body Weight Body Weight Body Weight g g gg P Day 0 Day 7 Day 14 Day 21 Day 28 Male, VII 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059, 665123' 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 665095 259.3 242.5 255.2 246.9 237.4 228.5 244.8 250.5 254.7 230.1 227.1 246.5 228.5 262.4 226.3 239.8 240.7 235.4 214.5 240.1 226.2 233.8 254.3 225.4 243.8 246.9 245.2 251.6 235.7 229.0 250.3 258.3 253.6 211.9 249.7 220.9 252.8 238.3 240.6 322.9 300.4 ` * 305.6 299.1 287.0 272.1 287.0 304.6 307.5 283.6 269.5 291.8 270.8 308.8 275.3 290.2 291.3 280.0 256.5 283.3 283.9 279.4 305.5 266.2 301.0 297.7 302.5 307.9 298.2 265.7 303.0 303.2 302.1 . 256.2 302.8 271.3 307.2 287.9 283.6 369.0 343.4 354.9 349.8 335.9 308.3 331.2 3^3.6 3160.2 326.8 304.3 330.8 3|D5.3 352.3 37.9 336.5 331-5 309.9 295.3 34.2 3^4.2 327.0 349.7 302.3 3ji0.5 353.2 351.0 32.8 347.1 310.9 3^3.7 351.9 355.6 2|3.6 345.3 309.0 31.8 339.1 322.6 415.5 387.9 392.1 393.9 391.3 349.3 384.3 387.4 411.4 373.5 340.0 379.2 350.3 403.9 345.8 387.3 377.2 331.5 330.2 354.0 364.7 386.7 388.8 340.2 375.6 399.7 390.6 401.4 392.3 355.7 389.1 401.6 397.7 334.4 384.7 358.7 396.0 384.2 359.2 460.1 421.6 416.1 430.6 430.6 371.4 412.3 416.5 444.0 405.3 359.8 409.5 376.6 432.7 370.1 421.5 398.6 348.0 364.1 380.2 394.2 417.6 408.7 362.2 408.3 441.0 422.9 437.7 426.9 381.1 416.0 439.8 419.3 361.4 412.1 388.6 426.9 407.6 388.7 - 597- DuPont-11418 Company Sanitized. Does not contain TSCA CBI g g g gBody Weight Body Weight Body Weight Body Weight Day 35 Day 42 Day 49 Day 56 485.8 456.7 446.1 458.3 460.5 399.4 449.9 439.0 475.5 429.3 389.2 452.4 398.4 451.1 397.7 450.8 425.9 365.1 391.8 406.6 419.7 440.7 435.3 382.7 431.6 468.7 456.1 476.9 457.5 401.9 447.8 473.7 446.7 394.8 445.9 414.6 453.6 442.0 416.'6 498.9 478.3 461 ;3 469.1 482.8 409.3 463.4 458.3 502.0 438:6 409.2 482.3 422.4 475.0 421.0 484.3 438.0 388.4 416.3 434.5 447.8 466.1 451.6 396.5 450.9 489.6 483.4 500.9 471.3 427.0 477.5 503.3 476.3 413.0 456.1 432.0 490.7 459.0 432.8 519.4 502.7 482.1 501.4 511.9 438.3 499.2 475.4 525.8 467.2 430.8 512.5 444.1 493.1 447.8 516.9 457.8 399.6 446.0 457.0 468.8 500.4 477.5 418.7 465.0 514.1 508.6 535.8 495.3 452.1 516.7 540.5 511.3 431.4 477.1 443.9 526.6 481.4 436.6 531.1 522.3 496.8 519.7 531.5 457.3 514.4 489.0 544.1 485.3 434.2 525.5 456.8 492.0 454.0 536.0 466.0 402.3 455.5 470.0 486.7 501.2 490.1 430.2 479.2 528.3 528.5 551.3 511.0 467:7 539.5 552.7 524.6 448.4 498.1 451.2 541.4 494.1 456.3 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: lale DuPont-11418 Company Sanitized. Does not contain TSCA CBI Body Weight Body Weight g Day 0 g Day 7 Male, VII 1000 mg/kg gBody Weight Day 14 Individual Body Weights' g g gBody Weight Body Weight 'Body Weight Day 21 Day 28 Day 35 gBody Weight Day 42 Body Weight g Day 49 gBody Weight Day 56 665031 665146 665062 665138 66512 665007 245.9 245.3 239.6 218.6 260.2 267.1 301.2 303.4 293.3 266.8 306.6 320.9 349.3 349.4 345.9 300.2 350.6 354.6 394.1 398.6 390.9 339.6 390.1 409.1 427.0 421.1 417.3 366.6 412.5 443.7 450.8 449.4 450.8 395.8 436.7 462.3 470.8 471.8 481.4 415.0 457.6 490.0 500.3 502.2 515.4 434.5 471.5 520.1 510.8 516.6 532.4 445.0 488.4 538.3 H-25425: Subchronic Toxicity i 9-Day Gavage Study in Rats with One-Generajtion Reproduction Evaluations Study Body Weight S Day 63 Male, I 0 mg/kg 665047 665049 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046' 665021 665087 665079 665042 665098 665149 665081 505.8 521.8 651.4 577.1 505.7 602.1 539.4 595.3 511.0 486.8 553.2 550.4 533.6 515.0 570.7 557.6 532.1 501.8 469.5 540.6 592.8 489.6 605.8 462.5 540.2 482.7 516.8 583.8 516.8 465.7 503.0 519.1 488.3 466.5 599.6 453.1 471.3 556.3 479.7 517.1 537.4 662.9 600.4 516.7 615.9 569.9 614.6 ` 527.2 497.5 575.9 566.9 552.4 517.0 585.6 571.4 545.7 519.5 481.9 559.4 626.3 499.7 623.8 474.7 554.6 494.5 533.4 595.9 524.9 482.7 504.0 534.2 503.4 494.3 621.3 460.1 484.2 573.3 493.1 Individual Body Weights gBody Weight Body Weight 3 Day 84 Day 91 535.1 5^2.3 686.6 64.1 58.1 627.1 5f5.4 633.6 541.5 497.3 590.8 5$5.9 548.2 530.1 598.7 546.7 557.2 703.1 615.1 526.5 647.5 600.8 644.5 555.3 504.9 593.3 591.9 568.3 536.5 610.0 553.2 569.8 725.1 628.0 531.8 653.3 605.1 655.6 565.3 513.7 590.5 599.8 582.5 542.7 609.5 465.5 493.1 589.3 5b3.6 471.1 501.7 590.5 508.5 473.8 505.7 590.6 503.2 - 599- Company Sanitized. Does not contain TSCA CBI DuPont-11418 Body Weight Body Weight Body Weight Body Weight gggg Day 98 Day 105 Day 112 Day 119 602.9 610.9 603.2 