Document bBVZ29pYd9kajJoKk4Yave7ak

W;. 35. No. S '1 ( iJv.-t 1 ` dC <f *-<..-** OCCUPATIONAL DISEASES 765 ,?1o. /.tr.;.*. H. Accidental Poisoning by Vinyl Chip- clinical signs, with eyar.O'is espcca.lly of the tin- a pro1 ric e: Report c; Two Cases. Canaster. A/cd. A is." ir.cn; symptom and almost all h..d lv. potef.- on s. I960, Apr. 15, v. $2, No. 16, 323-30. [12 rets.] examined a: the end of the d:;:':: in y p..t.-..la examined after 1 day\ holidav. ..bout ;-,o.. 2 :I.\r rapidly fata! cases. the second prosed by eir ."W.ar.ecs to base been closed by vinyl chloride, I'.!'., f.de dangers when safety roles are disregarded and :o\c,'logical difficulties of proof of poisoning front volr.;:N e'.ies. Also called chloroethylene or ehloro-ether.e, Crl - Cii.CI ii an explosive, heavy and volatile gas; is!' - !1C. In enclosed production of polyvinyl resin, ending shit: there was no from the original findings. The patient, nv-tli com plained of asthenia often accompanied by l,.c..d..chc both groups) and 2 showed grave ...nd 4 marked cy.ui.m., Methaemoglobin levels did no: diiter much in the 2 kind, of risk and 1 day's holiday was sudicien: to reduce Me MetHo level to nearly normal but m 3 patients even though this vvas within normal limits, cyanosis was un pol merization is not completed and, before a tank is opened, residual vinyl chloride is pumped into another rec. sery tank. The residua! gas contains 90 N vinyl chlo- changed even after 1 week's absence. The authors discuss carefully this persistence of cyano sis with normal MetHb levels and suggest that it is due ridi t>-5",, CO., vinyl acetate, trichloroethylene. N and to slowing down of th^ peripheral circulation due to the diminished oxygenation of the blood. The tree erythro 1 te first patient entered a tank to clean it. after the cytic and the urinary coproporphyrin behaved in the .:st: 1 iifety tests. Air was continuously exhausted and opposite manner, i.e., they rose after absence from work. rep. ..cd. but the air hose afterwards appeared defective, It thus appears that the toxic product causing the methac- H. lid not we^r the required safety belt and line. Nor mogiobi.naemia may also atfee; the enzyme systems wa, the required rescue apparatus immediately available synthesizing porphyrin. tr. K. Diutscotr.bc wh." t, 10 minutes later, he failed to answer. The rescuer eon i not detect vinyl chloride. The second patient was feu "d beside an open valve 20 minutes after he had ee.te.e.i s pit outside the recovery tank to open this water Palladg, Suiamith. London, Micaela, RovenT.v. Ana jc out- : va!\e from this tank. One rescuer dosed the valve, Pcinovtci. Carmen. La tossieita di un cor.cimc was jiteeted by escaping gas. became giddy, saw circles, largamente usato in agricultural II superfosfato. crawled assay shouting and recovered quickly; another, wea i.ng a respirator, removed the body. Both of the men who died had often done these tasks. A autopsy, performed 3 and S hours later, no vinyl ciilo he was found. It may have been expelled bv artifi [Toxicity of a Largely Used Agricultural Ferti lizer: Superphosphate] Med. d. Ltivoro. 1960. Jan., v. 51, No. 1. 49-5S, 5 figs. [25 refs.] English summary' (3 lines). cial -aspiration. The pathological findings in both were cyh' .conjunctival burns, congestion of internal ore. ts. especially lungs and kidneys, and failure of the bloc a ro clot. Though not diagnostic, these findings were obn-vej in experiments with vinyl chloride and are beir. : published. The first patient, aged 21, also showed slice.: heart and kidney disease. He may have fainted be:.-, e being asphyxiated. Vinyl chloride rapidly induces n.arc wi; and. ir. dogs, causes cardiac abnormality. I: is coils Jered one of the leas; dangerous of chlorinated hyd icarbons; the MAC is 500 p.p.m. .V/. Patricia Fitzsimons This report comes from the section of Industrial Hygiene of the Institute of Hygiene and Public Health of Rumania. In it the authors point out that one of the very important components of superphosphate is Fluorine which sometimes during manufacture has led to severe symptoms of mottled teeth, digestive disturbances, bony changes, atrophic rhinitis, and ulceration of the nasal mucosa occasionally going on to perforation of the septum after prolonged contact. However the toxic action of the fertilizer is due not only to its F content but to the particular solubility of the F salts and to the physical state of the fertilizer. When given iiuragastrically to rabbits superphosphate is much more toxic than the Per.x,n L., Scansctt!. G., Capcllaxo. F.. G.udo, C. & Rasetti, L. l.ndagini sull'esposittione -runiea al meta-amino-fenoio e para-nitro-etii- apatite from which it is made; the urinary elimination of F gives a precise and convenient indication of the yield to F, out after administration of non-ietha! doses to rabbits there was some retention of F. In these animals 'cr.ttolo. [Investigations on Chronic Exposure there appears to be some potentiating action of P on o iMeta-Amino-Phenol and Para-Nitro-Ethyl- the F ions as regards toxicity and after 2 doses of super- Jenzc!] Rass. Med. Indust. Rome, 1959, Nov.- pnosphate (90 mgm, Fkgm.) there was a marxej reduc Gee., v. 25, No. 6, 437--16. [IS refs.] English mm ary. tion in the activity of the blood phosphatase but no: in cholinesterase though in eitro this was also reduced. The authors conclude that in contras; to what has been thought hitherto superphosphate has a definite toxic action Th authors examined IS persons, 12 of whom were and repeated exposure of workers to small Joses may- expo c.| occupationally to risk of poisoning by meta- have some et/cct. Hence the MAC should be established, amir, i-hur.ol, and 6 by paranitroethylbcnzol. whose ages bearing in mind no; only the F content but aiso the rang.J from 24 to 51. and the length of time at such complex composition of the product. work from 2 to 7 years. All the patients showed definite >'/. K. DunsCotnhe R&s 136068