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INFORMATION SOURCES ON INDUSTRIAL TOXICOLOGY Prepared by Susan W. Snyder Haskell Laboratory for Toxicology and Industrial Medicine E. I. du Pont de Nemours For AIHA Toxicology Seminar Newark, NJ - October 17-18, 1978 This compilation of references on toxicology and industiral hygiene contains those references found to be useful by the Haskell Laboratory Information and Indus trial Hygiene sections. Items marked with an asterick (*) are considered particularly valuable. This collection is by no means a comprehensive list of the abundant literature on the subject. OUTLINE I. GENERAL TEXTS II. TOXICOLOGY OF SPECIFIC CHEMICALS A. Aromatic Hydrocarbons B. Fluorine Compounds C. Metals a) General b) Specific Metals D. Pesticides E. Plastics F. Solvents OR CLASSES III. OCCUPATIONAL DISEASES OFSPECIFIC A. Lung . B. Skin C. Eyes D. Behavioral Toxicology ORGANSOR SYSTEMS IV. SPECIAL TOPICS A. Cancer and Carcinogenesis B. Mutagenicity C. Embryotoxicity andTeratogenicity D. Aquatic Toxicity E. Poisoning P. Labeling G. Transportation V. SUPPLEMENTARY REFERENCES - CHEMICAL HANDBOOKS, DICTIONARIES, AND TRADE NAME INDEXES VI. SECONDARY SOURCES A. Abstracts and Indexes VII. COMPILATIONS A. Toxicity Data B. Testing in Progress VIII. MISCELLANEOUS GUIDES IX. INDUSTRIAL HYGIENE A. Air Standards B. Background for Standard Development C. Air Monitoring, Sampling, and Analysis D. Odor and Taste Thresholds FEDERAL REGULATIONS XI. NEWSLETTERS - CURRENT AWARENESS XII. ONLINE COMPUTER DATA BASES A. Chemical Dictionary Files B. Bibliographic Files C. Other Files R A i... 0 0 0 0 4 6 / / 4 PAGE 1 3 3 3 3 4 7 7 7 8 8 8 8 9 10 10 10 11 11 12 12 12 14 15 15 17 18 18 19 20 20 21 21 24 25 26 27 27 28 I. GENERAL TEXTS Casarett, L. J. and Doull, J. eds., Toxicology, The Basic Science of Poisons. Macmillan Publishing Co., N.Y. (1975). Clayton, G. D. and Clayton, F. E., Patty's Industrial Hygiene and Toxicology, Vol. I General Principles, 3rd ed. John Wiley and Sons, nTy. (1978). Deichmann, W. B. and Gerarde, H. W. , Toxicology of Drugs and Chemicals 4th ed. Academic Press, N.Y. (1969). Elkins, H. B., The Chemistry of Industrial Toxicology, 2nd ed. John Wiley and Sons , N. Y. fl959)l Fairhall, L. T., Industrial Toxicology, 2nd ed. Hofner, N.Y. (1969). Gosselin, R. E. et al.. Clinical Toxicology of Commercial Products, Acute Poisoning, 4th ed. Williams and Wilkins Co., Baltimore (1976). Hamilton, A. and Hardy, H. L., Industrial Toxicology, Publishing Sciences Group, Inc., Acton, Massachusetts (1974). The Industrial Environment - Its Evaluation and Control HEW-NIOSH (1973). International Labour Office. Encyclopedia of Occupational Health and Safety, 2 Vol. (1971-2) International Labour Office, CH1211, Geneva 22, Switzerland. Loomis, T. A., Essentials of Toxicology, 2nd ed. Lea & Febiger, Philadelphia (1974). Mehlman, M. A. et al.. Advances in Modern Toxicology - New Concepts in Safety EvaTuation7 VoTI 1 Part 1 John Wiley and Sons, N.Y. (1976) (Parts 2 and 3 in preparation) *Patty, F. A. ed., Industrial Hygiene and Toxicology, Vol, II. Toxicology, Interscience, N.Y. (1963) (3rd ed. available 1980). Patty's Industrial Hygiene and Toxicology, Vol. III. Theory and Rationale of Industrial Hygiene Practice Wiley - Interscience , N.Y. (to be available 1979). Plunkett, E--.R. , Handbook of Industrial Toxicology, 2nd ed. Chemical Publishing Co . , N.Y. (1976). 1 000046 7/5' I. GENERAL TEXTS (CQNT1D) Principles and Procedures for Evaluating the Toxicity of Household Substances, National Academy of Sciences, Washington, D. C. (1977). Rudd, R. L. , .Environmental Toxicology ~~ A Guide to Information Sources, Gale Research Co., Detroit, Michigan 48226. Toxic and Hazardous Industrial Chemicals Safety Manual for Handling and Disposal With Toxicity and HazarcTData, ToEyol International Technical Information Institute (1975). 2 II. TOXICOLOGY OF SPECIFIC CHEMICALS OR CLASSES A. Aromatic Hydrocarbons Gerarde, H. W., Toxicology and Biochemistry of Aromatic Hydro carbons , . Elsevier Publishing Co., N.Y. (1960). B. Fluorine and Compounds Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Science, Biological Effects of Atmospheric Pollutants - Fluorides, National Academy of Sciences, Washington, Dl Cl (1971) . Eagers, R. Y., Toxic Properties of Inorganic Fluorine Compounds, Elsevier Publishing Co., N.Y. (1969). Pallison, F. L. M., Toxic Aliphatic Fluorine Compounds, Elsevier Publishing Co., N.Y. (1959). * World Health Organization, Fluorides and Human Health, WHO Monograph Series No. 59~, World Health Organization, Geneva, Switzerland (1970). C. Metals a) General Browning, E., Toxicity of Industrial Metals, 2nd ed., Butterworth and Co., LtdT, London, England (1969). Goyer, R. A. and M. A. Mehlman, Advances in Modern Toxicology Toxicology of Trace Elements (Vol. 21 John Wiley and Sons, N.Y. (1977). Lee, D. N. K., Metallic Contaminants