545.8 616.3 603.3 628.7 618.3 556.9 623.1 613.7 633.4 628.3 561.9 626.5 618.0 656.8 632.9 578.0 647.7 484.5 520.2 610.6 516.7 496.8 527.7 616.5 531.0 498.1 526.5 630.8 543.3 513.7 545.2 648.3 553.7 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study Jmale ) DuPont-11418 Body Weight g Day 63 Male, I 0 mg/kg Body Weight g Day 70 Body Weight Day! 77 Individual Body Weights gBody Weight Body Weight Body Weight 99 Day 84 Day 91 Day 98 gBody Weight Day 105 gBody Weight Day 112 gBody Weight Day 119 665159 665043 665064 665121 665106 665008 542.6 544.5 474.5 519.4 564.0 563.8 545.6 567.4 482.1 537.9 581.3 575.4 553.3 577.1 4{37.1 5j56.2 603.8 592.3 569.0 593.3 495.7 569.1 614.4 597.2 571.5 589.7 501.5 582.7 623.2 604.3 571.6 597.5 514.2 594.6 637.1 617.5 589.4 594.4 533.2 610.3 647.2 641.0 600.1 613.8 529.8 619.8 656.2 634.1 614.7 632.7 552.0 633.8 672.9 649.8 -600- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: .le Individual Body Weights Body Weight 3 Day 63 Male, III 10 mg/kg gBody Weight Day 70 Body Weight P Day] 77 gBody Weight Day 84 gBody Weight Day 91 665053 665074 665128 665080 664993 665131 665060 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 557.5 572.3 591.7 543.0 465.2 497.5 543.8 490.1 567.2 485.8 395.7 533.4 464.8 492.1 476.9 509.2 538.9 495.4 532.7 498.9 477.3 486.5 513.6 458.4 529.4 498.6 458.8 562.2 575.6 456.3 499.1 540.4 538.9 467.0 522.2 587.1 590.1 620.7 564.8 478.3 512.6 558.0 509.4 581.3 500.9 406.7 552.2 484.0 512.3 497.5 525.8 554.0 515.8 547.6 520.0 491.5 495.1 521.3 478.8 547.4 512.5 464.4 577.9 594.0 474.9 505.3 549.3 558.7 480.6 541.3 5197,3 6|09.0 634.5 5(06.6 490.5 14.4 76.3 517.7 593.1 512.8 409.2 ^65.4 492.4 522.1 538.9 609.3 624.0 651.7 549.3 502.6 528.0 591.4 527.6 602.7 523.4 412.6 575.3 497.5 522.0 521.3 623.4 631.7 642.0 555.2 510.8 529.0 606.1 534.2 608.9 531.9 425.4 585.9 474.5 522.7 525.0 - 601- Company Sanitized. Does not contain TSCA CBI DuPont-11418 Body Weight Body Weight Body Weight Body Weight g g ger ' 98 Day 105 Day 112 Day 119 428.7 596.8 477.0 523.6 537.3 435.7 598.2 501.7 537.2 545.0 435.4 603.4 517.1 541.2 553.1 442.5 621.8 520.5 551.4 569.5 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations stud^ :V ^ H B H K r n a l e ) DuPont-11418 Body Weight a Day 63 Male, v 1 0 0 mg/kg gBody Weight Day 70 gBody Weight Day 77 Individual Body Weights gBody Weight Body Weight Body Weight gg Day 84 Day 91 Day 98 Body Weight g Day 105 gBody Weight Day 112 gBody Weight Day 119 665122 665155 .665073 665089 665119 665137 665103 665143 665054' 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 556.2 544.1 619.4 553.8 472.3 499.2 533.7 566.4 521.4 422.8 492.1 512.7 569.3 547.6 639.6 474.4 538.4 477.4 482.1 471.2 524.9 428.9 576.2 442.6 541.8 512.5 495.6 523.5 498.8 498.0 481.1 520.9 554.6 443.2 508.6 580.4 566.8 632.0 575.2 481.1 513.6 546.7 582.9 547.6 434.1 505.2 523.5 585.3 561.1 664.9 Ana a 556.2 ' 479.5 485.1 418.2 547.8 452.1 593.8 456.0 550.8 530.7 509.6 535.5 505.5 503.0 491.5 521.9 564.7 452.4 513.6 587.5 578.4 642.5 577.6 496.4 496.1 553.8 588.3 555.3 441.6 513.5 533.4 598.5 564.6 672.9 598.3 591.8 648.3 591.4 509.4 512.6 581.7 595.0 562.6 447.5 524.9 548.2 602.0 584.1 689.8 602.6 593.1 653.0 585.8 515.4 512.3 582.4 599.2 570.0 452.3 525.6 552.0 620.5 596.9 709.4 534.8 556.7 613.6 582.9 723.2 543.2 572.1 619.3 593.1 737.9 542.0 574.3 606.9 746.1 557.1 591.6 620.6 775.6 602 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: male ) gBody Weight Day 63 Male, VII 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 665026 665162 665027 665084 665142 665118 665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 665095 547.1 542.9 515.6 552.9 562.8 469.2 531.4 509.6 568.4 499.0 448.7 544.6 474.5 505.3 465.4 557.0 477.3 415.8 471.1 482.4 501.9 521.9 513.1 441.6 477.6 545.0 540.9 567.5 534.5 486.6 555.9 568.4 549.6 460.4 518.7 459.0 560.3 513.1 469.6 Individual Body Weights g g g gWeight Body Weight Body Weight Body Weight Day 70 Day 77 Day 84 Day 91 567.4 559.0 525.7 553.0 574.1 485.9 547.8 521.1 591.7 507.6 463.3 562.4 494.2 524.2 480.4 578.3 487.8 425.4 486.0 499.5 515.0 540.4 506.4 445.9 499.5 566.2 558.7 589.8 553.2 499.7 574.6 588.7 568.5 476.4 525.4 465.9' 575.0 529.1 486.0 575.8 565.2 528.8 564.0 578.9 484.1 551.8 527.9 608.3 518.5 473.5 568.4 493.9 524.9 482.0 476.2 589.1 545.5 491.0 582.9 586.1 540.8 579.3 602.3 493.0 560.6 542.1 624.8 535.0 490.8 578.9 509.0 548.6 492.5 479.5 603.9 549.1 500.1 595.9 597.7 553.3 597.5 619.2 499.6 564.2 