Document aQ4Yz5KDog6BnqJG9Ng4r7DR

H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations AR226-3198 DuPont-5368 TRADE SECRET Study Title H -24516: Sbchronic Toxicity - 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 2 o f 5 Laboratory Project ID : DuPont-5386 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Gregory S. Ladies, Ph.D ., D.A.B.T. Study Completed on: December 3,2001 Performing Laboratory: E.I. du Pont de N em ours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number: 3 Service Code Number: Sponsor Study Number: Page 317 of 1500 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS I LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. (10) (10) (10) (ID 643272 643311 643259 643260 643309 643143 643173 643224 643174 643150 643179 643243 643193 643185 643180 643247 643194 643189 643228 643250 643201 643204 643240 643257 643215 643205 643264 643275 643252 643235 643290 643311 643259 643241 643292 643314 643260 643288 643308 643318 643298 643300 643315 643175 643174 643224 643193 643243 643194 643247 643201 643257 643215 643275 643252 643311 643259 643314 643260 643318 643298 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 318 Company SanWzed. Oses no! contain TSC CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII LIVER HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, CENTRILOBULAR. (10) (10) (10) (11) 643309 643315 643189 643180 643250 643300 643264 643257 643189 643180 643224 643174 643290 643243 643259 643257 643309 643275 643311 643318 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 319 Oempany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII PANCREAS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. ATROPHY. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643241 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643260 643298 643309 643315 643252 643259 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 320 otttpisnjp Sanitized. D ees not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS i LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED ' INFLAMMATION, SUBACUTE/CHRONIC. EDEMA. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643174 643193 643194 643201 643215 643252 643260 643298 643315 643175 643259 643309 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 321 Comparty Sanitized. Does not contain TSCA CM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII STOMACH NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 322 Conii*iny SsfiWzsff, Does no! contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III 'V VII DUODENUM NO ABNORMALITY DETECTED ' (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 323 Company SanRteed. Does no! contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) " TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII JEJUNUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 324 Conmany San*t!zed. Doe* no* contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII ILEUM NO ABNORMALITY DETECTED (10)' 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 325 Comoany Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII CECUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 326 Comnany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII COLON NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (ID 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 327 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM i LESION INCIDENCE (NUMERIC) TREATMENT (mq/kg/day) 0 I 25 100 III >v 250 VII RECTUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 328 Sonipanjr Sanitised. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | LESION INCIDENCE (NUMERIC) 1 O 11 1 1 1 TREATMENT (mg/kg/day) H 25 100 250 III V VII SALIVARY GLANDS NO ABNORMALITY DETECTED - (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 329 Company Sanitized. Does not contain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. HYPERTROPHY, TUBULAR. (10) (10) (10) (11) 643143 643173 643224 643185 643179 643243 643189 643240 643250 643205 643264 643257 643235 643272 643318 643288 643290 643308 643150 643180 643175 643193 643204 643228 643247 643194 643241 643292 643311 643215 643300 643314 643252 643298 643309 643275 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 330 omPaft5r Sanlffeed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII URINARY SYSTEM KIDNEYS HYPERTROPHY, TUBULAR. HYDRONEPHROSIS, UNILATERAL. HYDRONEPHROSIS, BILATERAL. (10) (10) (10) (11) 643315 643259 643174 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 331 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS URINARY SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII URINARY BLADDER NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 332 Cnmnoov fkM* not contain TSCA CBt H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III 'V VII RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. INFLAMMATION, GRANULOMATOUS. (10) 643143 643150 643185 643189 643235 643241 643288 643300 643204 643205 (1) (11) 643174 643194 643201 643215 643252 643259 643298 643315 643260 643309 643175 643193 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 333 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | LESION INCIDENCE (NUMERIC) 1 i 1 1o w 1 TREATMENT (mg/kg/day) 25 100 250 III V VII TRACHEA NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 334 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII PHARYNX/LARYNX (10) (1) (11) NO ABNORMALITY DETECTED 643143 643175 643174 643150 643193 643185 643194 643189 643201 643204 643215 643205 643252 643235 643259 643241 643260 643288 643298 643300 643315 HEMORRHAGE. 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 335 Company Sanitized. Does not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM. DEGENERATION, AMELOBLASTS. (10) (10) (10) (ID 643143 643173 643224 643150 643179 643243 643185 643180 643250 643189 643228 643314 643204 643240 643205 643264 643235 643272 643241 643290 643288 643292 643300 643308 643175 643201 643309 643309 643315 643175 643247 643174 643257 643193 643275 643194 643311 643201 643318 643215 643252 643259 643260 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 336 Company Sanitized. Does not contain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII NOSE DEGENERATION, AMELOBLASTS. (10) (10) (10) (11) 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 337 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII HEART NO ABNORMALITY DETECTED CARDIOMYOPATHY. INFLAMMATION, SUBACUTE/CHRONIC. (10) 643143 643150 643185 643241 643288 643189 643204 643205 643235 643300 (1) ' (ID 643174 643193 643201 643215 643252 643260 643298 643309 643194 643259 643315 643175 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 338 Company SanRfeed. Does no! confata TSCA CB! H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII AORTA NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 339 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII SPLEEN NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 340 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED ATROPHY. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 341 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III y VII MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (U (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 342 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 343 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII BONE MARROW NO ABNORMALITY DETECTED - HYPERPLASIA, GRANULOCYTIC. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 643175 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 344 Company Sanitized Does not oonta'n TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII PITUITARY GLAND NO ABNORMALITY DETECTED (10) 643143 (1) (11) 643175 643174 643150 643193 643185 643194 643189 643201 643204 643215 643205 643252 643235 643259 643241 643260 643288 643298 643300 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 345 Company Sanitized. Boss not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. (10) (10) (10) (11) 643150 643179 643175 643235 643224 643174 643318 643193 643194 643201 643252 643259 643260 643298 643309 643315 643143 643173 643224 643174 643185 643180 643243 643193 643189 643228 643247 643194 643204 643240 643250 643201 643205 643264 643257 643215 643235 643272 643275 643252 643241 643290 643311 643259 643288 643292 643314 643260 643300 643308 643318 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 346 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM TREATMENT (mg/.kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII PARATHYROID GLANDS NO ABNORMALITY DETECTED (8) 643143 643150 643185 643204 643205 643235 643241 643300 (10) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 347 OBipany Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII ADRENAL GLANDS NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 348 Company Sanitized. Does not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII BRAIN NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 349 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII SPINAL CORD NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 350 Cw**pany Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) TREATMENT 0 (mg/kg/day). I 25 100 250 III V VII NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (1 0 ) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 351 Company Sanitized. Does not contain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 352 Company Sanitized. Does not contain TSCCM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ................ ... ................ -- ---- DuPont-5368 ----- ---------------------- TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure"in~parentheses is number of animals microscopically g][ehis tlSSUS The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 354 Company Sanitized. Does not contain TSCA CEIf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 -------- TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII MUSCULAR AND SKELETAL SYSTEM MANDIBLE NO ABNORMALITY DETECTED DEGENERATION, AMELOBLASTS. (10) (10) (9) 643143 643173 643224 643150 643179 643243 643185 643180 643247 643189 643228 643250 643204 643240 643257 643205 643264 643311 643235 643272 643314 643241 643290 643318 (10) 643288 643292 643300 643308 643275 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 355 Company SanWzed. Does not contain TSCACBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED SPERMATID RETENTION, SEMINIFEROUS TUBULES. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 643175 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 356 eempany Sanitized. Pees net eontain TSCACB! TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATIO ) LESIONS | LESION TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII REPRODUCTIVE SYSTEM EPIDIDYMIDES NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Gompanf Sanitized. Does not contain TSCACW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643300 643288 (1) (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643175 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 358 Company Sanitized. Does not contain TSCCW H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII REPRODUCTIVE SYSTEM SEMINAL VESICLES NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 359 Company San*f**ed. Does motcontain TSCA GB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 360 Comoany SanWzed. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) .......... .... LESION INCIDENCE (NUMERIC) LESIONS TREATMENT (mg/kg/day) 25 100 250 III V VII SPECIAL SENSES SYSTEM E Y E (S) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT. FOLD/ROSETTE, RETINAL. (10 ) 643143 643150 643185 643189 643204 643235 643241 643288 643300 643205 (1 ) (1 1 ) 643175 643174 643194 643201 643215 643252 643259 643260 643298 643315 643252 643309 643193 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 361 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII DIGESTIVE SYSTEM LIVER NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. (10) (10) 643316 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643296 643303 643316 643304 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 362 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDINCE (NUMERIC) Males TREATMENT (mg/kg/day) 250 VII 1 1 1 1 O H1 1 DIGESTIVE SYSTEM LIVER FOCUS OF CELLULAR ALTERATION, BASOPHILIC. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, CENTRILOBULAR. (10) (10) 643151 643253 643316 643246 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 363 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. HYPERTROPHY, TUBULAR. HYDRONEPHROSIS, UNILATERAL. LESION INCIDIINCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII (10) (10) 643162 643165 643172 643220 643262 643225 643303 643258 643304 643296 643195 643234 643226 643236 643237 643266 643246 643316 643253 643151 643266 643234 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 364 eumany SanWzed. Does no! contain TSCA 08f H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED ODONTODYSPLASIA. DEGENERATION, AMELOBLASTS. (1 0 ) ( 10) 643172 643266 643195 643226 643237 643246 643253 643262 643303 643304 643162 643151 643165 643220 643225 643234 643236 643258 643296 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 365 Company Sanitized. Does not contain TSCACBt H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED THYMUS NO ABNORMALITY DETECTED MANDIBULAR LYMPH NODE ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS. LESION INCIDENCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII (l) 643304 (1) (1) 643304 643236 (1) 643304 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 366 'Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDE NCE (NUMERIC) Males TREATMENT (mg/kg/day) 250 VII 1 1 1 1 O Hl i ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. (10) (10) 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643266 643303 643296 643304 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 367 Company SanWzed D ow not contain TSCACBf t H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations IIP DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII MUSCULAR AND SKELETAL SYSTEM MANDIBLE NO ABNORMALITY DETECTED (10) (10) 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643266 643303 643296 643304 643316 is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 368 eomBanirS*nt9e<f. D oes no! contain TSCA CBV H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDI]NCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I 250 VII REPRODUCTIVE SYSTEM TESTES DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL. DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL. EPIDIDYMIDES NO ABNORMALITY DETECTED OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL. SEMINAL VESICLES NO ABNORMALITY DETECTED (2 ) ( 1) 643226 643253 643220 (2 ) (X) 643226 643253 643220 (1 ) 643220 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 369 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM LIVER NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, CENTRILOBULAR. | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII (5) 643210 643145 643210 643232 643265 643268 643232 (5) (5) 643169 643283 643206 643159 643149 643169 643152 643181 643178 643206 643283 643286 643295 643152 643149 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 370 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED CALCULUS\CALCULI. NEPHROPATHY, CHRONIC PROGRESSIVE. INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA, TRANSITIONAL CELL. TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII (5) 643232 643265 643145 643210 643268 (5) 643149 643152 643178 643283 643295 643149 643149 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 371 Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS 1 LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT. INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM. FRACTURE/CALLUS, TOOTH. DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM. DEGENERATION, AMELOBLASTS. SCHWANNOMA [B]. (5) (5) (5) (5) 643210 643306 643169 643232 643206 643265 643286 643305 643181 643145 643202 643159 643149 643268 643293 643181 643178 643310 643283 643295 643145 643202 643159 643149 643268 643181 643202 643178 643293 643283 643310 643159 643295 643159 643152 643295 643202 [B] Benign tumour ,. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 372 Company Sanitized Does not contain TSCA CB1 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII THYROID GLAND ALTERATION, COLLOID. (5) (5) (5) (5) 643145 643202 643159 643149 643210 643293 643169 643152 643232 643305 643181 643178 643265 643306 643206 643283 643268 643310 643286 643295 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 373 Company Sanitized. Does no* contain TSCACBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESIOI> INCIDEINCE (NtIMERIC) 0 25 100 250 II IV VI VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. - HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. (10) (10) (10) (11) 643354 643321 643322 643340 643368 643362 643489 643361 643324 643323 643359 643362 643364 643366 643370 643374 643380 643367 643404 643398 643389 643392 643408 643406 643390 643409 643435 643436 643396 643461 643446 643463 643410 643462 643466 643477 643433 643472 643486 643458 643489 643332 643341 643359 643370 643404 643408 643435 643446 643466 643374 643458 N=ll in Group VIII reflects one reproduction designated animal that died on test day 53. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 374 *e" n P"V8anllked. Does notcontain tscacbi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII LIVER FATTY CHANGE, MEDIAN CLEFT. PANCREAS NO ABNORMA'LITY DETECTED ATROPHY. (10) (10) 643398 (10) (11) (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643466 643435 643446 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 375 Oompany Sanitized. Does not contain TSCA CBt H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) M ICROSCOPIC OBSERVATIONS IN FfEM ALE RATS LISTING INDIVIDUAL ANIM ALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 II 25 100 250 IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 376 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS i LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 Fiqure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ...... (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 __ _____ 377 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED ' | LESION INCIDENCE (NUMERIC) i 1l 1H 1O H 1 TREATMENT (mg/kg/day) 25 100 250 IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 378 Company SsniPzed, Coes no! confata TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. i ... -- i 11 11 |1 1 H1 1I O H I1 | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 25 100 250 IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 643340 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 379 Company Sanitized. Does not contain TSCA CB! H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) 1 O1 I1 1 .1- 1I TREATMENT (mg/kg/day) 25 100 250 IV VI VIII H H DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined f:or this tissue The absence of a number indicates the lesion specified was not identified 380 Sanitized. Does not contain TSCACBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED | LESION INCIDENCE (NUMERIC) 1 1 1 1H 1O H 1 TREATMENT (mg/kg/day) 25 100 250 IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 381 Company Sanitized. Does not contain TSCACBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) .1 --.... . 1 1 1 lH 1O H 11 LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 25 100 250 IV >VI VIII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure, in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 382 ftampany Sanitized. Doe* not contain TSCA Cffl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS i LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 383 .m .M . floes tie* coefafn TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE' SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) (11) 643354 643321 643332 643361 643340 , 643362 643341 643374 643359 643398 643368 643406 643370 643436 643404 643463 643408 643477 643435 643486 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 384 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. NECROSIS, TUBULAR. INFLAMMATION, ACUTE. INFARCT. HYPERPLASIA, TRANSITIONAL CELL. HYDRONEPHROSIS, BILATERAL. CYST. AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. 1 LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII (10) (10) (10) (11) 643354 643324 643322 643332 643361 643380 643366 643340 643374 643389 643367 643341 643406 643390 643409 643359 643463 643410 643461 643368 643486 643433 643462 643435 643458 643472 643446 643362 643364 643323 643370 643398 643396 643392 643404 643477 643489 643408 643466 643321 643321 643370 643321 &43321 643436 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 385 Company Sanitized Does no! contain TSCA CB H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED HYPERPLASIA, SIMPLE, TRANSITIONAL CELL. | LESION INCIDENCE (NUMERIC) 1i 1 1 1 1H 1O H i TREATMENT (mg/kg/day) 25 100 250 IV VI VIII (10) (1) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 643321 (10) 643332 643340 643341 643359 643368 643370 643404 643408 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 386 'Centoatw Sws5?!*i ISoea no* contato TSC CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV >VI VIII RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED THROMBUS. (10) (1) (1) (ID 643354 643321 643392 643332 643361 643340 643362 643341 643374 643398 643406 643436 643477 643486 643359 643368 643370 643404 643408 643435 643446 643466 643463 Figur in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 387 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-G.eneration Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 388 Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM PHARYNX /LARYNX NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 389 Compan^ Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. FRACTURE/CALLUS, TOOTH. DEGENERATION, AMELOBLASTS. *5 TREATMENT (mg/kg/day) LESI03S INCIDIINCE (NtIMERIC) 0 25 100 250 II IV VI VIII (10) (10) (10) (11) 643354 643321 643323 643361 643324 643392 643362 643364 643462 643374 643380 643489 643398 643390 643406 643396 643436 643410 643463 643433 643477 643458 643486 643389 643340 643389 643322 643332 643366 643340 643367 643341 643409 643359 643461 643368 643472 643370 643404 643408 643435 643446 F ig u r e i n p a r e n th e s e s i s n u m b e r o f a n im a ls m ic r o s c o p ic a lly e x a m in e d f o r t h i s T he a b se n c e o f a n u m b er in d ic a te s th e le s io n s p e c if ie d w as n o t id e n tif ie d tis s u e 390 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII NOSE DEGENERATION, AMELOBLASTS. (10) (10) (10) (11) 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 391 SanWgetf. Does no! eonWn T S C A W H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED CARDIOMYOPATHY. TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV ' VI VIII (10) 643354 643361 643374 643406 643463 643477 643486 (1) 643362 643321 643398 643436 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 392 Company Sanitized. Does not contain trca c a t H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 393 Company Sanitized. Does not contain TSCA CBS H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED DEPLETION, LYMPHOID. , TREATMENT (mg/kg/day) l 1 11 H 1O H 1 LESION INCIDENCE (NUMERIC) 25 100 250 IV VI VIII (10) (1) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 643321 (10) 643332 643359 643370 643404 643408 643435 643446 643466 643340 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 394 Company Sanitized. Does not contain TSCA CB ]r ' ` H -2 4 5 16: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations IP DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED ATROPHY. | LESION INCIDENCE (NUMERIC) 1 O1 1 t 1 1 TREATMENT (mg/kg/day) H H 25 100 250 IV VI VIII (10) (1) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 643321 (11) 643332 643341 643359 643370 643404 643408 643435 643446 643466 643340 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 395 Company SanifHzed. Does noi contain TSC CB H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (l'l) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 396 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED 11 1M 1O H I | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 25 100 250 IV VI VIII (9) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 (9) 643332 643340 643341 643359 643368 643404 643408 643435 643446 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 397 Bompany Sanitized. B ees not contan TSC CBf u - i t j i u . ouucinomc oxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED HYPERPLASIA, GRANULOCYTIC. ATROPHY. TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 (1) 643321 (11) 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 398 olaonllntSCACffl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 399 ompany Sanitized, Does not contain TSCACBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. (10) (10) (10) (11) 643354 643321 643322 643340 643361 643364 643323 643368 643362 643390 643367 643370 643374 643396 643392 643398 643409 643406 643472 643436 643463 643477 643486 643359 643404 643408 643435 643446 643466 643324 643366 643332 643380 643461 643341 643389 643462 643359 643410 643489 643408 643433 643435 643458 643446 F ig u r e in p a r e n th e s e s i s n u m b e r o f a n im a ls m ic r o s c o p ic a lly e x a m in e d f o r t h i s T he a b se n c e o f a n u m b er in d ic a te s th e le s io n s p e c if ie d w as n o t id e n tif ie d tis s u e 400 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. PARATHYROID GLANDS NO ABNORMALITY DETECTED (10) (10) (10) (11) 643466 (6) (1) 643354 643321 643362 643374 643406 643436 643463 (7) 643332 643341 643368 643404 643408 643435 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 401 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV Vi Vili ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED (10) (1) fi41154 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 -- 402 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 y examined for this tissue The absence of a number indicates the lesion specified was not identified 403 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (1 1 ) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified npnir SunUteed. D m notcoM.fr, JSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 II 25 100 250 IV VI VIII ---- (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 405 Company Sanitized. Doe* not contain TSCA CBI i H-24516: Subchronic Toxicity ,. 