and Human Health, Academic Press, N.Y. (1972). Nordberg, G. F., Effects and Dose-Response Relationships of Toxic Metals, Elsevier Scientific Publishing-Co.N.Y. (19 7 6l . ~ 3 .. /\ A A / Bv\b. o00''>! II. TOXICOLOGY OF SPECIFIC CHEMICALS OR CLASSES (CONT'D) b) Specific Metals Arsenic Buchanan, W. D., Toxicity of Arsenic Compounds, Elsevier Publishing Co, ,_N~.Y. (1962) . Beryllium Stokinger, H. E. ed.. Beryllium: Its Industrial Hygiene Aspects, Academic Press, N.y"! (1966) , ' Tepper, L. B. et al., Toxicity of Beryllium Compounds, Elsevier Publishing Co., N.yl (1961). Cadmium Criteria (Dose/Effect Relationships) for Cadmium, Pergamon Press for the Commission of the European Communities (1978). Friberg, L. et al.. Cadmium in the Environment, 2nd ed., CRC Press, Inc., Cleveland, Ohio (1974). Chromium Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Sciences, Medical and Biological Effects of Environmental Pollutants--Chromium, National Academy of Sciences, Washington, fT. C"I (1974) . Copper Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Sciences, Medical and Biological Effects of Environmental Pollutants--Copper, National Academy of Sciences, Washington, C^ XT977T. r.'J 4 oOA II. TOXICOLOGY OF SPECIFIC CHEMICALS OR CLASSES (CONT'D) Lead Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Sciences, Medical and Biological Effects of Environmental Pollutants--Lead, National Academy of Sciences'7 Washington, D. C. (1972) . Manganese Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Sciences, Medical and Biological Effects of Environmental Pollutants--Manqanese, National Academy of Sciences,Washington, 5"! c". (1973) . Mercury Bidstrup, L. P., Toxicity of Mercury and Its Compounds, Elsevier Publishing Co., N.Y. (1964) . Friberg, L. T. and Vostal, J. J., Mercury in the Environment, Chemical Rubber Co., Cleveland^ Ohio (1972). Nickel Committee on Medical and Biologic Effects of Environmental Pollutants, National Research Council, National Academy of Sciences, Medical and Biologic Effects of Environmental Pollutants--Nickel, National Academy of Sciences, Washington, D. Cl (1975). Platinum Committee on Medical and Biologic Effects of Environmental Pollutants, National Research Council, National Academy of Sciences, Medical and Biologic Effects of Environmental Pollutants--Plat3-num.Group Metals, National Academy of Sciences (1977). SAL 000046' 5 II. TOXICOLOGY OF SPECIFIC CHEMICALS OR CLASSES (CONT'D) Selenium Committee on Medical and Biologic Effects of Environmental Pollutants, National Research Council, National Academy of Sciences, Medical and Biologic Effects of Environmental Pollutants--Selenium, National Academy of Sciences, Washington, D. C. (1976) . Thallium Prick, J. J. G., et al., Thallium Poisoninq, Elsevier Publishing Co., N.Y. (1955). Thorium Albert, R. E., Thorium: Its Industrial Hygiene Aspects, Academic Press, N.Y. (1966T. Uranium Voegtlin, C. and Hodge, H. C. eds., Pharmacology and Toxicology of Uranium Compounds, McGraw-Hill Book Co., nVy. (1949-1953), 4 Vols. Vanadium Committee on Biologic Effects of Atmospheric Pollutants, National Research Council, National Academy of Sciences, Medical and Biologic Effects of Environmental Pollutants--Vanadium, National Academy-of Sciences^ Washington, C~. (1974) . Hudson, T. G. F., Vanadium, Toxicology and Biological Significance, Elsevier Publishing Co., NVY. (1964) . ' 000046'/ Bb' 6 II. TOXICOLOGY OF SPECIFIC CHEMICALS OR CLASSES (CONT'D) D. Pesticides Guide to the Chemicals Used in Crop Protection/ Publication 1093, 6th ed., Catalog No. A43-1093. Information Canada, Ottowa (1973). Hayes, W. J. Jr., Toxicology of Pesticides, The Williams and Wilkins Co., Baltimore (1975). Matsumuru, F., Toxicology of Insecticides, Plenum, N.Y. (1975). The Mrak Report, Index to the Report of the Secretary's Commission on Pesticides and Their Relationship to Environmental Health, U.S. Department of Health, Education, and Welfare, Government Printing Office, Washington, D. C. Publication No. 20,3602. Pesticide Chemicals Official Compendium, Association of American Pesticide Control OfficTals, Inc., Kansas State Board of Agriculture, 1032-S State Office Building, Topeka, Kansas 66606, (1966). E. Plastics Malten, K. E. and Zielhuis, R. L., Industrial Toxicology and Dermatology in the Production and Processing of Plastics, Elsevier Publishing CoY, nTyI (1964). F. Solvents Browning, E., Toxicity and Metabolism of Industrial Solvents, Elsevier Publishing Co., N.Y. (1965). Handbook of Organic Industrial Solvents, Technical Guide No. 6, 4th ed., American Mutual Insurance Alliance, Chicago, Illinois (1972). q ,a j 00004679 :t. 7 III. OCCUPATIONAL DISEASES OF SPECIFIC ORGANS OR SYSTEMS A. Lung Hatch, T. F. and Gross, P., Pulmonary Deposition and Retention of Inhaled Aerosols, Academic Press, N.Y. (1964). Muir, D. C. F. ed., Clinical Aspects of Inhaled Particles, F. A. Davis, Co.", Philadelphia^ PA (1972)^ B. Skin Adams, R. M., Occupational Contact Dermatitis, J. B. Lippincott Co Philadelphia, PA (1969). *Fisher, A. A., Contact Dermatitis, 2nd ed., Lea and Febiger, Philadelphia^ PA (1969). Fregert, S., Manual of Contact Dermatitis, Yearbook Medical Publisher! (1974) . Fregert, S. and H. J. Bandmann, Patch-Testing, N.Y. (1975). Springer-Verlag Marzulli, F. N. and Maibach, H. I., Advances in Modern Toxicology Dermatotoxicology and Pharmacology (Voi. 4), John Wiley andSons, N.Y. (1977)7 C. Eyes Carpenter, C. P. and H. F. Smyth, Jr., Chemical Burns of the Rabbit Cornea, Am. J. Opthalmol. 