Document bBbnQZ1OM8jKJjYoaq7qZ0m2k

From: Broddle, Bill D. [Bill. D. Broddle@conoco. com] Sent: Thursday, November 14, 2002 9:51 AM To: Clegg, Patsy M SCC-CHSE-PC Subject: RE: Benzene Health Research Consortium/Benzene Project; ConocoPhillips' Financial Support Patsy, our Downstream HS&E manager plus the Downstream Vice-President met two-weeks ago and they are presently not in favor of increased financial support from ConocoPhillips for the BHRC project. But they do want to provide personnel support for the science and sustainable development activities so I am meeting on Nov. 25 with the Downstream HS&E mgr and the corporate HS&E v.p. to discuss this stance. I will know more by the time we all meet in D.C. on Dec. 11. which I believe is the date we next meet as a group. William D. Broddle, Ph.D. Sr. Toxicologist Marland Bldg, 1034 Houston/281-293-4252 Fax: 281-293-4414 (or 2774) Cell: 281-787-2609 Email: bill.d.broddle@conoco.com -----Original Message----From: Clegg, Patsy M SCC-CHSE-PC [mailto:pmclegg@Shell.Com] Sent: Tuesday, November 05, 2002 2:50 PM To: Broddle, Bill D. Cc: Burnett, Don (E-mail); Beatty, Pat (E-mail); Carol Fairbrother (E-mail); Matthew Todd (E-mail); Lynn Russo (E-mail) Subject: RE: Benzene Health Research Consortium/Benzene Project; ConocoPhillips' Financial Support Bill, Thanks for this update. Sounds like you made good progress. My suggestion to the OC/Recruitment is to put your suggestions on the agenda for the Dec meeting. Perhaps you could bring some ideas on how to frame an SD objective. Patsy -----Original Message----From: Broddle, Bill D. [mailto:Bill.D.Broddle@conoco.com] Sent: Tuesday, November 05, 2002 1:43 PM To: Beatty, Patrick (PatrickBeatty); Burnett, Donald M.; Clegg, SCC-CHSE-PC Cc: Lorraine Twerdok; Johnston, Michael D.; Galvin, Jennifer B; Robert A; Parker, Dennis R. Subject: Benzene Health Research Consortium/Benzene Project; ConocoPhillips' Financial Support Patsy M Ridge, I held a meeting to discuss the above topic; attendees included Bob Ridge (v.p. Corporate HS&E), Dennis Parker (former v.p. of Corporate HS&E who has elected to retire), Mike Johnston (Mgr., Downstream HS&E), Jennifer Galvin (Mgr., I.H. and Toxicology), and myself. In general, the consensus of the group was favorable towards increasing hConoco's financial support of SH ELL-MCCLU RG-067704 the project, but there were several issues that this group thought needed high priority before they would formally consider increasing our financial support: -The goal of the Study should FIRST stress product stewardship so as to better minimize the potential health hazards of benzene throughout the world, both for industry and the general public. SECONDLY, an important goal of the Study should be to strengthen our knowledge of how best for the Study to enhance sustainable development for benzene-containing products so corporate economics and social issues are adequately addressed. This latter point should be more thorough in convincing corporations to financially support the Study. -Communications Committee: This Committee should promote the above product stewardship and sustainable development issues as being primary goals of the Study, especially that of improving protection and understanding of potential benzene health hazards for global workers and the general public. Corporate professionals in the area of sustainable development would be a useful resource. -Ethics Review Panel Members: This Panel must quickly expand to include the European representative and also the non-voting member that represents Chinese workers. I met with Mike Johnston on October 14 and discussed how best to include this topic during his October 15 meeting with our Executive v.p. of Downstream, Jim Nokes. Patsy Clegg, Shell Chemical, has also offered to come visit our Houston offices and give her perspective of the project, so I will discuss this with Bob Ridge and Mike Johnston. William D. Broddle, Ph.D. Director, Toxicology & Product Safety Ponca