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 ..... .. .--... TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) ------------------- ! LESION INCIDENCE (NUMERIC) LESIONS TREATMENT 0 25 100 250 (mg/.kg/day) II IV VI VIII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Fiqure"inTparentheses is number of animals microscopically examined for this tissue The9 absence of a number indicates the lesion specified was not identified 406 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (ID 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 407 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION)) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (ID 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 408 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII MUSCULAR AND SKELETAL SYSTEM MANDIBLE NO ABNORMALITY DETECTED DEGENERATION, AMELOBLASTS. (10) (9) (10) (8) 643354 643324 643322 643404 643361 643364 643323 643362 643380 643366 643374 643389 643367 643398 643390 643392 643406 643396 643409 643436 643410 643461 643463 643433 643462 643477 643458 643472 643486 643489 643332 643341 643359 643370 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -- 409 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 410 Do* not conia!" TSCA CBI C o m p l y Sanitized. H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 II 25 100 250 IV 'VI VIII REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED DILATATION, LUMEN. (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643340 643359 643368 643370 643404 643408 643446 643466 643332 643341 643435 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 411 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII REPRODUCTIVE SYSTEM MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 412 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 413 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS SPECIAL SENSES SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII EYE(S) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT. AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 643463 643477 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 643370 643446 643466 643340 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 414 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) M ICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS | LESION INCIDENCE (NUMERIC) 1----1 1 1 1H 1O I TREATMENT (mg/kg/day) H 50 250 1000 IV VI VIII DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED ATROPHY. (10) 641240 641245 641249 641283 641293 641384 641257 641290 641335 641344 (10) 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 415 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) '0 II 250 VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, MEDIAN CLEFT. (10) (10) 643415 643351 643405 643444 643330 643345 643336 643347 643377 643358 643387 643423 643405 643441 643426 643444 643448 643456 643453 643474 643481 643425 643441 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 416 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED ESOPHAGUS NO ABNORMALITY DETECTED STOMACH NO ABNORMALITY DETECTED DUODENUM NO ABNORMALITY DETECTED JEJUNUM NO ABNORMALITY DETECTED (1 ) 643336 (1 ) 643336 (1 ) 643336 (1 ) 643336 U) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 417 Company Sanitized. Does not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) 1 M1 1O HI LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) 250 VIII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED CECUM NO ABNORMALITY DETECTED COLON NO ABNORMALITY DETECTED RECTUM NO ABNORMALITY DETECTED SALIVARY GLANDS NO ABNORMALITY DETECTED (l) 643336 (1) 643336 (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 418 not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. NECROSIS, TUBULAR. MINERALIZATION. INFLAMMATION, ACUTE. HYPERPLASIA, TRANSITIONAL CELL. HYDRONEPHROSIS, BILATERAL. CYST. LESION INCIDI3NCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII (10) (10) 643387 643345 643405 643347 643448 643351 643474 643330 643358 643377 643423 643415 643441 643426 643444 643453 643456 643481 643336 643336 643336 643336 643425 643453 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 419 Company Sanitized. Does no! contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDEINCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII URINARY SYSTEM URINARY BLADDER INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA, SIMPLE, TRANSITIONAL CELL. HEMORRHAGE. (1) 643336 643336 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 420 Company SanHTzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED TRACHEA NO ABNORMALITY DETECTED PHARYNX/LARYNX NO ABNORMALITY DETECTED (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 421 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Female LESIONS TREATMENT (mg/kg/day) 0 II 250 VIII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED SQUAMOUS HYPERPLASIA, NASOLACRIMAL DUCT. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT. DEGENERATION, AMELOBLASTS. (10) (10) 643330 643351 643336 643423 643377 643474 643387 643405 643425 643426 643448 643453 643415 643456 643345 643347 643358 643441 643444 643456 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 422 "pany Sanitized. Does not contain TSCA CBl H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED AORTA NO ABNORMALITY DETECTED LESION INCIDI;NCE (NUMERIC) Female TREATMENT (mg/kg/day) -0 II 250 VIII (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 423 Company Sanitized Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED THYMUS ATROPHY. MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED BONE MARROW HYPERPLASIA, GRANULOCYTIC. LESION INCIDIJNCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII (l) 643336 (1) 643336 (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 424 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED HYPERPLASIA, DIFFUSE. THYROID GLAND NO ABNORMALITY DETECTED ALTERATION, COLLOID. (2) 643336 643415 (10) (10) 643336 643347 643387 643415 643448 643453 643330 643345 643377 643351 643405 643358 643425 643423 643426 643441 643444 643456 643474 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 425 S&nRtzed. Does no!contain TSCA CUT H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDEINCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED ADRENAL GLANDS NO ABNORMALITY DETECTED (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 426 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED SPINAL CORD . NO ABNORMALITY DETECTED SCIATIC NERVE NO ABNORMALITY DETECTED LESION INCIDI1NCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 427 Ccmnany Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) e ii 250 VIII MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED FEMUR/KNEE JOINT NO ABNORMALITY DETECTED STERNUM NO ABNORMALITY DETECTED MANDIBLE NO ABNORMALITY DETECTED (U 643336 (1) 643336 (1) 643336 (10) (10) 643330 643345 643336 643347 643377 643351 643387 643358 643405 643423 643415 643441 643425 643444 643426 643456 643448 643474 643453 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 428 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) 1 H1 1O Ml LESIONS LESION INCIDENCE (NUMERIC) Female TREATMENT (mg/kg/day) 250 VIII REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED UTERUS NO ABNORMALITY DETECTED MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED (U 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 429 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS CUTANEOUS SYSTEM LESION INCIDI3NCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII SKIN NO ABNORMALITY DETECTED (I) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 430 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS SPECIAL SENSES SYSTEM LESION INCIDI:NCE (NUMERIC) Female TREATMENT (mg/kg/day) 0 II 250 VIII EYE(S) WITH OPTIC NERVE NO ABNORMALITY DETECTED (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 431 Company Sanitized. Does not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS I LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL. DEGENERATION, AMELOBLASTS. (5) 643384 643402 643383 643465 643484 643383 643465 643484 (5) (5) 643373 643487 643382 643412 643360 643356 643381 643450 643360 643356 643381 643388 643450 643329 643356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 432 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED ALTERATION, COLLOID. | LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) II IV VI VIII ------ (5) (4) (5) (5) 643382 643383 643379 643360 643329 643384 643391 643373 643356 643402 643437 643381 643388 643465 643483 643412 643450 643484 643487 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 433 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 46 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Pj MALE RATS GROUP DOSE (mg/kg/day) N TEST DAY 78 85 92 99 106 1-0 III-O V-0 VII-0 0 25 100 250 20 20 20 19 MEAN BODY WEIGHT (grams) 555.6(62.6)3 569.5(63.3) 583.4(64.4) 595.7(63.2) 607.6(64.7) 543.9 (52.9) 555.3(54.7) 568.8(56.5) 582.2(58.0) 590.5(62.5) 547.5 (36.3) 559.3 (39.0) 569.5(40.7) 579.1(45.6) 574.2 (52.3) 495.0 (48.1)* 516.1 (47.0)* 531.1(51.7)* 539.0 (59.8)* 547.2 (65.3)* GROUP 1-0 III-O V-0 VII-0 DOSE 0 25 100 250 (mg/kg/day) N 20 20 20 19 TEST DAYS MEAN BODY WEIGHT GAIN (grams) 78-85 85-92 92-99 99-106 13.9 (6.1)a 13.9(6.7) 12.3 (5.5) 12.0(5.0) 11.4(8.5) 13.5(5.8) 13.4(6.4) 8.4(7.5) 11.7(7.3) 10.2(8.0) 9.7(10.3) -5.0(21.7)* 21.2(11.3) 14.9(8.4) 7.9(15.2) 8.3(8.9)* 78-106 52.0(7.1) 46.7(16.5) 26.6(30.1) a Standard deviation is reported in parentheses. 52.2(32.7) * Statistically significant difference from control by Jonckheere-Terpstra test (p < 0.05). 434 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 47 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N GESTATION DAY 0 7 14 21 II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 MEAN BODY WEIGHT (grams) 305.7 (31.8)a 333.9(33.3) 367.0 (35.1) 453.2 (39.0)c 315.2 (23.3) 344.4(28.1) 370.0(22.4) 454.9(55.4)d 302.1(18.5) 333.4(17.1) 366.0 (19.2) 432.7 (40.0)d 300.3(22.0) 329.2(28.6) 367.2(22.0)^ 444.5(35.5)d GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 GESTATION DAYS 0-7 7-14 14-21 MEAN BODY WEIGHT GAIN (grams) 28.2 (6.0)a 33.1 (5.4) 86.5 (16.1)c 29.2 (8.8) 25.5(14.2) 82.4 (44. 5) d 31.3(6.9) 32.5(5.0) 71.9 (28.3)d 28.9(23.0) 32.9(6.1)^ 82.0 (33.5)** 0-21 146.1(19.3)C 135.8 (45.7)d 135.1(29.7)d a Standard deviation is reported in parentheses. b N = 13. c N = 10. d N = 11. 146.2(34.6)d There were no statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). Company Sanitized. Does noi contain TSCA c bi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 48 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N LACTATION naY 0 7 14 21 II-O 0 13 IV-0 25 17 VI-0 100 14 MEAN BODY WEIGHT (grams) 345.5 (36.2)a 346.9(31.0) 360.6(33.4) 351.2 (30.6) 351.6(29.8) 351.3(30.7) 380.9(18.9) 365.9(18.4) 337.2(32.9) 350.0(21.0) 371.4(18.1) 360.4(14.8) VIII-0 250 13 341.7(21.2) 349.3(25.3) 362.7(28.9) 341.1 (41.2) GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 17 VI-0 100 14 VIII-0 250 13 LACTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 1.4 (22.1 )a 13.7(20.7) -9.4(10.9) -0.3(22.6) 29.6(19.7) -15.0(14.2) 12.8(27.7) 21.4(11.2) -11.1(13.1) 7.6(17.0) 13.3(29.9) -21.5(43.5) 0-21 5.7(20.8) 14.2(21.3)_____ 23.1 (28.5) a Standard deviation is reported in parentheses. -0.6(38.4) * Statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). 436 Company Sanitized. Does not contain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 49 MEAN DAILY FOOD CONSUMPTION AND MEAN FOOD EFFICIENCY OF Pi FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 GESTATION DAYS MEAN DAILY FOOD CONSUMPTION (grams) 0-7 7-14 14-21 24.8(3.9)a 29.5(3.7) 26.1(5.7) 25.2(2.9) 26.6 (3.2) 27.2(3.4) 25.8 (2.1) 28.4(1.9) 27.0(3.1) 26.8(4.5) 29.2(3.1) 26.5(4.5)* 0-21 26.8(3.6) 26.4(2.7) 27.1(1.8) a Standard deviation is reported in parentheses. b N = 13. 27.6 (2.5)* There were no statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 V I -0 100 15 VIII-0 250 14 GESTATION DAYS 0-7 7-14 14-21 MEAN FOOD EFFICIENCY (grams weiqht qain/qrams food consumed) 0.167 (.046)a 0.162 (.028) 0.553 (.312) 0.163(.039) 0.141 (.072) 0.365 (.238) 0.172 (.031) 0.163 (.022) 0.395 (.178) 0.134(.172) 0.165(.032) 0.440(.206)* 0-21 0.268 (.053) 0.224 (.088) 0.241 (.057) a Standard deviation is reported in parentheses. b N = 13. 0.254(.056)* There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). 437 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 50 SUMMARY OF CLINICAL OBSERVATIONS IN Pi RATS P i MALE RATS GROUP DOSE (mg/kg/day) N Number of Rats with Observation 1-0 III-O V-0 VII-0 0 25 100 250 20 20 20 19 OBSERVATIONS Alopecia Colored Discharge Eye(s) Colored Discharge Nose Teeth Clipped Teeth Crooked 102 00 0 000 00 0 000 Total No. of Rats with Masses 000 Statistically significant trend by Cochran-Armitage test; p < 0.05. 1 2 1 5* 1 0 438 SsrtNfeed, Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 50 (CONTINUED) SUMMARY OF CLINICAL OBSERVATIONS IN Pi RATS P1 FEMALE RATS DURING GESTATION OBSERVATIONS Alopecia Diarrhea Sore Stained Abdomen Stained Face Stained Perineum Teeth Clipped Weak Wet Perineum Wet Underbody GROUP DOSE (mg/kg/day) N Number of Rats with Observation II-O IV-0 VI-0 VIII-0 0 25 100 250 18 19 19 17 1122 00 01 10 00 00 10 00 01 00 11 00 01 00 01 00 01 00 01 Total No. of Rats with Masses 00 00 Note: This table includes clinical observations from pregnant animals only. P i FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N OBSERVATIONS Abnormal Gait or Mobility Alopecia Colored Discharge Nose Discharge Vaginal Opening Hunched Over Teeth Clipped Number of Rats with Observation II-O IV-0 VI-0 VIII-0 0 25 100 250 13 17 14 14 00 1 0 13 4 1 00 1 0 01 1 0 00 10 00 01 Total No. of Rats with Masses 00 00 There were no statistically significant trends by Cochran-Armitage test ; p < 0.05. 439 Company SanHIzed. Does not contain TRCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 51 MEAN ESTROUS CYCLE PARAMETERS AND PRECOITAL INTERVAL IN Pi FEMALE RATS Percent Percent Percent of Days of Days of Days Mean Cycle Dose in in in Length Group (mq/kg/day) N Estrus Diestrus Proestrus (days) Mean Precoital Interval (days) II-O 0 20 29 60 11 4.7(1.54)3/* 3.8(2.46)c IV-0 25 19 22 65 13 4.5(0.81) 3.3(2.86) VI-0 100 20 25 63 12 4.6(0.73)* 2.5(1.31)* VIII-0 250 18 20 69 12 4.7(1.35) a Standard deviation is presented in parentheses. b N=19 c N=18 d N=17 3.6(2.21)d There were no significant trends (Jonckheere1s test); p < 0.05. 440 r pa", SanlUzed. Doe* M com,, t s c a ^ H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 52 SUMMARY OF SPERM PARAMETERS IN Pi MALE RATS Group I-0 Dose (mg/kg/day)_____ 0 III-O 25 V-0 100 VII-0 250 MOTILITY Percent Motile S.D. 93.3 3.6(10)a 92.2 5.8(10) 93.3 4.0(10) 90.3 6 .1 (10 ) MORPHOLOGY Percent Normal S.D. 98.8 0.8(10) 99.0 1 .1 (10) 99.2 0.7(10) 98.9 1 . 1 (10) EPIDIDYMAL SPERM (Millions) Per Cauda 298.7 S.D. 32.3(10) Per gram Cauda S.D. 1030.9 171.6 (10) TESTICULAR SPERMATIDS (Millions) Per Testis 130.1 S.D. 17.1(10) Per gram Testis S.D. 84.5 12.3(10) 279.8 39.8(10) 998.3 144.3(10) 121.8 13.6(10) 84.5 12.0(10) 278.0 44.9 (10) 949.8 178.4(10) 159.9* 10.3(10) 1 01.1* 9.1(10) 299.2 66.9 (10) 945.7 150.5(10) 146.5* 17.3 (10) 93.2* 9.5 (10) a Number in group is in parentheses. * statistically significant trend by Jonckheere-Terpstra test; p <0.05. 441 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 53 SUMMARY OF REPRODUCTIVE INDICES: Pi GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 25 MATING INDEX (%) (# copulated/cohoused) 90.0 100.0 (18/20) (20/20) FERTILITY INDEX (%) (# delivered/copulated) 72.2 85.0 (13/18) (17/20) GESTATION LENGTH (days) Number of Implantation Sites per pregnant female 22.3 14.0 (4.53)a 22.2 13.4 (4.58) VI-0 100 95.0 (19/20) 73.7 (14/19) 22.4 13.9 (2.95) VIII-0 250 94.7 (18/19) 77.8 (14/18) 22.4 14.1 (2.93) Implantation Efficiency (%)-b 96.6 (3.33) 90.5 83.4* 84.5* (13.47) (16.16) (19.10) a Standard deviation is reported in parentheses. b Number of pups born/number of implantation sites X 100. There were no statistically significant trends in mating or fertility indices by Cochran-Armitage test; p < 0.05. There was no statistically significant difference from control in gestation length by One-Way Analysis of Variance; p < 0.05. * Statistically significant trend by Jonckheere's test; p < 0.05. 