558.2 638.6 547.5 485.0 569.8 508.9 554.8 498.8 494.3 612.1 556.2 506.6 -603 Company Sanitized. Does not contain TSCA CBI DuPont-11418 g g g gBody Weight Body Weight Body Weight Body Weight Day 98 Day 105 ' 112 Day 119 482.5 579.7 511.0 554.4 499.3 481.4 588.4 530.7 571.6 502.1 487.4 585.1 534.4 572.5 501.4 503.9 600.3 545.1 591.4 510.2 496.7 615.0 570.1 519.8 514.2 625.1 591.1 534.2 517.1 631.5 592.3 541.3 523.3 644.1 608.3 553.8 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 Study lale Individual Body Weights g g 0 a g g g g gBody Weight Body Weight Body height Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Day 63 Day 70 Dayj 77 Day 84 Day 91 Day 98 Day 105 Day 112 Day 119 Male, VII 1000 mg/kg 665031 665146 665062 665138 665112 665007 522.6 531.8 551.2 452.5 506.9 564.6 542.8 551.4 568.8 461.9 528.5 582.5 5^3.8 5158.9 5)32.1 471.4 5127.6 593.4 561.1 576.5 606.7 464.3 530.2 604.5 567.1 578.4 615.8 486.1 540.4 628.0 580.6 593.3 636.6 497.5 554.5 636.3 597.5 601.9 641.3 511.0 571.0 645.7 598.7 605.9 642.5 507.5. 565.6 648.1 621.4 619.1 665.1 523.6 583.5 655.7 - 604- Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________ _____________________DuPont-11418 Study : H n a l e Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g g g g g g g gg Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Male, I 0 mg/kg 665047 665049' 665070 665130 665076 665015 665068 665148 665016 665086 665023 665072 665151 665164 665154 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 665042 665098 665149 665081 615.5 659.9 621.9 581.0 644.2 514.1 543.9 642.9 550.1 633.0 686.9 634.2 593.6 649.1 631.3 701.4 639.6 596.3 650.1 632.1 705.5 646.9 603.8 657.8 637.6 723.4 653.7 605.8 670.5 642.9 736.2 673.3 618.0 681.1 651.6 745.4 671.7 610.5 681.9 663.9 756.7 685-4 619-0 700.1 667.1 766.2 687.8 628.7 708.1 - 605- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generfoion Reproduction Evaluations Study: lale DuPont-11418 Individual Body. Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g g g g g g g gF Day 126 Day 133 Day, 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Male, I 0 mg/kg 665159 665043 665064 665121 665106 665008 609.9 632.6 547.9 626.2 676.4 650.0 -606 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________________DuPont-11418 Study; lale Individual Body Weights Body Weight Body Weight -Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight gg g g g g g gg Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 >-Day 168 Day 175 Day 182 Male, III 10 mg/kg 665053 665074 665128 665080 664993 665131 665060, 664995 665136 665033 665132 665156 665061 665145 665019 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 439.7 628.0 530.5 546.6 569.5 451.1 649.9 540.4 577.1 595.6 . 452.1 661.2 543.8 586.5 597.2 456.9 669.5 544.2 594.7 593.3 460.7 680.0 545.1 593.7 600.8 469.8 691.1 544.3 610.5 610.0 465.3 695,4 547.5 609.8 617.3 471.3 709.6 551.8 625.5 627.4 470.9 716.9 562.5 634.0 643.3 - 607- Company Sanitized. Does not contain TSCA CB1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________ ______________ ____________________________ DuPont-11418 Study: ale Individual Body Weights g g g g g g g g gBody Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Male, V 100 mg/kg 665122 665155 665073 665089 665119 665137 665103 665143 665054 665035 665048 665030 665028 665052 665150 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 558.5 593.0 624.3 782.4 585.8 614.2 643.6 809.2 593.0 617.3 645.6 834.7 595.9 625.2 643.8 840.9 603.5 633.8 650.2 847.4 607.7 639.7 671.2 868.2 611.5 646.5 668.0 865.5 618.1 ' 668.2 686.8 881.4 625.9 678.5 696.2 894.5 -608 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 Study: .le Individual Body Weights Body Weight.. Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g g g g g9 9 gg Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Male, VII 1000 mg/kg 665160 665096 665082 665107 665152 665120 664999 . 665026 665162 665027 665084 665142 665118665108 665024 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 665158 665002 665067 665095 502.4 604.7 539.4 597.0 506.1 527.9 650.8 613.7 543.5 522.2 622.7 564.0 607.6 523.6 526.9 640.8 579.5 610.2 533.5 525.3 650.4 590.2 608.1 535.5 535.6 662.0 597.0 608.8 545.8 550.8 681.3 605.4 620.0 556.6 548.1 688.0 606.4 626.3 551.9 561.5 707.5 621.8 631.3 564.1 561.1 714.2 625.5 636.6 571.8 - 609- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ ______________________________________________________ DuPont-11418 Study : e Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g g g g g g g9 9 Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Male, VII 1000 mg/kg 665031 665146 665062 665138 665112 665007 622.5 613.5 674.2 523.4 587.3 658.1 -610- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Qne-Generajtion Reproduction Evaluations Study: cem gBody Weight Day 0 Female, II 0 mg/kg gBody Weight; Day 7 Body Weight 3 Day;14 Individual Body Weights Body Weight Body Weight 3 Day 21 3 Day 28 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 . 