Bldg, 2046 Houston/281-293-4252 Fax: 281-293-4394 Cell: 281-787-2609 Email: bill.d.broddle@usa.conoco.com SH ELL-MCCLU RG-067705 Shanghai Benzene Health Consortium Sponsor Recruitment Planning September 13, 2002 8:30 - 3:30 Agenda I. Welcome and Introductions - Patsy - Facility Familiarization - AntitrustlLegal Advice - Mark Fitzsimmons - Update from Howard Feldman, API - Expectations, Issues, Challenges - Meeting Objectives/Agenda Review 8:30-9:30 II. Consortium Structure for Recruitment (Attachment 1 & 2 - Draft) - Patsy 9:30-10:00 III. Break-Don 10:00-10: 15 IV. Generate List of Sponsor Categories (Attachment 3 - Draft) - Pat Funding Philosophy/Schedule Generate List of Sponsor Categories - Generate List of Candidates for each category i. Candidates already contacted - status report ii. Candidates to be contacted - Prioritize Categories/Candidates 10: 15-11 :00 V. Recruitment Plan for Sponsor Categories - Don 11 :00-1 :00 - Category 1 Plan (i.e. API, Attachment 4 - Draft) w/ lunch - Category 2 Plan (i.e. Funding Company Sponsors, Attachment 5 - Draft) - Category 3 Plan - Category 4 Plan VI. Recruitment Materials - Lynn - Sponsor Candidates Contacts List - Consortium Company High Level Managers List - Letters of Introduction - Pre-meeting materials - Presentation Materials - Leave-Behinds - Follow-up materials - Internal Consortium Company Communication(s) - Press Releases - Q&As - Key Messages - Web Site - Others? 1:00-2:30 w/ break VII. Recruitment Project Time Line (suggest we use Microsoft Project) - Patsy 2:30-3:15 VIII. Path Forward - Patsy 3:15-3:30 SH ELL-MCCLU RG-067706 SH ELL-MCCLU RG-067707 A 1 BC D E Tier I Companies F 2 3 Lyondell-Equistar 4 Contacts 5 CEO 6 Product Manager 7 Technical 8 BHRC Member Lead 9 BHRC Member 10 11 Answer 12 13 14 DuPont Contacts 15 CEO 16 Product Manager 17 Technical 18 BHRC Member Lead 19 BHRC Member 20 21 Answer 22 23 24 Sunoco Contacts 25 CEO 26 Product Manager 27 Technical 28 BHRC Member Lead 29 BHRC Member 30 31 Answer 32 33 Name Deadline: Presentations Complete by 12/31/02 Lyondell-Equistar - Patsy Clegg Presentation Phone Email Date Comments Patsy Clegg Contact made with Claude White. Name Phone NO DuPont - Stu Cagen Presentation Email Date Comments Robin Leoadtepi Stu Cagen Lynn Russo Robin has followed up with Rob Schnatter of EMBSI. Name Phone Sunoco - Don Burnett Presentation Email Date Comments Deborah Donovan, HSE Manager 215-9776872 dadonovan@sunocoinc.com Don Burnett Presentation was made by Patrick Beatty and Don 12/5/2002 Burnett. Possible meeting with Sunoco representatives as early as Dec 3-5. Must have materials from CC to provide leave-behinds. NO Marathon - Patrick Beatty 8 SH ELL-MCCLU RG-067708 AB 34 Marathon Contacts 35 CEO 36 Product Manager 37 Technical 38 BHRC Member Lead 39 BHRC Member 40 Name Patrick Beatty 41 Answer 42 43 44 Sinopec Contacts 45 CEO 46 Product Manager 47 Technical Name 48 BHRC Member Lead 49 BHRC Member 50 51 Answer 52 53 Lynn Russo Bill Frick 54 PetroChina Contacts Name 55 CEO 56 Product Manager 57 Technical WiliiamWu 58 BHRC Member Lead 59 BHRC Member 60 61 Answer Lynn Russo Stu Cagen C Phone D Email E Presentation Date F Comments Marathon has indicated that they will contribute $200K. Phone Sinopec - Lynn Russo Presentation Email Date Comments Given Sinopec US staffing, contact in the US is ineffective. Pursuing briefing by Pis in China to describe project; anticipate company representative(s) would follow-up on funding/participation. PetroChina - Lynn Russo Presentation Phone Email Date Comments Shan Tsai will pursue participation in March, 2003 CAPA Symposium. Stu Cagen to make contact call to Houston Office 8 SH ELL-MCCLU RG-067709 A 1 B CD E Tier II Companies F 2 3 4 Solutia Contacts 5 CEO 6 Product Manager 7 Technical 8 BHRC Member Lead 9 BHRC Member 10 11 12 13 Name Judy Elledge 14 Petronas Contacts 15 CEO 16 Product Manager 17 Technical 18 BHRC Member Lead 19 BHRC Member 20 21 22 23 Name Lynn Russo 24 BASF Contacts 25 CEO 26 