29:1363 (1946). *Grant, W. M., Toxicoloqy of the Eye, 2nd ed. C. C. Thomas, Springfield, 111. (1974) . Smith, M. B., Handbook of Ocular Toxicity, Publishing Sciences Group, Inc. (1976). III. OCCUPATIONAL DISEASES OF SPECIFIC ORGANS OR SYSTEMS (CONT'D) D, Behavioral Toxicology Behavioral Toxicology, Early Detection of Occupational Hazards, Xintaras, C. ed., HEW, Public Health Service, NIOSH (1974). Rochester International Conference on Environmental Toxicity, 5th, Weiss, B.--and V. G. Laties, ed.. Plenum Press, N.Y. (1975). ':) A L 0 0 0 O *4 6 9 IV. SPECIAL TOPICS A. Cancer and Carcinogenesis Cancer and the Worker, New York Academy of Sciences N.Y. (1978). *IARC (International Agency for Research on Cancer), Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Vol.~1~(T9T2 ) - Vol. 17 (1978) World~Health Organization, N.Y. Kraybill, H. F. and Mehlman, M. A., Advances in Modern Toxicology Environmental Cancer (Vol. 3) John Wiley and Sons, N.Y. (19/7) National Cancer Institute Carcinogenesis Technical Report Series, (Results of bioassays for carcinogenicity of chemicals in test animals), Technical Information Resources Branch, National Cancer Institute, Landow Building, Bethesda, MD 20014. *Searle, C. E., Chemical Carcinogens, American Chemical Society ACS Monograph 173 (1^7 6^1 Survey of Compounds Which Have Been Tested for Carcinogenic Activity, C7. S~. Public Health Service Publication14 9. 1951 2nd ed. Hartwell. J. L. 1957 Supplement I Shubik, P. and J. L. Hartwell 1969 Supplement II Shubik, P. and J. L. Hartwell 1968-9 Volume 1961-7 Volume Sections I and II 1970-1 Volume 1972-3 Volume (available microfiche only) B. Mutagenicity Flamm, W. G. and Mehlman, M. A., Advances in Modern Toxicology Mutagenesis (Vol. 5) John Wiley and Sons, N.Y. (1978). Hollaender, A., Chemical Mutagens, Vol. 4 Plenum Press (1976). 10 IV. SPECIAL TOPICS (CONT'D) B. Mutagenicity (cont'd) McCann, J. et al.. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals, Proc. Natl. Acad. Sci. USA 72(12):5135-9 (1975). Purchase, I. et al., Evaluation of six short-term tests for detecting orqanic chemical carcinoqns, Br. J. Cane. 37(6):873-36 (1978). Sugimura, T. et al., Overlapping of Carcinogens and Mutagens, Fundamentals in Cancer Prevention, P. N. Magee et al., eds. Univ. Park Press, Baltimore, MD, p. 191-215 (1976). C. Embryotoxicity - Teratogenicity Schardein, J. L., Drugs as Teratogens, CRC Press (1976). Shepard, T. H., Catalog of Teratogenic Agents, 2nd ed., Johns Hopkins University Press, Baltimore, MD (1976). Weinstein, L. ed., Teratology and Congenital Malformation. A Comprehensive Guide to theLXterature, VoI. I-111, IFI/Plenum N.Y. {1916) (also contained in NLM's Toxline data base). D. Aquatic Toxicity Koeman, J. H. and J. J. T. W. A. Strik, Sublethal Effects of Toxic Chemicals on Aquatic Organisms"! Elsevier (1975) . *McKee, J. E. et al., Water Quality Criteria, 2nd ed. Resources Agency of California, State Water Quality Control Board, Publication No. 3-A (1963) . Water Quality Criteria (A report prepared by the National Academy of Sciences for the Environmental Protection Agency) GPO Stock No. 5501-00520 (1972, Revised 1976). 11 ohI 0C 004 6 7 S'5 IV. SPECIAL TOPICS (CONT'D) D. Aquatic Toxicity (Cont'd) Water Quality Criteria, Report of the National Technical Advisory Committee to the Secretary of the Interior. U.S. Department of Interior (1968). Water Quality Criteria Data Book, Vol. 5, Effects of Chemicals on Aquatic Life, Environmental Protection Agency (1973). E. Poisoning Arena, J. M., Poisoninq, 3rd ed. C. C. Thomas Sprinqfield, 111. (1974). Dreisbach, R. H., Handbook of Poisoning Diagnosis and Treatment, 9th ed. Lange Medical Publications Los Altos, California (1977). See also Deichmann and Gerarde (1969) and Gosselin, et al., (1976) listed above under General Texts. F. Labeling Guide to Precautionary Labeling of Hazardous Chemical, Manual L-l 7th ed., Manufacturing Chemists Association, Washington, D. C. (1970). Labeling ANSI Z-129.1 (1976). G. Transportation Hazardous Materials Regulations of the Department of Transportation, R. M. Graziano's Tariff No. 31, (March 31, X97TJ (also found in 49 CFR 170-179). IATA Restricted Articles Regulations, 17th ed. International Air Transport Association, p"! 