Document dQ3xkN8gopJqaxJQO5NbgGBBB

- h k M - 3AS.O DuPont-5990 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 2 of 5 Laboratory Project ID: DuPont-5990 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100(1998) A uthor: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study C ompleted o n: January 18,2002 Performing L aboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Page 337 of 1408 Company Sanitized. Does not contain TSCA CBI )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) Company Sanitized. Does not contain TSCA C8I LESIONS LESIOIJ INCIDIINCE (NIJMERIC) -- Fern;les TREATMENT 0. 25 100 500 (mg/kg/day) II IV VI Vili DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, INDIVIDUAL CELL. INFLAMMATION, SUBACUTE/CHRONIC, FOCAL. HYPERTROPHY, CENTRILOBULAR. (10) (10) (10) (10) 646537 646502 646608 646538 646522 646560 646567 646612 646576 646665 646595 646621 646635 646660 646664 646673 646610 646669 646617 646610 646649 646669 646676 646501 646509 646505 646535 646510 646536 646534 646577 646556 646593 646578 646609 646624 646610 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -338- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II VI VIII DIGESTIVE SYSTEM LIVER HYPERTROPHY, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. (10) 646592 646659 (10) (10) (10) 646629 646614 646633 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -339- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM , TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII PANCREAS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC, FOCAL. (10) 646537 646538 646560 646612 646617 646649 646659 646665 646676 646592 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -340- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) o 1 II 25 100 500 IV VI VIII ESOPHAGUS NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -341- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) o , 1H 25 100 500 IV VI VIII STOMACH NO ABNORMALITY DETECTED EROSION/ULCER, ACUTE. (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -342- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII DUODENUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -343- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM. | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII JEJUNUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -344- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -345- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) Females 1 H O1 H1 1 1 1 TREATMENT (mg/kg/day) 25 100 500 IV VI VIII DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -346- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -347- >) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) ' Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -348- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT 0 25 100 500 (mg/kg/day) 1 II IV VI VIII SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -349- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. INFLAMMATION, LYMPHOID, CORTICAL. (10) (10) (10) (10) 646537 646522 646534 646535 646538 646576 646578 646577 646560 646621 646608 646593 646592 646635 646629 646609 646649 646660 646633 646669 646659 646664 646665 646673 646676 646612 646567 646501 646509 646617 646595 646505 646536 646510 646610 646556 646614 646624 646657 646502 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -350- >) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS URINARY SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females o 25 100 500 II IV VI VIII URINARY BLADDER NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -351- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS RESPIRATORY SYSTEM 1 TREATMENT 1 (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII LUNGS NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -352- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS RESPIRATORY SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII TRACHEA NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -353- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS RESPIRATORY SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII PHARYNX/LARYNX NO ABNORMALITY DETECTED (10) 64653? 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -354- 1H 1O H Company Sanitized. Does not contain TSCA CBI )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) j Females TREATMENT (mg/kg/day) 25 100 500 IV VI VIII RESPIRATORY SYSTEM NOSE I & II NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified - 355- 1 !H 11 O H Company Sanitized. Does not contain TSCA CBI )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 25 100 500 IV VI VIII RESPIRATORY SYSTEM NOSE III & IV NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -356- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -357- 1 ( 1 H 1O Hi Company Sanitized. Does not contain TSCA C8I )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 25 100 500 IV VI VIII CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -358- )) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII SPLEEN NO ABNORMALITY DETECTED PIGMENT INCREASED. HEMATOPOIESIS, INCREASED. (10) (10) (10) (10) 646537 646502 646534 646538 646522 646578 646560 646567 646608 646592 646576 646629 646612 646595 646617 646635 646659 646660 646665 646664 646676 646673 646649 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 646621 646501 646536 646505 646577 646510 646593 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -359- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII SPLEEN HEMATOPOIESIS, INCREASED. (10) (10) (10) GO) 646556 646609 646624 646610 646633 646614 646657 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -360- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) Females TREATMENT 0 25 100 500 (mg/kg/day) II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -361- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED CONGESTION. (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646536 646577 646593 646609 646610 646614 646657 646669 646535 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -362- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -363- I! H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 TREATMENT 1 (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII BONE MARROW NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -364- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) o 1 II 25 100 500 IV VI VIII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED NO MICROSCOPIC EVIDENCE OF MACROSCOPIC FINDING. (10) (1) 646537 646567 646538 646560 646592 646612 646617 646649 646659 646665 646676 646567 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -365- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) 11 1H O 1H 1 LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 25 100 500 IV VI VIII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. (10) GO) (10) (10) 646538 646502 646560 646567 646592 646595 646612 646621 646617 646659 646665 646556 646509 646629 646535 646577 646593 646609 646610 646614 646657 646669 646537 646522 646501 646509 646649 646576 646505 646535 646676 646635 646510 646536 646660 646534 646577 646664 646556 646593 646673 646578 646609 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -366- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. (10) (10) (10) (10) 646608 646610 646624 646614 646629 646657 646633 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C8I -367- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 x, IV VI VIII ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED (8) 646537 646538 646612 646617 646649 646659 646665 646676 (9) 646509 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -368- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | TREATMENT | (mg/kg/day) i H H 11i111O LESION INCIDENCE (NUMERIC) Females 25 100 500 IV VI VIII ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED ( 10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 ( 10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -369- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females o 25 100 500 II IV VI VIII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -370- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS NERVOUS SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII SPINAL CORD NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -371- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) o 1 II 25 100 500 IV VI VIII (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -372- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 25 1 0 0 500 IV VI VIII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO A B N O R M A L I T Y D E T E C T E D (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H OM Company Sanitized. Does not contain TSCA CBI -373- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM 'H O i H1 | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 25 100 500 IV VI VIII FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 GO) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -374- 9H0--2D47ay68G: avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII STERNUM NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -375- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS REPRODUCTIVE SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT 0 25 100 500 (mg/kg/dayi 1 II IV VI VIII OVARIES NO ABNORMALITY DETECTED (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -376- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED DILATATION, LUMEN. (10) 646538 646560 646592 646612 646617 646649 646659 646665 646676 646537 (1) (10) 646509 646535 646536 646593 646610 646614 646669 646505 646577 646609 646657 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -377- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII REPRODUCTIVE SYSTEM MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED HYPERPLASIA, LOBULAR. (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (1) (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 646556 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -378- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS CUTANEOUS SYSTEM LESION INCIDENCE (NUMERIC) Females TREATMENT o 25 100 500 (mg/kg/day) 1 II IV VI VIII SKIN NO ABNORMALITY DETECTED ALOPECIA/HYPOTRICHOSIS. (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646535 646536 646577 646593 646609 646610 646614 646657 646669 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -379- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION) LESIONS | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII SPECIAL SENSES SYSTEM EYE(S ) WITH OPTIC NERVE NO ABNORMALITY DETECTED HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE) . (10) 646537 646538 646560 646592 646612 646617 646649 646659 646665 646676 (10) 646509 646536 646577 646593 646609 646610 646614 646657 646669 646535 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -380- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM |LESION INCIDENCE (NUMERIC) Females | TREATMENT | (mg/kg/day) 1 0 II 500 VIII LIVER NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC, FOCAL. HYPERTROPHY, CENTRILOBULAR. (10) (10) 646511 646506 646549 646508 646551 646540 646580 646542 646581 646545 646586 646548 646613 646599 646627 646637 646652 646650 646565 646618 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -381- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM |LESION INCIDENCE (NUMERIC) Females 1 TREATMENT 1 (mg/kg/day) 1 0 II 500 VIII STOMACH EROSION/ULCER, ACUTE. (1) 646637 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -382- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS |LESION INCIDE|N--C--E------(--N--U--M--E--R--I--C-)-- I Females TREATMENT (mg/kg/day) 0 II 500 VIII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. HYDRONEPHROSIS, UNILATERAL. ( 10) ( 10) 646511 646637 646551 646650 646565 646580 646586 646613 646627 646652 646549 646506 646508 646540 646542 646545 646548 646599 646618 646581 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -383- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS |LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) 0 II 500 VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED HEMATOPOIESIS, INCREASED. (10) (10) 646511 646506 646549 646508 646551 646540 646565 646542 646580 646548 646581 646599 646586 646618 646613 646637 646627 646650 646652 646545 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -384- )) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS |LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) 0 II 500 VIII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) ( 10) 646511 646549 646551 646565 646580 646581 646586 646613 646652 646508 646540 646542 646548 646618 646637 646627 646506 646508 646540 646542 646545 646548 646599 Company Sanitized. Does not contain TSCA CBI -385- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM |LESION INCIDENCE (NUMERIC) Females TREATMENT (mg/kg/day) 0 II 500 VIII THYROID GLAND ALTERATION, COLLOID. (10) (10) 646618 646637 646650 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -386- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC, FOCAL. HYPERPLASIA, BILIARY. FATTY CHANGE, MEDIAN CLEFT. (4) (5) (5) (5) 646530 646531 646533 646528 646588 646568 646630 646601 646625 646632 646667 646626 646634 646636 646656 646523 646507 646597 646620 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -387- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED PYELONEPHRITIS, UNILATERAL. NEPHROPATHY, CHRONIC PROGRESSIVE. (4) (5) (5) (5) 646507 646531 646533 646620 646530 646626 646636 646597 646588 646568 646630 646523 646597 646625 646632 646528 646634 646601 646656 646667 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -388- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII SPLEEN NO ABNORMALITY DETECTED PIGMENT INCREASED. (4) (5) (5) (5) 646507 646531 646632 646523 646530 646568 646634 646528 646588 646625 646656 646620 646597 646626 646636 646533 646601 646630 646667 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -389- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED - NEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII THYROID GLAND NO ABNORMALITY DETECTED ALTERATION, COLLOID. (4) (5) (4) (4) 646507 646531 646620 646530 646626 646588 646597 646568 646630 646523 646625 646632 646528 646636 646634 646667 646656 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -390- H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations TABLE 46 MICROSCOPIC LISTING OF CAUSE OF DEATH IN MALE RATS (90-DAY EXPOSURE, 1-MONTH RECOVERY, AND 3-MONTH RECOVERY EVALUATIONS) DuPont-5990 LESIONS LESION INCIDENCE (Animal #) Males TREATMENT (mg/kg/day) 0 I 25 100 500 III V VII CAUSE OF DEATH SACRIFICE BY DESIGN. EYE: HEMORRHAGE/INFLAMMATION (BLEEDING PROCEDURE). KIDNEY: INFLAMMATION/OBSTRUCTION. (25) 24 1 (15) 15 (15) 14 1 (27) 25 2 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -391- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 47 FOR 90-MDIACYROESXCPOOPSIUCRLEISATNINDG1-OMFOCNATUHSEANODF D3-EMAOTNHTIHNRFEECMOAVLEERRYAATNSIMALS ) DuPont-5990 LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) Females 0 25 100 500 II IV VI VIII CAUSE OF DEATH SACRIFICE BY DESIGN. (24) 24 (15) 15 (15) 15 (25) 25 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI -392- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 48 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF P, MALE RATS GROUP DOSE (mg/kg/day) N TEST DAY 77 84 91 98 1-0 III-O V-0 VII-0 0 25 100 500 20 20 20 18 MEAN BODY WEIGHT (grams ) 552.9(59.7)3 568.7(61.9) 580.1(66.8) 593.7(66.9) 560.6(53.6) 570.9(59.0) 587.3(62.5) 605.5(64.9) 517.5(31.5)* 530.8 (30.3) * 543.5 (31.1)* 557.3 (30.3)* 462.3(49.6) 472.4(52.3) 482.7(50.6) 490.0(57.9) GROUP 1-0 III-O V-0 VII-0 DOSE (mg/kg/day) N 0 20 25 100 500 20 20 18 TEST DAYS MEAN BODY WEIGHT GAIN (grams) 77-84 84-91 91-98 15.8(8.3)3 11.4(12.8) 13.7(6.9) 10.3(12.1) 16.4(9.9) 18.3(6.5) 13.3(8.7) 12.7(6.4) 13.8(6.4) 10.1(7.7) 10.3(6.0) 7.4(21.1) 77-98 40.8(15.2) 44.9(14.5) 39.8(16.3) a Standard deviation is reported in parentheses. 27.8(22.4) * Statistically significant difference from control by Jonckheere-Terpstra test (p < 0.05). -393- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 49 MEAN BOOFDPY, WFEEMIGAHLTESRAANTDS MDUERAINNGBOGDEYSTWAETIIGOHNT GAINS GROUP DOSE (mg/kg/day) N GESTATION DAY 0 7 14 21 II-O 0 16 IV-0 25 11 VI-0 100 11 VIII-0 500 12 309.5(30.5)a 343.2(25.9) 377.9(27.2) 466.3(29.0) MEAN BODY WEIGHT (grams) 299.2(14.5) 332.1(20.3) 363.9(20.8) 445.3(32.4) 291.2(11.6) 325.1(20.1)* 356.4(18.9)* 444.8(35.0) 284.1(25.7)* 310.3(26.8)* 336.8(32.5)* 396.8(53.1)* GROUP DOSE (mg/kg/day) N II-O 0 16 IV-0 25 11 VI-0 100 11 VIII-0 500 12 GESTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 33.7(12.1)3 34.7(4.8) 88.5(17.0) 33.0(8.2) 31.8(7.8)* 81.4(16.0) 33.9(12.1) 31.3(10.1)* 88.4(21.0) 26.2(10.3)* 26.5(11.7)* 60.0(24.3)* 0-21 156.8(24.4) 146.1(24.3) 153.6(27.8) a Standard deviation is reported in parentheses. 112.7(37.7)* * Statistically significant difference from control by Jonckheere-Terpstra test (p < 0.05). -394- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 50 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N LACTATION DAY II-O 0 17 IV-0 25 11 VI-0 100 11 MEAN BODY WEIGHT (grams) VIII-0 500 12 0 349.1(24.1)*,b 344.0(29.4)3 328.3(19.7)* 311.3(34.7)* 7 359.6(24.3) 353.7(23.0) 347.9(17.6) 326.0(29.6)d* 14 380.1(23.5) 364.7(18.2) 354.9(22.2)3* 330.4(11.3)3* 21 352.9(27.8) 342.1(27.1) 350.1(16.3)c 333.7(15.0)3 GROUP DOSE (mg/kg/day) N II-O 0 17 IV-0 25 11 VI-0 100 11 VIII-0 500 12 LACTATION DAYS MEAN BODY WEIGHT GAIN (grams ) 0-7 7-14 14-21 10.6(12.8)3,b 20.6(9.5) -27.2(17.5) 12.1(11.9)3 11.0(13.0)* -22.6(25.9) 19.6(17.6) 9.4(15.2)3* -4.8(24.5)3* 17.7(13.6)d -0.3(20.5)3* 3.3 (3.7) e* 0-21 3.9 (20.0 )b -0.2(34.0)3 25.7 (23.4)3 a Standard deviation is reported in parentheses, b N = 16. c N = 10. d N = 11. e N = 3. 30.5(14.0)s* * Statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). -395- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 51 MEAN DAILYOFFOPO, DFECMOANLSEURMAPTTSIODNUARNINDGMGEEASNTAFTOIOODN EFFICIENCY GROUP DOSE (mg/kg/day) N GESTATION DAYS II-O 0 16 IV-0 25 11 VI-0 100 11 VIII-0 500 12 MEAN DAILY FOOD CONSUMPTION (grams)1 0-7 7-14 14-21 25.2(2.3)a 27.2(2.9) 27.3(3.5) 24.0(5.5) 27.5(3.9) 27.8(2.7) 24.5(3.1) 26.3(2.7) 27.9(7.6) 23.4(3.3) 26.6(3.7) 27.7(5.0) 0-21 26.6(2.0) 26.4(3.2) 26.3(3.9) a Standard deviation is reported in parentheses. 25.9(3.5) There was no statistically significant trend in food consumption by Jonckheere-Terpstra test (p < 0.05). GROUP DOSE (mg/kg/day) N II-O 0 16 IV-0 25 11 VI-0 100 11 VIII-0 500 12 GESTATION DAYS MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) 0-7 7-14 14-21 0.188 (.066)a 0.183(.022) 0.473(.122) 0.210(.089) 0.166(.036) 0.420(.076) 0.194(.050) 0.170(.050) 0.559(.504) 0.158(.053) 0.140(.061) 0 . 31K .149) 0-21 0.282(.042) 0.266 (.047) 0.282(.057) a Standard deviation is reported in parentheses. 0.206(.066) * Statistically significant difference from control in food efficiency by One-Way Analysis of Variance (p < 0.05). -396- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 52 SUMMARY OF CLINICAL OBSERVATIONS IN Pi RATS DuPont-5990 Pi MALE RATS GROUP DOSE (mg/kg/day) N Number of Rats with Observation 1-0 III-O V-0 VII-0 0 25 100 500 20 20 20 18 OBSERVATIONS Alopecia Discharge Eye(s) Discharge Mouth Discharge Nose Salivation Stained Fura Stained Right Eye(s) 113 3 1 000 1000 1000 0 5* 15* 14* 0 0 0 4* 1000 Total No. of Rats with Masses 000 a Includes stained perineum and stained inguen. * Statistically significant trend by Cochran-Armitage test; p < 0.05. 0 -397- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 52 (CONTINUED) SUMMARY OF CLINICAL OBSERVATIONS IN Pi RATS DuPont-5990 Pi FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N OBSERVATIONS Alopecia Colored Discharge Vaginal Opening Discharge Left Eye(s) Salivation Stained Cageboard Stained Perineum Stained Vaginal Opening Number of Rats with Observation II-O IV-0 VI-0 VIII-0 0 25 100 500 19 20 19 20 3637 0001 1000 0 0 9* 7* 0001 0 2 1 5* 0001 Total No. of Rats with Masses 0000 Note: This table includes clinical observations from animals with copulation plugs observed. Pj. FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N OBSERVATIONS Alopecia Colored Discharge Vaginal Opening Discharge Left Eye(s) Salivation Stained Left Eye(s) Stained Perineum Number of Rats with Given Sign II-O IV-0 VI-0 VIII-0 0 25 100 500 17 11 11 12 2434 0001 1000 0010 1000 0 0 0 2* Total No. of Rats with Masses 010 Site: Mass 1 First Observed (2.0 cm) 0 1 0 Shoulder * Statistically significant trend by Cochran-Armitage test; p < 0.05. 0 0 -398- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 53 MEAN ESTROUS CYCLEIPNAPR, AFMEMETAELRESRAANTSD PRECOITAL INTERVAL Percent Percent Percent of Days of Days of Days Mean Cycle Dose in in in Length Group (mg/kg/day) N Estrus Diestrus Proestrus (days) Mean Precoital Interval (days) II-O 0 19 32 60 7 4.3(0.47)a,b 3.4(3.37) IV-0 25 20 31 59 10 4.7{0.69)c* 3.3(3.30) VI-0 100 20 34 60 6 4.9(1.12)c* 2.8(2.78)C? VIII-0 500 19 29 60 10 a Standard deviation is presented in parentheses. b N = 16. c N = 18. d N = 19. 4.8(0.56)c * 3.1(3.05) * Statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). -399- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 54 SUMMARY OF SPERM PARAMETERS IN P, MALE RATS DuPont-5990 Group Dose (mg/kg/day) 1-0 0 III-O 25 V-0 100 VII-0 500 MOTILITY Percent Motile Standard Deviation 92.8 5.6(10)a 91.7 5.0(10) 93.4 3.8(10) 91.1 3.9(10) MORPHOLOGY Percent Normal Standard Deviation 98.3 0.5(10) 98.3 1.5(10) 98.9 0.6(10) 97.7 2.1(10) EPIDIDYMAL SPERM (Millions) Per Cauda 318.4 Standard Deviation 32.6(10) 278.8* 17.5(10) 291.1* 28.2(10) 279.4* 21.7(10) Per gram Cauda Standard Deviation 1180.2 93.3(10) 979.2 136.9(10) 969.0 100.2(10) 1062.1 153.1(10) TESTICULAR SPERMATIDS (Millions) Per Testis 126.5 Standard Deviation 9.4(10) 128.8 8.6(10) 128.2 9.9(10) 137.0* 9.9(10) Per gram Testis Standard Deviation 83.3 4.3(10) a Number in group is in parentheses. 93.7 13.5(10) 87.4 11.7(10) 83.4 9.8(10) * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. -400- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 55 SUMMARY OF REPRODUCTIVE INDICES: P, GENERATION MATERNAL GROUP DOSE (mg/kg/day) II-O 0 IV-0 25 VI-0 100 VIII-0 500 MATING INDEX (%) (No. copulated/cohoused) 100.0 (20/20) 100.0 (20/20) 95.0 (19/20) 100.0 (20/20) FERTILITY INDEX (%) (No. delivered/copulated) 85.0 (17/20) 55.0 (11/20) 57.9 (11/19) 65.0 (13/20) GESTATION LENGTH (days) (No. in group) 22.6 (16) 22.4 (ID 22.5 (11) 22.9 (12) NUMBER OF IMPLANTATION SITES per pregnant female Standard Deviation(No.in group) 15.3 2.49(17) 14.1 3.75(11) 14.8 10.7* 3.37(11) 4.48(14) IMPLANTATION EFFICIENCY (%)a Standard Deviation(No.in group) 90.0 7.71(14) 93.2 5.01(10) 88.6 7.90(10) a Number of pups born/number of implantation sites X 100. 86.0 17.79(12) There were no statistically significant trends in mating or fertility indices by Cochran-Armitage test; p < 0.05. There was no statistically significant difference from control in gestation length or implantation efficiency by Jonckheere-Terpstra test; p < 0.05. * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. -401- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 56 MEAN PUP NUMBERS AND SURVIVAL: F, GENERATION MATERNAL GROUP DOSE (mg/kg/day) N II-0 0 17 IV-0 25 11 VI-0 100 11 VIII-0 500 13 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 D a y 14 Day 21 MEAN NUMBER OF PUPS/LITTER 14.33 14.3a 14.1 8.0 8.0 8.0 8.0 13.7b 13.5b 12.8 7.9 7.9 7.9 7.9 13.4 13.1 12.9 8.0 7.7 6.3* 6.1* 10.3* 9.4* 7.5* 6.3* 4.8* 1.1* 0.8* Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 D a y 14 D a y 21 MEAN NUMBER OF MALE PUPS/LITTER 6 .9a 6 .9a 6.8 3.8 3.8 3.8 3.8 7.8b 7.8b 7 .4 4.1 4.1 4.1 4.1 6.6 6.5 6.5 4.1 4.0 3.4 3.4 4.9 4.5 3.8 3.2 2.5 0.5 0.4 Born Born Alive Day 4 Preculling Day 4 Postculling MEAN NUMBER OF FEMALE PUPS/LITTER 7.3a 5.9b 7 .3a 5.7b 7.2 5.5 4.2 3.8 6.7 6.5 6.4 3.9 5.3 4.8 3.6 3.1 Day 7 4.2 3.8 3.7 2.4 D a y 14 4.2 3.8 2.9 0.5 D a y 21 4.2 3.8 2.7 0.4 SURVIVAL (%) Sex Ratio (males) 0.48a 0.58b 0.50 0.46 Gestation Index0 Mean % Born Alive 0-4 Day Viability 100.0 1 0 0 . oa 97.6a 100.0 98.8b 98.5b 100.0 98.1 98.9 92.3 86.7* 82.8d Lactation lndexe Litter Survivals' 100.0 100.0 98.2 100.0 76.1* 90.9 11.4f* 25.0** a N = 16. b N = 10. c Percent litters delivered having at least one live pup. d N = 12. e M e a n perc e n t survival from Da y 4 Postcu l l i n g to Da y 21. f N = 11. g Percent litters b o r n w i t h at least one p u p al i v e on D a y 21. * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. ** S t a t i s t i c a l l y signif i c a n t trend b y C o c h r a n - A r m i t a g e test; p < 0.05. Statistics were performed on combined pups per litter only. Male and female data are presented for information only. -402- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 57 MEAN PUP WEIGHTS: Fi GENERATION DuPont-5990 MATERNAL GROUP DOSE (mg/kg/day) N II-O 0 17 IV-0 25 11 VI-0 100 11 MEAN PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.9 (0.8)a 'b 11.5 (1.9) 11.5 (1.9) 18.4 (2.7) 38.0 (3.2) 62.6 (6.3) 6.8 (0.9)c 12.2 (2.1) 12.3 (2.1) 18.9 (2.4) 37.7 (3.3) 59.9 (6.0) 6.7 (0.5) 10.8 (1.5)* 10.8 (1.4)* 15.9 (3.1)* 35.7 (3 . 2 )c * 58.6 (7.5)c VIII-0 500 12 6.2 (0.4)* 8.2 (1.5)d* 8.2 (1.6)d* 9.9 (2.8)d* 21.3 (3.4)e* 35.9 (6.1 )e* MEAN MALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 7.2 ( 0 . S ) b 11.9 (2.0) 11.8 (2.0) 18.9 (2.8) 38.7 (3.2) 64.2 (6.1) 7.1 (1.0)f 12.5 (2.1) 12.6 (2.1) 19.4 (2.4) 38.6 (3.3) 61.9 (5.2) 6.9 (0.6) 11.0 (1.7) 11.1 (1.6) 16.3 (3.3) 37.0 (2.9)c 59.9 (8.2 )c 6.4 (0.4)d 8.4 (1.5)d 8.5 (1.6)d 10.3 (2.8 )c 23.4 (5.5)e 33.6 (5.5)e MEAN FEMALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.7 (0.7)i> 11.2 (1.9) 11.3 (1.9) 17.9 (2.7) 37.3 (3.2) 61.0 (6.3) 6.6 (0.9)f 11.8 (2.0) 11.9 (2.0) 18.4 (2.4) 36.7 (3.2) 57.8 (5.7) a Standard deviation is reported in parentheses. b N = 16. c N = 10. d N = 11. e N = 3. f N = 9. 6.5 (0.5) 10.5 (1.3) 10.5 (1.3) 15.4 (2.8) 34.3 (4.4) 58.9 (4.6)f 6.0 (0.4)d 8.0 <1.5)<* 8.0 (1.5)<3 9.9 (2.8)tf 21.5 (5.7 )e 30.3 (12.0)e * Statistically significant trends by linear contrast of least square means; p < 0.05. Note: Statistical analyses were conducted on the combined pup weights. Male and female data are presented for information only. -403- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 58 SUMMARY OF PUP CLINICAL OBSERVATIONS: Fi GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 25 VI-0 100 VIII-0 500 OBSERVATIONS LETHARGY PARTIALLY CANNIBALIZED STAINED PERINEUM WEAK WET PERINEUM 0001 1000 0001 0001 0001 TOTAL NUMBER OF SIGNS NUMBER OF LITTERS AFFECTED TOTAL NUMBER OF LITTERS 100 100 17 11 11 a Numbers outside the parentheses are the number of pups affected; the numbers in parentheses are the number of litters affected. 4 1 12 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. -404- Company Sanitized. Does not contain TSCA GBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 59 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Fi MALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 1-1 III-l V-l 0 25 100 17 11 10 MEAN BODY WEIGHT (grams) 64.4(6.7)* 109.2(9.6) 172.4(14.1) 239.9(17.6) 303.7(21.3) 364.7 (25.7) 61.6(5.6) 106.6(6.2) 169.7(10.8) 236.7(16.3) 300.8(21.2) 361.7(27.2) 61.1(6.1) 103.5(9.0) 163.0(17.1) 229.3(20.2) 291.9(26.2) 352.4(30.7) GROUP DOSE (mg/kg/day) N 1-1 0 17 III-l 25 11 V-l 100 10 DAYS ON TEST3 MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 15-22 22-29 29-36 44.7(4.4)* 63.2(5.1) 67.5(6.7) 63.8(5.9) 61.1(7.9) 45.0(4.4) 63.1(5.8) 67.0(6.0) 64.1(6.4) 60.9(7.7) 42.4(4.6) 59.5(11.0) 66.3(6.0) 62.6(6.7) 60.5(8.4) 1-36 300.3(22.5) 300.1(24.1) 291.3(25.5) a Day of Weaning = Test Day 1. * Standard deviation is reported in parentheses. There were no statistically significant trends by Jonckheere-Terpstra test (p < 0.05). -405- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 60 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Fi FEMALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 II-l 0 17 IV-1 25 11 VI-1 100 9 MEAN B0DY WEIGHT (grams) 61..0 (7. 0)> 101..9 (12 .7) 144,.4 (16 .7) 176..0 (17 .7) 199..7 (20 .8) 221..1 (21 .6) 57 ,.0 (9. 0) 94 .9 (11 .2) 139 .7 (14 .0) 176 .1 (12 .9) 202 .8 (13 .7) 220..8 (14 .9) 60 .9 (4. 6) 98 .9 (8. 6) 141..4 (9. 3) 176..8 (12 .3) 204..5 (16 8) 227 .3 (21 .4) GROUP DOSE (mg/kg/day) N II-l 0 17 IV-1 25 11 VI-1 100 9 DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 MEAN BODY WEIGHT GAIN (grams) 40.9 (7.3 )-b 42.6(5.7) 31.5(5.6) 23.7(7.7) 21.4(5.1) 38.0(9.8) 44.8(7.4) 36.3(6.0) 26.8(6.7) 18.0(5.4) 38.0(5.0) 42.5(6.3) 35.3(5.6) 27.7(6.9) 22.8(7.3) 1-36 160.1(17.6) 163.9(17.7) 166.4(20.3) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. There were no statistically significant trends by Jonckheere-Terpstra test (p < 0.05). -406- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 61 MEAN DAILY FOOD CONOSUFMF,PMTIAOLNEARNADTSMEAN FOOD EFFICIENCY GROUP DOSE (rog/kg/day) N DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 1-36 1-1 III-l V-l 0 25 100 17 11 10 MEAN DAILY FOOD CONSUMPTION (grams) 12.7(1.1) ' c 20.1(1.8) 26.0(2.2) 28.9(2.5) 32.5(4.2) 12.3(0.6)* 19.6(1.4) 25.0(2.1) 28.1(2.3) 30.8(3.1) 23.9 (2.0) c 23.1(1.8)* 11.9(1.4) 19.1(2.2) 25.3(3.0) 28.1(3.1) 31.2(3.1) 23.1(2.3) GROUP DOSE (mg/kg/day) N 1-1 0 17 III-l 25 11 V-l 100 10 DAYS ON TEST3 MEAN FOOD EFFICIENCY (grams weight gain/grams food. consumed) 1-8 8-15 15-22 22-29 29-36 0.501 (.035) -k'c 0.45K .026) 0.372 (.031) 0.316 (.025) 0.270( .026) 0.514 (.033)* 0.461(.036) 0.384 (.026) 0.326 (.028) 0.283( .023) 0.510(.031) 0.443(.052) 0.376(.031) 0.319(.020) 0.279(.035) 1-36 0.360( .019)c 0.371 (.019)* 0.361( .019) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. c N = 16. d N = 10. There were no statistically significant trends by Jonckheere-Terpstra test (p < 0.05). -407- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 TABLE 62 MEAN DAILY FOOD COONSFUFMi FPETMIOANLEANRDATMSEAN FOOD EFFICIENCY GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 1-36 II-l 0 17 IV-1 25 11 VI-1 100 9 MEAN DAILY FOOD CONSUMPTION (grams) 12.0 {1.7 )>'c 17.4(2.1) 19.4(1.7) 19.5(2.0) 20.4(2.6) 10.8(2.0)d 16.8(1.9) 19.2(1.9) 19.9(2.3) 20.1(2.7) 17.6(1.7)c 17.3(1.6)d 11.1(1.3) 16.7(1.2) 19.2(1.5) 19.8(2.4) 20.9(2.6) 17.5(1.6) GROUP DOSE (mg/kg/day) N II-l 0 17 IV-1 25 11 VI-1 100 9 DAYS ON TEST3 MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) 1-8 8-15 15-22 22-29 29-36 0.481 (. 050)-b' c 0.350(.035) 0.233(.037) 0.173(.050) 0 . 15K .036) 0.491(.078)d 0.381(.041) 0.271( .038) 0.191(.030) 0.127(.033) 0.489(.030) 0.363(.040) 0.262 (.029) 0.198(.030) 0.155(.041) 1-36 0.258(.019)c 0.268(.014)d 0.271(.012) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses, c N = 16. d N = 10. There were no statistically significant trends by Jonckheere-Terpstra test (p < 0.05). -408- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 63 SUMMARY OF CLINICAL OBSERVATIONS IN F, RATS DuPont-5990 Fi MALE RATS DOSE GROUP (mg/kg/day) N Number of Rats with Given Observation 1-1 III-l V-l 0 25 100 17 11 10 OBSERVATIONS Alopecia 101 Total No. of Rats with Masses 000 Fj. FEMALE RATS DOSE GROUP (mg/kg/day) N Number II-l 0 17 of Rats with Given Observation IV-1 VI-1 .25 100 11 9 OBSERVATIONS Alopecia 100 Total No. of Rats with Masses 000 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. -409- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 TABLE 64 SUMMARY OF DEVELOPMENTAL LANDMARKS IN F, RATS PREPUTIAL SEPARATION - Fj. MALE RATS GROUP DOSE (mg/kg/day) N 1-1 0 17 III-l 25 11 V-l 100 10 (Days)a 43.9 (1.7) 44 .8 (1. 7) 45 .3 (1. 