665301 665269 665220 665334 665257 665175' 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 185.0 164.9 175.5 162.1 185.4 175.2 176.0 176.0 185.9 167.5 174.8 167.4 147.8 178.7 166.3 158.9 191.1 187.1 168.4 165.0 185.1 174.8 192.1 185.2 173.8 188.2 194.1 164.2 164.2 170.2 178.7 171.9 171.8 175.5 177.7 163.6 153.6 169.3 169.1 206.5 171.0 205.7 181.4 203.0 195.6 196.5 193.4 210.0 184.2 197.6 193.7 152.9 202.2 181.3 176.2 204.0 210.6 175.1 186.3 193.7 187.8 221.3 205.0 200.8 213.0 203.3 185.5 183.7 193.4 194.0 197.9 196.6 188.1 185.7 180.9 183.8 188.2 198.3 228.7 191.5 227.1 194.6 2^9.0 217.3 2 2.2 222.6 281.0 195.2 211.3 195.7 ibs.5 210.1 191.7 201.4 229.3 20.7.4 196.9 1 96.9 2 28.2 2 05.1 2 40.0 2 27.1 2 22.3 2 33.8 2 33.2 209.4 199.3 08.2 12.9 08.9 217.1 03.4 2 0 . 0 206.1 0 2 . 6 l!99.4 223.2 264.4 208.1 260.8 221.6 254.2 233.7 246.5 243.9 255.0 216.9 224.7 225.7 185.9 243.7 208.2 226.8 253.7 246.8 221.2 210.3 247.0 239.2 271.0 247.2 240.4 259.5 255.7 239.8 210.7 225.2 221.1 242.4 242.2 218.8 238.2 228.1 224.5 229.3 248.4 282.7 215.5 263.5 240.8 276.0 254.9 256.8 255.6 266.8 228.6 254.6 234.9 192.6 263.7 223.9 233.6 270.1 264.9 228.2 238.4 261.4 252.9 288.3 264.5 262.1 279.2 277.4 259.4 225.6 245.8 245.9 260.5 254.3 236.9 259.6 245.8 230.5 243.8 257.0 -611 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI g g g gBody Weight Body Weight Body Weight Body Weight Day 35 Day 42 nay 49 Day 56 293.4 214.8 283.5 253.1 284.0 271.8 270.1 261.4 290.3 231.7 263.6 237.2 195.5 269.7 226.7 235.2 277.2 269.8 239.4 242.6 262.1 249.8 288.1 273.5 273.4 284.6 279.7 261.0 239.0 257.6 253.5 271.2 259.4 246.8 278.8 244.4 253.0 264.9 279.4 305.8 233.8 300.5 257.8 280.0 276.4 284.0 273.4 271.1 242.7 272.5 244.2 206.4 274.5 234.9 249.1 292.1 266.6 253.3 246.2 284.9 267.7 310.5 272.5 282.2 297.6 303.0 278.2 250.7 264.4 261.2 278.7 272.2 258.7 285.1 266.8 264.4 272.5 289.4 326.5 242.5 311.5 269.8 302.7 281.9 295.1 290.3 289.6 252.0 285.0 261.0 211.4 294.0 231.3 260.9 293.3 289.0 262.9 260.7 298.4 283.0 328.1 286.6 289.4 303.4 314.2 289.1 247.4 284.9 273.2 294.4 273.1 257.0 285.7 272.9 270.2 288.4 306.5 344.4 246.8 313.6 274.8 311.0 289.2 297.0 294.7 284.1 259.1 285.1 265.4 212.2 299.5 240.0 263.8 299.2 292.6 264.6 266.3 300.1 279.0 323.0 294.2 296.9 303.2 321.2 289.6 259.5 280.3 273.1 305.8 274.3 266.7 308.3 278.0 272.1 291.6 306.8 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genen tion Reproduction Evaluations Study DuPont-11418 Individual Body Weights Body Weight g Day 0 Body Weight 3 Day 7 Body feight 1 Day 14 Body Weight 3 Day 21 Body Weight 'Body Weight 3 Day 28 3 Day 35 Body Weight 3 Day 42 Body Weight 3 Day 49 Body Weigh 3 Day 56 Female, II 0 mg/kg 665228 665260 665189 665204 665327 665203, 177.0 118.1 180.8 182.2 160.1 153.9 210.3 214.7 221.0 207.1 189.5 171.9 234.6 270.3 2f71.3 217.6 2,03.4 180.3 273.7 262.2 264.3 237.6 225.9 203.2 290.8 281.0 293.8 251.4 232.5 217.2 298.0 283.6 293.9 259.8 251.9 220.9 311.7 312.8 296.4 263.8 252.3 230.0 321.4 313.6 312.0 271.9 263.1 236.2 333.6 321.5 313.9 273.2 272.5 241.6 -612- H-25425: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations 2 tu d y gBody Weight Day 0 Female, IV 10 mg/kg gBody Weight Day 7 3Body Weight Day 14 Individual Body Weights gBody Weight Body Weight g Day 21 Day 28 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 195.0 156.9 172.3 161.3 187.6 173.8 181.1 176.7 163.8 167.2 175.0 167.3 177.1 171.9 161.1 155.8 168.8 203.5 152.9 190.6 174.7 170.3 182.3 184.0 171.0 191.4 191.0 200.3 158.7 154.0 160.0 171.5 157.9 143.4 174.3 212.2 161.0 * 197.2 177.7 218.0 197.5 212.0 199.3 189.5 185.9 188.2 192.7 203.4 183.7 188.0 181.7 193.9 226.9 183.0 213.5 203.4 180.9 199.0 217.7 195.6 211.3 224.5 219.5 180.9 174.9 178.6 203.6 183.2. 