0^ Box 315, 1215 Geneva 15 Airport, Switzerland (July 1974). --J / SAi12 IV. SPECIAL TOPICS (CONT'D) G. Transportation (Cont'd) International Maritime Dangerous Goods Code, Vol. I-IV, Intergovernmental Maritime Consultative Organization, London (1977). (,000 13 V. SUPPLEMENTARY REFERENCES - CHEMICAL HANDBOOKS, DICTIONARIES, TRADE NAME INDEXES *Blackiston1s Gould Medical Dictionary, Osol, A. ed., McGraw Hill, N.Y. (1972). *The Condensed Chemical Dictionary, Hawley, G. G. ed. (latest ed.) Van" Nostrand Reinhold, N.Y". CRC Handbook of Chemistry and Physics, Weast, R. C. ed. (latest ed.) The Chemical Rubber Company, 18901 Cranwood Parkway, Cleveland, Ohio 44128. CTFA Cosmetic Ingredient Dictionary, 2nd ed., The Cosmetic, Toiletry and Fragrance Association (1977). Desktop Analysis Tool for the Common Data Base, American Chemical Society^ (1968) . Dorland's Illustrated Medical Dictionary, Saunders Philadelphia (latest ed.). The Merck Index, Windholz, M. ed., 9th ed. Merck and Company Rahway, New Jersey (1976). Pharmacological and Chemical Synonyms, Marler, E. ed., Excerpta Medica," Amsterdam (19^76^K* *SOCMA Handbook: Commercial Organic Chemical Names, American Chemical Society, Washington, D~, C~. (19 65)~ Trade Names Index and Supplements, American Conferences of Governmental Industrial Hygienists, Cincinnati, Ohio. Note: Gosselin, et al., Clinical Toxicology of Commercial Products. Acute Poisonings (1976) also contains compositions of trade name products and representative formulations of products commonly found in the home or farm. 14 VI. SECONDARY SOURCES A. Abstracts and Indexes Abstracts on 'Health Effects of Environmental Pollutants. BioSciences Information Service, 2T00 Arch. St. Philadelphia, PA 19103. Monthly (Selected citations from Biological Abstracts, Bioresearch Index and National Library of Medicine's MEDLARS (Medical Literature Analysis and Retrieval System). Air Pollution Abstracts, Office of Air Quality Planning and Standards, U.S. Environmental Protection Agency, Superintendent of Documents, U.S. Governmental Printing Office, Washington, D. C. 20402. Biological Abstracts, BioSciences Information Service, 2100 Arch St. Philadelphia, PA 19103. *Chemical Abstracts, American Chemical Society, Office of the Controller, 1155 Sixteenth St. N.W. Washington, D. C. 20006. Biweekly. (Especially useful are section .3 for mutagenicity, 4 for toxicology and 59 for air pollution and industrial hygiene). CIS Abstracts (formerly Occupational Safety and Health Abstracts) International Labour Office, Suite 330, 1750 New York Avenue, N.W. Washington, D. C. 20006. Monthly. Industrial Hygiene Digest, Industrial Health Foundation, Inc. 5231 Centre Ave., Pittsburgh, PA 15232. Monthly. Index Medicus, National Library of Medicine, Bethesda, MD. Monthly. National Technical Information Service Weekly Government Abstracts: Environmental Pollution and Control, Medicine and Biology*) NTIS, Washington, D. C. Current Contents - Agriculture, Biology, and Environmental Sciences and Life Sciences - Institute for Scientific Information, Inc. 325 Chestnut St. Philadelphia, PA 19106 Weekly (Offset reproductions of journal Tables of Contents with author index and address directory). 15 - ?v VI. SECONDARY SOURCES (CONT'D) A. Abstracts and Indexes (Cont'd) Toxicity Bibl-iography, National Library of Medicine, Superintendent of Documents, U.S. Government Printing Office, Washington, D. C. 20402. Quarterly (Sub-set of NLM's MEDLARS file of citations from Index Medicus). Toxicology Abstracts, Information Retrieval Limited, London. 000046790 16 VII. COMPILATIONS A. Toxicity Data The Place of -the Range Finding Test in the Industrial Toxicology Laboratory, H. F. Smyth, Jr. and C. P. Carpenter, J. Ind. Hyg. Toxicol., 26:26 9-273 (194 4) . Further Experience with the Range Finding Test in the Industrial Toxicology Laboratory, H. F. Smyth, Jr. and C. P. Carpenter J. Ind. Hyg. Toxicol., 30:63-68 (1948). Range-Finding Toxicity Data, List III, H. F. Smyth, Jr., et al., J. Ind. Hyg. Toxicol., 31: 60-62 (1949) . Range-Finding Toxicity Data, List IV, H. F. Smyth, Jr., et al., AMA Arch. Ind. Hyg., 4:119-122 (1951) . Range-Finding Toxicity Data, List V, H. F. Smyth, Jr., et al., AMA Arch. Ind. Hyg. Occup. Med., 10:61-68 (1954). Range-Finding Toxicity Data, List VI, H. F. Smyth, Jr., et al.. Am. Ind. Hyg. Assoc. J., 23:95-107 (1962). Range-Finding Toxicity Data, List VII, H. F. Smyth, Jr., et al.. Am. Ind. Hyg. Assoc. J., 30:470-476 (1969). Range-Finding Toxicity Data, List VIII,- C. P. Carpenter, et al., Toxicol. Appl. Pharmacol., 28 :313-319 (1974). The Subacute Inhalation Toxicity of 109 Industrial Chemicals, J. C. Gage, Brit. J. Ind. Med., 27:1-18 (1970). Range-Finding Toxicity Data for 43 Compounds, Chemical-Toxicological Series, Bulletin No. 6, W. E. Rinehart, et al.. Industrial Hygiene Foundation of America, Inc., 4400 Fifth Ave., Pittsburgh, PA (1967), 11 p. Handbook of Toxicology. Vol. I. Acute Toxicities, WADC Tech. Rept. 55-16, W. S. Spector, ed., Wright Air Development Center, Wright-Patterson Air Force Base, Ohio (April, 1955), 408 p. SAL 00004 17 VII.