Product Manager 27 Technical 28 BHRC Member Lead 29 BHRC Member 30 31 32 Name Gerhard Gans Stu Cagen Shannon Stewart 33 Petro-Canada Contacts Name 34 CEO 35 Product Manager 36 Technical 37 BHRC Member Lead Lynn Russo Deadline: Presentations Complete by 3/31/02 Solutia - Judy Elledge Presentation Phone Email Date Comments Petronas - Lynn Russo Presentation Phone Email Date Comments BASF - Stu Cagen Presentation Phone Email Date Comments Reply from Dr. Gans stating "There are no resources available to follow up or support the project in Shanghai." Stu has left voicemail, sent emails. No reply to date. Petro-Canada - Lynn Russo Presentation Phone Email Date Comments 8 SHELL-MCCLURG-067710 A 38 BHRC Member 39 40 41 B 42 CITGO Contacts 43 CEO 44 Product Manager 45 Technical 46 PDVSA Contacts 47 CEO 48 Product Manager 49 Technical 50 BHRC Member Lead 51 BHRC Member 52 53 54 55 Chevron Phillips 56 Contacts 57 CEO 58 Product Manager 59 Technical 60 BHRC Member Lead 61 BHRC Member Name Brian Turner Name Stu Cagen Name Patrick Beatty CD E F CITGO/PDVSA - Stu Cagen Presentation Phone Email Date Comments Phone Email Stu to send DOW presentation to Brian Turner in Oklahoma office. Presentation Date Comments Chevron Phillips - Patrick Beatty Presentation Phone Email Date Comments 8 SHELL-MCCLURG-067711 A B CD E F 1 Tier III Companies 2 Contact Information Complete by 12/31/02 3 Yukos - Shannon Stewart 4 Yukos Contacts 5 CEO 6 Product Manager 7 Technical 8 BHRC Member Lead 9 BHRC Member 10 11 12 Name Shannon Stewart Presentation Phone Email Date 13 PEMEX - Patsy Clegg 14 PEMEX Contacts 15 CEO 16 Product Manager 17 Technical 18 BHRC Member Lead 19 BHRC Member 20 21 22 Name Patsy Clegg Presentation Phone Email Date 23 Bayer - Judy Elledge 24 Bayer Contacts 25 CEO 26 Product Manager 27 Technical 28 BHRC Member Lead 29 BHRC Member 30 31 Name Judy Elledge Presentation Phone Email Date 32 Statoil - Don Burnett 33 5tatoil Contacts 34 CEO 35 Product Manager 36 Technical 37 BHRC Member Lead 38 BHRC Member Name Don Burnett Presentation Phone Email Date Comments Comments Comments Comments 8 SHELL-MCCLURG-067712 A 39 40 B CD E 41 TotalFinaElf - Don Burnett 42 TotalFinaElf Contacts 43 CEO 44 Product Manager 45 Technical 46 BHRC Member Lead 47 BHRC Member 48 49 Answer 50 Name Don Burnett Presentation Phone Email Date 51 CNOOC - Patrick Beatty 52 CNOOC Contacts 53 CEO 54 Product Manager 55 Technical 56 BHRC Member Lead 57 BHRC Member Name Patrick Beatty Jay Stuller Presentation Phone Email Date F Comments NO Comments 8 SHELL-MCCLURG-067713 A BCD E F 1 < Full Share - Patron Companies 2 Contact Information Complete by 3 4 5 CEO 6 Product Manager 7 Technical 8 BHRC Member Lead 9 BHRC Member 10 11 12 13 14 15 CEO 16 Product Manager 17 Technical 18 BHRC Member Lead 19 BHRC Member 20 21 22 23 24 25 CEO 26 Product Manager 27 Technical 28 BHRC Member Lead 29 BHRC Member 30 31 32 33 34 CEO 35 Product Manager 36 Technical 37 BHRC Member Lead 38 BHRC Member Presentation Name Phone Email Date Comments Presentation Name Phone Email Date Comments Presentation Name Phone Email Date Comments Presentation Name Phone Email Date Comments 8 SHELL-MCCLURG-067714 A 39 40 41 42 43 CEO 44 Product Manager 45 Technical 46 BHRC Member Lead 47 BHRC Member 48 49 Answer 50 51 52 53 CEO 54 Product Manager 55 Technical 56 BHRC Member Lead 57 BHRC Member BCD E F Presentation Name Phone Email Date Comments NO Presentation Name Phone Email Date Comments 8 SHELL-MCCLURG-067715 Shanghai Benzene Health Consortium Candidate Sponsors Recruitment Org Chart API Companies Companies Government/ Societies NGOs Funding Non-funding Regulatory A2:encies H nnw r---- Marathon Ashland H Lyondell Sinopec Petrochina CNOOC Leukemia American Cancer H Petronaus '---- SHELL-MCCLURG-067716 SHANGHAI HEALTH STUDY Overview Purpose: To gain an accurate understanding of the relationship between benzene exposure and the risk of certain hematopoietic diseases. This study is an important element in the product stewardship