147.9 195.4 223.7 184.9 217.4 202.4 235.1 212.4 236.7 219.3 203.2 217.2 209.7 204.7 220.9 204.4 204.9 198.1 201.0 238.9 196.6 231.1 216.6 204.2 222.7 233.4 211.1 232.5 250.6 254.0 199.1 187.6 196.2 206.0 192.8 174.8 209.4 258.2 213.4 228.5 220.9 264.1 229.3 252.9 238.6 225.8 236.6 232.1 236.8 222.5 226.8 228.0 215.5 223.3 279.0 226.4 268.2 254.6 231.8 248.0 265.5 229.8 252.0 281.5 273.8 217.9 200.4 209.2 234.7 218.3 199.8 229.3 274.1 219.8 236.9 236.7 281.9 247.3 279.6 253.0 251.1 256.9 248.3 256.0 251.4 240.2 248.8 236.5 237.6 301.4 238.2 277.4 279.4 241.1 254.4 283.6 244.4 271.4 297.3 302.9 225.9 2 0 0 .4 225.4 243.1 241.5 208.1 240.9 -613- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Body Weight Body Weight Body Weight Body Weight g Day 35 g Day 42 g Day 49 g Day 56 283.6 222.1 255.7 237.2 295.5 260.1 287.8 264.1 244.5 274.6 251.5 262.8 265.6 244.3 256.7 241.8 247.3 307.5 246.2 283.9 284.1 244.4 268.0 294.7 242.7 275.0 313.2 317.3 246.7 218.9 227.8 245.3 256.5 214.4 241.7 291.0 238.8 272.8 251.0 295.8 262.4 297.5 266.0 267.9 268.9 274.5 269.8 271.0 261.5 266.4 253.2 257.0 323.6 259.9 293.2 304.8 262.2 273.5 312.0 256.6 292.2 320.6 324.0 258.5 225.2 233.1 274.6 260.2 228.1 260.7 296.1 244.2 273.7 262.9 318.2 258.8 304.8 272.1 282.6 286.8 284.3 283.3 264.2 268.3 277.8 264.5 256.4 348.7 276.3 308.1 310.2 271.7 279.6 301.5 255.1 297.1 333.2 329.4 273.2 226.9 237.4 279.7 263.5 235.7 268.6 312.5 250.2 273.6 263.8 323.3 268.4 311.6 284.5 275.8 295.3 291.3 285.1 281.3 275.7 283.1 265.9 264.3 351.9 281.2 314.1 320.8 272.0 282.1 320.9 259.7 307.2 342.6 340.7 281.8 225.4 245.1 285.2 275.6 239.3 276.2 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Body Weight Body Weight 3 Day 0 g Day 7 Female, VI 100 mg/kg Body Weight Day;14 Individual Body Weights Body Weight Body Weight 3Day 21 g Day 28 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233, 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 189.5 161.8 178.7 157.1 173.3 187.3 171.2 182.6 169.8 163.3 184.8 177.0 169.8 175.1 171.3 142.1 165.9 184.2 159.5 174.5 178.2 170.6 177.3 191.7 177.9 168.3 194.5 205.0 170.1 165.2 172.3 187.3 174.2 154.8 176.1 222.2 174.1 197.2 182.2 198.1 213.8 191.2 206.1 194.5 177.3 197.3 196.8 188.3 196 6 185.1 160.2 182.9 211 0 178.2 191 i 199^5' 196 2 209^7 211.2 203.8 189.5 222.1 225.2 191.2 186.5 189.8 198.6 193.1 179.3 204.5 236.8 204.7 2 6.2 199.2 2 1.2 2 6.2 207.4 29.3 22.4 1^7.7 2 j O .8 24.4 202.2 204.8 22.9 lt4.0 106.1 230.7 106.2 213.2 224.2 221.1 2^5.1 220.0 223.9 201.6 238.0 252.3 2L8.5 202.3 217.5 209.9 220.8 108.6 29.8 251.9 220.7 243.2 212.9 238.1 243.5 236.3 243.6 228.7 223.4 237.6 232.2 234.2 212.6 232.7 176.4 219.2 250.3 210.3 235.7 248.6 247.6 252.4 243.4 240.6 214.8 256.5 278.1 242.0 219.5 233.2 233.6 246.6 209.4 246.8 275.0 232.1 262.9 216.7 255.3 261.0 252.6 270.2 242.6 240.5 274.4 256.2 259.3 231.6 242.2 197.8 229.8 264.4 217.7 254.3 264.9 260.1 270.0 264.3 257.7 232.7 272.3 292.5 261.2 228.9 249.3 248.9 267.0 218.8 258.2 -614- DuPont-11418 Company Sanitized. Does not contain TSCA CBI Body Weight g i Day 35 Body Weight g Day 42 Body Weight g Day 49 Body Weight g Day 56 288.9 246.5 271.1 227.1 263.6 266.7 261.6 283.7 251.5 247.4 274.5 270.6 263.4 232.0 259.9 204.9 239.5 288.1 227.9 266.7 271.0 275.5 288.0 278.0 265.4 235.6 272.4 291.3 262.9 239.4 255.6 251.7 271.6 224.9 263.9 299.6 249.9 267.6 234.9 260.6 277.8 268.2 280.6 250.8 255.8 297.1 282.1 270.1 233.0 272.9 208.9 242.8 298.3 242.4 273.9 279.9 283.0 304.7 292.1 285.1 247.7 293.2 303.3 278.8 248.0 272.6 256.8 301.5 222.9 270.1 309.9 268.5 289.2 247.6 274.1 286.5 288.7 280.0 270.8 270.3 295.4 279.0 290.7 244.2 276.2 207.7 254.7 311.0 253.1 293.9 295.7 312.3 293.6 314.6 296.6 251.5 292.9 308.8 284.6 256.1 277.4 272.8 302.2 232.2 286.3 324.4 270.6 290.3 251.8 282.5 297.8 292.7 296.7 270.6 271.9 307.4 292.7 291.1 249.2 284.3 218.6 263.9 305.5 246.9 303.3 302.3 304.0 311.5 332.3 296.4 262.8 310.4 312.7 294.6 258.9 290.6 277.7 309.3 239.1 291.0 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generajion Reproduction Evaluations Study: em Body Weight Body Weight g Day 0 g Day 7 Female,, VIII 1000 mg/kg Body tteight i Day 14 Individual Body Weights Body Weight Body Weight g Day 21 g Day 28 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191* 665231 665288 665282 665275 665229 665237 665209 665335 183.0 165.0 169.5 163.7 186.6 165.0 172.7 178.3 183.9 159.4 159.8 170.4 164.7 175.3 155.9 152.4 191.5 163.0 165.7 179.6 176.8 187.3 183.8 170.2 177.9 183.8 152.8 169.4 194.6 153.0 151.4 160.8 177.4 186.1 158.0 152.3 157.5 165.1 167.4 209.5 191.7 183.4 195.4 208.2 181.7 196.3 206.8 205.9 188.4 180.9 198.3 189.8 200.6 176.1 157.7 214.1 180.9 175.4 206.7 200.5 214.0 199.9 190.4 200.0 208.7 163.0 193.1 217.8 176.2 181.0 183.5 207.5 218.5 174.9 180.4 173.2 186.0 191.6 2 8.8 215.4 200.9 2 ^6.6 2^9.2 187.5 109.8 231.9 226.4 199.7 195.0 223.1 206.5 25.2 176.1 l i .8 2 $1 .8 1?9.5 184.3 201.7 228.6 236.9 228.5 2 1 2 .7 2 0 . 