Document bB7DeoZygkpkndVRbKekLnZa3

t4/U6_ 3<337 419 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revision No. 1 Volume 4 o f 5 3X37 Revised Page DuPont-5386 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100(1998) Author: Gregory S. Ladies, Ph.D., D.A.B.T. Original Completed on: December 3, 2001 Revision No. 1 Completed on: April 5, 2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 W ork Request Number: Service Code Number l Sponsor Study Number: 1 Page 970 of 1503 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643330 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB! 971 I! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643336 Unscheduled Sacrifice Duration of dosing-days: 105 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : KIDNEYS : CALCULUS\CALCULI , BILATERAL, severe. URINARY BLADDER : CALCULUS\CALCULI, severe. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : MINERALIZATION, mild. NECROSIS, TUBULAR, mild. HYPERPLASIA, TRANSITIONAL CELL, moderate. INFLAMMATION, ACUTE, mild. THYMUS : ATROPHY, mild. 643336 Continued on the next page .... Company Sanitized. Does not contain TSCA CBt 972 I H'24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643336 Continued from previous page Histopathology : URINARY BLADDER : HYPERPLASIA, SIMPLE, TRANSITIONAL CELL, moderate. INFLAMMATION, SUBACUTE/CHRONIC, mild. HEMORRHAGE, mild. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643354 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643354 Continued on the next page .... Company Sanitized. Does not contain TSCA CBf 973 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643354 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643361 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643361 Continued on the next page .... Company Sanitized. Does not contain TSCA CB! 974 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643361 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE ) DuPont-5386 Company Sanitized. Does not contain TSCA CBf 975 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643362 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : NECROSIS, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. DuPont-5386 643362 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643362 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643374 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643374 Continued on the next page .... Company S an ili,,. Does no, comain TSCA CBI 977 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643374 Continued from previous page Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643377 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. ) DuPont-5386 643377 Continued on the next page .... 978 ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643377 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643383 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI 980 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643384 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE I DuPont-5386 Company Sanitized. Does not contain TSCACBI 981 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group ;: II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643387 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643398 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. 643398 Continued on the next page .... 983 Company Sanitized. Does not contain TSCA CB1 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643398 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643402 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643402 Continued on the next page .... company Sanitized. Does not contain TSCA CBI 984 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group :; II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643402 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 643405 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. 643405 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643405 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643406 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 643406 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643406 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643415 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, 643415 Continued on the next page .... Company Sanitized. Does not contain TSCA CBl 987 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643415 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PITUITARY GLAND : HYPERPLASIA, DIFFUSE, mild. NOSE : SQUAMOUS HYPERPLASIA, NASOLACRIMAL DUCT, mild. No Microscopic Abnormality Observed : LIVER, THYROID GLAND, MANDIBLE 643425 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643425 Continued on the next page .... ~|^ninr>nvSsnWroH Unoe not "TC f'h H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643425 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : HYDRONEPHROSIS, BILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643426 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643426 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 989 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643426 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643436 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643436 continued on the next page .... Company Sanitized. Does not contain TSCA CBI 990  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643436 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S} WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CYST, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE J DuPont-5386 Company Sanitized. Does noi conialo TSCA CEI 991 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643448 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE ! DuPont-5386 Company Sanitized. Does not contain TSCA CBt 992 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643453 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CYST, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB1 993 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643463 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : THROMBUS, minimal. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 643463 Continued on the next page .... 994 Company Sanitized. Does not contain TSCA CB )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643463 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643465 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 643465 Continued on the next page .... Company Sanitized. Does not contain TSCA CBi 995 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643465 Continued from previous page Histopathology : NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. 643477 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 643477 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 996 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643477 Continued from previous page Histopathology : PARATHYROID GLANDS : NOT PRESENT. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643484 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643484 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 997 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group :; II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643484 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. 643486 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643486 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 998 i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643486 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E {S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 999 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643321 Unscheduled Sacrifice Duration of dosing-days: 29 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, BILATERAL, PELVIS, moderate. DISCOLORATION, TAN, BILATERAL, GRANULAR . URINARY BLADDER : DILATATION, severe. CALCULUS\CALCULI, 7MM DIA. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : HYDRONEPHROSIS, BILATERAL, mild. INFLAMMATION, ACUTE, moderate. HYPERPLASIA, TRANSITIONAL CELL, mild. NECROSIS, TUBULAR, moderate. HEART : CARDIOMYOPATHY, minimal. 643321 Continued on the next page .... Company Sanitized, Does not contain TSCCB1 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643321 Continued from previous page Histopathology : SPLEEN : DEPLETION, LYMPHOID, moderate. THYMUS : ATROPHY, moderate. URINARY BLADDER : HYPERPLASIA, SIMPLE, TRANSITIONAL CELL, moderate. BONE MARROW : ATROPHY, mild. MANDIBLE : NOT PRESENT. No Microscopic Abnormality Observed : LIVER, LUNGS, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, NOSE 1 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1001 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643324 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE ) DuPont-5386 i Company Sanitized. Does not contain TSCA CB1 1002 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations 1 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643364 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE I DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1003 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643379 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. 643380 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643380 Continued on the next page .... Company Sanitized. Does nof contain TSCA CBt 1004 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643380 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643389 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643389 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1005 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643389 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. FRACTURE/CALLUS, TOOTH. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643390 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643390 Continued on the next page .... Company Sanitized. Does not contain TSCA CB! 1006 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643390 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE 643391 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643391 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643391 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 643396 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643396 Continued on the next page .... Company Sanmd. Does no|,,,,tab, TSCA CB| 1008 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643396 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE 643410 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643410 Continued on the next page .... 1009 Company Sanitized. Does not contain TSCA CB! ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643410 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643433 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643433 Continued on the next page 1010 Company Sanitized. Does not contain TSCACB ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643433 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643437 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643437 Continued on the next page .... ion Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643437 Continued from previous page Histopathology THYROID GLAND : ALTERATION, COLLOID, minimal. 643458 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643458 Continued on the next page .... company Sanitized. Does not contain TSCA CBI 1012  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643458 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643483 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/'KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, moderate. 1 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1013 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643322 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LIVER, KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1014 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643323 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1015 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643360 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. DuPont-5386 Company Sanitized. Does not contain TSCA CB 1016 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ! INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643366 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE > DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1017 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643367 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE I DuPont-5386 i Company Sanitized. D es not contain TSCA CBI 1018 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643373 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE DuPont-5386 ompany Sanitized. Does not contain TSCA CBf 1019 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643381 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, minimal. I DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1020 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643382 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND, NOSE 643392 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : LUNGS : DISCOLORATION, DARK. 643392 Continued on the next page .... 1021 Company Sanitized D oesiw -u o e s not contain TSCACB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643392 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. No Microscopic Abnormality Observed : LUNGS, THYROID GLAND, NOSE, MANDIBLE I DuPont-5386 Company Sanitized. Does not contain TSCACBI 1022  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643409 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1023 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643412 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE ) DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1024 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643461 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1025 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643462 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1026 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643472 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1027 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643489 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB! 1028 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643329 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1029 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643332 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643332 Continued on the next page .... Company Sanitized. Does not contain TSCA CB1 1030 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings Animal Ref Microscopic & Macroscopic Findings 643332 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643340 Found Dead Duration of dosing-days: 69 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : ADRENAL GLANDS : LARGE, BILATERAL, moderate. WHOLE BODY : Autolysis: tissues taken, severe. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 643340 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1031 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : vili - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643340 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : SPLEEN : DEPLETION, LYMPHOID, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. THYMUS : ATROPHY, severe. PARATHYROID GLANDS : NOT PRESENT. EYE(S ) WITH OPTIC NERVE : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. I DuPont-5386 643340 Continued on the next page .... 1032 Company Sanitized. Does no! contain TSCA CBI )I H-24516: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643340 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643341 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643341 Continued on the next page .... 1033 Company Sanitized. Does not contain TSCA C IJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643341 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. SPLEEN : NOT PRESENT. THYROID GLAND : ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW ) DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1034 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643345 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBl 1035 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643347 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal, NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643351 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, KIDNEYS, NOSE, MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CB1 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643356 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION, AMELOBLASTS, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, mild. I DuPont-5386 Company San iiid. Dona not coniata T SC A CBI 1038 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643358 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 company Sanitized. Does not contain TSCA CBI 1039 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS > DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643359 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643359 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1040 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643359 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643368 Accidentally Killed Duration of dosing-days: 53 Exposure Group : REPRODUCTION Animal is signed off from necropsy Gross Pathology : ESOPHAGUS : PUNCTURE, GAVAGE ERROR. SKIN : STAIN. RED, PERINEUM. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643368 Continued on the next page .... Company Sanitized. Does not contain TSCA CB1 1041 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group ;: VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643368 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology KIDNEYS : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, mild. SPLEEN : DEPLETION, LYMPHOID, mild. JEJUNUM : AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED, moderate. THYMUS : ATROPHY, severe. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, severe. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, severe. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. ) DuPont-5386 643368 Continued on the next page .... 1042 Company Sanitized. Does not contain TSCA CBi )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643368 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM 643370 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643370 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1043 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643370 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : INFARCT, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. PARATHYROID GLANDS : NOT PRESENT. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW I DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1044 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group ; VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643388 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : HYPERPLASIA/SQUAMOUS METAPLASIA, minimal. TRANSITIONAL CELL, DuPont-5386 Comparty Sanitized. Does not contain tSC A CD! 1045 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643404 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed .LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. 643404 Continued on the next page .... 1046 Company Sanitized. Does not contain TSCA CBi )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643404 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S} WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, MANDIBLE 643408 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 643408 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1047 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643408 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW DuPont-5386 Company Sanitized. Does not contain T SC A OBI 1048 )! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643423 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 1 DuPont-5386 Company Sanitized. Does no! contain TSCA CBI >) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS I DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643435 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, minimal. UTERUS : DILATATION, LUMEN, minimal. URINARY BLADDER : NOT PRESENT. 643435 Continued on the next page .... Company Sanitized. Does not contain TSCA 81 1050 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643435 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643441 Terminal Sacrifice Killed on Day : 125 Exposure Group -. ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643441 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643441 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Vili - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643444 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE I DuPont-5386 Com pany Sanitized. Does not contain TSCA CBI 1053 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643446 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild. PARATHYROID GLANDS : NOT PRESENT. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643446 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1054 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643446 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643450 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643450 Continued on the next page .... Company Sanitized. Does not contain TSCA OBI 1) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ') DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643450 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL, minimal. 643456 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643456 Continued on the next page .... Company Sanitized. Does no! contain TSCA CBI 1056 I! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643456 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1057 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643466 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. MESENTERIC LYMPH NODE : NOT PRESENT. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild. E Y E {S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643466 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1058 II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS ) DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643466 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643474 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643474 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1059 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643474 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643481 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643481 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI 1060 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643481 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1061 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 643487 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1062 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX O REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF MALE RATS Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF MALE RATS EXPLANATORY NOTES Notes: Test Days 7 5 - 8 9 = Cohabitation period DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1064 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS : ANIMAL NUMBER 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643254 78 85 92 99 106 602.8 514.2 515.9 624.5 465.5 441.0 522.9 564.4 507.3 560.0 635.1 525.9 651.7 565.1 587.4 524.9 582.0 562.8 677.2 482.3 614.2 539.7 520.4 644.1 480.7 454.9 533.6 575.4 522.7 578.7 636.5 540.9 675.1 580.0 591.1 539.2 597.9 574.2 696.9 494.6 627.7 552.6 539.2 647.5 484.6 465.7 556.8 595.5 528.4 586.8 649.3 551.5 692.9 596.4 617.3 557.9 601.1 587.9 716.4 512.6 625.4 562.6 556.3 664.9 506.3 482.6 569.3 608.0 538.7 598.1 669.5 570.5 704.6 604.4 627.2 563.1 613.8 600.1 725.5 522.5 648.8 569.4 569.5 681.1 513.3 493.0 575.8 626.0 541.9 614.9 676.4 582.0 716.0 617.4 637.9 577.1 631.2 605.8 738.2 536.8 Company Sanitized. Does not contain TSCA CBI 1065 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY TEST DAYS : ANIMAL NUMBER 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 78 85 92 99 106 469.8 626.4 495.5 570.3 477.4 606.8 566.9 589.6 549.5 529.1 558.2 623.5 574.0 464.8 554.3 517.3 465.1 584.7 569.3 484.8 473.5 641.6 513.5 568.3 485.6 619.3 567.9 607.3 568.7 542.3 578.2 637.1 581.1 460.9 579.6 525.8 480.6 582.7 590.0 502.0 480.6 660.3 530.1 583.2 496.3 642.7 583.2 624.1 580.6 558.4 585.8 643.9 596.7 472.6 583.1 530.9 493.3 594.2 615.9 520.0 490.8 679.0 538.7 597.3 504.1 662.5 595.4 646.7 597.8 577.8 583.8 653.0 614.6 495.0 597.7 533.7 511.3 605.3 629.5 529.5 495.4 695.9 541.3 610.4 513.9 676.7 612.9 657.4 613.5 588.6 592.1 660.5 623.5 476.9 605.2 544.7 518.4 614.2 636.2 532.8 Company Sanitized. Does not contain TSCA CB1 1066 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 78 85 92 99 106 511.6 566.3 558.8 512.4 543.0 547.4 592.5 507.2 466.6 545.1 560.7 601.1 552.8 538.6 568.5 592.7 499.6 606.0 526.7 553.2 515.1 590.0 576.7 523.6 556.5 568.7 614.7 516.6 474.0 561.9 576.0 600.0 571.6 546.3 582.1 604.7 505.8 618.5 530.6 551.9 527.8 604.1 597.7 533.3 551.1 572.7 622.7 529.3 489.0 581.2 592.4 619.0 585.7 538.2 591.1 616.0 520.2 633.6 531.9 552.4 538.8 630.8 611.8 541.9 552.8 584.7 629.1 551.4 496.6 586.5 605.6 637.4 599.9 538.8 601.2 626.2 495.1 645.2 540.9 567.7 536.6 636.4 610.9 550.9 554.2 561.4 581.4 542.0 493.4 600.9 610.9 640.7 605.3 537.4 616.0 640.0 497.4 637.4 465.9 563.9 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px MALE RATS GROUP : VII-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643281 78 85 92 99 106 403.6 536.3 577.3 499.4 505.7 429.6 443.7 490.4 477.9 491.0 542.1 513.5 481.5 509.4 513.3 578.4 433.6 447.6 530.5 431.4 572.0 596.1 528.9 542.4 457.8 457.6 501.4 506.7 508.7 563.5 512.7 485.4 519.2 539.0 599.4 473.5 472.1 538.9 440.0 592.9 615.9 554.9 567.1 464.5 473.0 507.7 516.6 511.0 579.1 529.7 489.5 538.3 559.3 626.8 500.5 478.8 544.8 449.3 611.8 624.7 565.8 576.1 419.4 480.5 523.8 524.6 515.1 597.4 536.6 498.4 528.8 574.6 654.0 524.6 486.1 548.6 454.2 627.6 632.1 576.7 587.0 397.7 495.4 534.0 538.4 518.9 604.5 538.3 505.3 529.7 584.5 674.5 540.6 496.8 560.8 Company Sanitized. Does not contain TSCA CB 1068 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX P REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, MALE RATS otnpany Sanitized. Does not contain TSCA CB 1069 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS EXPLANATORY NOTES Notes: Test Days 7 5 - 8 9 = Cohabitation period DuPont-5386 Jompany Sanitized. Does not contain TSCACB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643254 78--85 85--92 92--99 99--106 78--106 11,.4 25 .5 4 .5 19..6 15 .2 13 ,.9 10 .7 11..0 15 .4 18 .7 1,.4 15 .0 23 .4 14 ,.9 3 ,.7 14 .3 15 ,.9 11,.4 19 ,.7 12 .3 13 .5 12 .9 18 .8 3 .4 3 .9 10 .8 23 .2 20 .1 5 .7 8 .1 12 .8 10 .6 17 .8 16 .4 26 .2 18 .7 3 .2 13 .7 19 .5 18 .0 -2 .3 10 .0 17 .1 17 ,.4 21,.7 16 .9 12 .5 12 ,.5 10 ,.3 11,.3 20 ,.2 19 ,.0 11..7 8 .0 9 ,.9 5 .2 12 .7 12 .2 9 ,.1 9 .9 23 .4 6 .8 13 .2 16 .2 7 ,.0 10 .4 6 ,.5 18 .0 3 ,.2 16 ,.8 6 .9 11 .5 11 .4 13 .0 10 .7 14 .0 17 .4 5 .7 12 .7 14 .3 46 .0 55 .2 53 .6 56 .6 47 .8 52 .0 52 .9 61 .6 34 .6 54 .9 41 .3 56 .1 64 .3 52 .3 50 .5 52 ,.2 49 .2 43 .0 61 ,.0 54 .5 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF MALE RATS GROUP: I I I -0 DOSE: 25 MG/KG/DAY TEST DAYS : ANIMAL NUMBER 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 78-85 85-92 92-99 99-106 78-106 3.7 15.2 18.0 -2.0 8.2 12.5 1.0 17.7 19.2 13.2 20.0 13.6 7.1 -3.9 25.3 8.5 15.5 -2.0 20.7 17.2 7.1 18.7 16.6 14.9 10.7 23.4 15.3 16.8 11.9 16.1 7.6 6.8 15.6 11.7 3.5 5.1 12.7 11.5 25.9 18.0 10.2 18.7 8.6 14.1 7.8 19.8 12.2 22.6 17.2 19,4 -2.0 9.1 17.9 22.4 14.6 2.8 18.0 11.1 13.6 9.5 4.6 16.9 2.6 13.1 9.8 14.2 17.5 10.7 15.7 10.8 8.3 7.5 8.9 -18.1 7.5 11.0 7.1 8.9 6.7 3.3 25.6 69.5 45.8 40.1 36.5 69.9 46.0 67.8 64.0 59.5 33.9 37.0 49.5 12.1 50.9 27.4 53.3 29.5 66.9 48 .C Company Sanitized. Does not contain T S C A C B 1072 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 78-85 85-92 92-99 99-105 78-106 3 .5 23 .7 17 .9 11 .2 13 .5 21 .3 22 .2 9 ,.4 7 .4 16 .8 15 .3 -1,.1 18 .8 7 .7 13 .6 12 .0 6 .2 12 .5 3 .9 -1..3 12 .7 14 .1 21..0 9 .7 -5,.4 4 .0 8 .0 12 ,.7 15,.0 19..3 16 .4 19 ,.0 14 .1 -8 ,.1 9 ,.0 11..3 14 .4 15 .1 1,.3 0 ,.5 11 .0 26 .7 14 .1 8 .6 1,.7 12 .0 6..4 22 .1 7 ,.6 5..3 13 ,.2 18..4 14 .2 0 .6 10 .1 10 .2 -25,.1 11..6 9 .0 15..3 -2 .2 5 .6 -0 .9 9 .0 1 .4 -23 .3 -47..7 -9 ,.4 -3 .2 14 ,.4 5 .3 3 .3 5..4 - 1 ..4 14 .8 13 .8 2 .3 -7,.8 -75 ,.0 -3 .8 25 .0 70 .1 52 .1 38 .5 11..2 14 .0 -11 .1 34 ,.8 26..8 55 .8 50 .2 39 .6 52 .5 -1..2 47 .5 47 ,.3 -2 ,.2 31,.4 -60 ,.8 10 .7 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pi MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY TEST DAYS: ANIMAL NUMBER 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643281 78-85 85-92 92-99 99-106 78-106 27 .8 35 .7 18 .8 29,.5 36 .7 28 ,.2 13 ,.9 11..0 28 ,.8 17 ,.7 21,.4 -0 ,.8 3 .9 9..8 25 .7 21..0 39 ,.9 24 ,.5 8 ,.4 8 .6 20 .9 19,.8 26 .0 24 .7 6 ,.7 15 ,.4 6 ,3 9..9 2 ,3 15 ,.6 17,.0 4 .1 19 .1 20 ,.3 27..4 27 .0 6 ,.7 5 ,.9 9 ,.3 18 ,.9 8 ,.8 10 ,.9 9 .0 -45 ,.1 7 ,5 16 .1 8 .0 4 .,1 18 .3 6 ,.9 8 ,.9 -9 ,.5 15 ,.3 27,.2 24 .1 7 .3 3 .8 4 .9 15 .8 7..4 10,.9 10 .9 -21 .7 14 .9 10 ,.2 13 .8 3 ,.8 7 .1 1,,7 6 .9 0 .9 9 .9 20 ,.5 16 ,.0 10 .7 12 ,.2 50 .6 91 .3 54 .8 77 .3 81 .3 -31...9 51 .7 43 ,.6 60 ,.5 27 ,.9 62 ,.4 24 ,.8 23 .8 20 .3 71 ,.2 96 ,.1 107 ,.0 49 ,.2 30 ,.3 Company Sanitized. Does not contain TSCA CB1 1074 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Q REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter delivered; data excluded from statistical analysis. b No gestation data since no copulation plug was observed; no litter was delivered, c Data not collected due to error. d No litter delivered, however, implants were observed at necropsy. Data was excluded from statistical analysis. e No gestation data since no plug was observed, however a litter was delivered. / Dam delivered prior to collection o f Day 21G body weight. g Accidentally killed Test Day 91 (Day 14G). Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: II-O DOSE : 0 :MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319^ 643350a 643363 643397 643421 643420a 643419 643414^ 643401 643455 643378 643393-b 643447 643478 643386 0 7 14 21 306.1 274.2 318.3 302.2 304.6 - 306.1 336.7 311.1 269.9 365.6 357.8 343.8 269.6 281.1 359.5 - 322.0 281.7 287.7 328.9 294.4 355.7 333.8 334.7 - 311.0 361.8 332.2 301.7 403.0 396.0 381.6 299.9 313.9 383.3 - 350.3 308.9 308.0 339.3 322.4 382.0 344.3 363.5 - 327.3 400.1 369.3 339.6 426.8 428.2 416.5 332.9 340.2 419.9 - 394.3 340.8 337.5 322.7 394.4 478.0 349.9 451.6 318.2 476.5 -c _c 397.9 533.9 370.9 421.3 444.7 471.9 - _c 433.1 426.7 Company Sanitized. Does not contain TSCACBl 1077 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. FEMALE RATS DURING GESTATION GROUP : IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 6434453 643418 643325 643479S 643403a 643376 643422^ 643452 643475 643372 643400 643395 643457 0 7 14 21 307.2 292.4 327.7 309.8 301.0 345.8 306.5 391.8 303.8 363.9 297.8 315.9 349.0 336.1 345.7 315.4 275.4 289.7 307.2 341.6 317.4 348.1 352.4 340.4 375.2 325.8 415.8 335.6 404.7 - 323.0 336.2 374.6 375.7 374.3 339.9 287.3 316.7 339.9 366.8 358.6 386.5 386.7 375.9 412.3 345.9 434.8 364.5 388.7 333.3 368.6 401.0 392.3 383.9 358.4 322.4 339.3 368.8 447.7 -c _c 499.2 437.9 511.0 408.7 422.7 451.1 555.5 313.9 _f 400.1 445.3 386.7 489.6 371.4 _c _c Company Sanitized. Does not contain TSCA CB1 1078 H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470^ 643434 643349 643454 643333 643460 0 7 14 21 312.5 288.9 321.4 294.8 310.0 310.4 304.7 274.2 315.0 271.5 326.2 278.6 313.6 271.9 - 297.8 304.1 312.3 266.4 309.6 338.6 311.2 348.9 327.5 346.8 312.8 333.5 288.1 341.1 301.1 358.4 283.3 336.7 299.6 - 338.9 345.1 342.2 311.5 331.7 371.2 326.3 379.2 360.1 381.7 331.6 363.9 301.6 377.7 329.5 405.3 287.5 366.4 333.8 - 362.3 376.0 373.7 345.5 363.1 433.2 308.7 455.2 463.4 452.3 301.9 _c 296.6 -C 385.2 -c 282.7 410.5 381.4 - 454.8 498.7 _c 373.0 451.8 Company Sanitized. Does not contain TSCA CBl 1079 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335e 643468 643440 643430a 643431& 643326 643365 643375 643328 643348a 643346 643449 643429 643424a 0 7 14 21 276.6 255.0 331.7 284.5 295.4 273.8 292.0 272.4 - 312.0 318.5 312.8 302.1 265.7 307.5 328.1 314.1 240.8 319.8 300.5 364.9 307.1 322.1 310.0 327.6 280.6 - 325.1 350.8 361.7 346.1 276.0 263.6 361.6 348.0 267.8 345.2 336.0 399.2 341.1 354.6 347.3 363.4 282.2 362.0 369.8 401.2 384.5 283.4 -g 386.4 382.6 281.8 436.3 415.1 495.7 433.6 447.5 440.3 476.6 267.0 443.6 435.4 -C -C 283.7 -g 493.9 371.4 283.8 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX R REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION Company Sanitized. Does not contain TSCACB1 1081 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter delivered; data excluded from statistical analysis. b No gestation data since no copulation plug was observed; no litter was delivered. c Data not collected due to error. d No litter delivered, however, implants were observed at necropsy. Data was excluded from statistical analysis. e No gestation data since no plug was observed, however a litter was delivered. / Dam delivered prior to collection of day 21G body weight, g Accidentally killed Test Day 91 (Day 14G). ompany Sanitized. Does not contain TSCA CB\ 1082 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF P 1 FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319-b 643350a 643363 643397 643421 643420a 643419 6434i4d 643401 643455 643378 643393-k 643447 643478 643386 1 o 7-14 14-21 0-21 22.8 20.2 37.4 31.6 30.1 - 4.9 25.1 21.1 31.8 37.4 38.2 37.8 30.3 32.8 23.8 - 28.3 27.2 20.3 10.4 28.0 26.3 10.5 28.8 - 16.3 38.3 37.1 37.9 23.8 32.2 34.9 33.0 26.3 36.6 - 44.0 31.9 29.5 -16.6 72.0 96.0 5.6 88.1 - -9.1 76.4 _c _c -28.9 105.7 -45.6 88.4 104.5 52.0 -C 92.3 89.2 16.6 120.2 159.7 47.7 147.0 - 12.1 139.8 _c _c 32.3 176.1 27.1 151.7 163.6 112.4 - -C 151.4 139.0 Company Sanitized. Does not contain TSCA CB1 1083 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj. FEMALE RATS DURING GESTATION GROUP : IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479e 643403a 643376 643422^ 643452 643475 643372 643400 643395 643457 0-7 7-14 14-21 0-21 34.4 25.0 20.4 42.6 39.4 29.4 19.3 24.0 31.8 40.8 25.2 20.3 25.6 39.6 28.6 24.5 11.9 27.0 32.7 25.2 41.2 38.4 34.3 35.5 37.1 20.1 19.0 28.9 -16.0 - 10.3 32.4 26.4 16.6 9.6 18.5 35.1 22.6 28.9 80.9 -C _c 112.5 62.0 98.7 62.8 -12.1 86.6 166.8 - -19.4 -f -0.9 53.0 2.8 131.2 49.0 -C _c 140.5 -C -C 189.4 136.9 165.2 102.2 30.9 147.3 191.6 - 16.1 . 