8) VAGINAL OPENING - Fx FEMALE RATS GROUP DOSE (mg/kg/day) N II-l 0 17 IV-1 25 11 VI-1 100 9 (Days)a Data summarized as: 31.4 31.6 (2.3) (2.0) Mean Standard Deviation 31.6 (2.4) a Age was calculated as follows using data presented in Appendix X: Test day + 2 0 days = Age (days). There were no statistically significant trends by JonckheereTerpstra test; p < 0.05 -410- Company Sanitized. Does not contain TSCA CBI )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 65 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) GROUP DESIGNATION DOSE (MG/KG/DAY) 1-1 0 LIVER 19.10753 2.14545(17) BRAIN 1.96106 0.08687(17) THYROID GLAND 0.01412 0.00649(17) PROSTATE 0.47559 0.08548 (17) SEMINAL VESICLES 1.19841 0.24132(17) TESTES 3.13029 0.18046(17) EPIDIDYMIDES 0.75900 0.05354(17) FINAL BODY WEIGHT 395.92941 28.04273(17) III-l 25 18.29264 2.63240(11) 1.97909 0.06868(11) 0.01555 0.00537(11) 0.49618 0.10829(11) 1.11682 0.16474(11) 3.17909 0.18267(11) 0.74682 0.04630(11) 391.74545 29.71398(11) V-l 100 17.54510# 1.79217(10) 2.00640 0.07276(10) 0.01420 0.00571(10) 0.40550 0.09267(10) 1.11940 0.29708(10) 3.22740 0.30191(10) 0.75320 0.10057(10) 380.49000 31.86020(10) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -411- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 65 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - F, ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DESIGNATION DOSE (MG/KG/DAY) 1-1 0 LIVER/ FINAL BODY * 100 4.81751 0.30914(17) BRAIN/ FINAL BODY * 100 0.49657 0.02388(17) THYROID GLAND/ FINAL BODY * 100 0.00353 0.00153(17) PROSTATE/ FINAL BODY * 100 0.12045 0.02135(17) SEMINAL VESICLES/ FINAL BODY * 100 0.30259 0.05620(17) TESTES/ FINAL BODY * 100 0.79415 0.06965(17) EPIDIDYMIDES/ FINAL BODY * 100 0.19222 0.01488(17) III-l 25 4.65556 0.39361(11) 0.50754 0.03817(11) 0.00401 0.00157(11) 0.12768 0.03086(11) 0.28591 0.04314(11) 0.81470 0.06474(11) 0.19174 0.02011(11) V-l 100 4.61091# 0.27669(10) 0.52987# 0.03789(10) 0.00369 0.00135(10) 0.10749 0.02600 (10) 0.29484 0.07647(10) 0.85221 0.09391(10) 0.19750 0.01643(10) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -412- )) ) H90--2D47a6y8G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations___________________________________________________________ DuPont-5990 TABLE 65 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% organ to brain weight ratio) GROUP DESIGNATION DOSE (MG/KG/DAY) 1-1 III-l 0 25 LIVER/ BRAIN * 100 972.70394 83.97358(17) 923.79751 125.57847(11) THYROID GLAND/ BRAIN * 100 0.71997 0.32826(17) 0.78780 0.28352(11) PROSTATE/ BRAIN * 100 24.26966 4.28542(17) 25.03353 5.16410(11) SEMINAL VESICLES/ BRAIN * 100 61.17512 12.31264(17) 56.46962 8.44039 (11) TESTES/ BRAIN * 100 159.81799 10.01195(17) 160.59847 6.53677(11) EPIDIDYMIDES/ BRAIN * 100 38.71959 2.45678(17) 37.78911 2.93573(11) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. V-l 100 873.69136# 74.71051(10) 0.70876 0.28864(10) 20.18179 4.30040(10) 55.60431 13.57763 (10) 160.86235 13.96853(10) 37.51352 4.57538(10) Company Sanitized. Does not contain TSCA C8I -413- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 66 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - F, ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) GROUP DESIGNATION DOSE (MG/KG/DAY) II-l 0 LIVER 10.28012 1.13851(17) BRAIN 1.79000 0.07115(17) THYROID 0.01259 0.00533(17) UTERUS 0.45700 0.15994(17) FINAL BODY WEIGHT 231.67059 22.86460(17) IV-1 25 10.87673 1.22832(11) 1.83255 0.04639(11) 0.01160 0.00510(10) 0.42518 0.08647(11) 234.50909 16.78973(11) VI-1 100 10.75767 1.78708(9) 1.79978 0.04439(9) 0.01000 0.00527(9) 0.43378 0.10597(9) 238.24444 24.17835(9) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -414- ) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 66 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DESIGNATION DOSE (MG/KG/DAY) II-l 0 LIVER/ FINAL BODY * 100 4.43880 0.25399(17) BRAIN/ FINAL BODY * 100 0.77823 0.06576(17) THYROID GLAND/ FINAL BODY * 100 0.00542 0.00204(17) UTERUS/ FINAL BODY * 100 0.19900 0.07237(17) IV-1 25 4.63930 0.40473(11) 0.78540 0.06379(11) 0.00486 0.00206(10) 0.18143 0.03503(11) VI-1 100 4.49307 0.37135(9) 0.76104 0.06372 (9) 0.00418 0.00208(9) 0.18532 0.05515(9) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -415- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 66 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - F, ADULTS MEAN RELATIVE ORGAN WEIGHTS (% organ to brain weight ratio) GROUP DESIGNATION DOSE (MG/KG/DAY) II-l 0 IV-1 25 LIVER/ BRAIN * 100 574.30646 59.04790(17) 593.40709 63.73253 (11) THYROID GLAND/ BRAIN * 100 0.70673 0.30607(17) 0.63717 0.28717(10) UTERUS/ BRAIN * 100 25.64047 9.36949(17) Data summarized as : Mean Standard Deviation (n) 23.29497 5.19511(11) Statistical Methods: Trend test (Jonckheere-Terpstra). There were no statistically significant differences at p < 0.05. VI-1 100 596.74944 91.10296(9) 0.55308 0.28339(9) 24.21331 6.41813(9) DuPont-5990 Company Sanitized. Does not contain TSCA C8I -416- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 67 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Pi ADULTS SITE/LESION: GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-0 0 20 III-O 25 20 V-0 100 20 SEMINAL VESICLES SMALL ia TESTES SOFT 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 0 0 1 DuPont-5990 VII-0 500 18 0 0 Company Sanitized. Does not contain TSCA CBI -417- o Company Sanitized. Does not contain TSCA CBI ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 68 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Pi ADULTS ) DuPont-5990 SITE/LESION: GROUP DESIGNATION: DOSE (MG/KG): NUMBER IN GROUP: II-0 0 20 IV-0 25 20 LIVER LARGE STOMACH ULCER/EROSION DISCOLORATION 0 i SALIVARY GLANDS DISCOLORATION i URINARY BLADDER CALCULUS 0 KIDNEYS CYST CALCULUS 0 0 PITUITARY GLAND LARGE 0 SKIN STAIN ALOPECIA 0 0 MAMMARY GLANDS MASS 0 a INCIDENCES REFLECT1THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 0 1 0 0 0 0 1 0 0 1 VI-0 100 20 0 1 0 0 1 1 1 2 0 2 0 VIII-0 500 20 2 0 0 0 0 0 0 0 3 4 0 -418- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 69 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi PUPS DuPont-5990 SITE/LESION: DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 VI-0 100 2/1 VIII -0 500 5/5 STOMACH NO MILK SPOT LUNGS NOT EXPANDED WHOLE BODY AUTOLYSIS 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 1 ( 1) 1 ( 1) 0 ( 0) 2 ( 2) 2 ( 2) 2 ( 2) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0014 0014 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -419- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations TABLE 70 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi PUPS ) DuPont-5990 SITE/LESION: DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 2/1 VI-0 100 3/3 VIII -0 500 7/5 STOMACH NO MILK SPOT LUNGS NOT EXPANDED WHOLE BODY CANNIBALIZED AUTOLYSIS 0 ( 0) 0 ( 0) 0 ( 0) 0 { 0) 1 ( 1) 2 ( 1) 0 ( 0) 0 ( 0) 1 ( 1) 1 ( 1) 0 ( 0) 1 ( 1) 4 ( 3) 3 ( 2) 1 ( 1) 1 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0124 022 6 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBI -420- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 71 INCIDENCES OF GROSS OBSERVATIONS IN RATS - F, UNSEXABLE PUPS DuPont-5990 SITE/LESION: DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 VI-0 100 0/0 VIII-0 500 1/1 WHOLE BODY CANNIBALIZED 0 ( 0) 0 ( 0) 0 ( 0) 1 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0001 0001 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 72 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi WEANLINGS DuPont-5990 SITE/LESION: GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 48 III-l 25 34 V-l 100 27 VII-1 500 2 WHOLE BODY SMALL__________________________________________________ 0___________ 0___________ 1____________ 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. Company Sanitized. Does not contain TSCA CBI -422- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 74 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi ADULTS SITE/LESION: GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 17 KIDNEYS DILATATION 0 WHOLE BODY SMALL 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. III-l 25 11 1 0 V-l 100 10 0 0 DuPont-5990 VII-1 500 3 0 1 Company Sanitized. Does not contain TSCA CBI -424- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 75 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi ADULTS DuPont-5990 SITE/LESION: GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-l 0 17 IV-1 25 11 STOMACH DISTENDED WITH GAS 0 SMALL INTESTINE DISTENDED WITH GAS 0 LARGE INTESTINE DISTENDED WITH GAS 0 SKIN STAIN 0 WHOLE BODY SMALL 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 0 0 0 0 VI-1 100 9 0 0 0 0 0 VIII-1 500 3 1 1 1 2 2 Company Sanitized. Does not contain TSCA CBI -425- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 76 INCIDENCESIANNMDALLEESRIOENPRGORDAUDCETSIOOFNMRAICTRSO-SPCiOAPDICULOTBSSERVATIONS DuPont-5990 LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-0 0 20 III-O 25 20 v-o 100 20 VII-0 500 18 + COAGULATING GLANDS + EPIDIDYMIDES OLIGOSPERMIA/GERM CELL DEBRIS, BILATERAL ONE OF A PAIR PRESENT + PROSTATE INFLAMMATION, SUBACUTE/CHRONIC + SEMINAL VESICLES 3 3 1 (1, 3 3 7 7 - 2 (2,-,-,-,-) 7 - 7 7 7 1 (-,-,-,1,-) 2 (2, 7 1 (-,1,-,-,-) 7 1 1 - - 1 - 1 + TESTES3 DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL ONE OF A PAIR PRESENT 3 - 1 (1, 7 - to to 1 1 7 1 (-,-,-,1,-) 2 (2,-,-,-,-) 1 - O THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. O LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. o LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". a One of the pair available for microscopic examination. Sperm parameter evaluation was performed on the second of the pair. Company Sanitized. Does not contain TSCA CBI -426- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 77 INCIDENCESINAFNEDMLAELSEIORNEPGRROADDUECSTOIOFNMRICARTOSS-CPOi PAIDCUOLBTSSERVATIONS DuPont-5990 LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-O 0 20 IV-0 25 20 VI-0 100 20 VIII-0 500 20 + OVARIES 3997 + UTERUS HYPERPLASIA, CYSTIC ENDOMETRIAL INFLAMMATION, SUBACUTE/CHRONIC 3997 - - 1 (-,,1,-,-,-) - - 1 (-,,1, + VAGINA 3997 o THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. O LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". Company Sanitized. Does not contain TSCA CBI -427- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 FIGURES -428Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations FIGURES DuPont-5990 EXPLANATORY NOTES Critical Dates Day 70 LwtThaoeesrxtceiocdrhoaelaypobogdirytatatesatdieofcwrntoiioatmhnnd.tthhpeeomssuta-bmlceahatrniondngifcpeemtoraixoliedcisrtayatrsaendrieemspiaoglrnsta.etdBediondfotyhrewreRepiegrphordtosudccuoticloltenivceetevdaluduatriionngs Day 90 Lonaes-tmdaoyntohfatnesdt3s-umbsotnatnhcreeacdomveirnyisptreartiioodns.for male and female rats designated for Day 91 L91a-sdtadyayexopfobsuodreypweeriigodh.t data collection for male and female rats designated for the Day 94 L91a-sdtadyayexopfotseusrtesupbersitoadn.ce administration for male rats designated for the Day 95 Male rats designated for the 91-day exposure period were sacrificed. Ldaaystedxapyosoufrteesptesruiobds.tance administration for female rats designated for the 91- Day 96 Female rats designated for 91-day exposure period were sacrificed. Day 119 Last day of body weight data collection for rats designated for the one-month recovery period. Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 182 Lmaosnttdharyecoofvneorny-pfaesrtieodd.body weight data collection for rats designated for the 3- Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. -429Company Sanitized. Does not contain TSCA CBI )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations FIGURE 1 MEAN BODY WEIGHTS OF MALE RATS ) DuPont-5990 -- 0 mg/kg/day -B - 25 mg/kg/day -A - 100 mg/kg/day -X - 500 mg/kg/day Company Sanitized. Does not contain TSCA C8I -430- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations FIGURE 2 MEAN BODY WEIGHTS OF FEMALE RATS ) DuPont-5990 -- 0 mg/kg/day -B - 25 mg/kg/day -A - 100 mg/kg/day -X - 500 mg/kg/day Company Sanitized. Does not contain TSCA CBI -431- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 Forelimb Grip Strength (kg) FIGURE 3 MEAN FORELIMB GRIP STRENGTH FOR MALE RATS 2.00 1.80 1.60 1.40 1.20 1.00 0.80 0.60 0.40 0.20 0.00 Baseline Week 13 Assessment Period 0 mg/kg/day B 25 mg/kg/day B 100 mg/kg/day B 500 mg/kg/day * Statistically significant at p < 0.05 Recovery )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations FIGURE 4 MEAN FORELIMB GRIP STRENGTH FOR FEMALE RATS ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI Omg/kg/day 25 mg/kg/day 100 mg/kg/day M 500 mg/kg/day Baseline Week 13 Assessment Period -433- Recovery )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations FIGURE 5 MEAN HINDLIMB GRIP STRENGTH FOR MALE RATS 1.00 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI 0 mg/kg/day H 25 mg/kg/day II 100 mg/kg/day M 500 mg/kg/day * Statistically significant at p < 0.05 0.00 Baseline Week 13 Assessment Period -434- Recovery ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 0.90 0.80 0.70 I 4 0.60 D 0.50 m a 0 e 0.40 3 1 0.30 0.20 0.10 0.00 FIGURE 6 MEAN HINDLIMB GRIP STRENGTH FOR FEMALE RATS Omg/kg/day S 25 mg/kg/day H 100 mg/kg/day M 500 mg/kg/day s*igniSfitcaatinsttiactaplly< 0.05 Baseline Week 13 Assessment Period Recovery Company Sanitized. Does not contain TSCA CBI -435- )) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 FIGURE 7 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL DURATION OF MOVEMENT FOR MALE RATS Company Sanitized. Does not contain TSCA CBI o ow G V e o<0 > o 0 mg/kg/day H 25 mg/kg/day ^ 100 mg/kg/day U 500 mg/kg/day s 3 Q Baseline Week 13 Assessment Period -436- Recovery ) H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 FIGURE 8 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL DURATION OF MOVEMENT FOR FEMALE RATS Company Sanitized. Does not contain TSCA CBI O CD 4C-O G (D 6 o > 0 mg/kg/day H 25 mg/kg/day o 2 ^ 100 mg/kg/day M 500 mg/kg/day 2v 3 Q Baseline Week 13 Assessment Period -437- Recovery )) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations ) DuPont-5990 FIGURE 9 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL NUMBER OF MOVEMENTS FOR MALE RATS Company Sanitized. Does not contain TSCA C8I o <u 00 e oe oo > 0 mg/kg/day B 25 mg/kg/day B 100 mg/kg/day o B 500 mg/kg/day u o 3 Baseline Week 13 Assessment Period -438- Recovery )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 FIGURE 10 MOTOR ACTIVITY ASSESSMENT: MEAN TOTAL NUMBER OF MOVEMENTS FOR FEMALE RATS Company Sanitized. Does not contain TSCA CBI a uC/5 C <D 0 mg/kg/day 6 oi> o S 25 mg/kg/day ^ 100 mg/kg/day B 500 mg/kg/day u XI 6 55 Baseline Week 13 Assessment Period -439- Recovery H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDICES -440- Company Sanitized. Does not contain TSCA C8I H90--2D47a6y8G: aSvuabgcehSrotunidcyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX A ANALYTICAL DATA -441- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Table I. Concentration Verification and Stability of H-24768 in Dosing Solutions Preparation Day __________ mg/mL H-24768__________ Percent Sample Type___________ Nominal_________ Measured_________ Nominal Test Day 0 Concentration Verification(A) Control 0 .0 n d (B) -- 3.33-1 3.33-2 Mean(C); 3.11 2.82 2.97 0.21 C.V. 7% 93.4 84.7 (89.2) 13.33-1 13.33-2() A fe a ( C ); 1121..16 11.90.35 C.V. 3% 9807..80 (89.3) 66.67-1 (D) 66.67-2() Mean(C ); 60.4 55.1 57.8 3.7 C.V. 6% 90.6 82.6 (86.7) 5-Hour RSootambiTliteymperature 5-Hour Room Temperature 5-Hour Room Temperature 3.33(C) 13.33(C) 66.67(C) 2.93 11.6 58.1 88.0 87.0 87.1 4-Day Refrigerated 3.33(C,E) 3.14 94.3 4-Day Refrigerated 13.33(C,E) 12.0 90.0 4-Day Refrigerated 66.67(C,E) 58.9 88.3 (A) ((((EDBC)))) bDDMMDmuoeuieetxnspaantiolunnniotrcgerreabees.stasseonuusloeslluttltatimooidnoeffepntttlesshheaceessmtaepaomdplrel.lirpegalslineenawdvalelyealrasfewetnesateralfrybkoeseeriainstnnhgaoaennlhyddetzuhtlehpdedel.oficoorMairrgti4egeinaisdnanaaalm,ylpSspsr.alerDeemps.fa.rparilagnetedirroeaCnat.enVddaa..lyycSza(etlaecdmsu.tpladlteaesyda3tno9a)lv.yezreifdyausnsitfaobrmiliittyysoafmples -442- Comp'any Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Table I. Concentration Verification and Stability of H-24768 in Dosing Solutions (Continued) Preparation Date mg/mL H-24768 Percent Sample Type Nominal Measured Nominal 7-Mar-2001 Concentration Verification^) Control 0.0 n d C8) -- 5.0-1 5.0-2 Mean: 4.72 4.54 4.630.1 C.V. 3% 94.4 90.8 (92.6) 1100..00--12 Mean: 9.36 8.75 9.050.4 C.V. 5% 9837..56 (90.5) 4400..00--12 Mean: 4308..29 39.60.9 C.V 2% 19070.3.5 (98.9) 70.0-1 70.0-2 Mean: 63.2 61.7 62.41.1 C.V. 2% 90.2 88.1 (89.1) Stability(A) 4-D5aHyoRuerfrRigoeormated Temperature^) 4-D5aHyoRuerfrRigoeormated Temperature(^) 4-D5aHy oRuerfrRigoeormated Temperature(C) 4-D5aHyoRuerfrRigoeormated Temperature(C) 55..00 1100..00 4400..00 7700..00 55..0367 99..7720 4421..13 6894..72 110017..24 97.0 97.2 110035..32 19290.6.3 (A) ((CB)) DcSDaauelmcnpuolpiltlcaeeatssetendhoesttalodmdvefpeotlerreicfs4tyefddruoa.nymisfoWrremfRrii1tgy3e5ora9ft3em,diS,xCtthuer8en4.05 were analyzed. Table included hours at room temperature. for reference. Mean, S.D. and C.V. -443- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 if.Table H Concentration Verification o: -24768 in Dosing Solutions Preparation Day mg/mL H-24768 Percent Sample Type Nominal Measured Nominal Test Day 32 Concentration Verification(A) Control 0 .0 n d CB) -- 3.33-1 3.33-2Mean: 3.05 C3..V30..0781%0.02 91.6 (9922..52) 1133..3333--12Mean: C1.1V11.161...156%0.1 (888767...030) 6666..6677--12Mean: 6C0..6V5419...3701%.9 (998028...565) CToenscteDntaryat4io2n VeriCfiocnattrioonl (A) 0 .0 3.33-1 3.33-2Mean: 1133..3333--12Mean: 6666..6677--12Mean: n d (B) 3.13 C3..V31..2120%0.12 12.5 C12.V1.52..05%0.0 5C8..V55287...1860%.9 -- 94.0 (9933..77) (999333...888) (888778...332) ((AB)) DDeunpolitceastenosatmdeptleecstepde.r level were analyzed. Mean, S.D. and C.V. calculated to verify uniformity ofmixtui -444- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Table Il.(continued) Concentration Verification o f H-24768 in Dosing Solutions Preparation Day mg/mL H-24768 Percent Sample Type N om in al Measured N om in al Test Day 91 Concentration V erification ^ ) Control 0.0 n d (b > -- 3.33-1 3.33-2Mean: 3.17 C3..3V1..1780%0.01 95.2 (9955..52) 13.33-1 13.33-2Mean: 12.4 C12.1V.25..16%0.1 93.0 (9934..58) 66.67-1 6 6 .6 7 - 2Mean: 58.7 5C9..63V0..20%0.9 88.0 (8980..90) ((AB)) DDeunpolitceastenosatmdeptleecstepde.r level were analyzed. Mean, S.D. and C.V. calculated to verify uniformity ofmixture. -445- Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Representative AnFailgyutirceal1Calibration Curve DuPont-5990 Figure la: Calibration curve (R.T. = 7.9 minutes) showing linear fit (line) to replicate peak height measurements (squares) for calibration solutions of H-24768 diluted over a concentration range of 1.0216 to 5.108 mg/mL. Figure lb: Calibration curve (R.T. = 8.2 minutes) showing linear fit (line) to replicate peak height measurements (squares) for calibration solutions of H-24768 diluted over a concentration range of 1.0216 to 5.108 mg/mL. -446- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations RepresentaFtiigvuerAen1a(lcyotinctainl uCeadli)bration Curve DuPont-5990 Concentration, m g/m L Figure lc: Calibration curve (R.T. = 8.5 minutes) showing linear fit (line) to trsooepl5ul.it1ciao0tn8esmpoegfa/Hmk -Lh2e.4i7g6h8t mdielaustuedreomveenrtas c(soqnucaernetsr)atfioorncraalinbgreatoiofn1.0216 Figure Id: Calibration curve (R.T. = 8.9-9.0 minutes) showing linear fit c(lailnibe)ratotiornepsloicluatteiopnesaokfhHei-g2h4t7m68eadsiulurteemdeonvtesr(saqcuoanrceesn) tfroartion range of 1.0216 to 5.108 mg/mL. -447- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Figure 2 Representative Gas Chromatography Chromatoerams DuPont-5990 Figure 2a: Representative GC chromatogram of 0 mg/mL (control) sample. Retention times used for H-24768 are approximately 7.9, 8.2, 8.5, and 9.0 minutes. Figure 2b: Representative GC chromatogram of 66.67 mg/mL H-24768 dosing solution diluted to a nominal concentration of 3.33 mg/mL. The measured concentration of the representative solution is 60.4 mg/mL. Figure 2c: Representative GC chromatogram of 3.315 mg/mL H-24768 analytical reference solution. -448- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX B INDIVIDUAL DOSE VOLUM ES -449- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES EXPLANATORY NOTES Critical Dates Day 70 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Dose volumes administered during the cohabitation and post-mating periods are documented in study records. Day 90 Last day of test substance administration for male and female rats designated for one-month and 3-month recovery periods. Day 94 Last day of test substance administration for male rats designated for the 91-day exposure period. Day 95 Last day of test substance administration for female rats designated for the 91-day exposure period. Day 96 Female rats designated for 91-day exposure period were sacrificed. Footnotes Group I, male rat #646367 was inadvertently not fasted on day 94, prior to bleeding and scheduled sacrifice on day 95. This lack of fasting was discovered on day 95. The rat was dosed on day 95, fasted, then bled for clinical pathology and sacrificed on test day 96. The data for this rat from test day 96 was included with the data for the other rats collected at the time of their sacrifice, on test day 95. The additional day of dosing is not expected to affect results, especially since the rat was a control rat. The extra dosing volume from test day 95 will be reported in the appendix but not included in the table of mean dose volumes, since it was the only male rat dosed on that day. b. On test day 21, Group EH, Rat 646458 was inadvertently dosed twice. c- Animal may not have received total dose. d. Due to error, dose volume was not recorded. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis -450- Company Sanitized. Does not contain TSCA CBI )) ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Day 0 Day 1 Male, I- 0 mg/kg/day 646482 1.5 1.5 646427 1.7 1.7 646360 1.7 1.7 646489 1.8 1.8 646379 1.7 1.7 646485 1.7 1.7 646420 1.6 1.6 646374 1.7 1.7 646367 1.6 1.6 646457 1.7 1.7 646325 1.6 1.6 646396 1.6 1.6 646495 1.4 1.4 646468 1.5 1.5 646490 1.5 1.5 646440 1.6 1.6 646424 1.7 1.7 646402 1.8 1.8 646392 1.7 1.7 646473 1.6 1.6 646395 1.6 1.6 646352 1.5 1.5 646357 1.6 1.6 646409 1.7 1.7 646328 1.6 1.6 646479 1.9 1.9 646470 1.6 1.6 646461 1.6 1.6 646480 1.5 1.5 646383 1.6 1.6 646445 1.5 1.5 646358 1.6 1.6 646425 1.6 1.6 646408 1.7 1.7 646459 1.6 1.6 646460 1.5 1.5 646416 1.6 1.6 646371 1.5 1.5 646411 1.8 1.8 646398 1.5 1.5 646487 1.5 1.5 646446 1.6 1.6 646432 1.7 1.7 646494 1.6 1.6 646492 1.5 1.5 Day 2 1.5 1.7 1.7 1.8 1.7 1.7 1.6 1.7 1.6 1.7 1.6 1.6 1.4 1.5 1.5 1.6 1.7 1.8 1.7 1.6 1.6 1.5 1.6 1.7 1.6 1.9 1.6 1.6 1.5 1.6 1.5 1.6 1.6 1.7 1.6 1.5 1.6 1.5 1.8 1.5 1.5 1.6 1.7 1.6 1.5 INDIVIDUAL DOSE VOLUMES (xnL) Day 3 Day 4 Day 5 Day 6 Day 7 Day 8 1.5 1.5 1.5 1.5 1.9 1.9 1.7 1.7 1.7 1.7 2.1 2.1 1.7 1.7 1.7 1.7 2.2 2.2 1.8 1.8 1.8 1.8 2.3 2.3 1.7 1.7 1.7 1.7 2.1 2.1 1.7 1.7 1.7 1.7 2.1 2.1 1.6 1.6 1.6 1.6 2.1 2.1 1.7 1.7 1.7 1.7 2.2 2.2 1.6 1.6 1.6 1.6 2.0 2.0 1.7 1.7 1.7 1.7 2.1 2.1 1.6 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 1.6 2.0 2.0 1.4 1.4 1.4 1.4 1.7 1.7 1.5 1.5 1.5 1.5 1.9 1.9 1.5 1.5 1.5 1.5 1.9 1.9 1.6 1.6 1.6 1.6 1.9 1.9 1.7 1.7 1.7 1.7 2.1 2.1 1.8 1.8 1.8 1.8 2.3 2.3 1.7 1.7 1.7 1.7 2.1 2.1 1.6 1.6 1.6 1.6 2.1 2.1 1.6 1.6 1.6 1.6 2.0 2.0 1.5 1.5 1.5 1.5 2.0 2.0 1.6 1.6 1.6 1.6 2.0 2.0 1.7 1.7 1.7 1.7 2.2 2.2 1.6 1.6 1.6 1.6 2.1 2.1 1.9 1.9 1.9 1.9 2.5 2.5 1.6 1.6 1.6 1.6 2.0 2.0 1.6 1.6 1.6 1.6 2.1 2.1 1.5 1.5 1.5 1.5 1.9 1.9 1.6 1.6 1.6 1.6 2.1 2.1 1.5 1.5 1.5 1.5 1.9 1.9 1.6 1.6 1.6 1.6 2.0 2.0 1.6 1.6 1.6 1.6 2.0 2.0 1.7 1.7 1.7 1.7 2.1 2.1 1.6 1.6 1.6 1.6 1.9 1.9 1.5 1.5 1.5 1.5 1.9 1.9 1.6 1.6 1.6 1.6 1.9 1.9 1.5 1.5 1.5 1.5 1.8 1.8 1.8 1.8 1.8 1.8 2.4 2.4 1.5 1.5 1.5 1.5 1.9 1.9 1.5 1.5 1.5 1.5 1.9 1.9 1.6 1.6 1.6 1.6 2.1 2.1 1.7 1.7 1.7 1.7 2.2 2.2 1.6 1.6 1.6 1.6 2.0 2.0 1.5 1.5 1.5 1.5 2.0 2.0 Day 9 1.9 2.1 2.2 2.3 2.1 2.1 2.1 2.2 2.0 2.1 2.1 2.0 1.7 1.9 1.9 1.9 2.1 2.3 2.1 2.1 2.0 2.0 2.0 2.2 2.1 2.5 2.0 2.1 1.9 2.1 1.9 2.0 2.0 2.1 1.9 1.9 1.9 1.8 2.4 1.9 1.9 2.1 2.2 2.0 2.0 Day 10 1.9 2.1 2.2 2.3 2.1 2.1 2.1 2.2 2.0 2.1 2.1 2.0 1.7 1.9 1.9 1.9 2.1 2.3 2.1 2.1 2.0 2.0 2.0 2.2 2.1 2.5 2.0 2.1 1.9 2.1 1.9 2.0 2.0 2.1 1.9 1.9 1.9 1.8 2.4 1.9 1.9 2.1 2.2 2.0 2.0 Day 11 1.9 2.1 2.2 2.3 2.1 2.1 2.1 2.2 2.0 2.1 2.1 2.0 1.7 1.9 1.9 1.9 2.1 2.3 2.1 2.1 2.0 2.0 2.0 2.2 2.1 2.5 2.0 2.1 1.9 2.1 1.9 2.0 2.0 2.1 1.9 1.9 1.9 1.8 2.4 1.9 1.9 2.1 2.2 2.0 2.0 Company Sanitized. Does not contain TSCA CBI -451- H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Male, I- 0 mg/kg/day 646482 1.9 1.9 646427 2.1 2.1 646360 2.2 2.2 646489 2.3 2.3 646379 2.1 2.1 646485 2.1 2.1 646420 2.1 2.1 646374 2.2 2.2 646367 2.0 2.0 646457 2.1 2.1 646325 2.1 2.1 646396 2.0 2.0 646495 1.7 1.7 646468 1.9 1.9 646490 1.9 1.9 646440 1.9 1.9 646424 2.1 2.1 646402 2.3 2.3 646392 2.1 2.1 646473 2.1 2.1 646395 2.0 2.0 646352 2.0 2.0 646357 2.0 2.0 646409 2.2 2.2 646328 2.1 2.1 646479 2.5 2.5 646470 2.0 2.0 646461 2.1 2.1 646480 1.9 1.9 646383 2.1 2.1 646445 1.9 1.9 646358 2.0 2.0 646425 2.0 2.0 646408 2.1 2.1 646459 1.9 1.9 646460 1.9 1.9 646416 1.9 1.9 646371 1.8 1.8 646411 2.4 2.4 646398 1.9 1.9 646487 1.9 1.9 646446 2.1 2.1 646432 2.2 2.2 646494 2.0 2.0 646492 2.0 2.0 Day 14 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 15 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 16 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 17 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 18 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 19 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 20 2.3 2.4 2.7 2.8 2.5 2.5 2.5 2.7 2.3 2.6 2.4 2.4 1.9 2.2 2.2 2.3 2.5 2.7 2.6 2.5 2.4 1.5 2.4 2.6 2.5 3.0 2.4 2.4 2.1 2.6 2.2 2.3 2.3 2.4 2.2 2.3 2.3 2.0 3.0 2.3 2.3 2.4 2.6 2.4 2.4 Day 21 2.6 2.7 3.2 3.3 2.8 2.8 3.0 3.1 2.7 3.0 2.8 2.8 2.1 2.5 2.5 2.5 2.8 3.1 3.0 2.9 2.8 2.2 2.8 3.0 2.9 3.5 2.7 2.7 2.4 3.0 2.6 2.7 2.7 2.8 2.4 2.6 2.7 2.3 3.5 2.6 2.7 2.8 3.0 2.8 2.8 Day 22 2.6 2.7 3.2 3.3 2.8 2.8 3.0 3.1 2.7 3.0 2.8 2.8 2.1 2.5 2.5 2.5 2.8 3.1 3.0 2.9 2.8 2.2 2.8 3.0 2.9 3.5 2.7 2.7 2.4 3.0 2.6 2.7 2.7 2.8 2.4 2.6 2.7 2.3 3.5 2.6 2.7 2.8 3.0 2.8 2.8 Day 23 2. 6 2. 7 3. 2 3. 3 2. 8 2. 8 3. 0 3. 1 2. 7 3. 0 2. 8 2. 8 2. 1 2. 5 2. 5 2. 5 2. 8 3. 1 3. 0 2. 9 2. 8 2. 2 2. 8 3. 0 2. 9 3. 5 2. 7 2. 7 2. 4 3. 0 2. 6 2. 7 2. 7 2. 8 2. 4 2. 6 2. 7 2. 3 3. 5 2. 6 2. 7 2. 8 3. 0 2. 8 2. 8 -452- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Male, I- 0 mg/kg/day 646482 2.6 2.6 646427 2.7 2.7 646360 3.2 3.2 646489 3.3 3.3 646379 2.8 2.8 646485 2.8 2.8 646420 3.0 3.0 646374 3.1 3.1 646367 2.7 2.7 646457 3.0 3.0 646325 2.8 2.8 646396 2.8 2.8 646495 2.1 2.1 646468 2.5 2.5 646490 2.5 2.5 646440 2.5 2.5 646424 2.8 2.8 646402 3.1 3.1 646392 3.0 3.0 646473 2.9 2.9 646395 2.8 2.8 646352 2.2 2.2 646357 2.8 2.8 646409 3.0 3.0 646328 2.9 2.9 646479 3.5 3.5 646470 2.7 2.7 646461 2.7 2.7 646480 2.4 2.4 646383 3.0 3.0 646445 2.6 2.6 646358 2.7 2.7 646425 2.7 2.7 646408 2.8 2.8 646459 2.4 2.4 646460 2.6 2.6 646416 2.7 2.7 646371 2.3 2.3 646411 3.5 3.5 646398 2.6 2.6 646487 2.7 2.7 646446 2.8 2.8 646432 3.0 3.0 646494 2.8 2.8 646492 2.8 2.8 Day 26 2.6 2.7 3.2 3.3 2.8 2.8 3.0 3.1 2.7 3.0 2.8 2.8 2.1 2.5 2.5 2.5 2.8 3.1 3.0 2.9 2.8 2.2 2.8 3.0 2.9 3.5 2.7 2.7 2.4 3.0 2.6 2.7 2.7 2.8 2.4 2.6 2.7 2.3 3.5 2.6 2.7 2.8 3.0 2.8 2.8 Day 27 2.6 2.7 3.2 3.3 2.8 2.8 3.0 3.1 2.7 3.0 2.8 2.8 2.1 2.5 2.5 2.5 2.8 3.1 3.0 2.9 2.8 2.2 2.8 3.0 2.9 3.5 2.7 2.7 2.4 3.0 2.6 2.7 2.7 2.8 2.4 2.6 2.7 2.3 3.5 2.6 2.7 2.8 3.0 2.8 2.8 Day 28 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 29 Day 30 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 31 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 32 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 33 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 34 2.9 3.0 3.5 3.6 3.1 3.1 3.4 3.4 3.0 3.3 3.0 3.1 2.3 2.8 2.7 2.7 3.0 3.3 3.3 3.2 3.1 2.6 3.2 3.2 3.2 3.9 3.0 3.0 2.7 3.3 2.8 2.9 2.9 3.0 2.6 2.9 3.0 2.6 3.9 2.9 3.0 3.0 3.3 3.1 3.2 Day 35 3.1 3.2 3.8 4.0 3.3 3.2 3.7 3.7 3.2 3.6 3.2 3.3 2.4 3.0 2.9 2.8 3.3 3.5 3.5 3.5 3.4 2.9 3.4 3.4 3.5 4.2 3.3 3.3 2.9 3.5 3.1 3.1 3.1 3.3 2.8 3.1 3.3 2.7 4.3 3.1 3.1 3.3 3.6 3.3 3.5 -453- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Male, I- 0 mg/kg/day 646482 3.1 3.1 646427 3.2 3.2 646360 3.8 3.8 646489 4.0 4.0 646379 3.3 3.3 646485 3.2 3.2 646420 3.7 3.7 646374 3.7 3.7 646367 3.2 3.2 646457 3.6 3.6 646325 3.2 3.2 646396 3.3 3.3 646495 2.4 2.4 646468 3.0 3.0 646490 2.9 2.9 646440 2.8 2.8 646424 3.3 3.3 646402 3.5 3.5 646392 3.5 3.5 646473 3.5 3.5 646395 3.4 3.4 646352 2.9 2.9 646357 3.4 3.4 646409 3.4 3.4 646328 3.5 3.5 646479 4.2 4.2 646470 3.3 3.3 646461 3.3 3.3 646480 2.9 2.9 646383 3.5 3.5 646445 3.1 3.1 646358 3.1 3.1 646425 3.1 3.1 646408 3.3 3.3 646459 2.8 2.8 646460 3.1 3.1 646416 3.3 3.3 646371 2.7 2.7 646411 4.3 4.3 646398 3.1 3.1 646487 3.1 3.1 646446 3.3 3.3 646432 3.6 3.6 646494 3.3 3.3 646492 3.5 3.5 Day 38 3.1 3.2 3.8 4.0 3.3 3.2 3.7 3.7 3.2 3.6 3.2 3.3 2.4 3.0 2.9 2.8 3.3 3.5 3.5 3.5 3.4 2.9 3.4 3.4 3.5 4.2 3.3 3.3 2.9 3.5 3.1 3.1 3.1 3.3 2.8 3.1 3.3 2.7 4.3 3.1 3.1 3.3 3.6 3.3 3.5 Day 39 3.1 3.2 3.8 4.0 3.3 3.2 3.7 3.7 3.2 3.6 3.2 3.3 2.4 3.0 2.9 2.8 3.3 3.5 3.5 3.5 3.4 2.9 3.4 3.4 3.5 4.2 3.3 3.3 2.9 3.5 3.1 3.1 3.1 3.3 2.8 3.1 3.3 2.7 4.3 3.1 3.1 3.3 3.6 3.3 3.5 Day 40 3.1 3.2 3.8 4.0 3.3 3.2 3.7 3.7 3.2 3.6 3.2 3.3 2.4 3.0 2.9 2.8 3.3 3.5 3.5 3.5 3.4 2.9 3.4 3.4 3.5 4.2 3.3 3.3 2.9 3.5 3.1 3.1 3.1 3.3 2.8 3.1 3.3 2.7 4.3 3.1 3.1 3.3 3.6 3.3 3.5 Day 41 3.1 3.2 3.8 4.0 3.3 3.2 3.7 3.7 3.2 3.6 3.2 3.3 2.4 3.0 2.9 2.8 3.3 3.5 3.5 3.5 3.4 2.9 3.4 3.4 3.5 4.2 3.3 3.3 2.9 3.5 3.1 3.1 3.1 3.3 2.8 3.1 3.3 2.7 4.3 3.1 3.1 3.3 3.6 3.3 3.5 Day 42 3.2 3.3 4.0 4.1 3.4 3.3 3.7 3.9 3.2 3.9 3.4 3.5 2.5 3.2 3.1 3.0 3.4 3.7 3.7 3.7 3.6 3.1 3.6 3.6 3.8 4.5 3.5 3.5 3.1 3.8 3.2 3.3 3.3 3.6 2.9 3.3 3.4 2.8 4.6 3.3 3.4 3.4 3.7 3.6 3.7 Day 43 3.2 3.3 4.0 4.1 3.4 3.3 3.7 3.9 3.2 3.9 3.4 3.5 2.5 3.2 3.1 3.0 3.4 3.7 3.7 3.7 3.6 3.1 3.6 3.6 3.8 4.5 3.5 3.5 3.1 3.8 3.2 3.3 3.3 3.6 2.9 3.3 3.4 2.8 4.6 3.3 3.4 3.4 3.7 3.6 3.7 Day 44 3.2 3.3 4.0 4.1 3.4 3.3 3.7 3.9 3.2 3.9 3.4 3.5 2.5 3.2 3.1 3.0 3.4 3.7 3.7 3.7 3.6 3.1 3.6 3.6 3.8 4.5 3.5 3.5 3.1 3.8 3.2 3.3 3.3 3.6 2.9 3.3 3.4 2.8 4.6 3.3 3.4 3.4 3.7 3.6 3.7 Day 45 3.2 3.3 4.0 4.1 3.4 3.3 3.7 3.9 3.2 3.9 3.4 3.5 2.5 3.2 3.1 3.0 3.4 3.7 3.7 3.7 3.6 3.1 3.6 3.6 3.8 4.5 3.5 3.5 3.1 3.8 3.2 3.3 3.3 3.6 2.9 3.3 3.4 2.8 4.6 3.3 3.4 3.4 3.7 3.6 3.7 Day 46 3.2 3.3 4.0 4.1 3.4 3.3 3.7 3.9 3.2 3.9 3.4 3.5 2.5 3.2 3.1 3.0 3.4 3.7 3.7 3.7 3.6 3.1 3.6 3.6 3.8 4.5 3.5 3.5 3.1 3.8 3.2 3.3 3.3 3.6 2.9 3.3 3.4 2.8 4.6 3.3 3.4 3.4 3.7 3.6 3.7 Day 47 3. 2 3. 3 4. 0 4. 1 3. 4 3. 3 3. 7 3. 9 3. 2 3. 9 3. 4 3. 5 2. 5 3. 2 3. 1 3. 0 3. 4 3. 7 3. 7 3. 7 3. 6 3. 1 3. 6 3. 6 3. 8 4. 5 3. 5 3. 5 3. 1 3. 3. 28 3. 3 3. 3 3. 6 2. 9 3. 3 3. 4 2. 8 4. 6 3. 3 3. 4 3. 4 3. 7 3. 6 3. 7 -454- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Male, I- 0 mg/kg/day 646482 3.2 3.4 646427 3.3 3.5 646360 4.0 4.2 646489 4.1 4.4 646379 3.4 3.6 646485 3.3 3.5 646420 3.7 4.0 646374 3.9 4.2 646367 3.2 3.4 646457 3.9 4.2 646325 3.4 3.5 646396 3.5 3.7 646495 2.5 2.6 646468 3.2 3.4 646490 3.1 3.3 646440 3.0 3.2 646424 3.4 3.6 646402 3.7 3.9 646392 3.7 3.9 646473 3.7 3.9 646395 3.6 3.8 646352 3.1 3.3 646357 3.6 3.8 646409 3.6 3.8 646328 3.8 4.0 646479 4.5 4.7 646470 3.5 3.7 646461 3.5 3.7 646480 3.1 3.2 646383 3.8 3.9 646445 3.2 3.4 646358 3.3 3.5 646425 3.3 3.6 646408 3.6 3.7 646459 2.9 3.1 646460 3.3 3.4 646416 3.4 3.6 646371 2.8 2.9 646411 4.6 4.8 646398 3.3 3.4 646487 3.4 3.5 646446 3.4 3.6 646432 3.7 3.9 646494 3.6 3.7 646492 3.7 3.9 Day 50 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 51 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 52 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 53 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 54 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 55 3.4 3.5 4.2 4.4 3.6 3.5 4.0 4.2 3.4 4.2 3.5 3.7 2.6 3.4 3.3 3.2 3.6 3.9 3.9 3.9 3.8 3.3 3.8 3.8 4.0 4.7 3.7 3.7 3.2 3.9 3.4 3.5 3.6 3.7 3.1 3.4 3.6 2.9 4.8 3.4 3.5 3.6 3.9 3.7 3.9 Day 56 3.5 3.7 4.5 4.6 3.8 3.7 4.2 4.4 3.5 4.2 3.5 3.9 2.6 3.6 3.4 3.4 3.7 4.1 4.1 4.3 4.0 3.4 3.9 3.9 4.2 4.9 3.9 3.8 3.3 4.2 3.4 3.7 3.8 3.9 3.3 3.6 3.8 3.0 5.0 3.6 3.7 3.6 4.1 3.9 4.1 Day 57 3.5 3.7 4.5 4.6 3.8 3.7 4.2 4.4 3.5 4.2 3.5 3.9 2.6 3.6 3.4 3.4 3.7 4.1 4.1 4.3 4.0 3.4 3.9 3.9 4.2 4.9 3.9 3.8 3.3 4.2 3.4 3.7 3.8 3.9 3.3 3.6 3.8 3.0 5.0 3.6 3.7 3.6 4.1 3.9 4.1 Day 58 Day 59 3.5 3.5 3.7 3.7 4.5 4.5 4.6 4.6 3.8 3.8 3.7 3.7 4.2 4.2 4.4 4.4 3.5 3.5 SE TEST DAY 57 3.5 3.5 3.9 3.9 2.6 2.6 3.6 3.6 3.4 3.4 3.4 3.4 3.7 3.7 4.1 4.1 4.1 4.1 4.3 4.3 4.0 4.0 3.4 3.4 3.9 3.9 3.9 3.9 4.2 4.2 4.9 4.9 3.9 3.9 3.8 3.8 3.3 3.3 4.2 4.2 3.4 3.4 3.7 3.7 3.8 3.8 3.9 3.9 3.3 3.3 3.6 3.6 3.8 3.8 3.0 3.0 5.0 5.0 3.6 3.6 3.7 3.7 3.6 3.6 4.1 4.1 3.9 3.9 4.1 4.1 -455- ))) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations_________________________________________________________________ DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Dav 62 Male, I- 0 mg/kg/day 646482 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.7 3.7 646427 3.7 3.7 3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.9 3.9 646360 4.5 4.5 4.5 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.8 4.8 646489 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.7 4.7 646379 3.8 3.8 3.8 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.1 4.1 646485 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.8 3.8 646420 4.2 4.2 4.2 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.5 4.5 646374 4.4 4.4 4.4 4.6 4.6 4.6 4.6 4.6 4.6 4.6 4.7 4.7 646367 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.8 3.8 646457 646325 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 646396 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.9 4.1 4.1 646495 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.7 2.7 646468 3.6 3.6 3.6 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.8 3.8 646490 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.6 646440 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.6 646424 3.7 3.7 3.7 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.9 646402 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.2 4.2 4.2 4.2 646392 4.1 4.1 4.1 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.4 646473 4.3 4.3 4.3 4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.6 646395 4.0 4.0 4.0 4.1 4.1 4.1 4.1 4.1 4.1 4.1 4.3 646352 3.4 3.4 3.4 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.7 646357 3.9 3.9 3.9 4.1 4.1 4.1 4.1 4.1 4.1 4.1 4.2 646409 3.9 3.9 3.9 4.2 4.2 4.2 4.2 4.2 4.2 4.2 4.2 646328 4.2 4.2 4.2 4.4 4.4 4.4 4.4 4.4 4.4 4.4 4.5 646479 4.9 4.9 4.9 5.2 5.2 5.2 5.2 5.2 5.2 5.2 5.3 646470 3.9 3.9 3.9 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.1 646461 3.8 3.8 3.8 3.9 3.9 3.9 3.9 3.9 3.9 3.9 4.0 646480 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.5 646383 4.2 4.2 4.2 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.5 646445 3.4 3.4 3.4 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.7 646358 3.7 3.7 3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.9 646425 3.8 3.8 3.8 3.9 3.9 3.9 3.9 3.9 3.9 3.9 4.0 646408 3.9 3.9 3.9 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.2 646459 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.5 3.5 646460 3.6 3.6 3.6 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.8 3.8 646416 3.8 3.8 3.8 3.9 3.9 3.9 3.9 3.9 3.9 3.9 4.0 4.0 646371 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.1 3.1 646411 5.0 5.0 5.0 5.2 5.2 5.2 5.2 5.2 5.2 5.2 5.2 5.2 646398 3.6 3.6 3.6 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.9 3.9 646487 3.7 3.7 3.7 3.9 3.9 3.9 3.9 3.9 3.9 3.9 4.0 4.0 646446 3.6 3.6 3.6 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.9 3.9 646432 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.2 4.2 4.2 4.2 4.2 646494 3.9 3.9 3.9 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.1 4.1 646492 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.2 4.2 4.2 4.4 4.4 -456- Company Sanitized. Does not contain TSCA C8I H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Male, I- 0 mg/kg/day 646482 3.7 3.7 646427 3.9 3.9 646360 4.8 4.8 646489 4.7 4.7 646379 4.1 4.1 646485 3.8 3.8 646420 4.5 4.5 646374 4.7 4.7 646367 3.8 3.8 646457 646325 3.6 3.6 646396 4.1 4.1 646495 2.7 2.7 646468 3.8 3.8 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 3.5 3.5 646460 3.8 3.8 646416 4.0 4.0 646371 3.1 3.1 646411 5.2 5.2 646398 3.9 3.9 646487 4.0 4.0 646446 3.9 3.9 646432 4.2 4.2 646494 4.1 4.1 646492 4.4 4.4 Day 74 3.7 3.9 4.8 4.7 4.1 3.8 4.5 4.7 3.8 3.6 4.1 2.7 3.8 3.5 3.8 4.0 3.1 5.2 3.9 4.0 3.9 4.2 4.1 4.4 Day 75 3.7 3.9 4.8 4.7 4.1 3.8 4.5 4.7 3.8 3.6 4.1 2.7 3.8 3.5 3.8 4.0 3.1 5.2 3.9 4.0 3.9 4.2 4.1 4.4 Day 76 3.7 3.9 4.8 4.7 4.1 3.8 4.5 4.7 3.8 3.6 4.1 2.7 3.8 3.5 3.8 4.0 3.1 5.2 3.9 4.0 3.9 4.2 4.1 4.4 Day 77 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 78 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 79 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 80 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 81 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 82 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 Day 83 3.8 4.0 4.9 4.8 4.3 4.0 4.6 4.8 3.9 3.7 4.2 2.7 3.9 3.6 3.8 4.0 3.2 5.4 3.8 4.1 4.0 4.3 4.2 4.5 -457- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) } DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Male, I- 0 mg/kg/day 646482 3.9 3.9 646427 4.1 4.1 646360 5.0 5.0 646489 4.8 4.8 646379 4.4 4.4 646485 4.1 4.1 646420 4.7 4.7 646374 5.0 5.0 646367 4.0 4.0 646457 646325 3.8 3.8 646396 4.3 4.3 646495 2.7 2.7 646468 4.0 4.0 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 3.7 3.7 646460 3.9 3.9 646416 4.1 4.1 646371 3.3 3.3 646411 5.5 5.5 646398 3.9 3.9 646487 4.1 4.1 646446 4.1 4.1 646432 4.4 4.4 646494 4.3 4.3 646492 4.7 4.7 Day 86 3.9 4.1 5.0 4.8 4.4 4.1 4.7 5.0 4.0 3.8 4.3 2.7 4.0 3.7 3.9 4.1 3.3 5.5 3.9 4.1 4.1 4.4 4.3 4.7 Day 87 3.9 4.1 5.0 4.8 4.4 4.1 4.7 5.0 4.0 3.8 4.3 2.7 4.0 3.7 3.9 4.1 3.3 5.5 3.9 4.1 4.1 4.4 4.3 4.7 Day 88 3.9 4.1 5.0 4.8 4.4 4.1 4.7 5.0 4.0 3.8 4.3 2.7 4.0 3.7 3.9 4.1 3.3 5.5 3.9 4.1 4.1 4.4 4.3 4.7 Day 89 Day 90 3.9 4.1 5.0 4.8 4.4 4.1 4.7 5.0 4.0 3.8 ' 4.3 2.7 4.0 3.9 4.1 5.0 4.8 4.4 4.1 4.7 5.0 4.0 3.8 4.3 2.7 4.0 3.7 3.7 3.9 3.9 4.1 4.1 3.3 3.3 5.5 5.5 3.9 3.9 4.1 4.1 4.1 4.1 4.4 4.4 4.3 4.3 4.7 4.7 Day 91 4.0 4.1 5.1 4.9 4.5 4.2 4.7 5.1 4.1 Day 92 4.0 4.1 5.1 4.9 4.5 4.2 4.7 5.1 4.1 Day 93 4.0 4.1 5.1 4.9 4.5 4.2 4.7 5.1 4.1 Day 94 4.0 4.1 5.1 4.9 4.5 4.2 4.7 5.1 4.1 Day 95 4.1 a -458- )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Male, III - 25 mg/kg/day 646454 1.5 1.5 646399 1.7 1.7 646370 1.8 1.8 646443 1.7 1.7 646423 1.7 1.7 646421 1.7 1.7 646471 1.8 1.8 646426 1.6 1.6 646414 1.6 1.6 646458 1.7 1.7 646368 1.7 1.7 646438 1.6 1.6 646436 1.6 1.6 646449 1.5 1.5 646453 1.5 1.5 646378 1.5 1.5 646483 1.7 1.7 646363 1.8 1.8 646334 1.8 1.8 646493 1.7 1.7 646404 1.7 1.7 646415 1.5 1.5 646410 1.6 1.6 646340 1.5 1.5 646354 1.5 1.5 646467 1.7 1.7 646381 1.6 1.6 646342 1.7 1.7 646450 1.6 1.6 646326 1.6 1.6 646377 1.6 1.6 646478 1.8 1.8 646350 1.6 1.6 646333 1.5 1.5 646486 1.5 1.5 Day 2 1.5 1.7 1.8 1.7 1.7 1.7 1.8 1.6 1.6 1.7 1.7 1.6 1.6 1.5 1.5 1.5 1.7 1.8 1.8 1.7 1.7 1.5 1.6 1.5 1.5 1.7 1.6 1.7 1.6 1.6 1.6 1.8 1.6 1.5 1.5 Day 3 1.5 1.7 1.8 1.7 1.7 1.7 1.8 1.6 1.6 1.7 1.7 1.6 1.6 1.5 1.5 1.5 1.7 1.8 1.8 1.7 1.7 1.5 1.6 1.5 1.5 1.7 1.6 1.7 1.6 1.6 1.6 1.8 1.6 1.5 1.5 Day 4 1.5 1.7 1.8 1.7 1.7 1.7 1.8 1.6 1.6 1.7 1.7 1.6 1.6 1.5 1.5 1.5 1.7 1.8 1.8 1.7 1.7 1.5 1.6 1.5 1.5 1.7 1.6 1.7 1.6 1.6 1.6 1.8 1.6 1.5 1.5 Day 5 1.5 1.7 1.8 1.7 1.7 1.7 1.8 1.6 1.6 1.7 1.7 1.6 1.6 1.5 1.5 1.5 1.7 1.8 1.8 1.7 1.7 1.5 1.6 1.5 1.5 1.7 1.6 1.7 1.6 1.6 1.6 1.8 1.6 1.5 1.5 Day 6 1.5 1.7 1.8 1.7 1.7 1.7 1.8 1.6 1.6 1.7 1.7 1.6 1.6 1.5 1.5 1.5 1.7 1.8 1.8 1.7 1.7 1.5 1.6 1.5 1.5 1.7 1.6 1.7 1.6 1.6 1.6 1.8 1.6 1.5 1.5 Day 7 1.9 2.2 2.2 2.1 2.1 2.1 2.3 2.0 2.0 2.1 2.2 1.9 2.0 1.8 1.7 1.9 2.1 2.2 2.3 2.2 2.1 1.9 2.0 1.9 1.9 2.1 2.0 2.1 2.0 2.1 2.1 2.3 2.0 1.9 1.8 Day 8 1.9 2.2 2.2 2.1 2.1 2.1 2.3 2.0 2.0 2.1 2.2 1.9 2.0 1.8 1.7 1.9 2.1 2.2 2.3 2.2 2.1 1.9 2.0 1.9 1.9 2.1 2.0 2.1 2.0 2.1 2.1 2.3 2.0 1.9 1.8 Day 9 1.9 2.2 2.2 2.1 2.1 2.1 2.3 2.0 2.0 2.1 2.2 1.9 2.0 1.8 1.7 1.9 2.1 2.2 2.3 2.2 2.1 1.9 2.0 1.9 1.9 2.1 2.0 2.1 2.0 2.1 2.1 2.3 2.0 1.9 1.8 Day 10 1.9 2.2 2.2 2.1 2.1 2.1 2.3 2.0 2.0 2.1 2.2 1.9 2.0 1.8 1.7 1.9 2.1 2.2 2.3 2.2 2.1 1.9 2.0 1.9 1.9 2.1 2.0 2.1 2.0 2.1 2.1 2.3 2.0 1.9 1.8 Day 11 1.9 2.2 2.2 2.1 2.1 2.1 2.3 2.0 2.0 2.1 2.2 1.9 2.0 1.8 1.7 1.9 2.1 2.2 2.3 2.2 2.1 1.9 2.0 1.9 1.9 2.1 2.0 2.1 2.0 2.1 2.1 2.3 2.0 1.9 1.8 Company Sanitized. Does not contain TSCA CBI -459- H90-2-D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Male, III - 25 mg/kg/day 646454 1.9 1.9 646399 2.2 2.2 646370 2.2 2.2 646443 2.1 2.1 646423 2.1 2.1 646421 2.1 2.1 646471 2.3 2.3 646426 2.0 2.0 646414 2.0 2.0 646458 2.1 2.1 646368 2.2 2.2 646438 1.9 1.9 646436 2.0 2.0 646449 1.8 1.8 646453 1.7 1.7 646378 1.9 1.9 646483 2.1 2.1 646363 2.2 2.2 646334 2.3 2.3 646493 2.2 2.2 646404 2.1 2.1 646415 1.9 1.9 646410 2.0 2.0 646340 1.9 1.9 646354 1.9 1.9 646467 2.1 2.1 646381 2.0 2.0 646342 2.1 2.1 646450 2.0 2.0 646326 2.1 2.1 646377 2.1 2.1 646478 2.3 2.3 646350 2.0 2.0 646333 1.9 1.9 646486 1.8 1.8 Day 14 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 15 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 16 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 17 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 18 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 19 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 20 2.3 2.7 2.6 2.5 2.5 2.4 2.9 2.4 2.5 2.6 2.5 2.3 2.4 2.1 2.0 2.3 2.6 2.6 2.6 2.7 2.5 2.3 2.5 2.2 2.3 2.6 2.4 2.5 2.4 2.4 2.5 2.8 2.4 2.3 2.1 Day 21 Day 22 2.6 3.2 2.9 2.9 2.9 2.9 3.3 2.7 2.9 5.7 b 2.9 2.7 2.8 2.5 2.3 2.7 3.0 2.9 2.8 3.0 2.9 2.6 2.9 2.5 2.7 3.0 2.8 2.9 2.8 2.8 2.9 3.3 2.8 2.7 2.3 2.6 3.2 2.9 2.9 2.9 2.9 3.3 2.7 2.9 3.0 2.9 2.7 2.8 2.5 2.3 2.7 3.0 2.9 2.8 3.0 2.9 2.6 2.9 2.5 2.7 3.0 2.8 2.9 2.8 2.8 2.9 3.3 2.8 2.7 2.3 Day 23 2. 