___ COMPILATIONS (CONT'D) A. Toxicity Data (Cont'd) The Assay of Acute Vapor Toxicity and the Grading and Interpretation of Results on 96 Chemical Compounds, C. P. Carpenter, et al., J. Ind. Hyg. Toxicol., 31:343-346 (1949). Bio-Fax Data Sheets, Industrial Bio-Test Laboratories, Inc., 1810 Frontage Road, Northbrook, Illinois 60062. (Data on oral, dermal, inhalation toxicity, dermal and eye irritation, subacute oral toxicity of individual commodity chemicals-irregular issue.) Use with caution: Registry of Toxic Effects of Chemical Substances (formerly The Toxicty Substances List) ~E^ J. Fairchild, et al., eds. National Institute ^or_ Occupational Safety and Health, U.S. Department HEW. Available as annual printed edition or quarterly microfiche from U.S. Government Printing Office, Washington, D. C., 20402y also available online from National Library of Medicine. B. Testing in Progress Chemicals Being Tested for Carcinogenicity by the Carcinogenesis Testing Program^ National Cancer Institute, Division of Cancer Cause and Prevention, Bethesda, MD. Monthly. information Bulletin on the Survey of Chemicals Being Tested for Carcinogenicity, No. 7, Ghess, M. J. et al., comp. World Health Organization, International Agency for Research on Cancer, Lyon, France (1978). *Tox-Tips, Toxicology Information Program, National Library of Medicine, Bethesda, MD. Monthly. Toxicology Research Projects Directory, Toxicology Information Subcommittee, DHEW Committee to Coordinate Toxicology and Related Programs, NTIS. Monthly. 300046/7 SAL ^ 18 VIII. MISCELLANEOUS GUIDES TO TOXICITY AND SAFE HANDLING OF CHEMICALS Hygienic Guides. American Industrial Hygeine Association, 66 South Miller Road, Akron, Ohio 44313, Contents: Significant physical properties? hygienic standards; toxic properties industrial hygiene practice; medical information? references. (Also puhlished in AIHA J.) Chemical Safety Data Sheets. Manufacturing Chemists' Association, 1825 Connecticut Avenue, Washington, D. C. 20009, Contents: properties; health, fire, explosion, reactivity hazards; engineering control of hazards; employee safety? fire fighting; shipping, labeling, handling and storage? tank equipment cleaning and repairs; waste disposal? medical management? first aid. Industrial Safety Data Sheets. National Safety Council, 425 N. Michigan Ave . , Chicago, 111. 60611. Contents: properties; uses? container labeling? shipping regulations? storage; personal protective equipment; ventilation? fire and explosion hazards? symptoms of poisoning; first aid? treat ment? threshold limit values; waste disposal; references. API Toxicological Reviews. American Petroleum Institute, 1801 K Street, N.W., Washington, D. C. 20006. Contents: properties; uses and probable sources of contact? toxicity; precautions? treatment; references. SA1 19 VIII. MISCELLANEOUS GUIDES TO TOXICITY AND SAFE HANDLING OF CHEMICALS Hygienic Guides. American Industrial Hygeine Association, 66 South Miller Road, Akron, Ohio 44313, Contents: Significant physical properties; hygienic standards; toxic properties industrial hygiene practice; medical information; references. (Also published in AIHA J.) Chemical Safety Data Sheets. Manufacturing Chemists* Association, 1825 Connecticut Avenue, Washington, D. C. 20009, Contents: properties; health, fire, explosion, reactivity hazards; engineering control of hazards; employee safety; fire fighting; shipping, labeling, handling and storage; tank equipment cleaning and repairs; waste disposal; medical management; first aid. Industrial Safety Data Sheets. National Safety Council, 425 N. Michigan Ave., Chicago, 111. 60611. Contents: properties; uses; container labeling; shipping regulations; storage; personal protective equipment; ventilation; fire and explosion hazards; symptoms of poisoning; first aid; treat ment; threshold limit values; waste disposal; references. API Toxicological Reviews. American Petroleum Institute, 1801 K Street, N.W. , Washing-ton, D. C. 20006. Contents: properties; uses and probable sources of contact; toxicity; precautions; treatment; references. 