51.1 109.2 41.0 174.2 96.0 _c -c Company Sanitized. Does not contain TSCACBt 1084 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470fa 643434 643349 643454 643333 643460 0-7 7-14 14-21 0-21 26.1 22.3 27.5 32.7 36.8 2.4 28.8 13.9 26.1 29.6 32.2 4.7 23.1 27.7 - 41.1 41.0 29.9 45.1 22.1 32.6 15.1 30.3 32.6 34.9 18.8 30.4 13.5 36.6 28.4 46.9 4.2 29.7 34.2 _ 23.4 30.9 31.5 34.0 31.4 62.0 -17.6 76.0 103.3 70.6 -29.7 _c -5.0 55.7 -C -4.8 44.1 47.6 - 92.5 122.7 -c 27.5 88.7 120.7 19.8 133.8 168.6 142.3 -8.5 -c 22.4 _c 113.7 -c 4.1 96.9 109.5 - 157.0 194.6 -C 106.6 142.2 Company Sanitized. Does not contain TSCA CBt 1085 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj. FEMALE RATS DURING GESTATION GROUP: V I I I -0 DOSE: 250 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335e 643468 643440 643430a 643431^ 643326 643365 643375 643328 643348a 643346 643449 643429 643424a O1 ^3 43.2 45.5 33.2 22.6 26.7 36.2 35.6 8.2 - 13.1 32.3 48.9 44.0 10.3 -43.9 33.5 33.9 27.0 7-14 14-21 0-21 25.4 35.5 34.3 34.0 32.5 37.3 35.8 1.6 36.9 19.0 39.5 38.4 7.4 -9 24.8 34.6 14.0 91.1 79.1 96.5 92.5 92.9 93.0 113.2 -15.2 81.6 65.6 _c -C 0.3 -9 107.5 -11.2 2.0 159.7 160.1 164.0 149.1 152.1 166.5 184.6 -5.4 - 131.6 116.9 _c _c 18.0 -9 165.8 57.3 43.0 Company Sanitized. Does not contain TSCA CBI 1086 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX S REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING LACTATION Company Sanitized. Does not contain TSCA CBI 1087 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL BODY WEIGHTS OF P! FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter delivered. b No litter delivered, however, implants were observed at necropsy. Data was excluded from statistical analysis. c Found Dead Test Day 99 (Day 22G). d Accidentally killed Test Day 91 (Day 14G). e Found dead Test Day 106 (Lactation Day 0). 1088 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF ?! FEMALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 0 7 14 21 643352a 643343 643459 643394a 643480 643319a 643350a 643363 643397 643421 643420a 643419 643414-i-1 643401 643455 643378 643393a 643447 643478 643386 - 297.4 360.5 - 331.7 - - 367.4 356.1 320.1 - 412.6 - 312.9 305.9 389.9 - 387.7 320.5 329.0 319.1 378.4 353.2 380.0 300.2 320.1 398.0 324.1 327.2 372.2 376.9 321.5 339.2 335.8 392.7 361.0 392.4 358.8 283.8 414.8 338.7 343.3 375.9 387.2 355.5 347.9 336.3 377.8 330.8 379.1 361.1 286.3 402.9 324.0 331.8 376.7 365.9 339.1 354.3 ompany Sanitized. Does not contain TSCA CB! 1089 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pj. FEMALE RATS DURING LACTATION GROUP : IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403a 643376 643422-k 643452 643475 643372 643400 643395 643457 0 7 14 21 340.9 328.5 369.8 360.2 325.7 381.6 336.3 - 352.7 435.4 341.2 - 343.9 - 324.7 367.9 363.1 301.4 336.2 368.5 352.7 346.8 306.1 375.6 354.9 377.3 339.9 - 353.4 434.8 301.7 - 337.0 - 334.1 372.6 347.0 322.5 345.5 370.5 387.6 370.7 385.7 398.1 388.4 397.8 368.7 - 368.1 431.8 370.2 - 371.9 - 375.4 394.0 374.3 344.7 364.6 3 83.5 342.4 355.0 391.5 377.9 353.7 381.8 352.0 - 346.4 405.7 358.6 - 366.9 - 375.0 388.9 346.7 356.0 350.5 371.1 'ompany s ,,, r ,b ,. Doos no, c0,,(an ^ ^ 1090 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Pj FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454e 643333 643460 0 7 14 21 376.8 - 354.8 353.1 379.7 338.5 - 367.8 330.7 318.1 294.7 292.9 335.9 354.1 270.6 353.6 371.7 - 374.9 353.0 374.0 346.9 373.5 319.5 328.4 345.0 334.4 355.2 369.3 341.2 313.3 370.7 - 390.6 374.6 393.0 378.5 389.2 350.1 341.4 379.3 341.2 376.9 390.1 371.2 353.0 367.8 - 380.6 363.0 360.9 353.0 381.7 341.5 356.3 378.3 329.2 360.8 365.2 346.8 360.0 ompany Sanitized. Does not contain TSCA CB! 1091 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346^ 643449 643429 643424a 0 7 14 21 345.3 316.1 388.9 324.2 328.8 328.7 319.8 345.3 - - 336.2 353.2 365.3 327.5 - - 363.0 - - 350.1 331.3 408.9 343.5 341.2 359.9 322.9 304.2 - - 348.6 353.4 366.3 340.3 - 370.6 - - 362.8 352.8 415.0 348.9 371.8 319.0 348.4 384.3 - - 375.2 371.2 368.3 305.6 - 391.2 - - 345.4 259.3 306.4 283.6 357.6 362.4 319.3 390.6 - - 361.5 380.5 378.7 312.4 - 377.1 - company Sanitized. Does not contain TSCA CBf 1092 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX T REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION Company Sanitized. Does not contain T S C A C B I 1093 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS OF Pj FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No litter delivered. b No litter delivered, however, implants were observed at necropsy. Data were excluded from statistical analysis. c Found Dead Test Day 99 (Day 22G). d Accidentally killed Test Day 91 (Day 14G). e Found Dead Test Day 106 (Lactation Day 0). Company Sanitized. Does not contain TSCA CBI 1094 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj FEMALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643319a 643350a 643363 643397 643421 643420a 643419 643414-b 643401 643455 643378 643393a 643447 643478 643386 0-7 7-14 14-21 0-21 21.7 17.9 - 21.5 - - 12.6 -55.9 0.0 - -14.6 - 11.2 21.3 -17.7 - -10.8 1.0 10.2 _ 16.7 14.3 - 7.8 - - 12.4 58.6 -36.3 16.8 14.6 16.1 3.7 - 10.3 34.0 8.7 _ 0.5 -14.9 - -30.2 - - -13.3 2.3 2.5 - -11.9 - -14.7 -11.5 0.8 - -21.3 -16.4 6.4 _ 38.9 17.3 - -0.9 - - 11.7 5.0 -33.8 - -9.7 - 11.1 25.9 -13.2 -21.8 18.6 25.3 Company Sanitized. Does not contain TSCA CBt 1095 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Pj_ FEMALE RATS DURING LACTATION GROUP : IV-0 DOSE: 25 MG/KG/DAY LACTATION DAYS : ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445^ 643418 643325 643479 643403a 643376 643422* 643452 643475 643372 643400 643395 643457 0-7 11.8 18.3 -63.7 15.4 29.2 -4.3 3.6 0.7 -0.6 -39.5 -6.9 - 9.4 4.7 -16.1 21.1 9.3 2.0 7-14 14-21 0-21 34.9 23.9 79.6 22.5 33.5 20.5 28.8 - 14.7 -3.0 68.5 - 34.9 - 41.3 21.4 27.3 22.2 19.1 13.0 -45.2 -15.7 5.8 -20.2 -34.7 -16.0 -16.7 - -21.7 -26.1 -11.6 - -5.0 - -0.4 -5.1 -27.6 11.3 -14.1 -12.4 1.5 26.5 21.7 17.7 28.0 0.2 15.7 _ -6.3 -29.7 17.4 - 23.0 - 50.3 21.0 -16.4 54.6 14.3 2.6 Company Sanilizetj. Doss noi contain TSCA CBI 1096 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Px FEMALE RATS DURING LACTATION GROUP: V I -0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454e 643333 643460 0-7 -5.1 - 20.1 -0.1 -5.7 - 8.4 - 5.7 -11.2 10.3 - 50.3 41.5 19.3 15.2 - 70.6 -40.3 7-14 14-21 0-21 - 1.0 - 15.7 21.6 19.0 - 31.6 - 15.7 30.6 13.0 34.3 6.8 - 21.7 20.8 30.0 39.7 -2.9 - -10.0 -11.6 -32.1 - -25.5 - -7.5 -8.6 14.9 -1.0 -12.0 - -16.1 -24.9 - -24.4 7. 0 -9.0 - 25.8 9.9 -18.8 - 14.5 - 13.9 10.8 38.2 83.6 36.3 - 24.9 11.1 76.2 6. 4 Company Sanitized. Does not contain TSCA CBI 1097 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OP Pj. FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346<3 643449 643429e 643424a 0-7 7-14 14-21 0-21 4.8 15.2 20.0 19.3 12.4 31.2 3.1 - 41.1 - - 12.4 0.2 1.0 12.8 - - 7.6 - - 12.7 21.5 6.1 5.4 30.6 - 40.9 25.5 80.1 - - 26.6 17.8 2.0 - 34.7 - - 20.6 - - - 17.4 - 93.5 - 108.6 - 65.3 - 14.2 43.4 - 29.1 6.3 - - - 13.7 9.3 10.4 6.8 - - - 14.1 - - 0.1 - 56.8 - 82.5 - 40.6 28.8 33.7 - 0.5 45.3 - - 25.3 27.3 13.4 - 15.1 - - 14.1 - - Company Sanitized. Dona not contain TSCA C B I 1098 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX U REPRODUCTIVE TOXICOLOGY INDIVIDUAL DAILY FOOD CONSUMPTION BY P, FEMALE RATS DURING GESTATION Company Sanitized. Does not contain TSCA CBI 1099 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION BY P, FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a No litter delivered; data excluded from statistical analysis. b No gestation data since no plug was observed; no litter was delivered. c No litter delivered, however, implants were observed at necropsy. Data were excluded from statistical analysis. d No gestation data since no plug was observed, however a litter was delivered. e Accidentally killed Test Day 91 (Day 14G). Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxi city 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pj FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643352a 643343 643459 643394a 643480 643 319-k 643350a 643363 643397 643421 643420a 643419 643414e 643401 643455 643378 643393-k 643447 643478 643386 0-7 7-14 14-21 0-21 24 .5 20 .9 26 .3 27 .7 15 .4 21. 6 29. 6 25 .9 23 .3 34. 6 30 .0 30 .8 25 .5 23 .2 27 .5 27 .2 25. 3 21 .8 25 .8 25 .1 27 .7 25 .9 30 .3 26 .3 32 .5 28 .1 27 .9 35 .1 32 .3 29 .4 29 .0 37 .1 32 .6 31 .4 27 .2 22 .7 19. 8 25. 0 25. 2 25. 4 9 .0 21. 8 30. 1 28. 4 26 .2 22 .1 31 .2 23 .6 29 .4 24 .6 28 .8 30 .9 26 .3 23 .8 23 .4 23 ,.7 26 ,.4 26 -.4 18 ,.2 23 .2 30 .7 27 .5 25 .8 30 .,6 31..2 27 .,9 28..0 28 .3 29..6 29 ,.8 26 .3 22 .8 1101 Company Sanitized. Does not contain TSCA C B W H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Pj FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479*3 643403a 643376 643422e 643452 643475 643372 643400 643395 643457 0-7 7-14 14-21 0-21 23 .8 24 .1 23 .4 27 .6 27 .8 28 .5 20 .4 26 .1 25. 2 32 .1 22 .9 22 .6 24 .1 27 .1 26 .7 21. 5 23 .7 24 .0 25 .5 28..3 26 .0 26 .1 27 .4 28 .8 28 .9 22 .4 28 .4 26 .5 35 .4 22 .9 24 .6 31,.2 27 .4 26 .2 22 .3 24 .1 23 .5 28 .5 27..8 27 ,.3 27 .1 24 .6 27 ,.0 29 ,.1 26..4 6 .5 24 .8 37..1 19 ,.5 26 .4 29 .3 26 .6 24 .4 32 .5 25 .0 22 .9 26 .4 26..6 25..8 25 .5 26 ,.5 27 ,.9 28 .8 23 .1 20 ,.3 25 ,.5 34 .9 21..7 24 .6 28 ,.2 27 ,.0 25 .8 25 .4 24 ,.3 23 ,.5 26 .8 1102 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470-h 643434 643349 643454 643333 643460 0-7 7-14 14-21 0-21 26.8 22.5 25.6 25.2 28.3 21.0 26.8 22.3 23.3 24.9 27.9 17.7 22.9 22.8 - 30.0 25.6 26.7 26.9 23.8 32.4 24.2 27.7 28.8 30.1 22.4 27.6 22.8 29.8 27.5 30.7 21.2 27.2 25.0 - 28.0 26.7 28.1 29.8 26.9 29.5 16.8 26.7 28.1 30.5 18.3 28.7 19.0 33.4 27.0 26.8 18.2 22.3 23.4 - 26.3 21.5 26.6 26.6 28.1 29.6 21.2 26.7 27.4 29.6 20.6 27.7 21.3 28.8 26.4 28.5 19.1 24.1 23.7 - 28.1 24.6 27.1 27.8 26.3 Company Sanitized. Does not contain TSCA CBJ 1103 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL DAILY FOOD CONSUMPTION (grams) BY Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 643467 643443 643417 643413 643338 643335*3 643468 643440 643430a 643431^1 643326 643365 643375 643328 643348a 643346 643449 643429 643424a 0-7 7-14 14-21 0-21 32.1 25.5 27.0 29.1 25.3 - 26.7 28.9 25.4 - 25.1 29.6 27.7 30.5 24.0 14.3 31.0 22.5 19.4 30.2 26.3 26.4 28.6 29.4 27.7 29.5 22.1 27.7 30.5 31.7 32.2 24.2 36.8 26.1 25.3 22.7 31.7 23.8 24.3 18.7 32.4 28.9 26.3 17.3 28.7 27.0 30.0 27.0 23.9 _e 28.8 17.3 21.0 31.3 25.2 25.9 25.5 29.0 27.8 28.2 21.6 27.2 29.0 29.8 29.9 24.0 _e 28.7 21.7 21.0 Company Sanitized. Does not contain TSCA CBl 1104 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX V REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi MALE RATS Company Sanitized. Does not contain TSCA CBI 1105 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pj M A L E R A T S GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA RIGHT FRONT PAW(S) ALOPE C I A BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 85 92 108 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN V1 MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643242 643251 643155 643147 643276 643254 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 Company Sanitized. Does not contain TSCA CBI 1107 H-245 I6: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN V1 MALE RATS GROUP: III-O DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 Company Sanitized. Does not contain TSCA CBI 1108 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Pj. M A L E R A T S GROUP: III-O DOSE: 25 M G / K G / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643167 643223 643233 643183 643219 643263 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DES I G N TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DES I G N TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 Company Sanitized. Does not contain TSCA CBI 1109 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 ALOPECIA LEFT FRONT PAW(S) ALOPECIA LEFT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 107 85 108 85 108 , ompany Sanitized. Does not contain TSCA CBI 1110 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643227 643164 643154 643156 643208 643190 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED B Y DESIGN TEST DAY 109 Company Sanitized. Does not contain TSCA CBI mi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px MALE RATS GROUP: VII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 643192 643222 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 C O L O R E D D I S C H A R G E R I G H T E Y E (S ) R E D TEETH CLIPPED ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 107 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 107 TEETH CLIPPED COLORED DISCHARGE NOSE BLACK C O L O R E D D I S C H A R G E B O T H E Y E (S ) R E D TEETH CROOKED COLORED DISCHARGE RIGHT EYE(S) RED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 108 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 108 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 92 85 85 99 107 99 107 85 85 99 99 99 108 85 92 106 106 108 108 85 85 1112 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Pj. M A L E R A T S GROUP: V I I -0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643160 643191 643203 643282 643302 643317 643281 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 TEETH CLIPPED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 109 85 92 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX W REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION Company Sanitized. Does not contain TSCA CBI 1114 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj FEMALE RATS DURING GESTATION Footnotes EXPLANATORY NOTES a Copulation plug observed but no litter delivered. b Data not collected on day 21 due to error. c No litter delivered, however, implantation sites observed at necropsy. Notes This appendix includes only signs from rats with copulation plug observed. Company Sanitized. Does not contain TSCA CBI 1115 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643352s 643343 643459 643394s 643480 643350s 643363 6433 97-fr 643421-k 643420s 643419 643414e 643401 643455 643378 643447-b 643478 643386 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA RIGHT FRONT LEG ALOPECIA RIGHT FRONT PAW ALOPECIA RIGHT SHOULDER SORE RIGHT SHOULDER NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 21 21 21 21 21 21 21 21 Company Sanitized. Does not contain TSCA CBI 1116 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN P1 FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643399 643334^ 643464-b 643369 643490 643342 643438 6434453 643418 643325 6434033 643376 643422e 643452 643475 643372 643400 643395b 643457*> NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ALOPECIA RIGHT FRONT LEG(S ALOPECIA BOTH FRONT LEG(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI 1117 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643320 643488a 643428 643439 643353 643385a 643339* 643473a 643337* 643416 643407* 643357a 643331 643427 643434 643349 643454* 643333 643460 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STAINED ABDOMEN YELLOW NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT LEG(S) STAINED PERINEUM YELLOW NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED FOUND DEAD 03/20/01 (Test Day 99) NO ABNORMALITIES DETECTED ALOPECIA LEFT FRONT LEG(S) ALOPECIA BOTH FRONT L E G (S ) 00 7 14 00 22 22 07 14 21 Company Sanitized. Does not contain TSCA CBI 1118 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643467 643443 643417 643413 643338 643468 643440 643430a 643326 643365 643375 643328 643348a 643346 643449 643429 643424a ALOPECIA LEFT HIND QUARTERS ALOPECIA RIGHT SIDE(S) NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STAINED PERINEUM YELLOW WET PERINEUM NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ACCIDENTALLY KILLED 03/12/01 (Test Day 91) NO ABNORMALITIES DETECTED ALOPECIA BOTH REAR LEG(S) ALOPECIA RIGHT FRONT LEG(S) TEETH CLIPPED ALOPECIA RIGHT FRONT PAW(S) DIARRHEA WET UNDERBODY STAINED FACE BROWN WEAK NO ABNORMALITIES DETECTED 0 0 0 0 14 0 0 0 21 21 21 21 21 21 21 0 0 14 21 14 0 21 21 21 21 21 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX X REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING LACTATION 1120 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Pj FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a No copulation plug was observed, however, a litter was delivered. b Found dead prior to collection of Day 0 lactation clinical signs. Note This appendix includes clinical observations from lactating rats only. Company Sanitized. Does not contain TSCA CBI 1121 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Pj. F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: I I -0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643343 643459 643480 643363 643397 643421 643419 643401 643455 643378 643447 643478 643386 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 ALOPECIA LEFT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 126 1122 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Pj. F E M A L E R A T S D U R I N