6 3. 2 2. 9 2. 9 2. 9 2. 9 3. 3 2..7 2. 9 3. 0 2. 9 2. 7 2. 8 2. 5 2. 3 2. 7 3. 0 2. 9 2. 8 3. 0 2. 9 2. 6 2. 9 2. 5 2. 7 3. 0 2. 8 2. 9 2. 8 2. 8 2. 9 3. 3 2. 8 2. 7 2. 3 Company Sanitized. Does not contain TSCA o CD )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations_________________________________________________________________ DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Male, III - 25 mg/kg/day 646454 2.6 2.6 646399 3.2 3.2 646370 2.9 2.9 646443 2.9 2.9 646423 2.9 2.9 646421 2.9 2.9 646471 3.3 3.3 646426 2.7 2.7 646414 2.9 2.9 646458 3.0 3.0 646368 2.9 2.9 646438 2.7 2.7 646436 2.8 2.8 646449 2.5 2.5 646453 2.3 2.3 646378 2.7 2.7 646483 3.0 3.0 646363 2.9 2.9 646334 2.8 2.8 646493 3.0 3.0 646404 2.9 2.9 646415 2.6 2.6 646410 2.9 2.9 646340 2.5 2.5 646354 2.7 2.7 646467 3.0 3.0 646381 2.8 2.8 646342 2.9 2.9 646450 2.8 2.8 646326 2.8 2.8 646377 2.9 2.9 646478 3.3 3.3 646350 2.8 2.8 646333 2.7 2.7 646486 2.3 2.3 Day 26 Day 27 2.6 3.2 2.9 2.9 2.9 2.9 3.3 2.7 2.9 3.0 2.9 2.7 2.8 c 2.5 2.3 2.7 3.0 2.9 2.8 3.0 2.9 2.6 2.9 2.5 2.7 3.0 2.8 2.9 2.8 2.8 2.9 3.3 2.8 2.7 2.3 2.6 3.2 2.9 2.9 2.9 2.9 3.3 2.7 2.9 3.0 2.9 2.7 2.8 2.5 2.3 2.7 3.0 2.9 2.8 3.0 2.9 2.6 2.9 2.5 2.7 3.0 2.8 2.9 2.8 2.8 2.9 3.3 2.8 2.7 2.3 Day 28 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 29 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 30 3-0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3-1 3.1 3.2 3.7 3.0 3.0 2.5 Day 31 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 32 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 33 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 34 3.0 3.6 3.2 3.3 3.2 3.1 3.8 2.9 3.3 3.3 3.1 3.0 3.2 2.9 2.6 3.0 3.3 3.2 3.1 3.4 3.2 3.0 3.2 2.7 3.0 3.4 3.1 3.4 3.1 3.1 3.2 3.7 3.0 3.0 2.5 Day 35 3.2 3.9 3.3 3.5 3.4 3.3 4.1 3.1 3.6 3.5 3.3 3.2 3.4 3.2 2.7 3.1 3.6 3.4 3.3 3.7 3.4 3.3 3.4 3.0 3.3 3.7 3.3 3.6 3.3 3.3 3.5 4.2 3.3 3.2 2.6 Company Sanitized. Does not contain TSCA CBI -461- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Male, i n - 25 mg/kg/day 646454 3.2 3.2 646399 3.9 3.9 646370 3.3 3.3 646443 3.5 3.5 646423 3.4 3.4 646421 3.3 3.3 646471 4.1 4.1 646426 3.1 3.1 646414 3.6 3.6 646458 3.5 3.5 646368 3.3 3.3 646438 3.2 3.2 646436 3.4 3.4 646449 3.2 3.2 646453 2.7 2.7 646378 3.1 3.1 646483 3.6 3.6 646363 3.4 3.4 646334 3.3 3.3 646493 3.7 3.7 646404 3.4 3.4 646415 3.3 3.3 646410 3.4 3.4 646340 3.0 3.0 646354 3.3 3.3 646467 3.7 3.7 646381 3.3 3.3 646342 3.6 3.6 646450 3.3 3.3 646326 3.3 3.3 646377 3.5 3.5 646478 4.2 4.2 646350 3.3 3.3 646333 3.2 3.2 646486 2.6 2.6 Day 38 3.2 3.9 3.3 3.5 3.4 3.3 4.1 3.1 3.6 3.5 3.3 3.2 3.4 3.2 2.7 3.1 3.6 3.4 3.3 3.7 3.4 3.3 3.4 3.0 3.3 3.7 3.3 3.6 3.3 3.3 3.5 4.2 3.3 3.2 2.6 Day 39 3.2 3.9 3.3 3.5 3.4 3.3 4.1 3.1 3.6 3.5 3.3 3.2 3.4 3.2 2.7 3.1 3.6 3.4 3.3 3.7 3.4 3.3 3.4 3.0 3.3 3.7 3.3 3.6 3.3 3.3 3.5 4.2 3.3 3.2 2.6 Day 40 3.2 3.9 3.3 3.5 3.4 3.3 4.1 3.1 3.6 3.5 3.3 3.2 3.4 3.2 2.7 3.1 3.6 3.4 3.3 3.7 3.4 3.3 3.4 3.0 3.3 3.7 3.3 3.6 3.3 3.3 3.5 4.2 3.3 3.2 2.6 Day 41 3.2 3.9 3.3 3.5 3.4 3.3 4.1 3.1 3.6 3.5 3.3 3.2 3.4 3.2 2.7 3.1 3.6 3.4 3.3 3.7 3.4 3.3 3.4 3.0 3.3 3.7 3.3 3.6 3.3 3.3 3.5 4.2 3.3 3.2 2.6 Day 42 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Day 43 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Day 44 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Day 45 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Day 46 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Day 47 3.4 4.1 3.3 3.6 3.6 3.5 4.2 3.2 3.7 3.7 3.5 3.4 3.6 3.4 2.9 3.3 3.8 3.6 3.6 3.9 3.8 3.5 3.7 3.1 3.5 3.9 3.6 3.9 3.6 3.6 3.7 4.5 3.5 3.4 2.8 Company Sanitized. Does not contain TSCA CBI -462- )) ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Male, III - 25 mg/kg/day 646454 3.4 3.6 646399 4.1 4.4 646370 3.3 3.5 646443 3.6 3.8 646423 3.6 3.8 646421 3.5 3.7 646471 4.2 4.5 646426 3.2 3.5 646414 3.7 3.8 646458 3.7 3.9 646368 3.5 3.6 646438 3.4 3.5 646436 3.6 3.8 646449 3.4 3.6 646453 2.9 3.0 646378 3.3 3.5 646483 3.8 3.9 646363 3.6 3.8 646334 3.6 3.7 646493 3.9 4.1 646404 3.8 4.0 646415 3.5 3.6 646410 3.7 3.8 646340 3.1 3.3 646354 3.5 3.6 646467 3.9 4.1 646381 3.6 3.8 646342 3.9 4.0 646450 3.6 3.7 646326 3.6 3.8 646377 3.7 3.9 646478 4.5 4.7 646350 3.5 3.8 646333 3.4 3.6 646486 2.8 2.9 Day 50 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 51 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 52 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 53 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 54 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 55 3.6 4.4 3.5 3.8 3.8 3.7 4.5 3.5 3.8 3.9 3.6 3.5 3.8 3.6 3.0 3.5 3.9 3.8 3.7 4.1 4.0 3.6 3.8 3.3 3.6 4.1 3.8 4.0 3.7 3.8 3.9 4.7 3.8 3.6 2.9 Day 56 3.8 4.7 3.7 4.0 4.0 3.9 4.7 3.7 4.0 4.1 3.8 3.7 4.0 3.8 3.1 3.6 4.1 3.9 3.9 4.2 4.1 3.8 3.8 3.4 3.8 4.3 4.0 4.2 3.9 3.9 4.1 4.9 3.9 3.7 3.0 Day 57 3.8 4.7 3.7 4.0 4.0 3.9 4.7 3.7 4.0 4.1 3.8 3.7 4.0 3.8 3.1 3.6 4.1 3.9 3.9 4.2 4.1 3.8 3.8 3.4 3.8 4.3 4.0 4.2 3.9 3.9 4.1 4.9 3.9 3.7 3.0 Day 58 3.8 4.7 3.7 4.0 4.0 3.9 4.7 3.7 4.0 4.1 3.8 3.7 4.0 3.8 3.1 3.6 4.1 3.9 3.9 4.2 4.1 3.8 3.8 3.4 3.8 4.3 4.0 4.2 3.9 3.9 4.1 4.9 3.9 3.7 3.0 Day 59 3.8 4.7 3.7 4.0 4.0 3.9 4.7 3.7 4.0 4.1 3.8 3.7 4.0 3.8 3.1 3.6 4.1 3.9 3.9 4.2 4.1 3.8 3.8 3.4 3.8 4.3 4.0 4.2 3.9 3.9 4.1 4.9 3.9 3.7 3.0 Company Sanitized. Does not contain TSCA C8I -463- H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Male, III - 25 mg/kg/day 646454 3.8 3.8 646399 4.7 4.7 646370 3.7 3.7 646443 4.0 4.0 646423 4.0 4.0 646421 3.9 3.9 646471 4.7 4.7 646426 3.7 3.7 646414 4.0 4.0 646458 4.1 4.1 646368 3.8 3.8 646438 3.7 3.7 646436 4.0 4.0 646449 3.8 3.8 646453 3.1 3.1 646378 3.6 3.6 646483 4.1 4.1 646363 3.9 3.9 646334 3.9 3.9 646493 4.2 4.2 646404 4.1 4.1 646415 3.8 3.8 646410 3.8 3.8 646340 3.4 3.4 646354 3.8 3.8 646467 4.3 4.3 646381 4.0 4.0 646342 4.2 4.2 646450 3.9 3.9 646326 3.9 3.9 646377 4.1 4.1 646478 4.9 4.9 646350 3.9 3.9 646333 3.7 3.7 646486 3.0 3.0 Day 62 3.8 4.7 3.7 4.0 4.0 3.9 4.7 3.7 4.0 4.1 3.8 3.7 4.0 3.8 3.1 3.6 4.1 3.9 3.9 4.2 4.1 3.8 3.8 3.4 3.8 4.3 4.0 4.2 3.9 3.9 4.1 4.9 3.9 3.7 3.0 Day 63 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 64 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 65 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 66 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 67 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 68 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 69 3.8 4.9 3.8 4.1 4.1 4.0 4.9 3.9 4.1 4.2 3.9 3.8 4.1 3.9 3.2 3.7 4.2 4.0 4.1 4.5 4.2 4.0 4.0 3.5 3.9 4.4 4.2 4.3 4.0 4.1 3.9 5.1 4.0 3.8 3.2 Day 70 4.0 5.0 3.9 4.3 4.3 4.1 5.0 4.0 4.3 4.3 4.1 4.0 4.2 4.0 3.4 3.8 4.4 4.1 4.2 4.6 4.4 4.2 4.1 3.7 4.1 4.6 4.3 4.5 4.1 4.2 4.1 5.3 4.1 4.0 3.3 Day 71 oo4. 5. 3. 9 4. 3 4. 3 4. 1 5. 0 4. 0 4. 3 4. 3 4. 1 4. 0 4. 2 4. 0 3. 4 Company Sanitized. Does not contain TSCA CBi -464- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Male, III - 25 mg/kg/day 646454 4.0 4.0 646399 5.0 5.0 646370 3.9 3.9 646443 4.3 4.3 646423 4.3 4.3 646421 4.1 4.1 646471 5.0 5.0 646426 4.0 4.0 646414 4.3 4.3 646458 4.3 4.3 646368 4.1 4.1 646438 4.0 4.0 646436 4.2 4.2 646449 4.0 4.0 646453 3.4 3.4 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 Day 74 4.0 5.0 3.9 4.3 4.3 4.1 5.0 4.0 4.3 4.3 4.1 4.0 4.2 4.0 3.4 Day 75 4.0 5.0 3.9 4.3 4.3 4.1 5.0 4.0 4.3 4.3 4.1 4.0 4.2 4.0 3.4 Day 76 4.0 5.0 3.9 4.3 4.3 4.1 5.0 4.0 4.3 4.3 4.1 4.0 4.2 4.0 3.4 Day 77 4.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 78 4.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 79 5.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 80 4.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 81 4.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 82 4.0 5.1 4.0 4.5 4.4 4.2 5.1 4.2 4.4 4.5 4.2 4.0 4.3 4.1 3.4 Day 83 4. 0 5. 1 4. 0 4. 5 4. 4 4. 2 5. 1 4. 2 4. 4 4. 5 4. 2 4. 0 4. 3 4. 1 3. 4 Company Sanitized. Does not contain TSCA CBI -465- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Male, III - 25 mg/kg/day 646454 4.1 4.1 646399 5.3 5.3 646370 4.1 4.1 646443 4.6 4.6 646423 4.4 4.4 646421 4.3 4.3 646471 5.2 5.2 646426 4.3 4.3 646414 4.4 4.4 646458 4.6 4.6 646368 4.2 4.2 646438 3.9 3.9 646436 4.4 4.4 646449 4.3 4.3 646453 3.5 3.5 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 Day 86 4.1 5.3 4.1 4.6 4.4 4.3 5.2 4.3 4.4 4.6 4.2 3.9 4.4 4.3 3.5 Day 87 4.1 5.3 4.1 4.6 4.4 4.3 5.2 4.3 4.4 4.6 4.2 3.9 4.4 4.3 3.5 Day 88 4.1 5.3 4.1 4.6 4.4 4.3 5.2 4.3 4.4 4.6 4.2 3.9 4.4 4.3 3.5 Day 89 4.1 5.3 4.1 4.6 4.4 4.3 5.2 4.3 4.4 4.6 4.2 3.9 4.4 4.3 3.5 Day 90 4.1 5.3 4.1 4.6 4.4 4.3 5.2 4.3 4.4 4.6 4.2 3.9 4.4 4.3 3.5 Day 91 4.1 5.4 4.2 4.6 4.5 4.3 5.4 4.5 4.6 4.6 Day 92 4.1 5.4 4.2 4.6 4.5 4.3 5.4 4.5 4.6 4.6 Day 93 4.1 5.4 4.2 4.6 4.5 4.3 5.4 4.5 4.6 4.6 Day 94 4.1 5.4 4.2 4.6 4.5 4.3 5.4 4.5 4.6 4.6 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -466- ) )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Male, V - 100 mg/kg/day 646349 1.5 1.5 646463 1.6 1.6 646456 1.8 1.8 646469 1.7 1.7 646472 1.7 1.7 646385 1.7 1.7 646373 1.7 1.7 646435 1.6 1.6 646488 1.8 1.8 646455 1.6 1.6 646335 1.8 1.8 646477 1.6 1.6 646327 1.6 1.6 646403 1.5 1.5 646353 1.5 1.5 646341 1.7 1.7 646356 1.8 1.8 646330 1.9 1.9 646499 1.7 1.7 646400 1.6 1.6 646417 1.5 1.5 646338 1.6 1.6 646394 1.7 1.7 646387 1.6 1.6 646447 1.7 1.7 646336 1.5 1.5 646366 1.7 1.7 646496 1.6 1.6 646375 1.6 1.6 646465 1.6 1.6 646390 1.5 1.5 646429 1.6 1.6 646476 1.6 1.6 646348 1.6 1.6 646376 1.5 1.5 Day 2 1.5 1.6 1.8 1.7 1.7 1.7 1.7 1.6 1.8 1.6 1.8 1.6 1.6 1.5 1.5 1.7 1.8 1.9 1.7 1.6 1.5 1.6 1.7 1.6 1.7 1.5 1.7 1.6 1.6 1.6 1.5 1.6 1.6 1.6 1.5 Day 3 1.5 1.6 1.8 1.7 1.7 1.7 1.7 1.6 1.8 1.6 1.8 1.6 1.6 1.5 1.5 1.7 1.8 1.9 1.7 1.6 1.5 1.6 1.7 1.6 1.7 1.5 1.7 1.6 1.6 1.6 1.5 1.6 1.6 1.6 1.5 Day 4 1.5 1.6 1.8 1.7 1.7 1.7 1.7 1.6 1.8 1.6 1.8 1.6 1.6 1.5 1.5 1.7 1.8 1.9 1.7 1.6 1.5 1.6 1.7 1.6 1.7 1.5 1.7 1.6 1.6 1.6 1.5 1.6 1.6 1.6 1.5 Day 5 Day 6 Day 7 1.5 1.6 1.8 1.7 1.7 1.7 1.7 1.6 1.8 1.6 1.8' 1.6 1.6 1.5 1.5 1.7 1.8 1.9 1.7 1.6 1.5 1.6 1.7 1.6 1.7 1.5 1.7 1.6 1.6 1.6 1.5 1.6 1.6 1.6 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.7 1.6 1.8 1.6 1.8 1.6 1.6 1.5 1.5 1.7 1.8 1.9 1.7 1.6 1.5 1.6 1.7 1.6 1.7 1.5 1.7 1.6 1.6 1.6 1.5 1.6 1.6 1.6 1.5 1.9 2.0 2.2 2.0 1.9 2.0 2.2 2.0 2.2 2.1 2.1 2.0 2.0 1.8 1.8 2.0 2.1 2.2 2.2 2.0 1.9 2.0 2.1 2.0 2.1 1.9 2.1 2.0 2.0 2.0 1.7 2.0 1.7 2.0 1.9 Day 8 1.9 2.0 2.2 2.0 1.9 2.0 2.2 2.0 2.2 2.1 2.1 2.0 2.0 1.8 1.8 2.0 2.1 2.2 2.2 2.0 1.9 2.0 2.1 2.0 2.1 1.9 2.1 2.0 2.0 2.0 1.7 2.0 1.7 2.0 1.9 Day 9 1.9 2.0 2.2 2.0 1.9 2.0 2.2 2.0 2.2 2.1 2.1 2.0 2.0 1.8 1.8 2.0 2.1 2.2 2.2 2.0 1.9 2.0 2.1 2.0 2.1 1.9 2.1 2.0 2.0 2.0 1.7 2.0 1.7 2.0 1.9 Day 10 1.9 2.0 2.2 2.0 1.9 2.0 2.2 2.0 2.2 2.1 2.1 2.0 2.0 1.8 1.8 2.0 2.1 2.2 2.2 2.0 1.9 2.0 2.1 2.0 2.1 1.9 2.1 2.0 2.0 2.0 1.7 2.0 1.7 2.0 1.9 Day 11 1.9 2.0 2.2 2.0 1.9 2.0 2.2 2.0 2.2 2.1 2.1 2.0 2.0 1.8 1.8 2.0 2.1 2.2 2.2 2.0 1.9 2.0 2.1 2.0 2.1 1.9 2.1 2.0 2.0 2.0 1.7 2.0 1.7 2.0 1.9 Company Sanitized. Does not contain TSCA CBI -467- H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Male, V - 100 mg/kg/day 646349 1.9 1.9 646463 2.0 2.0 646456 2.2 2.2 646469 2.0 2.0 646472 1.9 1.9 646385 2.0 2.0 646373 2.2 2.2 646435 2.0 2.0 646488 2.2 2.2 646455 2.1 2.1 646335 2.1 2.1 646477 2.0 2.0 646327 2.0 2.0 646403 1.8 1.8 646353 1.8 1.8 646341 2.0 2.0 646356 2.1 2.1 646330 2.2 2.2 646499 2.2 2.2 646400 2.0 2.0 646417 1.9 1.9 646338 2.0 2.0 646394 2.1 2.1 646387 2.0 2.0 646447 2.1 2.1 646336 1.9 1.9 646366 2.1 2.1 646496 2.0 2.0 646375 2.0 2.0 646465 2.0 2.0 646390 1.7 1.7 646429 2.0 2.0 646476 1.7 1.7 646348 2.0 2.0 646376 1.9 1.9 Day 14 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 15 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 16 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 17 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 18 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 19 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 20 2.3 2.4 2.6 2.4 2.2 2.4 2.7 2.3 2.3 2.4 2.5 2.2 2.3 2.2 2.2 2.4 2.5 2.6 2.6 2.4 2.3 2.3 2.5 2.4 2.4 2.2 2.4 2.4 2.5 2.4 2.0 2.4 2.1 2.3 2.1 Day 21 2.6 2.7 3.0 2.8 2.4 2.8 3.1 2.7 2.7 2.8 2.8 2.5 2.6 2.5 2.5 2.8 2.9 2.8 2.9 2.8 2.6 2.6 3.0 2.7 2.6 2.5 2.6 2.7 2.8 2.7 2.2 2.8 2.4 2.7 2.4 Day 22 2.6 2.7 3.0 2.8 2.4 2.8 3.1 2.7 2.7 2.8 2.8 2.5 2.6 2.5 2.5 2.8 2.9 2.8 2.9 2.8 2.6 2.6 3.0 2.7 2.6 2.5 2.6 2.7 2.8 2.7 2.2 2.8 2.4 2.7 2.4 Day 23 2. 6 2. 7 3. 0 2. 8 2. 4 2. 8 3. 1 2. 7 2. 7 2. 8 2. 8 2. 5 2. 6 2. 5 2. 5 2. 8 2. 9 2. 8 2. 9 2. 8 2 .6 2. 6 3. 0 2. 7 2. 6 2. 5 2. 6 2. 7 2. 8 2. 7 2. 2 2. 8 2. 4 2. 7 2. 4 Company Sanitized. Does not contain TSCA C8I -468- } H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Male, V - 100 mg/kg/day 646349 2.6 2.6 646463 2.7 2.7 646456 3.0 3.0 646469 2.8 2.8 646472 2.4 2.4 646385 2.8 2.8 646373 3.1 3.1 646435 2.7 2.7 646488 2.7 2.7 646455 2.8 2.8 646335 2.8 2.8 646477 2.5 2.5 646327 2.6 2.6 646403 2.5 2.5 646353 2.5 2.5 646341 2.8 2.8 646356 2.9 2.9 646330 2.8 2.8 646499 2.9 2.9 646400 2.8 2.8 646417 2.6 2.6 646338 2.6 2.6 646394 3.0 3.0 646387 2.7 2.7 646447 2.6 2.6 646336 2.5 2.5 646366 2.6 2.6 646496 2.7 2.7 646375 2.8 2.8 646465 2.7 2.7 646390 2.2 2.2 646429 2.8 2.8 646476 2.4 2.4 646348 2.7 2.7 646376 2.4 2.4 Day 26 2.6 2.7 3.0 2.8 2.4 2.8 3.1 2.7 2.7 2.8 2.8 2.5 2.6 2.5 2.5 2.8 2.9 2.8 2.9 2.8 2.6 2.6 3.0 2.7 2.6 2.5 2.6 2.7 2.8 2.7 2.2 2.8 2.4 2.7 2.4 Day 27 2.6 2.7 3.0 2.8 2.4 2.8 3.1 2.7 2.7 2.8 2.8 2.5 2.6 2.5 2.5 2.8 2.9 2.8 2.9 2.8 2.6 2.6 3.0 2.7 2.6 2.5 2.6 2.7 2.8 2.7 2.2 2.8 2.4 2.7 2.4 Day 28 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 29 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 30 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 31 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 32 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 33 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 34 2.8 2.9 3.2 3.0 2.6 3.1 3.5 3.0 3.1 3.1 3.1 2.8 2.7 2.7 2.8 3.1 3.2 3.1 3.3 3.1 2.9 2.9 3.2 2.9 2.8 2.5 2.9 3.0 3.0 3.0 2.5 3.1 2.7 2.9 2.6 Day 35 3.1 3.0 3.4 3.2 2.8 3.3 3.8 3.2 3.4 3.3 3.3 3.1 2.9 2.9 3.0 3.3 3.4 3.3 3.6 3.3 3.0 3.0 3.5 3.2 3.0 2.7 3.1 3.2 3.2 3.2 2.7 3.4 2.9 3.1 2.8 Company Sanitized. Does not contain TSCA CBI -469- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Male, V - 100 mg/kg/day 646349 3.1 3.1 646463 3.0 3.0 646456 3.4 3.4 646469 3.2 3.2 646472 2.8 2.8 646385 3.3 3.3 646373 3.8 3.8 646435 3.2 3.2 646488 3.4 3.4 646455 3.3 3.3 646335 3.3 3.3 646477 3.1 3.1 646327 2.9 2.9 646403 2.9 2.9 646353 3.0 3.0 646341 3.3 3.3 646356 3.4 3.4 646330 3.3 3.3 646499 3.6 3.6 646400 3.3 3.3 646417 3.0 3.0 646338 3.0 3.0 646394 3.5 3.5 646387 3.2 3.2 646447 3.0 3.0 646336 2.7 2.7 646366 3.1 3.1 646496 3.2 3.2 646375 3.2 3.2 646465 3.2 3.2 646390 2.7 2.7 646429 3.4 3.4 646476 2.9 2.9 646348 3.1 3.1 646376 2.8 2.8 Day 38 3.1 3.0 3.4 3.2 2.8 3.3 3.8 3.2 3.4 3.3 3.3 3.1 2.9 2.9 3.0 3.3 3.4 3.3 3.6 3.3 3.0 3.0 3.5 3.2 3.0 2.7 3.1 3.2 3.2 3.2 2.7 3.4 2.9 3.1 2.8 Day 39 3.1 3.0 3.4 3.2 2.8 3.3 3.8 3.2 3.4 3.3 3.3 3.1 2.9 2.9 3.0 3.3 3.4 3.3 3.6 3.3 3.0 3.0 3.5 3.2 3.0 2.7 3.1 3.2 3.2 3.2 2.7 3.4 2.9 3.1 2.8 Day 40 3.1 3.0 3.4 3.2 2.8 3.3 3.8 3.2 3.4 3.3 3.3 3.1 2.9 2.9 3.0 3.3 3.4 3.3 3.6 3.3 3.0 3.0 3.5 3.2 3.0 2.7 3.1 3.2 3.2 3.2 2.7 3.4 2.9 3.1 2.8 Day 41 3.1 3.0 3.4 3.2 2.8 3.3 3.8 3.2 3.4 3.3 3.3 3.1 2.9 2.9 3.0 3.3 3.4 3.3 3.6 3.3 3.0 3.0 3.5 3.2 3.0 2.7 3.1 3.2 3.2 3.2 2.7 3.4 2.9 3.1 2.8 Day 42 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Day 43 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Day 44 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Day 45 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Day 46 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Day 47 3.2 3.1 3.4 3.3 2.9 3.4 3.9 3.3 3.4 3.4 3.6 3.3 3.2 3.0 3.3 3.5 3.4 3.4 3.7 3.4 3.2 3.3 3.8 3.3 3.2 3.0 3.4 3.5 3.5 3.4 2.9 3.6 3.1 3.3 2.9 Company Sanitized. Does not contain TSCA CBI -470- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Male, V - 100 mg/kg/day 646349 3.2 3.4 646463 3.1 3.2 646456 3.4 3.6 646469 3.3 3.5 646472 2.9 3.1 646385 3.4 3.5 646373 3.9 4.2 646435 3.3 3.5 646488 3.4 3.6 646455 3.4 3.5 646335 3.6 3.8 646477 3.3 3.5 646327 3.2 3.3 646403 3.0 3.1 646353 3.3 3.5 646341 3.5 3.8 646356 3.4 3.6 646330 3.4 3.6 646499 3.7 3.8 646400 3.4 3.6 646417 3.2 3.4 646338 3.3 3.4 646394 3.8 4.0 646387 3.3 3.5 646447 3.2 3.4 646336 3.0 3.1 646366 3.4 3.5 646496 3.5 3.6 646375 3.5 3.7 646465 3.4 3.6 646390 2.9 3.2 646429 3.6 3.8 646476 3.1 3.2 646348 3.3 3.4 646376 2.9 3.1 Day 50 3.4 3.2 3.6 3.5 3.1 3.5 4.2 3.5 3.6 3.5 3.8 3.5 3.3 3.1 3.5 3.8 3.6 3.6 3.8 3.6 3.4 3.4 4.0 3.5 3.4 3.1 3.5 3.6 3.7 3.6 3.2 3.8 3.2 3.4 3.1 Day 51 Day 52 3.4 3.4 3.2 3.2 3.6 3.6 3.5 3.5 3.1 3.1 3.5 3.5 4.2 4.2 3.5 3.5 3.6 3.6 3.5 3.5 3.8 3.8 FD TEST DAY 51 3.3 3.3 3.1 3.1 3.5 3.5 3.8 3.8 3.6 3.6 3.6 3.6 3.8 3.8 3.6 3.6 3.4 3.4 3.4 3.4 4.0 4.0 3.5 3.5 3.4 3.4 3.1 3.1 3.5 3.5 3.6 3.6 3.7 3.7 3.6 3.6 3.2 3.2 3.8 3.8 3.2 3.2 3.4 3.4 3.1 3.1 Day 53 3.4 3.2 3.6 3.5 3.1 3.5 4.2 3.5 3.6 3.5 3.8 3.3 3.1 3.5 3.8 3.6 3.6 3.8 3.6 3.4 3.4 4.0 3.5 3.4 3.1 3.5 3.6 3.7 3.6 3.2 3.8 3.2 3.4 3.1 Day 54 3.4 3.2 3.6 3.5 3.1 3.5 4.2 3.5 3.6 3.5 3.8 3.3 3.1 3.5 3.8 3.6 3.6 3.8 3.6 3.4 3.4 4.0 3.5 3.4 3.1 3.5 3.6 3.7 3.6 3.2 3.8 3.2 3.4 3.1 Day 55 3.4 3.2 3.6 3.5 3.1 3.5 4.2 3.5 3.6 3.5 3.8 3.3 3.1 3.5 3.8 3.6 3.6 3.8 3.6 3.4 3.4 4.0 3.5 3.4 3.1 3.5 3.6 3.7 3.6 3.2 3.8 3.2 3.4 3.1 Day 56 3.6 3.3 3.8 3.6 3.2 3.7 4.3 3.6 3.7 3.6 3.9 3.4 3.2 3.5 3.8 3.8 3.7 3.9 3.7 3.5 3.6 4.1 3.6 3.6 3.3 3.7 3.7 3.8 3.7 3.3 4.0 3.3 3.5 3.2 Day 57 3.6 3.3 3.8 3.6 3.2 3.7 4.3 3.6 3.7 3.6 3.9 3.4 3.2 3.5 3.8 3.8 3.7 3.9 3.7 3.5 3.6 4.1 3.6 3.6 3.3 3.7 3.7 3.8 3.7 3.3 4.0 3.3 3.5 3.2 Day 58 3.6 3.3 3.8 3.6 3.2 3.7 4.3 3.6 3.7 3.6 3.9 3.4 3.2 3.5 3.8 3.8 3.7 3.9 3.7 3.5 3.6 4.1 3.6 3.6 3.3 3.7 3.7 3.8 3.7 3.3 4.0 3.3 3.5 3.2 Day 59 3.6 3.3 3.8 3.6 3.2 3.7 4.3 3.6 3.7 3.6 3.9 3.4 3.2 3.5 3.8 3.8 3.7 3.9 3.7 3.5 3.6 4.1 3.6 3.6 3.3 3.7 3.7 3.8 3.7 3.3 4.0 3.3 3.5 3.2 Company Sanitized. Does not contain TSCA CBI -471- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Male, V - 100 mg/kg/day 646349 3.6 3.6 646463 3.3 3.3 646456 3.8 3.8 646469 3.6 3.6 646472 3.2 3.2 646385 3.7 3.7 646373 4.3 4.3 646435 3.6 3.6 646488 3.7 3.7 646455 3.6 3.6 646335 3.9 3.9 646477 646327 3.4 3.4 646403 3.2 3.2 646353 3.5 3.5 646341 3.8 3.8 646356 3.8 3.8 646330 3.7 3.7 646499 3.9 3.9 646400 3.7 3.7 646417 3.5 3.5 646338 3.6 3.6 646394 4.1 4.1 646387 3.6 3.6 646447 3.6 3.6 646336 3.3 3.3 646366 3.7 3.7 646496 3.7 3.7 646375 3.8 3.8 646465 3.7 3.7 646390 3.3 3.3 646429 4.0 4.0 646476 3.3 3.3 646348 3.5 3.5 646376 3.2 3.2 Day 62 3.6 3.3 3.8 3.6 3.2 3.7 4.3 3.6 3.7 3.6 3.9 3.4 3.2 3.5 3.8 3.8 3.7 3.9 3.7 3.5 3.6 4.1 3.6 3.6 3.3 3.7 3.7 3.8 3.7 3.3 4.0 3.3 3.5 3.2 Day 63 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 64 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 65 Day 66 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0, 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 67 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 68 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 69 3.8 3.4 3.9 3.7 3.3 3.8 4.4 3.8 3.8 3.7 4.0 3.4 3.4 3.7 4.0 4.0 3.8 4.0 3.9 3.6 3.7 4.2 3.7 3.8 3.4 3.7 3.8 3.9 3.7 3.5 4.1 3.4 3.6 3.3 Day 70 3.9 3.5 4.0 3.8 3.4 4.0 4.6 3.9 4.0 3.9 4.2 3.6 3.5 3.8 4.1 4.1 3.9 4.1 4.0 3.7 3.8 4.4 3.8 3.9 3.6 3.9 3.9 4.1 3.9 3.5 4.2 3.6 3.7 3.3 Day 7: 39 35 40 38 34 40 46 39 40 39 42 36 35 33 Company Sanitized. Does not contain TSCA CBI -472- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Male, V - 100 mg/kg/day 646349 3.9 3.9 646463 3.5 3.5 646456 4.0 4.0 646469 3.8 3.8 646472 3.4 3.4 646385 4.0 4.0 646373 4.6 4.6 646435 3.9 3.9 646488 4.0 4.0 646455 3.9 3.9 646335 4.2 4.2 646477 646327 3.6 3.6 646403 3.5 3.5 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 3.3 3.3 Day 74 3.9 3.5 4.0 3.8 3.4 4.0 4.6 3.9 4.0 3.9 4.2 3.6 3.5 3.3 Day 75 3.9 3.5 4.0 3.8 3.4 4.0 4.6 3.9 4.0 3.9 4.2 3.6 3.5 3.3 Day 76 3.9 3.5 4.0 3.8 3.4 4.0 4.6 3.9 4.0 3.9 4.2 3.6 3.5 3.3 Day 77 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 Day 78 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 Day 79 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 Day 80 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 Day 81 Day 82 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 c 4.4 3.6 3.6 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 3.4 Day 83 4.0 3.4 4.1 3.8 3.4 4.2 4.7 4.1 4.0 3.9 4.4 3.6 3.6 3.4 Company Sanitized. Does not contain TSCA CBI -473- )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________ INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Male, V - 100 mg/kg/day 646349 4.1 4.1 646463 3.5 3.5 646456 4.1 4.1 646469 3.9 3.9 646472 3.5 3.5 646385 4.2 4.2 646373 4.8 4.8 646435 4.2 4.2 646488 4.1 4.1 646455 4.0 4.0 646335 4.5 4.5 646477 646327 3.7 3.7 646403 3.7 3.7 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 3.4 3.4 Day 86 4.1 3.5 4.1 3.9 3.5 4.2 4.8 4.2 4.1 4.0 4.5 3.7 3.7 3.4 Day 87 4.1 3.5 4.1 3.9 3.5 4.2 4.8 4.2 4.1 4.0 4.5 3.7 3.7 3.4 Day 88 4.1 3.5 4.1 3.9 3.5 4.2 4.8 4.2 4.1 4.0 4.5 3.7 3.7 3.4 Day 89 4.1 3.5 4.1 3.9 3.5 4.2 4.8 4.2 4.1 4.0 4.5 3.7 3.7 3.4 Day 90 4.1 3.5 4.1 3.9 3.5 4.2 4.8 4.2 4.1 4.0 4.5 3.7 3.7 3.4 Day 91 4.1 3.5 4.1 4.0 3.5 4.2 4.9 4.2 4.1 3.9 Day 92 4.1 3.5 4.1 4.0 3.5 4.2 4.9 4.2 4.1 3.9 Day 93 4.1 3.5 4.1 4.0 3.5 4.2 4.9 4.2 4.1 3.9 Day 94 4.1 3.5 4.1 4.0 3.5 4.2 4.9 4.2 4.1 3.9 ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI -474- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Male, VII - 500 mg/kg/day 646475 1.5 1.5 646388 1.7 1.7 646346 1.8 1.8 646433 1.6 1.6 646407 1.7 1.7 646437 1.6 1.6 646343 1.7 1.7 646347 1.6 1.6 646442 1.7 1.7 646413 1.6 1.6 646355 1.7 1.7 646344 1.6 1.6 646466 1.6 1.6 646391 1.5 1.5 646361 1.5 1.5 646382 1.6 1.6 646406 1.6 1.6 646491 1.4 1.4 646351 1.8 1.8 646405 1.7 1.7 646418 1.6 1.6 646362 1.5 1.5 646497 1.6 1.6 646401 1.6 1.6 646422 1.7 1.7 646498 1.7 1.7 646386 1.8 1.8 646332 1.6 1.6 646441 1.7 1.7 646452 1.5 1.5 646365 1.6 1.6 646393 1.6 1.6 646359 1.7 1.7 646380 1.6 1.6 646451 1.6 1.6 646364 1.6 1.6 646384 1.7 1.7 646474 1.5 1.5 646448 1.6 1.6 646484 1.6 1.6 646337 1.7 1.7 646428 1.5 1.5 646369 1.4 1.4 646397 1.6 1.6 646372 1.7 1.7 Day 2 1.5 1.7 1.8 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1-7 1.6 1.6 1.5 1.5 1.6 1.6 1.4 1.8 1.7 1.6 1.5 1.6 1.6 1.7 1.7 1.8 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.5 1.4 1.6 1.7 Day 3 1.5 1.7 1.8 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.6 1.5 1.5 1.6 1.6 1.4 1.8 1.7 1.6 1.5 1.6 1.6 1.7 1.7 1.8 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.5 1.4 1.6 1.7 Day 4 1.5 .1.7 1.8 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.6 1.5 1.5 1.6 1.6 1.4 1.8 1.7 1.6 1.5 1.6 1.6 1.7 1.7 1.8 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.5 1.4 1.6 1.7 Day 5 1.5 1.7 1.8 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.6 1.5 1.5 1.6 1.6 1.4 1.8 1.7 1.6 1.5 1.6 1.6 1.7 1.7 1.8 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.5 1.4 1.6 1.7 Day 6 1.5 1.7 1.8 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.7 1.6 1.6 1.5 1.5 1.6 1.6 1.4 1.8 1.7 1.6 1.5 1.6 1.6 1.7 1.7 1.8 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.5 1.4 1.6 1.7 Day 7 1.7 1.8 2.0 1.8 1.9 1.6 1.9 1.7 1.8 1.8 1.8 1.7 1.8 1.6 1.6 1.6 1.8 1.8 2.0 1.8 1.8 1.7 1.9 1.8 1.8 1.9 2.1 1.7 1.9 1.7 1.8 1.8 1.9 1.8 1.8 1.7 1.8 1.5 1.8 1.8 1.8 1.5 1.6 1.9 1.9 Day 8 1.7 1.8 2.0 1.8 1.9 1.6 1.9 1.7 1.8 1.8 1.8 1.7 1.8 1.6 1.6 1.6 1.8 1.8 2.0 1.8 1.8 1.7 1.9 1.8 1.8 1.9 2.1 1.7 1.9 1.7 1.8 1.8 1.9 1.8 1.8 1.7 1.8 1.5 1.8 1.8 1.8 1.5 1.6 1.9 1.9 Day 9 1.7 1.8 2.0 1.8 1.9 1.6 1.9 1.7 1.8 1.8 1.8 1.7 1.8 1.6 1.6 1.6 1.8 1.8 2.0 1.8 1.8 1.7 1.9 1.8 1.8 1.9 2.1 1.7 1.9 1.7 1.8 1.8 1.9 1.8 1.8 1.7 1.8 1.5 1.8 1.8 1.8 1.5 1.6 1.9 1.9 Day 10 1.7 1.8 2.0 1.8 1.9 1.6 1.9 1.7 1.8 1.8 1.8 1.7 1.8 1.6 1.6 1.6 1.8 1.8 2.0 1.8 1.8 1.7 1.9 1.8 1.8 1.9 2.1 1.7 1.9 1.7 1.8 1.8 1.9 1.8 1.8 1.7 1.8 1.5 1.8 1.8 1.8 1.5 1.6 1.9 1.9 Day 11 1.7 1.8 2.0 1.8 1.9 1.6 1.9 1.7 1.8 1.8 1.8 1.7 1.8 1.6 1.6 1.6 1.8 1.8 2.0 1.8 1.8 1.7 1.9 1.8 1.8 1.9 2.1 1.7 1.9 1.7 1.8 1.8 1.9 1.8 1.8 1.7 1.8 1.5 1.8 1.8 1.8 1.5 1.6 1.9 1.9 - 475' )) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Male, Vii - 500 mg/kg/day 646475 1.7 1.7 646388 1.8 1.8 646346 2.0 2.0 646433 1.8 1.8 646407 1.9 1.9 646437 1.6 1.6 646343 1.9 1.9 646347 1.7 1.7 646442 1.8 1.8 646413 1.8 1.8 646355 1.8 1.8 646344 1.7 1.7 646466 1.8 1.8 646391 1.6 1.6 646361 1.6 1.6 646382 1.6 1.6 646406 1.8 1.8 646491 1.8 1.8 646351 2.0 2.0 646405 1.8 1.8 646418 1.8 1.8 646362 1.7 1.7 646497 1.9 1.9 646401 1.8 1.8 646422 1.8 1.8 646498 1.9 1.9 646386 2.1 2.1 646332 1.7 1.7 646441 1.9 1.9 646452 1.7 1.7 646365 1.8 1.8 646393 1.8 1.8 646359 1.9 1.9 646380 1.8 1.8 646451 1.8 1.8 646364 1.7 1.7 646384 1.8 1.8 646474 1.5 1.5 646448 1.8 1.8 646484 1.8 1.8 646337 1.8 1.8 646428 1.5 1.5 646369 1.6 1.6 646397 1.9 1.9 646372 1.9 1.9 Day 14 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 15 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 16 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 17 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 18 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 19 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 20 2.0 2.3 2.4 2.1 2.4 2.0 2.2 2.1 2.1 2.2 2.2 2.0 2.2 2.0 1.8 1.9 2.2 2.3 2.4 2.3 2.3 2.0 2.2 2.2 2.2 2.4 2.6 2.0 2.4 1.9 2.2 2.3 2.3 2.2 2.1 2.0 2.2 2.0 2.2 2.1 2.2 1.9 1.9 2.3 2.2 Day 21 2.3 2.9 2.7 2.4 2.7 2.2 2.5 2.3 2.4 2.5 2.5 2.3 2.6 2.3 2.1 2.2 2.5 2.6 2.7 2.5 2.6 2.1 2.5 2.6 2.6 2.8 3.1 2.1 2.6 2.3 2.5 2.6 2.7 2.6 2.4 2.1 2.6 2.1 2.5 2.4 2.5 2.3 2.1 2.6 2.4 Day 22 2.3 2.9 2.7 2.4 2.7 2.2 2.5 2.3 2.4 2.5 2.5 2.3 2.6 2.3 2.1 2.2 2.5 2.6 2.7 2.5 2.6 2.1 2.5 2.6 2.6 2.8 3.1 2.1 2.6 2.3 2.5 2.6 2.7 2.6 2.4 2.1 2.6 2.1 2.5 2.4 2.5 2.3 2.1 2.6 2.4 Day 23 2.3 2.9 2.7 2.4 2.7 2.2 2.5 2.3 2.4 2.5 2.5 2.3 2.6 2.3 2.1 2.2 2.5 2.6 2.7 2.5 2.6 2.1 2.5 2.6 2.6 2.8 3.1 2.1 2.6 2.3 2.5 2.6 2.7 2.6 2.4 2.1 2.6 2.1 2.5 2.4 2.5 2.3 2.1 2.6 2.4 -476- ) H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 Company Sanitized. Does not contain TSCA C8I INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Male, VII - 500 mg/kg/day 646475 2.3 2.3 646388 2.9 2.9 646346 2.7 2.7 646433 2.4 2.4 646407 2.7 2.7 646437 2.2 2.2 646343 2.5 2.5 646347 2.3 2.3 646442 2.4 2.4 646413 2.5 2.5 646355 2.5 2.5 646344 2.3 2.3 646466 2.6 2.6 646391 2.3 2.3 646361 2.1 2.1 646382 2.2 2.2 646406 2.5 2.5 646491 2.6 2.6 646351 2.7 2.7 646405 2.5 2.5 646418 2.6 2.6 646362 2.1 2.1 646497 2.5 2.5 646401 2.6 2.6 646422 2.6 2.6 646498 2.8 2.8 646386 3.1 3.1 646332 2.1 2.1 646441 2.6 2.6 646452 2.3 2.3 646365 2.5 2.5 646393 2.6 2.6 646359 2.7 2.7 646380 2.6 2.6 646451 2.4 2.4 646364 2.1 2.1 646384 2.6 2.6 646474 2.1 2.1 646448 2.5 2.5 646484 2.4 2.4 646337 2.5 2.5 646428 2.3 2.3 646369 2.1 2.1 646397 2.6 2.6 646372 2.4 2.4 Day 26 2.3 2.9 2.7 2.4 2.7 2.2 2.5 2.3 2.4 2.5 2.5 2.3 2.6 2.3 2.1 2.2 2.5 2.6 2.7 2.5 2.6 2.1 2.5 2.6 2.6 2.8 3.1 2.1 2.6 2.3 2.5 2.6 2.7 2.6 2.4 2.1 2.6 2.1 2.5 2.4 2.5 2.3 2.1 2.6 2.4 Day 27 2.3 2.9 2.7 2.4 2.7 2.2 2.5 2.3 2.4 2.5 2.5 2.3 2.6 2.3 2.1 2.2 2.5 2.6 2.7 2.5 2.6 2.1 2.5 2.6 2.6 2.8 3.1 2.1 2.6 2.3 2.5 2.6 2.7 2.6 2.4 2.1 2.6 2.1 2.5 2.4 2.5 2.3 2.1 2.6 2.4 Day 28 2.6 3.2 2.9 2.5 2.9 2.5 2.7 2.6 2.6 2.7 2.7 2.4 2.9 2.5 2.3 2.4 2.7 3.0 2.9 2.7 2.8 2.3 2.7 2.9 2.9 3.1 3.4 2.3 2.9 2.5 2.8 2.9 2.8 2.9 2.5 2.2 2.9 2.3 2.7 2.6 2.7 2.6 2.4 2.8 2.6 Day 29 Day 30 2.6 2.6 3.2 3.2 2.9 2.9 2.5 2.5 2.9 2.9 2.5 2.5 2.7 2.7 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.4 2.4 2.9 2.9 2.5 2.5 2.3 2.3 2.4 2.4 2.7 2.7 3.0 3.0 2.9 2.9 2.7 2.7 2.8 2.8 2.3 2.3 2.7 2.7 2.9 2.9 SE TEST DAY 28 3.1 3.1 3.4 3.4 2.3 2.3 2.9 2.9 2.5 2.5 2.8 2.8 2.9 2.9 2.8 2.8 2.9 2.9 2.5 2.5 2.2 2.2 2.9 2.9 2.3 2.3 2.7 2.7 2.6 2.6 2.7 2.7 2.6 2.6 2.4 2.4 2.8 2.8 2.6 2.6 Day 31 Day 32 2.6 2.6 3.2 3.2 2.9 2.9 2.5 2.5 2.9 2.9 2.5 2.5 2.7 2.7 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.4 2.4 2.9 2.9 2.5 2.5 2.3 2.3 2.4 2.4 2.7 2.7 3.0 3.0 2.9 2.9 2.7 2.7 2.8 2.8 2.3 2.3 2.7 2.7 2.9 2.9 3.1 3.1 3.4 3.4 2.3 2.3 2.9 2.9 2.5 2.5 2.8 2.8 2.9 2.9 2.8 2.8 FD TEST DAY 31 2.5 2.5 2.2 2.2 2.9 2.9 2.3 2.3 2.7 2.7 2.6 2.6 2.7 2.7 2.6 2.6 2.4 2.4 2.8 2.8 2.6 2.6 Day 33 2.6 3.2 2.9 2.5 2.9 2.5 2.7 2.6 2.6 2.7 2.7 2.4 2.9 2.5 2.3 2.4 2.7 3.0 2.9 2.7 2.8 2.3 2.7 2.9 3.1 3.4 2.3 2.9 2.5 2.8 2.9 2.8 2.5 2.2 2.9 2.3 2.7 2.6 2.7 2.6 2.4 2.8 2.6 Day 34 2.6 3.2 2.9 2.5 2.9 2.5 2.7 2.6 2.6 2.7 2.7 2.4 2.9 2.5 2.3 2.4 2.7 3.0 2.9 2.7 2.8 2.3 2.7 2.9 3.1 3.4 2.3 2.9 2.5 2.8 2.9 2.8 2.5 2.2 2.9 2.3 2.7 2.6 2.7 2.6 2.4 2.8 2.6 Day 35 2.7 3.3 3.1 2.7 3.1 2.6 2.8 2.6 2.7 2.7 2.8 2.5 3.0 2.7 2.5 2.6 2.9 3.1 3.0 2.8 3.0 2.4 2.8 3.0 3.3 3.6 2.3 3.0 2.7 2.9 3.0 3.0 2.7 2.4 3.1 2.4 2.7 2.8 2.9 2.8 2.5 3.0 2.7 -477- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) DuPont-5990 Company Sanitized. Does not contain TSCA CBI Male, VII - 500 mg/kg/day 646475 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 646388 3.3 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 646346 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 646433 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 646407 3.1 3.1 3.1 3.1 3.1 3.1 3.2 3.2 3.2 3.2 3.2 3.2 646437 2.6 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.7 646343 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 646347 2.6 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.7 646442 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 646413 2.7 2.7 2.7 2.7 2.7 2.7 2.6 2.6 2.6 2.6 2.6 2.6 646355 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 646344 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 646466 3.0 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.1 646391 2.7 2.7 2.7 2.7 2.7 2.7 2.9 2.9 2.9 2.9 2.9 2.9 646361 2.5 2.5 2.5 2.5 2.5 2.5 2.7 2.7 2.7 2.7 2.7 2.7 646382 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.8 2.8 2.8 2.8 646406 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 646491 3.1 3.1 3.1 3.1 3.1 3.1 3.3 3.3 3.3 3.3 3.3 3.3 646351 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 3.2 646405 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 646418 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 3.2 646362 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.6 2.6 646497 2.8 2.8 2.8 2.8 2.8 2.8 3.0 3.0 3.0 3.0 3.0 3.0 646401 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 3.2 646422 646498 3.3 3.3 3.3 3.3 3.3 3.3 3.5 3.5 3.5 3.5 3.5 3.5 646386 3.6 3.6 3.6 3.6 3.6 3.6 3.9 3.9 3.9 3.9 3.9 3.9 646332 2.3 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.4 646441 3.0 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.1 646452 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 646365 2.9 2.9 2.9 2.9 2.9 2.9 3.0 3.0 3.0 3.0 3.0 3.0 646393 3.0 3.0 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 3.3 3.3 646359 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 3.2 646380 646451 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 646364 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.5 646384 3.1 3.1 3.1 3.1 3.1 3.1 3.4 3.4 3.4 3.4 3.4 3.4 646474 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.5 646448 2.7 2.7 2.7 2.7 2.7 2.7 2.9 2.9 2.9 2.9 2.9 2.9 646484 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 646337 2.9 2.9 2.9 2.9 2.9 2.9 3.1 3.1 3.1 3.1 3.1 3.1 646428 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 646369 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 646397 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.2 3.2 646372 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.8 )) ) H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Male, VII - 500 mg/kg/day 646475 2.7 2.8 646388 3.4 3.6 646346 3.1 3.4 646433 2.7 2.8 646407 3.2 3.4 646437 2.7 2.8 646343 2.9 3.1 646347 2.7 2.8 646442 2.8 2.8 646413 2.6 2.8 646355 2.9 2.9 646344 2.6 2.8 646466 3.1 3.3 646391 2.9 3.0 646361 2.7 2.9 646382 2.8 2.9 646406 2.9 3.1 646491 3.3 3.4 646351 3.2 3.2 646405 2.9 2.9 646418 3.2 3.3 646362 2.6 2.7 646497 3.0 3.1 646401 3.2 3.2 646422 646498 3.5 3.7 646386 3.9 4.0 646332 2.4 2.5 646441 3.1 3.3 646452 2.8 2.8 646365 3.0 3.2 646393 3.3 3.4 646359 3.2 3.4 646380 646451 2.8 2.9 646364 2.5 2.5 646384 3.4 3.5 646474 2.5 2.6 646448 2.9 3.2 646484 2.9 3.1 646337 3.1 3.3 646428 2.9 3.0 646369 2.6 2.8 646397 3.2 3.3 646372 2.8 2.9 Day 50 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 51 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 52 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 53 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 54 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 55 2.8 3.6 3.4 2.8 3.4 2.8 3.1 2.8 2.8 2.8 2.9 2.8 3.3 3.0 2.9 2.9 3.1 3.4 3.2 2.9 3.3 2.7 3.1 3.2 3.7 4.0 2.5 3.3 2.8 3.2 3.4 3.4 2.9 2.5 3.5 2.6 3.2 3.1 3.3 3.0 2.8 3.3 2.9 Day 56 3.0 3.7 3.5 2.9 3.6 3.0 3.2 2.9 3.0 2.9 3.1 2.9 3.4 3.2 3.0 3.0 3.3 3.5 3.4 3.1 3.5 2.8 3.2 3.5 3.9 4.0 2.6 3.3 3.0 3.3 3.4 3.6 3.0 2.6 3.8 2.8 3.2 3.2 3.4 3.2 2.9 3.4 3.0 Day 57 3.0 3.7 3.5 2.9 3.6 3.0 3.2 2.9 3.0 2.9 3.1 2.9 3.4 3.2 3.0 3.0 3.3 3.5 3.4 3.1 3.5 2.8 3.2 3.5 3.9 4.0 2.6 3.3 3.0 3.3 3.4 3.6 3.0 2.6 3.8 2.8 3.2 3.2 3.4 3.2 2.9 3.4 3.0 Day 58 3.0 3.7 3.5 2.9 3.6 3.0 3.2 2.9 3.0 2.9 3.1 2.9 3.4 3.2 3.0 3.0 3.3 3.5 3.4 3.1 3.5 2.8 3.2 3.5 3.9 4.0 2.6 3.3 3.0 3.3 3.4 3.6 3.0 2.6 3.8 2.8 3.2 3.2 3.4 3.2 2.9 3.4 3.0 Day 59 3.0 3.7 3.5 2.9 3.6 3.0 3.2 2.9 3.0 2.9 3.1 2.9 3.4 3.2 3.0 3.0 3.3 3.5 3.4 3.1 3.5 2.8 3.2 3.5 3.9 4.0 2.6 3.3 3.0 3.3 3.4 3.6 3.0 2.6 3.8 2.8 3.2 3.2 3.4 3.2 2.9 3.4 3.0 -479- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Male, VII - 500 mg/kg/day 646475 3.0 3.0 646388 3.7 3.7 646346 3.5 3.5 646433 2.9 2.9 646407 3.6 3.6 646437 3.0 3.0 646343 3.2 3.2 646347 2.9 2.9 646442 3.0 3.0 646413 2.9 2.9 646355 3.1 3.1 646344 2.9 2.9 646466 3.4 3.4 646391 3.2 3.2 646361 3.0 3.0 646382 3.0 3.0 646406 3.3 3.3 646491 3.5 3.5 646351 3.4 3.4 646405 3.1 3.1 646418 3.5 3.5 646362 2.8 2.8 646497 3.2 3.2 646401 3.5 3.5 646422 646498 3.9 3.9 646386 4.0 4.0 646332 2.6 2.6 646441 3.3 3.3 646452 3.0 3.0 646365 3.3 3.3 646393 3.4 3.4 646359 3.6 3.6 646380 646451 3.0 3.0 646364 2.6 2.6 646384 3.8 3.8 646474 2.8 2.8 646448 3.2 3.2 646484 3.2 3.2 646337 3.4 3.4 646428 3.2 3.2 646369 2.9 2.9 646397 3.4 3.4 646372 3.0 3.0 Day 62 3.0 3.7 3.5 2.9 3.6 3.0 3.2 2.9 3.0 2.9 3.1 2.9 3.4 3.2 3.0 3.0 3.3 3.5 3.4 3.1 3.5 2.8 3.2 3.5 3.9 4.0 2.6 3.3 3.0 3.3 3.4 3.6 3.0 2.6 3.8 2.8 3.2 3.2 3.4 3.2 2.9 3.4 3.0 Day 63 Day 64 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 c 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 Day 65 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 Day 66 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 Day 67 Day 68 3.1 3.8 3.7 3.0 3.7 3.2 3.4 ' 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 Day 69 3.1 3.8 3.7 3.0 3.7 3.2 3.4 3.1 3.1 3.0 3.2 3.0 3.5 3.2 3.1 3.0 3.4 3.7 3.4 3.2 3.5 2.9 3.3 3.7 3.9 4.2 2.7 3.5 3.1 3.4 3.5 3.6 3.0 2.8 3.9 2.8 3.3 3.3 3.5 3.3 3.0 3.6 3.1 Day 70 3.2 3.9 3.8 3.1 3.8 3.3 3.4 3.1 3.1 3.0 3.2 3.1 3.6 3.3 3.3 3.0 3.4 3.8 3.5 3.4 3.5 3.0 3.4 3.9 4.1 4.3 2.8 3.6 3.2 3.4 3.5 3.7 3.0 2.9 3.9 2.8 3.3 3.4 3.5 3.3 3.0 3.7 3.2 Day 71 3.2 3.9 3.8 3.1 3.8 3.3 3.4 3.1 3.1 3.0 3.2 3.1 3.6 3.3 3.3 2.9 3.9 2.8 3.3 3.4 3.5 3.3 3.0 3.7 3.2 -480- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Dav 74 Dav 75 11 = IQ r-.,, IQ Male, VII - 500 mg/kg/day 646475 3.2 3.2 3.2 3.2 3.2 3.3 3.3 3.3 3.3 3.3 3.3 3.3 646388 3.9 3.9 3.9 3.9 3.9 4.0 4.0 4.0 4.0 4.0 4.0 4.0 646346 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 646433 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 646407 3.8 3.8 3.8 3.8 3.8 3.9 3.9 3.9 3.9 3.9 3.9 3.9 646437 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 646343 3.4 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 646347 3.1 3.1 3.1 3.1 3.1 3.2 3.2 3.2 3.2 3.2 3.2 3.2 646442 3.1 3.1 3.1 3.1 3.1 3.2 3.2 3.2 3.2 3.2 3.2 3.2 646413 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.1 3.1 646355 3.2 3.2 3.2 3.2 3.2 3.3 3.3 3.3 3.3 3.3 3.3 3.3 646344 3.1 3.1 3.1 3.1 3.1 3.2 3.2 3.2 3.2 3.2 3.2 3.2 646466 3.6 3.6 3.6 3.6 3.6 3.5 3.5 3.5 3.5 3.5 3.5 3.5 646391 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 646361 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 2.9 2.9 2.9 2.9 2.9 3.0 3.0 3.0 3.0 3.0 3.0 3.0 646384 3.9 3.9 3.9 3.9 3.9 4.0 4.0 4.0 4.0 4.0 4.0 4.0 646474 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.9 2.9 646448 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 646484 3.4 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 646337 3.5 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 3.7 646428 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.4 3.4 646369 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.1 3.1 646397 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 646372 3.2 3.2 3.2 3.2 3.2 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Company Sanitized. Does not contain TSCA CBI -481- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Male, Vii - 500 mg/kg/day 646475 3.3 3.3 646388 4.1 4.1 646346 3.9 3.9 646433 3.1 3.1 646407 3.9 3.9 646437 3.4 3.4 646343 3.6 3.6 646347 3.2 3.2 646442 3.2 3.2 646413 3.2 3.2 646355 3.4 3.4 646344 3.3 3.3 646466 3.6 3.6 646391 3.5 3.5 646361 3.6 3.6 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 3.0 3.0 646384 4.0 4.0 646474 2.8 2.8 646448 3.5 3.5 646484 3.5 3.5 646337 3.8 3.8 646428 3.5 3.5 646369 3.1 3.1 646397 3.7 3.7 646372 3.2 3.2 Day 86 3.3 4.1 3.9 3.1 3.9 3.4 3.6 3.2 3.2 3.2 3.4 3.3 3.6 3.5 3.6 3.0 4.0 2.8 3.5 3.5 3.8 3.5 3.1 3.7 3.2 Day 87 3.3 4.1 3.9 3.1 3.9 3.4 3.6 3.2 3.2 3.2 3.4 3.3 3.6 3.5 3.6 3.0 4.0 2.8 3.5 3.5 3.8 3.5 3.1 3.7 3.2 Day 88 3.3 4.1 3.9 3.1 3.9 3.4 3.6 3.2 3.2 3.2 3.4 3.3 3.6 3.5 3.6 3.0 4.0 2.8 3.5 3.5 3.8 3.5 3.1 3.7 3.2 Day 89 Day 90 3.3 4.1 3.9 3.1 3.9 3.4 3.6 3.2 3.2 3.2 3.4 . 