442 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 54 MEAN PUP NUMBERS AND SURVIVAL: Fi GENERATION MATERNAL GROUP II-0 DOSE (mg/kg/day) 0 ^ N 13 IV-0 25 17 VI-0 100 14 VIII-0 250 13 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF PUPS/LITTER 14.7 14.6 14.6 8.0 8.0 8.0 8.0 13.4 13.2 12.9 7.6 7.6 7.6 7.6 12.4 11.3 10.0* 6.3 6.3 6.3 6.3 12.5* 12.1* 11.8* 7.5 7.4 7.4 7.4 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF MALE PUPS/LITTER 8.7 7.2 5.9 7.1 8.6 7.1 5.4 6.7 8.6 7.1 4.7 6.5 4.2 3.6 3.3 3.6 4.2 3.6 3.3 3.9 4.2 3.6 3.3 3.6 4.2 3.6 3.3 3.6 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF FEMALE PUPS/LITTER 6.0 6.1 6.0 6.1 6.0 5.8 3.8 4.0 3.8 4.0 3.8 4.0 3.8 4.0 Sex Ratio (males) Gestation Indexa Mean % Born Alive 0-4 Day Viability Lactation Index-t* Litter Survivalc SURVIVAL (%) 0.59 100.0 99.5 100.0 100.0 100.0 0.50 100.0 99.2 97.6 100.0 100.0 a Percent litters delivered having at least one live pup. b Mean percent survival from day 4 postculling to day 21. c Percent litters born with at least one pup alive on day 21. 6.5 5.9 5.3 3.0 3.0 3.0 3.0 0.50 92.9 88.4 90.6 100.0 92.3 5.5 5.4 5.3 3.8 3.8 3.8 3.8 0.56 100.0 92.4 97.3 92.3 92.3 * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. Statistics were performed on combined pups per litter only. Male and female data are presented for information only. 443 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 55 MEAN PUP WEIGHTS: Fi GENERATION MATERNAL GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 17 V I -0 100 13 VIII-0 250 13 MEAN PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.9 (0.7)3 11.3 (1.5) 11.4 (1.6) 18.3 (1.9) 37.9 (3.4) 60.9 (6.9) 6.7 (0.6) 11.4 (1.6) 11.4 (1.7) 18.0 (2.2) 37.0 (3.0) 60.3 (5.5) 6.8 (0.7)* 11.9 (1.8) 11.9 (1.9) 18.3 (2.4) 36.1 (3.2) 58.3 (4.3) 6.4 (0.6) 10.1 (1.7) * 10.1 (1.7)* 15.5 (2.1) * 29.5 (3.4) * 45.4 (7.7)* MEAN MALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 7.0 (0.7) 11.6 (1.5) 11.7 (1.5) 18.8 (2.0) 38.7 (3.6) 62.5 (7.4) 6.9 (0.7) c 11.5 (1.7) 11.5 (1.7) 18.2 (2.3) 37.7 (3.2) 61.7 (6.2) 6.9 (0.8)* 12.3 (1.9) 12.3 (2.0) 18.9 (2.3) 37.1 (3.1) 60.2 (4.3) 6.7 (0.5) 10.7 (0.8) 10.8 (0.7) 15.7 (2.3) 29.6 (3.8) 45.7 (7.7) MEAN FEMALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.6 (0.7) 10.9 (1.5) 11.0 (1.6) 17.6 (1.9) 37.0 (3.2) 59.1 (6.3) 6.5 (0.6) c 11.1 (1.8) 11.2 (1.8) 17.6 (2.2) 36.5 (3.0) 59.0 (5.5) a Standard deviation is reported in parentheses. b N = 12. c N = 14. 6.5 (0.7)* 11.5 (1.7) 11.4 (1.9) 17.5 (2.7) 35.0 (3.6) 56.0 (4.7) 6.2 (0.6) 9.8 (1.7) 9.9 (1.8) 15.3 (2.0) 29.3 (3.1) 45.0 (8.0) * Statistically significant trends by linea'r contrast of least square means; p < 0.05. Note: Statistical analyses were conducted on the combined pup weights. Male and female data are presented for information only. 444 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 56 SUMMARY OF PUP CLINICAL OBSERVATIONS: Fi GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 25 VI-0 100 VIII-0 250 OBSERVATIONS Discharge Nose Weak 0 0 0 3 ( 1)3 0 0 0 2 ( 1) TOTAL NUMBER OF OBSERVATIONS NUMBER OF LITTERS AFFECTED TOTAL NUMBER OF LITTERS ___ 00 0 000 13 17 13 a Numbers outside the parentheses are the number of pups affected; the numbers in parentheses are the number of litters affected. 5 1 13 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. 445 Company Sanitized. Does not conta'n TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 57 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF F, MALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 1-1 0 13 63.3 (7.5)* 108.7 (12.8) 172.2 (18.0) 236.3 (21.9) 294.7(31.0) 333.4 (33.5) III-l 25 16 V-l 100 12 MEAN BODY WEIGHT (grams) 62.5(7.0) 103.9(10.3) 163.9(15.3) 224.0(16.9) 278.7(23.6) 331.8 (31.3)c 58.6(5.6) 100.5(8.9) 161.3(13.0) 223.0(11.5) 279.2 (20.4) 310.5(35.5) VII-1 250 12 47.0 (5.3)* 88.0(6.8)* 144.5 (11.6)* 206.0(11.4)* 264.0(28.4)* 310.2(40.2)* GROUP DOSE (mg/kg/day) N 1-1 0 13 III-l 25 16 V-l 100 12 DAYS ON TEST3 MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 15-22 22-29 29-36 45.3 (6.4)* 63.5 (6.8) 64.1(7.0) 58.4(13.8) 38.7(31.8) 41.5(5.0) 60.0(6.0) 60.1(5.5) 54.7(16.5) 54.6 (20.1)c 41.9 (4.4) 60.8(5.2) 61.7 (5.0) 56.3 (15.6) 31.2(19.3) 1-36 270.1(30.2) 269.7 (28.9)C 251.9(33.3) a Day of Weaning = Test Day 1. Jb Standard deviation is reported in parentheses, c N = 15. VII-1 250 12 41.0(7.4) 56.5(6.7)* 61.5(5.7) 58.0(22.5) 46.1(25.5) 263.2(42.3) * Statistically significant trend by Jonckheere-Terpstra test p < 0.05. 446 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 58 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Fi FEMALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 II-l 0 13 IV-1 25 17 V I -1 100 12 VIII-1 250 12 57.3 (6.3 )-b 94.0(7.8) 135.8(9.6) 167.5(13.4) 190.0(17.5) 206.4(16.3) MEAN BODY WEIGHT (grams) 58.6 (6.3) 94.8(8.3) 139.6(13.9) 173.7(21.6) 195.6 (24.2) 218.8 (30.7) c 56.7(4.9) 90.4(7.0) 133.6(8.3) 167.5 (10.8) 191.4 (15.8) 2 1 2 .6( (17.7) 44.7(8.1)* 80.0(9.6)* 124.8(9.1)* 161.7 (9.8) 187.7(13.4) 206.3(13.9) GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 V I -1 100 12 DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 1-36 36.8 (4,2)b 41.8(6.4) 31.7 (8.4) 22.5 (6.1) 16.4 (7.0) 149.1(17.7) MEAN BODY WEIGHT GAIN (grams) 36.2(3.8) 44.7(7.1) 34.2(9.1) 21.9(7.7) 22.6 (9.1)c 160.3 (26.7)c 33.7(5.4) 43.2(5.7) 33.9(5.4) 23.9(6.9) 21.1 (4.2) 155.9(16.3) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses, c N = 16. VIII-1 250 12 35.2 (6.4) 44.8(4.1) 36.9(5.6) 26.0(8.3) 18.6(13.1) 161.5(18.7) * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. 447 Contnsnv S<*nifre d. Does noi cenfsin TSCA CBF H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 59 SUMMARY OF CLINICAL OBSERVATIONS IN Fi RATS Fi MALE RATS GROUP (mg/kg/day) N Number of Rats with Given Observation 1-1 III-l V-l VII-1 0 25 100 250 13 16 12 12 OBSERVATIONS There were no abnormal clinical observations observed in the Fx Male Rats. Total No. of Rats with Masses 0 0 0________ 0 Fx FEMALE RATS Number of Rats with Given Observation GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 VI-1 100 12 VIII-1 250 12 OBSERVATIONS Alopecia Total No. of Rats with Masses 010 0 000 0 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. 448 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 60 SUMMARY OF DEVELOPMENTAL LANDMARKS IN Fi RATS PREPUTIAL SEPARATION - Fi MALE RATS GROUP 1-1 III-l V-l VII-1 DOSE (mg/kg/day) 0 25 100 250 N 13 16 12 12 AGE (Days)a 39.9 (2.22) 41.5 (2.90) 43.2 (3.16) 42.7 (2.10) VAGINAL OPENING - Fi FEMALE RATS GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 VI-1 100 12 VIII-1 250 12 AGE (Days)a 32.1 (2.43) 32.2 (2.28) Data summarized as : Mean Standard Deviation 32.1 (1.93) 32.5 (2.58) a Age was calculated as follows using data presented in Appendix LL: Test day + 20 days = Age (days). There were no statistically significant trends by linear contrast of least square means (covariate:body weight). 449 Company Sanitized. Does not contain TSCA CBI QmnnMi VnnlHaoiV Ha m I Wlf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 61 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - P, ADULTS GROUP DOSE (MG/KG/DAY) THYROID 1-0 0 0.021 0.003(12 ) III-O 25 0.020 0.004(17 ) V-0 100 0.022 0.005(14 ) VII-0 250 0.025 0.007(14 ) FINAL BODY 604.692 594.429 557.193 541.471# 62.781(12 ) 57.077(17 ) 61.905(14 ) 65.972(14 ) THYROID/FINAL BODY * 100 0.004 0.000 (12 0.003 0.001(17 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra) # Statistically significant difference at p < 0.05. 0.004 0.001(14 ) 0.005# 0.001(14 ) DuPont-5368 450 Company Sanitized. Does not contain TSCA CBf TABLE 62 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Pi ADULTS GROUP DOSE (MG/KG/DAY) THYROID FINAL BODY II-O 0 0.019 0.004(11 ) 351.700 33.050(11 ) IV-0 25 0.021 0.004(17 ) 365.888 18.416(17 ) V I -0 100 0.020 0.004(12 ) 359.208 15.076(12 ) VIII-0 250 0.022 0.005(12 ) 338.008 41.391(12 ) THYROID/FINAL BODY * 100 0.006 0 . 001(11 ) 0.006 0.001(17 ) Data summarized as: Mean. Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). No statistically significant difference at p < 0.05. 