programs of participating companies. It could also lead to improved, health-based regulatory (e.g., ambient air, water & occupational) standards worldwide, by providing the regulatory and scientific communities with additional information for more accurate assessment of the risks from exposure to benzene. A unique set of circumstances exists at this point in time in Shanghai to conduct benzene research. These include a database of occupational exposures, and qualified co-investigators influential in local scientific medical, and regulatory establishments. Therefore, questions that have complicated benzene health risk assessment for decades may be addressed in Shanghai. The Studies: The program involves three inter-related studies: Case-Control Study - A hospital-based case control study investigating the potential relationship between benzene exposure and both Non-Hodgkins Lymphoma (NHL) and Acute Myelogenous Leukemia (AML), including an attempt to quantify the potency of the AML response. Disease Progression Study - A hospital/clinic-based investigation of the potential relationship between non-cancer diseases of the bone marrow and AML to determine if effects on bone marrow progress through non-cancer stages to an ultimate leukemia. This study is also attempting to define the shape of the dose response for possible "precursor" diseases and could result in characterization of unique identifiers of benzene-induced AML. Molecular Epidemiology Study - Investigating if there is a quantitative relationship between benzene exposure and potential early indicators of both exposure and effect in a focused population of workers. The investigators are leading experts in their fields, coming from such well-known institutions as the University of Colorado Health Sciences Center and Fudan University Medical Center. The combined studies apply cutting-edge, 21 st century technologies in ways that will not only advance our understanding of benzene-induced disease, but may also identify potential prevention strategies for benzene-induced disease in individuals. Benefits: Information gained from this project may have direct relevance for worldwide regulatory standards designed to protect workers and the general population from benzeneinduced disease. These include air and water quality standards, as well as hazardous waste and site remediation standards. These studies will assist contributing companies in achieving the highest product stewardship goals and in oversight of their risk management programs. Challenges: The proposed studies meet several technical, ethical, and cultural/political challenges. Technical - In order to stand up to scientific scrutiny, studies must be large, well-managed, and incorporate the latest technology. State-of-the-art research is absolutely necessary to make real progress in developing sound benzene risk assessments. To that end, a Scientific Review Panel made up of leading experts from a number of fields relevant to these studies has reviewed and endorsed the research protocols. Additionally, the protocols have been reviewed by Use of Human Subjects Committees (lRB) both in the US and China. November 13, 2003 - 1- SHELL-MCCLURG-067717 SHANGHAI HEALTH STUDY Overview Ethical - To address ethical issues posed by the study, the protocols have undergone a thorough analysis to ensure that they meet international standards for research involving humans, including for example insuring that the subjects and the communities benefit from participating in the study; that confidentiality is preserved, and that participants are fully informed about the research to give their informed consent. An Ethics Panel is part of the oversight for the project. It includes bioethicists from the U.S., China and Europe. Cultural/Political- A key to this program's success is local partnerships. Collaborators on these studies include researchers from the Medical School at Fudan University, the Institute for Public Health Supervision, and