3.3 3.6 3.5 3.6 3.3 4.1 3.9 3.1 3.9 3.4 3.6 3.2 3.2 3.2 3.4 3.3 3.6 3.5 3.6 3.0 3.0 4.0 4.0 2.8 2.8 3.5 3.5 3.5 3.5 3.8 3.8 3.5 3.5 3.1 3.1 3.7 3.7 3.2 3.2 Day 91 3.5 4.2 4.0 3.2 4.1 3.5 3.6 3.2 3.3 3.3 Day 92 3.5 4.2 4.0 3.2 4.1 3.5 3.6 3.2 3.3 3.3 Day 93 3.5 4.2 4.0 3.2 4.1 3.5 3.6 3.2 3.3 3.3 Day 94 3.5 4.2 4.0 3.2 4.1 3.5 3.6 3.2 3.3 3.3 -482 ) DuPont-5990 H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Female, II - 0 mg/kg/day 646592 1.4 1.4 646560 1.2 1.2 646676 1.5 1.5 646665 1.3 1.3 646612 1.3 1.3 646538 1.4 1.4 646659 1.3 1.3 646649 1.5 1.5 646617 1.3 1.3 646537 1.3 1.3 646642 1.4 1.4 646530 1.3 1.3 646588 1.4 1.4 646597 1.3 1.3 646507 1.3 1.3 646653 1.2 1.2 646575 1.4 1.4 646585 1.2 1.2 646622 1.4 1.4 646550 1.4 1.4 646526 1.2 1.2 646503 1.3 1.3 646644 1.3 1.3 646604 1.3 1.3 646651 1.3 1.3 646552 1.4 1.4 646606 1.1 1.1 646557 1.3 1.3 646591 1.2 1.2 646544 1.4 1.4 646646 1.4 1.4 646520 1.1 1.1 646569 1.3 1.3 646654 1.3 1.3 646668 1.5 1.5 646580 1.2 1.2 646581 1.3 1.3 646627 1.3 1.3 646565 1.3 1.3 646551 1.3 1.3 646511 1.4 1.4 646549 1.4 1.4 646652 1.2 1.2 646586 1.3 1.3 646613 1.3 1.3 Day 2 1.4 1.2 1.5 1.3 1.3 1.4 1.3 1.5 1.3 1.3 1.4 1.3 1.4 1.3 1.3 1.2 1.4 1.2 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.4 1.1 1.3 1.2 1.4 1.4 1.1 1.3 1.3 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.3 1.3 Day 3 1.4 1.2 1.5 1.3 1.3 1.4 1.3 1.5 1.3 1.3 1.4 1.3 1.4 1.3 1.3 1.2 1.4 1.2 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.4 1.1 1.3 1.2 1.4 1.4 1.1 1.3 1.3 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.3 1.3 Day 4 1.4 1.2 1.5 1.3 1.3 1.4 1.3 1.5 1.3 1.3 1.4 1.3 1.4 1.3 1.3 1.2 1.4 1.2 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.4 1.1 1.3 1.2 1.4 1.4 1.1 1.3 1.3 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.3 1.3 Day 5 1.4 1.2 1.5 1.3 1.3 1.4 1.3 1.5 1.3 1.3 1.4 1.3 1.4 1.3 1.3 1.2 1.4 1.2 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.4 1.1 1.3 1.2 1.4 1.4 1.1 1.3 1.3 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.3 1.3 Day 6 1.4 1.2 1.5 1.3 1.3 1.4 1.3 1.5 1.3 1.3 1.4 1.3 1.4 1.3 1.3 1.2 1.4 1.2 1.4 1.4 1.2 1.3 1.3 1.3 1.3 1.4 1.1 1.3 1.2 1.4 1.4 1.1 1.3 1.3 1.5 1.2 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.3 1.3 Day 7 1.6 1.4 1.6 1.4 1.4 1.6 1.5 1.7 1.5 1.5 1.4 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.6 1.3 1.5 1.4 1.5 1.5 1.2 1.5 1.3 1.7 1.4 1.5 1.5 1.5 1.6 1.5 1.5 1.5 1.5 1.4 Day 8 1.6 1.4 1.6 1.4 1.4 1.6 1.5 1.7 1.5 1.5 1.4 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.6 1.3 1.5 1.4 1.5 1.5 1.2 1.5 1.3 1.7 1.4 1.5 1.5 1.5 1.6 1.5 1.5 1.5 1.5 1.4 Day 9 1.6 1.4 1.6 1.4 1.4 1.6 1.5 1.7 1.5 1.5 1.4 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.6 1.3 1.5 1.4 1.5 1.5 1.2 1.5 1.3 1.7 1.4 1.5 1.5 1.5 1.6 1.5 1.5 1.5 1.5 1.4 Day 10 1.6 1.4 1.6 1.4 1.4 1.6 1.5 1.7 1.5 1.5 1.4 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.5 1.4 1.4 1.5 1.4 1.5 1.6 1.3 1.5 1.4 1.5 1.5 1.2 1.5 1.3 1.7 1.4 1.5 1.5 1.5 1.6 1.5 1.5 1.5 1.5 1.4 Day 11 1. 6 1. 4 1. 6 1. 4 1. 4 1. 6 1. 5 1. 7 1. 5 1. 5 1. 4 1. 4 1. 5 1. 5 1. 4 1. 4 1. 5 1. 4 1. 5 1. 5 1. 4 1. 4 1. 5 1. 4 1. 5 1. 6 1. 3 1. 5 1. 4 1. 5 1. 5 1. 2 1. 5 1. 3 1. 7 1. 4 1. 5 1. 5 1. 5 1. 6 1. 5 1. 5 1. 5 1. 5 1. 4 -483- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Female, II - 0 mg/kg/day 646592 1.6 1.6 646560 1.4 1.4 646676 1.6 1.6 646665 1.4 1.4 646612 1.4 1.4 646538 1.6 1.6 646659 1.5 1.5 646649 1.7 1.7 646617 1.5 1.5 646537 1.5 1.5 646642 1.4 1.4 646530 1.4 1.4 646588 1.5 1.5 646597 1.5 1.5 646507 1.4 1.4 646653 1.4 1.4 646575 1.5 1.5 646585 1.4 1.4 646622 1.5 1.5 646550 1.5 1.5 646526 1.4 1.4 646503 1.4 1.4 646644 1.5 1.5 646604 1.4 1.4 646651 1.5 1.5 646552 1.6 1.6 646606 1.3 1.3 646557 1.5 1.5 646591 1.4 1.4 646544 1.5 1.5 646646 1.5 1.5 646520 1.2 1.2 646569 1.5 1.5 646654 1.3 1.3 646668 1.7 1.7 646580 1.4 1.4 646581 1.5 1.5 646627 1.5 1.5 646565 1.5 1.5 646551 1.6 1.6 646511 1.5 1.5 646549 1.5 1.5 646652 1.5 1.5 646586 1.5 1.5 646613 1.4 1.4 Day 14 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 Day 15 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 Day 16 Day 17 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 c 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 Day 18 Day 19 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 x1 .n/ 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 Day 20 1.8 1.4 1.8 1.5 1.5 1.7 1.7 2.0 1.6 1.6 1.6 1.6 1.7 1.6 1.5 1.5 1.7 1.5 1.7 1.7 1.6 1.6 1.7 1.6 1.8 1.7 1.4 1.6 1.4 1.7 1.7 1.3 1.6 1.5 1.9 1.5 1.5 1.6 1.7 1.7 1.8 1.6 1.6 1.7 1.5 Day 21 1.9 1.5 2.1 1.6 1.6 1.9 1.8 2.1 1.8 1.7 1.6 1.6 1.9 1.9 1.7 1.6 2.0 1.6 2.0 1.9 1.7 1.7 1.9 1.7 1.9 1.8 1.5 1.8 1.6 1.9 1.7 1.5 1.8 1.7 2.1 1.7 1.7 1.7 1.8 1.8 2.0 1.8 1.7 1.8 1.7 Day 22 1.9 1.5 2.1 1.6 1.6 1.9 1.8 2.1 1.8 1.7 1.6 1.6 1.9 1.9 1.7 1.6 2.0 1.6 2.0 1.9 1.7 1.7 1.9 1.7 1.9 1.8 1.5 1.8 1.6 1.9 1.7 1.5 1.8 1.7 2.1 1.7 1.7 1.7 1.8 1.8 2.0 1.8 1.7 1.8 1.7 Day 23 1.9 1.5 2.1 1.6 1.6 1.9 1.8 2.1 1.8 1.7 1.6 1.6 1.9 1.9 1.7 1.6 2.0 1.6 2.0 1.9 1.7 1.7 1.9 1.7 1.9 1.8 1.5 1.8 1.6 1.9 1.7 1.5 1.8 1.7 2.1 1.7 1.7 1.7 1.8 1.8 2.0 1.8 1.7 1.8 1.7 Company Sanitized. Does not contain TSCA CBI -484- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Female, II - 0 mg/kg/day 646592 1.9 1.9 646560 1.5 1.5 646676 2.1 2.1 646665 1.6 1.6 646612 1.6 1.6 646538 1.9 1.9 646659 1.8 1.8 646649 2.1 2.1 646617 1.8 1.8 646537 1.7 1.7 646642 1.6 1.6 646530 1.6 1.6 646588 1.9 1.9 646597 1.9 1.9 646507 1.7 1.7 646653 1.6 1.6 646575 2.0 2.0 646585 1.6 1.6 646622 2.0 2.0 646550 1.9 1.9 646526 1.7 1.7 646503 1.7 1.7 646644 1.9 1.9 646604 1.7 1.7 646651 1.9 1.9 646552 1.8 1.8 646606 1.5 1.5 646557 1.8 1.8 646591 1.6 1.6 646544 1.9 1.9 646646 1.7 1.7 646520 1.5 1.5 646569 1.8 1.8 646654 1.7 1.7 646668 2.1 2.1 646580 1.7 1.7 646581 1.7 1.7 646627 1.7 1.7 646565 1.8 1.8 646551 1.8 1.8 646511 2.0 2.0 646549 1.8 1.8 646652 1.7 1.7 646586 1.8 1.8 646613 1.7 1.7 Day 26 1.9 1.5 2.1 1.6 1.6 1.9 1.8 2.1 1.8 1.7 1.6 1.6 1.9 1.9 1.7 1.6 2.0 1.6 2.0 1.9 1.7 1.7 1.9 1.7 1.9 1.8 1.5 1.8 1.6 1.9 1.7 1.5 1.8 1.7 2.1 1.7 1.7 1.7 1.8 1.8 2.0 1.8 1.7 1.8 1.7 Day 27 1.9 1.5 2.1 1.6 1.6 1.9 1.8 2.1 1.8 1.7 1.6 1.6 1.9 1.9 1.7 1.6 2.0 1.6 2.0 1.9 1.7 1.7 1.9 1.7 1.9 1.8 1.5 1.8 1.6 1.9 1.7 1.5 1.8 1.7 2.1 1.7 1.7 1.7 1.8 1.8 2.0 1.8 1.7 1.8 1.7 Day 28 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 29 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 30 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 31 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 32 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 33 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 34 2.0 1.7 2.2 1.6 1.8 2.0 2.0 2.3 1.8 1.9 1.7 1.8 1.9 2.0 1.8 1.8 1.9 1.8 2.1 2.0 1.8 1.8 2.1 1.9 2.0 2.0 1.6 1.8 1.7 2.0 2.0 1.6 1.9 1.8 2.3 1.8 1.8 1.9 2.0 2.0 2.1 1.9 2.0 1.9 1.9 Day 35 2. l 1. 7 2. 3 1. 7 1. 9 2. 1 2. 2 2. 5 2. 0 1. 9 1. 7 1. 9 2. 1 2. 1 1. 8 1. 8 2. 2 1. 8 2. 2 2. 1 1. 9 1. 8 2. 1 1. 9 2. 1 2. 0 1. 6 1. 9 1. 8 2. 2 2. 1 1. 6 2. 1 1. 8 2. 4 1. 9 1. 9 1. 9 2. 2 2. 1 2. 2 2. 0 2. 1 2. 1 1. 9 -485- ))) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations_________________________________________________________________ DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Female, II - 0 mg/kg/day 646592 2.1 2.1 646560 1.7 1.7 646676 2.3 2.3 646665 1.7 1.7 646612 1.9 1.9 646538 2.1 2.1 646659 2.2 2.2 646649 2.5 2.5 646617 2.0 2.0 646537 1.9 1.9 646642 1.7 1.7 646530 1.9 1.9 646588 2.1 2.1 646597 2.1 2.1 646507 1.8 1.8 646653 1.8 1.8 646575 2.2 2.2 646585 1.8 1.8 646622 2.2 2.2 646550 2.1 2.1 646526 1.9 1.9 646503 1.8 1.8 646644 2.1 2.1 646604 1.9 1.9 646651 2.1 2.1 646552 2.0 2.0 646606 1.6 1.6 646557 1.9 1.9 646591 1.8 1.8 646544 2.2 2.2 646646 2.1 2.1 646520 1.6 1.6 646569 2.1 2.1 646654 1.8 1.8 646668 2.4 2.4 646580 1.9 1.9 646581 1.9 1.9 646627 1.9 1.9 646565 2.2 2.2 646551 2.1 2.1 646511 2.2 2.2 646549 2.0 2.0 646652 2.1 2.1 646586 2.1 2.1 646613 1.9 1.9 Day 38 2.1 1.7 2.3 1.7 1.9 2.1 2.2 2.5 2.0 1.9 1.7 1.9 2.1 2.1 1.8 1.8 2.2 1.8 2.2 2.1 1.9 1.8 2.1 1.9 2.1 2.0 1.6 1.9 1.8 2.2 2.1 1.6 2.1 1.8 2.4 1.9 1.9 1.9 2.2 2.1 2.2 2.0 2.1 2.1 1.9 Day 39 2.1 1.7 2.3 1.7 1.9 2.1 2.2 2.5 2.0 1.9 1.7 1.9 2.1 2.1 1.8 1.8 2.2 1.8 2.2 2.1 1.9 1.8 2.1 1.9 2.1 2.0 1.6 1.9 1.8 2.2 2.1 1.6 2.1 1.8 2.4 1.9 1.9 1.9 2.2 2.1 2.2 2.0 2.1 2.1 1.9 Day 40 2.1 1.7 2.3 1.7 1.9 2.1 2.2 2.5 2.0 1.9 1.7 1.9 2.1 2.1 1.8 1.8 2.2 1.8 2.2 2.1 1.9 1.8 2.1 1.9 2.1 2.0 1.6 1.9 1.8 2.2 2.1 1.6 2.1 1.8 2.4 1.9 1.9 1.9 2.2 2.1 2.2 2.0 2.1 2.1 1.9 Day 41 2.1 1.7 2.3 1.7 1.9 2.1 2.2 2.5 2.0 1.9 1.7 1.9 2.1 2.1 1.8 1.8 2.2 1.8 2.2 2.1 1.9 1.8 2.1 1.9 2.1 2.0 1.6 1.9 1.8 2.2 2.1 1.6 2.1 1.8 2.4 1.9 1.9 1.9 2.2 2.1 2.2 2.0 2.1 2.1 1.9 Day 42 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 Day 43 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 Day 44 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 Day 45 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 Day 46 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 Day 47 2.1 1.7 2.2 1.8 2.0 2.2 2.2 2.5 2.0 2.0 1.8 2.0 2.1 2.2 1.9 2.0 2.2 1.9 2.4 2.2 2.0 2.0 2.2 2.0 2.2 2.1 1.8 1.9 1.9 2.2 2.1 1.7 2.1 2.0 2.5 1.9 2.0 2.0 2.2 2.2 2.3 2.2 2.3 2.1 2.0 -486- ))) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Company Sanitized. Does not contain TSCA C8I INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Female, II - 0 mg/kg/day 646592 2.1 2.2 646560 1.7 1.8 646676 2.2 2.5 646665 1.8 1.8 646612 2.0 2.1 646538 2.2 2.3 646659 2.2 2.3 646649 2.5 2.6 646617 2.0 2.2 646537 2.0 2.0 646642 1.8 1.8 646530 2.0 2.1 646588 2.1 2.2 646597 2.2 2.3 646507 1.9 1.9 646653 2.0 2.0 646575 2.2 2.4 646585 1.9 2.0 646622 2.4 2.5 646550 2.2 2.3 646526 2.0 2.1 646503 2.0 2.0 646644 2.2 2.3 646604 2.0 2.1 646651 2.2 2.2 646552 2.1 2.1 646606 1.8 1.8 646557 1.9 2.0 646591 1.9 1.9 646544 2.2 2.3 646646 2.1 2.2 646520 1.7 1.8 646569 2.1 2.2 646654 2.0 2.0 646668 2.5 2.6 646580 1.9 2.0 646581 2.0 2.0 646627 2.0 2.0 646565 2.2 2.3 646551 2.2 2.3 646511 2.3 2.4 646549 2.2 2.3 646652 2.3 2.3 646586 2.1 2.2 646613 2.0 2.1 Day 50 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 51 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 52 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 53 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 54 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 55 2.2 1.8 2.5 1.8 2.1 2.3 2.3 2.6 2.2 2.0 1.8 2.1 2.2 2.3 1.9 2.0 2.4 2.0 2.5 2.3 2.1 2.0 2.3 2.1 2.2 2.1 1.8 2.0 1.9 2.3 2.2 1.8 2.2 2.0 2.6 2.0 2.0 2.0 2.3 2.3 2.4 2.3 2.3 2.2 2.1 Day 56 2.3 1.9 2.4 1.9 2.0 2.4 2.4 2.7 2.2 2.1 1.8 2.1 2.2 2.3 2.0 2.1 2.4 2.0 2.5 2.4 2.1 2.1 2.3 2.1 2.3 2.2 1.8 2.0 2.0 2.3 2.3 1.8 2.2 2.0 2.6 2.1 2.1 2.0 2.5 2.4 2.3 2.4 2.4 2.2 2.1 Day 57 2.3 1.9 2.4 1.9 2.0 2.4 2.4 2.7 2.2 2.1 1.8 2.1 2.2 2.3 2.0 2.1 2.4 2.0 2.5 2.4 2.1 2.1 2.3 2.1 2.3 2.2 1.8 2.0 2.0 2.3 2.3 1.8 2.2 2.0 2.6 2.1 2.1 2.0 2.5 2.4 2.3 2.4 2.4 2.2 2.1 Day 58 2.3 1.9 2.4 1.9 2.0 2.4 2.4 2.7 2.2 2.1 1.8 2.1 2.2 2.3 2.0 2.1 2.4 2.0 2.5 2.4 2.1 2.1 2.3 2.1 2.3 2.2 1.8 2.0 2.0 2.3 2.3 1.8 2.2 2.0 2.6 2.1 2.1 2.0 2.5 2.4 2.3 2.4 2.4 2.2 2.1 Day 59 2.3 1.9 2.4 1.9 2.0 2.4 2.4 2.7 2.2 2.1 1.8 2.1 2.2 2.3 2.0 2.1 2.4 2.0 2.5 2.4 2.1 2.1 2.3 2.1 2.3 2.2 1.8 2.0 2.0 2.3 2.3 1.8 2.2 2.0 2.6 2.1 2.1 2.0 2.5 2.4 2.3 2.4 2.4 2.2 2.1 -487- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA C8I INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Female, II - 0 mg/kg/day 646592 2.3 2.3 646560 1.9 1.9 646676 2.4 2.4 646665 1.9 1.9 646612 2.0 2.0 646538 2.4 2.4 646659 2.4 2.4 646649 2.7 2.7 646617 2.2 2.2 646537 2.1 2.1 646642 1.8 1.8 646530 2.1 2.1 646588 2.2 2.2 646597 2.3 2.3 646507 2.0 2.0 646653 2.1 2.1 646575 2.4 2.4 646585 2.0 2.0 646622 2.5 2.5 646550 2.4 2.4 646526 2.1 2.1 646503 2.1 2.1 646644 2.3 2.3 646604 2.1 2.1 646651 2.3 2.3 64655.2 2.2 2.2 646606 1.8 1.8 646557 2.0 2.0 646591 2.0 2.0 646544 2.3 2.3 646646 2.3 2.3 646520 1.8 1.8 646569 2.2 2.2 646654 2.0 2.0 646668 2.6 2.6 646580 2.1 2.1 646581 2.1 2.1 646627 2.0 2.0 646565 2.5 2.5 646551 2.4 2.4 646511 2.3 2.3 646549 2.4 2.4 646652 2.4 2.4 646586 2.2 2.2 646613 2.1 2.1 Day 62 2.3 1.9 2.4 1.9 2.0 2.4 2.4 2.7 2.2 2.1 1.8 2.1 2.2 2.3 2.0 2.1 2.4 2.0 2.5 2.4 2.1 2.1 2.3 2.1 2.3 2.2 1.8 2.0 2.0 2.3 2.3 1.8 2.2 2.0 2.6 2.1 2.1 2.0 2.5 2.4 2.3 2.4 2.4 2.2 2.1 Day 63 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 64 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 65 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 66 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 67 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 68 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 69 2.3 1.9 2.5 1.9 2.1 2.4 2.4 2.7 2.2 2.1 1.9 2.1 2.2 2.5 2.0 2.1 2.4 2.0 2.6 2.5 2.2 2.1 2.3 2.2 2.3 2.2 1.8 2.1 2.1 2.4 2.4 1.9 2.2 2.2 2.6 2.1 2.1 2.1 2.6 2.4 2.3 2.4 2.4 2.1 2.2 Day 70 2.4 1.9 2.5 2.0 2.2 2.5 2.5 2.7 2.3 2.2 2.0 2.2 2.3 2.5 2.1 2.1 2.5 2.1 2.7 2.6 2.2 2.1 2.3 2.2 2.3 2.3 1.9 2.2 2.1 2.4 2.4 1.8 2.2 2.2 2.6 2.1 2.2 2.2 2.6 2.4 2.4 2.6 2.5 2.2 2.3 Day 71 2. 4 1. 9 2. 5 2. 0 2. 2 2. 5 2. 5 2. 7 2. 3 2. 2 2. 0 2. 2 2. 3 2. 5 2. 1 2. 1 2. 2 2. 2 2. 6 2. 4 2. 4 2. 6 2. 5 2. 2 2. 3 -488- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Female, II - 0 mg/kg/day 646592 2.4 2.4 646560 1.9 1.9 646676 2.5 2.5 646665 2.0 2.0 646612 2.2 2.2 646538 2.5 2.5 646659 2.5 2.5 646649 2.7 2.7 646617 2.3 2.3 646537 2.2 2.2 646642 2.0 2.0 646530 2.2 2.2 646588 2.3 2.3 646597 2.5 2.5 646507 2.1 2.1 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 2.1 2.1 646581 2.2 2.2 646627 2.2 2.2 646565 2.6 2.6 646551 2.4 2.4 646511 2.4 2.4 646549 2.6 2.6 646652 2.5 2.5 646586 2.2 2.2 646613 2.3 2.3 Day 74 2.4 1.9 2.5 2.0 2.2 2.5 2.5 2.7 2.3 2.2 2.0 2.2 2.3 2.5 2.1 2.1 2.2 2.2 2.6 2.4 2.4 2.6 2.5 2.2 2.3 Day 75 2.4 1.9 2.5 2.0 2.2 2.5 2.5 2.7 2.3 2.2 2.0 2.2 2.3 2.5 2.1 2.1 2.2 2.2 2.6 2.4 2.4 2.6 2.5 2.2 2.3 Day 76 2.4 1.9 2.5 2.0 2.2 2.5 2.5 2.7 2.3 2.2 2.0 2.2 2.3 2.5 2.1 2.1 2.2 2.2 2.6 2.4 2.4 2.6 2.5 2.2 2.3 Day 77 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 78 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 79 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 80 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 81 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 82 2.4 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.4 2.2 2.0 2.1 2.3 2.5 2.1 2.2 2.2 2.2 2.6 2.5 2.5 2.7 2.5 2.2 2.2 Day 83 2. 4 1. 9 2. 6 2. 0 2. 2 2. 6 2. 5 2. 8 2. 4 2. 2 2. 0 2. 1 2. 3 2. 5 2. 1 22 22 22 26 25 25 27 25 22 22 -489- )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations__________________________________________________________________ DuPont-5990 Company Sanitized. Does not contain TSCA C8I INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Female, II - 0 mg/kg/day 646592 2.5 2.5 646560 1.9 1.9 646676 2.6 2.6 646665 2.0 2.0 646612 2.2 2.2 646538 2.6 2.6 646659 2.5 2.5 646649 2.8 2.8 646617 2.3 2.3 646537 2.2 2.2 646642 2.1 2.1 646530 2.3 2.3 646588 2.4 2.4 646597 2.6 2.6 646507 2.2 2.2 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 2.1 2.1 646581 2.3 2.3 646627 2.2 2.2 646565 2.7 2.7 646551 2.5 2.5 646511 2.5 2.5 646549 2.7 2.7 646652 2.5 2.5 646586 2.2 2.2 646613 2.2 2.2 Day 86 2.5 1-9 2.6 2.0 2.2 2.6 2.5 2.8 2.3 2.2 2.1 2.3 2.4 2.6 2.2 2.1 2.3 2.2 2.7 2.5 2.5 2.7 2.5 2.2 2.2 Day 87 2.5 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.3 2.2 2.1 2.3 2.4 2.6 2.2 2.1 2.3 2.2 2.7 2.5 2.5 2.7 2.5 2.2 2.2 Day 88 2.5 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.3 2.2 2.1 2.3 2.4 2.6 2.2 2.1 2.3 2.2 2.7 2.5 2.5 2.7 2.5 2.2 2.2 Day 89 2.5 1.9 2.6 2.0 2.2 2.6 2.5 2.8 2.3 2.2 2.1 2.3 2.4 2.6 2.2 2.1 2.3 2.2 2.7 2.5 2.5 2.7 2.5 2.2 2.2 Day 90 Day 91 2.5 2.6 1.9 1.9 2.6 2.6 2.0 2.1 2.2 2.2 2.6 2.5 2.5 2.5 2.8 2.8 2.3 2.4 2.2 2.3 AK TEST DAY 89 2.3 2.4 2.6 2.2 2.1 2.3 2.2 2.7 2.5 2.5 2.7 2.5 2.2 2.2 Day 92 2.6 1.9 2.6 2.1 2.2 2.5 2.5 2.8 2.4 2.3 Day 93 2.6 1.9 2.6 2.1 2.2 2.5 2.5 2.8 2.4 2.3 Day 94 2.6 1.9 2.6 2.1 2.2 2.5 2.5 2.8 2.4 2.3 Day 95 2.6 1.9 2.6 2.1 2.2 2.5 2.5 2.8 2.4 2.3 -490- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Female, IV - 25 mg/kg/day 646522 1.2 1.2 646660 1.1 1.1 646502 1.2 1.2 646595 1.2 1.2 646567 1.4 1.4 646673 1.3 1.3 646635 1.3 1.3 646664 1.3 1.3 646621 1.4 1.4 646576 1.4 1.4 646625 1.3 1.3 646568 1.4 1.4 646626 1.2 1.2 646531 1.4 1.4 646636 1.3 1.3 646638 1.4 1.4 646559 1.3 1.3 646598 1.5 1.5 646561 1.3 1.3 646573 1.4 1.4 646504 1.4 1.4 646587 1.2 1.2 646631 1.6 1.6 646529 1.3 1.3 646603 1.3 1.3 646554 1.4 1.4 646579 1.2 1.2 646564 1.3 1.3 646672 1.4 1.4 646584 1.4 1.4 646543 1.2 1.2 646596 1.3 1.3 646558 1.3 1.3 646670 1.4 1.4 646553 1.4 1.4 Day 2 1.2 1.1 1.2 1.2 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.2 1.4 1.3 1.4 1.3 1.5 1.3 1.4 1.4 1.2 1.6 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.2 1.3 1.3 1.4 1.4 Day 3 1.2 1.1 1.2 1.2 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.2 1.4 1.3 1.4 1.3 1.5 1.3 1.4 1.4 1.2 1.6 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.2 1.3 1.3 1.4 1.4 Day 4 1.2 1.1 1.2 1.2 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.2 1.4 1.3 1.4 1.3 1.5 1.3 1.4 1.4 1.2 1.6 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.2 1.3 1.3 1.4 1.4 Day 5 Day 6 1.2 1.1 1.2 1.2 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.2 1.4 1.3 1.4 1.3 1.5 1.3 1.4 1.4 1.2 1.6 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.2 1.3 1.3 1.4 1.4 1.2 1.1 1.2 1.2 1.4 1.3 1.3 1.3 1.4 1.4 1.3 1.4 1.2 1.4 1.3 1.4 1.3 1.5 1.3 1.4 1.4 1.2 1.6 1.3 1.3 1.4 1.2 1.3 1.4 1.4 1.2 1.3 1.3 1.4 1.4 Day 7 1.4 1.3 1.3 1.3 1.5 1.4 1.4 1.5 1.6 1.6 1.4 1.6 1.3 1.5 1.4 1.5 1.5 1.7 1.5 1.5 1.5 1.3 1.8 1.4 1.4 1.6 1.4 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.5 Day 8 1.4 1.3 1.3 1.3 1.5 1.4 1.4 1.5 1.6 1.6 1.4 1.6 1.3 1.5 1.4 1.5 1.5 1.7 1.5 1.5 1.5 1.3 1.8 1.4 1.4 1.6 1.4 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.5 Day 9 1.4 1.3 1.3 1.3 1.5 1.4 1.4 1.5 1.6 1.6 1.4 1.6 1.3 1.5 1.4 1.5 1.5 1.7 1.5 1.5 1.5 1.3 1.8 1.4 1.4 1.6 1.4 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.5 Day 10 1.4 1.3 1.3 1.3 1.5 1.4 1.4 1.5 1.6 1.6 1.4 1.6 1.3 1.5 1.4 1.5 1.5 1.7 1.5 1.5 1.5 1.3 1.8 1.4 1.4 1.6 1.4 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.5 Day 11 1.4 1.3 1.3 1.3 1.5 1.4 1.4 1.5 1.6 1.6 1.4 1.6 1.3 1.5 1.4 1.5 1.5 1.7 1.5 1.5 1.5 1.3 1.8 1.4 1.4 1.6 1.4 1.5 1.6 1.5 1.3 1.5 1.5 1.6 1.5 Company Sanitized. Does not contain TSCA CBI -491- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Female, IV - 25 mg/kg/day 646522 1.4 1.4 646660 1.3 1.3 646502 1.3 1.3 646595 1.3 1.3 646567 1.5 1.5 646673 1.4 1.4 646635 1.4 1.4 646664 1.5 1.5 646621 1.6 1.6 646576 1.6 1.6 646625 1.4 1.4 646568 1.6 1.6 646626 1.3 1.3 646531 1.5 1.5 646636 1.4 1.4 646638 1.5 1.5 646559 1.5 1.5 646598 1.7 1.7 646561 1.5 1.5 646573 1.5 1.5 646504 1.5 1.5 646587 1.3 1.3 646631 1.8 1.8 646529 1.4 1.4 646603 1.4 1.4 646554 1.6 1.6 646579 1.4 1.4 646564 1.5 1.5 646672 1.6 1.6 646584 1.5 1.5 646543 1.3 1.3 646596 1.5 1.5 646558 1.5 1.5 646670 1.6 1.6 646553 1.5 1.5 Day 14 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1-5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 15 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 16 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 17 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 18 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 19 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 20 1.6 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.8 1.7 1.5 1.7 1.4 1.6 1.4 1.7 1.6 1.8 1.6 1.7 1.6 1.5 2.0 1.5 1.5 1.8 1.6 1.6 1.7 1.7 1.5 1.6 1.7 1.8 1.6 Day 21 1.7 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.9 2.0 1.6 1.9 1.5 1.8 1.5 1.9 1.8 2.0 1.9 1.8 1.7 1.6 2.2 1.7 1.8 1.9 1.7 1.8 1.9 1.8 1.6 1.8 1.8 2.0 1.7 Day 22 1.7 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.9 2.0 1.6 1.9 1.5 1.8 1.5 1.9 1.8 2.0 1.9 1.8 1.7 1.6 2.2 1.7 1.8 1.9 1.7 1.8 1.9 1.8 1.6 1.8 1.8 2.0 1.7 Day 23 1.7 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.9 2.0 1.6 1.9 1.5 1.8 1.5 1.9 1.8 2.0 1.9 1.8 1.7 1.6 2.2 1.7 1.8 1.9 1.7 1.8 1.9 1.8 1.6 1.8 1.8 2.0 1.7 Company Sanitized. Does not contain TSCA CBI -492- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Female, IV - 25 mg/kg/day 646522 1.7 1.7 646660 1.5 1.5 646502 1.5 1.5 646595 1.6 1.6 646567 1.8 1.8 646673 1.7 1.7 646635 1.7 1.7 646664 1.7 1.7 646621 1.9 1.9 646576 2.0 2.0 646625 1.6 1.6 646568 1.9 1.9 646626 1.5 1.5 646531 1.8 1.8 646636 1.5 1.5 646638 1.9 1.9 646559 1.8 1.8 646598 2.0 2.0 646561 1.9 1.9 646573 1.8 1.8 646504 1.7 1.7 646587 1.6 1.6 646631 2.2 2.2 646529 1.7 1.7 646603 1.8 1.8 646554 1.9 1.9 646579 1.7 1.7 646564 1.8 1.8 646672 1.9 1.9 646584 1.8 1.8 646543 1.6 1.6 646596 1.8 1.8 646558 1.8 1.8 646670 2.0 2.0 646553 1.7 1.7 Day 26 1.7 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.9 2.0 1.6 1.9 1.5 1.8 1.5 1.9 1.8 2.0 1.9 1.8 1.7 1.6 2.2 1.7 1.8 1.9 1.7 1.8 1.9 1.8 1.6 1.8 1.8 2.0 1.7 Day 27 1.7 1.5 1.5 1.6 1.8 1.7 1.7 1.7 1.9 2.0 1.6 1.9 1.5 1.8 1.5 1.9 1.8 2.0 1.9 1.8 1.7 1.6 2.2 1.7 1.8 1.9 1.7 1.8 1.9 1.8 1.6 1.8 1.8 2.0 1.7 Day 28 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 29 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 30 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 31 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 32 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 33 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 34 1.8 1.7 1.5 1.7 1.9 1.7 1.9 1.9 2.0 2.1 1.8 2.1 1.5 1.9 1.7 2.0 2.0 2.1 2.0 1.9 1.8 1.8 2.3 1.9 1.9 2.1 1.9 1.9 2.0 1.9 1.7 1.9 2.0 2.2 2.0 Day 35 1. 9 1. 7 1. 6 1. 9 2. 0 1. 8 1. 9 2. 0 2. 1 2. 2 1. 9 2. 2 1. 6 2. 0 1. 8 2. 1 2. 1 2. 2 2. 1 2. 0 1. 9 1. 9 2. 4 2. 0 2. 0 2. 2 1. 9 1. 9 2. 2 2. 0 1. 9 2. 0 2. 0 2. 3 2. 0 Company Sanitized. Does not contain TSCA CBI -493- ))) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Female, IV - 25 mg/kg/day 646522 1.9 1.9 646660 1.7 1.7 646502 1.6 1.6 646595 1.9 1.9 646567 2.0 2.0 646673 1.8 1.8 646635 1.9 1.9 646664 2.0 2.0 646621 2.1 2.1 646576 2.2 2.2 646625 1.9 1.9 646568 2.2 2.2 646626 1.6 1.6 646531 2.0 2.0 646636 1.8 1.8 646638 2.1 2.1 646559 2.1 2.1 646598 2.2 2.2 646561 2.1 2.1 646573 2.0 2.0 646504 1.9 1.9 646587 1.9 1.9 646631 2.4 2.4 646529 2.0 2.0 646603 2.0 2.0 646554 2.2 2.2 646579 1.9 1.9 646564 1.9 1.9 646672 2.2 2.2 646584 2.0 2.0 646543 1.9 1.9 646596 2.0 2.0 646558 2.0 2.0 646670 2.3 2.3 646553 2.0 2.0 Day 38 1.9 1.7 1.6 1.9 2.0 1.8 1.9 2.0 2.1 2.2 1.9 2.2 1.6 2.0 1.8 2.1 2.1 2.2 2.1 2.0 1.9 1.9 2.4 2.0 2.0 2.2 1.9 1.9 2.2 2.0 1.9 2.0 2.0 2.3 2.0 Day 39 1.9 1.7 1.6 1.9 2.0 1.8 1.9 2.0 2.1 2.2 1.9 2.2 1.6 2.0 1.8 2.1 2.1 2.2 2.1 2.0 1.9 1.9 2.4 2.0 2.0 2.2 1.9 1.9 2.2 2.0 1.9 2.0 2.0 2.3 2.0 Day 40 1.9 1.7 1.6 1.9 2.0 1.8 1.9 2.0 2.1 2.2 1.9 2.2 1.6 2.0 1.8 2.1 2.1 2.2 2.1 2.0 1.9 1.9 2.4 2.0 2.0 2.2 1.9 1.9 2.2 2.0 1.9 2.0 2.0 2.3 2.0 Day 41 1.9 1.7 1.6 1.9 2.0 1.8 1.9 2.0 2.1 2.2 1.9 2.2 1.6 2.0 1.8 2.1 2.1 2.2 2.1 2.0 1.9 1.9 2.4 2.0 2.0 2.2 1.9 1.9 2.2 2.0 1.9 2.0 2.0 2.3 2.0 Day 42 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Day 43 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Day 44 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Day 45 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Day 46 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Day 47 1.9 1.7 1.7 1.8 2.0 1.9 2.0 2.0 2.3 2.2 2.0 2.3 1.6 2.0 1.8 2.2 2.2 2.3 2.2 2.1 2.0 2.0 2.5 2.1 2.0 2.2 2.0 2.0 2.2 2.1 1.9 2.0 2.2 2.3 2.0 Company Sanitized. Does not contain TSCA CBI -494- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations > ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Female, IV - 25 mg/kg/day 646522 1.9 2.0 646660 1.7 1.8 646502 1.7 1.8 646595 1.8 2.0 646567 2.0 2.2 646673 1.9 1.9 646635 2.0 2.1 646664 2.0 2.1 646621 2.3 2.3 646576 2.2 2.3 646625 2.0 2.1 646568 2.3 2.4 646626 1.6 1.7 646531 2.0 2.1 646636 1.8 1.9 646638 2.2 2.4 646559 2.2 2.3 646598 2.3 2.5 646561 2.2 2.1 646573 2.1 2.3 646504 2.0 2.1 646587 2.0 2.0 646631 2.5 2.6 646529 2.1 2.2 646603 2.0 2.1 646554 2.2 2.3 646579 2.0 2.0 646564 2.0 2.0 646672 2.2 2.3 646584 2.1 2.1 646543 1.9 2.0 646596 2.0 2.0 646558 2.2 2.2 646670 2.3 2.4 646553 2.0 2.1 Day 50 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 51 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 52 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 53 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 54 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 55 2.0 1.8 1.8 2.0 2.2 1.9 2.1 2.1 2.3 2.3 2.1 2.4 1.7 2.1 1.9 2.4 2.3 2.5 2.1 2.3 2.1 2.0 2.6 2.2 2.1 2.3 2.0 2.0 2.3 2.1 2.0 2.0 2.2 2.4 2.1 Day 56 2.1 1.9 1.9 2.0 2.2 1.9 2.2 2.2 2.4 2.4 2.1 2.5 1.7 2.1 2.0 2.3 2.3 2.6 2.3 2.3 2.2 2.0 2.6 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.0 2.2 2.5 2.2 Day 57 2.1 1.9 1.9 2.0 2.2 1.9 2.2 2.2 2.4 2.4 2.1 2.5 1.7 2.1 2.0 2.3 2.3 2.6 2.3 2.3 2.2 2.0 2.6 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.0 2.2 2.5 2.2 Day 58 2.1 1.9 1.9 2.0 2.2 1.9 2.2 2.2 2.4 2.4 2.1 2.5 1.7 2.1 2.0 2.3 2.3 2.6 2.3 2.3 2.2 2.0 2.6 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.0 2.2 2.5 2.2 Day 59 2.1 1.9 1.9 2.0 2.2 1.9 2.2 2.2 2.4 2.4 2.1 2.5 1.7 2.1 2.0 2.3 2.3 2.6 2.3 2.3 2.2 2.0 2.6 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.0 2.2 2.5 2.2 Company Sanitized. Does not contain TSCA CBI -495- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Female, IV - 25 mg/kg/day 646522 2.1 2.1 646660 1.9 1.9 646502 1.9 1.9 646595 2.0 2.0 646567 2.2 2.2 646673 1.9 1.9 646635 2.2 2.2 646664 2.2 2.2 646621 2.4 2.4 646576 2.4 2.4 646625 2.1 2.1 646568 2.5 2.5 646626 1.7 1.7 646531 2.1 2.1 646636 2.0 2.0 646638 2.3 2.3 646559 2.3 2.3 646598 2.6 2.6 646561 2.3 2.3 646573 2.3 2.3 646504 2.2 2.2 646587 2.0 2.0 646631 2.6 2.6 646529 2.2 2.2 646603 2.1 2.1 646554 2.4 2.4 646579 2.1 2.1 646564 2.1 2.1 646672 2.3 2.3 646584 2.1 2.1 646543 2.1 2.1 646596 2.0 2.0 646558 2.2 2.2 646670 2.5 2.5 646553 2.2 2.2 Day 62 2.1 1.9 1.9 2.0 2.2 1.9 2.2 2.2 2.4 2.4 2.1 2.5 1.7 2.1 2.0 2.3 2.3 2.6 2.3 2.3 2.2 2.0 2.6 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.0 2.2 2.5 2.2 Day 63 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 64 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 65 Day 66 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 67 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 68 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 69 2.1 1.9 1.8 2.0 2.3 1.9 2.2 2.1 2.5 2.5 2.2 2.5 1.7 2.2 2.0 2.3 2.3 2.6 2.3 2.4 2.2 1.9 2.7 2.2 2.1 2.4 2.1 2.1 2.3 2.1 2.1 2.1 2.3 2.5 2.2 Day 70. 2.2 1.9 1.8 2.0 2.4 1.9 2.3 2.3 2.6 2.5 2.2 2.7 1.8 2.1 2.0 2.3 2.4 2.6 2.3 2.4 2.2 2.0 2.7 2.2 2.2 2.3 2.1 2.2 2.4 2.2 2.2 2.1 2.3 2.5 2.3 Day 71 2. 2 1. 9 1. 8 2. 0 2. 4 1. 9 2. 3 2. 3 2. e 2. 5 2. 2 2. 7 1. 8 2. 1 2. 0 Company Sanitized. Does not contain TSCA CBI -496- )) ) H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Female, IV - 25 mg/kg/day 646522 2.2 2.2 646660 1.9 1.9 646502 1.8 1.8 646595 2.0 2.0 646567 2.4 2.4 646673 1.9 1.9 646635 2.3 2.3 646664 2.3 2.3 646621 2.6 2.6 646576 2.5 2.5 646625 2.2 2.2 646568 2.7 2.7 646626 1.8 1.8 646531 2.1 2.1 646636 2.0 2.0 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 Day 74 2.2 1.9 1.8 2.0 2.4 1.9 2.3 2.3 2.6 2.5 2.2 2.7 1.8 2.1 2.0 Day 75 2.2 1.9 1.8 2.0 2.4 1.9 2.3 2.3 2.6 2.5 2.2 2.7 1.8 2.1 2.0 Day 76 2.2 1.9 1.8 2.0 2.4 1.9 2.3 2.3 2.6 2.5 2.2 2.7 1.8 2.1 2.0 Day 77 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 78 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 79 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 80 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 81 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 82 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Day 83 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.5 2.7 2.2 2.7 1.7 2.2 2.1 Company Sanitized. Does not contain TSCA CBI -497- )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Genertion Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Female, IV - 25 mg/kg/day 646522 2.2 2.2 646660 2.0 2.0 646502 1.9 1.9 646595 2.1 2.1 646567 2.5 2.5 646673 2.0 2.0 646635 2.3 2.3 646664 2.3 2.3 646621 2.6 2.6 646576 2.7 2.7 646625 2.3 2.3 646568 2.8 2.8 646626 1.8 1.8 646531 2.2 2.2 646636 2.2 2.2 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 Day 86 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.6 2.7 2.3 2.8 1.8 2.2 2.2 Day 87 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.6 2.7 2.3 2.8 1.8 2.2 2.2 Day 88 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.6 2.7 2.3 2.8 1.8 2.2 2.2 Day 89 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.6 2.7 2.3 2.8 1.8 2.2 2.2 Day 90 2.2 2.0 1.9 2.1 2.5 2.0 2.3 2.3 2.6 2.7 2.3 2.8 1.8 2.2 2.2 Day 91 2.2 2.0 2.0 2.1 2.5 2.0 2.3 2.4 2.7 2.7 Day 92 2.2 2.0 2.0 2.1 2.5 2.0 2.3 2.4 2.7 2.7 Day 93 2.2 2.0 2.0 2.1 2.5 2.0 2.3 2.4 2.7 2.7 Day 94 2.2 2.0 2.0 2.1 2.5 2.0 2.3 2.4 2.7 2.7 Day 95 2.2 2.0 2.0 2.1 2.5 2.0 2.3 2.4 2.7 2.7 Company Sanitized. Does not contain TSCA CBI -498- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Female, VI - 100 mg/kg/day 646608 1.2 1.2 646556 1.3 1.3 646629 1.3 1.3 646510 1.4 1.4 646578 1.4 1.4 646505 1.3 1.3 646534 1.3 1.3 646624 1.3 1.3 646501 1.3 1.3 646633 1.4 1.4 646656 1.2 1.2 646630 1.5 1.5 646634 1.2 1.2 646533 1.3 1.3 646632 1.4 1.4 646547 1.2 1.2 646666 1.5 1.5 646607 1.4 1.4 646524 1.4 1.4 646600 1.4 1.4 646648 1.3 1.3 646594 1.3 1.3 646546 1.4 1.4 646661 1.4 1.4 646671 1.3 1.3 646521 1.3 1.3 646590 1.3 1.3 646645 1.3 1.3 646555 1.4 1.4 646605 1.3 1.3 646589 1.2 1.2 646615 1.2 1.2 646527 1.3 1.3 646647 1.4 1.4 646675 1.2 1.2 Day 2 1.2 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.2 1.5 1.2 1.3 1.4 1.2 1.5 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.2 1.2 1.3 1.4 1.2 Day 3 1.2 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.2 1.5 1.2 1.3 1.4 1.2 1.5 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.2 1.2 1.3 1.4 1.2 Day 4 1.2 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.2 1.5 1.2 1.3 1.4 1.2 1.5 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.2 1.2 1.3 1.4 1.2 Day 5 1.2 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.2 1.5 1.2 1.3 1.4 1.2 1.5 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.2 1.2 1.3 1.4 1.2 Day 6 1.2 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.2 1.5 1.2 1.3 1.4 1.2 1.5 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.2 1.2 1.3 1.4 1.2 Day 7 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.5 1.4 1.7 1.4 1.4 1.5 1.4 1.7 1.5 1.4 1.5 1.3 1.5 1.4 1.5 1.4 1.4 1.4 1.4 1.6 1.4 1.3 1.3 1.4 1.5 1.4 Day 8 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.5 1.4 1.7 1.4 1.4 1.5 1.4 1.7 1.5 1.4 1.5 1.3 1.5 1.4 1.5 1.4 1.4 1.4 1.4 1.6 1.4 1.3 1.3 1.4 1.5 1.4 Day 9 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.5 1.4 1.7 1.4 1.4 1.5 1.4 1.7 1.5 1.4 1.5 1.3 1.5 1.4 1.5 1.4 1.4 1.4 1.4 1.6 1.4 1.3 1.3 1.4 1.5 1.4 Day 10 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.5 1.4 1.7 1.4 1.4 1.5 1.4 1.7 1.5 1.4 1.5 1.3 1.5 1.4 1.5 1.4 1.4 1.4 1.4 1.6 1.4 1.3 1.3 1.4 1.5 1.4 Day 11 1. 4 1. 5 1. 5 1. 5 1. 5 1. 5 1. 5 1. 4 1. 4 1. 5 1. 4 1. 7 1. 4 1. 4 1. 5 1. 4 1. 7 1. 5 1. 4 1. 5 1. 3 1. 5 1. 4 1. 5 1. 4 1. 4 1. 4 1. 4 1. 6 1. 4 1. 3 1. 3 1. 4 1. 5 1. 