G L A C T A T I O N GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479a 643376 643452 643475 643372 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 132 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 DISCHARGE VAGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 122 00 7 21 0 21 7 21 Company Sanitized. Does not contain TSCA CBF 1123 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643400 643395 643457 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 643320 643428 643439 643353 643339 643337 643416 643407 643331 643427 643434 643349 643333 643460 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DES I G N TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED B Y DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DES I G N TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 120 COLORED DISCHARGE NOSE BROWN ABNORMAL GAIT OR MOBILITY HUNCHED OVER DISCHARGE VAGINAL OPENING RED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED B Y DESIGN TEST DAY 122 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA RIGHT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 120 0 21 00 07 00 00 14 21 21 21 0 21 Company Sanitized. Does not contain TSCA CB1 1125 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL CLINICAL OBSERVATIONS IN Px FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 643467 643443 643417 643413 643338 643335a 643468 643440 643326 643365 643375 643328 643449 643429-k NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 TEETH CLIPPED ALOPECIA RIGHT FRONT LEG(S) ALOPECIA LEFT FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 125 FOUND DEAD TEST DAY 106 77 14 21 21 21 00 Company Sanitized. Does not contain TSCA CBI 1126 H-24516: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Y INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION IN Pi FEMALE RATS DuPont-5386 EXPLANATORY NOTES Footnotes: a Mean cycle length was not calculable due to insufficient data. b No evidence o f copulation was found; animal was not pregnant. c No precoital interval could be calculated since no evidence o f copulation was found. d No evidence of copulation was found, but animal was pregnant. Data were excluded from statistical analysis since the animal was pregnant during part o f the estrous cycle evaluation. Abbreviations: = No Data Company Sanitized. Does not contain TSCA CBI 1128 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP II-0: 0 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 643421 643397 643363 643350 643319-b 643480 643394 643459 643343 643352 643386 643478 643477 643393L 643378 643455 643401 643414 643419 643420 23 22 25 27 35 24 25 21 24 22 29 25 23 35 27 24 23 22 25 30 22 65 23 50 24 64 89 7 71 23 2 1 75 20 68 19 71 2 1 75 27 73 24 59 24 68 17 78 26 54 22 67 25 58 26 65 32 50 24 56 23 63 13 3.80 2 27 4.00 2 12 4 .00 4 ___ a 4 6 6 10.50 ___ c 4 4 .00 3 12 4.50 5 10 5.33 1 4 4.50 3 0 4.00 1 17 4.60 8 8 4 .00 4 4 4 .00 2 20 4 .00 ___ c 1 1 4.25 6 17 5 .00 4 9 5 .00 3 18 4 .00 1 20 4 .00 4 13 6.50 1 0 Company Sanitized. Does not contain T SC A CB! 1129 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP IV-0 : 25 MG/KG/DAY ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 643325 643418 643445 643438 643342 643490 643369 643464 643334 643399 643457 643395 643400 643372 643475 643452 643422 643376 643403 643479d 26 27 24 24 26 22 22 23 23 34 23 23 24 25 21 22 24 23 22 35 31 58 26 70 17 71 8 79 31 54 23 73 36 59 13 78 22 70 18 68 22 74 13 70 25 67 24 48 19 67 27 55 29 54 22 57 5 73 17 74 12 5.00 5 4 4.20 7 13 4.00 3 13 7.33 3 15 4.00 5 5 4.00 1 5 5.00 1 9 4.00 2 9 4.00 2 15 4.83 13 4 4.00 2 17 5.00 2 8 4.00 3 28 4.00 4 14 4 . 6 7 1 18 4.67 1 17 3 .B0 3 22 4.00 3 23 4.50 1 9 4.75 ___ c Company Sanitized. Does not contain TSC A C B I 1130 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VI-0: 100 MG/KG/DAY ANIMAL NUMBER 643416 643337 643473 643339 643385 643353 643439 643428 643488 643320 643460 643333 643454 643349 643434 643470e 643427 643331 643357 643407 NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 25 20 76 4 5.00 4 23 22 65 13 5.0 0 2 25 24 68 8 4.75 4 23 22 70 9 4.25 2 21 24 67 10 5.00 1 22 27 55 18 4.67 1 25 20 60 20 4.00 4 25 8 80 12 6.67 4 25 28 60 12 4.50 4 25 24 64 12 4.75 4 21 10 62 29 3.75 1 22 27 55 18 4.33 1 23 26 61 13 4 . 5 0 2 24 25 63 13 4 . 0 0 3 25 20 76 35 91 9 4 4.00 4 0 ___ a ___ c 24 8 71 21 6.00 3 22 9 77 14 4.00 1 22 32 55 14 4.00 1 23 30 65 4 5.00 2 Company Sanitized. Does not contain T SC A CBi 1131 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643431* 643430 643440 643468 643335d 643338 643413 643417 643443 643467 643424 643429 643449 643346 643348 643328 643375 643365 643326 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VIII-0 : 250 MG/KG/DAY NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (days) 35 23 69 9 5.33 ___ c 22 18 68 14 4.33 1 24 13 79 8 9.50 4 27 7 78 15 6.00 6 33 12 88 0 6.00 ___ c 24 21 67 13 4 . 2 5 4 25 24 72 4 4.00 4 22 23 59 18 4.00 1 22 32 55 14 3.75 1 27 7 70 22 4.00 6 22 32 68 0 4.33 1 29 10 69 21 4.40 8 27 26 67 7 3.67 7 22 14 82 5 4.00 2 24 25 71 4 4.00 4 23 17 70 13 5.33 2 23 13 74 13 5.00 2 24 25 58 17 5.00 4 25 24 64 12 4 .00 4 Company Sanitized. Does not contain T S C A CB1 1132 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX Z INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN Pi FEMALE RATS Company Sanitized. Does not contain TSCA CB! 1133 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION IN ? x FEMALE RATS EXPLANATORY NOTES Notes: Test Days 54-75 Test Days 75-88 = = Premating Cohabitation period Abbreviations: D = Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. Footnotes: a No evidence o f copulation was found; animal was not pregnant, bNo evidence of copulation was found; animal was pregnant. ,,ompany Sanitized. Does not contain TSCA CBI 1134 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP II-0: 0 MG/KG/DAY ANIMAL TEST DAYS NUMBER 643421 54 55 md 56 [5 58 D ED 59 60 61 62 63 D iiE n ii D 64 65 66 67 D | S d_D 68 69 PE 70 D D 72 73 74 [Til 77 |D__D p 78 79 80 81 82 83 84 85 86 87 88 6 4 3 3 9 7 [d d p E D D d x 643363 D 643350 643319 643480 D PlarT D P E D D fei); p |D D D 7 De 1D Dl D E em EE E p E F; F 1 643394 D I D l D _D_JX 643459 D D 643343 D DD 643352 D 643386 643478 D: D DI DD iD D D sD D d " p _D_ n_D P 643447 643393 D Dr D D p E T d " D_ _D F 643378 643455 D. D XD P E ill8l p e D D F E D_ D E 643401 643414 643419 ;D_JD| 1\ D " d D DD X D EE DDD D D_ D ^d " D M 643420 D D D DXD D D [ 1 P E D_ D_ Company Sanitized. Does not contain TSCA CBI 1135 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP IV-0: 25 MG/KG/DAY DuPont-5386 Company San,'zed. Does not oontain T SC A CBI 1136  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VI-O: 100 MG/KG/DAY ANIMAL NUMBER 54 55 56 57 58 59 '60 61 643416 D D D D D D D 643337 D D DD D 643473 D DED 643339 D D D D D E D 643385 D D D ID - 643353 D 6 4 3 4 3 9 D| P EDD 643428 D I DD PEDD 643488 DDD 643320 643460 D ID 643333 D D DD 643454 D DD 643349 DD 643434 D D D ID 6 4 3 4 7 0 [D' 643427 D 643331 D DD 6433571 DD TEST DAYS 64 65 f iilfiT] 68 69 70 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 D D P TP X -i D D i d " TP D D D Bal D D E D D m P E D ID: P E D D D: p ED D P E ED D D E D DDE P ED D D ED D D ED D p D D P E m I D D TP E D D D p DQ P TT D D Dll i? H D D D_ - D D nrr K D D f Hi _D D 0 D D D Dm D D D p D D D P D Dm l D D D E E D D P E D D D: E D D P n KD D D |5 | E xtt D D "R D |D | D D p D o D _x_ E D p P D D Ti D D p E D m P E m Q D P T-1 Dl D Q p g D D Lj K R D D D DDE D P E DDEDD P m Dm n H p DD EDD DPE DD p E Dm m E D Dm E D D m yP E D E |9 B m KB H TUi n1 9 19 H (9 H 19 Ka R |g D JD_ D_ P mD P D D DE m.D D p E D DED E _D_ D D E E D E D BS IlBSlI Company Sanitized. Does not contain TSC A CB1 1137 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION GROUP VIII-0: 250 MG/KG/DAY TEST DAYS 71 72 74 75 76 78| 79 80 81 82 83 84 D P E D 15" D ra m F F F FF D D D D D D D p ED D D D D pD D D m D F H D D D E D D D X D_ _D_ F F F F P DDDXD D D B D D D E D D iE DDD p 7? D D D E E DDDDDD ED D D D HF D D P E D D P EF F FB D D P X D D ir` E _D_ D_ D_ DD EDD X li D D E D D_ D j E3 D E D D P pDDDD p E D D D EQ W T5 E D D D E [D D P 86 d pia1 D DF 88 F F Company Sanitized. Does not contain TSCA CBI 1138 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX AA REPRODUCTIVE TOXICOLOGY INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Pi MALE RATS Company Sanitized. Does not contain TSCA CBI 1139 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN Px MALE RATS GROUP 1-0 0 MG/KG/DAY Animal Number Percent Motile 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 93 90 95 99 96 91 86 94 95 94 GROUP V-0 100 MG/KG/DAY Animal Number Percent Motile 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 96 91 96 84 93 95 96 92 98 92 GROUP III-O 25 MG/KG/DAY Animal Number Percent Motile 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 89 92 78 98 95 92 91 93 96 98 GROUP VII-0 250 MG/KG/DAY Animal Number Percent Motile 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 80 89 97 95 95 92 81 89 97 88 Company Sanitized. Does not contain TSCA CBI 1140 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX BB INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Pi MALE RATS Company Sanitized. Does not contain TSCA CBI 1141 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS GROUP I-0 : 0 MG/KG/DAY Animal Number 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 Total Normal 199 200 195 197 199 198 197 197 196 198 Tail Abnormal 1 0 0 0 1 0 1 0 2 0 Head Abnormal 0 0 5 3 0 2 2 3 2 2 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 99.5 100.0 97.5 98.5 99.5 99.0 98.5 98.5 98.0 99.0 GROUP III-0 : 25 MG/KG/DAY Animal Number 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 Total Normal 199 199 198 198 199 199 192 200 198 197 Tail Abnormal 0 0 0 0 0 1 2 0 0 1 Head Abnormal 1 1 2 2 1 0 6 0 2 2 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 99.5 99.5 99.0 99.0 99.5 99.5 96.0 100.0 99.0 98.5 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS GROUP V-0 : 100 MG/KG/DAY Animal Number 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 Total Normal 195 198 198 200 199 199 199 198 198 199 Tail Abnormal 0 1 1 0 0 0 0 1 1 0 Head Abnormal 5 1 1 0 1 1 1 1 1 1 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 97.5 99.0 99.0 100.0 99.5 99.5 99.5 99.0 99.0 99.5 GROUP VII-0 : 250 MG/KG/DAY Animal Number 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 Total Normal 196 193 199 200 197 200 197 198 200 197 Tail Abnormal 2 6 1 0 0 0 0 0 0 0 Head Abnormal 2 1 0 0 3 0 3 2 0 3 Tail & Head Abnormal 0 0 0 0 0 0 0 0 0 0 Percent Normal 98.0 96.5 99.5 100.0 98.5 100.0 98.5 99.0 100.0 98.5 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX CC INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN Pj MALE RATS Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Px MALE RATS GROUP I-0 : 0 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 311.0 299.3 256.0 254.9 311.0 341.4 332.0 332.0 282.9 266.6 1067.8 1249.0 758.6 858.1 1002.4 1154.4 1195.5 1216.1 869.1 938.2 Testicular Spermatids Per testis Per g testis 109.9 128.0 147.9 131.0 144.4 151.4 146.7 103.5 118.7 119.3 69.0 81.3 90.0 84.2 86.4 103.0 100.5 65.4 75.1 89.8 GROUP III-O: 25 MG/KG/DAY Animal ____ Epididymal Sperm________ Testicular Spermatids Number Per cauda Per g cauda Per testis Per g testis 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 274.2 229.1 272.4 346.0 280.6 225.6 280.6 254.9 337.9 296.9 1191.1 850.8 906.7 1045.1 1131.3 836.3 934.9 899.9 1238.4 948.4 114.0 112.2 118.7 136.8 107.0 152.6 122.8 124.5 114.6 114.6 94.8 66.5 74.0 79.8 88.4 110.5 79.6 86.2 81.4 83.3 ompany Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN Pi MALE RATS GROUP V-0 : 100 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 339.0 285.3 301.6 240.8 261.9 321.5 187.1 249.0 281.7 312.1 1239.5 945.8 970.4 723.6 879.6 1054.7 690.2 884.2 910.9 1198.6 -0: 250 MG/KG/DAY Animal Number Epididymal Sperm Per cauda Per g cauda 643289 643171 643158 643249 643161 643248 643285 643278 643299 643274 368.3 282.9 327.3 328.5 426.7 244.3 231.5 318.0 245.5 218.6 1280.8 894.7 884.9 977.7 1116.7 906.9 742.6 897.5 859.3 895.6 Testicular Spermatids Per testis Per g testis 154.3 158.4 166.0 135.0 168.4 154.9 163.7 162.5 166.6 169.5 106.3 101.0 103.1 81.1 98.0 91.4 108.3 102.6 106.1 112.8 Testicular Spermatids Per testis Per g testis 144.4 119.8 133.9 122.2 161.3 154.3 166.0 169.5 151.4 142.6 96.1 94.0 79.1 81.5 101.8 99.4 110.8 87.3 91.3 90.7 Company Sanitized. Does not contain T SC A CBI 1146 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX DD REPRODUCTIVE TOXICOLOGY INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION company Sanitized. Does not contain H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION EXPLANATORY NOTES Notes: Column labeled "Plug Observed" + indicates that a copulatory plug was observed indicates that no copulatory plug was observed Column labeled "Litter Produced" + indicates that a litter was produced indicates that no litter was produced Footnotes: a No litter delivered, however, implantation sites were observed at necropsy. b No copulation plug was observed, however, a litter was delivered. Gestation length unknown. c Found dead on Day 22G (Test Day 99). d Accidentally killed on Day 14G (Test Day 91 ). e Found dead on Lactation Day 0 (Test Day 106). Company Sanitized. Does not contain T SC A C B i 1148 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414a 643401 643455 643378 643393 643447 643478 643386 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: 11-0,1-0 DOSE: 0 MG/KG/DAY MALE #1 ANIMAL# 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643254 PLUG OBSERVED + + + + + - + + + + + + + + + + - + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED _ + + - + - - + + + - + - + + + + + + GESTAT LENGTH( ____ 23 23 -- 23 -- 22 22 22 22 22 22 23 -- 22 22 22 Company Sanitized. Does not contain TSCA CBI 1149 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479* 643403 643376 643422a 643452 643475 643372 643400 643395 643457 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: IV-0,III-0 DOSE: 25 MG/KG/DAY MALE #1 ANIMAL# 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 PLUG OBSERVED + 4+ + + + + + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + + + + + + + GESTATION LENGTH(days) 23 22 23 22 22 22 22 22 22 21 "" 23 23 22 22 22 22 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454e 643333 643460 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VI-0,V-0 DOSE: 100 MG/KG/DAY MALE #1 ANIMAL# 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 PLUG OBSERVED + + + + + + + + + + + + + + _ + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + - + + + - + + + + + - + + + + GESTATION LENGTH{days) 22 -22 22 23 -22 -22 22 22 -23 23 -22 22 -23 23 Company Sanitized. Does not contain TSCA CBI 1151 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 FEMALE ANIMAL# 643467 643443 643417 643413 643338 643335* 643468 643440 643430 643431 643326 643365 643375 643328 643348 643346d 643449 643429e 643424 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pi GENERATION GROUPS: VIII-0,VII-0 DOSE: 250 MG/KG/DAY MALE #1 ANIMAL# 643289 643171 643158 643249 643161 643274 643248 643285 643278 643299 643192 643222 643160 643191 643203 643282 643302 643317 643281 PLUG OBSERVED + + + + + - + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + - - + + + + - - + + - GESTATION LENGTH(days) 23 22 22 22 22 -23 22 --22 22 23 23 --22 23 -- Company Sanitized. Does not contain TSCA CBI 1152 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX EE REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY Com p.,,y S ani,,2ed. Does Mn(a|n TSCA CB( 1153 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes: a No implantation efficiency can be calculated. b No litter produced; no implantation efficiency calculated. d dead Day 22G (Test Day 99); the uterus contained 17 fetuses. itally killed Day 14G (Test Day 91); the uterus contained 12 fetuses. e ro u n a dead Lactation Day 0 (Test Day 106). Abbreviations: = No data Company Sanitized. Does not contain TSCA CBI 1154 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: II-O DOSE: 0 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 643343 643459 643480 643363 643397 643421 643419 643414-b 643401 643455 643378 643447 643478 643386 12 15 15 17 16 12 16 0 15 16 8 19 15 15 10 16 15 18 17 13 15 2 16 16 8 19 15 16 __ a 93.8 100.0 94.4 94.1 92.3 __ a -- 93.8 100.0 100.0 100.0 100.0 93.8 Company Sanitized. Does not contain TSCACBl 1155 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: IV-0 DOSE: 25 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643422-k 643452 643475 643372 643400 643395 643457 14 15 14 18 14 16 14 15 15 7 15 0 12 2 17 15 8 16 17 16 14 14 14 16 17 15 16 9 16 2 15 4 18 15 8 16 82.4 93.8 100.0 __ a 100.0 100.0 82.4 100.0 93.8 77.8 93.8 -- 80.0 50.0 94.4 100.0 100.0 100.0 Company Sanitized. Does not contain TSCA CBI 1156 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: V I -0 DOSE: 100 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency- 643320 643428 643439 643353 643339 643337 643416 643407 643331 643427 643434 643349 643454e 643333 643460 6 14 14 9 15 15 6 16 9 14 16 18 -- 7 14 15 16 16 11 16 17 8 14 12 15 14 18 17 9 14 40.0 87.5 87.5 81.8 93.8 88.2 75.0 -- a 75.0 93.3 -- a 100.0 -- 77.8 100.0 :ompany Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VIII-0 DOSE: 250 MG/KG/DAY Animal Number Pups Born Number of Implantation Sites Implantation Efficiency 643467 643443 643417 643413 643338 643335 643468 643440 643326 643365 643375 643328 643346d 643449 643429e 13 12 10 12 14 14 14 18 14 9 5 11 -- 17 16 12 11 13 12 16 16 18 18 16 8 14 12 12 17 15 __ a -- a 76.9 100.0 87.5 87.5 77.8 100.0 87.5 -- a 35.7 91.7 -- 100.0 -- a Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX FF REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: Fi GENERATION ompany Sanitized. Does not contain TSCACBI 1159 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: F t GENERATION DuPont-5386 EXPLANATORY NOTES Footnotes: a No litter delivered. b Found dead test day 99 (Day 22G). c Accidentally killed test day 91 (Day 14G); no litter was delivered. d Found dead test day 106 (Lactation Day 0); data excluded from statistical analysis. e Number bom includes 13 unsexable fetuses. Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643352s 643343 643459 543394s 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 BORN _ 12 15 - 15 - 17 16 12 16 15 16 8 19 15 15 INDIVIDUAL PUP SURVIVAL: Fj GENERATION GROUP: I I -0 DOSE: 0 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 -- - - 12 12 8 8 15 15 8 8 ---- 15 15 8 8 ---- ---- 17 17 8 8 16 16 8 8 12 12 8 8 - -- - 16 16 8 8 ---- 15 IS 8 8 15 15 8 8 8 88 8 ---- 19 19 8 8 15 15 8 8 15 15 8 8 DAY 14 DAY 21 -- 88 88 -- 88 --- 88 88 88 -- 88 -- 88 88 88 -- 88 88 88 Company Sanitized. Does not contain TSCA CBI 1161 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643352s 643343 643459 643394s 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 BORN 6 12 6 - 7 8 6 11 12 10 5 12 8 10 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 .- - - 66 12 12 44 55 - --- 6 6 44 - -- - - --- 7 74 4 8 8 44 6 6 44 - --- 11 11 44 ---- 12 12 55 9 94 4 5 555 - --- 12 12 44 88 10 10 44 44 DAY 14 DAY 21 -44 55 -44 --44 44 44 -44 -55 44 55 -44 44 44 Company Sanitized. Does not contain TSCA CBI 1162 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643352s 643343 643459 643394s 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 BORN _ 6 3 - 9 10 8 6 - 5 - 3 6 3 - 7 7 5 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: I I -0 DOSE: 0 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 _ -- - -- 6 6 4444 333 3 33 - - - --- 9 94 4 44 - -- - - - - -- - - - 10 10 88 66 4 444 4 444 4444 - -- - - - 554 4 44 - - - - -- 3333 33 6 6 4444 3 33 3 33 -- ---- 774 4 44 774 4 44 554 4 44 Company Sanitized. Does not contain TSCA CBI 1163 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL PUP SURVIVAL: Fj GENERATION GROUP: I I -0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER 643352s 643343 643459 643394s 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY _ 0.50 0.80 - 0.40 - - 0.41 0.50 0.50 - 0.69 - 0.80 0.63 0.63 - 0.63 0.53 0.67 - 100.0 100.0 - .1 0 0 0 - - 100.0 100.0 100.0 - .1 0 0 0 - 100.0 93. 8 .1 0 0 0 - .1 0 0 0 100.0 100.0 - 100.0 100.0 - 100.0 .1 0 0 0 100.0 100.0 - 100.0 - 100.0 .1 0 0 0 .1 0 0 0 - 100.0 100.0 100.0 DuPont-5386 LACTATION INDEX .1 0 0 0 100.0 .1 0 0 0 - .1 0 0 0 .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 .1 0 0 0 100.0 - 100.0 100.0 100.0 Company Sanitized. Does not contain TSCA CB1 1164 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643352s S43343 643459 a5 4 3 3 9 4 643480 643319a 643350a 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 INDIVIDUAL PUP SURVIVAL: GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY % BORN ALIVE _ 100.0 100.0 100.0 - .1 0 0 0 100.0 100.0 100.0 100.0 90.0 100.0 - .1 0 0 0 100.0 .1 0 0 0 NUMBER OP MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX - 100.0 100.0 .1 0 0 0 - 100.0 100.0 100.0 - 100.0 .1 0 0 0 100.0 100.0 - 100.0 100.0 100.0 - .1 0 0 0 .1 0 0 0 - 100.0 .1 0 0 0 100.0 100.0 - 100.0 .1 0 0 0 .1 0 0 0 100.0 - 100.0 100.0 100.0 DuPont-5386 Company Sanitized. Does net contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643352s 643343 643459 a5 4 3 3 9 4 643480 643319s 643350s 643363 643397 643421 643420s 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY % BORN ALIVE _ 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX - .1 0 0 0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 100.0 - 100.0 - 100.0 100.0 .1 0 0 0 - 100.0 - 100.0 .1 0 0 0 100.0 - 100.0 100.0 100.0 DuPont-5386 ompany Sanitized. Does not contain T SC A CBI 1166 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 BORN 14 15 14 18 14 16 14 - 15 15 7 - 15 - 12 2 17 15 8 16 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP : IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY : 14 14 8 8 8 8 15 15 8 8 8 8 14 14 8 8 8 8 18 18 8 8 8 8 14 14 8 8 8 8 16 16 8 8 8 8 14 13 8 8 8 8 "-- -- 15 13 8 8 8 8 15 15 8 8 8 8 7 77 7 77 --- -- 14 14 8 8 8 8 --- -- 12 12 8 8 8 8 2 22222 17 17 8 8 8 8 14 1 2 8 8 8 8 8 88 888 16 15 8 8 8 8 Company Sanitized. Does not contain TSC A CBI 1167 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 a6 4 3 4 4 5 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 BORN 6 10 5 7 10 8 6 8 11 1 - 11 - 7 0 10 9 4 10 INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 6 6 4444 10 10 4444 5 54444 7 74 4 4 4 10 10 444 4 8 8 444 4 6 6 4444 - -- - - - 8 7444 4 11 11 4444 1 11 1 1 1 -10 10 --- - 4444 - --- - - 7 744 4 4 00 10 10 000 444 0 4 8 8 444 4 4 44 4 4 4 10 10 444 4 omPany Sanitized. Does not contain T SC A C B I 1168 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 6 43445a 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 BORN 8 5 9 11 4 8 8 - 7 4 6 - 4 - 5 2 7 6 4 6 INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 8 8 4444 5 54 444 9 94 44 4 11 11 4 444 444 444 8 8 4444 8 74 444 -- - - - - 76 4 444 444 444 666 666 - - - --- 4 44 4 44 -- - - - - 5 54 44 4 222222 7 74 4 44 6 4444 4 4 4444 4 6 5444 4 1169 ompany Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: Fj GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.43 0.67 0.36 0.39 0.71 0.50 0.43 - 0.53 0.73 0.14 - 0.73 - 0.58 0.00 0.59 0.60 0.50 0.63 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 93.3 - 100.0 100.0 100.0 93.3 .1 0 0 0 .1 0 0 0 100.0 100.0 .1 0 0 0 100.0 .1 0 0 0 .1 0 0 0 92.9 - 8 6 .7 .1 0 0 0 100.0 - 100.0 .1 0 0 0 .1 0 0 0 100.0 85.7 .1 0 0 0 93. 8 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 .1 0 0 0 100.0 - 100.0 - 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 ompany Sanitized. Does not contain TSCA CBt 1170 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: Fj GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 - 90.9 - 100.0 - 100.0 8 8 .9 .1 0 0 0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 87.5 100.0 100.0 - 100.0 - 100.0 - 100.0 .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 100.0 100.0 100.0 100.0 100. 0 100.0 100.0 100.0 100. 0 100.0 100.0 100.0 100. 0 100.0 100. 0 DuPont-5386 ompany Sanitized. Does not contain TSCA CBI 1171 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 643479 643403s 643376 643422s 643452 643475 643372 643400 643395 643457 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 100.0 - 100.0 100.0 100.0 - 100.0 - .1 0 0 0 100.0 100.0 100.0 .1 0 0 0 100.0 100.0 .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 .1 0 0 0 87.5 - 85.7 100.0 100.0 - 100.0 - 100.0 100.0 100.0 66.7 100.0 83.3 100.0 .1 0 0 0 100.0 .1 0 0 0 100.0 .1 0 0 0 100.0 - .1 0 0 0 100.0 .1 0 0 0 - 100.0 - .1 0 0 0 .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 100.0 DuPont-5386 Company Sanitized. Does not contain TSCA CB! 1172 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 643407 643357a 643331 643427 643470a 643434 643349 643454* 643333 643460 BORN 6 - 14 14 9 - 15 - 15 6 16 - 9 14 - 16 18 - 7 14 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP : VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY : 444444 - "- - - - 14 14 8 8 8 8 10 10 8 8 8 8 998 8 8 8 - - - ~-- 15 15 8 8 8 8 - ~- - 15 15 8 8 8 8 6 55555 16 0 0 0 0 0 - --" 00 14 14 -- 16 16 18 17 00 88 -- 88 88 0 8 8 8 0 8 8 8 ----- - 7 7 77 7 7 14 14 8 8 8 8 Compan, SanMaed. Doss ,, ,, rscA ^ 1173 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643320 643488s 643428 643439 643353 643385s 643339 643473s 643337 643416 643407 643357s 643331 643427 643470s 643434 643349 643454* 643333e 643460 BORN 3 - 7 9 5 - 6 - 8 5 7 - 4 5 - 6 7 - 3e 7 INDIVIDUAL PUP SURVIVAL: F 3. GENERATION GROUP: V I -0 DOSE: 100 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 2 22 22 2 - -- - - - 7 74 44 4 7 75555 5 544 4 4 -- - -- - 6 6 444 4 ----- - 8 8 4444 54 444 4 70 0 0 0 0 - -- - - - 000 000 5 54 44 4 -- 66 76 ---- 4 444 4444 --- -- - 3e 3 3 3 3 3 7 74 444 Company Sanitized. Does not contain TSCA CBI 1174 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER S43320 643488a 643428 643439 643353 6433 85a 643339 643473a 643337 643416 643407 643357s 643331 643427 643470s 643434 643349 643454-6 643333s 643460 BORN 3 - 7 5 4 - 9 7 1 9 - 5 9 - 10 11 - 4e 7 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: V I -0 DOSE: 100 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 222 22 2 - - - -- - 774444 333333 444444 -- - - - - 9 94 4 4 4 -- - -- - 774 44 4 111 11 1 90 0 0 0 0 ------ 0 00 00 0 994 44 4 -10 10 11 11 - -- - 4444 4444 --- --- 4s 4 4 4 4 4 7 7 4 4 4, 4 CompanySanitized. Does not contain TSCA CBI 1175 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385a 643339 643473s 643337 643416 643407 6 43357a 643331 643427 643470s 643434 643349 643454* 643333 643460 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: V I -0 DOSE: 100 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.50 - 0.50 0.64 0.56 - 0.40 - 0.53 0.83 0.44 - 0.44 0.36 - 0.38 0.39 - 0.43 0.50 6 6 .7 100.0 71.4 100.0 - .1 0 0 0 100.0 100.0 100.0 0.0 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 - 100.0 .1 0 0 0 .1 0 0 0 - .1 0 0 0 - 100.0 83.3 0 .0 - 100.0 - .1 0 0 0 94.4 - 100.0 100.0 100.0 - 100.0 100.0 100.0 - 100.0 - 100.0 100.0 .1 0 0 0 - 100.0 .1 0 0 0 - 100.0 .1 0 0 0 Company Sanitized. Does not contain T SC A C B I 1176 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643320 643488s 643428 643439 643353 643385s 643339 643473s 643337 643416 643407 643357s 643331 643427 643470s 643434 643349 b5 4 3 4 5 4 643333 643460 INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: V I -0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 66.7 - 100.0 77.8 100.0 - 100.0 - .1 0 0 0 100.0 .1 0 0 0 - 0 .0 100.0 .1 0 0 0 .1 0 0 0 - .1 0 0 0 100.0 100.0 - 100.0 100.0 100.0 - .1 0 0 0 - 100.0 80.0 0.0 - - .1 0 0 0 - 100.0 85.7 - 100.0 100.0 .1 0 0 0 100.0 100.0 100.0 - .1 0 0 0 100.0 100.0 - - - 100.0 - .1 0 0 0 100.0 - 100.0 100.0 DuPont-5386 Company Sanitized. Does not contain T SC A CB1 1177 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643320 643488a 643428 643439 643353 643385s 643339 643473s 643337 643416 643407 643357s 643331 643427 643470s 643434 643349 643454-b 643333 643460 INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY % BORN ALIVE NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 66.7 100.0 60.0 100.0 - 100.0 - 100.0 100.0 .1 0 0 0 0.0 .1 0 0 0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 - .1 0 0 0 100.0 0.0 - 100.0 - 100.0 100.0 1 0 0 .0 .1 0 0 0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 100.0 100.0 DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430s 643431s 643326 643365 643375 643328 643348s 643346e 643449 643429d'e 643424s BORN 13 12 10 12 14 14 14 18 - - 14 9 5 11 - - 17 16 - INDIVIDUAL PUP SURVIVAL: Fi GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 13 13 8 8 8 8 12 12 8 8 8 8 10 10 8 8 8 8 12 12 8 8 8 8 14 14 8 8 8 8 14 14 8 8 8 8 14 14 8 8 8 8 18 18 8 8 8 8 - --- - - ---- - - 13 1 2 8 8 8 8 8 88 8 8 8 111000 11 8 8 8 8 8 ---- -- ---- -- 17 17 8 8 8 8 0- - - - - ---- - - Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 543430a S43431a 643326 643365 643375 643328 6 43348 a 643346e 643449 643429d 6 43424a BORN 8 7 6 7 8 7 9 9 - 8 4 3 6 10 0 - INDIVIDUAL PUP SURVIVAL: Px GENERATION GROUP: V I I I -0 DOSE: 250 MG/KG/DAY NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 8 8 4444 7 74 4 4 4 6 6 4444 774 4 4 4 8 8 4444 77444 4 9 94 4 4 4 9 94 4 4 4 -- - - - - - -- - - - 76 4444 333333 00 00 0 0 6 44444 - - ---- - -- - - - 10 10 4444 -0 - - - - ---- -- Company Sanitized. Does not contain TSCA CB1 1180 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 6434303 64343la 643326 643365 643375 643328 643348a 643346e 643449 643429d 6434243 BORN 5 5 4 5 6 7 5 9 - - 6 5 2 5 - - 7 3 - INDIVIDUAL PUP SURVIVAL: Fj. GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 DAY 14 DAY 21 5 54 4 44 554 4 44 444 444 5 54 4 44 6 6 4444 7 7 4 4 4 4554 444 9 94 4 4 4 - -- - - - -- - - - - 6 6 4444 5 55 555 1 11 0 0 0 544 444 -- - --- - -- - - - 7 74 4 44 0- - - - - - -- - - - Company Sanitized. Does not contain TSCACBI 1181 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430a 643431a 643326 643365 643375 643328 643348a 643346e 643449 643429d 643424a INDIVIDUAL PUP SURVIVAL: Fx GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATION INDEX 0.62 0.58 0.60 0.58 0.57 0.50 0.64 0.50 - - 0.57 0.44 0.60 0.55 - - 0.59 0.00 - .1 0 0 0 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 100.0 - - 92.9 88.9 20.0 .1 0 0 0 - - .1 0 0 0 0.0 - .1 0 0 0 100.0 100.0 100.0 100.0 .1 0 0 0 100.0 100.0 - - 92.3 .1 0 0 0 .1 0 0 0 72.7 - - 100.0 - - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0.0 100.0 100.0 - Company Sanitized. Does not contain TSCA CBI 1182 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430s 643431s 643326 643365 643375 643328 643348s 643346e 643449 643429d 643424s INDIVIDUAL PUP SURVIVAL: F* GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY % BORN ALIVE NUMBER OF MALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - - 87.5 75.0 0 .0 100.0 100.0 - 100.0 100.0 .1 0 0 0 .1 0 0 0 100.0 .1 0 0 0 100.0 .1 0 0 0 - - 85.7 100.0 - 6 6 .7 - - .1 0 0 0 - - .1 0 0 0 100.0 .1 0 0 0 .1 0 0 0 .1 0 0 0 .1 0 0 0 .1 0 0 0 100.0 - - .1 0 0 0 100.0 - .1 0 0 0 - - .1 0 0 0 - - DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1183 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL PUP SURVIVAL: F 1 GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643430s 643431s 643326 643365 643375 643328 643348s 643346e 643449 643429d 643424s % BORN ALIVE 100.0 100.0 100.0 .1 0 0 0 .1 0 0 0 100.0 100.0 100.0 100.0 100.0 50.0 .1 0 0 0 100.0 0.0 - NUMBER OF FEMALE PUPS 0-4 DAY VIABILITY LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 100.0 100.0 100.0 80.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 .1 0 0 0 - 100.0 100.0 0.0 .1 0 0 0 - 100.0 - - DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1184 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX GG REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: Fi GENERATION Company Sanitized. Does not contain TSCA CBI 1185 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F , GENERATION DuPont-5386 EXPLANATORY NOTES Footnotes: a No litter delivered. b Two pups were missexed; data excluded from male and female mean pup weights. c One pup was missexed; data excluded from male and female mean pup weights. d No male pups bom. e No live pups at birth. / Found dead Day 22G (Test Day 99). g Recording error, data excluded. h No male pups bom alive. i Accidentally killed Day 14G (Test Day 91). j Found dead Lactation Day 0 (Test Day 106). k No live pups on Lactation Day 4. / No live pups on Lactation Day 7. Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams) : F]_ Generation Lactation Day 0 Animal Number 643352s Pup Sex 1 Group: II-0 2 34 Dose: 0 mg/kg/day Pup Number 56 78 9 10 li 12 643343 643459 643394s 7.90 7.40 .8 . 2 0 7.10 7.50 6.90 8.30 8.40 7.60 7.00 7.20 7.50 7.40 7.00 8.00 7.30 7.40 8.40 7.70 7.40 7.70 8.10 8.20 8.30 8.70 8.10 8.10 643480 643319s 6.50 8.50 8 . 0 0 7.40 8 . 0 0 7.90 7.20 8.40 7.40 8 . 1 0 7.30 7.90 7.80 7.90 7.70 643350s 643363 643397 643421 6.70 6.60 7.10 6.50 7.00 6.70 7.10 6.20 7.20 6.70 6.70 6.50 6.20 6.20 7.30 7.20 5.90 6.30 6.80 6.40 7.50 6.90 6.30 6.10 6.40 6.30 6.30 6.10 6.60 6.20 6.40 6.00 7.00 6.30 6.70 6.60 6.60 6.20 7.00 5.60 6.40 7.10 6.50 6.00 6.20 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: II-0 Dose: 0 mg/kg/day Animal Number 643420s Pup Sex 1 2 Pup Number -- ------ 345 6 78 9 10 11 12 643419 643414s 7.50 7.20 7.30 6.90 7 . 0 0 7.10 6.60 6 . 0 0 5.60 6.90 6.40 5.60 6.50 6.50 6 . 0 0 6 . 0 0 643401 643455 643378 643393s 6.10 5.30 7.00 6.40 8.70 8.10 6.20 5.80 6.50 5.90 9.20 6.60 6.20 5.60 6.60 6.30 7.90 7.90 6.30 6.90 6.50 7.90 6.10 6.60 6.70 8.40 6.90 7.10 5.90 6.00 7.00 6 . 2 0 6.40 5.40 6 . 1 0 7.20 6.90 5.90 643447 643478 643386 6.60 6.20 6.00 5.70 6.40 5.90 6.30 6.60 7.20 6.00 6.30 6.20 6.20 6.20 6.50 6.40 6.30 5.70 6.50 6.40 6.60 6.50 6.30 6.30 6.70 6.40 6.50 5.40 6.40 6.00 7.00 6.60 6.20 6.40 6.70 7.20 6.50 6.80 5.80 6.10 6.50 5.60 7.00 6.60 6.40 5.50 6.30 7.10 6.50 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Animal Number 643399* 643334 643464 643369 643490e 643342 643438 643445s 643418 643325 Group: IV-0 Dose: 25 rag/kg/day Pup Sex 1 7.30 7.50 6.30 6.30 8.10 6.90 6.50 6.00 7.00 6.60 7.60 6.20 6.20 6.00 2 8.10 7.40 7.10 6.40 7.50 7.40 6.90 5.70 6.90 6.40 7.20 6.90 6.30 6.30 3 8.00 7.50 6.20 6.20 7.40 6.90 6.80 6.00 6.60 5.70 7.40 7.30 5.80 5.90 Pup Number -- --------------456789 7.60 8.10 7.30 6.40 8.20 7.20 6.10 6.50 6.40 6.40 6.00 6.30 5.80 6.10 7.50 6.60 6.20 8.20 7.60 6.50 6.20 6.90 6.20 6.50 5.90 6.00 5.40 7.60 6.60 6.90 7.00 5.80 6.80 6.90 6.70 6.00 5.60 7.80 7.00 7.20 6.80 6.10 6.60 6.90 6.60 6.10 7.50 6.40 7.50 6.20 6.70 6.90 7.10 6.40 7.00 7.00 6 . B0 5.10 6.00 10 7.00 6.00 6.00 6.80 7.00 7.20 6.80 6.80 6.10 6.60 6.80 6.30 6.60 7.50 5.80 4.30 6.60 7.10 7.20 6.90 6.30 7.10 6.70 6.00 6.90 6.80 6.40 7.00 6.90 7.50 6.90 6.70 11 Company Sanitized. Does not contain TSCA C B I 1189 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: IV-0 Dose: 25 mg/kg/day A nim al Number 643479 643403a Pup Sex 1 2 Pup Number 34 5 6 7 8.30 7.00 7.50 7.70 7.60 7.20 7.20 8 9 10 643376 643422a 643452 643475e* 643372 643400 643395e 643457 6.90 6.70 7.40 6.50 7.40 6.60 7.40 6.80 6.90 7. 