19 IX. INDUSTRIAL HYGIENE A. Air Standards TLV^s Threshold Limit Values for Chemical Substances and Physical Agents in the Workroom Environment with Intended Changes for 1971T, American-Conference of Governmental Industrial HygTenists, P.0. Box 1937, Cincinnati, Ohio 45201. Documentation of Threshold Limit Values for Substances in Workroom Air and Supplemental Documentation, ACGIH, P.O. Box 1937, Cincinnati, Ohio 45201. American National Standards - Acceptable Concentrations, ANSI Z.37 Committee, American National Standards institute, T430 Broadway, N.Y. 10018. Criteria Documents, National Institute for Occupational Safety and Health, Public Health Service, U.S. Dept. HEW. Available from Superintendent of Documents, U.S Government Printing Office, Washington, D. C. 20402 and National Technical Information Office Service, 5285 Port Royal Road, Springfield, VA 22151. Occupational Exposure Limits for Airborne Toxic Substances, International Labour Office, Geneva (1977). Emergency Exposure Limits, National Research Council Committee on Toxicology, National Academy of Sciences, Washington, D. C. (1964). Documentation of MAC in Czechoslovakia, Czechoslovakia Committee of MAC, Praha (1969). Documentation of West German MAK's (Gesundheitsschadliche Arbeitsstoffe, Toxikologisch-arbeitsmedizinische Begriindung von MAK-Werten) Verlag Chemie, Weinheim, W. Germany (19^8). In German. Short Term Limits for Exposure to Airborne Contaminants A Documenta tion^ Pennsylvania Department of Health Division of Occupational Health, P.O. Box 90, Harrisburg, PA 17120. 000046/94 20 bn> IX. INDUSTRIAL HYGIENE (CONT'D) B. Background for Standard Development Stokinger, H. E., Modus Operand! of Threshold Limits Committee of ACGIHAm. Ind. Hyg. Assn. J., 25:589 (1964). Stokinger, H. E., Principles and Procedures for Developing Experimental Animal Data for Threshold Limit Values for Air, ACGIH, Threshold Limits Committee, 1914 Broadway, Cincinnati, Ohio 45202 (1975). Stokinger, H. E., Industrial Contribution to Threshold Limit Values, Arch. Environ. Health, 10:609 (1965). Stokinger, H. E., Current Problems of Setting Occupational Exposure Standards, Arch. Environ. Health, 19.-277 (1969). Stokinger, H. E., Toxicity of Air-borne Chemicals; Air Quality Standards - A National and International View, Ann. Rev. Pharm., 12:407 (1972). Brief, R. S. and R. A. Scala, Occupational Exposure_Limits for Novel Work Schedules, Am. Ind. Hyg. Assoc. J., 36:467 (1975). Methods Used in the USSR for Establishing Biologically Safe Levels of Toxic Substances, World Health Organization, Geneva (1975). Dinman, B. D., Development of Workplace Environment Standards in Foreign Countries, J. Occ. Med., 18:Part 1(409), Part 2(477) Part 3(556) , (1976) . C. Air Monitoring, Sampling, and Analysis Air Sampling Instruments for Evaluation of Atmospheric Contaminants, 4th Ed. Committee on Air Sampling Instruments, American Conference of Governmental Industrial Hygienists, 1014 Broadway, Cincinnati, Ohio 45202 (1972) . Analytical Guides, American Industrial Hygiene Association, 66~.South Miller Road, Akron, Ohio 44313 (also published in AIHA Journal). 0 o o'J O'* 679 21 IX. INDUSTRIAL HYGIENE (CONT'D) C. Air Monitoring, Sampling, and Analysis (Cont'd) ASTM Standards with Related Material, American Society for Testing and Materials, 1916 Race Street, Philadelphia, PA 19103 (issued annually). Brenchley, L. et al.. Industrial Source Sampling, Science Publishers, Inc., Ann Arbor, Michigan (1974). *Brief,Richard, Basic Industrial Hygiene Manual, Industrial Hygiene Association, Exxon Corporation (1975) . Calibration in Air Monitoring, American Society for Testing Materials, Philadelphia, PA 19103. Chapman, R. L., Environmental Pollution Instrumentation, Instrument Society of America ^Pittsburgh, PA 15219 (1969) . Chromatography of Environmental Hazards, Vol. 1, (Carcinogens, Mutagens, and Teratogens) Vol. 2~, TMetals, Gaseous and Industrial Pollutants). Lawrence Fishbein, Elsevier (1973). Drinker, P. and T. Hatch, Industrial Dust: Hygienic Significance, Measurement, and Control, 2ncT ed. McGraw-Hi ll^ N.Y . (1954) . Devorkin, H. et al., Air Pollution Source Testing Manual, Air Poll Control District, Los Angeles, Calif. (19T2) . Handbook of Clinical Laboratory Data, 2nd ed. Chemical Rubber Co., 18 9 01 Cranwood Parkway, Cleveland, Ohio 44128. Hanson, N. W. et al.. The Determination of Toxic Substances in Air. A Manual of ICI Practice, W. Heffer & Sons, Ltd., Cambridge, England (1965) . Industrial Ventilation. A Manual of Recommended Practice. American Conference of Governmental Industrial Hygienists (latest Ed.). Instrumentation for Environmental Monitoring - Air, Sponsored by Research Applied to National Needs, NSF, Lawrence Berkeley Laboratory, University of California, Berkeley. 000. 9^ 4, 'l-,7/ 9 6 22 IX. INDUSTRIAL HYGIENE (CONT'D) C. Air Monitoring, Sampling and Analysis (Cont'd) Journal of the Air Pollution Control Association, Cumulative Index, Subject and Author Vol. 1-22 (1^51-1972), Nichigai Associates, Inc. (1973). Katz, M., Measurement of Air Pollutants. Guide to Selection of Methods^ World Health Organization, Geneva, Switzerland (1969). Leith, W., The Analysis of Air Pollutants, Ann Arbor-Humphrey Science Publishers, Ann-Arbor, Michigan (1970). Linch, A. L., Biological Monitoring for Industrial Chemical Exposure, CRC Press, Inc., 18901 Cranwood Parkway, Cleveland, Ohio 44128 (1974). Linch, A. L., Evaluation of Ambient Air Quality by Personnel Monitoring, CRC Press, Inc., 18901 Cranwood Parkway, Cleveland, Ohio 44128 (1974). *Methods of Air Sampling and Analysis, 2nd ed., Intersociety Committee, American Public Health Association, Inc., 1015 Eighteenth Street, N.W. Washington, D. C. (1977). *NI0SH Manual of Analytical Methods, 2nd ed. Vol. I, II, III. U.S. Department HEW, NIOSH, 1014 Broadway, Cincinnati, Ohio 45202 (1977). NIOSH Manual of Sampling Data Sheets, U.S. Department HEW, NIOSH Cincinnati, Ohio 45202 (1977) NIOSH Publication No. 77-159. NIOSH Occupational Exposure Samplinq Strateqy Manual, U.S. Dept. HEW, NIOSH Publication No. 77-173. Olishifski, J. B. and McElroy, F. E., Fundamentals of Industrial Hygiene, National Safety Council, Chicago (1977) . Particle Size Analysis In Industrial Hygiene, American Industrial Hygiene Association and Atomic Energy Commission, Academic Press (1971). Principles for Evaluating Chemicals in the Environment, National Academy of Science, Washington, D"I C~. 0.975) . 23 (sOO 0*67 Sftl- IX. INDUSTRIAL HYGIENE (CONT fD) C. Air Monitoring, Sampling and Analysis (Cont'd) Ruch, W. E. , Quantitative Analysis of Gaseous Pollutants, Ann Arbor-Humphrey Science Publishers^,"Ann Arbor, Michigan (1970) . Sittig, M.f Pollution Detection and Monitoring Handbook, Noyer Data Corp., Park Ridge, N. J. (1974). D. Odor and Taste Thresholds Determination of Odor Thresholds for 53 Commercially Important Organic Compounds, Report presented-to Manufacturing Chemists Association, A. D. Little Co. (1968). Fazzalari, F. A., Compilations of Odor and Taste Threshold Values Data, American Society for Testinq Materials-, Philadelphia, PA 19103 (1978). Stern, A. C., Air Pollution, Vol. II, 2nd ed. Academic Press (1968). SAL 00004<! 24 X. FEDERAL REGULATIONS Code of Federal Regulations, Superintendent of Documents, U.S. Government' Printing Office, Washington, D. C. 20402 (revised annually). Sections applicable to toxicology and industrial hygiene: Title 16 CFR Part 1500 Commerical Products, Federal Hazardous Substances Act Part 1700 Poison Prevention Packaging Act Title 21 CFR Part 182 Food and Drugs, Substances Generally Recognized as Safe Title 29 CFR Part 1910 Labor, Occupational Safety and Health Standards Title 40 CFR Environmental Protection Agency, Toxic Substances Control Act (regulations are being published in several portions of this title, especially in the 700's) Title 42 CFR Part 85 Public Health, Requests for Health Hazard Evaluation Title 49 CFR Part 170-179 Transportation Part 172.101 Hazardous Materials Table Part 173.240 Corrosive Materials, Definition Part 173.326 Poison A Part 173.343 Poison B Federal Register, Superintendent of Documents, U.S. Government Printing Office, Washington, D. C. 20402. (Note: The Code of Federal Regulations is kept up-to-date by the individual issues of the Federal Register. These two publications must be used together to determine the latest version of any regulation). - 25 - S A L 0 0 0 0 4 6 7 9 '/ XI . NEWSLETTERS CURRENT AWARENESS CA Selects - Chemical Hazards, Carcinogens, Mutagens and Teratogens, Environmental Pollution; Pollution Monitoring Chemical Abstracts Service, Marketing Department P.0. Box 3012, Columbus, Ohio 43210. Biweekly (57 topics in all, several on analytical methods). Chemical Regulation Reporter, Bureau of National Affairs 1231 25th Street N. W. Washington, D. C. 20037. Weekly. Employment Safety and Health Guide, Commerce Clearing House 4025 W. Peterson Avenue, Chicago, 111. 60646. Weekly. Environment Reporter, Bureau of National Affairs, 1231 25th St. N.W. Washington, D. C. 20037. Weekly. The Food Chemical News Guide, Food Chemical News, Inc., 616 Warner Building, Washington, D. C. 20004. Industrial Hygiene News Report, Fluorney and Assoc., 1845 W. Morse", Chicago, 111-. 60621T. Monthly. Occupational Health and Safety Letter, G. W. Fishbein, Publisher, 1097 National Press Building, Washington, D. C. 20045. Semi-monthly. Occupational Safety and Health Reporter, Bureau of National ' Affairs, 1231 25th St. n7w~ Washington, D. C. 20037. Weekly. OHM Newsletter, Office of Hazardous Materials, U.S. Department of Transportation, Washington, D. C. 20590. Monthly. Pesticide and Toxic Chemical News, Food Chemical News, Inc. 420 Colorado Building, 1341G. Street N.W., Washington, D. C. 20005. Weekly. Toxic Materials News, Business Publication Inc., P.O. Box 1067 Silver~Spring, MD 20910. Weekly. SAL 000046800 26 XII. ONLINE COMPUTER DATA BASES A. Chemical Dictionary Files Chemline - National Library of Medicine, Bethesda, MD 20014 Chemname - Lockheed Missiles and Space Co., 3251 Hanover St., Palo Alto, CA 94304 Chemdex - Systems Development Corporation (SDC), 2500 Colorado Ave., Santa Monica, CA 90406 B. Bibliographic and Data Files Toxline - National Library of Medicine, Bethesda, MD 20014 Includes references to published information on toxicology, environmental effects of chemicals and pollutants, and analytical methods. Citations are taken from a variety of secondary