6 224.2 li. 8 26.4 2 4 .4 lpl.5 190.7 204.1 216.6 205.2 197.2 202.2 105.4 205.8 2L5.8 233.4 236.7 227.8 238.1 252.7 207.4 227.6 253.5 244.7 214.7 213.9 237.1 227.1 232.9 202.4 178.3 257.9 214.3 205.4 242.2 253.8 258.3 256.5 224.9 223.5 243.4 198.9 238.1 277.2 209.6 218.4 218.3 253.7 '249.3 219.0 221.9 219.6 225.9 231.1 255.9 250.9 236.5 245.7 263.7 224.3 237.8 274.8 272.5 215.7 226.6 255.6 241.0 252.8 210.7 189.9 267.0 223.5 223.6 264.0 278.1 281.2 269.5 248.2 238.3 255.6 210.6 250.6 298.1 231.6 241.9 230.1 269.9 263.5 230.6 238.4 228.9 244.5 242.7 I j -615- DuPont-11418 Company Sanitized. Does not contain TSCA CBI 0Body Weight Body Weight Body Weight Body Weight g gg ; Day 35 Day 42 Day 49 Day 56 275.2 257.1 240.6 271.9 279.2 234.1 246.9 285.8 289.9 235.2 227.4 264.1 242.9 256.0 223.6 191.8 290.5 235.9 231.3 274.0 295.9 287.9 280.8 250.1 250.9 267.3 212.9 265.2 312.9 241.0 243.3 245.2 282.7 278.6 234.1 239.0 232.9 246.9 248.7 275.3 267.3 253.8 280.8 283.5 234.1 242.9 289.6 294.5 239.9 248.6 278.3 261.1 268.7 239.2 190.6 292.2 241.1 244.5 287.1 307.6 303.8 296.4 264.4 258.8 273.8 231.6 277.5 324.0 245.1 260.9 254.6 277.7 292.3 257.0 256.4 243.3 247.8 260.7 278.9 265.1 263.0 302.4 305.0 251.9 268.7 299.4 308.7 250.4 253.3 278.6 264.3 273.6 234.9 197.2 299.7 248.4 256.9 301.8 329.4 318.3 304.8 27.3.0 263.4 270.6 239.2 289.6 339.1 255.3 267.5 256.7 300.7 302.1 266.7 247.2 252.3 267.2 271.9 294.9 281.9 265.0 301.9 300.3 256.5 271.5 309.5 310.7 244.5 260.5 282.2 269.6 275.9 257.6 207.9 310.5 258.4 254.7 311.5 327.6 332.2 317.2 279.4 272.6 282.4 241.6 285.6 349.4 261.7 286.0 265.4 301.2 296.9 264.6 262.6 249.0 270.2 273.3 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: fern DuPont-11418 Individual Body Weights : g g g g g g g g gBody Weight Body Weight Body Weight Body Weight Body Weight SBody Weight Body Weight Body Weight Body Weight Day 0 Day 7 Day 14 Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 Female, VIII 1000 mg/kg 665303 665328 665299 665255 665213 665280 165.7 172.5 169.9 190.2 174.2 182.8 189.1 196.7 200.2 205.0 192.6 210.4 135.3 213.3 215.8 226.1 214.8 223.9 213.7 240.2 228.4 260.1 248.1 261.9 225.3 246.2 238.3 272.5 248.6 272.2 227.5 254.0 250.2 275.2 268.2 290.4 236.3 270.6 260.3 295.7 272.6 294.3 249.5 283.3 270.3 300.2 280.6 314.3 252.8 289.8 268.6 305.7 274.6 324.6 -616- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Body Weight g Day 63 Female, II 0 mg/kg Body Weight g Day 70 gBody Weight Day 77 Individual Body Weights Body Weight Body Weight gg Day 84 Day 91 665211 665271 665178 665317 665230 , 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 . 665249 665284 665240 665201 665197 665256 665323 665276 350.0 248.6 319.3 281.0 312.5 294.8 310.9 297.7 302.3 268.0 291.8 270.5 211.3 305.7 249.3 268.7 304.7 297.3 271.1 271.5 306.2 272.5 331.8 294.0 300.5 304.7 316.3 284.8 269.6 299.0 277.0 314.8 276.2 275.4 321.2 272.1 286.9 297.3 312.0 . 357.6 262.5 322.7 287.0 313.3 299.2 323.5 300.5 290.0 272.1 296.3 266.8 214.8 , 295.9 249.9 276.5 307.3 295.0 277.2 269.7 323.8 287.7 340.8 298.5 312.5 310.7 334.0 300.8 266.2 294.0 278.6 313.3 280.3 275.5 312.9 285.9 294,2 313.1 315.5 374.2 267.9 339.1 292.2 321.8 296.6 326.0 308.5 299.2 284.5 310.7 277.6 216.3 307.8 240.7 307.6 291.5 290.5 308.0 313.5 377.3 263.9 339.0 300.9 327.6 305.5 320.0 311.6 312.6 281.1 309.1 278.1 220.3 326.0 252.1 383.1 268.1 346.4 304.4 332.7 316.7 336.5 314.9 327.3 288.7 320.7 277.4 227.9 322.4 257.1 321.8 294.8 288.9 315.7 318.3 325.6 292.2 296.4 318.7 333.6 -617- Company Sanitized. Does not contain TSCA CBI ) DuPont-11418 g g g gBody Weight Body Weight Body Weight Body Weight y 98 Day 105 Day 112 Day 119 \ 314.5 279.3 234.7 332.4 249.6 345.1 287.5 236.9 332.9 260.6 356.5 296.5 240.1 341.2 274.4 349.8 287.3 242.5 348.0 277.8 325.1 300.1 303.6 329.7 320.5 330.5 311.2 303.0 330.5 336.3 342.0 309.3 305.6 332.6 336.5 344.7 309.0 312.9 349.8 356.8 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: ifem DuPont-11418 Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g g g g g g g g gS Day 63 Day 70 Day 77 Day 84 Day 91 Day 98 Day 105 Day 112 Day 119 Female, II 0 mg/kg 665228 665260 665189 665204 665327 665203 314.4 331.2 321.9 279.0 274.4 242.3 327.3. 