1 0 6 . 0 0 6.50 6.70 6.90 7.50 7.30 7.00 7.30 7.90 7.80 6.60 6.70 7.50 6.50 7.10 6.50 7.40 7.60 6.60 5.60 5.90 7.50 6.40 6.30 6.40 7.00 6.90 7.00 6.00 5.40 6.30 6.50 6.00 6.00 6.50 5.80 6.00 5.40 6.10 6.60 6.40 6.20 7.00 6.20 5.50 5.60 6.90 6.00 5.80 7.30 6.60 5.90 4.10 6.20 6.10 6.00 7.10 7.10 5.90 5.10 5.90 5.50 7.50 6.90 5.50 5.80 6.00 5.70 5.90 6.70 6.50 7.20 6.90 Company Sanitized. Does not contain TSCA CB1 1190 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 0 Group: VI-0 Dose: 100 mg/kg/day DuPont-5386 Animal Number 643320 643488a 643428 643439 643353 643385a 643339 643473a 643337 643416 Pup Sex 1 2 Pup Number 34 56 78 7.20 8 . 0 0 7.00 7.30 6.40 6.00 6.80 6.70 9.10 7.50 6.70 6.00 7.00 5.50 7.50 8.40 6.70 6.70 6.10 5.30 8.90 7.40 7.00 6.40 5.70 8.30 7.10 6.00 7.20 6.40 8.30 6.50 6.80 6.90 6.40 6.80 6.80 7.40 6.80 6.50 6.30 6 . 2 0 6.70 6.90 6.50 6.30 6.70 6.40 6 . 2 0 6 . 2 0 6.50 6.40 6.50 7. 0 0 6.00 6.20 5.50 6.20 6.60 6.40 7.10 6.80 6.50 7.60 6.40 6.50 7.00 7.20 6.10 6.60 5.20 7.20 10 11 impany Sanitized. Does not contain TSCA CBI 1191 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fx Gnration Lactation Day 0 Group : V I -0 Dose: 100 mg/kg/day Animal Number 643407 643357s Pup Sex 1 5.70 5.00 2 5.30 4.50 3 6.50 5.40 4 5.70 4.90 Pup Number 56 7 6.30 5.70 5.70 5.20 5.20 6.00 8 6.10 9 5.40 10 11 643331e 643427 643470s 643434 643349 643454f 7.70 7.10 7.10 6.70 7.30 6.80 6.70 6.70 7.80 7.00 7.00 7.10 7.10 7.10 6.70 5.50 6.50 6.20 5.70 6.00 5.90 6.10 6.50 5.50 6.20 6.10 6.50 6.20 6.30 6.00 5.60 5.70 6.40 5.60 6.50 6.20 6.30 6.70 6.70 6.30 6.00 6.50 5.60 5.80 6.20 5.90 6.40 6.00 643333? 643460 8.20 8.20 7.60 8.70 8 .,20 8 ,.20 7,.30 7.60 7.50 7.20 7.70 7.,30 7,.70 7,.10 ompany Sanitized. Does not contain TSCA CBI 1192 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fy Generation Lactation Day 0 Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Group: VIII-0 Pup Sex 1 7.20 6.90 7.00 6.80 6.30 7.50 6.80 5.30 6.80 6.60 6.90 6.00 7.80 7.50 6.30 6.00 2 6.60 6.90 6.20 6.60 6.10 5.40 7.00 6.40 6.30 5.50 6.80 6.10 7.50 6.80 6.60 6.10 3 7.00 6.80 7.20 6.70 8.00 5.70 6.10 6.70 6.90 6.20 6.30 6.50 7.80 7.60 6.40 6.10 4 7.30 6.30 7.20 6.00 8.10 7.40 7.20 6.80 6.90 6.80 7.30 6.40 7.80 6.50 6.30 5.80 Dose: 250 mg/kg/day Pup Number -- ------- 56 7.40 7.00 6.40 6.70 5.90 7.10 7.10 6.00 7 7.10 7.10 8 7.50 7.30 5.90 6.60 5.70 6.60 5.90 6.30 7.50 6.30 5.80 6.70 7.40 6.80 6.50 5.40 7.60 6.80 5.60 5.30 6.60 6.80 5.90 6.80 6.10 6.50 6.80 7.10 7.00 6.60 9 7.60 6.10 5.60 643431s company Sanitized. Does not contain T SC A CB1 1193 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 0 Group: VIII-0 Animal Pup Number Sex 1 643326 643365 643375-h 643328 643348a 5.70 6.30 6.90 7.00 5.30 5.80 5.30 2 6.60 6.50 7.60 6.50 5.30 5.60 3 6.20 6.10 7.90 7.00 6.00 5.50 4 6.90 5.50 7.20 4.90 5.20 Dose: 250 mg/kg/day Pup Humber 56 6.50 6.50 6.30 6.00 7 6.20 8 7.50 5.20 5.50 5.00 643346 643449 6434291 6.40 6.80 6.20 6.70 6.80 6.10 5.70 6.50 5.70 5.70 6.20 5.90 6.10 5.60 6.20 643424a DuPont-5386 9 10 5.80 6.10 $ ompany Sanitized. Does not contain T S C A CB1 1194 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling Group: II-O Dose: 0 mg/kg/day DuPont-5386 Animal Pup Number Sex 643352a 123 Pup Number 4 5 6 7 8 9 10 11 12 643343 643459 643394a 12 .10 13 .00 12 .70 12 ,.30 12 .20 12 .60 12 .10 11 .90 12 .00 12 .10 11..10 12 .10 11 .10 12 .30 10 .90 13 .80 13 .50 14 .20 12.10 13.00 12.70 13.80 13.60 13.30 12 .30 10 .10 13 .20 643480 643319a 14 .60 14 .20 13 .30 11..70 13 .90 12 ,.90 13 .40 14 .30 12 ,.70 12 .50 13 .20 12 .30 12.20 12.40 12.40 643350a 643363 643397 643421 10 .20 10 .90 10 .20 11 .10 11 .40 12..70 10 .70 10 .90 10 .40 10 ,.30 9.50 10 .40 10 .40 11 .00 9.90 10 .60 12 .00 11..60 12 .80 11 .90 11..70 10 .40 11.90 9.20 10 .90 11..50 11 .30 11 .40 10..50 9. 70 10.80 11 .20 9 .20 11..20 8.60 9. 80 11,.60 9.10 9 .90 10 .90 10 .20 10 .20 10,.10 9.20 10.90 ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: II-0 Dose: 0 mg/kg/day Animal Pup Pup Number Number Sex 1 2 3 4 5 6 7 8 9 643420s 10 11 12 643419 643414s 643401 643455 643378 643393s 643447 643478 643386 12.70 12.50 11.60 9.70 10.60 12.80 10.60 9.80 12.10 10.80 9.90 11.50 11.40 11.10 11.20 9.80 10.10 10.30 10.00 11.00 10.10 9.70 9.80 10.00 9.60 10.20 10.70 9.00 9.10 8.40 10.10 9.80 10.50 10.90 11.50 11.30 11.60 10.60 10.30 9.30 10.30 9.70 9.70 10.60 10.30 14.10 15.50 13.40 16.60 14.70 15.50 12.80 15.70 10.70 10.80 9.90 9.60 9.50 9.70 6.30 11.00 9.90 11.00 10.90 9.50 10.80 9.80 9.40 9.90 10.00 9.80 11.70 11.20 11.40 10.40 11.90 10.90 11.90 11.30 10.80 10.10 10.00 10.50 10.50 10.30 11.60 11.20 10.40 10.40 11.60 10.50 10.90 11.10 9.80 10.20 9.40 9.50 10.00 9.60 10.50 9.60 1196 iitipany Sanitized. Does not contain T S C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling GROUP: IV-0 DOSE: 25 MG/KG/DAY DuPont-5386 Animal Number 643399 643334 643464 643369 643490 643342 643438 643445a 643418 643325 Pup Pup Number Sex 1 2 3 4 5 6 7 8 9 10 11 13 .50 13 .80 12 .40 12 .40 12 .60 12 .10 11 .20 12 .40 12 .30 12 .60 11 .80 12 .90 11 .60 11 .50 10 .70 10 .00 10 .00 10 .70 10 .80 11 .30 11 .00 10 .90 10 .30 10 .80 10 .00 10 .80 10 .20 9.70 10 .00 13 .20 13 .90 12 .20 13 .20 12 .50 13 .00 11 .70 11 .80 11 .80 12 .60 11 12 .00 11 .90 11 .50 10 .20 10 .70 9 .40 9.70 9 .90 11 .50 9 .80 9. 50 8.50 9.40 9.10 6 .90 11 .20 10 .20 10 .20 9.40 10 .20 10.50 9. 90 10 .10 9.90 8. 70 10 .50 9.40 10 .10 9 .70 9. 80 10 .20 9.00 8.00 8 .30 8.30 13 .00 11 .20 10 .80 10 .20 10 .00 12 .60 12 .50 12 .10 12 .10 11 .40 12 .00 10 .40 11 .80 10 .50 11 .70 11 .20 10 .00 10 .20 11 .00 10 .90 9 .60 10 .50 9.90 10 .10 10 .80 9. 90 10 .50 9.80 10 .30 11 .70 11 .30 11 .00 10..80 11 .20 11..60 6 .10 11,.10 11 .00 10 .10 11..20 11..70 10..60 11,.40 13 ,.50 12 .30 13 ..00 12 .80 13 .60 12 .60 13.20 12.80 12.90 12.80 12 ,.90 11..40 12 .30 11..90 oCO Company Sanitized. Does not contain T S C A C B I 1197 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Preculling Group: IV-0 Dose: 25 mg/kg/day Animal Pup Pup Number -- --------- Number Sex 1 2 3 4 5 6 7 8 9 10 11 643479 643403^ 15.40 12.70 14.50 13.70 13.70 14.40 14.20 643376 643422s 10.40 11.40 11.10 10.50 10.50 10.80 11.10 9.80 9.70 Il.70 9.50 10.50 10.00 10.10 643452 643475d 643372 643400 643395 643457 12.40 12.40 11.80 11.50 12.70 12.30 11.10 11.60 12.70 11.00 11.70 11.70 15.10 13.50 10.10 10.20 11.10 11.10 10.40 10.00 12.20 11.00 11.00 9.60 10.30 10.90 10.10 10.90 9.20 9.50 8.60 7.70 8.70 7.10 9.70 9.00 9.30 8.60 7.90 8.60 8.00 8.10 7.80 12.60 13.80 13.40 13.00 13.20 13.20 14.40 12.90 11.70 12.00 11.10 12.60 11.30 11.20 11.60 10.80 10.50 11.50 11.00 10.30 10.50 11.20 11.70 ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: VI-0 Dose: 100 mg/kg/day Animal Number 643320 643488a Pup Sex 1 2 3 ________ 14.10 14.00 4 Pup Number -- --------- 567 8 9 10 11 643428 643439 643353 643385s 643339 643473s 643337 643416 11.20 11.00 10.90 9.90 10.40 10.70 10.20 9.10 10.50 10.60 11.10 9.10 11.00 10.20 10.20 13.60 12.40 13.30 10.20 13.60 12.30 12.00 14.40 10.80 13.30 10.40 16.70 14.70 16.50 15.80 13.70 15.4014.60 10.50 10.60 11.70 11.20 11.30 10.40 11.00 11.10 9.60 10.30 8.40 9.90 11.20 10.60 10.90 11.00 11.40 12.70 11.90 12.00 11.50 12.50 11.10 10.60 11.40 12.00 10.70 11.70 8.90 11.50 13.30 13.40 13.90 13.80 10.70 Company Sanitized. Does not contain TSCA CBI 1199 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number 643407* Pup Sex Individual Pup Weights (grams) : F]_ Generation Lactation Day 4 Preculling Group: VI-0 Dose: 100 mg/kg/day Pup Number -- --------- 123456789 10 11 643357s 643331e 643427 643470s 643434 643349 543454^ 643333 643460 12.50 11.70 11.00 12.10 11.50 11.90 11.30 11.60 11.90 13.10 11.70 11.70 11.40 12.00 9.90 8.50 10.90 9.00 8.90 9.50 10.10 10.60 10.00 6.90 10.20 8.30 10.30 10.80 10.40 10.00 9.40 9.10 9.80 8.40 8.80 7.10 8.60 10.50 8.80 8.90 8.70 9.00 9.80 9.80 9.00 8.90 8.10 15.60 14.60 13.80 14.80 13.40 14.00 13.50 12.90 12.40 12.20 11.80 12.90 12.80 12.60 12.10 12.20 11.30 12.40 12.00 12.20 11.90 ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 4 Preculling Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pup Number Pup Sex 1 2 3 4 15 6 7 8 l 10 .00 8. 50 11 .20 12 .30 9. 50 9. 50 10 .80 9.40 11 .40 11 .10 10 .40 10 .40 11 .80 9. 00 11 .60 9. 00 10 .70 8.30 12 .10 11 .00 13 .80 6. 80 12 .70 11 .30 12 .00 11 .60 10 .20 8 .80 12 .20 9. 60 9. 90 9. 90 9. 90 10 .30 11 .90 12 .30 9 .30 8 .30 11 .90 10 .70 11 .30 11 .20 9.20 8 .40 10 .20 11 .40 10 .30 10 .60 9. 10 8.80 11 .90 12 .00 7. 20 11 .80 12 .70 11 .40 11 .30 11 .50 11 .70 10 .50 10 .40 11 .20 11 .20 10 .50 8. 60 10 .00 12 .80 11 .60 9.40 9.20 11 .60 11 .70 9 .80 11 .40 9.60 12 .50 11 .00 10 .00 9. 70 7 .90 12 .40 10 .70 12 .30 10 .40 9 .30 11 .00 10 .50 11 .70 10 .90 9. 00 9 .70 13 .30 10 .90 11 .00 12 .10 10 .10 9 .60 10 .30 10 .30 8. 60 10 .70 8. 20 10 .80 11 .00 10..80 11..10 10 .20 S43431a Company Sanitized. Does not contain TSCA CB1 1201 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams) : F]_ Gnration Lactation Day 4 Preculling Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643326 643365 643375^ 643328 643348a Pup PUP Number Sex 1 2 3 4 5 6 11.40 11.70 10.80 9.90 11.00 10.10 11.10 9.70 10.90 11.10 11.30 11.30 11.40 11.30 10.80 9.80 10.50 10.20 10.90 10.30 4.80 10.10 11.30 11.40 7.90 9.80 11.70 9.20 11.40 7 8 9 10 643346* 643449 6434297 643424s 11.10 12.20 10.30 11.30 9.90 9.70 8.40 10.10 9.70 8.60 9.50 10.80 10.40 10.10 8.00 8.60 8.60 1202 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : II-O Animal Number 643352a Pup Sex 1 Dose: 0 mg/kg/day Pup Number 234 5 643343 643459 643394a 13.00 12.10 12.30 12.30 12.30 11.90 13.80 10.10 12.20 12.10 13.50 13.20 12.60 12.10 14.20 643480 643319a 14.60 13.30 13.90 12.90 13.40 14.30 13.20 12.20 643350a 643363 643397 643421 10.20 10.40 10.60 10.90 11.20 10.90 10.90 9.50 12.00 11.30 9.20 10.20 11.10 11.00 12.80 9.70 11.20 10.20 12.70 9.20 10.40 10.80 9.80 10.10 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : 11-0 Dose: 0 mg/kg/day Animal Number 643420s Pup Sex 1 Pup Number 234 643419 643414s 11 .60 10 .60 10 .60 12 .10 11 .40 11 .10 11 .20 9.80 643401 643455 643378 643393s 11 .00 9. 00 10 .90 10 .30 14 .10 15 .50 10 .10 9. 10 11 .50 9 .70 15 .50 12 9. 80 8. 40 11 .30 9. 70 13 .40 15 .70 10 11 .60 10 .60 16 .60 643447 643478 643386 10 .80 9. 50 11 .20 10 .10 11 .20 9. 50 6. 30 10 .80 10 .40 10 .50 10 .50 10 .00 9 .90 9. 80 10 .90 10 .30 10 .90 10 .50 10 .90 9. 90 11 .90 11 .60 11 .10 9. 60 oo O CD 5 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: IV-0 Dose: 25 mg/kg/day Animal Pup Number Sex 1 Pup Number 234 643399 643334 643464 643369 643490 643342 643438 643445s 13 .80 12 .40 12 .60 12 .10 12 .40 12 .30 12 .60 11 .80 10 .70 10 .80 11 .00 10 .30 10 .80 10 .20 9.70 10 .00 13 .90 12 .20 13 .20 12 .50 11 .80 12 .60 12 .00 11 .90 10 .20 10 .70 9.40 11 .50 8. 50 10 .20 10 .20 9.40 9. 90 8. 70 10 .50 10 .20 9. 00 8 .00 8 .30 8.30 10 .80 10 .00 12 .50 12 .10 11 .40 12 .00 10 .50 11 .70 10 .20 11 .00 9. 60 10 .50 10 .80 9. 90 10 .50 9.80 5 6 643418 643325 11,.30 10..80 11,.60 6.10 11,.00 10 .10 11 .20 11 .70 11..40 12..80 13 .60 13 .20 12 .90 11,.40 12 ,.30 11 .90 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1205 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day Postculling Group : IV- 0 Dose: 50 mg/kg/day Animal Number 643479 643403s Pup Sex 1 Pup Number 2345 6 15.40 12.70 14.50 13.70 13.70 14.40 14.20 643376 643422s 10.40 11.10 10.50 11.70 9.50 10.50 10.00 10.10 643452 643475d 643372 643400 643395 643457 12.40 12.40 11.50 12.70 11.60 12.70 11.70 11.70 15.10 13.50 11.10 10.40 12.20 11.00 10.30 10.90 10.10 9.20 8.70 7.10 9.00 7.90 8.60 8.00 8.10 7.80 12.60 13.80 13.40 13.00 13.20 13.20 14.40 12.90 11.70 12.00 11.10 11.20 11.00 10.30 10.50 11.20 DuPont-5386 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 4 Postculling Group : VI-0 Dose : 100 mg/kg/day Animal Number 643320 643488s Pup Sex 1 Pup Number 234 13.50 15.10 14.10 14.00 5 643428 643439 643353 643385s 643339 643473s 643337 643416 11.00 10.50 10.20 12.00 14.40 10.80 9.90 10.60 13.60 13.30 16.70 13.70 10.40 11.10 13.30 10.40 16.50 15.40 10.20 11.00 10.20 15.80 14.60 13.6 10.50 10.60 11.20 10.40 11.00 9.60 9.90 11.20 12.70 12.00 13.30 10.70 11.90 11.70 13.40 11.50 8.90 13.90 12.50 11.50 13.80 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1207 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group : VI-0 Dose: 100 mg/kg/day Animal Number 643407* Pup Sex 1 Pup Number -- -----234 5 643357a 643331e 643427 643470a 643434 643349 643454f 643333 643460 12.50 11.70 11.00 12.10 11.60 11.90 11.70 11.40 9.90 10.00 10.30 6.90 7.10 8.70 10.10 10.40 9.80 9.00 8.30 8.90 9.40 9.80 8.60 8.90 15.60 14.80 12.40 12.10 14.60 13.40 12.20 11.30 13.80 14.00 12.90 12.20 13.50 12.80 11.90 DuPont-5386 Company Sanitized Does no! contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VIII-0 Dose: 250 mg/kg/day Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pup Sex 1 Pup Number 234 5 10 .70 9. 90 7. 90 9.70 8 .30 10 .30 8 .80 10 .00 11 .20 12 .10 12 .80 12 .40 12 .30 11 .00 12 .30 12 .00 9.50 13 .80 9. 30 7.20 9 .50 6. 80 8.30 11 .80 11 .90 9.20 12 .30 10 .90 11 .30 10 .70 11 .40 11 .60 12 .00 11 .30 11 .30 11 .70 11 .60 11 .20 11 .50 9.30 10 .40 11 .70 11 .40 11 .00 10 .40 8.80 8.40 10 .50 12 .20 11 .70 9. 60 8 .20 9.60 11 .40 11 .20 11 .00 9.90 10 .30 10 .00 10 .80 10 .60 10 .50 9. 70 11 .00 643431a DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1209 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 4 Postculling Group: VIII-0 Dose: 1000 mg/kg/day Animal Number 643326 643365 643375^ 643328 643348s Pup Sex 1 Pup Number -- 234 11.00 11.70 10.80 9.90 10.90 11.30 11.10 9.70 11.40 10.50 11.30 11.30 10.90 10.30 10.80 4.80 10.10 11.30 11.40 7.90 9.80 11.70 9.20 11.40 6433464 643449 6434297 12.20 11.30 9.90 10.10 10.40 10.10 8.00 8.60 643424s DuPont-5386 1210 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fy Generation Lactation Day 7 Group : 11-0 Dose: 0 mg/kg/day Animal Number 643352a Pup Sex 1 Pup Number 234 643343 643459 643394a 19.40 18.40 22.70 17.10 18.70 19.00 21.50 20.70 19.60 18.70 22.70 19.00 19.70 18.80 22.40 20.30 643480 643319a 21.20 23.10 20.20 22.90 19.60 21.40 22.20 20.10 643350a 643363 643397 643421 19.40 17.10 17.60 16.90 16.00 14.50 16.90 16.30 20.00 19.40 13.70 IS .00 20.70 18.20 22.10 18.80 14.40 15.10 18.90 18.50 18.30 18.10 16.90 15.80 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1211 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : 11-0 Dose: 0 mg/kg/day Animal Number 643420s Pup Sex 1 Pup Number 234 643419 643414s 19.50 17.90 20.00 18.20 16.20 19.00 18.40 18.70 643401 643455 643378 643393s 17.00 14.80 16.90 14.70 19.40 18.40 17.50 15.50 17.40 15.70 20.50 22.00 17.00 15.90 17.20 17.30 19.60 22.00 17.40 16.50 15.10 23.00 16.60 19.70 643447 643478 643386 18.50 17.20 16.70 15.80 18.80 16.80 18.70 18.70 17.10 16.40 19.00 17.40 18.30 15.80 17.50 15.70 19.60 15.40 15.70 17.20 15.60 15.20 18.80 17.90 DuPont-5386 1212 Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : IV-0 Dose : 25 mg/kg/day Animal Number 643399 643334 643464 643369 643490 643342 643438 643445a Pup Sex 1 Pup Number 234 19.70 21.30 19.50 19.00 19.30 19.70 19.20 18.80 17.60 18.00 19.30 19.40 16.70 14.40 18.90 15.80 16.90 17.30 19.10 18.00 16.50 16.50 16.30 17.10 15.90 17.70 16.30 17.50 15.00 14.60 16.40 16.40 15.20 17.00 17.20 16.90 14.90 15.60 16.00 15.70 16.80 18.00 17.90 19.30 18.20 19.40 18.80 18.30 16.40 17.50 16.40 18.40 17.10 15.80 16.70 17.40 5 6 643418 643325 9.20 19.30 17.80 18.80 17.20 17.70 18.80 18.20 19.00 22.30 20.70 22.80 21.70 19.60 21.90 19.70 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1213 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group : IV -0 Dose : 25 mg/kg/day Animal Number 643479 643403a Pup Sex 1 Pup Number 234 5 6 22.50 21.00 21.40 19.10 18.10 19.60 20.: 643376 643422a 17.70 19.20 15.60 16.80 15.00 16.60 15.10 17.20 643452 643475^ 643372 643400 643395 643457 19.40 20.10 19.60 18.00 18.30 19.30 18.40 18.20 22.50 20.60 17.90 17.00 18.80 17.90 17.10 17.00 15.50 15.80 12.50 14.40 13.00 10.60 13.40 11.90 12.80 12.20 19.40 20.90 20.40 21.20 19.90 19.00 18.70 20.40 19.90 20.80 19.00 17.90 18.20 18.10 17.80 17.30 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1214 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Pi Generation Lactation Day 7 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643320 6434B8a Pup Sex 1 Pup Number 234 22.50 21.20 21.30 22.60 5 643428 643439 643353 6433 85a 643339 643473s 643337 643416 17.10 17.70 20.50 17.10 23.50 20.80 17..40 17..80 16,.90 18..00 23 ,.30 22 ,.40 18..10 18 .50 20 .80 20 .00 21 .30 20 .50 17..80 16 .90 16,.90 23..50 16 .20 17.70 18 ,.10 17..10 17 .00 17.50 16..00 17.,50 16,.30 20.30 18.50 17.70 15.00 19..40 19..50 18 .10 21 .70 19 .40 19 .20 20 .10 15 .70 19 .00 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1215 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): F Generation Lactation Day 7 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643407* Pup Sex 1 Pup Number 234 5 643357a 643331e 643427 643470a 643434 643349 643454^ 643333 643460 19.80 17.80 19.50 19.20 19.10 19.00 19.30 19.30 17.10 14.10 16.60 15.40 14.90 15.80 17.60 13.70 15.90 11.40 17.60 14.80 16.90 10.70 15.40 14.00 20.90 20.60 16.20 14.30 22.70 19.70 16.00 15.00 20.20 21.30 15.90 15.10 19.50 15.50 13.90 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1216 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: VIII-0 Animal Number Pup Sex 643467 643443 643417 643413 643338 643335 643468 643440 643430a 12 .40 11,.50 18 .80 18 .10 20 .00 15..00 13 .10 16 .80 16..50 16 .70 19 .50 17..20 13 .80 16..40 12 .20 12 .70 Dose: 250 mg/kg/day Pup Number 234 10,.20 13 .60 20,.10 19..00 12 .90 17 .20 18 .10 16 .50 15 .90 16 .00 19 .60 15 .40 11 .80 16 .10 11 .80 12 .30 13 .50 15 .60 19 .60 19 .50 9 .60 11 .80 16 .20 16 .90 15 .80 14 18 .30 17 .60 17 .10 12 12 .80 10 .80 oo oo 13 .80 11 .30 20 .20 19 .50 14 .90 9 .80 18 .40 15 .20 16 .30 16 .50 17 .80 15 .20 17 .90 17 .20 11 .70 11 .90 643431a Company Sanitized. Does not contain TSCA CBI 1217 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 7 Group : VI11-0 Dose: 250 mg/kg/day Animal Number 643326 643365 643375h >1 Pup Sex 1 14.80 17.70 14.90 12.60 Pup Number 234 17.10 16.70 14.10 13.90 18.40 17.80 14.80 12.90 16.90 15.80 13.60 5 14.60 643328 643348a 12.20 17.60 15.00 16.00 16.20 17.30 17.30 14.60 643346 643449 6434297 15.20 15.80 20.30 17.10 17.60 15.30 15.80 13.50 643424a DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1218 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group : II- 0 Dose: 0 mg/kg/day Animal Number 643352s Pup Sex 1 Pup Number 234 5 643343 643459 643394s 37.90 36.00 43.70 36.00 40.90 38.10 43.10 40.60 39.20 37.20 44.50 40.50 38.70 37.30 40.60 46. 