0.006 0 . 001(12 ) 0.006 0 .002(12 ) Company Sanitized. Does not contain TSCACBI TABLE 63 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) GROUP DOSE (MG/KG/DAY) BRAIN 1-1 0 1.996 0.093(13 ) III-l 25 1.949 0.069(16 ) EPIDIDYMIDES 0.760 0.067(13 ) 0.738 0.092(16 ) TESTES 3.300 0.228(13 ) 3.154 0.177(16 ) SEMINAL VESICLES 1.200 0.205(13 ) 1.074 0.202(16 ) PROSTATE 0.460 0.126(13 ) 0.409 0.083(16 ) THYROID 0.019 0.004(13 ) 0.017 0.003 (16 ) KIDNEYS 3.283 0.291(13 ) 3.154 0.264(16 ) LIVER 17.488 1.869(13 ) 16.938 1.829(16 ) FINAL BODY 384.823 372.338 31.437(13 ) 25.695(16 ) V-l 100 1.966 0.106(12 ) 0.739 0.048(12 ) 3.220 0.254(12 ) 1.085 0.257(12 ) 0.368 0.087(12 ) 0.015 0.004(12 ) 3.199 0.293(12 ) 17.100 2.729(12 ) 376.133 26.968(12 ) VII-1 250 1.978 0.072(12 ) 0.686# 0.065(12 ) 3.039# 0.439(12 ) 1.084 0.187(12 ) 0.406 0.116(12 ) 0.018 0.004(12 ) 3.253 0.270(12 ) 16.037# 1.240(12 ) 360.375# 36.754(12 ) 452 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity DuPont-5368 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________ __________________________ ________ TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DOSE (MG/KG/DAY) 1-1 III-l 0 25 BRAIN/FINAL BODY * 100 0.521 0.034(13 ) 0.525 0.028(16 ) EPIDIDYMIDES/FINAL BODY * 100 0.198 0.014(13 ) 0.198 0.019(16 ) TESTES/FINAL BODY * 100 0.860 0.044(13 ) 0.848 0.034(16 ) SEMINAL VESICLES/FINAL BODY * 100 0.311 0.037(13 ) 0.288 0.045(16 ) PROSTATE/FINAL BODY * 100 0.119 0.029(13 ) 0.110 0.020(16 ) THYROID/FINAL BODY * 100 0.005 0.001(13 ) 0.005 0.001(16 ) KIDNEYS/FINAL BODY * 100 0.854 0.051(13 ) 0.848 0.061(16 ) V-l 100 0.525 0.049(12 ) 0.197 0.014(12 ) 0.860 0.091(12 ) 0.287 0.055(12 ) 0.098 0.022(12 ) 0.004 0.001(12 ) 0.851 0.059(12 ) VII-1 250 0.553 0.048(12 ) 0.191 0.015(12 ) 0.843 0.077(12 ) 0.303 0.057(12 ) 0.112 0.024(12 ) 0.005 0.001(12 ) 0.906 0.068(12 ) Company Sanitized. Does not contain TSCA CBI TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - F! ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DOSE (MG/KG/DAY) III-l 25 LIVER/FINAL BODY * 100 4.543 n 290(13 4.546 0.327(16 ) V -l 100 4.525 0.479 (12 V II-1 250 4.468 0.329(12 ) M EA N R E L A T IV E O R G A N W E IG H T S ( o r g a n t o b r a i n w e ig h t r a t i o j GROUP D O S E (M G /K G /D A Y ) LIVER/BRAIN*100 1-1 0 875.891 82.315(13 ) H I-1 25 868.962 90.420(16 ) V -l 100 873.051 149.566(12 ) V II-1 250 811.923 70.037(12 ) KIDNEYS/BRAIN*100 164.486 12.752(13 ) 161.723 11.469(16 ) 163.152 17.372(12 ) 164.691 14.841(12 ) PROSTATE/BRAIN *10 0 23.017 5.990(13 ) 20.936 4.034(16 ) 18.712 4.085(12 ) 20.513 5.677(12 ) SEMINAL VESICLES/BRAIN*100 59.952 8.655(13 ) 55.060 10.071(16 ) 55.069 12.064(12 ) 54.769 9.181(12 ) TESTES/BRAIN*100 165.435 9.973(13 ) 161.842 8.064(16 ) 164.109 14.137(12 ) 153.809 22.378(12 ) Company Sanitized. Does not contain TSCA CB1 TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - F, ADULTS EPIDIDYMIDES/BRAIN*100 38.113 3.175(13 ) 37.831 4.196(16 ) THYROID/BRAIN*100 0.953 0.215(13 ) 0.861 0.163(16 ) Data summarized as : Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 37.650 2.899(12 ) 0.775 0.192(12 ) 34.712# 3.437(12 ) 0.933 0 .221(12 ) Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity , 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________ . , TABLE 64 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (qrams) GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 BRAIN 1.829 0.061(13 ) 1.849 0.082(17 ) UTERUS 0.429 0.087(13 ) 0.470 0.140(17 ) THYROID 0.016 0.003(13 ) 0.015 0.003(17 ) KIDNEYS 1.886 0.154(13 ) 2.038 0.249(17 ) LIVER 9.063 1.385(13 ) 9.589 1.727(17 ) FINAL BODY 218.431 226.071 19.969(13 ) 29.359(17 ) V I -1 100 1.799 0.091(12 ) 0.450 0.115(12 ) 0.016 0.003(12 ) 2.051 0.247(12 ) 9.593 1.329(12 ) 223.750 19.600(12 ) VIII-1 250 1.810 0.057(12 ) 0.583 0.604(12 ) 0.013 0.002(12 ) 2.039 0.211(12 ) 9.986 0.958(12 ) 222.475 15.014(12 ) DuPont-5368 Company Sanitized. Does not confa'n W i <*bj TABLE 64 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weiqht) GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 BRAIN/FINAL BODY * 100 0.844 0.083(13 ) 0.829 0.096(17 ) UTERUS/FINAL BODY * 100 0.198 0.040(13 ) 0.210 0.065(17 ) THYROID/FINAL BODY * 100 0.007 0.001(13 ) 0.007 0.002(17 ) KIDNEYS/FINAL BODY * 100 0.867 0.079(13 ) 0.904 0.052(17 ) LIVER/FINAL BODY * 100 4.136 0.403(13 ) 4.227 0.406(17 ) V I -1 100 0.810 0.085(12 ) 0.203 0.057(12 ) 0.007 0.002(12 ) 0.921 0.119(12 ) 4.281 0.361(12 ) VIII-1 250 0.817 0.061(12 ) 0.258 0.251(12 ) 0.006 0.001(12 ) 0.917 0.079(12 ) 4.492# 0.372(12 ) Misaw PRT.ATTVE ORGAN WEIGHTS (organ to brain weight ratio) GROUP DOSE (MG/KG/DAY) LIVER/BRAIN*100 II-l 0 496.052 77.065(13 ) IV-1 25 517.938 86.356(17 ) V I -1 100 534.812 80.407(12 ) VIII-1 250 552.297# 55.783(12 ) Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 ____________________________ _______________ ___________________________ TABLE 64 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS M EA N R E L A T IV E O R G A N W E IG H T S ( o r g a n t o b r a i n w e ig h t r a t i o | GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 KIDNEYS/BRAIN*100 103.192 8.825(13 ) 110.086 11.594(17 ) V I -1 100 114.319# 15.371(12 ) VIII-1 250 112.713# 12.284(12 ) THYROID/BRAIN*100 0.867 0.164(13 ) 0.804 0.187(17 ) 0.898 0.189(12 ) 0.718 0.128(12 ) UTERUS/BRAIN*100 23.473 4.657 (13 ) 25.407 7.477(17 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods : Trend test (Jonckheere-Terpstra) . # Statistically significant difference at p < 0.05. 24.873 5.632(12 ) 32.194 33.171(12 ) Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 65 SITE/LESIO N : INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Pi ADULTS GROUP DESIGNATION: DOSE (M G/KG/DAY): NUMBER IN GROUP: 1-0 0 20 :==== II II II II II II II 11 II II II II II II III-O 25 20 V-0 100 20 EPIDIDYMIDES LARGE 0* a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESIO N . 0 0 II II II 11 II II II II II II II II II II II II II II II II II II II DuPont-5368 VII-0 250 19 1 459 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ------ ----------------- SITE/LESION: TABLE 66 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Pi ADULTS GROUP DESIGNATION DOSE (MG/KG/DAY): NUMBER IN GROUP: II-O 0 20 IV-0 25 20 V I -0 100 20 LIVER DISCOLORATION STOMACH DISTENDED WITH GAS SMALL INTESTINE DISTENDED WITH GAS KIDNEYS DILATATION UTERUS HEMORRHAGE OBSTRUCTION ia 0 n0 n0 u 00 ,,0 Q0 0 0 0 0 0 0 DuPont-5368 --------------------------------- VIII-0 250 19 0 1 1 1 1 1 Company Sanitized. Does not contain TSCA CBI 'flip H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 S IT E /L E S IO N : TABLE 67 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi PUPS DAM G R O U P D E S IG N A T IO N : D O SE (M G /K G /D A Y ): N UM BER P U P S /L IT T E R S : II-O o 1/1 IV-0 25 2/2 V I -0 100 7/3 S_ ---- VIII -0 250 5/3 II II II II II II II II II II II II II II II II II II II It II II II II II II II II u II II II STOM ACH NO M IL K SPO T 0 ( 0) 2 ( 2) 4 ( 1) 3 ( 3) P E R IT O N E A L C A V IT Y C A N N IB A L IZ E D 0 ( 0) 0 ( 0) 0 ( 0) 1 ( 1) LUNGS NOT EXPANDED 0 ( 0) 2 ( 2) 4 ( 1) 3 ( 3) TOTAL TO TA L 02 L IT T E R S A FFE C T E D 02 rP UU Pr oS AM F tFt Ei C Tl uE Du ______________________ _________________________________________________________ _______________________________________ _______________________________ ; 1 4 : 3 4 For ach group : The count of S c r S p B P S S n t V ? t o T S c r e r i n . t i o n . For ,, o n .ite/taaion, ~ outai* 461 Company Sanitized. Does not contain TSCA CBI SITE/LESION: TABLE 68 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 VI-0 100 8/3 vm -o 250 4/2 STOMACH NO MILK SPOT 0 ( 0) 0 ( 0) 5 ( 1) 1 ( 1) LUNGS NOT EXPANDED 0 ( 0) 0 ( 0) 5( TOTAL TTOTi AAlLl LITTERS AFFECTED PF UUPP Sb AA Fr gFcE. CL Ti DEDu -------------------------_ ------------------------------------- _ 00 00 ------------------- --------------------------------------------------------------------------------------- - 1 5 For each group: The count of 1) . 