328.6 327.6 275.6 272.0 242.5 1333.5 334.3 [319.4 289.6 279.7 339.5 348.4 324.6 290.7 291.0 336.4 357.2 324.1 287.5 289.1 ^ 343.2 370.5 319.2 287.9 284.1 352.8 400.8 338.1 290.9 299.4 355.7 406.2 338.8 304.0 302.8 387.8 414.3 337.3 303.9 296.8 -618- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Company Sanitized. Does not contain TSCA CBI Body Weight g Day 63 Female, IV 10 mg/kg Body Weight g Day 70 Body Weight & Day] 77 Individual Body Weights Body Weight Body Weight Body Weight 9 Day 84 9 Day 91 g Day 98 Body Weight 9 Day 105 Body Weight 9 Day 112 Body Weight g Day 119 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218, 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 317.0 243.5 280.5 277.1 318.0 288.9 321.6 283.5 286.5 305.5 284.2 293.4 289.0 276.8 291.9 276.1 276.6 356.4 282.0 321-8 321.2 269.7 284.6 328.5 260.9 299.2 347.2 336.2 293.3 235.4 250.4 287.0 281.5 247.4 286.6 311.7 258.7 291.4 284.5 335.2 277.2 321.0 290.0 295.3 310.1 305.2 298.3 286.4 292.0 286.0 282.2 281.3 359.2 287.3 , 319.3 325.9 277.6 284.5 325.5 265.7 304.9 347.3 333.4 295.3 235.7 245.3 287.5 275.7 261.2 279.9 3 25.0 2 53.9 2 95.0 2 B4.6 342.1 2 76.8 354.7 286.7 2&1.9 2199.8 3b7.8 3b5.4 281.2 aQ n 2 65.2 321.6 262.2 290.5 286.3 353.4 290.5 328.4 292.1 299.0 311.0 314.4 314.4 281.7 305.7 293.9 322.8 251.4 298.6 287.2 352.0 294.7 337.9 299.8 307.3 316.7 303.5 312.1 301.0 300.0 295.5 317.3 318.1 299.9 307.9 297.3 322.0 341-5 303.5 315.2 305.1 329.0 345.8 306.3 322.3 310.7 336.8 346.0 323.1 315.7 304.4 H-25425: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: :em DuPont-11418 Company Sanitized. Does not contain TSCA CBI Individual Body Weights Body Weight Body Weight Day 63 Day 70 Female, VI 100 mg/kg Body Weight Day 77 Body Weight Day 84 Body Weight Day 91 Body Weight Day 98 Body Weight 9 Day 105 Body Weight g Day 112 Body Weight g Day 119 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274. 665272 665195 665314 665316 665173 334.5 270.6 299.1 260.1 291.8 304.5 291.0 300.5 277.9 252.1 314.2 300.7 299.8 256.1 289.0 231.6 269.6 325.5 256.0 311.8 301.0 317.5 304.0 340.4 307.4 274.0 309.5 312.3 301.9 262.4 287.8 276.3 314.0 241.4 297.1 . 335.3 287.2 301.4 269.4 288.2 304.4 293.0 306.0 278.3 273.6 320.4 304.4 292.5 256.3 294.1 225.1 265.6 325.5 261.0 310.7 310.4 318.8 316.0 336.5 323.2 271.2 315.2 321.2 301.4 268.1 292.5 274.5 322.4 241.1 296.1 * 339.5 290.2 310.6 274.5 298.6 303.0 300.0 299.9 281.7 286.5 316.5 306.8 296.9 260.4 287.7 341.0 298.6 315.6 271.5 300.3 310.3 304.4 310.3 285.3 286.3 336.5 33.0.7 307.5 270.3 300.4 339.9 295.8 318.6 286.8 301.1 308.6 305.8 315.4 292.5 288.9 343.2 324.1 300.9 273.1 301.0 341.0 322.5 309.5 276.3 301.4 348.3 323.3 331.9 295.9 313.5 351.5 342.9 333.3 291.3 323.9 357.5 345.8 329.6 292.6 325.6 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: .fem Body Weight Body Weight g Day 63 g Day 70 Female, VIII 1000 mg/kg Body Weight g Day 77 Individual Body Weights Body Weight Body Weight gg Day 84 Day 91 665234 665242 665183 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320' 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665288 665282 665275 665229 665237 665209 665335 312.8 285.5 265.8 301.6 317.0 267.7 275.5 311.2 326.1 263.1 265.7 291.1 295.9 284.3 259.5 217.1 304.5 248.8 260.5 315.4 332.5 346.1 320.4 288.1 275.9 281.5 233.9 300.3 341.3 263.0 282.6 258.8 307.1 312.2 266.8 274.6 250.7 278.7 277.4 309.2 293.7 276.1 302.1 319.9 266.9 279.0 309.0 344.0 260.6 283.0 291.7 283.1 285.7 266.5 221.1 323.3 268.6 270.0 322.4 341.0 356.1 320.4 284.6 275.0 285.1 * 250.6 296.1 361.3 266.6 ^ 289.4 272.7 305.7 306.8 276.2 274.4 256.8 276.5 280.0 308.8 293.7 281.0 316.0 321.8 278.3 293.8 323.3 337.0 272.2 288.9 298.2 301.5 287.8 262.8 312.4 319.3 279.1 270.7 267.7 282.7 288.9 321.5 295.2 278.5 325.3 321.3 287.9 295.9 322.6 349.0 266.4 293.2 300.8 296.5 295.6 269.4 318.6 318.4 279.8 282.8 265.3 291.8 288.9 328.9 302.6 279.2 328.1 330.7 285.8 302.2 329.6 349.9 277.2 292.0 309.7 296.5 296.9 277.6 318.5 329.4 267.6 284.8 266.8 280.6 290.5 -621 - Company Sanitized. Does not contain TSCA CBI DuPont-11418 g g g gBody Weight Body Weight Body Weight Body Weight ' 98 Day 105 Day 112 Day 1X9 292.3 312.8 286.2 296.7 282.8 308.1 316.2 313.9 309.9 294.8 315.9 325.1 310.6 316.4 312.5 318.6 323.3 312.7 317.1 305.6 322.3 337.1 284.6 286.0 274.6 292.9 300.2 332.0 352.6 294.4 288.0 283.8 304.5 307.4 335.8 353.5 304.3 300.8 278.6 300.7 308.4 350.5 351.4 313.9 293.3 275.7 312.0 313.7 Company Sanitized. Does not contain TSCA CBI ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: |fem ) DuPont-11418 Individual Body Weights g g g g g gBody Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g9g Day 63 Day 70 Day 77 Day 84 Day 91 Day 98 Day 105 Day 112 Day 119 Female, VIII 1000 mg/kg 665303 665328 665299 665255 665213' 665280 255.7 288.0 277.5 306.1 293.5 325.5 268.8 301.7 286.6 318.2 306.6 339.0 275. 