643480 643319s 43.30 45.00 43.70 46.30 44.50 41.90 43.30 43.90 643350s 643363 643397 643421 38.20 39.60 41.00 34.80 30.60 31.60 42.30 38.80 33.30 35.80 33.30 30.60 43.10 36.80 34.60 33.10 30.30 32.10 41.00 40.10 37.20 35.20 34.80 32.10 DuPont-5386 Company Sanitized. Does not contain TSCA CBl 1219 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group : II-O Dose: 0 mg/kg/day Animal Number 643420a Pup Sex I Pup Number 234 5 643419 643414a 43.30 42.10 42.90 41.60 38.50 41.10 40.70 41.30 643401 643455 643378 643393a 35.70 35.00 36.20 32.30 36.70 40.10 35.70 31.30 35.30 30.60 38.90 39.60 36.30 33.80 35.30 34.50 38.10 33.60 37.40 30.50 35.20 37.30 643447 643478 643386 39.50 34.00 36.90 37.20 39.80 37.10 37.50 36.40 37.60 36.50 39.20 39.60 37.30 35.50 38.80 38.80 40.20 37.50 34.30 38.00 38.70 37.40 40.90 37.40 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1220 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Gnration Lactation Day 14 Group: IV-0 Dose: 100 mg/kg/day Animal Number 643399 643334 643464 643369 643490 643342 643438 643445a Pup Sex 1 Pup Number 2 34 39..90 39,.00 39 .10 37 .20 37 .40 37 .30 38 .70 36 .90 38..30 38 .50 37 .60 38 .20 37 .10 34 .60 38 .00 35 .30 38 .,30 40 .10 38 .20 41..10 37 .,50 38 .20 37 .90 37 .40 36.,00 37 .90 35 .70 38 .30 35.,30 37..20 34 .40 36,.20 35 .10 37..70 34 .30 36 .50 33 .80 34 .80 33 .70 36 .30 39 ,.30 41..70 38 .20 42 .70 39 .80 38 .90 40 .30 39 .10 34 .90 33 .80 37..70 36 .90 37 .10 34 .40 36 .50 32 .90 5 6 643418 643325 39..00 37..80 38,.30 25.,10 37 .60 36 .10 37 .90 38 .10 47 .10 42 ,.80 46 .90 44 ,.90 43 .20 45 ,.20 46 .40 40 .60 DuPont-5386 lompany Sanitized. Does not contain TSCA CBI 1221 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fy Gnration Lactation Day 14 Group: IV-0 Dose: 100 mg/kg/day Animal Number 643479 643403a Pup Sex 1 Pup Number 2 34 5 6 39.90 35.10 35.90 40.20 36.70 31.30 34.40 643376 643422a 34.70 34.40 33.70 39.90 31.20 31.00 35.80 32.20 643452 643475d 643372 643400 643395 643457 36.30 38.00 36.70 36.90 36.40 37.00 35.80 34.60 39.80 38.50 38.40 39.60 37.00 37.00 35.40 35.80 33.90 32.60 32.20 29.90 27.30 30.70 32.20 30.00 28.90 29.50 37.50 36.80 36.50 38.20 37.30 35.30 37.00 36.10 40.10 40.80 39.30 36.30 38.30 38.60 38.70 37.80 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1222 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams) : F]_ Generation Lactation Day 14 Group: VI-0 Dose : 100 mg/kg/day Animal Number 643320 6434 88a Pup Sex 1 Pup Number 234 44.60 43.00 43.90 41.20 5 643428 643439 643353 643385s 643339 643473s 36.10 36.20 36.40 38.80 40.20 35.40 36.40 34.40 37.80 35.00 38.40 36.20 33.60 32.70 38.70 34.80 39.60 31.40 34.50 33.60 32.50 39.80 38.30 38.8 36.10 38.00 38.90 37.10 39.50 34.20 35.50 35.80 643337 643416 38.40 38.50 36.20 32.40 41.30 37.70 36.10 38.80 39.60 35.30 40.70 33.20 38.10 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1223 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams) : F]_ Gnration Lactation Day 14 Group: VI-0 Dose: 100 mg/kg/day Animal Number 643407^ Pup Sex 1 Pup Number -- 2345 643357a 643331e 643427 643470e 643434 643349 643454f 643333 643460 35.70 39.90 36.20 36.80 36.50 37.40 38.20 36.70 31.60 34.40 37.10 34.30 23.50 27.90 30.30 32.60 28.30 34.30 34.40 32.00 30.10 32.20 31.10 29.90 36.30 38.00 40.30 38.80 35.80 35.70 35.60 33.40 34.90 33.20 34.90 32.10 32.20 32.50 33.40 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group : VIII-0 Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pup Sex 1 30 .40 25 -.50 35 ,.10 32 .,20 34 .40 31 .50 28 .90 25 .80 30 .70 31..60 29 .60 29 .60 32 .80 36 .90 28 .10 28 .50 Dose: 1000 mg/kg/day Pup Number 2 34 25 .60 34 .10 34 .00 34 ,.90 26 ,.90 19 ,.60 25 ,.90 26 .90 33 .00 29 .80 31..30 27 .10 37 .70 35..20 26 .90 25 .50 16 .70 30..50 35..30 32 .50 20..50 27 .90 28,.00 26 .60 31 .00 32 .20 31,.20 29..00 28,.10 33 .60 26 .00 29 .00 24 .30 23 .60 34 .80 33 .80 28 ,.20 24 ,.90 22,.30 26 .30 33 .10 31,.50 29,.90 26 ,.80 35 ,.70 31 .10 30 .10 29 .70 S 643431a DuPont-5386 Company Sanitized. Does not contain T SC A CBI 1225 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fy Gnration Lactation Day 14 Group: VIII-0 Animal Number 643326 643365 643375^/1 Pup Sex 1 33.40 30.70 30.00 28.00 Dose: 1000 mg/kg/day Pup Humber 234 32 50 31 70 29 30 29 00 32.50 33.10 23.30 28.20 30.20 31.80 26.90 5 26.90 643328 643348a 20.80 27 40 24 .10 25..20 21.90 23 60 26..40 25..60 6433464 643449 6434290 35.50 35.20 36 .60 31.80 33 .00 28.80 33.30 31.60 643424a DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Individual Pup Weights (grams): Fi Generation Lactation Day 21 tf****. Group : II-O Dose: 0 mg/kg/day Animal Number 643352a Pup Sex 1 Pup Number 234 5 643343 643459 643394a 66.50 58.70 72.00 67.40 64.30 61.00 67.80 65.60 65.60 64.00 69.90 59.10 62.70 59.30 71.70 643480 643319a 70.90 79.00 77.40 73.20 72.50 72.80 71.50 67.40 643350a 643363 643397 643421 67.60 65.30 62.20 55.60 45.70 45.30 68.30 61.80 60.10 57.60 47.60 47.70 66.30 65.20 58.10 57.40 44.20 44.10 73.60 62.00 64.60 55.10 49.50 45.90 Company Sanitized. Does not contain TSC A CBI 1227 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Iradividual Pup Weights (grams) : Fi Gnration Lactation Day 21 Group : II-O Dose: 0 mg/kg/day Animal Number 643420a Pup Sex 1 Pup Number 234 5 643419 643414a 62.50 62.30 66.30 63.70 66.80 58.60 63.70 60.50 643401 643455 643378 643393a 57.70 56.20 56.90 54.20 66.70 65.50 61.00 56.00 55.20 49.50 61.60 54.30 56.20 50.30 48.40 57.50 60.40 63.10 57.40 54.00 46.50 59.60 643447 643478 643386 58.80 58.60 63.80 58.60 66.90 64.40 62.60 50.70 59.00 61.30 67.90 59.70 56.20 57.50 61.30 63.50 66.30 60.60 59.50 58.40 59.70 58.50 63.00 58.30 DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 GROUP: IV-0 DOSE: 25 MG/KG/DAY Animal Number 643399 643334 643464 643369 643490 643342 643438 643445s 643418 643325 Pup Sex 1 Pup Number 2 34 59..80 65..50 65..20 67 ,.50 59..40 62 .60 64 .90 61..40 60,.30 61..90 61..30 63 ,.20 61..00 61..80 56..60 58..50 70 .50 66..90 67..80 68 .10 65 .20 61..80 63 ,.70 63 .90 63 .30 59..50 57..20 56..40 56,.80 54 .60 55 .70 56 .30 55 .20 65 .40 53 .80 58 .10 56 .40 57 .20 52 ,.70 54 .50 67 .50 61..10 67..80 64 ,.50 61 .70 61..80 61..90 65 .10 54 .30 63 .00 56..80 62 .00 62 .00 53 .90 58,.50 59..10 61..60 39,.30 59 ,.40 60 .20 57 .00 56..20 56 ,10 59..90 68 ,.70 77..90 70 ,.10 72 ,.90 66..40 66 .60 72 .30 69 .00 5 6 DuPont-5386 Tampany Sanitized. Does not contain T SC A CBi 1229 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group : IV- 0 Dose: 25 mg/kg/day Animal Number 643479 643403s Pup Sex 1 Pup Number 2345 6 70.90 60.40 69.60 60.20 66.10 61.20 60.50 643376 643422s 54.00 56.60 56.00 64.30 49.50 55.70 50.10 44.80 643452 643475d 643372 643400 643395 643457 62.50 66.60 60.90 61.70 60.40 60.30 61.00 58.40 66.50 67.00 62.00 66.20 62.80 64.80 55.60 58.00 61.10 56.50 47.00 47.30 51.90 42.10 45.60 43.90 48.20 46.70 61.00 60.60 58.30 59.50 60.50 56.80 58.80 56.00 57.00 61.40 58.40 63.50 56.90 55.60 58.80 59.00 DuPont-5386 m pany Sanitized. Does not contain T SC A CBI 1230 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams ): Fi Generation Lactation Day 21 Group : VI-0 Dose : 100 mg/kg/day Animal Number 643320 643488a Pup Sex 1 Pup Number 234 68.50 60.50 60.60 65.70 5 643428 643439 643353 643385a 58.40 54.00 59.00 60.40 65.80 64.30 57.10 56.70 61.40 56.50 60.30 50.20 58.70 54.20 55.10 53.10 66.10 59.70 52.10 52.10 60.40 66.30 59.00 643339 643473a 643337 643416 59.40 60.30 56.60 56.60 53.10 58.80 57.70 55.80 62.60 55.90 61.30 54.30 64.20 61.40 64.50 64.40 52.80 63.30 60.70 62.50 59.90 DuPont-5386 Company Sanitized. Does not contain T SC A CBl 1231 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-5386 Individual Pup Weights (grams): Fi Gnration Lactation Day 21 Group : VI-0 Dose: 100 mg/kg/day Animal Number 643407* Pup Sex 1 Pup Number 23 4 5 643357a 643331e 643427 643470a 643434 643349 643454f 643333 643460 63.10 61..70 62,.40 66 .00 60.80 57 .30 57 .80 60 .40 59.20 38.90 43.90 46.30 50..30 45 .30 56..30 48..90 56..10 48 .00 51 .60 51,.60 53 .40 51..50 55 .80 49 ,.30 58.80 66..70 63 .70 59.60 61,.60 60 .10 56 .10 63 .20 64 .90 64 .50 59 ,.60 55.70 57 .00 56..00 60 ,.10 Company Sanitized. Does not contain T SC A CBI 1232 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Pi Generation Lactation Day 21 Group: VIII-0 Animal Number 643467 643443 643417 643413 643338 643335 643468 643440 Pup Sex 1 43 ..70 45 .10 38 .,10 35..60 32..00 33 .60 31..20 36..10 49..60 50 .30 54..60 49..00 43 .40 60 .30 45..00 44 .60 Dose: 250 mg/kg/day Pup Number 234 54 .00 43 ,.00 39 .20 35 .10 23 .00 22 .10 39 .50 34 .20 50 .30 46 .10 50 .80 45 .50 59 .10 52 .80 46 .60 48 .90 29..80 54 .60 35 .70 35..70 29 ,.00 30 .30 37 .00 34 .60 52..80 51,.70 56..90 49 .00 57 .80 55 .70 53 .,60 50 .70 42 .60 58 .40 41..30 39..70 40 .00 27 .90 40 .80 35..80 50 .70 47,.60 50 .70 45 .20 52 .40 45 .60 48 .50 49..00 ! 643431a DuPont-5386 Company Sanitized. Does not contain T SC A CBl 1233 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VI1I-0 Dose: 250 mg/kg/day Animal Number 643326 643365 643375h,1 Pup Sex 1 Pup Number 2 34 5 53.70 53.50 49.40 51.20 55.40 50.60 53.50 52.20 39.90 47.10 46.50 44.70 41.80 42.90 44.00 43.60 643328 643348a 34.60 47.50 41.00 43.40 45.50 39.70 45.60 40.40 643346 643449 6434297 52.40 53.10 60.40 55.70 47.40 58.40 54.30 51.50 643424a DuPont-5386 Company Sanitized. Does not contain T SC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX HH REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION Company Sanitized. Does not contain T S C A CBI 1235 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F! GENERATION EXPLANATORY NOTES Footnotes a No live pups bom Company Sanitized. Does hot contain T SC A CBI 1236 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L L I T T E R C L I N I C A L O B S E R V A T I O N S : Fi G E N E R A T I O N GROUP: I I -0 DOSE: 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643343 643459 643480 643363 643397 643421 643419 643401 643455 643378 643447 643478 643386 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain T SC A C B 1237 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F1 GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643452 643475 643372 643400 643395 643457 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1238 company S a nitized. D o e s not contain T SC A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fx GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643320 643428 643439 643353 643339 643337 643416 643407 643331a 643427 643434 643349 643333 643460 NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ompany Sanitized. Does not contain T SC A CB1 1239 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F1 GENERATION GROUP: VIII-0 DOSE: 250 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 643467 NO ABNORMALITIES DETECTED 643443 NO ABNORMALITIES DETECTED 643417 DAY 21 3 OF 8 2 OF 8 DISCHARGE NOSE BLACK WEAK LITTER SUMMARY 3 2 DISCHARGE NOSE WEAK DAY 21 PUP DATA: PUP: a DISCHARGE NOSE BLACK WEAK b DISCHARGE NOSE BLACK WEAK c DISCHARGE NOSE BLACK 643413 NO ABNORMALITIES DETECTED 643338 NO ABNORMALITIES DETECTED 643335 NO ABNORMALITIES DETECTED 643468 NO ABNORMALITIES DETECTED 643440 NO ABNORMALITIES DETECTED 643326 NO ABNORMALITIES DETECTED 643365 NO ABNORMALITIES DETECTED 643375 NO ABNORMALITIES DETECTED 643328 NO ABNORMALITIES DETECTED 643449 NO ABNORMALITIES DETECTED 643429a Company Sanitized. Does not contain TSCA CB\ 1240 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX n REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: Fi GENERATION Company Sanitized. Does not contain T SC A CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. a No data due to weighing error. DuPont-5386 Company Sanitized. Does not contain TSCA CBl 1242 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Ft MALE RATS GROUP : 1-1 DOSE : 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1 8 15 22 29 36 62.7 74.6 73.2 73.6 64.6 49.5 63.7 58.1 54.0 67.2 59.5 59.7 63.0 103.2 132.2 118.0 130.1 115.0 94.7 107.2 98.9 93.7 114.4 101.1 95.2 109.0 156.5 207.8 182.8 201.1 181.8 156.0 176.4 154.7 153.0 179.9 167.6 158.8 162.3 204.0 279.5 248.8 264.2 243.5 213.7 250.0 215.9 218.3 250.6 227.3 228.7 227.5 251.7 352.7 310.2 336.7 307.8 265.6 325.4 257.3 279.2 282.6 273.9 302.6 285.8 303.9 411.7 326.6 333.8 367.0 325.4 314.3 323.3 284.7 366.5 349.4 325.9 302.2 Company Sanitized. Does not contain T SC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fj. MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1 8 15 22 29 36 67.5 63.2 68.1 56.4 58.1 64.5 62.0 60.2 72.9 70.9 64.3 61.7 64.8 42.1 59.5 63.5 106.2 108.5 103.3 97.6 103.5 105.7 102.2 107.1 122.8 113.1 104.3 108.7 103.4 73.3 95.2 108.2 176.4 172.2 158.8 156.8 166.5 163.7 167.0 168.5 187.5 176.0 165.5 170.8 164.4 118.6 145.1 165.0 230.8 236.4 213.2 215.0 225.8 232.3 234.8 237.5 242.4 231.0 224.4 231.7 229.1 171.6 207.3 220.4 301.6 282.6 278.2 276.4 290.2 247.0 260.1 293.3 319.2 285.7 280.5 308.6 279.2 222.2 261.9 272.8 _a 343.9 304.5 336.7 348.4 341.2 283.5 363.8 383.2 341.5 302.5 376.1 311.9 276.8 324.0 339.1 ompany Sanitized. Does not contain T SC A CBI 1244 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP : V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 1 8 15 22 29 36 60.5 52.1 48.2 66.3 56.6 60.7 59.9 66.0 53.4 55.8 63.7 59.6 99.6 92.8 81.8 114.4 98.8 106.5 98.0 109.8 96.1 94.4 104.7 108.8 151.8 150.0 135.3 181.3 167.6 168.7 158.9 175.1 157.7 150.7 165.0 173.0 217.6 212.6 203.5 244.6 221.1 231.2 223.3 237.6 225.3 210.1 223.4 225.2 264.4 279.5 232.7 315.5 302.2 267.4 280.7 275.2 286.7 274.0 288.7 283.9 276.6 298.2 259.1 382.7 375.5 299.1 300.9 305.1 300.2 300.1 313.4 314.5 Company Sanitized. Does not contain T S C A CB1 1245 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fx MALE RATS GROUP : VII-1 DOSE : 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1 8 15 22 29 36 42.6 41.3 40.0 40.8 50.7 50.7 52.4 48.5 51.2 46.5 43.4 55.7 86.3 91.5 96.7 82.1 96.4 85.3 87.4 83.9 84.8 80.3 80.5 100.9 137.5 144.5 170.4 139.6 158.8 143.5 143.3 139.6 131.4 135.8 133.4 155.8 203.2 211.9 224.0 197.3 221.1 200.7 209.1 210.9 190.5 202.0 187.0 214.3 258.8 272.7 344.6 252.2 281.3 255.5 259.0 242.8 239.8 270.4 245.1 246.2 318.3 331.9 417.0 280.9 296.9 275.0 318.9 265.3 299.5 277.7 313.3 327.4 Company Sanitized. Does not contain T SC A CB1 1246 H-24516: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fj FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 1 8 15 22 29 36 59.3 59.1 67.4 62.0 55.1 45.9 60.5 50.3 46.5 63.1 58.4 58.5 58.3 96.0 103.1 103.8 99.6 96.4 84.1 93.2 85.0 78.1 95.5 102.2 94.0 91.4 130.3 139.6 136.8 143.7 144.1 132.3 139.9 122.5 121.7 137.1 156.4 135.0 126.3 156.9 160.9 152.2 180.4 185.9 163.3 179.6 158.2 155.0 181.8 185.8 167.0 150.2 177.1 182.7 170.8 199.8 204.7 192.7 207.7 173.2 176.8 210.2 217.7 194.6 161.6 203.4 201.4 179.7 221.4 219.6 212.8 219.6 200.7 191.0 211.6 231.0 213.7 176.7 Company Sanitized. Does not contain T SC A CBI 1247 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fi FEMALE RATS GROUP : IV-1 DOSE : 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 1 8 15 22 29 36 61.4 58.5 63.9 56.3 54.5 65.1 59.1 59.9 69.0 60.5 44.8 58.4 67.0 56.5 46.7 56.0 59.0 91.7 97.0 98.2 96.0 92.1 106.5 98.1 