4 Company Sanitized. Does not contain TSCA CBI -499- )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Female, VI - 100 mg/kg/day 646608 1.4 1.4 646556 1.5 1.5 646629 1.5 1.5 646510 1.5 1.5 646578 1.5 1.5 646505 1.5 1.5 646534 1.5 1.5 646624 1.4 1.4 646501 1.4 1.4 646633 1.5 1.5 646656 1.4 1.4 646630 1.7 1.7 646634 1.4 1.4 646533 1.4 1.4 646632 1.5 1.5 646547 1.4 1.4 646666 1.7 1.7 646607 1.5 1.5 646524 1.4 1.4 646600 1.5 1.5 646648 1.3 1.3 646594 1.5 1.5 646546 1.4 1.4 646661 1.5 1.5 646671 1.4 1.4 646521 1.4 1.4 646590 1.4 1.4 646645 1.4 1.4 646555 1.6 1.6 646605 1.4 1.4 646589 1.3 1.3 646615 1.3 1.3 646527 1.4 1.4 646647 1.5 1.5 646675 1.4 1.4 Day 14 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 15 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 16 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 17 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 18 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 19 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 20 1.6 1.6 1.6 1.7 1.7 1.6 1.7 1.6 1.6 1.7 1.6 1.8 1.4 1.5 1.7 1.5 1.9 1.6 1.6 1.7 1.5 1.6 1.6 1.7 1.6 1.6 1.6 1.5 1.8 1.6 1.4 1.5 1.6 1.7 1.6 Day 21 1.7 1.8 1.7 1.8 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.0 1.6 1.6 1.9 1.6 2.0 1.8 1.7 1.9 1.6 1.7 1.7 1.9 1.8 1.8 1.7 1.6 1.9 1.8 1.4 1.7 1.8 1.8 1.8 Day 22 Day 23 1.7 1.8 1.7 1.8 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.0 1.6 1.6 1.9 1.6 2.0 1.8 1.7 1.9 1.6 1.7 1.7 1.9 1.8 1.8 1.7 1.6 1.9 1.8 1.4 1.7 1.8 c 1.8 1.8 1.7 1.8 1.7 1.8 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.0 1.6 1.6 1.9 1.6 2.0 1.8 1.7 1.9 1.6 1.7 1.7 1.9 1.8 1.8 1.7 1.6 1.9 1.8 1.4 1.7 1.8 1.8 1.8 Company Sanitized. Does not contain TSCA CBI -500- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations_____________________________________________________________ ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Female, VI - 100 mg/kg/day 646608 1.7 1.7 646556 1.8 1.8 646629 1.7 1.7 646510 1.8 1.8 646578 1.9 1.9 646505 1.8 1.8 646534 1.8 1.8 646624 1.8 1.8 646501 1.8 1.8 646633 1.8 1.8 646656 1.8 1.8 646630 2.0 2.0 646634 1.6 1.6 646533 1.6 1.6 646632 1.9 1.9 646547 1.6 1.6 646666 2.0 2.0 646607 1.8 1.8 646524 1.7 1.7 646600 1.9 1.9 646648 1.6 1.6 646594 1.7 1.7 646546 1.7 1.7 646661 1.9 1.9 646671 1.8 1.8 646521 1.8 1.8 646590 1.7 1.7 646645 1.6 1.6 646555 1.9 1.9 646605 1.8 1.8 646589 1.4 1.4 646615 1.7 1.7 646527 1.8 1.8 646647 1.8 1.8 646675 1.8 1.8 Day 26 1.7 1.8 1.7 1.8 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.0 1.6 1.6 1.9 1.6 2.0 1.8 1.7 1.9 1.6 1.7 1.7 1.9 1.8 1.8 1.7 1.6 1.9 1.8 1.4 1.7 1.8 1.8 1.8 Day 27 1.7 1.8 1.7 1.8 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.0 1.6 1.6 1.9 1.6 2.0 1.8 1.7 1.9 1.6 1.7 1.7 1.9 1.8 1.8 1.7 1.6 1.9 1.8 1.4 1.7 1.8 1.8 1.8 Day 28 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 29 Day 30 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 ' 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 31 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 32 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 33 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 34 1.8 1.9 1.9 2.1 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.2 1.7 1.8 1.9 1.7 2.2 1.9 1.8 1.9 1.6 1.8 1.8 1.9 2.0 1.9 1.9 1.8 2.1 1.9 1.6 1.8 2.0 1.9 1.9 Day 35 1.8 2.0 1.9 2.1 2.0 1.9 2.0 1.9 2.0 2.0 1.9 2.3 1.7 1.8 1.9 1.9 2.2 2.0 1.9 2.0 1.8 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 1.6 1.9 2.0 1.9 2.0 Company Sanitized. Does not contain TSCA CBI -501- )) ) H90--2D47ay68G: aSvuabgcehSrotunidcyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________ DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Female, VI - 100 mg/kg/day 646608 1.8 1.8 646556 2.0 2.0 646629 1.9 1.9 646510 2.1 2.1 646578 2.0 2.0 646505 1.9 1.9 646534 2.0 2.0 646624 1.9 1.9 646501 2.0 2.0 646633 2.0 2.0 646656 1.9 1.9 646630 2.3 2.3 646634 1.7 1.7 646533 1.8 1.8 646632 1.9 1.9 646547 1.9 1.9 646666 2.2 2.2 646607 2.0 2.0 646524 1.9 1.9 646600 2.0 2.0 646648 1.8 1.8 646594 1.9 1.9 646546 1.9 1.9 646661 2.0 2.0 646671 2.0 2.0 646521 2.0 2.0 646590 2.0 2.0 646645 1.9 1.9 646555 1.9 1.9 646605 2.0 2.0 646589 1.6 1.6 646615 1.9 1.9 646527 2.0 2.0 646647 1.9 1.9 646675 2.0 2.0 Day 38 1.8 2.0 1.9 2.1 2.0 1.9 2.0 1.9 2.0 2.0 . 1.9 2.3 1.7 1.8 1.9 1.9 2.2 2.0 1.9 2.0 1.8 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 1.6 1.9 2.0 1.9 2.0 Day 39 1.8 2.0 1.9 2.1 2.0 1.9 2.0 1.9 2.0 2.0 1.9 2.3 1.7 1.8 1.9 1.9 2.2 2.0 1.9 2.0 1.8 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 1.6 1.9 2.0 1.9 2.0 Day 40 1.8 2.0 1.9 2.1 2.0 1.9 2.0 1.9 2.0 2.0 1.9 2.3 1.7 1.8 1.9 1.9 2.2 2.0 1.9 2.0 1.8 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 1.6 1.9 2.0 1.9 2.0 Day 41 1.8 2.0 1.9 2.1 2.0 1.9 2.0 1.9 2.0 2.0 1.9 2.3 1.7 1.8 1.9 1.9 2.2 2.0 1.9 2.0 1.8 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 1.6 1.9 2.0 1.9 2.0 Day 42 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Day 43 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Day 44 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Day 45 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Day 46 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Day 47 1.9 2.1 1.9 2.2 2.1 2.1 2.1 2.0 2.0 2.1 2.1 2.5 1.7 1.9 2.1 1.9 2.3 1.9 2.0 2.1 1.8 2.0 1.9 2.2 2.1 2.1 2.1 1.9 2.1 2.1 1.7 2.0 2.1 2.0 2.0 Company Sanitized. Does not contain TSCA CBI -502- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Female, VI - 100 mg/kg/day 646608 1.9 2.0 646556 2.1 2.3 646629 1.9 2.0 646510 2.2 2.3 646578 2.1 2.2 646505 2.1 2.3 646534 2.1 2.2 646624 2.0 2.1 646501 2.0 2.1 646633 2.1 2.2 646656 2.1 2.1 646630 2.5 2.6 646634 1.7 1.9 646533 1.9 1.9 646632 2.1 2.1 646547 1.9 2.0 646666 2.3 2.5 646607 1.9 2.3 646524 2.0 2.0 646600 2.1 2.2 646648 1.8 1.9 646594 2.0 2.0 646546 1.9 1.9 646661 2.2 2.3 646671 2.1 2.2 646521 2.1 2.1 646590 2.1 2.2 646645 1.9 2.0 646555 2.1 2.2 646605 2.1 2.1 646589 1.7 1.7 646615 2.0 2.1 646527 2.1 2.1 646647 2.0 2.1 646675 2.0 2.2 Day 50 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 51 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 52 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 53 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 54 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 55 2.0 2.3 2.0 2.3 2.2 2.3 2.2 2.1 2.1 2.2 2.1 2.6 1.9 1.9 2.1 2.0 2.5 2.3 2.0 2.2 1.9 2.0 1.9 2.3 2.2 2.1 2.2 2.0 2.2 2.1 1.7 2.1 2.1 2.1 2.2 Day 56 1.9 2.4 2.1 2.4 2.1 2.4 2.2 2.1 2.2 2.3 2.2 2.7 1.9 2.0 2.2 2.1 2.5 2.3 2.1 2.2 2.0 2.1 2.0 2.3 2.2 2.1 2.2 2.0 2.3 2.1 1.7 2.1 2.2 2.1 2.2 Day 57 1.9 2.4 2.1 2.4 2.1 2.4 2.2 2.1 2.2 2.3 2.2 2.7 1.9 2.0 2.2 2.1 2.5 2.3 2.1 2.2 2.0 2.1 2.0 2.3 2.2 2.1 2.2 2.0 2.3 2.1 1.7 2.1 2.2 2.1 2.2 Day 58 1.9 2.4 2.1 2.4 2.1 2.4 2.2 2.1 2.2 2.3 2.2 2.7 1.9 2.0 2.2 2.1 2.5 2.3 2.1 2.2 2.0 2.1 2.0 2.3 2.2 2.1 2.2 2.0 2.3 2.1 1.7 2.1 2.2 2.1 2.2 Day 59 1.9 2.4 2.1 2.4 2.1 2.4 2.2 2.1 2.2 2.3 2.2 2.7 1.9 2.0 2.2 2.1 2.5 2.3 2.1 2.2 2.0 2.1 2.0 2.3 2.2 2.1 2.2 2.0 2.3 2.1 1.7 2.1 2.2 2.1 2.2 Company Sanitized. Does not contain TSCA CBI -503- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Female, VI - 100 mg/kg/day 646608 1.9 1.9 646556 2.4 2.4 646629 2.1 2.1 646510 2.4 2.4 646578 2.1 2.1 646505 2.4 2.4 646534 2.2 2.2 646624 2.1 2.1 646501 2.2 2.2 646633 2.3 2.3 646656 2.2 2.2 646630 2.7 2.7 646634 1.9 1.9 646533 2.0 2.0 646632 2.2 2.2 646547 2.1 2.1 646666 2.5 2.5 646607 2.3 2.3 646524 2.1 2.1 646600 2.2 2.2 646648 2.0 2.0 646594 2.1 2.1 646546 2.0 2.0 646661 2.3 2.3 646671 2.2 2.2 646521 2.1 2.1 646590 2.2 2.2 646645 2.0 2.0 646555 2.3 2.3 646605 2.1 2.1 646589 1.7 1.7 646615 2.1 2.1 646527 2.2 2.2 646647 2.1 2.1 646675 2.2 2.2 Day 62 1.9 2.4 2.1 2.4 2.1 2.4 2.2 2.1 2.2 2.3 2.2 2.7 1.9 2.0 2.2 2.1 2.5 2.3 2.1 2.2 2.0 2.1 2.0 2.3 2.2 2.1 2.2 2.0 2.3 2.1 1.7 2.1 2.2 2.1 2.2 Day 63 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 64 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 65 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 66 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 67 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 68 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 69 2.0 2.4 2.1 2.5 2.2 2.5 2.2 2.1 2.2 2.3 2.2 2.8 1.9 2.1 2.1 2.1 2.6 2.3 2.1 2.3 2.0 2.2 2.1 2.3 2.1 2.2 2.2 2.0 2.4 2.2 1.8 2.1 2.2 2.2 2.3 Day 70 2.0 2.5 2.1 2.5 2.3 2.5 2.3 2.3 2.3 2.3 2.2 2.8 2.0 2.0 2.3 2.2 2.6 2.3 2.1 2.2 2.0 2.2 2.1 2.4 2.3 2.2 2.3 2.0 2.4 2.3 1.9 2.1 2.2 2.2 2.3 Day 71 2.0 2.5 2.1 2.5 2.3 2.5 2.3 2.3 2.3 2.3 2.2 2.8 2.0 2.0 2.3 Company Sanitized. Does not contain TSCA CBI -504- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Female, VI - 100 mg/kg/day 646608 2.0 2.0 646556 2.5 2.5 646629 2.1 2.1 646510 2.5 2.5 646578 2.3 2.3 646505 2.5 2.5 646534 2.3 2.3 646624 2.3 2.3 646501 2.3 2.3 646633 2.3 2.3 646656 2.2 2.2 646630 2.8 2.8 646634 2.0 2.0 646533 2.0 2.0 646632 2.3 2.3 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 Day 74 2.0 2.5 2.1 2.5 2.3 2.5 2.3 2.3 2.3 2.3 2.2 2.8 2.0 2.0 2.3 Day 75 2.0 2.5 2.1 2.5 2.3 2.5 2.3 2.3 2.3 2.3 2.2 2.8 2.0 2.0 2.3 Day 76 2.0 2.5 2.1 2.5 2.3 2.5 2.3 2.3 2.3 2.3 2.2 2.8 2.0 2.0 2.3 Day 77 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 78 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 79 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 80 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 81 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 82 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Day 83 2.0 2.5 2.2 2.4 2.2 2.6 2.3 2.3 2.3 2.3 2.2 2.8 1.9 2.1 2.3 Company Sanitized. Does not contain TSCA CBI -505. )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Female, VI - 100 mg/kg/day 646608 2.1 2.1 646556 2.6 2.6 646629 2.2 2.2 646510 2.5 2.5 646578 2.3 2.3 646505 2.7 2.7 646534 2.3 2.3 646624 2.4 2.4 646501 2.4 2.4 646633 2.4 2.4 646656 2.3 2.3 646630 2.9 2.9 646634 2.0 2.0 646533 2.1 2.1 646632 2.3 2.3 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 Day 86 2.1 2.6 2.2 2.5 2.3 2.7 2.3 2.4 2.4 2.4 2.3 2.9 2.0 2.1 2.3 Day 87 2.1 2.6 2.2 2.5 2.3 2.7 2.3 2.4 2.4 2.4 2.3 2.9 2.0 2.1 2.3 Day 88 2.1 2.6 2.2 2.5 2.3 2.7 2.3 2.4 2.4 2.4 2.3 2.9 2.0 2.1 2.3 Day 89 2.1 2.6 2.2 2.5 2.3 2.7 2.3 2.4 2.4 2.4 2.3 2.9 2.0 2.1 2.3 Day 90 2.1 2.6 2.2 2.5 2.3 2.7 2.3 2.4 2.4 2.4 2.3 2.9 2.0 2.1 2.3 Day 91 2.1 2.6 2.2 2.5 2.4 2.7 2.4 2.3 2.4 2.4 Day 92 2.1 2.6 2.2 2.5 2.4 2.7 2.4 2.3 2.4 2.4 Day 93 2.1 2.6 2.2 2.5 2.4 2.7 2.4 2.3 2.4 2.4 Day 94 2.1 2.6 2.2 2.5 2.4 2.7 2.4 2.3 2.4 2.4 Day 95 2.1 2.6 2.2 2.5 2.4 2.7 2.4 2.3 2.4 2.4 Company Sanitized. Does not contain TSCA CBI -506- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Day 2 Female, VIII - 500 mg/kg/day 646657 1.4 1.4 1.4 646610 1.2 1.2 1.2 646536 1.5 1.5 1.5 646593 1.3 1.3 1.3 646509 1.3 1.3 1.3 646669 1.4 1.4 1.4 646614 1.2 1.2 1.2 646609 1.6 1.6 1.6 646577 1.2 1.2 1.2 646535 1.4 1.4 1.4 646667 1.4 1.4 1.4 646523 1.2 1.2 1.2 646528 1.4 1.4 1.4 646601 1.4 1.4 1.4 646620 1.4 1.4 1.4 646662 1.1 1.1 1.1 646583 1.3 1.3 1.3 646623 1.3 1.3 1.3 646619 1.3 1.3 1.3 646539 1.4 1.4 1.4 646628 1.2 1.2 1.2 646616 1.4 1.4 1.4 646563 1.3 1.3 1.3 646641 1.4 1.4 1.4 646572 1.2 1.2 1.2 646512 1.5 1.5 1.5 646566 1.2 1.2 1.2 646570 1.3 1.3 1.3 646602 1.3 1.3 1.3 646582 1.3 1.3 1.3 646655 1.3 1.3 1.3 646663 1.2 1.2 1.2 646640 1.2 1.2 1.2 646574 1.3 1.3 1.3 646532 1.5 1.5 1.5 646540 1.3 1.3 1.3 646548 1.4 1.4 1.4 646508 1.4 1.4 1.4 646650 1.3 1.3 1.3 646637 1.4 1.4 1.4 646545 1.3 1.3 1.3 646618 1.3 1.3 1.3 646506 1.3 1.3 1.3 646542 1.4 1.4 1.4 646599 1.3 1.3 1.3 Day 3 1.4 1.2 1.5 1.3 1.3 1.4 1.2 1.6 1.2 1.4 1.4 1.2 1.4 1.4 1.4 1.1 1.3 1.3 1.3 1.4 1.2 1.4 1.3 1.4 1.2 1.5 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.3 1.5 1.3 1.4 1.4 1.3 1.4 1.3 1.3 1.3 1.4 1.3 Day 4 1.4 1.2 1.5 1.3 1.3 1.4 1.2 1.6 1.2 1.4 1.4 1.2 1.4 1.4 1.4 1.1 1.3 1.3 1.3 1.4 1.2 1.4 1.3 1.4 1.2 1.5 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.3 1.5 1.3 1.4 1.4 1.3 1.4 1.3 1.3 1.3 1.4 1.3 Day 5 1.4 1.2 1.5 1.3 1.3 1.4 1.2 1.6 1.2 1.4 1.4 1.2 1.4 1.4 1.4 1.1 1.3 1.3 1.3 1.4 1.2 1.4 1.3 1.4 1.2 1.5 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.3 1.5 1.3 1.4 1.4 1.3 1.4 1.3 1.3 1.3 1.4 1.3 Day 6 1.4 1.2 1.5 1.3 1.3 1.4 1.2 1.6 1.2 1.4 1.4 1.2 1.4 1.4 1.4 1.1 1.3 1.3 1.3 1.4 1.2 1.4 1.3 1.4 1.2 1.5 1.2 1.3 1.3 1.3 1.3 1.2 1.2 1.3 1.5 1.3 1.4 1.4 1.3 1.4 1.3 1.3 1.3 1.4 1.3 Day 7 1.5 1.3 1.8 1.2 1.4 1.3 1.4 1.5 1.3 1.4 1.5 1.3 1.4 1.5 1.4 1.2 1.4 1.5 1.5 1.5 1.3 1.4 1.3 1.4 1.3 1.5 1.3 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.3 1.3 1.5 1.4 1.-4 1.3 1.4 1.3 1.5 1.4 Day 8 1.5 1.3 1.8 1.2 1.4 1.3 1.4 1.5 1.3 1.4 1.5 1.3 1.4 1.5 1.4 1.2 1.4 1.5 1.5 1.5 1.3 1.4 1.3 1.4 1.3 1.5 1.3 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.3 1.3 1.5 1.4 1.4 1.3 1.4 1.3 1.5 1.4 Day 9 1.5 1.3 1.8 1.2 1.4 1.3 1.4 1.5 1.3 1.4 1.5 1.3 1.4 1.5 1.4 1.2 1.4 1.5 1.5 1.5 1.3 1.4 1.3 1.4 1.3 1.5 1.3 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.3 1.3 1.5 1.4 1.4 1.3 1.4 1.3 1.5 1.4 Day 10 1.5 1.3 1.8 1.2 1.4 1.3 1.4 1.5 1.3 1.4 1.5 1.3 1.4 1.5 1.4 1.2 1.4 1.5 1.5 1.5 1.3 1.4 1.3 1.4 1.3 1.5 1.3 1.3 1.3 1.4 1.4 1.2 1.2 1.4 1.5 1.3 1.3 1.5 1.4 1.4 1.3 1.4 1.3 1.5 1.4 Day 11 1. 5 1. 3 1. 8 1. 2 1. 4 1. 3 1. 4 1. 5 1. 3 1. 4 1. 5 1. 3 1. 4 1. 5 1. 4 1. 2 1. 4 1. 5 1. 5 1. 5 1. 3 1. 4 1. 3 1. 4 1. 3 1. 5 1. 3 1. 3 1. 3 1. 4 1. 4 1. 2 1. 2 1. 4 1. 5 1. 3 1. 3 1. 5 1. 4 1. 4 1. 3 1. 4 1. 3 1. 5 1. 4 Company Sanitized. Does not contain TSCA H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Day 14 Female, VIII - 500 mg/kg/day 646657 1.5 1.5 1.7 646610 1.3 1.3 1.5 646536 1.8 1.8 1.9 646593 1.2 1.2 1.4 646509 1.4 1.4 1.6 646669 1.3 1.3 1.5 646614 1.4 1.4 1.6 646609 1.5 1.5 1.7 646577 1.3 1.3 1.4 646535 1.4 1.4 1.6 646667 1.5 1.5 1.6 646523 1.3 1.3 1.3 646528 1.4 1.4 1.6 646601 1.5 1.5 1.6 646620 1.4 1.4 1.5 646662 1.2 1.2 1.3 646583 1.4 1.4 1.5 646623 1.5 1.5 1.7 646619 1.5 1.5 1.6 646539 1.5 1.5 1.7 646628 1.3 1.3 1.6 646616 1.4 1.4 1.6 646563 1.3 1.3 1.5 646641 1.4 1.4 1.6 646572 1.3 1.3 1.4 646512 1.5 1.5 1.7 646566 1.3 1.3 1.4 646570 1.3 1.3 1.5 646602 1.3 1.3 1.5 646582 1.4 1.4 1.6 646655 1.4 1.4 1.6 646663 1.2 1.2 1.4 646640 1.2 1.2 1.4 646574 1.4 1.4 1.7 646532 1.5 1.5 1.6 646540 1.3 1.3 1.5 646548 1.3 1.3 1.6 646508 1.5 1.5 1.8 646650 1.4 1.4 1.6 646637 1.4 1.4 1.6 646545 1.3 1.3 1.5 646618 1.4 1.4 1.6 646506 1.3 1.3 1.5 646542 1.5 1.5 1.8 646599 1.4 1.4 1.6 Day 15 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 16 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 17 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 18 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 19 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 20 1.7 1.5 1.9 1.4 1.6 1.5 1.6 1.7 1.4 1.6 1.6 1.3 1.6 1.6 1.5 1.3 1.5 1.7 1.6 1.7 1.6 1.6 1.5 1.6 1.4 1.7 1.4 1.5 1.5 1.6 1.6 1.4 1.4 1.7 1.6 1.5 1.6 1.8 1.6 1.6 1.5 1.6 1.5 1.8 1.6 Day 21 1.9 1.6 2.1 1.6 1.9 1.7 1.7 1.9 1.6 1.7 1.8 1.5 1.8 1.8 1.6 1.5 1.7 1.8 1.8 1.9 1.7 1.8 1.7 1.8 1.5 1.9 1.6 1.6 1.6 1.7 1.7 1.6 1.5 1.8 1.8 1.7 1.7 1.8 1.7 1.8 1.7 1.8 1.6 1.9 1.7 Day 22 1.9 1.6 2.1 1.6 1.9 1.7 1.7 1.9 1.6 1.7 1.8 1.5 1.8 1.8 1.6 1.5 1.7 1.8 1.8 1.9 1.7 1.8 1.7 1.8 1.5 1.9 1.6 1.6 1.6 1.7 1.7 1.6 1.5 1.8 1.8 1.7 1.7 1.8 1.7 1.8 1.7 1.8 1.6 1.9 1.7 Day 23 1. 9 1. 6 2. 1 1. 6 1. 9 1. 7 1. 7 1. 9 1. 6 1. 7 1. 8 1. 5 1. 8 1. 8 1. 6 1. 5 1. 7 1. 8 1. 8 1. 9 1. 7 1. 8 1. 7 1. 8 1. 5 1. 9 1. 6 1. 6 1. 6 1. 7 1. 7 1. 6 1. 5 1. 8 1. 8 1. 7 1. 7 1. 8 1. 7 1. 8 1. 7 1. 8 1. 6 1. 9 1. 7 Company Sanitized. Does not contain TSCA )> H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations_________________________________________________________ ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 24 Day 25 Day 26 Female, VIII - 500 mg/kg/day 646657 1.9 1.9 1.9 646610 1.6 1.6 1.6 646536 2.1 2.1 2.1 646593 1.6 1.6 1.6 646509 1.9 1.9 1.9 646669 1.7 1.7 1.7 646614 1.7 1.7 1.7 646609 1.9 1.9 1.9 646577 1.6 1.6 1.6 646535 1.7 1.7 1.7 646667 1.8 1.8 1.8 646523 1.5 1.5 1.5 646528 1.8 1.8 1.8 646601 1.8 1.8 1.8 646620 1.6 1.6 1.6 646662 1.5 1.5 1.5 646583 1.7 1.7 1.7 646623 1.8 1.8 1.8 646619 1.8 1.8 1.8 646539 1.9 1.9 1.9 646628 1.7 1.7 1.7 646616 1.8 1.8 1.8 646563 1.7 1.7 1.7 646641 1.8 1.8 1.8 646572 1.5 1.5 1.5 646512 1.9 1.9 1.9 646566 1.6 1.6 1.6 646570 1.6 1.6 1.6 646602 1.6 1.6 1.6 646582 1.7 1.7 1.7 646655 1.7 1.7 1.7 646663 1.6 1.6 1.6 646640 1.5 1.5 1.5 646574 1.8 1.8 1.8 646532 1.8 1.8 1.8 646540 1.7 1.7 1.7 646548 1.7 1.7 1.7 646508 1.8 1.8 1.8 646650 1.7 1.7 1.7 646637 1.8 1.8 1.8 646545 1.7 1.7 1.7 646618 1.8 1.8 1.8 646506 1.6 1.6 1.6 646542 1.9 1.9 1.9 646599 1.7 1.7 1.7 Day 27 1.9 1.6 2.1 1.6 1.9 1.7 1.7 1.9 1.6 1.7 1.8 1.5 1.8 1.8 1.6 1.5 1.7 1.8 1.8 1.9 1.7 1.8 1.7 1.8 1.5 1.9 1.6 1.6 1.6 1.7 1.7 1.6 1.5 1.8 1.8 1.7 1.7 1.8 1.7 1.8 1.7 1.8 1.6 1.9 1.7 Day 28 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 29 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 30 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 31 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 32 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 33 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 34 2.0 1.7 2.1 1.6 1.9 1.8 1.9 2.0 1.6 1.9 1.8 1.6 1.9 2.0 1.7 1.5 1.8 2.0 2.0 2.0 1.9 1.9 1.8 1.9 1.5 2.0 1.7 1.8 1.7 1.9 1.9 1.7 1.7 1.9 1.9 1.8 1.9 2.0 1.9 2.0 1.8 2.0 1.7 2.1 1.9 Day 35 2.1 1.8 2.2 1.6 2.0 1.8 1.9 2.2 1.7 2.0 1.9 1.6 2.0 2.0 1.8 1.6 1.9 2.0 2.1 2.2 2.0 1.9 1.9 2.1 1.6 2.1 1.8 1.8 1.8 1.9 2.0 1.8 1.7 1.9 1.9 1.9 1.9 2.1 1.9 2.0 1.8 2.0 1.8 2.1 1.9 -509- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Day 38 Female, VIII - 500 mg/kg/day 646657 2.1 2.1 2.1 646610 1.8 1.8 1.8 646536 2.2 2.2 2.2 646593 1.6 1.6 1.6 646509 2.0 2.0 2.0 646669 1.8 1.8 1.8 646614 1.9 1.9 1.9 646609 2.2 2.2 2.2 646577 1.7 1.7 1.7 646535 2.0 2.0 2.0 646667 1.9 1.9 1.9 646523 1.6 1.6 1.6 646528 2.0 2.0 2.0 646601 2.0 2.0 2.0 646620 1.8 1.8 1.8 646662 1.6 1.6 1.6 646583 1.9 1.9 1.9 646623 2.0 2.0 2.0 646619 2.1 2.1 2.1 646539 2.2 2.2 2.2 646628 2.0 2.0 2.0 646616 1.9 1.9 1.9 646563 1.9 1.9 1.9 646641 2.1 2.1 2.1 646572 1.6 1.6 1.6 646512 2.1 2.1 2.1 646566 1.8 1.8 1.8 646570 1.8 1.8 1.8 646602 1.8 1.8 1.8 646582 1.9 1.9 1.9 646655 2.0 2.0 2.0 646663 1.8 1.8 1.8 646640 1.7 1.7 1.7 646574 1.9 1.9 1.9 646532 1.9 1.9 1.9 646540 1.9 1.9 1.9 646548 1.9 1.9 1.9 646508 2.1 2.1 2.1 646650 1.9 1.9 1.9 646637 2.0 2.0 2.0 646545 1.8 1.8 1.8 646618 2.0 2.0 2.0 646506 1.8 1.8 1.8 646542 2.1 2.1 2.1 646599 1.9 1.9 1.9 Day 39 2.1 1.8 2.2 1.6 2.0 1.8 1.9 2.2 1.7 2.0 1.9 1.6 2.0 2.0 1.8 1.6 1.9 2.0 2.1 2.2 2.0 1.9 1.9 2.1 1.6 2.1 1.8 1.8 1.8 1.9 2.0 1.8 1.7 1.9 1.9 1.9 1.9 2.1 1.9 2.0 1.8 2.0 1.8 2.1 1.9 Day 40 2.1 1.8 2.2 1.6 2.0 1.8 1.9 2.2 1.7 2.0 1.9 1.6 2.0 2.0 1.8 1.6 1.9 2.0 2.1 2.2 2.0 1.9 1.9 2.1 1.6 2.1 1.8 1.8 1.8 1.9 2.0 1.8 1.7 1.9 1.9 1.9 1.9 2.1 1.9 2.0 1.8 2.0 1.8 2.1 1.9 Day 41 Day 42 2.1 1.8 2.2 1.6 2.0 1.8 1.9 2.2 1.7 2.0 1.9. 1.6 2.0 2.0 1.8 1.6 1.9 2.0 2.1 2.2 2.0 1.9 1.9 2.1 1.6 2.1 1.8 1.8 1.8 1.9 2.0 1.8 1.7 1.9 1.9 1.9 1.9 2.1 1.9 2.0 1.8 2.0 1.8 2.1 1.9 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 2.0 Day 43 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 2.0 Day 44 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 2.0 Day 45 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 2.0 Day 46 Day 47 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 .d 2.2 1.9 2.3 1.7 2.1 1.8 2.0 2.2 1.7 2.0 2.0 1.7 2.1 2.1 1.9 1.7 2.0 2.1 2.2 2.2 2.1 1.9 2.0 2.1 1.7 2.1 1.9 1.9 1.9 2.1 2.0 1.9 1.8 2.1 2.1 2.0 1.9 2.2 2.0 2.1 1.9 2.1 1.9 2.2 2.0 Company Sanitized. Does not contain TSCA CBI -510- ) )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 48 Day 49 Day 50 Female, VIII - 500 mg/kg/day 646657 2.2 2.3 2.3 646610 1.9 2.0 2.0 646536 2.3 2.4 2.4 646593 1.7 1.8 1.8 646509 2.1 2.3 2.3 646669 1.8 2.0 2.0 646614 2.0 2.1 2.1 646609 2.2 2.3 2.3 646577 1.7 1.8 1.8 646535 2.0 2.1 2.1 646667 2.0 2.1 2.1 646523 1.7 1.7 1.7 646528 2.1 2.2 2.2 646601 2.1 2.2 2.2 646620 1.9 1.9 1.9 646662 1.7 1.7 1.7 646583 2.0 2.0 2.0 646623 2.1 2.2 2.2 646619 2.2 2.4 2.4 646539 2.2 2.4 2.4 646628 2.1 2.1 2.1 646616 1.9 2.0 2.0 646563 2.0 2.0 2.0 646641. 2.1 2.2 2.2 646572 1.7 1.7 1.7 646512 2.1 2.2 2.2 646566 1.9 1.9 1.9 646570 1.9 2.0 2.0 646602 1.9 1.9 1.9 646582 2.1 2.1 2.1 646655 2.0 2.0 2.0 646663 1.9 1.9 1.9 646640 1.8 1.9 1.9 646574 2.1 2.1 2.1 646532 2.1 2.1 2.1 646540 2.0 2.0 2.0 646548 1.9 2.0 2.0 646508 2.2 2.3 2.3 646650 2.0 2.0 2.0 646637 2.1 2.1 2.1 646545 1.9 2.0 2.0 646618 2.1 2.1 2.1 646506 1.9 1.9 1.9 646542 2.2 2.2 2.2 646599 2.0 2.1 2.1 Day 51 2.3 2.0 2.4 1.8 2.3 2.0 2.1 2.3 1.8 2.1 2.1 1.7 2.2 2.2 1.9 1.7 2.0 2.2 2.4 2.4 2.1 2.0 2.0 2.2 1.7 2.2 1.9 2.0 1.9 2.1 2.0 1.9 1.9 2.1 2.1 2.0 2.0 2.3 2.0 2.1 2.0 2.1 1.9 2.2 2.1 Day 52 2.3 2.0 2.4 1.8 2.3 2.0 2.1 2.3 1.8 2.1 2.1 1.7 2.2 2.2 1.9 1.7 2.0 2.2 2.4 2.4 2.1 2.0 2.0 2.2 1.7 2.2 1.9 2.0 1.9 2.1 2.0 1.9 1.9 2.1 2.1 2.0 2.0 2.3 2.0 2.1 2.0 2.1 1.9 2.2 2.1 Day 53 2.3 2.0 2.4 1.8 2.3 2.0 2.1 2.3 1.8 2.1 2.1 1.7 2.2 2.2 1.9 1.7 2.0 2.2 2.4 2.4 2.1 2.0 2.0 2.2 1.7 2.2 1.9 2.0 1.9 2.1 2.0 1.9 1.9 2.1 2.1 2.0 2.0 2.3 2.0 2.1 2.0 2.1 1.9 2.2 2.1 Day 54 2.3 2.0 2.4 1.8 2.3 2.0 2.1 2.3 1.8 2.1 2.1 1.7 2.2 2.2 1.9 1.7 2.0 2.2 2.4 2.4 2.1 2.0 2.0 2.2 1.7 2.2 1.9 2.0 1.9 2.1 2.0 1.9 1.9 2.1 2.1 2.0 2.0 2.3 2.0 2.1 2.0 2.1 1.9 2.2 2.1 Day 55 2.3 2.0 2.4 1.8 2.3 2.0 2.1 2.3 1.8 2.1 2.1 1.7 2.2 2.2 1.9 1.7 2.0 2.2 2.4 2.4 2.1 2.0 2.0 2.2 1.7 2.2 1.9 2.0 1.9 2.1 2.0 1.9 1.9 2.1 2.1 2.0 2.0 2.3 2.0 2.1 2.0 2.1 1.9 2.2 2.1 Day 56 2.3 2.0 2.4 1.8 2.2 2.0 2.2 2.3 1.9 2.2 2.1 1.8 2.2 2.2 2.0 1.8 2.1 2.2 2.4 2.4 2.3 2.1 2.1 2.3 1.8 2.2 1.9 2.0 2.0 2.1 2.2 1.9 1.9 2.1 2.2 2.1 2.0 2.3 2.1 2.2 2.0 2.2 2.0 2.3 2.0 Day 57 2.3 2.0 2.4 1.8 2.2 2.0 2.2 2.3 1.9 2.2 2.1 1.8 2.2 2.2 2.0 1.8 2.1 2.2 2.4 2.4 2.3 2.1 2.1 2.3 1.8 2.2 1.9 2.0 2.0 2.1 2.2 1.9 1.9 2.1 2.2 2.1 2.0 2.3 2.1 2.2 2.0 2.2 2.0 2.3 2.0 Day 58 2.3 2.0 2.4 1.8 2.2 2.0 2.2 2.3 1.9 2.2 2.1 1.8 2.2 2.2 2.0 1.8 2.1 2.2 2.4 2.4 2.3 2.1 2.1 2.3 1.8 2.2 1.9 2.0 2.0 2.1 2.2 1.9 1.9 2.1 2.2 2.1 2.0 2.3 2.1 2.2 2.0 2.2 2.0 2.3 2.0 Day 59 2.3 2.0 2.4 1.8 2.2 2.0 2.2 2.3 1.9 2.2 2.1 1.8 2.2 2.2 2.0 1.8 2.1 2.2 2.4 2.4 2.3 2.1 2.1 2.3 1.8 2.2 1.9 2.0 2.0 2.1 2.2 1.9 1.9 2.1 2.2 2.1 2.0 2.3 2.1 2.2 2.0 2.2 2.0 2.3 2.0 -511- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 60 Day 61 Day 62 Female, VIII - 500 mg/kg/day 646657 2.3 2.3 2.3 646610 2.0 2.0 2.0 646536 2.4 2.4 2.4 646593 1.8 1.8 1.8 646509 2.2 2.2 2.2 646669 2.0 2.0 2.0 646614 2.2 2.2 2.2 646609 2.3 2.3 2.3 646577 1.9 1.9 1.9 646535 2.2 2.2 2.2 646667 2.1 2.1 2.1 646523 1.8 1.8 1.8 646528 2.2 2.2 2.2 646601 2.2 2.2 2.2 646620 2.0 2.0 2.0 646662 1.8 1.8 1.8 646583 2.1 2.1 2.1 646623 2.2 2.2 2.2 646619 2.4 2.4 2.4 646539 2.4 2.4 2.4 646628 2.3 2.3 2.3 646616 2.1 2.1 2.1 646563 2.1 2.1 2.1 646641 2.3 2.3 2.3 646572 1.8 1.8 1.8 646512 2.2 2.2 2.2 646566 1.9 1.9 1.9 646570 2.0 2.0 2.0 646602 2.0 2.0 2.0 646582 2.1 2.1 2.1 646655 2.2 2.2 2.2 646663 1.9 1.9 1.9 646640 1.9 1.9 1.9 646574 2.1 2.1 2.1 646532 2.2 2.2 2.2 646540 2.1 2.1 2.1 646548 2.0 2.0 2.0 646508 2.3 2.3 2.3 646650 2.1 2.1 2.1 646637 2.2 2.2 2.2 646545 2.0 2.0 2.0 646618 2.2 2.2 2.2 646506 2.0 2.0 2.0 646542 2.3 2.3 2.3 646599 2.0 2.0 2.0 Day 63 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 64 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 65 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 66 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 67 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 68 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 69 2.4 2.0 2.5 1.8 2.3 2.0 2.3 2.4 1.9 2.2 2.1 1.8 2.2 2.3 2.1 1.8 2.1 2.2 2.4 2.4 2.3 2.0 2.1 2.3 1.8 2.2 2.0 2.1 2.0 2.1 2.2 2.0 1.9 2.2 2.1 2.1 2.0 2.4 2.2 2.2 2.1 2.2 2.0 2.3 2.1 Day 70 2.4 2.1 2.4 1.8 2.3 2.1 2.2 2.4 1.9 2.2 2.2 1.8 2.3 2.3 2.1 1.8 2.2 2.2 2.5 2.5 2.2 2.1 2.2 2.4 1.8 2.2 2.0 2.1 2.1 2.2 2.2 2.1 2.0 2.2 2.2 2.1 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.0 Day 71 2. 4 2. 1 2. 4 1. 8 2. 3 2. 1 2. 2 2. 4 1. 9 2. 2 2. 2 1. 8 2. 3 2. 3 2. 1 2. 1 2. 1 2. 4 2. 2 2. 3 2. 1 2. 3 2. 1 2. 4 2. 0 -512- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Day 74 Female, VIII - 500 mg/kg/day 646657 2.4 2.4 2.4 646610 2.1 2.1 2.1 646536 2.4 2.4 2.4 646593 1.8 1.8 1.8 646509 2.3 2.3 2.3 646669 2.1 2.1 2.1 646614 2.2 2.2 2.2 646609 2.4 2.4 2.4 646577 1.9 1.9 1.9 646535 2.2 2.2 2.2 646667 2.2 2.2 2.2 646523 1.8 1.8 1.8 646528 2.3 2.3 2.3 646601 2.3 2.3 2.3 646620 2.1 2.1 2.1 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 2.1 2.1 2.1 646548 2.1 2.1 2.1 646508 2.4 2.4 2.4 646650 2.2 2.2 2.2 646637 2.3 2.3 2.3 646545 2.1 2.1 2.1 646618 2.3 2.3 2.3 646506 2.1 2.1 2.1 646542 2.4 2.4 2.4 646599 2.0 2.0 2.0 Day 75 2.4 2.1 2.4 1.8 2.3 2.1 2.2 2.4 1.9 2.2 2.2 1.8 2.3 2.3 2.1 2.1 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.0 Day 76 2.4 2.1 2.4 1.8 2.3 2.1 2.2 2.4 1.9 2.2 2.2 1.8 2.3 2.3 2.1 2.1 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.0 Day 77 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 78 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 79 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 80 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 81 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 82 2.4 2.2 2.5 1.9 2.4 2.1 2.2 2.5 1.9 2.2 2.2 1.9 2.3 2.3 2.1 2.2 2.1 2.4 2.2 2.3 2.1 2.3 2.1 2.4 2.1 Day 83 2. 4 2. 2 2. 5 1. 9 2. 4 2. 1 2. 2 2. 5 1. 9 2. 2 2. 2 1. 9 2. 3 2. 3 2. 1 22 21 24 22 23 21 23 21 24 21 -513- H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Day 86 Female VIII - 500 mg/kg/day 646657 2.5 2.5 2.5 646610 2.2 2.2 2.2 646536 2.5 2.5 2.5 646593 2.0 2.0 2.0 646509 2.4 2.4 2.4 646669 2.1 2.1 2.1 646614 2.3 2.3 2.3 646609 2.5 2.5 2.5 646577 1.9 1.9 1.9 646535 2.2 2.2 2.2 646667 2.2 2.2 2.2 646523 2.0 2.0 2.0 646528 2.3 2.3 2.3 646601 2.3 2.3 2.3 646620 2.2 2.2 2.2 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 2.2 2.2 2.2 646548 2.2 2.2 2.2 646508 2.5 2.5 2.5 646650 2.3 2.3 2.3 646637 2.3 2.3 2.3 646545 2.1 2.1 2.1 646618 2.3 2.3 2.3 646506 2.1 2.1 2.1 646542 2.5 2.5 2.5 646599 2.1 2.1 2.1 Day 87 2.5 2.2 2.5 2.0 2.4 2.1 2.3 2.5 1.9 2.2 2.2 2.0 2.3 2.3 2.2 2.2 2.2 2.5 2.3 2.3 2.1 2.3 2.1 2.5 2.1 Day 88 2.5 2.2 2.5 2.0 2.4 2.1 2.3 2.5 1.9 2.2 2.2 2.0 2.3 2.3 2.2 2.2 2.2 2.5 2.3 2.3 2.1 2.3 2.1 2.5 2.1 Day 89 2.5 2.2 2.5 2.0 2.4 2.1 2.3 2.5 1.9 2.2 2.2 2.0 2.3 2.3 2.2 2.2 2.2 2.5 2.3 2.3 2.1 2.3 2.1 2.5 2.1 Day 90 2.5 2.2 2.5 2.0 2.4 2.1 2.3 2.5 1.9 2.2 2.2 2.0 2.3 2.3 2.2 2.2 2.2 2.5 2.3 2.3 2.1 2.3 2.1 2.5 2.1 Day 91 2.4 2.2 2.4 2.0 2.3 2.1 2.3 2.6 2.0 2.3 Day 92 2.4 2.2 2.4 2.0 2.3 2.1 2.3 2.6 2.0 2.3 Day 93 2.4 2.2 2.4 2.0 2.3 2.1 2.3 2.6 2.0 2.3 Day 94 2.4 2.2 2.4 2.0 2.3 2.1 2.3 2.6 2.0 2.3 Day 95 2.4 2.2 2.4 2.0 2.3 2.1 2.3 2.6 2.0 2.3 -514- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX C INDIVIDUAL BODY WEIGHTS -515Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Critical Dates INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES Day 70 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 91 Last day o f non-fasted body weight data collection for male and female rats designated for the 91-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designated for 91-day exposure period were sacrificed. Day 119 Last day of non-fasted body weight data collection for rats designated for the one- month recovery period. Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 182 Last day of non-fasted body weight data collection for rats designated for the 3-month recovery period. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis -516Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations Day 0 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 196.9 230.7 232.5 240.6 228.9 222.3 214.1 227.8 211.7 231.2 217.9 213.5 188.5 206.1 198.1 208.2 227.0 238.1 228.2 213.5 207.3 206.6 206.9 231.0 217.6 252.7 212.1 219.5 204.2 214.8 198.0 212.3 215.9 228.8 208.8 196.7 207.2 199.7 236.6 196.6 201.4 216.4 232.2 211.8 196.8 Day 7 247.8 277.8 289.3 309.5 286.6 281.5 281.2 297.1 264.1 284.6 273.8 262.9 221.6 252.5 248.1 256.9 284.5 302.9 286.6 277.8 263.2 261.2 268.2 290.8 279.4 328.1 269.6 276.5 248.4 282.0 248.9 266.9 267.7 274.4 255.3 255.6 254.2 235.2 318.0 248.2 254.7 275.9 293.4 269.6 260.4 Day 14 300.8 325.6 357.0 374.0 338.9 326.9 339.2 359.9 305.7 340.7 320.6 319.0 250.7 288.7 299.3 302.3 331.1 359.9 344.6 331.4 319.7 194.9 323.7 347.2 331.2 397.6 317.9 326.3 283.3 341.4 298.9 311.7 312.8 325.5 298.3 304.7 308.8 273.1 401.5 300.9 305.8 324.6 348.5 318.9 320.5 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 348.5 361.7 421.3 433.9 378.6 377.2 399.6 413.9 354.8 394.3 367.3 369.2 280.7 337.4 335.9 338.5 374.6 411.0 396.3 381.6 376.9 294.5 374.0 395.6 388.9 472.7 356.6 364.7 323.6 394.5 341.5 358.1 357.7 369.3 324.1 350.7 355.8 308.4 469.1 343.4 354.7 367.5 399.6 376.0 376.4 383.1 397.9 471.2 481.8 412.0 419.8. 456.6 458.4 395.6 434.8 401.6 413.7 303.4 375.4 360.1 360.3 405.0 446.2 439.0 422.9 414.1 352.1 421.1 427.2 427.7 516.0 398.3 398.3 354.2 443.8 376.3 392.6 391.9 406.1 348.6 387.4 401.9 340.1 514.2 387.5 397.9 406.3 446.3 419.3 427.1 419.1 431.7 507.3 531.1 438.1 431.9 492.2 496.8 424.5 482.3 423.9 446.4 321.0 402.5 389.0 377.4 436.6 469.4 465.4 461.0 455.5 381.0 458.5 453.5 469.2 562.6 435.8 435.7 381.8 468.0 416.3 418.2 419.9 439.3 370.5 417.1 437.3 358.7 569.1 412.1 417.5 438.2 477.2 445.9 471.5 432.2 444.7 529.3 545.7 453.0 445.2 499.7 521.4 430.9 522.5 447.1 467.7 331.8 423.4 408.9 399.2 456.6 499.3 497.5 486.8 480.3 416.5 480.8 475.9 505.3 599.6 469.7 463.4 406.7 501.1 431.6 443.0 445.8 475.8 391.6 441.2 457.2 374.0 610.4 438.1 449.6 457.9 498.9 477.1 491.9 Day 49 452.8 472.3 560.4 584.1 484.4 463.9 534.3 555.0 453.8 558.5 462.9 496.7 349.7 450.4 433.8 425.6 480.1 525.1 524.7 525.2 507.0 437.2 504.1 508.1 531.4 631.0 491.5 489.3 429.2 523.5 447.7 470.1 476.0 494.3 412.1 456.7 485.0 392.4 635.2 454.7 468.8 474.9 515.0 496.7 518.1 DuPont-5990 Day 56 467. 3 492. 3 593. 7 611. 1 513. 0 489. 0 556. 2 581. 8 472. 7 562. 3 468. 9 514. 6 349. 1 476. 2 446. 8 455. 1 499. 2 546. 2 549. 2 568. 3 532. 3 453. 7 526. 4 524. 2 563. 2 659. 8 517. 3 504. 2 437. 0 557. 6 458. 6 486. 8 500. 3 518. 2 434. 7 480. 0 506. 3 399. 2 662. 4 479. 1 499. 8 484. 9 543. 5 513. 7 543. 6 Company Sanitized. Does not contain TSCA CBI -517- Company Sanitized. Does not contain TSCA CBI ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) Day 63 Day 70 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 486.3 499.9 501.6 521.3 614.5 638.6 616.4 623.8 532.4 550.4 499.3 510.2 576.8 602.1 609.1 622.7 485.7 503.2 SE TEST DAY 57 475.1 485.1. 524.4 544.9 352.3 354.5 495.1 511.4 461.4 480.7 472.2 484.5 515.1 520.4 557.1 565.2 573.9 589.4 589.6 612.1 550.5 569.2 474.6 487.6 551.8 558.7 554.3 564.3 581.5 598.2 689.4 707.5 531.1 549.7 519.0 538.3 450.7 461.2 567.9 595.8 473.5 489.0 510.1 521.2 519.4 530.9 535.2 557.7 455.6 469.8 492.0 503.9 518.4 527.4 404.8 415.9 686.8 698.8 493.0 516.9 515.9 530.8 507.9 522.1 555.8 560.1 534.1 542.2 564.8 590.8 Day 77 501.5 528.6 650.4 643.8 575.6 530.6 610.4 639.0 519.9 496.8 562.6 359.1 523.9 484.1 509.8 535.7 422.2 715.8 512.3 547.1 533.5 577.3 562.6 605.3 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 513.9 543.0 667.4 642.6 589.0 540.7 621.1 662.7 527.2 504.6 578.4 358.6 537.1 533.7 550.4 676.9 658.2 604.9 559.2 630.7 674.1 544.6 508.4 562.6 369.1 542.5 510.5 562.9 372.1 557.7 502.0 574.5 381.7 560.6 490.6 519.6 548.1 435.0 728.5 524.6 545.4 544.3 593.3 569.3 622.7 498.3 529.8 555.8 453.2 730.9 532.3 545.7 552.4 598.4 577.2 642.3 -518- 509.5 540.0 570.4 459.3 752.4 543.3 560.0 573.7 616.0 590.1 524.4 549.3 582.1 469.1 767.6 557.5 576.9 580.6 631.1 610.5 Day 112 516.3 592.5 388.7 571.8 536.5 559.1 586.4 477.0 779.2 564.8 588.2 590.8 637.1 620.1 I DuPont-5990 Day 119 530.9 593.0 394.2 583.0 544.2 561.8 593.6 476.1 784.3 578.7 583.0 593.8 643.8 621.7 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations Day 126 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 535.3 613.0 406.8 602.0 Day 133 543.2 626.5 412.7 618.5 Day 140 INDIVIDUAL BODY WEIGHTS (g) Day 147 Day 154 Day 161 Day 168 553.0 637.7 418.8 631.8 551.3 604.9 418.2 639.1 554.2 601.4 424.9 652.2 570.3 620.3 433.9 668.3 587.7 620.8 435.3 682.7 Day 175 576.9 616.4 437.9 680.6 DuPont-5990 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations Day 182 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 586.8 621.6 447.0 696.4 INDIVIDUAL BODY WEIGHTS (g) -520- DuPont-5990 ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 0 Day 7 Male, III - 25 mg/kg/day 646454 646399 646370 646443 646423 646421 646471 646426 646414 646458 646368 646438 646436 646449 646453 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 202.5 222.3 239.8 220.8 224.6 221.3 237.8 209.1 217.5 220.2 226.9 209.0 211.2 194.6 196.0 204.3 224.1 236.9 240.7 225.7 220.3 202.7 216.4 198.9 198.1 220.4 213.1 226.7 217.4 218.7 209.9 234.1 215.6 200.4 198.1 258.9 289.3 295.5 284.5 281.5 274.4 310.2 264.7 273.2 279.3 286.9 255.1 269.5 244.7 229.4 255.8 286.2 297.4 302.2 294.8 282.6 258.5 271.7 251.1 251.1 282.9 266.7 285.1 269.6 277.2 276.5 300.7 272.5 256.9 244.1 Day 14 306.3 359.1 352.6 339.5 339.4 325.4 387.0 321.5 332.4 341.5 337.8 307.3 326.6 286.6 268.9 312.8 348.5 341.2 351.3 355.6 337.3 308.7 331.4 292.9 304.8 344.3 323.7 338.8 318.7 323.5 334.3 375.3 325.6 308.1 280.2 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 352.2 425.3 393.2 389.3 391.3 380.5 443.6 355.6 388.6 399.6 385.9 353.7 379.2 333.8 309.4 354.8 397.7 390.8 377.3 403.4 382.5 350.1 380.2 332.9 355.3 405.3 378.0 392.7 369.0 371.1 382.3 443.4 368.6 356.5 311.5 402.5 477.9 420.5 439.4 426.1 418.3 507.3 391.0 440.8 439.9 417.6 396.7 423.0 387.6 343.9 399.4 441.9 428.4 407.2 452.0 420.9 403.8 422.5 364.8 398.2 456.3 408.6 448.6 410.5 411.5 427.2 498.2 404.4 396.8 331.4 430.4 523.2 439.7 463.3 456.3 444.3 546.8 408.6 479.9 472.4 436.4 426.2 451.3 420.1 359.3 417.0 478.9 459.5 444.8 493.7 457.4 441.1 455.8 394.4 435.5 495.7 445.0 484.8 442.0 444.4 467.7 555.8 435.0 425.2 352.2 450.6 549.2 444.9 480.0 474.2 463.8 560.4 430.3 498.7 486.9 460.3 453.3 479.2 454.8 381.2 440.8 503.5 481.4 474.9 516.9 502.1 469.7 486.8 415.7 460.7 525.2 482.6 514.4 473.8 477.9 498.8 597.6 466.0 452.4 366.7 Day 49 478.0 592.3 465.4 505.3 507.3 490.8 596.2 472.1 512.4 518.3 485.6 471.3 508.7 481.7 403.0 463.3 521.3 505.0 499.1 542.8 530.1 484.5 504.6 439.4 477.3 552.0 504.1 528.8 494.5 502.9 517.6 622.2 500.4 477.4 384.7 ) DuPont-5990 Day 56 500.4 620.9 488.0 529.3 533.0 519.1 628.6 494.5 527.1 540.7 508.3 489.2 537.2 502.5 414.1 480.2 546.8 521.9 525.5 565.9 546.4 512.1 504.6 453.4 500.6 578.6 532.6 560.8 513.4 523.9 541.8 658.4 520.1 494.1 405.6 Company Sanitized. Does not contain TSCA CBI -521- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 63 Day 70 Male, III - 25 mg/kg/day 646454 646399 646370 646443 646423 646421 646471 646426 646414 646458 646368 646438 646436 646449 646453 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 501.2 647.6 505.4 549.8 548.2 538.0 653.2 513.6 551.6 557.4 526.4 505.9 548.7 519.4 426.7 495.0 561.8 536.8 540.7 595.3 559.9 537.9 534.6 471.2 518.5 580.2 557.0 577.8 528.5 548.7 517.6 682.7 534.7 512.7 421.3 528.0 673.3 515.8 579.0 575.4 545.5 671.7 539.8 572.0 579.2 550.5 527.1 562.4 537.4 446.9 507.2 584.5 551.3 561.5 611.5 584.9 563.4 546.0 487.6 540.2 610.5 570.9 601.6 544.9 560.8 547.6 706.8 546.6 528.1 435.8 Day 77 538.0 685.3 534.3 595.0 588.7 556.8 673.4 557.8 588.4 596.2 561.2 535.9 572.6 552.8 458.1 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 548.1 708.5 549.4 606.8 589.1 575.3 692.5 579.4 592.5 608.3 566.0 520.7 582.4 568.5 465.5 545.6 720.4 565.3 619.4 598.7 570.6 713.8 594.3 611.7 610.3 575.8 556.4 590.8 578.1 471.4 585.3 565.8 597.2 588.8 477.6 586.9 582.3 604.8 589.8 489.8 Day 112 601.6 586.7 611.1 603.8 499.5 ) DuPont-5990 Day 119 595.2 589.1 612.3 605.7 508.7 Company Sanitized. Does not contain TSCA CBI -522- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 126 Day 133 Male, III - 25 mg/kg/day 646454 646399 646370 646443 646423 646421 646471 646426 646414 646458 646368 646438 646436 646449 646453 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 607.0 606.4 614.0 623.1 518.0 632.4. 