sources: Chemical Abstracts, Abstracts on Health Effects of Environ mental Pollutants. Toxicity Bibliography, International Pharmaceutical Abstracts, Hayes File o`n Pesticides, Environmental Mutagen Information Center File, Toxic Materials Information Center File, Environmental Teratology Information Center File, and the Teratology File). Oil and Hazardous Materials - Technical Assistance Data System (OHM-TADS) - Informatics, Inc. 6000 Executive Blvd., Rockville, MD 20852. Supplied by EPA, the file contains toxicity data summaries on about 1000 substances, primarily as related to effects on water quality in the event of a spill. Registry of Toxic Effects of Chemical Substances (RTECS) National Library of Medicine (use data with caution). Cancerline - National Library of Medicine. Chemical Abstracts - Lockheed? (address above) Systems Development Corp.; (address above) or Bibliographic Retrieval Services, Inc., 1462 Erie Boulevard, Schenectady, N.Y. 12305. 'AL 0000468C):! 27 XII. ONLINE COMPUTER DATA BASES (CONT'D) B. Bibliographic and Data Files (cont'd) Biosis Previews - Lockheed, Systems Development Corp., or Bibliographic Retrieval Services, Inc., Contains Biological Abstracts and Bioresearch Index. Medline - National Library of Medicine and Bibliographic Retrieval Services Contains Index Medicus and other medically related information. Excerpta Medica - Lockheed. National Technical Information Service - Lockheed, Systems Development Corporation, or Bibliographic Retrieval Services. C. Other Files Cancerproj - National Library of Medicine. Contains project summaries of cancer-related research, including chemical carcinogenesis and cancer epidemiology. HAi 000046802 28 A__ X X X ___X___ x X RECEIVED. TOXICOLOGY DATA BANK UNIT RECORD DESCRIPTION JAM 18 1979 Note: The print options should be read down the column, l.e., STANDARD, EXCERPTS, INDEXSTR, VALUE, PHARMTOX, ENVIRON, MANUFACT, PHYSPROP, DETAILED. Search Tox. Data Bank Number CAS Registry Number Synonyms Name Fragments Molecular Formula Formula Fragments Wlswesser Line Notation Name of Substance (TDBN) (RN) (SY) (NF) (MF) (FF) (WL) (SY) PRINT OPTIONS 4^ PRINT 's M EA NN VU DR AP R TT U 0 TDB Number CAS Registry Number Synonyms Name Fragments Molecular Formula Mol. Formula Frag. Wlswesser Line Notation Name of Substance TDBN RN SY MF WL NM X XX -X X X X X X X X ExcerDt Terms* (EX) Animal Toxicity Excerpt Hunan Toxicity Excerpt Interaction Excerpt Laboratory Methods Excerpt EXS ATEX HTEX INEX LMEX f Index Strings* (IX) IXS Animal Toxicity Keywords ATKW Human Toxicity Keywords HTKW Interactants, CAS Nos. INCN Laboratory Methods Keywords LMKW Values (VALU). VALS Toxicity Values TO XV X X Minimum Fatal Dose MINF X X Maximum Dally Intake MXDI X X Threshold Limit Value TLIM X X Max. Dally Dose, Fatal XX Dose MAXF Note: "PRT EXS, MPRT IXS will print only the hit excerpts. Index strings when searched One must add COMPLETE to see all excerpts, or Index strings; or PRINT desired fields separately, l.e., "PRT NM, ATEX COMPLETE. T*r U000468Q `4. ' Search Elements Search Abbrev. Pharmacology/Toxlcology (PHTX) PRINT OPTIONS Elements Included PRINT Abbrev. SEI P MpD T X N H EA H E ACD ANNYT N E EV RVU SA DRXAMI FP I A PSL TRAR L RTTU 00C0 E DSR EX NTPD PHTS HbsffrpTlon, Distribution Excretion ADE Metabolism METB Poisoning Fbtentlal PPOT Antidote & Treatment ANTR Pharmacotherapy PHTH Therapeutic Uses THER Warnfngs/Cautlons WARN Idlosyncracles ID 10 . Therapeutic Index INDX Tolerance & Resistance TOLR Mechanism of Action ACTN XX XX XX XX XX XX XX XX XX XX XX Environmental Info. Manufacturing Data (ENVR) ENVS Envlron/Occup. Exp. & Limits Pollution fotentlal Fife fotentlal Explosive Limits Radiation Limits & Pot. Shipment Methods Disposal Methods EVLM POL P FPOT EXPL RADL SHIP DISP (fWNF) Not Directly Searchable Classification by Major Use Major Uses . Most Probable Method of Manuf. (U.S.) Manufacturing Info. Manufacturers Consumption Pattern U.S, Production U.S. Imports U.S. Exports MANS CMU USE MMA MMI MFS CPAT USP IMPT EXPT XX xX XX XX XX XX XX XX X X i <X X !X XX X 1X xX Xx xX 1 .r 4 : * J-j i -o i .3 3i ) 1 j* i * i 5. Search Elements Chemical-Ftysical Properties w~* - Search Abbrev. Elements Included PRINT OPTIONS PRINT Abbrev. S EI P MPD T X N H E A. H E A C D A N N Y TU EEVRVU SA DRXAMI FP I A PsLTRARL RT TU 00 C0 E DSRE XNTP0 PP Not Directly Search- able Boiling Point Col or/Form ' Density/Spec. Gravity Flash Point Melting Point Molecular Weight So 1 ub 111 ty Spectral & Other Prop. Stability/Shelf Life Vapor Pressure BP CF Den FP MP MW SOL SP SL VAP XX XX XX XX XX XX XX XX XX XX Status (Not searchable ) Status ST X X X X X X X X X j j > % S ! I Note: "PRT EXS, "PRT IXS will print only the hit excerpts, index strings when searched. One must add COMPLETE to see all excerpts, or Index strings; or PRINT desired fields separately, i.e., "PRT NM, ATEX COMPLETE. .1 I SAL <>00046BOS i