99.4 108.8 100.3 77.6 95.5 99.0 87.9 79.5 86.7 97.5 138.6 143.9 137.7 146.2 141.0 158.4 150.9 145.1 171.7 140.9 114.8 137.8 137.1 124.0 120.6 123.3 140.4 161.4 186.5 168.8 181.1 176.9 212.3 196.4 180.0 220.4 162.9 137.3 171.9 171.9 155.7 150.5 151.1 168.3 186.1 204.9 192.1 209.8 201.1 246.4 223.6 191.4 232.3 171.7 146.5 195.8 200.7 174.7 172.1 180.4 196.1 _a 223.5 206.5 228.5 223.2 283.9 242.1 203.7 280.7 197.7 164.9 222.7 218.1 196.8 192.7 196.2 219.3 Company Sanitized. Does not contain T SC A CB! 1248 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fj FEMALE RATS GROUP; VI-1 DOSE; 100 MG/KG/DAY DAYS ON TEST; ANIMAL NUMBER 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 1 8 15 22 29 36 65.7 52.1 53.1 59.0 55.8 62.5 54.3 60.4 51.5 49.3 56.1 60.1 101.8 88.9 90.3 91.5 96.1 84.0 86.5 97.6 87.6 77.8 84.3 98.2 143.2 135.5 131.5 125.9 138.5 142.2 132.0 141.8 130.8 117.1 123.9 141.0 167.7 166.5 164.1 161.1 177.8 184.3 166.2 177.2 170.3 142.0 160.1 173.0 193.1 194.3 185.0 167.7 211.5 209.8 190.3 204.7 200.8 159.8 181.8 198.3 213.2 215.3 206.8 194.1 235.8 235.6 215.2 222.1 219.3 173.7 196.9 222.9 Company Sanitized. Does not contain T SC A CB1 1249 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHTS (grams) OF Fj. FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 1 8 15 22 29 36 58.4 39.7 27.9 35.8 47.6 45.2 45.6 49.0 52.2 43.6 40.4 51.5 97.2 88.5 68.1 70.4 78.5 76.6 77.8 80.2 84.9 69.1 73.8 94.5 142.1 124.3 117.6 113.2 125.8 123.3 118.3 124.3 127.3 115.4 124.6 141.4 176.2 157.1 166.1 143.3 167.8 162.1 153.4 157.1 157.0 158.3 163.2 178.9 203.5 190.5 210.4 170.6 190.7 189.6 164.3 183.4 173.4 186.7 190.3 199.1 197.3 194.5 238.3 193.8 219.7 209.0 187.7 210.1 206.9 217.1 202.0 198.8 Company Sanitized. Does not contain TSCACB\ 1250 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX JJ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION Company Sanitized. Does not contain TSCA CBI 1251 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: Fi GENERATION EXPLANATORY NOTES DuPont-5386 Notes Day of weaning = Test Day 1. a No data due to weighing error. jmpany Sanitized. Does not contain TSC A CBI 1252 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL BODY WEIGHT GAINS (grams) OF F x MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DuPont-5386 DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1-8 8-15 15-22 22-29 29-36 1-36 40.5 57.6 44.8 56.5 50.4 45.2 43.5 40.8 39.7 47.2 41.6 35.5 46.0 53.3 75.6 64.8 71.0 66.8 61.3 69.2 55.8 59.3 65.5 66.5 63.6 53.3 47.5 71.7 66.0 63.1 61.7 57.7 73.6 61.2 65.3 70.7 59.7 69.9 65.2 47.7 73.2 61.4 72.5 64.3 51.9 75.4 41.4 60.9 32.0 46.6 73.9 58.3 52.2 59.0 16.4 -2.9 59.2 59.8 -11.1 66.0 5.5 83.9 75.5 23.3 16.4 241.2 337.1 253.4 260.2 302.4 275.9 250.6 265.2 230.7 299.3 289.9 266.2 239.2 iinpany Sanitized. Does not contain T SC A CBI 1253 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1-8 8-15 15-22 22-29 29-36 1-36 38 .7 45 ,3 35 .,2 41 .2 45..4 41 .2 40 .2 46 ,.9 49 .9 42 .2 40..0 47 ,.0 38 .6 31..2 35 .7 44 ,.7 70 ,.2 63 ,.7 55 .5 59 .2 63 ,.0 58 .0 64 ,.8 61..4 64 .7 62 .9 61 .2 62 ,.1 61..0 45 .3 49 .9 56 .8 54 .4 64 .2 54 .4 58 .2 59 .3 68..6 67..8 69,.0 54 ,.9 55 ,.0 58 .9 60..9 64 .7 53 .0 62 ,.2 55 ,.4 70 ,.8 46..2 65..0 61 .4 64 .4 14 .7 25..3 55..8 76 .8 54 .7 56,.1 76 .9 50 ,.1 50 .6 54 .6 52 .4 a 61 .3 26 .3 60 .3 58 .2 94 .2 23 .4 70 .5 64 .0 55 .8 22 .0 67 .5 32 .7 54 .6 62 .1 66 .3 _a 280 .7 236 ,.4 280 .3 290 .3 276 .7 221 ,.5 303 .6 310 .3 270 ,.6 238 .2 314 .4 247 .1 234 .7 264 .5 275 ,.6 ompany Sanitized. Does not contain T SC A CBI 1254 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fj MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 39.1 40.7 33.6 48.1 42.2 45.8 38.1 43.8 42.7 38.6 41.0 49.2 52.2 57.2 53.5 66.9 68.8 62.2 60.9 65.3 61.6 56.3 60.3 64.2 65.8 62.6 68.2 63.3 53.5 62.5 64.4 62.5 67.6 59.4 58.4 52.2 46.8 66.9 29.2 70.9 81.1 36.2 57.4 37.6 61.4 63.9 65.3 58.7 12.2 18.7 26.4 67.2 73.3 31.7 20.2 29.9 13.5 26.1 24.7 30.6 216.1 246.1 210.9 316.4 318.9 238.4 241.0 239.1 246.8 244.3 249.7 254.9 ompany Sanitized. Does noi conlaln T S C A C B I 1255 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1-8 8-15 15-22 22-29 29-36 1-36 43.7 50.2 56.7 41.3 45.7 34.6 35.0 35.4 33.6 33.8 37.1 45.2 51.2 53.0 73.7 57.5 62.4 58.2 55.9 55.7 46.6 55.5 52.9 54.9 65.7 67 .4 53.6 57.7 62.3 57.2 65.8 71.3 59.1 66.2 53.6 58.5 55.6 60.8 120.6 54.9 60.2 54.8 49.9 31.9 49.3 68.4 58.1 31.9 59.5 59.2 72.4 28.7 15.6 19.5 59.9 22.5 59.7 7.3 68.2 81.2 275.7 290.6 377.0 240.1 246.2 224.3 266.5 216.8 248.3 231.2 269.9 271.7 ompany Sanitized. Does not contain T SC A CBI 1256 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 1-8 8-15 15-22 22-29 29-36 1-36 36.7 44.0 36.4 37.6 41.3 38.2 32.7 34.7 31.6 32.4 43.8 35.5 33.1 34.3 36.5 33.0 44.1 47.7 48.2 46.7 37.5 43.6 41.6 54.2 41.0 34.9 26.6 21.3 15.4 36.7 41.8 31.0 39.7 35.7 33.3 44.7 29.4 32.0 23.9 20.2 21.8 18.6 19.4 18.8 29.4 28.1 15.0 21.8 28.4 31.9 27.6 11.4 26.3 18.7 8.9 21.6 14.9 20.1 11.9 27.5 14.2 1.4 13.3 19.1 15.1 144.1 142.3 112.3 159.4 164.5 166.9 159.1 150.4 144.5 148.5 172.6 155.2 118.4 iompany Sanitized. Does not contain TSCACW 1257 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F 1 FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 1-8 8-15 15-22 22-29 29-36 1-36 30.3 38.5 34.3 39.7 37.6 41.4 39.0 39.5 39.8 39.8 32.8 37.1 32.0 31.4 32.8 30.7 38.5 46.9 46.9 39.5 50.2 48.9 51.9 52.8 45.7 62.9 40.6 37.2 42.3 38.1 36.1 41.1 36.6 42.9 22.8 42.6 31.1 34.9 35.9 53.9 45.5 34.9 48.7 22.0 22.5 34.1 34.8 31.7 29.9 27.8 27.9 24.7 18.4 23.3 28.7 24.2 34.1 27.2 11.4 11.9 8.8 9.2 23.9 28.8 19.0 21.6 29.3 27.8 _a 18.6 14.4 18.7 22.1 37.5 18.5 12.3 48.4 26.0 18.4 26.9 17.4 22.1 20.6 15.8 23.2 _a 165.0 142.6 172.2 168.7 218.8 183.0 143.8 211.7 137.2 120.1 164.3 151.1 140.3 146.0 140.2 160.3 Company Sanitized. Does not contain T SC A CBI 1258 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fx FEMALE RATS GROUP: V I -1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 36.1 36.8 37.2 32.5 40.3 21.5 32.2 37.2 36.1 28.5 28.2 38.1 41.4 46.6 41.2 34.4 42.4 58.2 45.5 44.2 43.2 39.3 39.6 42.8 24.5 31.0 32.6 35.2 39.3 42.1 34.2 35.4 39.5 24.9 36.2 32.0 25.4 27.8 20.9 6.6 33.7 25.5 24.1 27.5 30.5 17.8 21.7 25.3 20.1 21.0 21.8 26.4 24.3 25.8 24.9 17.4 18.5 13.9 15.1 24.6 147.5 163.2 153.7 135.1 180.0 173.. 1 160.9 161.7 167.8 124.4 140.8 162.8 Company Sanitized. Does not contain T SC A CBI 1259 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: .ANIMAL N U M BE R 1-8 8-15 15-22 22-29 29-36 1-36 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 38.8 48.8 40.2 34.6 30.9 31.4 32.2 31.2 32.7 25.5 33.4 43.0 44.9 35.8 49.5 42.8 47.3 46.7 40.5 44.1 42.4 46.3 50.8 46.9 34.1 32.8 48.5 30.1 42.0 38.8 35.1 32.8 29.7 42.9 38.6 37.5 27.3 33.4 44.3 27.3 2 2 .9 27.5 1 0 .9 26.3 16.4 28.4 27.1 20.2 -6.2 4.0 27.9 23.2 29.0 19.4 23.4 26.7 33.5 30.4 1 1 .7 -0.3 138.9 154.8 210.4 158.0 172.1 163.8 142.1 161.1 154.7 173.5 161.6 147.3 Company Sanitized. Does not contain T SC A CB\ 1260 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX KK REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: Fi GENERATION Company Sanitized. Does not contain T S C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. DuPont-5386 Company Sanitized. Does not contain T S C A CB! 1262 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F 1 MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 1-8 8-15 15-:22 22- 29 29- 36 1-;36 12 .3 15 .2 12 .7 15 .3 12 .6 14 .4 12 .0 12 .7 11..0 13 .5 12 .0 11..1 12 .,0 20..5 22 .8 20..1 23 .6 20 .0 18 .8 20 ,.6 18 .7 18 .2 19 .6 20 .3 18 .6 18 .0 20 .4 27 .3 25 .1 27 .1 23 .6 23 .3 25 .1 22 .7 22 .9 25 .5 23 .7 24 .1 23 .8 22 .9 30 .3 26 .7 31 .1 26 .1 24 .8 30 .3 23 .9 27 .8 25 .0 25 .6 29 .5 27 .0 25 .6 9 .2 26 .1 24 .4 10 .2 9 .5 21 .8 12 .8 23 .3 30 .9 31 .0 26 .2 25 .8 20 .3 21 .0 22 .2 24 .3 18 .5 18 .2 22 .0 18 .2 20 .6 22 .9 22 .5 21 .9 21 .4 Company Sanitized. Does no! contain TSC A CB\ 1263 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 1-8 8-15 15-:22 22-:29 29- 36 1-:36 11..5 11 .9 11..7 11..0 11..5 13 .2 12 .2 13 .3 14 .1 12 .2 11..8 14 .,1 11..9 9.,8 10 .9 14 .0 19..4 19 .6 18 .0 17 .2 18 .1 19 .2 19 .3 20 .1 20 .,4 18 .9 18 .8 21..2 19 ..6 15 .1 15 .3 19 .0 23 .5 23 .1 21 .8 21 .4 22 .7 24 .6 24 .9 24 .5 25 .0 22 .0 21 .9 24 .6 25 .0 19 .8 20 .6 22 .2 26 .7 24 .3 25 .0 25 .7 25 .6 21 .6 24 .1 28 .1 28 .8 22 .7 23 .8 31 .2 25 .4 22 .5 22 .8 24 .7 46 .6 26 .5 24 .0 2 .3 7 .8 28 .6 22 .8 31 .1 28 .5 25 .9 22 .9 14 .4 25 .2 25 .2 25 .4 15 .5 25 .5 21 .1 20 .1 15 .5 17 .1 21 .4 20 .7 23 .4 23 .4 20 .3 19 .8 21 .1 21 .4 18 .5 19 .0 19 .1 ompany Sanitized. Does not contain TSC A CB1 1264 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fj MALE RATS GROUP : V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 1-8 8-15 15-22 22-29 29-36 1-36 10.7 11.6 9.6 13.7 12.0 12.4 11.5 12.9 11.1 11.3 11.6 15.6 16.9 18.6 17.4 20.9 20.6 20.9 19.1 20.6 18.4 17.1 18.7 21.2 21.7 24.4 24.9 26.0 24.2 25.9 25.2 24.7 24.4 21.8 23.3 22.8 25.0 29.4 26.0 29.3 30.2 26.1 28.2 26.2 29.5 26.3 27.2 24.5 21.1 25.7 23.5 17.7 15.4 27.2 25.2 25.4 24.6 24.9 26.2 25.5 19.1 21.9 20.3 21.5 20.5 22.5 21.8 22.0 21.6 20.3 21.4 21.9 Company Sanitized. Does not contain T SC A CB1 1265 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 1-8 8-15 15-22 22- 29 29- 36 1- 36 12 .0 12 .8 12 .5 10 .9 12..9 10,.3 11..0 10 .3 11..2 11..2 10..1 12..8 18 .0 15..0 19 .4 16 .9 19 ,.5 16 .8 17 ,.9 17..3 17 .2 15 ,.7 16 .2 18 .5 23 .4 22 .4 24 .7 20 .8 25 ,.3 21 .6 23 .3 24..5 21..4 23 ,.2 20 .1 22 ,.4 26 .0 28 .1 34 .5 24 .1 28 .7 24 .3 26 .0 24 .7 24 .8 27 .4 23 .6 22 .7 28 .0 4 .2 8 .1 23 .0 24 .2 23 .9 28 .3 23 .5 25 .7 24 .7 26 .5 28 .0 21 .5 16 .5 19 .8 19 .1 22 .2 19 .4 21 .3 20 .1 20 .1 20 .4 19 .3 20 .9 Company Sanitized. Does not contain T SC A CB1 1266 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fi FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1--8 8- 15 15-:22 22-:29 29-:36 1-:36 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 12 .1 12 .5 11,.2 11 .0 11 .9 11,.4 10 ,.8 12 .,4 9 .6 11,.0 13 ,.2 11,.4 11,.0 16 .1 17 .1 15 .8 15 .6 16 .9 16 .3 16 .6 15 .3 15 .4 15 .5 20 .9 17 .0 15 .2 18 .6 16 .6 15 .4 17 .5 18 .6 17 .7 20 .1 17 .9 17 .7 18 .3 18 .9 17 .7 16 .3 18 .5 17 .1 14 .9 17 .9 18 .7 18 .8 20 .1 16 .7 17 .2 20 .6 20 .9 18 .3 16 .0 19 .5 17 .7 15 .4 17 .8 18 .5 18 .5 18 .5 17 .4 17 .3 17 .8 20 .4 18 .3 15 .5 17 .0 16 .2 14 .6 16 .0 16 .9 16 .5 17 .2 15 .9 15 .5 16 .6 18 .9 16 .6 14 .8 Company Sanitized. Does no! contain T SC A C B I 1267 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fj. FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 9 ,.9 12 .8 12 .2 11 .6 10 .9 13 ,.3 11 .6 12 .3 12 .3 13 .1 9 .0 11 .8 10 .5 10 .7 10 .2 10 ,.8 11..9 16 .8 16 .9 16 .4 16 .2 15 .4 19..3 18 .4 16 .1 20 ,.2 18 ,.2 13 .7 17 .1 16..3 14 .9 15 .4 15 .1 16,.7 17 .3 19 .9 17 .4 18,.4 18 ,.3 23 .4 22 .4 17..4 23 .3 17 ,.2 14 .9 19..9 17 .3 16 .6 16 .3 15..8 17..0 17 ,.3 18 .1 17 .4 19 ,.7 18 ,.2 23 .0 21 .5 16 ,.9 22 ,.3 16..2 14 .4 20 .2 18 .1 15 ,.8 16 .8 16 .8 17 .6 46..8 19 ,.4 17 ,.2 20 ,.4 18 ,.8 25 .9 23 .7 14 .7 27 .0 18 .0 15..5 22 ..5 17 .3 15..4 17..2 16 ,.6 18 .1 21..6 17..4 16 ,.1 17 .3 16 .3 21,.-o 19 .5 15..5 21..0 16 ,.5 13 .5 18 .,3 15 .9 14..7 15..2 15 .0 16 .2 Company Sanitized. Does not contain T SC A CBI 1268 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fx FEMALE RATS GROUP: V I -1 DOSE: 100 MG/KG/DAY DAYS ON TEST: .ANIMAL NUMBER 1-8 8-15 15-22 22-29 29-36 1-36 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 11 .4 11 .7 11..1 10 .7 12 ,.8 7 .9 10 ,.5 13 .5 13 ,.1 9..4 9 .4 11..7 15 .7 16..3 16..6 14 .3 16 .0 18 .3 16 ,.4 17 ,.7 16 .2 15..6 15 .1 18 .4 16 ,.5 17..7 19..8 17..0 18..5 19..9 19 .5 19 .7 19 .6 15.,5 16 .9 20 .,9 16 .8 19 .0 19..5 16 ,.1 20 .1 21,.3 20 ,.3 19 .6 19 .7 15.,8 17 .5 21..5 17..7 19 .4 19 .9 16 .0 19 .8 21,.5 19 ,.7 20 ,.2 19 .9 15 .6 17 .1 20 .9 15 .6 16 ,.8 17 .4 14 ,.8 17 .5 17 .8 17 .3 18 ,.1 17 .7 14 .4 15 ,.2 18 .7 Company Sanitized. Does not contain T SC A CB! 1269 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fa FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 1-8 8-15 15-22 22-29 29-36 1-36 12 .0 12 .8 10 .2 9 .7 10 .2 9 .6 10 .6 9 .6 11,.3 8 .5 9 .0 12 .2 17..7 15..7 14..8 14 .6 15 .1 14 .5 14 .9 16 .0 16 .8 14 ,.5 16 .5 18 .5 18 ,.5 17 .6 18 .6 16 .6 18 .6 17 .5 17 ,.2 17 .2 16..4 12 .0 19 .6 19 ,.6 19 ,.8 19 ,.8 19 .5 17 .5 19..4 17 .6 17 .1 18 .0 16 .7 18 .9 19 .0 20 .5 16 .5 14 .2 19 ,.4 18 ,.4 19 .8 17 ,.9 17 .0 .18 .9 18 .3 19 .6 20 .2 17 .5 16 .9 16 .0 16 ,.5 15 ,.4 16 .6 15 .4 15 .4 15 ,.9 15..9 14..7 16 .9 17..7 Company Sanitized. Does not contain T S C A CBl 1270 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX LL REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: F, GENERATION ompany Sa ,, te e d . Does not ,, m a in TSCA C B I 1271 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-5386 REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: Fj GENERATION EXPLANATORY NOTES Notes Day o f weaning = Test Day 1. Company Sanitized. Does not contain T SC A CB1 1272 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Fi M A L E R A T S GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D BY DE S I G N TES T DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 19 19 19 19 18 18 20 20 19 19 19 19 19 19 19 19 20 20 20 20 20 20 27 27 20 20 Company Sanitized. Does no! contain TSC A CB1 1273 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S I N Fi M A L E R A T S GROUP: III-l DOSE: 25 MG/KG / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 14 14 20 20 21 21 21 21 21 21 22 22 20 20 23 23 24 24 21 21 22 22 20 20 20 20 27 27 26 26 22 22 Company Sanitized. Does not contain T S C A CBf 1274 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Pi M A L E R A T S GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 PREPUTIAL SEPARATION COMPLETE S A CRIFICED BY DE S I G N T E S T DA Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESI G N TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRI F I C E D B Y D E S I G N T E S T D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY D E S I G N TES T D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D BY D E S I G N T E S T D AY 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D BY D E S I G N T E S T D AY 40 PREPUTIAL SEPARATION COMPLETE SACR I F I C E D BY D E S I G N T E S T D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY D E S I G N TES T DA Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S A CRIFICED BY DE S I G N T E S T DA Y 40 20 20 25 25 29 29 20 20 23 23 22 22 27 27 20 20 23 23 27 27 20 20 22 22 Company Sanitized. Does not contain TSC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Fi M A L E R A T S GROUP: VII-1 DOSE: 250 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED B Y DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S A C R I F I C E D BY DE S I G N T EST D A Y 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE S ACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 24 24 21 21 20 20 24 24 23 23 20 20 21 21 23 23 24 24 24 24 27 27 21 21 Company Sanitized. Does not contain TSC A CB\ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Fi F E M A L E R A T S GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 VAGINAL PATENCY COMPLETE SACR I F I C E D BY D E S I G N T E S T D A Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E S I G N T E S T D A Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACR I F I C E D BY D E S I G N T E S T DA Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TE S T DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S A CRIFICED B Y DE S I G N T E S T D A Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST D AY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY DE S I G N T EST D A Y 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY D E S I G N T E S T D A Y 40 88 10 10 99 14 14 12 12 12 12 13 13 13 13 12 12 18 18 12 12 12 12 12 12 CompanySanitized. Does not contain TSCA C B I 1277 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Fj. F E M A L E R A T S GROUP: IV-1 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESI G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE S ACRIFICED BY D E S I G N TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 11 11 19 19 12 12 15 15 13 13 11 11 12 12 13 13 40 40 11 11 11 11 88 13 13 12 12 11 11 11 11 13 13 Company Sanitized. Does not contain T SC A C B I 1278 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL CLINICAL OBSERVATIONS IN Fi FEMALE RATS GROUP: V I -1 DOSE: 100 MG/KG/DAY DuPont-5386 ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED B Y DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE S A C R I F I C E D BY D E S I G N T EST D AY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 17 17 11 11 10 10 12 12 14 14 12 12 13 13 11 11 12 12 11 11 10 10 Company Sanitized. Does not contain T S C A C B l 1279 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 I N D I V I D U A L C L I N I C A L O B S E R V A T I O N S IN Fi F E M A L E R A T S G R O U P : V I I I -1 DOSE: 250 MG/KG/DAY .ANIMAL N U M B E R OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY D E SIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 10 10 11 11 20 20 11 11 13 13 12 12 12 12 12 12 12 12 14 14 12 12 11 11 Company Sanitized. Does not contain T SC A CBl 1280