614.6 618.6 639.4 530.2 Day 140 649.1 626.9 619.5 650.5 535.4 INDIVIDUAL BODY WEIGHTS (g) Day 147 Day 154 Day 161 Day 168 664.3 631.9 623.4 654.0 541.1 655.5 635.3 625.8 662.8 548.4 663.0 642.9 636.8 671.6 556.3 673.4 658.4 650.8 680.5 551.7 Day 175 679.4 662.3 647.3 680.9 565.9 ) DuPont-5990 Day 182 692.8 663.7 662.1 693.3 563.7 Company Sanitized. Does not contain TSCA CBI -523- ))) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Day 0 Day 7 Male, V - 100 mg/kg/day 646349 646463 646456 646469 646472 646385 646373 646435 646488 646455 646335 646477 646327 646403 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 200.6 219.5 239.9 222.1 220.7 225.7 230.0 210.7 236.3 216.5 233.6 207.8 215.4 197.3 195.5 225.0 237.7 250.6 227.2 215.5 202.7 216.9 230.7 216.7 228.7 203.2 222.7 217.9 210.5 209.7 196.9 217.4 213.4 219.4 204.7 250.3 272.6 298.2 270.2 255.4 271.2 291.5 262.5 299.6 274.5 281.0 264.3 260.5 242.2 244.0 269.7 286.1 299.9 288.2 269.3 256.9 264.2 281.9 263.9 275.8 247.0 274.4 270.2 264.0 262.8 222.5 263.5 233.0 267.0 246.8 Day 14 303.9 318.7 343.8 322.2 293.3 321.0 355.9 312.9 309.0 326.0 327.5 294.1 304.6 299.8 289.3 320.7 338.7 342.2 342.8 325.3 305.2 309.5 337.5 317.7 321.1 290.7 314.7 320.6 326.8 318.7 265.9 322.2 286.2 312.6 280.8 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 346.3 359.3 393.5 372.2 321.7 366.9 413.8 359.3 364.6 377.5 367.6 327.2 342.3 329.6 331.6 371.6 380.2 374.3 387.7 375.3 350.1 352.3 396.1 364.9 346.1 327.7 345.7 365.3 371.3 364.8 298.5 375.3 325.9 357.2 314.7 377.5 381.7 422.7 404.1 352.7 411.4 470.7 399.8 413.1 417.3 409.0 371.5 365.2 365.9 374.6 419.5 422.7 413.3 440.4 410.8 382.6 384.7 432.3 393.3 378.6 328.7 382.6 402.4 400.0 403.9 333.3 417.7 361.6 384.8 349.3 416.1 398.0 446.7 420.4 378.2 434.7 505.4 431.6 450.6 437.0 438.4 406.8 390.4 382.0 406.4 442.5 451.2 436.0 476.5 436.8 399.3 402.8 467.9 422.1 401.6 362.3 414.7 428.6 432.6 431.9 361.7 454.2 380.2 413.8 372.0 423.6 407.9 457.5 437.1 382.3 450.9 520.9 444.3 459.4 447.8 481.1 440.1 422.0 398.3 435.9 469.0 456.0 458.5 493.8 455.0 430.8 434.9 505.1 443.8 424.7 396.1 448.4 461.9 466.8 458.7 392.7 485.5 407.3 436.3 392.5 Day 49 Day 56 454.9 429.1 480.9 464.8 407.3 468.4 557.6 469.8 483.2 465.8 507.3 460.3 437.9 413.5 461.8 500.2 482.9 479.4 505.0 478.5 457.5 458.5 528.2 461.8 453.5 417.4 472.6 478.2 492.8 477.2 422.4 507.3 422.8 449.1 412.0 486.2 443.7 506.2 479.4 424.2 487.5 573.2 486.2 496.5 484.0 520.9 FD TEST DAY 51 452.2 432.3 470.0 506.0 510.4 494.2 516.7 497.1 469.5 475.1 543.7 477.7 478.8 436.8 487.7 486.7 506.8 486.8 439.3 526.9 442.0 465.9 423.0 Company Sanitized. Does not contain TSCA CBI -524- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) Day 63 Day 70 Male, V - 100 mg/kg/day 646349 646463 646456 646469 646472 646385 646373 646435 646488 646455 646335 646477 646327 646403 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 507.5 449.9 524.6 493.7 440.7 508.6 590.0 506.6 510.3 497.1 536.1 453.8 453.9 492.9 528.8 528.4 502.6 536.2 516.8 477.8 491.3 566.2 494.2 502.1 459.4 494.5 506.9 525.1 496.6 463.9 540.4 459.2 483.7 434.3 524.2 460.4 535.1 510.4 448.1 531.3 613.9 524.1 533.4 514.2 557.9 474.2 469.5 511.6 542.3 549.6 517.0 551.1 535.1 495.4 506.3 588.0 504.3 516.6 481.5 520.9 513.8 541.8 514.4 466.9 554.4 482.0 490.6 446.3 Day 77 527.9 456.4 548.3 510.3 456.1 553.5 629.0 541.9 533.2 523.4 585.1 483.4 484.7 447.4 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 541.9 462.9 546.7 523.4 466.6 563.2 640.6 554.3 550.1 533.7 602.4 499.3 499.5 548.1 469.7 549.1 528.6 470.0 564.6 649.9 553.6 546.2 521.2 599.1 489.4 500.1 601.0 497.4 518.6 624.1 517.6 537.1 456.1 460.1 477.7 493.1 Day 112 647.5 522.2 552.8 500.5 ) DuPont-5990 Day 119 651.4 525.8 554.3 495.9 Company Sanitized. Does not contain TSCA CBI -525- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 126 Day 133 Male, V - 100 mg/kg/day 646349 646463 646456 646469 646472 646385 646373 646435 646488 646455 646335 646477 646327 646403 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 667.5 541.0 558.7 666.6 545.6 566.3 501.3 509.3 INDIVIDUAL BODY WEIGHTS (g) Day 140 Day 147 Day 154 Day 161 Day 168 690.4 563.7 574.1 677.0 565.5 584.9 682.0 576.3 597.2 680.7 581.3 598.8 695.6 593.6 611.3 515.5 516.1 525.2 538.9 543.3 Day 175 707.4 598.4 611.9 543.1 DuPont-5990 Day 182 721.9 602.0 611.9 549.5 Company Sanitized. Does not contain TSCA CBI -526- Company Sanitized. Does not contain TSCA C6I H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 0 Day 7 Male, VII - 500 mg/kg/day 646475 646388 646346 646433 646407 646437 646343 646347 646442 646413 646355 646344 646466 646391 646361 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 646384 646474 646448 646484 646337 646428 646369 646397 646372 204.0 225.5 238.0 215.5 227.8 212.3 229.1 207.4 223.0 215.9 232.3 208.4 214.1 203.4 194.2 206.7 212.6 192.5 237.5 223.7 219.6 202.5 214.0 212.9 221.2 225.5 243.4 207.6 220.7 198.5 218.3 209.2 221.0 216.3 211.8 217.8 221.8 198.4 211.7 208.3 222.1 199.5 189.9 218.0 232.2 220.3 240.0 271.9 237.9 258.7 218.6 247.2 227.6 239.6 237.5 246.3 222.1 236.5 213.9 213.2 213.0 242.1 241.7 267.4 246.3 239.8 224.1 253.1 240.8 239.7 256.1 278.0 225.9 251.5 220.5 238.4 242.3 246.7 242.6 240.9 232.8 240.5 205.1 238.3 240.0 244.0 201.8 214.3 246.9 254.5 Day 14 265.2 311.3 317.6 278.8 313.5 263.0 290.2 273.5 283.2 294.6 296.0 262.9 298.6 267.1 243.3 252.6 288.8 308.2 321.9 300.3 301.7 261.0 296.3 298.3 292.3 318.6 350.0 262.3 313.5 253.5 289.2 304.1 305.9 299.5 282.9 260.2 298.7 262.4 289.4 286.5 289.8 259.5 252.7 300.5 289.3 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 312.9 383.1 362.6 313.4 357.4 293.8 327.8 312.2 325.1 331.3 332.4 300.6 342.5 307.8 279.8 293.9 328.9 352.6 360.4 334.5 345.9 285.7 337.6 348.5 344.5 370.3 410.7 286.4 344.7 300.4 334.9 348.5 353.8 350.3 315.4 280.9 346.5 286.3 329.4 326.0 330.2 312.5 281.1 344.4 322.2 342.8 420.7 390.2 332.6 385.1 328.8 353.8 345.3 353.1 357.9 360.9 323.4 388.7 339.8 310.0 324.9 365.6 397.0 383.5 364.2 377.2 313.3 362.6 385.8 385.5 413.0 453.3 303.3 381.5 331.3 372.7 384.2 371.1 388.7 339.0 297.8 386.5 309.0 355.3 352.0 366.2 349.6 317.8 377.8 343.5 -527- 362.7 356.7 442.2 451.2 407.3 416.0 358.0 359.1 407.3 422.1 343.4 353.5 374.9 381.6 350.7 355.6 366.5 369.1 365.3 352.3 375.1 382.8 331.4 352.3 404.0 419.0 359.6 383.8 327.1 355.4 346.2 370.8 382.7 388.0 419.6 433.5 400.1 426.0 376.8 385.4 406.2 420.5 325.0 344.9 373.3 395.5 402.1 421.9 SE TEST DAY 28 440.3 463.8 485.1 515.8 311.1 321.9 398.7 410.6 358.6 374.8 383.1 406.2 404.2 434.1 398.0 432.7 FD TEST DAY 31 359.4 374.4 316.5 331.9 412.9 449.2 325.3 331.9 366.6 391.5 368.5 387.2 391.7 414.1 375.0 391.6 329.2 350.0 401.0 426.5 353.5 378.9 Day 49 372.2 477.5 449.7 376.3 448.5 379.1 410.8 378.1 378.3 378.4 393.3 374.3 436.9 405.7 386.1 385.6 407.1 449.6 427.7 382.9 435.3 361.0 415.8 428.5 495.7 534.5 338.9 433.5 372.5 426.2 450.5 458.6 386.7 338.8 473.3 342.2 421.4 411.5 435.3 401.8 368.6 442.5 389.6 DuPont-5990 Day 56 401. l 493. 7 464. 1 393. 3 474. 6 398. 8 430. 0 388. 2 395. 2 386. 5 410. 1 389. 1 459. 0 423. 7 401. 7 396. 4 434. 1 465. 7 449. 9 410. 0 462. 9 375. 3 425. 0 460. 7 514. 9 538. 9 349. 7 445. 6 398. 2 443. 4 454. 4 479. 4 397. 6 341. 6 502. 3 370. 7 428. 2 423. 8 452. 6 426. 2 386. 0 453. 4 403. 0 Company Sanitized. Does not contain TSCA CBI ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) Day 63 Day 70 Male, VII - 500 mg/kg/day 646475 646388 646346 646433 646407 646437 646343 646347 646442 646413 646355 646344 646466 646391 646361 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 646384 646474 646448 646484 646337 646428 646369 646397 646372 413.3 513.3 487.3 401.3 490.2 421.6 455.6 409.2 411.5 402.7 420.9 399.0 466.8 425.7 417.2 395.2 447.5 488.8 453.7 427.3 468.0 385.4 444.3 495.7 521.0 562.1 365.6 466.7 413.9 456.1 472.5 486.1 399.4 374.6 520.1 371.2 436.5 445.5 467.4 439.0 398.3 477.6 411.4 422.6 520.3 503.4 408.6 503.2 435.7 459.0 419.0 416.2 403.0 432.7 412.1 475.9 444.4 437.3 399.7 448.2 501.4 464.4 452.2 471.4 402.2 454.4 517.0 541.8 571.1 375.8 480.3 423.5 455.6 473.1 495.0 404.8 384.2 521.6 378.5 445.5 458.5 468.1 440.4 401.8 488.9 428.8 Day 77 439.0 535.8 505.2 415.1 517.1 439.1 473.0 427.8 424.3 411.1 435.6 425.3 466.7 458.5 454.6 393.9 528.5 390.2 459.2 465.4 493.1 456.7 406.7 495.7 398.0 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 444.9 548.9 516.0 413.6 517.8 453.8 486.3 427.7 432.2 423.2 455.5 441.3 483.0 465.1 476.1 468.5 556.2 532.5 422.7 541.5 462.9 486.3 433.0 441.2 434.8 462.8 451.4 469.7 472.1 479.8 497.7 476.1 512.5 479.2 504.3 508.8 501.1 503.6 498.7 528.3 393.5 536.5 377.8 470.2 472.6 506.3 472.6 409.8 497.1 423.9 393.5 555.2 393.3 489.2 478.0 503.7 474.2 422.1 503.7 432.7 -528- 417.8 581.9 422.3 523.6 498.3 528.5 491.5 444.2 524.2 468.7 452.0 615.3 469.0 551.5 513.0 547.6 508.9 465.7 544.6 495.5 Day 112 505.0 522.2 475.4 511.5 542.4 484.2 633.0 494.9 570.1 438.7 563.7 521.0 466.5 555.5 497.3 ) DuPont-5990 Day 119 510.8 524.4 455.6 502.2 564.3 484.1 649.5 497.3 587.3 435.5 574.6 518.2 476.3 560.3 490.1 Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations Day 126 Day 133 Male, VII - 500 mg/kg/day 646475 646388 646346 646433 646407 646437 646343 646347 646442 646413 646355 646344 646466 646391 646361 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 646384 646474 646448 646484 646337 646428 646369 646397 646372 528.4 523.7 523.4 504.9 585.7 546.2 549.0 556.0 518.5 608.0 INDIVIDUAL BODY WEIGHTS (g) Day 140 Day 147 Day 154 Day 161 Day 168 557.8 569.8 576.3 527.2 617.8 571.6 560.9 600.2 531.8 628.7 596.0 582.1 620.9 534.6 634.6 611.7 608.3 631.3 536.1 656.2 622.8 620.7 620.1 537.1 673.5 -529- Day 175 621.2 630.0 637.6 557.8 665.0 DuPont-5990 Day 182 630.0 646.4 645.3 564.5 685.2 H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 0 Day 7 Female, II - 0 mg/kg/day 646592 646560 646676 646665 646612 646538 646659 646649 646617 646537 646642 646530 646588 646597 646507 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 646581 646627 646565 646551 646511 646549 646652 646586 646613 184.7 161.7 196.3 166.9 172.4 188.0 177.8 204.6 171.3 175.7 181.6 171.4 183.4 173.3 178.4 161.3 183.1 160.8 182.2 182.5 166.5 169.6 178.8 172.3 171.8 186.6 152.3 171.6 166.6 188.9 182.3 150.1 167.6 172.3 202.5 159.2 175.4 175.8 179.6 178.1 186.6 185.2 163.1 173.9 167.7 210.4 184.5 218.0 186.4 188.6 212.4 198.1 231.5 197.8 196.6 188.8 180.2 205.1 204.7 192.9 180.7 202.8 180.8 205.4 203.6 184.5 186.0 205.5 190.7 204.2 207.1 177.5 199.2 184.2 205.3 194.9 161.8 196.0 171.7 226.3 185.6 199.5 201.1 206.6 206.8 205.4 205.8 196.2 202.9 190.2 Day 14 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 233.8 190.7 243.6 195.4 206.5 231.3 228.5 260.1 209.0 210.5 219.7 207.8 230.0 216.4 203.8 197.3 230.6 201.9 232.0 228.0 211.6 211.2 232.1 207.6 236.0 226.9 193.0 209.1 190.1 229.0 220.2 175.3 216.0 202.3 258.4 201.4 206.5 216.2 231.7 224.5 235.6 211.1 213.9 220.6 202.4 252.7 206.3 273.8 216.8 218.7 254.0 236.3 283.6 235.1 229.2 216.5 213.1 247.6 251.2 223.6 214.0 268.4 214.8 271.4 248.2 227.9 220.2 249.5 228.2 252.0 244.9 200.8 237.8 209.0 249.4 229.0 193.4 243.8 224.5 276.2 226.8 226.5 231.8 240.0 246.5 271.1 240.7 230.2 235.1 233.0 263.8 220.1 287.3 214.8 233.7 272.1 273.3 301.8 238.2 247.7 223.7 234.2 258.6 263.3 235.4 234.5 256.3 233.5 283.2 267.3 244.4 236.1 274.4 246.9 269.8 260.1 217.3 244.5 228.0 263.3 260.7 207.5 251.9 244.8 305.4 238.7 236.0 250.5 265.4 264.1 285.6 253.5 261.5 259.4 247.8 282.4 220.4 302.1 221.0 259.1 286.6 287.9 327.0 265.2 251.6 231.1 247.4 ' 276.6 280.4 238.6 239.2 292.1 239.8 289.0 280.7 257.9 242.6 282.6 255.9 281.8 269.5 218.6 256.8 234.8 289.7 276.6 218.4 273.7 244.5 320.2 250.6 248.4 254.8 286.9 279.8 292.9 272.5 280.2 274.7 257.1 285.3 225.3 299.0 236.2 268.9 299.9 289.9 329.3 267.6 266.1 237.3 266.2 282.7 290.6 247.2 260.9 298.7 256.2 317.8 299.8 268.0 263.5 298.8 266.3 292.5 283.2 234.9 257.3 247.2 292.4 286.4 220.8 280.4 271.1 329.0 259.3 264.6 269.3 296.2 296.5 306.8 290.0 304.3 283.9 272.6 Day 49 299.9 235.5 327.3 241.6 280.0 313.1 305.7 344.8 286.8 270.2 237.8 281.8 298.4 313.3 259.4 268.1 315.3 266.8 335.1 311.3 283.7 265.2 309.7 277.9 293.8 285.8 238.7 266.4 257.3 301.0 299.8 234.0 288.7 269.2 349.0 266.1 260.9 269.6 311.9 304.0 315.8 308.3 304.0 292.2 282.2 DuPont-5990 Day 56 310. 3 247. 5 325. 4 248. 8 270. 4 321. 5 319. 5 356. 3 293. 0 277. 0 246. 6 279. 2 289. 9 311. 6 266. 2 277. 6 317. 9 268. 5 338. 5 321. 4 283. 7 278. 4 311. 9 286. 4 307. 5 288. 8 243. 1 272. 4 261. 0 307. 2 309. 1 243. 1 286. 7 270. 9 350. 3 275. 7 275. 5 273. 0 330. 1 313. 5 308. 8 321. 6 314. 4 287. 4 285. 9 Company Sanitized. Does not contain TSCA CBI -530- Company Sanitized. Does not contain TSCA CBI )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations___________ Day 63 Day 70 Female, II - 0 mg/kg/day 646592 646560 646676 646665 646612 646538 646659 646649 646617 646537 646642 646530 646588 646597 646507 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 646581 646627 646565 646551 646511 646549 646652 646586 646613 311.2 248.1 329.5 257.6 286.2 324.2 321.3 356.1 292.3 277.2 255.2 273.9 297.6 329.0 265.8 276.4 316.2 272.7 342.8 332.3 292.2 283.2 305.7 290.3 311.1 289.8 244.1 278.7 274.4 316.6 316.1 247.6 294.2 287.8 349.4 279.6 281.0 281.3 341.2 317.3 305.7 320.3 319.5 284.2 294.5 322.3 250.4 338.4 265.1 296.1 333.1 328.5 361.2 306.4 294.0 264.5 297.2 309.7 333.2 278.3 283.3 336.5 282.3 354.5 343.6 298.7 286.0 306.4 293.9 307.0 303.8 251.7 287.0 280.0 323.5 318.9 244.4 298.0 296.9 346.3 280.2 293.8 294.9 344.4 325.5 319.1 340.3 327.2 291.3 301.3 Day 77 322.7 255.7 340.4 272.9 295.2 341.9 333.5 368.7 316.2 290.7 265.6 283.0 308.4 337.1 285.0 287.1 293.9 298.9 343.2 334.8 330.4 364.3 332.5 297.9 299.1 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 328.6 256.3 347.8 271.8 291.5 341.9 339.7 371.7 311.4 297.5 278.7 301.4 320.8 341.0 288.2 345.5 254.6 350.6 278.0 298.0 339.8 339.9 373.5 324.5 305.1 AK TEST DAY 89 306.2 323.4 340.8 277.6 303.0 332.5 354.6 309.9 309.0 332.0 355.3 294.4 285.8 303.1 299.5 363.4 334.5 334.5 359.4 339.3 299.6 299.1 280.0 303.4 298.0 366.3 332.4 334.9 363.5 340.9 296.8 306.6 -531- 291.1 306.8 301.6 369.6 334.1 336.5 377.2 342.3 297.9 314.5 293.7 320.4 309.3 363.1 336.3 324.9 386.2 354.5 302.9 321.1 Day 112 312.9 347.5 370.6 295.8 298.8 328.1 328.3 387.8 348.8 338.3 396.1 373.2 324.1 322.9 I DuPont-5990 Day 119 318.5 343.8 377.5 300.1 301.4 315.8 325.7 393.2 356.4 329.6 397.2 374.4 316.6 326.9 Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 126 Day 133 Female, II - 0 mg/kg/day 646592 646560 646676 646665 646612 646538 646659 646649 646617 646537 646642 646530 646588 646597 646507 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 646581 646627 646565 646551 646511 646549 646652 646586 646613 324.9 351.4 386.0 294.8 319.8 341.9 392.6 302.2 Day 140 336.7 340.3 393.4 288.2 INDIVIDUAL BODY WEIGHTS (g) Day 147 Day 154 Day 161 Day 168 332.7 348.9 391.4 312.2 336.7 353.9 394.0 297.9 340.1 358.4 401.9 310.0 336.9 344.5 412.3 312.4 -532- Day 175 344.2 345.5 415.4 325.8 DuPont-5990 Day 182 350.7 347.4 418.7 307.2 H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 0 Day 7 Female, IV - 25 mg/kg/day 646522 646660 646502 646595 646567 646673 646635 646664 646621 646576 646625 646568 646626 646531 646636 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 165.4 151.1 154.2 161.7 192.3 173.4 173.7 177.6 181.0 185.9 170.5 186.3 162.3 192.6 172.7 183.3 173.3 201.4 173.1 181.9 182.0 160.2 208.0 171.5 178.6 188.1 162.8 176.0 189.4 185.6 162.3 173.8 178.8 183.3 184.9 190.1 167.6 171.0 179.2 204.0 183.8 192.9 199.4 212.3 213.6 186.4 212.0 177.3 200.7 183.1 196.9 198.4 226.6 203.9 195.6 196.7 179.6 233.5 190.2 192.3 212.6 184.3 200.9 209.3 197.9 173.6 197.3 204.8 206.7 198.7 Day 14 210.5 188.7 186.1 191.3 209.0 207.0 215.1 214.9 234.5 233.1 194.9 232.0 185.2 211.8 193.2 227.4 216.9 245.2 217.9 224.5 215.0 201.9 262.7 205.7 205.8 234.5 211.3 217.3 230.3 227.1 194.5 212.1 224.4 235.0 211.6 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 224.0 206.1 198.9 208.6 235.7 222.8 222.4 232.2 247.3 261.4 219.7 255.5 198.9 233.8 206.3 253.9 239.7 265.6 249.6 234.7 221.6 209.1 288.0 231.3 233.6 249.2 224.0 240.2 248.2 242.3 215.3 233.9 244.3 261.4 233.3 239.3 220.9 204.7 232.9 250.0 231.3 247.9 248.8 270.9 285.5 238.0 276.1 205.0 250.5 224.7 262.3 262.6 278.9 264.1 259.6 245.7 234.2 306.0 251.3 249.4 282.3 246.9 253.5 266.8 259.1 220.5 251.7 263.3 290.5 260.5 259.0 227.1 215.6 248.1 266.7 243.2 257.2 263.6 284.4 293.9 251.9 294.8 206.9 265.5 235.6 279.5 282.5 296.6 273.9 269.2 255.3 250.7 322.6 266.7 264.7 287.5 257.6 257.8 288.7 271.5 246.9 261.1 273.2 300.4 265.3 252.6 228.6 225.9 239.9 269.8 248.6 263.8 270.4 301.0 296.0 265.1 308.7 217.4 269.4 241.4 289.6 294.7 312.7 288.8 284.8 270.0 260.3 329.2 276.5 270.7 296.6 268.6 266.6 294.5 274.9 257.8 267.8 293.3 303.6 268.3 Day 49 266.4 240.9 234.2 264.0 288.0 257.4 276.9 285.0 310.2 303.6 273.5 324.8 222.7 280.3 257.4 314.4 301.5 335.6 286.6 302.9 280.6 264.5 349.1 286.9 279.0 304.9 271.7 269.1 304.0 284.9 268.9 269.0 291.5 319.8 283.5 DuPont-5990 Day 56 274. 3 248. 7 247. 7 266. 7 293. 7 251. 4 287. 3 293. 9 321. 5 322. 4 285. 3 333. 0 225. 5 286. 3 262. 2 306. 7 306. 1 344. 9 300. 7 305. 2 287. 0 260. 6 351. 5 290. 7 279. 4 313. 4 284. 2 283. 5 312. 2 281. 7 275. 5 272. 5 299. 3 329. 7 298. 7 Company Sanitized. Does not contain TSCA CBI -533- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) Day 63 Day 70 Female, IV - 25 mg/kg/day 646522 646660 646502 646595 646567 646673 646635 646664 646621 646576 646625 646568 646626 646531 646636 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 276.9 247.6 241.7 266.6 301.7 255.1 291.5 286.1 331.9 331.9 289.8 339.4 225.6 288.4 268.5 310.0 309.7 349.0 305.8 313.5 288.5 254.9 361.9 296.4 279.7 313.5 285.5 281.7 313.0 284.0 283.1 274.3 306.0 332.5 299.3 293.4 255.4 245.8 273.1 322.0 257.9 300.3 302.8 346.2 336.3 296.2 353.4 236.8 286.2 271.9 307.7 318.7 350.9 302.8 321.1 287.7 268.8 366.3 298.2 291.4 310.3 285.8 297.3 319.9 293.8 290.1 277.7 309.6 329.9 302.5 Day 77 289.4 262.7 249.6 280.7 332.3 266.5 304.3 306.8 339.5 354.3 295.4 365.1 232.6 290.7 274.2 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 293.0 265.5 247.3 284.0 338.0 265.3 305.1 311.9 352.0 357.7 303.3 367.0 244.4 299.4 287.6 295.7 265.5 260.1 275.5 332.4 268.2 307.0 322.3 364.8 359.9 309.2 372.1 246.8 308.8 294.6 311.3 377.8 250.3 313.7 291.3 320.6 390.6 218.8 313.1 305.1 Day 112 326.0 394.2 249.8 321.3 313.7 ) DuPont-5990 Day 119 331.3 407.9 255.1 319.6 318.3 Company Sanitized. Does not contain TSCA CBI -534- )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations___________ Day 126 Day 133 Female, IV - 25 mg/kg/day 646522 646660 646502 646595 646567 646673 646635 646664 646621 646576 646625 646568 646626 646531 646636 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 341.1 410.5 254.7 323.6 324.0 340.4. 415.9 260.7 319.1 320.6 Day 140 340.8 422.8 258.3 319.1 335.8 INDIVIDUAL BODY WEIGHTS (g) Day 147 Day 154 Day 161 Day 168 350.5 425.6 254.3 315.7 326.2 344.2 429.6 262.0 320.8 322.1 352.1 429.2 256.3 328.9 340.0 350.9 437.3 259.6 338.3 342.9 Day 175 351.1 435.8 259.6 340.7 343.2 ) DuPont-5990 Day 182 353.7 444.1 263.1 343.8 345.0 Company Sanitized. Does not contain TSCA CBI - 535- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 0 Day 7 Female, VI - 100 mg/kg/day 646608 646556 646629 646510 646578 646505 646534 646624 646501 646633 646656 646630 646634 646533 646632 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 165.6 178.7 179.5 181.3 185.8 175.0 177.9 173.2 176.3 182.2 163.5 197.6 164.6 170.6 185.4 157.3 206.1 186.4 181.2 189.3 167.2 175.9 187.4 185.1 173.7 179.2 168.2 173.8 187.5 176.2 159.2 163.7 173.9 192.3 166.1 184.4 193.9 196.1 199.3 203.5 194.3 199.3 192.1 190.0 202.2 191.2, 221.5 181.4 184.8 199.4 181.7 226.1 200.5 189.4 204.3 175.5 196.2 189.5 201.0 190.8 186.7 188.7 187.4 207.7 192.9 168.9 179.4 193.2 202.5 190.1 Day 14 207.5 210.1 214.2 231.2 226.8 218.3 222.2 213.1 207.4 221.9 212.8 246.2 187.3 201.6 222.0 198.1 249.7 214.3 207.3 233.1 200.4 210.6 207.9 222.8 208.1 212.2 210.3 199.6 234.1 212.6 180.7 202.5 214.2 220.8 215.0 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 226.0 235.4 232.6 245.1 248.2 237.5 241.5 236.5 235.3 236.2 237.9 269.8 213.0 217.1 247.8 217.4 272.2 243.4 222.9 247.4 209.6 229.3 231.0 249.0 237.1 233.9 230.5 217.9 249.4 235.3 191.6 223.6 241.9 235.4 233.9 239.4 249.7 247.7 276.9 252.9 254.7 256.3 247.9 250.8 256.7 254.0 295.5 222.7 236.1 250.1 229.0 291.9 246.9 243.8 250.5 218.7 239.5 237.6 253.2 263.1 253.4 250.0 235.8 274.0 256.1 209.4 240.4 263.2 249.4 251.8 242.1 267.8 258.3 284.1 261.6 258.1 265.0 258.0 260.2 271.5 247.1 313.3 228.5 244.5 256.0 250.9 297.2 265.6 247.2 273.0 236.2 251.5 247.5 262.0 267.8 260.5 268.8 247.2 248.1 266.9 212.2 249.3 269.6 257.0 265.9 248.6 280.9 259.3 292.9 276.6 283.1 277.9 269.8 268.1 273.9 274.2 332.0 232.8 248.4 281.0 258.1 307.9 256.9 260.4 282.2 240.9 264.6 254.8 289.2 278.3 273.8 281.6 257.3 286.3 281.6 223.8 266.8 274.7 266.2 273.0 Day 49 261.6 302.5 273.2 308.7 288.9 302.0 292.2 276.0 282.1 290.5 286.0 351.6 250.3 257.9 279.6 269.3 327.2 302.9 266.4 292.7 255.8 271.9 259.9 300.6 286.8 281.9 292.4 269.5 296.2 285.6 232.2 276.9 283.5 275.0 288.2 ) DuPont-5990 Day 56 257.8 314.9 281.4 320.6 285.4 315.8 288.2 280.3 293.2 301.2 294.9 358.7 252.1 270.6 288.0 277.4 333.1 301.0 273.8 296.2 261.6 283.2 266.2 300.9 290.6 282.9 294.4 267.2 301.3 282.0 227.3 280.3 286.7 285.3 291.4 Company Sanitized. Does not contain TSCA CBI -536- ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 63 Day 70 Female, VI - 100 mg/kg/day 646608 646556 646629 646510 646578 646505 646534 646624 646501 646633 646656 646630 646634 646533 646632 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 262.3 323.1 282.8 327.2 292.8 329.4 293.5 285.2 297.4 304.3 287.7 368.7 249.1 274.1 286.4 285.0 342.1 308.0 276.1 305.6 264.0 294.6 278.6 310.4 280.8 293.5 297.2 271.9 316.2 296.1 238.5 281.9 295.7 288.2 310.3 272.6 329.0 283.5 328.2 303.5 336.7 305.8 305.2 300.0 306.5 296.1 371.1 266.5 273.1 300.7 296.2 349.2 306.2 276.4 297.9 268.0 295.8 284.4 318.7 300.1 296.2 304.1 270.8 319.0 303.6 248.8 286.1 297.4 287.5 306.5 Day 77 270.8 339.8 296.3 325.8 299.5 344.5 307.1 304.7 309.5 312.1 292.8 377.3 253.5 275.1 304.2 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 278.0 348.6 296.1 337.7 310.8 357.6 310.6 315.2 322.0 321.3 306.2 384.0 260.9 278.2 312.3 277.5 352.5 291.0 332.7 316.8 357.9 314.5 312.7 320.2 319.2 311.5 389.0 263.1 289.2 312.3 325.6 390.4 267.9 286.4 311.6 327.4 401.5 274.6 298.7 317.2 Day 112 347.3 398.5 286.0 315.0 314.4 ) DuPont-5990 Day 119 348.0 398.5 275.7 312.1 301.7 Company Sanitized. Does not contain TSCA CBI -537- ) H-24768: Subchionic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 126 Day 133 Female, VI - 100 mg/kg/day 646608 646556 646629 646510 646578 646505 646534 646624 646501 646633 646656 646630 646634 646533 646632 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 355.6 403.8 293.2 311.4 315.1 363.4 407.7 296.2 308.7 313.2 Day 140 369.2 421.3 316.6 308.1 306.8 INDIVIDUAL BODY WEIGHTS (g) Day 147 Day 154 Day 161 Day 168 372.5 413.9 308.7 313.0 317.3 376.0 405.5 299.1 314.8 315.3 376.2 416.5 298.9 321.0 315.8 386.7 415.7 302.9 312.9 312.6 Day 175 391.5 417.0 291.5 313.7 314.6 ) DuPont-5990 Day 182 403.6 425.5 310.6 314.0 322.6 Company Sanitized. Does not contain TSCA CBI -538- Company Sanitized. Does not contain TSCA CBI )) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations___________ Day 0 Day 7 Female, VIII - 500 mg/kg/day 646657 646610 646536 646593 646509 646669 646614 646609 646577 646535 646667 646523 646528 646601 646620 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 646548 646508 646650 646637 646545 646618 646506 646542 646599 191.6 165.0 199.3 174.9 172.4 184.1 165.9 208.5 164.7 192.1 180.3 153.6 185.4 183.5 187.3 151.9 171.3 174.8 178.1 183.2 163.7 189.5 171.4 190.3 163.8 196.7 163.6 175.6 171.1 177.4 178.1 156.2 160.9 176.3 196.6 178.5 181.3 183.5 167.3 180.3 167.8 174.6 169.0 180.9 166.7 205.8 177.9 235.1 162.9 187.8 170.6 185.5 201.2 177.0 184.1 197.9, 171.3 190.2 196.0 186.8 159.7 183.9 201.7 193.8 203.2 173.3 193.2 179.3 191.6 167.0 204.1 171.1 176.8 174.2 186.1 180.3 166.2 153.6 185.2 196.1 178.1 168.2 194.0 192.6 184.3 172.2 188.5 179.9 206.3 190.0 Day 14 232.7 195.4 259.2 192.5 218.3 202.4 212.5 225.2 189.0 216.6 215.5 179.1 215.3 214.5 202.6 178.9 201.5 228.8 218.6 233.0 208.6 218.8 201.7 214.7 187.8 226.7 191.0 203.1 199.1 208.3 208.1 191.1 187.2 220.1 210.2 205.0 208.3 234.4 214.3 215.5 202.5 211.2 195.4 234.0 216.0 INDIVIDUAL BODY WEIGHTS (g) Day 21 Day 28 Day 35 Day 42 254.8 218.8 279.0 212.1 250.5 228.6 227.7 248.7 210.7 233.1 235.9 195.5 238.1 244.0 211.4 193.8 221.2 246.1 241.5 252.0 232.6 237.0 225.0 238.4 194.4 252.4 215.4 210.0 212.2 226.6 230.7 210.3 205.8 234.7 238.2 227.5 232.2 241.9 230.3 238.6 223.6 233.5 213.0 249.6 229.7 268.5 232.7 285.4 215.4 250.4 236.8 258.2 272.0 219.4 255.9 245.5 208.5 256.3 261.2 232.0 204.1 245.1 263.8 266.6 273.2 254.7 247.6 237.4 256.4 205.9 262.9 228.4 234.0 226.8 255.6 250.8 227.9 221.6 253.2 255.3 245.4 247.0 265.6 253.2 260.1 241.7 261.0 232.8 273.4 254.5 -539- 279.1 243.9 297.3 218.4 260.8 239.7 255.7 291.2 225.9 260.9 256.7 214.3 260.9 269.8 241.4 219.9 250.4 266.1 284.1 295.3 269.8 252.8 253.8 273.5 218.1 278.1 242.5 245.2 242.4 258.7 260.8 239.4 230.2 258.4 251.0 252.8 248.9 274.7 246.8 264.8 246.1 267.9 240.1 283.3 257.2 289.5 248.9 301.8 228.8 276.2 245.7 267.3 292.2 232.5 269.9 269.2 223.2 275.7 279.5 255.8 227.6 267.1 285.3 291.0 290.6 283.7 253.2 265.1 279.4 224.5 279.3 246.7 256.9 250.3 274.2 271.9 252.6 239.8 274.4 277.6 264.2 254.3 293.6 269.5 276.3 259.9 275.3 249.1 295.8 264.2 Day 49 310.0 263.2 316.9 242.4 303.1 261.1 277.8 309.4 239.9 277.2 275.5 231.7 288.4 290.9 255.3 228.7 266.7 292.9 318.6 318.8 283.8 268.7 271.7 292.6 228.4 287.1 258.8 264.6 256.9 283.9 270.9 256.9 248.0 283.0 277.9 273.2 263.8 300.2 273.3 280.0 267.4 282.1 259.4 299.8 277.5 ) DuPont-5990 Day 56 312.7 269.4 319.4 242.4 291.4 264.8 293.2 308.5 246.9 291.1 277.6 235.4 291.0 295.6 266.5 237.8 280.3 292.0 322.8 321.4 300.1 277.9 274.7 310.1 236.6 289.6 259.2 269.8 267.6 283.8 286.7 255.5 258.6 285.2 287.3 282.8 264.4 312.1 276.9 288.6 272.7 295.6 262.6 305.9 268.7 Company Sanitized. Does not contain TSCA CBI ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) Day 63 Day 70 Female, VIII - 500 mg/kg/day 646657 646610 646536 646593 646509 646669 646614 646609 646577 646535 646667 646523 646528 646601 646620 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 646548 646508 646650 646637 646545 646618 646506 646542 646599 319.9 271.1 327.7 240.1 302.1 263.7 300.9 314.0 254.4 296.2 281.9 244.4 296.1 305.5 282.2 235.9 283.9 296.3 318.7 323.5 308.5 269.7 282.9 308.7 243.7 289.1 270.3 278.5 271.2 283.2 294.3 264.4 259.1 294.3 283.3 281.2 266.3 314.6 288.1 291.2 283.5 297.4 264.0 312.9 277.2 318.9 274.6 323.8 243.5 307.2 277.1 293.6 322.5 254.7 293.3 288.0 246.2 309.7 310.5 281.2 241.7 293.4 297.3 327.9 339.1 299.9 276.0 288.7 318.3 244.7 293.1 266.8 276.4 276.6 291.3 292.1 273.4 262.6 289.9 292.3 286.2 278.4 324.1 289.3 302.4 276.2 301.9 278.0 320.2 271.3 Day 77 325.9 287.6 329.3 259.9 315.9 281.7 293.1 331.4 256.7 297.7 288.1 252.9 305.3 303.1 280.5 291.3 276.4 323.9 289.6 311.6 285.4 309.4 277.2 326.4 277.4 INDIVIDUAL BODY WEIGHTS (g) Day 84 Day 91 Day 98 Day 105 331.2 295.3 328.1 264.5 313.8 274.2 303.8 338.1 259.8 298.2 297.4 264.1 305.5 308.7 289.0 320.6 298.1 320.3 270.2 312.3 283.4 302.3 344.1 261.4 305.7 302.1 264.8 307.7 317.1 287.6 293.6 267.0 310.2 321.9 301.6 303.5 270.4 259.7 323.8 312.1 294.7 287.7 328.7 306.0 312.2 286.4 309.3 285.0 331.8 285.2 296.8 301.2 324.2 296.7 311.4 285.5 301.9 278.8 320.4 285.3 287.9 297.5 321.2 308.0 326.6 275.5 295.4 277.3 320.3 283.1 297.1 295.4 325.7 314.7 314.3 278:5 304.4 275.3 321.8 283.1 -540- Day 112 301.3 271.8 304.2 338.7 317.0 304.1 327.0 337.2 320.7 331.6 293.0 314.2 278.4 347.8 293.0 ) DuPont-5990 Day 119 302.8 262.8 242.1 332.3 315.5 305.3 326.2 328.8 334.3 314.4 299.3 299.1 276.7 348.1 281.2 ) H90--2D47ay68G: aSvuabgcehSrotunidcyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 INDIVIDUAL BODY WEIGHTS (g) Day 126 Day 133 Female, VIII - 500 mg/kg/day 646657 646610 646536 646593 646509 646669 646614 646609 646577 646535 646667 646523 646528 646601 646620 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 646548 646508 646650 646637 646545 646618 646506 646542 646599 308.2 263.8 317.8 339.5 322.9 304.1 261.4 328.8. 351.2 326.2 Day 140 303.6 263.2 343.8 364.1 329.5 Day 147 312.0 272.8 334.8 360.9 329.0 Day 154 307.0 269.4 347.0 360.6 331.0 Day 161 319.0 268.1 359.2 365.3 338.3 Day 168 322.0 263.9 348.9 373.0 337.9 Day 175 322.2 261.7 354.3 372.1 330.0 Day 182 323.8 265.9 380.4 373.5 334.5 Company Sanitized. Does not contain TSCA CBI -541- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX D INDIVIDUAL FOOD CONSUMPTION -542Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL FOOD CONSUMPTION Critical Dates EXPLANATORY NOTES Day 70 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals. Food consumption data collection for rats designated for reproduction evaluation (pregnant females during gestation and Fi pups after weaning) are reported in the Reproduction Toxicology section. Day 9i Last day of food consumption data collection for male and female rats designated for the 91-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designated for 91-day exposure period were sacrificed. Day 119 Last day of food consumption data collection for rats designated for the one- month recovery period. Last day of food consumption data collection for rats designated for the 3-month recovery period. Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. Footnotes # Due to error, an inaccurate food consumption value was recorded. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis -543Company Sanitized. Does not contain TSCA CBI H-24768: Subchionic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Day 7 Day 14 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 24.5 23.1 28.0 29.5 28.7 26.1 29.2 29.5 24.6 24.9 27.7 24.6 20.9 22.4 24.2 25.9 25.8 31.3 27.4 28.1 26.7 25.0 28.3 28.8 26.6 33.6 26.1 28.1 24.0 27.5 24.0 26.8 25.3 27.0 25.3 26.0 25.9 11.5 31.8 24.5 25.5 27.2 27.4 26.7 25.2 27.0 24.2 30.3 31.5 31.3 27.0 29.7 35.3 25.2 27.8 28.9 26.0 19.3 ' 23.6 26.7 27.0 26.4 32.5 29.1 30.0 28.7 _a 30.0 28.9 28.7 35.9 28.1 29.5 26.0 30.3 25.6 25.9 28.1 27.8 23.9 26.0 26.4 21.6 34.0 26.3 27.9 28.5 30.2 25.9 28.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 29.0 23.4 33.0 31.4 30.0 28.0 31.9 34.7 26.4 30.3 28.6 30.3 19.5 25.6 26.8 27.3 27.4 33.6 31.3 31.3 31.2 26.3 33.3 31.4 31.0 40.1 27.7 29.0 24.6 30.2 28.3 27.3 28.3 28.9 22.7 29.1 28.3 22.5 37.7 27.7 30.8 30.2 30.6 29.1 31.4 31.4 27.0 34.6 34.0 29.9 28.6 35.3 38.7 28.8 32.2 30.3 30.2 21.3 27.9 28.4 27.7 27.0 36.4 33.7 33.4 33.6 30.7 36.3 32.7 32.1 38.1 30.0 29.2 25.0 32.8 27.8 29.0 29.4 30.9 24.0 28.5 32.0 24.1 36.2 29.5 34.1 29.8 30.4 30.5 32.9 30.3 27.6 33.1 35.5 29.7 27.2 34.2 37.9 29.2 35.3 29.7 30.4 21.3 28.3 27.2 26.4 27.6 34.4 32.1 35.5 35.6 28.8 35.2 31.6 35.9 36.4 30.8 30.3 25.4 31.8 27.2 27.4 29.0 31.3 24.8 27.9 32.1 22.8 37.2 28.1 29.4 31.0 30.4 29.3 34.7 27.3 26.2 30.7 31.8 27.7 24.9 31.6 37.3 28.1 37.4 30.2 32.5 21.3 30.0 28.8 31.5 30.2 34.1 33.8 35.1 35.0 30.3 34.7 33.1 35.3 38.2 33.4 32.5 26.6 32.7 27.1 31.0 31.9 33.1 25.9 29.2 30.0 23.6 38.7 29.4 34.4 31.1 30.2 31.5 30.9 28.8 27.8 34.7 36.9 31.6 26.1 35.2 39.6 27.4 36.5 28.8 32.4 21.1 32.7 30.4 32.8 29.1 33.4 32.7 33.9 32.6 29.3 35.4 33.1 35.0 37.6 31.6 31.5 26.5 31.9 29.4 30.9 32.5 31.7 26.6 28.0 31.5 24.0 38.6 29.4 31.8 30.8 29.6 30.0 33.7 29.0 29.0 36.5 38.5 33.3 31.1 33.6 40.3 28.3 32.7 26.8 29.8 20.3 32.4 27.9 34.5 29.0 32.6 34.4 38.1 33.1 23.7 37.1 33.2 34.5 37.4 32.8 29.4 26.4 34.0 27.5 32.4 31.7 32.4 27.2 29.2 32.2 23.1 39.1 30.3 36.8 31.0 33.0 31.4 34.8 Day 63 Day 70 30.1 27.3 35.7 34.1 31.5 29.3 27. 7 25. 6 32. 3 31. 0 32. 3 26. 7 35.3 33. 5 39.9 37. 0 26.2 26. 9 SE TEST DAY 57 24.7 28.7 25. 3 28. 5 19.8 30.1 29.8 32.6 24.2 18. 3 29. 5 28. 7 30. 2 26. 2 31.6 28. 4 34.1 31. 9 37.0 35. 3 32.2 32. 7 29.1 36.2 28. 2 32. 7 34.4 32. 5 35.4 37.5 31.2 28.8 33. 1 36. 1 31. 2 28. 7 25.1 31.7 26.4 33.6 31.5 25. 5 33. 8 27. 4 30. 1 30. 0 32.4 27.1 32. 4 25. 8 27.1 26. 7 31.4 31. 1 22.2 21. 1 38.1 29.2 34. 2 29. 3 35.2 32. 9 31.7 29. 3 30.8 33.2 34.8 26. 9 27. 7 32. 6 Company Sanitized. Does not contain TSCA CBI -544- Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 77 Day 84 Male, I- 0 mg/kg/day 646482 646427 646360 646489 646379 646485 646420 646374 646367 646457 646325 646396 646495 646468 646490 646440 646424 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 646461 646480 646383 646445 646358 646425 646408 646459 646460 646416 646371 646411 646398 646487 646446 646432 646494 646492 25.8 25.6 31.1 31.3 32.5 26.6 30.5 34.3 28.4 26.0 29.9 17.1 29.1 25.8 27.4 30.0 20.4 35.9 26.7 34.3 29.4 27.7 28.9 30.8 28.0 27.3 32.7 29.6 31.7 28.1 29.9 38.8 28.5 25.8 29.7 17.3 29.2 24.6 28.2 28.7 23.1 34.6 27.0 28.5 28.7 28.2 29.7 33.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 28.0 26.0 30.8 32.8 31.8 29.1 31.2 39.6 28.6 24.1 23.8 17.9 28.1 26.6 24.2 18.4 31.5 21.8 26.9 17.4 23.9 24.7 27.4 17.8 27.7 24.7 27.6 17.7 30.1 25.4 27.1 30.3 23.8 34.2 27.8 28.9 28.9 29.4 28.8 34.2 25.7 27.6 31.4 22.6 36.3 28.3 30.7 31.9 30.8 31.5 26.8 28.5 31.8 23.0 36.6 29.1 32.5 32.1 30.6 31.6 24.6 27.2 27.6 22.5 36.0 28.9 31.4 29.4 28.5 29.2 -545- 25.3 27.8 31.6 22.9 35.4 28.3 30.4 29.4 27.3 29.8 DuPont-5990 H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Day 7 Day 14 Male, III - 25 mg/kg/day 646454 646399 646370 646443 646423 646421 646471 646426 646414 646458 646368 646438 646436 646449 646453 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 25.1 29.2 26.4 27.9 26.4 26.0 31.5 25.8 24.5 28.2 25.6 26.2 26.2 22.8 20.0 23.8 30.5 33.3 25.9 29.4 29.1 23.1 26.0 26.4 23.3 24.3 27.7 17.3 27.9 22.6 31.0 37.9 24.2 26.1 22.9 . 