the Shanghai Municipal Centers for Disease Control and Prevention (the latter two are governmental agencies responsible for occupational exposure monitoring and enforcement in Shanghai). Funding: Funding for the project is being provided by a consortium of interested oil and chemical companies. It is anticipated to take five years to complete the project, and that the costs are highest in the first years of the project. For More Information: Please contact anyone of the following individuals. Don Burnett, PhD Patrick Beatty, PhD Myron Harrison, MD Chris Roythorne, MD Lorraine Twerdok, PhD Bruce Jarnot, PhD BP ChevronTexaco ExxonMobil BP API API Q!!m~1tQm@lm_,~_Qm patrickbeatty(al,chevrontexaco.com myron. c.harrison@exxonmobil.com ~h!:i_~_,[QythQm~@_ll_k.Jm_,~_Qm twerdokl@aQi.org iarnotb(al,aoi.org 630-420-5093 510-242-7037 972-444-1673 44 (0)20 74964126 202-682-8344 202-682-8473 November 13, 2003 - 2- SHELL-MCCLURG-067718 Draft 5/26/04 BHRC Regulatory & Technical Outreach Plan US EPA- DC (Bill Farland, Peter Preuss, Bob Sonowane, Michael Brown) EU Environment DG Patrick & Stuart No Technical No Committee No Patrick Cal EPA German MAK Patrick No ? Health Canada (Betty Meeks) Patsy & Brian No OSHA ACGIH (Jim Pierce) Australia (info@nohsc.gov.au or info@nicnas.gov.au ) None Desi nated Stuart (on TLV com No No ? BHRC OC members Action Status Outcome/Comments Set up meeting with EPA contacts (probably in DC) 3004 Contact Jerry Rice for advice on how to contact Email Dr. Greim to determine what EU/Germany regulators are/should attend the October, 2004 International Benzene um in Munich Contact by phone or in person Anticipate attendance at International Benzene Symposium, where investigators will be presenting SHS information Contact Geoff Granville (Shell Canada) and Roger Keefe (Imperial Oil) for advice for contact Identify OSHA contact and schedule meeti ACGIH is not currently working on benzene; seek opportunity to inform as an FYI Pursue company contacts in Australia 4004 3004 4/004 or 1005 4004 3004 1/2005 2005 2004 Pending Pending Pending Pending Interested, but no money Completed Pending Pending Pending Pending Betty Meeks Need to identify BHRC lead Margaret Donnan @ PACIA ( Australian Plastics & Chemicals Industries Association) mdonnan@pacia.org.au Page 1 of 3 SHELL-MCCLURG-067719 Draft 5/26/04 BHRC Regulatory & Technical Outreach Plan Action Status Outcome/Comments NCI (Martha Linet) UKMRC (Michael Brown) US EPA (NCEA)RTP (George Woodall, La NIEHS (Mike Shelby) NIOSH - Cincinnati ? Technical Committee ? Patrick ? Stuart & Lynn (Myron Harrison to conta Myron Harrison ? Yes NCI will attend International Benzene Symposium (Hayes to Chair session); seek contact at that meetin Len Levy is on Benzene Symposium organizing committee, so initial contact has been made Contact George Woodall (phone call) to inform of SHS presentations at Benzene International ium Contact Mike to inform of SHS presentations at Benzene International Symposium Inform of SHS at next regularly scheduled call/meetin 4004 3004 3004 ?? Pending Completed Pending Stuart and Patrick to clarify organization(s) Pending Pending Myron needs to be contacted Hematology Society Patrick & Stuart Patrick & Stuart Patrick & Stuart No ? Yes Contact Dr. Larson for advice on how to a Contact Dr. for advice on how to a Contact Dr. for advice on how to a 3004 3004 3004 Pending Pending Pending Contact Dr. Larson at 2004 SHS Annual Meeti Contact Dr. Larson at 2004 SHS Annual Meeti Contact Dr. Larson at 2004 SHS Annual Meeti call/meeti Page 2 of 3 ?? Pending David Young, Aromatics business man in Eu SH ELL-MCCLU RG-067720 Draft 5/26/04 Organization (contact) IPIECA CONCAWE ACC Long Range Research Initiative BHRC Regulatory & Technical Outreach Plan BHRC Lead Lorraine and Brian Conference Action ? Inform at next scheduled call/meeting No Already contacted NO Already contacted Timing 4Q04 --- Status Pending Completed Completed Outcome/Comments Page 3 of 3 SHELL-MCCLURG-067721