Document baRG5pYnb6JxL2LdLm0ZyMbNO

, 3M Environm ental Technology and Services / f May 10, 2002 PO Box 33331 St. Paul, M N 55133-3331 651 778 6442 X i JI ' M - S " 1 i4 R 4 U _ I M S ' RECEIVED OPPT CBIC 2062JUN-U M l h 10 Document Processing Center (7407) Office of Pollution Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue NW Washington, D.C. 20460 f Y l - O b -0 2 -.0 1 3 7 8 Attention: For Your Information Docket - Docket No. AR-226 Re: Information on Perfluorooctane Sulfonates and Related Compounds Dear Sir or Madam: This continues 3M's voluntary submissions of data on perfluorooctane sulfonates and related compounds, as part of our ongoing dialogue with EPA regarding fluorochemicals. Enclosed you will find the following supplement to the Two-Generation Reproduction Study of Ammonium Perfluorooctanoate in Rats submitted previously to the docket on April 2, 2002: Final Report, Protocol 418-020, Argus Research, Charles River Laboratories, May 1, 2002. fess) KJ c_ caezr _ o O 30 -v rn --im~ X 3 c ~ ) ~Q q mo The enclosed document describes in detail the covariance data from the two-generation reproduction/developmental study with ammonium perfluorooctanoate. This analysis was undertaken in an attempt to understand the degree to which certain effects seen in the FI generation (delayed sexual maturation, post-lactational mortality, and increased estrous cycles) could be explained by either gestational age/maturity or body weight of the animals. oo We will continue to provide information as it becomes available. Please feel free to contact me with any questions. Very truly yours, FYI-00-001378 6 .S Michael A. Santoro Director of Environmental, Health Safety and Regulatory Affairs Specialty Materials Markets 3M Center, Building 236-1B-10 St. Paul, MN 55144 651-733-6374 (phone) 651-733-1958 (fax) E-mail: masantoro@mmm.com FYI-0 0 -0 0 1 3 7 8 CONTAIN N O C f Enc. cc: Dr. Charles Auer Dr. Oscar Hernandez 1 85020000010 B5020000010