25.5 33.3 28.9 29.3 26.0 28.2 36.2 28.4 27.7 30.8 28.1 28.0 28.1 24.9 21.8 26.5 32.9 31.1 28.1 29.6 30.0 28.6 29.0 24.6 25.3 30.8 28.3 27.8 25.5 27.2 29.5 32.3 28.9 26.4 23.3 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 27.1 36.2 29.2 31.8 31.2 31.1 38.5 28.7 30.4 32.2 29.4 31.2 30.2 27.3 23.7 27.4 33.3 33.2 26.4 32.0 32.2 28.5 29.3 25.4 28.2 33.3 30.6 30.8 26.7 28.4 29.7 35.1 29.5 28.0 23.9 30.1 36.9 28.6 34.0 30.5 33.5 41.0 29.7 33.8 34.7 30.8 33.2 32.9 32.0 25.9 30.8 34.7 35.1 28.3 34.4 34.0 31.2 31.2 26.0 31.2 35.9 31.1 33.4 28.6 30.3 30.2 38.8 31.3 30.0 23.1 30.1 37.2 28.2 31.7 29.8 33.1 40.6 28.9 32.8 31.9 30.4 32.1 31.5 32.1 25.2 27.8 35.2 35.0 31.3 34.4 33.7 32.5 31.2 26.0 29.8 36.0 33.8 33.3 28.2 30.9 32.3 40.0 32.8 29.0 24.1 28.1 34.7 26.9 31.5 27.9 30.3 35.3 28.2 30.3 29.4 30.0 32.2 32.7 30.3 25.1 28.9 32.6 34.7 31.7 34.9 37.8 35.8 33.3 26.0 29.9 37.1 35.3 32.8 28.8 32.2 32.7 41.0 32.7 31.8 25.2 30.0 38.3 27.7 34.4 29.9 32.2 40.3 33.8 30.4 33.5 29.4 30.8 32.7 30.7 23.4 27.3 32.0 32.6 32.0 35.2 35.2 32.8 30.7 26.6 28.0 35.1 32.6 32.1 29.8 32.4 30.4 38.5 32.7 29.9 24.6 31.3 38.5 28.8 34.0 31.1 32.0 39.5 33.4 29.3 32.0 30.4 31.1 34.4 30.8 22.7 28.1 33.0 32.3 33.6 35.3 36.7 34.3 30.5 26.3 30.1 35.7 33.2 33.9 28.5 33.3 31.2 39.7 32.8 29.4 25.7 Day 63 24.3 37.9 28.3 34.0 31.4 32.0 40.2 30.6 31.0 32.5 28.8 31.2 32.0 29.5 22.6 27.2 32.3 32.9 31.9 36.4 27.9 34.3 29.5 25.8 29.8 30.1 33.6 35.7 29.1 33.3 20.5 40.6 31.7 29.1 24.8 Day 70 29.1 36.3 26.5 34.5 31.0 30.5 38.6 30.7 30.2 32.7 31.3 31.9 30.5 29.1 23.1 25.8 34.2 34.4 32.1 35.4 36.5 36.0 30.5 25.6 29.4 33.2 32.2 33.6 27.6 31.0 29.9 41.2 31.4 28.2 24.1 Company Sanitized. Does not contain TSCA o 00 Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) Day 77 Day 84 Day 91 Male, III - 25 mg/kg/day 646454 646399 646370 646443 646423 646421 646471 646426 646414 646458 646368 646438 646436 646449 646453 646378 646483 646363 646334 646493 646404 646415 646410 646340 646354 646467 646381 646342 646450 646326 646377 646478 646350 646333 646486 26.1 33.9 28.6 33.8 31.9 30.7 32.5 29.8 31.2 16.9 30.6 30.2 29.7 28.2 23.1 28.8 38.2 30.1 33.9 27.3 31.0 36.6 30.1 31.7 33.0 28.4 , 29.5 27.3 28.8 22.8 26.1 36.0 29.0 33.7 30.1 28.9 39.5 34.1 30.3 29.6 25.1 28.6 28.5 28.8 23.2 Day 98 Day 105 Day 112 Day 119 28.1 33.5 29.0 28.2 23.9 25.7 31.1 29.6 27.5 24.8 28.6 27.9 28.4 26.8 24.8 26.4 28.7 27.3 26.6 24.0 -547- DuPont-5990 H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) ) DuPont-5990 Day 7 Day 14 Male, V - 100 mg/kg/day 646349 646463 646456 646469 646472 646385 646373 646435 646488 646455 646335 646477 646327 646403 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 24.4 25.8 28.0 24.3 21.0 24.5 28.8 24.4 29.3 26.5 24.4 25.7 25.0 23.2 22.5 25.8 26.3 27.8 26.5 26.6 23.6 26.3 26.8 25.9 27.2 20.3 26.1 27.1 25.8 26.3 19.9 25.0 19.8 27.7 21.7 27.5 29.4 28.8 26.1 23.1 26.4 32.2 27.6 27.4 27.0 24.9 24.3 26.3 26.9 24.4 27.7 27.6 27.0 29.7 27.8 25.2 28.2 26.8 28.1 30.6 21.9 26.0 27.5 28.7 29.0 23.0 25.5 28.7 23.2 20.6 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 Day 63 26.9 27.6 30.4 29.6 23.0 27.7 34.3 26.5 26.5 30.4 26.8 23.5 29.0 27.5 26.5 31.2 28.1 28.1 31.0 30.0 24.7 26.5 32.3 29.5 28.0 25.5 27.0 31.0 30.6 30.7 24.7 29.3 27.8 26.7 24.2 29.2 28.0 30.2 29.5 25.6 30.0 39.0 28.7 32.9 30.1 27.9 28.5 29.4 27.2 29.0 36.0 31.0 31.9 35.1 29.4 27.4 26.5 33.4 29.0 31.0 20.0 23.4 32.3 29.1 29.8 25.1 30.9 32.7 26.8 25.8 30.0 26.5 29.8 28.4 26.1 29.7 35.7 30.3 32.0 31.4 29.5 30.0 28.3 26.3 28.3 32.8 31.4 33.1 35.6 30.6 27.9 28.1 34.5 29.4 30.9 24.5 29.8 29.4 30.8 29.5 25.7 31.4 29.1 28.6 26.9 28.1 24.9 27.5 28.4 24.2 28.1 35.6 26.5 27.6 28.1 32.1 34.5 31.4 28.1 29.9 31.7 26.5 29.5 32.3 29.0 28.6 29.8 34.8 31.1 30.9 27.5 31.1 32.7 34.0 31.2 27.9 32.4 30.5 29.0 27.4 31.0 29.1 30.0 30.9 27.3 31.3 39.7 29.9 31.5 30.3 31.0 33.6 30.3 26.8 29.8 33.7 27.9 30.1 30.0 31.1 27.8 29.4 35.4 28.5 31.5 26.1 30.1 30.3 34.8 32.6 28.1 31.0 28.7 27.1 28.4 31.2 30.8 29.8 27.8 32.2 30.9 30.2 28.4 28.6 28.0 30.7 32.4 37.9 35.6 29.6 29.5 30.9 30.0 29.2 30.2 28.7 27.7 FD TEST DAY 57 28.3 27.5 27.9 28.1 24.8 27.2 29.3 32.0 29.8 29.2 29.5 29.0 33.5 33.3 29.8 29.8 26.8 26.8 28.4 28.6 31.0 34.9 29.2 29.6 31.2 34.3 26.1 26.7 28.1 28.7 29.0 30.1 28.3 33.3 27.9 29.5 25.1 28.0 29.2 31.4 29.2 30.6 27.6 28.2 25.8 28.4 Day 70 28.7 27.5 29.3 28.4 25.5 30.9 33.5 31.1 31.0 30.2 29.2 29.2 29.3 27.0 30.1 29.9 29.4 32.8 30.9 26.6 27.3 35.1 29.8 31.8 28.0 30.8 31.5 34.0 30.5 26.8 30.1 32.2 27.8 28.2 Company Sanitized. Does not contain TSCA CBI -548- Company Sanitized. Does not contain TSCA H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 77 Day 84 Male, V -- 100 mg/kg/day 646349 646463 646456 646469 646472 646385 646373 646435 646488 646455 646335 646477 646327 646403 646353 646341 646356 646330 646499 646400 646417 646338 646394 646387 646447 646336 646366 646496 646375 646465 646390 646429 646476 646348 646376 28.4 25.9 28.4 27.8 25.8 31.4 34.5 28.1 28.8 28.1 30.2 28.9 29.9 26.1 29.5 26.3 28.6 29.1 26.5 30.4 35.8 29.3 28.9 28.2 28.6 27.7 29.6 25.1 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 27.5 25.5 28.5 28.0 25.5 28.8 35.6 26.8 25.4 24.0 28.7 25.8 26.9 26.8 29.5 32.3 32.7 30.4 32.7 32.1 28.0 32.1 30.3 28.1 30.2 24.8 30.2 30.7 28.5 26.1 o DO DuPont-5990 ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI Day 7 Day 14 Male, VII - 500 mg/kg/day 646475 646388 646346 646433 646407 646437 646343 646347 646442 646413 646355 646344 646466 646391 646361 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 646384 646474 646448 646484 646337 646428 646369 646397 646372 17.4 17.9 21.7 18.8 21.8 14.6 18.5 16.6 16-5 17.9 17.0 16.8 17.7 16.0 15.1 14.5 18.6 22.3 18.3 18.5 20.8 17.6 21.0 20.4 16.9 21.7 21.9 17.5 21.2 16.7 19-0 20.0 18.8 21.3 20.3 18.5 20.0 15.3 20.5 19.3 18.6 13.2 18.5 21.0 19.0 23.3 26.3 24.8 22.2 24.9 20.4 22.8 22.2 21.3 25.2 22.3 20.7 25.1 23.3 16.9 19.8 24.0 29.5 24.9 24.6 25.6 21.8 23.5 25.4 27.1 26.7 31.3 21.9 30.0 21.2 25.4 26.9 25.3 26.5 22.4 24.4 27.5 23.3 25.2 22.5 22.6 22.3 21.7 26.7 22.9 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 26.4 32.2 27.9 24.7 28.2 22.8 27.8 25.4 24.9 27.5 24.8 24.3 29.6 27.9 22.5 23.1 28.9 31.1 25.7 25.3 29.2 22.9 25.1 29.2 31.0 30.3 35.6 22.8 30.8 24.1 30.1 29.7 31.0 30.5 23.4 22.9 30.1 22.7 28.2 25.5 26.0 26.3 23.4 28.7 24.7 27.5 31.5 27.3 26.7 27.4 24.5 28.3 27.0 26.7 29.8 26.0 23.8 31.9 28.4 23.0 23.6 30.6 31.9 26.9 26.2 29.1 23.2 26.6 30.3 32.3 33.5 37.3 22.0 33.5 24.9 29.9 29.9 29.0 32.3 26.3 24.7 33.2 23.7 29.3 25.6 27.7 28.2 25.8 30.2 23.3 25.3 23.1 28.2 26.3 27.6 25.2 25.6 23.3 28.6 26.4 24.4 23.3 29.0 26.5 26.8 24.7 25.6 23.1 26.9 22.6 25.0 24.4 25.2 25.5 31.6 30.7 30.2 32.0 23.5 25.1 25.1 26.7 30.8 26.4 32.6 33.1 26.2 29.1 24.8 24.0 29.7 30.9 22.8 25.0 25.4 26.8 29.0 31.4 S E 'TEST DAY 28 33.9 33.9 38.1 39.6 21.2 22.0 31.3 32.6 26.2 27.4 26.5 29.7 28.7 31.3 28.4 30.5 FD TEST DAY 31 25.3 26.1 27.2 28.1 33.5 34.1 23.7 22.3 28.9 29.3 25.2 28.8 28.0 27.3 30.0 28.1 24.6 25.7 30.1 31.0 23.4 25.8 -550- 25.2 30.1 28.5 25.9 31.6 27.1 30.0 26.2 25.3 29.8 24.4 27.1 31.5 31.8 28.8 27.2 34.5 35.3 27.4 23.9 31.0 24.8 27.5 28.1 34.0 37.1 21.2 36.6 24.6 29.8 30.5 31.5 24.6 25.2 33.3 21.1 32.0 29.4 27.0 30.2 27.4 30.0 26.7 28.0 30.4 30.3 25.4 32.2 27.6 33.5 26.5 27.8 30.0 26.9 27.2 31.6 31.6 28.3 25.0 33.2 32.8 30.3 22.4 33.1 27.4 26.6 35.4 34.2 33.3 24.0 37.7 25.9 30.3 30.8 33.6 24.7 25.9 34.4 24.2 31.7 31.3 29.0 33.4 28.3 29.7 26.3 Day 63 28.4 30.7 33.8 24.2 33.5 28.5 34.9 30.7 28.1 30.7 26.2 26.9 32.4 30.9 26.9 23.0 33.8 36.6 30.6 27.2 31.4 25.1 28.7 35.4 33.1 39.8 24.0 38.7 24.8 31.6 33.5 32.3 24.2 28.4 36.5 22.6 31.5 32.4 28.7 32.6 28.6 32.9 26.3 Day 70 28.4 27.4 32.5 26.2 32.2 27.9 32.7 28.5 27.7 26.1 27.6 28.8 30.6 33.7 28.3 24.6 31.7 35.3 31.9 27.5 30.8 26.1 27.8 37.2 36.1 38.3 24.1 36.2 24.7 28.7 30.9 33.4 24.5 27.8 36.4 22.7 30.2 31.4 25.4 31.0 28.9 33.1 26.4 )) ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations_______________________________________________________________ DuPont-5990 Company Sanitized. Does not contain TSCA CBI Day 77 Day 84 Male, VII - 500 mg/kg/day 646475 646388 646346 646433 646407 646437 646343 646347 646442 646413 646355 646344 646466 646391 646361 646382 646406 646491 646351 646405 646418 646362 646497 646401 646422 646498 646386 646332 646441 646452 646365 646393 646359 646380 646451 646364 646384 646474 646448 646484 646337 646428 646369 646397 646372 30.3 30.6 32.2 24.7 31.3 26.2 31.4 27.0 25.4 27.0 26.5 29.0 28.1 33.1 27.5 28.4 34.8 22.8 30.4 31.1 27.9 32.0 28.5 32.8 19.8 29.3 31.4 33.4 24.5 31.3 28.0 31.2 26.9 27.3 28.5 27.4 27.1 30.0 31.5 29.2 28.4 35.3 20.8 31.4 29.2 27.8 34.1 29.1 31.2 25.5 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 31.4 30.8 34.7 25.0 33.4 28.3 30.3 28.4 27.2 29.8 27.0 28.8 24.8 32.7 29.6 34.5 33.1 41.8 34.0 33.0 32.9 32.3 28.4 33.1 32.3 27.7 31.1 21.4 29.1 29.8 29.5 30.1 15.3 27.9 33.3 28.2 35.2 21.9 33.8 30.2 26.6 30.8 31.4 30.7 28.7 31.5 39.3 27.4 35.8 32.2 30.2 37.6 26.5 31.5 32.8 33.9 41.5 31.5 38.4 32.5 32.2 30.1 33.5 33.9 32.7 32.7 37.2 30.3 35.7 14.5 32.1 28.9 26.5 32.7 27.7 -551- 30.3 37.7 27.2 35.9 14.8 32.4 28.3 30.3 32.0 27.4 Company Sanitized. Does not contain TSCA H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 7 Day 14 Female, II - 0 mg/kg/day 646592 646560 646676 646665 646612 646538 646659 646649 646617 646537 646642 646530 646588 646597 646507 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 646581 646627 646565 646551 646511 646549 646652 646586 646613 19..7 16..3 20..6 27..1 18..8 20 .0 19 .5 21..5 19,.2 18..0 18..4 18..7 17..7 20..8 16..5 18..2 19,.8 17..3 20,.1 18..7 17..4 17,.6 18..5 18..6 21..1 19..7 16..2 19..7 18..4 19..8 18..8 16..8 19..6 14..7 21..4 17..5 18..4 20..6 21. 1 18. 7 18..4 17. 9 19. 5 20. 5 18. 0 21..1 15..1 21..4 18..6 20..8 19..8 22..2 22,.3 20..1 18..3 20..4 19..9 . 19..3 21..2 16..5 18..0 21..0 17,.9 22..9 19..9 18..6 19.,0 20..5 20.,7 22..9 20..9 16..9 19..2 17.,1 21..8 18..9 16..9 19. 2 22. 2 22. 2 17. 3 17. 5 20. 1 20. 3 19. 0 21. 4 17. 4 20. 4 20. 5 19. 1 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 21..0 14..7 23..6 20,.4 19..9 19..3 20..3 22..1 20..2 18..9 17..9 19..8 19..0 23..0 17..0 18..2 23..8 17..1 22..4 21..2 18.,0 17.,7 20..4 18.,3 22..4 20..6 15.,4 19..6 17..3 21..6 19..8 17..1 20..7 21.,5 22. 0 17. 5 18. 0 18. 9 19. 6 19. 1 20. 5 18. 7 20. 5 22. 3 20. 2 22..0 15..6 21..3 17..3 21..9 20..6 23..9 23,.5 20..3 20..5 18..6 21..2 18..6 22..3 18..6 21..5 23..0 19,.4 23..2 23..2 18..9 20..4 23..0 21.,2 22..7 20.,8 16..5 17..5 18..4 23..5 22..3 18..0 20.,7 19..8 24..1 18..5 18..4 18..4 23..2 20.,7 22. 3 18. 4 22. 1 22. 6 20. 5 22..2 15..0 24..7 20..1 23..6 22..1 24..9 26..1 22..6 19..3 28..8 21..4 20..2 24,.0 17..5 20..9 28..2 19..7 24..9 24..5 19..8 20..9 22..4 22.,0 23..5 20.,9 16..0 18..9 17..7 25.,2 22..8 18..9 21..7 20..0 24. 7 17. 8 19. 5 18. 5 24. 3 21. 4 24. 1 21. 0 25. 2 22. 8 22. 1 20..3 15..4 21..0 20..4 23..1 21..1 22,.4 23..2 20..3 19..6 19,.0 22..7 18..9 26..1 19..3 23,.3 26..2 20..3 26..2 24..5 19..7 20..5 22..0 22..7 24..9 21..7 17..8 19..9 19..8 23..6 23..0 19.,5 20.,3 21..2 23..4 20..1 20.,9 19..3 24.,3 22..5 23..6 23..2 26. 3 22..4 21. 5 21.,7 17..1 26..5 21.,5 24..4 22..7 26.,7 25.,5 22..5 22.,4 18.,8 22..3 19..9 26..6 20.,6 21.,9 26.,6 20.,5 27. 4 24..5 20..5 19..8 23..1 22..7 23..3 20..5 16..6 18. 3 19.,6 24. 1 24. 9 20. 0 20. 1 20. 7 23. 8 18. 7 18. 3 18. 0 27. 2 22. 5 23. 3 22. 9 23. 7 23. 4 21. 4 Day 56 21..3 17..1 23..0 22..7 23..2 22..6 25..5 25..6 21..8 18..6 20..3 22..3 18,.7 25,.1 19..9 22..1 27,.5 19..2 25..2 24,.0 19..7 20..2 21..5 20..7 23..8 21..5 16..0 19.,7 20..3 24..3 24..8 19.,3 22..0 20.,7 26..0 18.,5 20..8 19.,5 28..3 23..7 22..3 25..5 25. 1 22. 6 22. 4 Day 63 20..5 16..7 25..5 24..7 24..8 23..7 25..4 24..2 22,.2 18..9 18..8 21..0 17..2 25..8 19..4 22..1 22,.5 18..4 26..7 23..0 20..5 20..0 18..3 22..6 21..3 19..0 15..5 20..2 21..3 22..5 22.,6 15..8 23..8 22.,1 20..1 18.,1 20..7 19.,5 26..3 20..9 21..3 20..7 24. 9 20. 5 22. 4 DuPont-5990 Day 70 22 1 15 4 25 0 24 7 19 6 25 9 24 3 20 7 23 9 16 5 14 4 23 6 19 9 22 7 18 3 26 0 23 4 21 7 23 9 21 8 19 8 14 3 20 2 17 7 22 8 19 4 20 5 20 9 22 1 21 9 21 2 19 7 18 9 21 4 20 6 20 1 21 7 26 6 19 4 23 7 22 2 23 8 22 2 20 6 20, 1 Company Sanitized. Does not contain TSCA CBI ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations ) INDIVIDUAL FOOD CONSUMPTION (g/day) Day 77 Day 84 Day 91 Day 98 Day 105 Day 112 Day 119 Female, II - 0 mg/kg/day 646592 646560 646676 646665 646612 646538 646659 646649 646617 646537 646642 646530 646588 646597 646507 646653 646575 646585 646622 646550 646526 646503 646644 646604 646651 646552 646606 646557 646591 646544 646646 646520 646569 646654 646668 646580 646581 646627 646565 646551 646511 646549 646652 646586 646613 21.7 15.5 20.7 24.1 26.4 22.0 26.0 23.3 22.6 20.2 20.9 20.8 19.2 24.4 19.2 17.7 20.5 20.6 24.8 22.4 23.4 25.5 23.9 22.3 20.4 20.2 14.6 21.9 21.5 22.5 20.9 24.1 23.1 21.2 19.2 19.4 21.5 . 19.0 22.4 18.6 22.0 13.7 19.9 23.9 24.1 21.1 20.4 20.4 21.0 20.3 AK TEST DAY 89 19.9 21.5 18.4 21.3 19.0 26.6 15.5 22.1 18.1 20.6 19.4 25.7 21.3 22.4 20.9 22.7 22.8 21.6 16.5 19.0 18.6 22.9 16.9 21.1 20.7 22.5 20.5 19.9 18.4 21.9 19.4 24.6 21.3 22.2 24.5 22.1 21.3 22.7 21.7 20.0 24.4 19.9 19.1 20.7 21.7 22.6 21.7 18.3 24.4 25.1 22.1 21.2 21.2 22.9 26.1 16.4 18.1 19.9 21.8 27.4 22.0 22.1 23.2 27.0 24.9 22.1 21.5 19.5 25.5 17.2 17.5 18.4 21.3 25.1 21.2 20.6 22.4 25.8 22.3 21.6 -553- ) DuPont-5990 H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 Day 7 Day 14 Female, IV - 25 mg/kg/day 646522 646660 646502 646595 646567 646673 646635 646664 646621 646576 646625 646568 646626 646531 646636 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 17.8 16.6 16.0 17.1 17.6 17.0 18.4 17.8 20.3 22.6 18.6 20.8 16.2 18.5 16.4 17.4 19.7 22.0 21.1 19.5 17.6 17.2 23.4 17.0 17.1 19.4 19.5 19.8 19.2 19.4 17.1 18.8 20.9 20.9 18.0 19.2 18.1 17.7 18.3 17.3 20.8 19.8 22.4 23.0 22.6 18.0 21.2 16.4 20.1 17.6 20.8 21.1 24.4 21.1 21.9 19.1 18.5 24.5 18.5 18.4 20.5 22.0 19.4 19.0 22.2 18.9 19.5 19.7 21.2 18.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 18.9 18.1 17.5 18.8 18.6 22.7 18.9 18.8 23.7 24.1 20.0 22.1 16.3 21.1 19.1 21.6 21.2 26.1 25.0 22.3 19.0 18.8 26.7 19.3 22.0 20.4 21.1 19.6 19.3 21.1 19.1 20.9 20.7 22.5 20.6 20.7 18.7 17.0 19.2 20.0 24.2 20.0 20.4 21.8 23.1 19.8 23.1 15.8 21.7 18.1 19.3 22.6 22.7 23.4 23.4 19.9 19.1 24.5 19.8 20.3 22.7 22.8 19.9 19.9 21.2 18.4 19.5 20.9 23.9 21.2 20.6 17.8 18.8 21.1 20.1 26.7 20.3 21.1 24.2 22.7 21.1 23.8 15.8 23.4 19.3 22.1 23.0 26.1 21.3 24.9 19.6 19.7 24.0 19.5 20.8 22.5 23.6 19.1 21.0 24.1 20.6 20.4 21.0 24.5 21.3 18.7 17.2 18.0 18.2 19.6 23.7 21.7 20.0 24.5 21.3 21.0 25.5 16.6 22.4 19.8 22.3 22.1 28.1 23.8 25.9 22.0 18.5 24.6 21.2 21.2 21.1 22.9 18.8 20.9 22.6 22.2 20.2 22.0 22.9 20.6 20.6 19.6 19.3 23.9 23.9 27.3 23.8 22.1 26.5 23.6 21.8 25.7 15.7 22.7 19.6 23.8 22.1 28.7 21.5 27.3 22.9 18.8 27.5 20.4 19.0 21.1 21.8 18.8 21.2 21.1 22.5 19.7 21.0 22.5 21.7 20.4 20.5 19.4 20.3 22.0 24.8 23.9 20.7 24.8 24.6 20.8 25.0 15.8 20.9 19.2 21.8 22.4 26.7 20.9 26.4 21.8 16.9 26.5 19.4 19.1 20.5 22.3 20.5 22.6 21.0 23.3 20.0 21.2 23.0 24.1 Day 63 20.1 19.3 18.9 19.3 21.9 26.1 21.3 18.7 24.8 26.3 20.3 24.9 14.8 21.5 18.3 19.3 21.6 23.2 20.5 24.0 19.7 17.1 25.5 19.1 18.7 19.4 22.8 19.7 20.0 20.5 23.0 20.0 20.6 21.5 20.4 Day 70 19.5 18.2 17.4 20.0 21.7 24.9 21.1 18.9 24.2 25.5 20.9 25.1 15.2 22.0 18.0 18.5 20.7 22.8 20.4 25.2 17.8 18.2 23.4 19.5 19.1 18.8 20.3 17.6 18.8 21.5 22.8 19.2 22.0 21.3 21.2 Company Sanitized. Does not contain TSCA CoD Company Sanitized. Does not contain TSCA CBI H90--2D47a6y8G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations Day 77 Day 84 Female, IV - 25 mg/kg/day 646522 646660 646502 646595 646567 646673 646635 646664 646621 646576 646625 646568 646626 646531 646636 646638 646559 646598 646561 646573 646504 646587 646631 646529 646603 646554 646579 646564 646672 646584 646543 646596 646558 646670 646553 19.7 19.0 16.4 20.2 23.7 25.1 20.5 19.3 21.6 23.9 20.6 27.0 15.0 22.2 18.8 18.7 19.3 17.8 19.0 24.1 26.7 21.4 21.4 20.6 24.8 20.5 22.9 , 15.6 21.7 19.3 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 18.2 18.5 17.4 16.6 21.9 26.0 20.5 18.7 26.3 22.1 17.8 22.8 15.3 20.3 19.9 22.3 25.8 16.4 24.3 21.6 21.8 27.6 12.0 22.0 22.4 22.0 27.5 17.5 23.0 22.5 21.4 26.9 17.6 20.2 21.5 -555- DuPont-5990 H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 Day 7 Day 14 Female, VI - 100 mg/kg/day 646608 646556 646629 646510 646578 646505 646534 646624 646501 646633 646656 646630 646634 646533 646632 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 16.0 16.8 16.5 18.6 18.0 16.6 18.4 17.5 16.9 17.8 19.1 19.5 16.2 17.0 16.8 18.9 20.9 19.3 15.8 18.0 15.6 18.2 15.3 17.4 19.0 17.9 17.6 13.8 19.5 17.3 16.5 18.3 19.6 15.0 16.7 . 19.3 19.3 19.5 22.1 19.8 20.4 18.6 18.6 19.5 19.7 21.1 21.8 17.4 18.3 20.0 19.4 22.2 22.2 19.3 20.8 19.2 19.7 16.9 20.2 20.8 20.1 19.4 18.8 21.5 18.8 17.0 20.5 22.5 16.4 19.5 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 16.2 20.2 20.4 22.3 19.2 21.6 19.5 19.3 20.2 19.6 21.0 23.2 19.7 19.6 20.2 19.9 22.3 23.0 18.6 20.5 19.7 21.5 19.3 21.1 21.0 21.3 20.1 18.3 21.9 21.2 18.3 21.6 22.2 16.0 19.1 19.2 20.5 20.7 23.4 19.0 21.1 17.9 18.8 21.2 22.7 20.9 24.9 18.5 19.3 19.2 21.6 22.9 19.8 19.7 18.6 19.4 21.2 18.5 19.5 22.4 21.4 21.1 19.7 22.6 21.8 19.9 20.7 22.1 17.3 20.4 18.9 24.2 21.1 24.0 19.4 22.6 20.2 19.8 22.3 24.0 20.7 27.3 19.4 20.9 20.8 22.3 22.7 23.2 20.9 21.8 20.6 22.1 20.7 20.6 22.9 21.5 22.0 19.7 15.0 21.3 19.3 22.1 22.7 17.1 21.3 16.8 24.3 20.0 21.8 20.7 22.2 18.9 18.4 19.0 21.1 22.9 27.8 19.3 20.0 22.2 22.8 21.9 18.2 21.4 20.7 19.3 22.3 18.9 19.0 22.6 21.2 20.2 20.6 23.9 23.1 20.0 23.1 19.9 17.4 21.0 18.7 25.8 23.8 24.3 20.6 26.8 22.8 20.3 22.7 24.3 25.5 27.6 21.3 20.6 21.9 23.5 23.9 23.7 21.4 21.0 22.6 23.1 19.8 22.2 22.7 21.8 21.8 19.9 26.7 25.1 20.9 23.5 22.1 18.6 22.9 18.4 28.2 21.9 24.5 18.0 26.7 19.8 20.6 23.0 23.0 24.5 27.0 19.7 20.4 20.7 23.5 24.3 24.0 22.5 20.7 20.1 24.5 20.1 21.0 21.9 21.4 20.6 19.7 25.4 22.3 19.2 23.7 21.2 19.0 22.5 Day 63 18.4 27.7 21.5 25.7 22.0 28.1 19.1 20.0 25.2 22.2 23.0 27.7 20.5 19.7 21.2 23.2 23.6 24.7 19.2 21.1 21.0 25.6 21.5 21.6 22.7 21.6 20.2 19.2 25.6 24.1 18.6 21.3 21.5 18.7 24.4 Day 70 18.1 25.4 20.7 25.8 21.0 25.6 20.1 20.2 22.0 21.1 20.1 26.4 21.3 20.4 21.3 22.1 23.8 22.1 19.1 19.1 20.2 22.8 20.0 22.7 20.9 20.8 21.4 19.0 25.4 24.4 19.7 22.2 20.6 18.7 22.4 Company Sanitized. Does not contain TSCA CoD Company Sanitized. Does not contain TSCA C8I ) H-24768: Subchronic Toxicity 90-Day Gavage Study with One-Generation Reproduction Evaluations ) Day 77 Day 84 Female, VI - 100 mg/kg/day 646608 646556 646629 646510 646578 646505 646534 646624 646501 646633 646656 646630 646634 646533 646632 646547 646666 646607 646524 646600 646648 646594 646546 646661 646671 646521 646590 646645 646555 646605 646589 646615 646527 646647 646675 18.1 25.8 20.7 22.7 21.5 26.8 18.7 20.1 23.2 22.0 22.8 27.9 19.2 21.0 20.1 17.1 24.1 19.7 23.5 21.9 29.4 19.3 19.9 23.7 23.3 20.1 27.1 19.5 20.8 21.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 16.4 24.1 19.4 20.3 20.9 27.9 19.1 19.0 23.0 21.9 21.2 26.4 18.3 20.6 20.3 26.0 28.9 21.1 21.9 21.5 22.0 26.7 21.1 23.8 20.9 24.3 26.7 21.6 25.7 21.2 23.2 24.1 18.9 24.1 20.5 -557- ) DuPont-5990 H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 7 Day 14 Day 21 Day 28 Day 35 Day 42 Day 49 Day 56 Female, VIII - 500 mg/kg/day 646657 646610 646536 646593 646509 646669 646614 646609 646577 646535 646667 646523 646528 646601 646620 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 646548 646508 646650 646637 646545 646618 646506 646542 646599 14.9 14.4 18.1 9.7 14.1 9.7 15.8 13.0 1.1 10.3 14.4 11.3 12.0 14.0 11.5 11.2 3.4 15.3 13.8 15.7 12.7 14.4 12.2 11.8 10.7 13.2 12.5 13.0 12.3 12.0 12.3 12.2 8.7 14.4 14.2 12.1 10.2 14.5 14.2 11.4 10.1 13.8 14.5 16.8 16.1 17.6 18.0 23.5 15.8 18.9 15.5 17.4 14.3 14.5 18.9 16.6 14.8 , 15.1 17.8 15.3 15.1 14.2 22.4 19.1 20.1 18.1 19.3 17.4 15.2 15.3 18.7 15.3 15.0 15.6 16.0 17.0 16.8 19.1 20.1 18.8 17.8 16.4 19.7 16.2 15.4 18.3 18.8 17.6 19.5 18.6 20.1 20.0 22.9 16.8 21.1 16.5 20.6 18.8 16.4 20.1 18.1 16.6 17.6 20.6 16.0 16.7 16.6 21.9 21.0 22.6 20.4 19.1 19.5 16.9 15.7 20.6 20.4 17.1 17.2 17.3 17.2 17.7 17.5 20.8 22.2 20.4 18.6 19.5 18.3 17.9 18.9 21.2 16.1 20.8 21.3 19.7 19.1 22.9 16.4 19.8 16.5 22.0 22.7 17.6 21.6 20.7 16.5 17.6 21.6 17.0 16.3 16.6 22.5 24.1 24.7 21.6 20.0 19.4 18.2 16.6 20.4 18.7 17.4 16.6 19.4 19.2 16.2 19.1 21.9 21.9 20.1 19.6 20.3 18.8 17.8 18.5 23.3 19.4 23.9 20.8 22.9 20.8 24.7 19.7 21.9 16.6 22.3 23.0 17.4 22.3 22.3 20.4 23.3 22.5 18.8 16.7 20.0 27.4 26.7 27.1 24.0 24.1 21.6 21.3 18.5 22.8 20.9 20.8 21.8 21.3 20.6 19.0 20.3 22.1 22.1 23.9 20.9 22.6 20.1 20.0 21.1 22.7 20.4 25.7 23.1 20.5 19.0 22.0 15.7 17.5 15.6 21.6 21.0 15.8 21.1 21.8 18.5 19.0 23.7 19.0 17.4 20.1 26.7 24.8 25.3 22.0 22.0 20.3 21.2 21.3 20.2 19.7 18.9 20.5 20.3 21.9 19.5 17.1 23.0 24.4 21.8 19.8 22.3 20.9 20.4 20.9 21.9 20.0 25.2 22.0 23.5 22.5 25.4 22.6 23.2 18.1 22.6 25.6 18.4 23.2 21.9 20.6 22.3 22.1 17.5 16.2 17.6 23.7 30.1 29.8 23.4 21.6 20.7 20.1 17.1 21.3 21.2 20.6 20.2 21.1 20.8 18.8 20.1 24.7 23.1 23.7 21.5 22.8 20.9 21.4 21.9 23.4 20.5 24.9 24.4 21.0 20.3 27.2 19.2 22.2 18.4 26.1 22.1 19.5 26.9 19.7 19.2 21.1 23.8 18.2 16.5 20.8 22.0 28.4 24.5 23.6 22.2 21.3 25.0 21.0 22.6 22.4 20.9 21.2 20.4 22.9 19.4 22.7 25.7 24.8 25.9 18.8 24.0 20.5 20.5 20.8 23.5 18.5 25.4 22.9 Day 63 23.4 22.1 26.1 19.3 22.5 19.2 24.6 24.1 19.0 25.8 20.8 19.3 21.6 26.5 19.4 17.1 18.3 20.9 27.0 25.6 27.0 21.1 20.2 21.3 19.1 21.1 21.7 20.8 21.0 21.3 23.1 22.7 21.6 26.0 23.4 23.7 22.2 24.3 22.4 18.3 23.1 23.4 20.1 26.5 23.9 Day 70 23.6 22.5 25.4 18.8 23.1 19.2 21.3 26.8 19.3 23.7 21.2 19.3 23.1 24.6 18.7 16.9 18.9 20.9 25.9 23.8 24.7 20.9 20.6 22.5 17.3 22.0 18.5 20.8 20.3 20.9 21.2 20.6 22.1 23.7 23.0 25.7 23.3 24.0 19.8 22.7 20.4 23.7 20.0 27.1 22.5 Company Sanitized. Does not contain TSCA CBI -558- ) H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations__________________________________________________________________DuPont-5990 Day 77 Day 84 Female, VIII - 500 mg/kg/day 646657 646610 646536 646593 646509 646669 646614 646609 646577 646535 646667 646523 646528 646601 646620 646662 646583 646623 646619 646539 646628 646616 646563 646641 646572 646512 646566 646570 646602 646582 646655 646663 646640 646574 646532 646540 646548 646508 646650 646637 646545 646618 646506 646542 646599 23.1 23.6 25.3 21.1 24.1 20.0 21.9 25.9 19.1 22.7 20.5 19.2 22.8 24.5 18.7 26.6 24.5 24.2 20.7 24.6 20.4 23.0 19.5 27.1 23.4 24.1 23.7 23.2 21.1 22.9 17.4 22.3 10.6 20.1 23.8 21.4 20.7 21.2 22.9 19.0 24.8 23.5 24.4 23.1 22.1 22.2 23.4 21.6 26.4 24.0 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 91 Day 98 Day 105 Day 112 Day 119 21.9 24.5 23.6 22.0 21.9 18.1 21.9 25.0 24.2 20.7 21.7 19.6 21.8 24.6 17.9 23.1 22.3 26.0 27.4 24.4 24.7 21.5 12.9 25.0 22.9 23.1 21.0 23.5 27.2 23.2 21.4 19.8 7.2 22.2 21.6 26.6 21.3 23.0 20.9 21.1 20.9 23.0 19.2 24.6 22.6 28.2 25.7 24.2 25.9 24.7 22.1 22.5 20.1 25.6 21.8 25.5 22.8 23.7 25.0 18.7 21.1 21.6 19.5 25.0 22.4 26.0 26.6 23.4 26.1 24.3 22.3 22.7 19.9 29.0 23.2 26.2 27.8 22.4 23.8 17.5 22.4 21.0 17.5 27.2 20.0 Company Sanitized. Does not contain TSCA CBI -559- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX E INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA -560Company Sanitized. Does not contain TSCA CBI H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Critical Dates EXPLANATORY NOTES Day 70 Last day data from the male and female rats designated for reproduction evaluations were reported with the subchronic toxicity animals and are reported as "removed from study" in this appendix. Clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 85 Ophthalmology examinations were conducted on rats designated for the 90-day exposure period. Day 95 Male rats designated for the 91-day exposure period were sacrificed. Day 96 Female rats designated for 91-day exposure period were sacrificed. Day 123 Male rats designated for the one-month recovery were sacrificed. Day 124 Female rats designated for the one-month recovery were sacrificed. Day 183 Male and female rats designated for the 3-month recovery period were sacrificed. Any clinical sign observed on consecutive data collection days is assumed to have been present during the interim between observation days, and will be reported as having been observed over the period from the first-last day observed. Ophthalmology Evaluation observations and Clinical Pathology Evaluations are documented as Clinical Observations and interrupt the continuing clinical observations. All ophthalmology observations from test day 85 are those observed during the examination by the veterinary ophthalmologist. -561Company Sanitized. Does not contain TSCA CBI ) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal MI 646482 MI 646427 MI 646360 MI 646489 MI 646379 MI 646485 MI 646420 Observation General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Right Sacrificed by design Days 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,49-84,91-95 39,95 85 42 95 Company Sanitized. Does not contain TSCA CBI -562- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 646374 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 39,95 85 95 MI 646367 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design 0-14 39,96 85 35,42-84,91-96 21-28 96 MI 646457 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right. Black Stain Fur/Skin, Abdomen, Red Stain Fur/Skin, Inguen, Red Stain Fur/Skin, Perineum, Red Sacrificed in extremis 0,14-28,35-49 0,3,21,34,55 9 7 57 57 56-57 57 MI 646325 General observation. No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,119-183 109 0,3,21,34,55,89,93,126,140,161 9,76,97,102,116,183 105,112 183 MI 646396 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Sacrificed by design 0,7,14-28,35-49,161-183 89 0,3,21,34,55,93,126,140,161 9,76,97,102,109,116,183 77-84,91,98,105,112,119-133 140-154 63-70,77-84,91,98,105,112,119-154 56 183 Company Sanitized. Does not contain TSCA CBI -563- ) '1 H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 646495 General observation. No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Hair Loss, Forepaw, Right Sacrificed by design 0,7,14-28,35 126 0,3,21,34,55,89,93,102,109,140,161 9,76,97,116,183 42-49,56-70,77-84,91,98,105,112, 119-183 183 646468 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Hair Loss, Shoulder, Left Head Tilt Wound, Superficial, Shoulder, Left Wound, Superficial, :Face Sacrificed by design 0,3,21,34,55,89,93,116,126,140,161 9,76,97,102,109,183 14-28,35-49,56-70,77-84,91,98, 105.112.119- 126 133-140 147-183 49,56-70,77-84,91,98,105,112,119-183 105.112.119- 183 7,14-28,35-42 14 183 MI 646490 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646440 General observation. No Abnormality Detected Removed from study 0-70 70 MI 646424 General observation. No Abnormality Detected Removed from study 0-70 70 MI 646402 General observation, NO Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -564- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 646392 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-28 35-70 70 MI 646473 General observation. No Abnormality Detected Hyperreactive Removed from study 0-42,56 49 70 MI 646395 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646352 General observation, No Abnormality Detected Ruffled Fur Stain Fur/Skin, Face, Red Removed from study 0-7,2114 14 70 MI 646357 General observation. No Abnormality Detected Removed from study 0-70 70 MI 646409 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Removed from study 0 7,42-70 14-35 70 HI 646328 General observation. No Abnormality Detected Removed from study 0-70 70 MI 646479 General observation, No Abnormality Detected Hyperreac tive Removed from study 0-49 56-70 70 MI 646470 General observation, No Abnormality Detected Removed from study, 0-70 70 MI 646461 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646480 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -565- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 646383 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646445 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-28 35-70 70 MI 646358 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646425 General observation. No Abnormality Detected Removed from study 0-70 70 MI 646408 General observation, No Abnormality Detected Removed from study 0-70 70 MI 646459 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Sacrificed by design 0-14 123 85 56-84,91-123 21-77 123 MI 646460 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-123 123 85 123 MI 646416 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Urine, Present, Yellow Sacrificed by design 0-56 123 85 105-123 63-84,91-98 112-119 123 Company Sanitized. Does not contain TSCA CBI -566- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations ) DuPont-5990 Company Sanitized. Does not contain TSCA CBI INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI 646371 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-123 123 85 123 MI 646411 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-123 123 85 123 MI 646398 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-123 123 85 123 MI 646487 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Sacrificed by design 0-7,42-84,91 123 85 14-35 123 MI 646445 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Left Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design 0,56 123 85 63-84,91-123 35-49 7-28 123 MI 646432 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Right Sacrificed by design 0-84,91-98 123 85 105-123 123 MI 646494 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Hair Loss, Forepaw, Right Sacrificed by design 0-28 123 85 35-49,70-84,91-123 56-63 119-123 123 MI 646492 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Base of tail Hair Loss, Forepaw, Bilateral Sacrificed by design 0-28 39,95 85 77-84,91 35,42-84,91 95 -567- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M III 646454 M III 646399 M III 646370 M III 646443 M III 646423 M III 646421 M III 646471 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design Left General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Sacrificed by design Left General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-7 39,95 85 14-35,42-84,91-95 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42-84,91-95 39,95 85 95 0-35,42 39,95 85 49-84,91-95 95 0-35,42-84,91-95 39,95 85 95 Company Sanitized. Does not contain TSCA CBI -568- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M III 646426 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Retina, Retinal Degeneration Focal, Right Sacrificed by design 0-35,42-84,91-95 39,95 85 95 M III 646414 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 39,95 85 95 M III 646458 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 95 39 85 95 M III 646368 General observation, No Abnormality Detected Eye Observations, Closed, Left Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Opaque, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Dark, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,35-49,56-70,91,105,112 119,147-183 133-140 154-183 126-147 34,55 21,89,93,116 0,3,9,76,97,102,109,126,140,161,183 77-84 98 183 M III 646438 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-183 109 21,34,116,126,140,161 0,3,9,55,76,89,93,97,102,183 183 Company Sanitized. Does not contain TSCA CBI -569- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M III 646436 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,98, 105,112,119-183 0,3,21,34,89,93,109,116,126,140,161 9,55,76,97,102,183 91 183 M III 646449 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Dark, Left Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,119-183 0,3,21,34,89,93,102,116,126,140,161 9,55,76,97,109,183 105,112 183 M III 646453 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Eye Observations, Dark, Right Discharge, Nose, Black Sacrificed by design 0,7,14-28,35,49,56-70,77-84,91,126-140 126 0,3,21,34,89,93,102,116,140,161,183 9,55,76,97,109 182-183 147-182 42,98,105,112,119 183 M III 646378 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646483 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646363 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Perinasal, Black Removed from study 0-7,21-28 35-70 14 70 M III 646334 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -570- )) H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M III 646493 General observation, No Abnormality Detected Removed from study 0-70 70 M III 646404 General observation, No Abnormality Detected Wound, Superficial, Mouth Removed from study 0-42,49-70 47 70 M III 646415 General observation, No Abnormality Detected Removed from study 0-70 70 M III 646410 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646340 General observation, No Abnormality Detected Hair Loss, Forepaw, Right Removed from study 0-7,56-70 14-49 70 M III 646354 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646467 General observation, No Abnormality Detected Removed from study 0-70 70 M III 646381 General observation. No Abnormality Detected Discharge, Mouth, Clear Removed from study 0-63 70 70 M III 646342 General observation, No Abnormality Detected Removed from study 0-70 70 M III 646450 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646326 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-28 35-70 70 M III 646377 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -571- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M III 646478 General observation, No Abnormality Detected Removed from study 0-70 70 M III 646350 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-7 14-70 70 M III 646333 General observation. No Abnormality Detected Removed from study 0-70 70 M III 646486 General observation, No Abnormality Detected Wound, Superficial, Shoulder, Right Stain Fur/Skin, Shoulder, Left Removed from study 0,14-49 7 56-70 70 Company Sanitized. Does not contain TSCA CBI -572- H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 646349 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Hair Loss, Forepaw, Right Sacrificed by design 0-28 39,95 85 35,42-84,91-95 56-84,91-95 95 MV 646463 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 39,95 85 95 MV 646456 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 39,95 85 95 MV 646469 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-95 95 39 85 95 3oo MV 646472 General observation, No Abnormality Detected 0 Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected 0-35,42-84,91-95 39,95 85 or Sacrificed by design 3 95 < 35OD MV 646385 General observation. No Abnormality Detected 0-35,42-84,91-95 J Eye Observations, Bled via Orbital for Clin Path, Bilateral 95 Eye Observations, Bled via Orbital for Clin Path, Left 39 aN No Ophthalmological Abnormalities Detected 85 <9 Sacrificed by design 95 O MV 646373 General observation, No Abnormality Detected 0 D Eye Observations, Bled via Orbital for Clin Path, Left w Discharge, Mouth, Clear q No Ophthalmological Abnormalities Detected ^ Sacrificed by design O s5H3r' Cfl O O> CO 0-35,42-56,70-84,91-95 39,95 63 85 95 )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 646435 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Wound, Superficial, Forepaw, Right Sacrificed by design Left 0-35,42-84 39,95 85 91-95 95 MV 646488 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral General Teeth Observations, Absent General Teeth Observations, Maloccluded Discharge, Mouth, Red Discharge, Eye left, Red No Ophthalmological Abnormalities Detected Sacrificed by design 0-7 39,95 14-35,42-84,91-95 13 13 14 85 95 MV 646455 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design 0-35,42-77 39,95 85 91-95 84 95 MV 646335 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left Discharge, Nose, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112 109 0,3,21,34,76,89,93,126,140,161 9,55,97,102,116,183 119-183 147-154 183 Company Sanitized. Does not contain TSCA CBI -574- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 646477 General observation. No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Face, Right Found dead in cage. 0,7 14-28,35-51 0,3,21,34 9 28,35-42 51 MV 646327 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-183 109 0,3,21,34,89,93,116,126,140,161 9,55,76,97,102,183 183 MV 646403 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye left. Black Hair Loss, Base of tail Hair Loss, Forelimb, Right Stain Fur/Skin, Shoulder, Bilateral, Yellow Stain Fur/Skin, Shoulder, Right, Yellow Sacrificed by design 0,7,14-28,35,49 9,89,93,116,126,140,161 0,3,21,34,102,109 55,76,97,183 42 133-183 70,77-84,91,98,105,112 147-182 56-70,77-84,91,98,105,112,119-140 183 MV MV 646353. General observation. No Abnormality Detected Removed from study 646341 General observation. No Abnormality Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Face, Red Removed from study 0-70 70 0-21 35-70 28-70 49 70 Company Sanitized. Does not contain TSCA CBI -575- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 646356 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646330 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646499 General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral Removed from study 0-42 49-70 70 MV 646400 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-28 35-70 70 MV 646417 General observation, No Abnormality Detected Hair Loss, Forepaw, Left Removed from study 0-42 49-70 70 MV 646338 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646394 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646387 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646447 General observation, No Abnormality Detected Hair Loss, Hindlimb, Right Removed from study 0-42,56-70 49 70 MV 646336 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646366 General observation. No Abnormality Detected Removed from study 0-70 70 MV 646496 General observation. No Abnormality Detected Discharge, Mouth, Clear Removed from study 0-56,70 63 70 Company Sanitized. Does not contain TSCA CBI -576- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 646375 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646465 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646390 General observation. No Abnormality Detected Wound, Superficial, Hindpaw, Bilateral Stain Fur/Skin, Head, Red Removed from study 0-63 70 70 70 MV 646429 General observation, No Abnormality Detected Discharge, Mouth, Clear Removed from study 0-49,63-70 56 70 MV 646476 General observation, No Abnormality Detected Discharge, Mouth, Clear Removed from study 0-42,70 49-63 70 MV 646348 General observation, No Abnormality Detected Removed from study 0-70 70 MV 646376 General observation, No Abnormality Detected Eye Observations, Opaque, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Maloccluded Discharge, Eye left, Black Sacrificed by design 7,42-49,56-70,77-84,91,98,105 140-183 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161,183 8,14-28,35 112,119-147 183 Company