0 303. 5 280. 0 272.3 308.3 278.9 269.4 305.9 280.0 277.2 318.7 287.8 288.1 329.3 288.2 296.0 355.6 292.1 293.6 334.2 295.5 -622- Company Sanitized. Does not contain TSCA CBI > ") H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g Day 126 g Day 133 g Day 140 g Day 147 g Day 154 g Day 161 g Day 168 g Day 175 g Day 182 Female, II 0 mg/kg 665211 665271 665178 665317 665230 665225 665174 665319 665221 665278 665176 665283 665297 665301 665269 665220 665334 665257 665175 665336 665192 665232 665307, 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665201 665197 665256 665323 665276 363.8 284.5 248.0 349.4 273.2 346.7 315.3 320.2 345.2 352.4 374.7 288.3 254.4 357.2 268.7 375.7 287.3 261.5 375.1 280.6 383.3 287.4 253.5 379.2 277.7 376.4 293.9 246.8 387.0 280.0 401.6 295.0 254.1 403.5 280.8 385.7 288.8 252.0 399.8 289.7 394.2 288.6 258.8 410.9 284.7 391.9 296.1 262.5 413.8 292.8 623- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-11418 Study: :em Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight g Day 126 9 Day 133 g Day 140 g Day 147 g Day 154 g Day 161 g Day 168 g Day 175 g Day 182 Female, II 0 mg/kg 665228 665260 665189 665204 665327 665203 384.2 417.0 346.8 309.9 296.4 - 624 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Study: :em Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight 9 ' Day 126 3 Day 133 3 Day 140 3 Day 147 3 Day 154 Female, IV 10 mg/kg 665308 665215 665277 665241 665236 665324 665332 665239 665182 665268 665218 665309 665177 665202 665235 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286' 665281 665186 665330 665294 665244 665258 352.1 344.2 322.9 326.2 302.2 354.6 355.5 321.2 331.2 309.2 356.5 353.3 340.0 334.0 315.5 351.1 361.2 336.0 333.0 307.7 363.5 355.1 335.8 344.2 312.8 Company Sanitized. Does not contain TSCA C8I DuPont-11418 Body Weight Body Weight Body Weight Body Weight 9 Day 161 g Day 168 g Day 175 g Day 182 382.5 374.7 336.0 350.5 324.6 378.6 371.5 335.9 345.7 318.8 380.9 372.6 339.9 350.7 326.0 391.4 370.5 353.6 356.2 328.7 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight g Day 126 g Day 133 g Day 140 g Day 147 g Day 154 Female, VI 100 mg/kg 665295 665251 665300 665340 665259 665341 665199 665238 665250 665170 665313 665233 665216 665266 665270 665338, 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 356.1 348.8 330.8 287.9 330.9 368.9 349.0 341.8 301.3 344.7 382.4 368.8 349.2 305.7 348.1 - 372.0 368.7 348.3 309.1 343.2 380.9 366.6 348.7 313.6 352.0 - 626- Company Sanitized. Does not contain TSCA CBI DuPont-11418 Body Weight Body Weight Body Weight Body Weight g Day 161 g Day 168 g Day 175 g Day 182 390.2 376.7 360.1 316.3 363.2 380.4 367.8 364.0 314.1 363.4 391.8 383.3 362.5 310.2 371.8 396.1 377.9 367.5 322.2 376.7 Company Sanitized. Does not contain TSCA CBI ) ;) ) H-25425: Subchronic Toxicity ' 90-Day Gavage Study in Rats with One-Generajtion Reproduction Evaluations_______________________________________________________________ DuPont-11418 Individual Body Weights Body Weight Body Weight Body ijjeight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight S Day 126 g Day 133 Day ;140 g Day 147 g Day 154 g Day 161 g Day 168 g Day 175 g Day 182 Female, VIII 1000 mg/kg 665234 665242 665183 , 665261 665291 665337 665333 665200 665310 665326 665302 665179 665287 665172 665194 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 . 665169 665191 665231 665288 665282 665275665229 665237 665209 665335 316.5 335.9 320.0 316.4 309.3 342.7 366.4 306.9 301.1 290.2 302.0 312.5 314.5 336.2 317.0 323.7 327.3 . 320.8 342.8 324.2 333 .7 328.4 333.0 341.7 337.2 323.0 331.2 336.9 341.1 341.0 332.3 327.3 340.6 357.9 355.4 343.9 340.9 349.4 358.4 353.7 346.9 338.1 350.3 364.0 366.3 358.6 342.6 352.7 368.8 375.8 354.5 351.5 - 627- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________ Study: Eem .__________ DuPont-11418 Individual Body Weights Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight Body Weight sgggggggg Day 126 Day 133 Day 140 Day 147 Day 154 Day 161 Day 168 Day 175 Day 182 Female, VIII 1000 mg/kg ' 665303 665328 665299 665255 665213 665280 290.9 329.3 294.9 -628-