Sanitized. Does not contain TSCA CBI -577- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646475 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye left. Black Hair Loss, Abdomen, Right Hair Loss, Hindlimb, Right Hair Loss, Face, Left Stain Fur/Skin, Perineum, Yellow Globe, Phthisis bulbi, Left Sacrificed by design 0-28 63-84,91-95 84.91-95 42-49 39 95 42-49 35,42-84,91-95 84.91- 95 56-63 63 85 95 M VII 646388 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Wet Fur, Perineum Sacrificed by design 0-28,42-56 39,95 85 35,63-84,91-95 95 95 95 M VII 646346 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Stain Fur/Skip, Perineum, Yellow Stain Fur/Skin, Chin, Red Stain Fur/Skin, Face, Red Sacrificed by design 0-35,42 39,95 85 49-84,91-95 49 63-84,91-95 95 M VII 646433 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Hindlimb, Right Hair Loss, Side, Bilateral Sacrificed by design 0-28 39,95 85 49-84,91-95 49-84,91-95 35,42 70-84,91-95 95 Company Sanitized. Does not contain TSCA CBI -578- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646407 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design 0-35,42-56,70 39.95 63.95 85 77-84,91-95 77-84,91-95 95 M VII 646437 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Ventral Hair Loss, Perineum Sacrificed by design 0-7 39,95 85 14-35,42-84,91-95 14-35,42-84,91-95 95 M VII 646343 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design 0-28 39,95 95 85 63-84,91-95 49-56 42-84,91-95 35 95 M VII 646347 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 0-35,56 39,95 85 42-49,63-84,91-95 95 Company Sanitized. Does not contain TSCA CBi -579- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646442 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Sacrificed by design 0-35,42-56 39,95 63,77-84 85 70-77 77,91-95 95 M VII 646413 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Retina, Retinal Degeneration Focal, Right Sacrificed by design 0-35,42-84,91-95 39,95 85 95 M VII 646355 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Red Stain Fur/Skin, Face, Red Sacrificed by design 0,7,14-21,35,56,133-183 0,3,21,34,89,93,109,126,140,161 9,55,76,97,102,116,183 42 63 28,49,63-70,77-84,91,98,105,112,119-126 183 M VII 646344 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Mouth, Clear Discharge, Eye left. Black Hair Loss, Forelimb, Left Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Sacrificed by design 0,7,14-28,42,56,98,105,112,119-183 183 0,3,21,34,89,93,109,116,126,140,161 9,55,76,97,102 49 35 77-84 63-70,77-84 77-84,91 183 Company Sanitized. Does not contain TSCA O CD H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646466 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Nose, Black Hair Loss, Abdomen, Bilateral Abnormal Gait, Hindiimb. Left, Severe Scab, Inguen Wound, Superficial, Perineum Mass Inguen, Right, Mass #1, Ulcerated, 0.5 cm Mass Inguen, Right, Mass #1, Not Ulcerated, 0.5 cm Sacrificed by design 0,21-28,35-49,56-70,77-84,91, 98,105,112,119-161 93,161 0,3,21,34,109,116,126,140 9,55,76,89,97,102,183 168-175 7,14 74 183 182 175 168 183 M VII 646391 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0,7,14-28,35-49,56,70,77-84,98,105 109,161,183 0,3,21,34,89,93,116,126,140 9,55,76,97,102 91 126-175 119-175 112,182-183 63 183 VII 646361 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right. Black Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0,7,14-28,35-49,56,98,112,119-183 93 0,3,21,34,89,116,126,140 9,55,76,97,102,109,161,183 105 63-70,77-84,91 183 Company Sanitized. Does not contain TSCA O CD )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646382 General observation, No Abnormality Detected Wound, Superficial, Hindpaw, Left Stain Fur/Skin, Perineum, Yellow Removed from study 0-63 70 70 70 M VII 646406 General observation, No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-63 70 70 M VII 646491 General observation, No Abnormality Detected Removed from study 0-70 70 M VII 646351 General observation. No Abnormality Detected Discharge, Mouth, Clear Stain Fur/Skin, Perineum, Yellow Removed from study 0-14 21-56 49-70 70 M VII 646405 General observation, No Abnormality Detected Discharge, Mouth, Clear Stain Fur/Skin, Face, Red Removed from study 0-14,35-63 21-28 70 70 M VII 646418 General observation. No Abnormality Detected Removed from study 0-70 70 M VII 646362 General observation, No Abnormality Detected Discharge, Penis, Red Hair Loss, Abdomen, Medial Hair Loss, Base of tail Hair Loss, Forelimb, Bilateral Hair Loss, Perineum Removed from study 0-35 49 63-70 42-70 70 49-70 70 Company Sanitized. Does not contain TSCA CBI -582- )) H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646497 General observation, No Abnormality Detected 0,14-28 Discharge, Mouth, Clear 7 Hair Loss, Forepaw, Left 49-70 Stain Fur/Skin, Perineum, Yellow 35-70 Stain Fur/Skin, Face, Red 56 Removed from study 70 i M VII 646401 General observation, No Abnormality Detected Discharge, Mouth, Clear Hair Loss, Hindpaw, Left Wound, Superficial, Mouth Stain Fur/Skin, Perineum, Yellow Removed from study 0-14,28-35,63 42-49 49 21 49-56,70 70 M VII 646422 General observation. No Abnormality Detected Hair Loss, Ventral body. Bilateral Swollen Observations, Abdomen Wet Fur, Chin Sacrificed in extremis 0 7-28 28 21-28 28 M VII 646498 General observation. No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-56 63-70 70 M VII 646386 General observation, No Abnormality Detected Hair Loss, Abdomen, Bilateral Hair Loss, Lumbar, Right Hair Loss, Side, Bilateral Hair Loss, Thoracic, Ventral Stain Fur/Skin, Perineum, Yellow Removed from study 0-28 63-70 35-56 49-70 49-56 56-70 70 M VII 646332 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -583- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations } DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646441 General observation. No Abnormality Detected Breathing Observations, Labored Removed from study 0-56,70 63 70 M VII 646452 General observation, No Abnormality Detected Removed from study 0-70 70 M VII 646365 General observation, No Abnormality Detected Misshapen Observations, Ear, Right Stain Fur/Skin, Perineum, Yellow Removed from study 0 7-70 35-70 70 M VII 646393 General observation, No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-42,56-63 49,70 70 M VII 646359 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Wet Fur, Chin Removed from study 0-14,28-42 49-70 56-70 21 70 M VII 646380 General observation. No Abnormality Detected Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Chin, Brown Found dead in cage. 0-14,28 30-31 21 31 M VII 646451 General observation, No Abnormality Detected Removed from study 0-70 70 M VII 646364 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0,35-42,77,98-123 123 7-28,49-70,84,91 85 84 123 Company Sanitized. Does not contain TSCA CBI -584- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646384 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Neck, Ventral Wound, Superficial, Forelimb, Right Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-56 123 85 112-123 70-84,91-105,119-123 77-84,91-98 84,91 63-84,91-105 123 M VII 646474 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-14,35-77,98-123 123 21-28 85 84,91 123 M VII 646448 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Sacrificed by design 0,35-84,91-123 123 7-28 85 123 M VII 646484 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Discharge, Mouth, Clear Discharge, Eye left, Black No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Right Carriage, Low Misshapen Observations, Ear, Left Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Brown Sacrificed by design 0-7 123 118-123 28 112-119 85 49 112-123 28-84,91-123 35-84,91-119 14-21 123 Company Sanitized. Does not contain TSCA CBI -585- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days M VII 646337 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Medial Hair Loss, Forepaw, Bilateral Hair Loss, Perineum Hair Loss, Side, Left Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Sacrificed by design 0,112-123 123 85 7-28 70 7-28 28-84,91-105 49 70-84,91 123 M VII 646428 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Perineum Urine, Present, Clear Sacrificed by design 0,28,42-84,91,112-123 123 35 85 7-21 98-105 123 M VII 646369 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Shoulder, Right Wound, Superficial, Shoulder, Left Wound, Superficial, Shoulder, Right Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0,123 123 85 35-42 7-14 21-28 49-84,91-119 123 M VII 646397 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-56,77-84,91-123 123 85 63-70 123 M VII 646372 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Lethargic Discharge, Mouth, Red No Ophthalmological Abnormalities Detected Stain Fur/Skin, Chin, Brown Sacrificed by design 0-7,21,28-84,91-123 123 22 22 85 14 123 Company Sanitized. Does not contain TSCA CBI -586- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 646592 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F II 646560 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 0-35,42-84,91 40,96 85 95-96 96 F II 646676 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F II 646665 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Face, Red Sacrificed by design o F II 646612 General observation. No Abnormality Detected o Eye Observations, Bled via Orbital for Clin Path, Left 3*D No Ophthalmological Abnormalities Detected 0) Hair Loss, Forepaw, Bilateral (fi3 < Sacrificed by design (s0fi) 3 F II 646538 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left N No Ophthalmological Abnormalities Detected a Sacrificed by design D F II 646659 General observation, No Abnormality Detected 0 <T> Eye Observations, Bled via Orbital for Clin Path, Left w No Ophthalmological Abnormalities Detected 3 !0- Sacrificed by design o o F II 646649 General observation. No Abnormality Detected f3f Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected 5* Hair Loss, Dorsal Body, Medial oH CO Sacrificed by design oo>o 0-28 40,96 85 70-84,91-96 35,42-84,91-95 96 0-14,49-84,91-96 40,96 85 21-35,42 96 0-35,42-84,91-96 40,96 85 96 0-35,42-84,91-96 40,96 85 96 0-35,42,63-84,91-96 40,96 85 49-56 96 >) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 646617 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F II 646537 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F II 646642 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Nose, Black Accidentally killed, died after bleed 0,7,28,35-49,56-70,77-84 0,3,21,34,89 9,55,76 14-21 89 F II 646530 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Base of tail Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Sacrificed by design 0,7,14 0,3,21,34,89,93,109,116,126,140,161 9,55,76,97,102,183 49,56-70,77-84,91,98,105,112,119-183 21-28,35-49,56-70,77-84,91,98, 105.112.119- 183 98.105.112.119- 183 183 F II 646588 General observation. No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Discharge, Eye right. Brown Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-140 175-183 55,126,161 0,3,21,34,89,93,109,116,140,183 9,76,97,102 175-183 147-182 183 F II 646597 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-183 55 0,3,21,34,89,93,102,109,116,126,140,161 9,76,97,183 183 Company Sanitized. Does not contain TSCA CBI - 588- )) H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 646507 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Left Sacrificed by design 0,7,14-28,35-49,56-70,77-84 112.119- 183 91,98,105 112.119- 183 140 0,3,21,34,89,116 9,55,76,93,97,102,109,126,161,183 105.112.119- 183 91,98 183 F II 646653 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646575 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646585 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Stain Fur/Skin, Face, Red Removed from study 0-7 42-70 14-35 63-70 70 F II 646622 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-42 49-70 70 F II 646550 General observation, No Abnormality Detected Hair Loss, Neck, Ventral Removed from study 0-14,35 21-28 70 F II 646526 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646503 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646644 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646604 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -589- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 646651 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646552 General observation. No Abnormality Detected Removed from study 0-70 70 F II 646606 General observation, No Abnormality Detected Hair Loss, Forelimb, Left Removed from study 0-42 49-70 70 F II 646557 General observation. No Abnormality Detected Removed from study 0-70 70 F II 646591 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646544 General observation. No Abnormality Detected Removed from study 0-70 70 F II 646646 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646520 General observation. No Abnormality Detected Removed from study 0-70 70 F II 646569 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646654 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646668 General observation, No Abnormality Detected Removed from study 0-70 70 F II 646580 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Ventral Hair Loss, Forepaw, Bilateral Sacrificed by design 0-14,98-124 124 85 56-70 21-84,91 124 Company Sanitized. Does not contain TSCA CBI -590- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 646581 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646627 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646565 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646551 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646511 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646549 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91.-124 124 85 124 F II 646652 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646586 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F II 646613 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Wound, Superficial, Forepaw, Bilateral Sacrificed by design 0-14 124 85 84,91-124 49-77 28-84,91-124 21 124 Company Sanitized. Does not contain TSCA CBI -591- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV 646522 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646660 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646502 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646595 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design Left 0-28 40,96 85 49-84,91-96 35,42-84,91-96 96 F IV 646567 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design 0-35,42 40,96 85 49-84,91-96 49-84,91-96 96 F IV 646673 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Hyperactive No Ophthalmological Abnormalities Detected Hair Loss, Dorsal Body, Medial Hair Loss, Forepaw, Bilateral Abnormal Gait, Hindlimb,.Bilateral Stain Fur/Skin, Face, Red Sacrificed by design 0-7 40,96 56-84,91 85 49-84,91-95 28-35,42-84,91-96 35,42-84,91 14-35,42-84,91-96 96 Company Sanitized. Does not contain TSCA CBI -592- ) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV 646635 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Dorsal Body, Medial Sacrificed by design 0-35,42,84,91-96 40,96 85 49-77 96 F IV 646664 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646621 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646576 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F IV 646625 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-147,161-183 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161,183 154 183 F IV 646568 General observation. No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left Discharge, Eye right. Black Discharge, Eye right, Red Hair Loss, Forepaw, Bilateral Wound, Superficial, Forepaw, Left Sacrificed by design 0,7 56-63 91.98.105.112.119-183 0,3,21,34,89,126,140,161 9,55,76,93,97,102,109,116,183 91.98.105.112.119-183 49,56-70,77-84,98,105,112 14 28,35-49,56-70,77-84,91,98 21 183 Company Sanitized. Does not contain TSCA CBI -593- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV 646626 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-140 154-183 0,3,21,34,89,93,109,116,126,140,161 9,55,76,97,102,183 147-183 183 F IV 646531 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Misshapen Observations, Tail Sacrificed by design 0,7,14-28,35-49,56-70,77 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161,183 84,91,98,105,112,119-183 183 F IV 646636 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Stain Fur/Skin, Shoulder, Bilateral, Brown Stain Fur/Skin, Shoulder, Bilateral, Yellow Sacrificed by design 0,7,14-28,35-49,112,119 9,55 0,3,21,34,89,93,109,116,126,140 76,97,102,161,183 56-70,77-84,91,98,105,126-140,183 147-182 183 F IV 646638 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646559 General observation, NO Abnormality Detected Removed from study 0-70 70 F IV 646598 General observation. No Abnormality Detected Removed from study 0-70 70 F IV 646561 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646573 General observation. No Abnormality Detected Removed from study 0-70 70 F IV 646504 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-42 49-70 70 F IV 646587 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -594- ) H90--2D47ay68G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV 646631 General observation. No Abnormality Detected Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Removed from study 0-42 49-70 49-70 70 F IV 646529 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646603 General observation. No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-14 21-70 70 F IV 646554 General observation. No Abnormality Detected Removed from study 0-70 70 F IV 646579 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646564 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646672 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646584 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646543 General observation, No Abnormality Detected Removed from study 0-70 70 F IV 646596 General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Removed from study 0-7 35-70 14-28 49-70 70 F IV 646558 General observation. No Abnormality Detected Removed from study 0-70 70 F IV 646670 General observation. No Abnormality Detected Hair Loss, Forelimb, Bilateral Removed from study 0-14 21-70 70 F IV 646553 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Removed from study 0-42 49-70 70 Company Sanitized. Does not contain TSCA CBI -595- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 646608 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F VI 646556 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F VI 646629 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Sacrificed by design 0-35,42 40,96 85 49-84,91-96 96 F VI 646510 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F VI 646578 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 0-14,28-35,42 40,96 21 85 49-84,91-96 96 F VI 646505 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Dorsal Body, Medial Sacrificed by design 0-14,28-35,42,56-84,91-96 40,96 21 85 49 96 F VI 646534 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Sacrificed by design Left 0-14 40,96 85 21-35,42-84,91-96 96 Company Sanitized. Does not contain TSCA C8I -596- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 646624 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Dorsal Body, Medial Mass Perineum, Mass #1, Not Ulcerated, 0.50 cm Sacrificed by design 0-35,42,56 40,96 85 49 63-84,91-96 96 F VI 646501 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 40,96 85 96 F VI 646633 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 0-35,42-84,91-96 96 40 85 96 F VI 646656 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Sacrificed by design 0,7,14,28,35-42 0,3,21,34,55,89,93,109,126,140 9,76,97,102,116,161,183 21 49.56- 70,77-84,91,98,105,112,119-126 133-183 49.56- 70,77-84,91,98,105,112,119-183 183 F VI 646630 General observation. No Abnormality Detected Eye Observations, Bled via Orbital Eye Observations, Bled via Orbital Eye Observations, Bled via Orbital Discharge, Eye left, Black Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Wet Fur, Perineum Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 0,7,14-28,35-49,63-70,77-84,91, 98,112,119-140 183 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161 183 56 56,105,147-183 56 56,147 183 Company Sanitized. Does not contain TSCA CBI -597- )) H90--2D47ay68G: aSvaugbecbSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 646634 General observation, No Abnormality Detected Eye Observations, Opaque, Left Eye Observations, Bled via Orbital Eye Observations, Bled via Orbital Eye Observations, Bled via Orbital Discharge, Eye left, Black Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119-154 175-183 109 0,3,21,34,89,93,102,116,126,140 9,55,76,97,161,183 161-183 183 F VI 646533 General observation. No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Hair Loss, Base of tail Hair Loss, Dorsal Body, Medial Hair Loss, Forelinib, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Accidentally killed, died at bleed 0,7,14-21 93,183 0,3,21,34,89,102,116,126,140 9,55,76,97,109,161 147-183 49 28,35-49,56-70,77-84,91,98,105,112, 119-183 161-183 119-154 183 F VI 646632 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Dorsal Body, Medial Sacrificed by design 0,7,14-28,35-42,56-70,77-84,91, 98,105,112,119-183 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161,183 49 183 F VI 646547 General observation, No Abnormality Detected Hair Loss, Dorsal Body, Medial Removed from study 0-42,56-70 49 70 F VI 646666 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646607 General observation, No Abnormality Detected Hyperreactive Removed from study 0-7,21-70 14 70 F VI 646524 General observation, No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-56,70 63 70 Company Sanitized. Does not contain TSCA CBI -598- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 646600 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646648 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646594 General observation, No Abnormality Detected Hair Loss, Dorsal Body, Medial Removed from study 0-42,56-70 49 70 F VI 646546 General observation. No Abnormality Detected Hair Loss, Abdomen, Medial Hair Loss, Dorsal Body, Medial Removed from study 0 7-70 49 70 F VI 646661 General observation, No Abnormality Detected Hair Loss, Dorsal Body, Medial Removed from study 0-42,56-70 49 70 F VI 646671 General observation. No Abnormality Detected Hair Loss, Forelimb, Right Removed from study 0-42,70 49-63 70 F VI 646521 General observation, No Abnormality Detected Hair Loss, Hindlimb, Bilateral Removed from study 0-63 70 70 F VI 646590 General observation. No Abnormality Detected Removed from study 0-70 70 F VI 646645 General observation, No Abnormality Detected Hair Loss, Dorsal Body, Medial Removed from study 0-42,56-70 49 70 F VI 646555 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646605 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646589 General observation, No Abnormality Detected Hair Loss, Abdomen, Medial Hair Loss, Forelimb, Bilateral Removed from study 0-21 63 28-70 70 Company Sanitized. Does not contain TSCA CBI -599- )) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 646615 General observation, No Abnormality Detected Stain Fur/Skin, Chin, Brown Removed from study 0-14,28-70 21 70 F VI 646527 General observation. No Abnormality Detected Hair Loss, Forelimb, Bilateral Removed from study 0-42,56-70 49 70 F VI 646647 General observation, No Abnormality Detected Removed from study 0-70 70 F VI 646675 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA C8I -600- )) H90--2D47a6y8G: aSvaugbechSrtoundiyc iTnoRxiactistywith On-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646657 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Brown Sacrificed by design 0-35,42-49 40,96 85 56-84,91-96 96 F Vili 646610 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Hyperreactive Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Face, Red Retina, Retinal Degeneration Focal, Left Sacrificed by design 0-14 40,96 91 35,42-84,91-96 21-28 49-84,91-96 56-84,91-96 85 96 F Vili 646536 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-14 40,96 85 49-84,91-96 49-84,91-96 21-35,42 56-84,91-96 96 F Vili 646593 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Hindlimb, Bilateral Hair Loss, Side, Bilateral Hair Loss, Side, Right Sacrificed by design 0-21 40,96 85 49-84,91-96 63-84,91-96 28-35,42-56 96 Company Sanitized. Does not contain TSCA CBI -601- ) H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646509 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Bilateral Hair Loss, Abdomen, Right Hair Loss, Base of tail Hair Loss, Forepaw, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Side, Right Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-7 40,96 14-28 85 21-35,42-84,91-96 14 56-84,91-96 63-84,91-96 14-35,42-84,91-96 49-84,91-96 42 42,63-84,91-96 96 F VIII 646669 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Right Hair Loss, Base of tail Hair Loss, Hindlimb, Bilateral Hair Loss, Sacral, Dorsal Hair Loss, Side, Right Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Red Sacrificed by design 0-7 40,96 85 63-84,91-96 14-35,42-84,91-96 63-84,91-96 35.42- 56 49-84,91-96 35.42- 84,91-96 14-35,42-84,91-96 63-70 96 F VIII 646614 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Wet Fur, Perineum Sacrificed by design 0-35,42-56 40,96 85 63-84,91-96 96 96 F VIII 646609 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-7 40,96 85 14-35,42-84,91-96 28-35,42-84,91-96 56-84,91-96 96 Company Sanitized. Does not contain TSCA CBI -602- )) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646577 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Hyperactive No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Medial Hair Loss, Forelimb, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Lumbar, Dorsal Hair Loss, Lumbar, Medial Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Hair Loss, Thoracic, Ventral Hair Loss, Ventral body, Ventral Wound, Superficial, Lumbar Stain Fur/Skin, Perineum, Yellow Sacrificed by design Left 0-28 40.96 91 85 35.42- 49,91 63-84,95-96 63-84,91-96 91 96 35.42- 56,91,96 91.96 35.42- 56 56-84,95-96 91 91-96 96 VIII 646535 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Medial Hair Loss, Forelimb, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Lumbar, Dorsal Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Hair Loss, Side, Left Hair Loss, Side, Right Hair Loss, Ventral body, Ventral Wound, Superficial, Lumbar Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0 40.96 85 7-35,42-84,95 91.96 14-35,42-84,91-96 95 95 14-35,63-84,95 42-56 7 91.96 95 63-84,95-96 96 F VIII 646667 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Stain Fur/Skin, Perineum, Red Swollen Observations, Forepaw, Left Sacrificed by design 0,21-28,35-49,91,98,105,112,119-183 0,3,21,34,89,93,109,116,126,140 9,55,76,97,102,161,183 7,14 56-70,77-84 183 Company Sanitized. Does not contain TSCA CBI -603- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F Vili 646523 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Hair Loss, abdomen, Medial Hair Loss, Base of tail Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Hair Loss, Forepaw, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Hair Loss, Side, Right Hair Loss, Ventral body. Ventral Sacrificed by design 0 147-183 105.112.119- 140 183 0,3,21,34,89,93,109,116,140,161 9,55,76,97,102,126 105.112.119- 183 14-28,35-49,56-63 35-49,56-70,77-84,91,98,105 140-183 133 133-183 42-49,56-70,77-84,91,98,105,112, 119-133 56-70,77-84,91 14-28,35-49,56-70,77-84,91,98, 105 7 63-70,77-84,91,98,105 183 F VIII 646528 General observation. No Abnormality Detected Eye Observations, Opaque, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Head, Left Stain Fur/Skin, Abdomen, Yellow Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Inguen, yellow Stain Fur/Skin, Perineum, Yellow Wet Fur, Inguen, Bilateral Wet Fur, Perineum Sacrificed by design 0,7,14-28 133-183 34 0,3,21,89,93,109,116,126,140 9,55,76,97,102,161,183 140-161 35-49 49 91,98,105,112,119-140 49,56-70,77-84,91,98,105,112,119-140 91 91 183 F VIII 646601 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Perineum, Yellow Accidentally killed, died at bleed 0,7,14-28,35,49,147-183 21 0,3,34,89,93,109,116,126,140 9,55,76,97,102,161,183 42 42,56-70,77-84,91,98,105,112,119-140 183 Company Sanitized. Does not contain TSCA CBI -604- )> H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days VIII 646620 General observation, No Abnormality Detected Eye Observations, Bled viaOrbital for Clin Path, Bilateral Eye Observations, Bled viaOrbital for Clin Path, Left Eye Observations, Bled viaOrbital for Clin Path, Right Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Stain Fur/Skin, Neck, Red Sacrificed by design 0,7,14-28,35-42,119-183 93,161 0,3,9,21,34,89,109,116,126,140 55,76,97,102,183 49,56-70,77-84,91 91.98.105.112 91.98.105.112 183 VIII 646662 General observation, No Abnormality Detected Discharge, Mouth, Clear Swollen Observations, Toe, Forepaw Left Removed from study 0-14,28-49,63-70 21 56 70 VIII 646583 General observation. No Abnormality Detected Stain Fur/Skin, Face, Brown Removed from study 0-28,56-70 35-49 70 VIII 646623 General observation, No Abnormality Detected Discharge, Mouth, Clear Stain Fur/Skin, Chin, Pink Removed from study 0-14,28-70 21-26 26 70 VIII 646619 General observation, No Abnormality Detected Hair Loss, Hindlimb, Left Removed from study 0-7,42-70 14-35 70 VIII 646539 General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral Stain Fur/Skin, Perineum, Yellow Removed from study 0-42 49-70 63 70 VIII 646628 General observation, No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-49 56-70 70 VIII 646616 General observation, No Abnormality Detected Removed from study 0-70 70 VIII 646563 General observation, No Abnormality Detected Removed from study 0-70 70 Company Sanitized. Does not contain TSCA CBI -605- H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL CLINICAL AN D OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646641 General observation, No Abnormality Detected Stain Fur/Skin, Perineum, Yellow Removed from study 0-49 56-70 70 F VIII 646572 General observation. No Abnormality Detected Hair Loss, Abdomen, Left Hair Loss, Hindlimb, Bilateral Hair Loss, Side, Bilateral Hair Loss, Ventral body, Bilateral Wound, Superficial, Hindlimb, Left Removed from study 0-7 14 63-70 14-70 21-70 21 70 F VIII 646512 General observation. No Abnormality Detected Hair Loss, Hindlimb, Bilateral Hair Loss, Sacral, Bilateral Hair Loss, Side, Left Stain Fur/Skin, Perineum, Yellow Wet Fur, Perineum Removed from study 0-7 49-70 14-70 35-70 14-28 14 70 F VIII 646566 General observation, No Abnormality Detected Removed from study 0-70 70 o F VIII 646570 General observation, No Abnormality Detected 330 *o Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Perineum, Yellow fi) Removed from study 3 < CO F VIII 646602 General observation, No Abnormality Detected f3i) Discharge, Mouth, Clear r*> Hair Loss, Abdomen, Medial N Hair Loss, Perineum (0 Q. Hair Loss, Sacral, Dorsal Hair Loss, Side, Right O Stain Fur/Skin, Perineum, Yellow 0 <D Stain Fur/Skin, Face, Brown (A Removed from study 3 0 r+ F VIII 646582 General observation, No Abnormality Detected O o Stain Fur/Skin, Inguen, Yellow 3 Stain Fur/Skin, Perineum, Yellow ST Removed from study w H CO oO > OD 0-49 63-70 56-70 70 0-7 56 14-70 21-70 35-70 14-70 42-70 56 70 0-28 56-70 35-70 70 H90--2D47ay68G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646655 General observation. No Abnormality Detected Hair Loss, Forepaw, Right Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Red Removed from study 0-7,35-56 63-70 14-21 28 21 70 F VIII 646663 General observation, No Abnormality Detected Removed from study 0-70 70 F VIII 646640 General observation, No Abnormality Detected Hair Loss, Side, Right Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Perineum, Yellow Removed from study 0-7,28-35 14-21 42-70 42-70 70 F VIII 646574 General observation. No Abnormality Detected Hair Loss, Dorsal Body, Medial Hair Loss, Forepaw, Bilateral Removed from study 0-42,56-70 49 49 70 F VIII 646532 General observation, No Abnormality Detected Hair Loss, Abdomen, Ventral Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Right Hair Loss, Forepaw, Bilateral Hair Loss, Side, Bilateral Hair Loss, Ventral body, Bilateral Removed from study 0 7-14 28-70 14 28-70 7-70 21-70 70 F VIII 646540 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Abdomen, Ventral Hair Loss, Forelimb, Right Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Hair Loss, Ventral body, Bilateral Sacrificed by design 0 124 85 7-14 49-84,91 42-84,91-124 7-84,91-124 21-84,91-124 124 Company Sanitized. Does not contain TSCA CBI -607- ) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646548 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-7,35-42,56,98-124 124 85 63-84,91 14-28 49 124 F VIII 646508 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Red Sacrificed by design 0-42 124 63 85 49-84,91-124 63-84 124 F VIII 646650 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Face, Red Sacrificed by design 0-56 124 85 119-124 63-84,91-119 70-84,91-105 124 F VIII 646637 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 F VIII 646545 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Hindlimb, Bilateral Hair Loss, Sacral, Dorsal Hair Loss, Side, Bilateral Hair Loss, Thoracic, Ventral Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-28 124 85 35-84,91-124 91-105 70-84,91-124 35-84,91-105 77-84,91-119 124 Company Sanitized. Does not contain TSCA CBI -608- >) H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) DuPont-5990 INDIVIDUAL CLINICAL AND OPHTHALMOLOGCAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VIII 646618 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Stain Fur/Skin, Chin, Brown Sacrificed by design 0-14,28-84,91-124 124 85 21 124 F Vili 646506 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Stain Fur/Skin, Perineum, Yellow Sacrificed by design 0-84,124 124 85 91-119 124 F Vili 646542 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hyperactive Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Stain Fur/Skin, Abdomen, Yellow Stain Fur/Skin, Perineum, Yellow Stain Fur/Skin, Chin, Brown Sacrificed by design 0-14,28-84 124 105-124 21 85 91-112 119-124 21 124 F Vili 646599 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-84,91-124 124 85 124 Company Sanitized. Does not contain TSCA CBI -609- H90--2D47ay68G: aSvuabgcehSrotundicyTwoixthicOityne-Generation Reproduction Evaluations DuPont-5990 APPENDIX F OPHTHALMOLOGICAL EXAMINATION REPORT -610Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 9Q-Day Gavage Study with One-Generation Reproduction Evaluations DuPont-5990 NANCY M. BROMBERG, VJVf.D., M.S. EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE BETHESDA, MD 20816 STUDY INFORMATION! SSptuedciyesN:oR. at Study Director: SUE MACKENZIE OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: Jone 8,2001 Test Day: 85 MSeEx THODS: AAInnndimiimraeacl tl##OphthalmosOcOobbpssyeerrfvovalaltotiiowonning 1% Tropicaiaide mydriasis Mate 664466442266 FFooccaallrreettiinnaallddeeggeenneerraattiioonnOODD 646475 Phthisical globe OS Female 664466641103 Focal retinal degeneration OD Focal retinal degeneration OS C O M M E N TS/D ISC U SSIO N Four (4) animals were identified with ophthalmoscopic lesions, three (3) males and one (1) lemale. orbit duIrnintwg oleoftfothrbeictaalsseisn,uths ebalebendoinrgm. aTlithieesfocacnalbaereaatstroibfudteegdentoertartaiuonmsaeetontihnethgleobotehaenrdtw/oor animalsNios ccoonmspidoeurnedd rinelcaotnedseaqbuneonrtmialalities were identified. Diplomate, A.C.V.O. -611Company Sanitized. Does not contain TSCA CBI