1 ( 1) 1 1 .. examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBf L SITE/LESION: TABLE 69 INCIDENCES OF GROSS OBSERVATIONS IN RATS - Fi UNSEXABLE PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 V I -0 100 0/0 VIII-0 250 13/1 WHOLE BODY AUTOLYSIS 0 ( 0) 0 ( 0) 0( 000 TOTAL TOTAL LITTERS AFFECTED PUPSB AFFECTED_________ _____________________ _________0________ 0 _____________ ; 0 _ 0) , 10 ( 1 10 , For each group, The count of in S c r p S p PS 5 e r w I n r p . " 0" S?cil examination. For each elte/teelon, here Company SanHteed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION TABLE 70 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi WEANLINGS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 42 III-l 25 45 V-l 100 34 KIDNEYS LARGE SMALL_____ 03 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 1 1 0 0 1I1I II II II II II II II 1I1I II II II I1I1 I1I1 II II II II II II II II II II DuPont-5368 vu-: 250 35 0 0 H-24516: Subchronic Toxicity . DuPont-5368 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________ ___________ ____________________ _________________________ SITE/LESION: TABLE 71 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - F, WEANLINGS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-1 0 _36__ VI-1 100 30 VIII-1 250 37 THERE WERE NO GROSS OBSERVATIONS Company Sanitized. D oes no! contain TSCA CBf SITE/LESION: TABLE 72 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi ADULTS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 13 III-l 25 16 V-l 100 12 36 VII-1 250 12 0 II II II II tl II II II II II II u II II II II II II II II H II II II II 11 II II II Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 73 SITE/LESION: INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi ADULTS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-l 0 13 := = = = = IV-1 25 17 V I -1 100 12 II 11 II II II II II II II II II II II II II II II II II II II II II II KIDNEYS DILATATION 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 2 II II II II II II II II II II II II II DuPont-5368 VIII-1 250 12 0 467 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 74 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN M ALE REPRODUCTION RATS - P! ADULTS GROUP DESIGNATION: LESION GRADES DOSE (MG/KG/DAY): TISSUE/LESION (P,1,2,3,4) NUMBER IN GROUP: 1-0 0 20 III-O 25 20 V-0 100 20 VII-0 250 19 TESTIS3 TESTES EPIDIDYMIS3 EPIDIDYMIDES PROSTATE INFLAMMATION, SUBACUTE/CHRONIC SEMINAL VESICLES COAGULATING GLAND OTHER ___ 41 32 41 32 73 1 3 3 3 3 6 1 (-,1, 6 6 0 2 3 2 3 5 1 (-,1, 5 5 0 THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. Tttqton GRADES' P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. LESION GRADES'CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRAD GRADES TM h^ pLE: , x 2 , MEANS N0 LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS) , 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESI WERE GRADED "SEVERE". One of the pair available for microscopic examination, Sperm parameter evaluation was performed on the second of the pair. 468 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 TABLE 75 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE REPRODUCTION RATS - Pi ADULTS LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: Il-O 0 20 IV-0 25 20 VI-0 100 20 VIII-0 250 19 OVARIES UTERUS DILATATION, GLAND/LUMEN VAGINA OTHER LIVER: NECROSIS, FOCAL SKIN: NO ABNORMALITIES DETECTED 8 8 - 8 2 1 (-,1,1 (1,-,- 3 3 1 (-,1, 3 0 8 8 3 (-,1, 2,-,-) 8 0 5 5 5 0 o THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. SisEF' i l e s io n TM ' grIS ed A WERE GRADED "SEVERE". 2n i m a l - , l e s io n s w ere g ra d ed - m il d - , n o l e s io n s w ere g r a d ed "m o d e r a t e - a n d n o l e s io n s 469 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURES 470 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURES EXPLANATORY NOTES Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 90 Recovery period begins for rats designated for one-month and 3-month recovery periods. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 92 Last day o f test substance administration for female rats designated for the 90-day exposure period. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day of non-fasted body weight data collection for rats designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day of non-fasted body weight data collection for rats designated for the 3-month recovery period. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. 471 SanHtized, 0@s isfcontain JBCA <SBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 1 MEAN BODY WEIGHTS OF MALE RATS DuPont-5368 * On test day 74, male and female rats designated for reproduction evaluations were co-housed. On test day 77, all rats in the 250 mg/kg/day dose group were placed on ground chow. 472 Company SanMzed. Docs not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 2 MEAN BODY WEIGHTS OF FEMALE RATS '9 ? DuPont-5368 * On test day 74, male and female rats designated for reproduction evaluations were co-housed. On test day 77, all rats in the 250 mg/kg/day dose group were placed on ground chow. 473 C om pany SanWzed. Does contain T S C A C B f H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURE 3 MEAN FORELIMB GRIP STRENGTH FOR MALE RATS Forelimb Grip Strength (kg) 2.00 -I 1.80 1.60 1.40 1.20 1.00 0.80 0.60 0.40 0.20 0.00 - Baseline 0 mg/kg/day _ _ I I 25 mg/kg/day 100 mgkgday B 2 5 0 mg/kg/day W eek 13 Assessment Period Recovery 474 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 4 MEAN FORELIMB GRIP STRENGTH FOR FEMALE RATS DuPont-5368 1.60 1.40 1.20 Forelimb Grip Strength (kg) 1.00 D 0 mg/kg/day 0.80 0.60 I0.40 H 25 mg/kg/day ^ 100mgkgday 0.20 0.00 Baseline W eek 13 Assessment Period Con<Panjr Sanitized. Does no contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 5 MEAN HINDLIMB GRIP STRENGTH FOR MALE RATS DuPont-5368 Hindlimb Grip Strength (kg) 1= B 2 5 mg/kg/day 1 100 m gkgday W eek 13 Assessment Period 476 I Recovery contain TSCACBF H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 6 MEAN HINDLIMB GRIP STRENGTH FOR FEMALE RATS DuPont-5368 Hindlimb Grip Strength (kg) 0.90 0.80 0.70 0.60 0.50 0.40 0.30 0.20 0.10 0.00 Baseline 0 mg/kg/day H 25 mg/kg/day H 100 m gkgday M250 mg/kg/day W eek 13 Assessment Period Recovery 1 477 Company Sanitized. Does not contain TSCA CBI J H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURE 7 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR MALE RATS 2000 n 1800 1600 ^ 1400 o a 1200 - c Baseline W eek 13 Assessment Period 0 mg/kg/day H 25 mg/kg/day H lOOmgkgday IM250 mg/kg/day 478 Does no, contain Recovery H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURE 8 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR FEMALE RATS 2000 n 1800 1600 - 0 mg/kg/day - 1125 m g/kg/day H 100 mgkgday 250 mg/kg/day Duration of Movements (sec) Baseline W eek 13 Assessment Period 479 Recovery SanIHzed. Does notcontain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURE 9 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR MALE RATS W eek 13 Assessment Period 480 D 0 mg/kg/day III25 mg/kg/day H 100mgkgday Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5368 FIGURE 10 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR FEMALE RATS Baseline I W eek 13 Assessment Period 0 mg/kg/day 11 25 m g/kg/day 1^ 100 mgkgday M250 mg/kg/day 481 Company Sanitized. Does not contain TSCA CBI Recovery H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDICES 482 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX A ANALYTICAL DATA 483 Company Sanitized. Does not contain TSCA CI3I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table I. Initial Homogeneity and Stability of H-24516 in Dosing Suspensions Sample Type mg/mL H-24516 Nominal Measured Test Day 0 Homogeneity Control 0.00 n d (a ) Top M id d l e Bottom 2.5 2.30 2.5 2.47 2.5 2.40 M ea n tB); 2.39+0.08 C .V .3% T op M iddle Bottom (c ) 10 8.97 10 10.2 10 14.0 M e a n tB): H .l + 2 .6 C .V .24% T op M id d l e B ottom 25 26.8 25 24.8 25 23.5 M ea n t* ): 25.01.6 C.V. 7% Percent Nominal 92.0 98.8 96.0 (95.6% ) 89.7 102.0 140.0 (111.0% ) 107.2 99.2 94.0 (100.0% ) Stability^ Test Day 6 Homogeneity Control T op M iddle B ottom 2.5 2.06 10 8.89 25 24.1 0.00 n d (a ) 10 9.26 10 9.58 10 9.23 M ea n t* ): 9.36+0.19 C .V .2% o 82.4 88.9 96.4 92.6 95.8 92.3 (93.6% ) Stability^ 10 9.03 90.3 (A) Denotes not detected. .. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation of top, middle, and bottom are based on measured concentration for each level. (C) Duplicate re-analysis o f original sample supports the original analysis and will not be reported. (D) Stability samples held 5 hours a room temperature. Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table ELMixing and Stability Study of H-24516 in Dosing Suspensions Sample Type mg/mL H-24516 Dose Volume Nominal Measured Homogeneity 7.5 mL/Kg . Control 0.00 n d (a ) Percent Nominal -- Top M iddle Bottom 5.0 mL/Kg Control 3.33 2.88 3.33 2.54 3.33 2.67 M earJP): 2.700.2 CV.6% 0.00 n d (a ) 86.5 76.3 80.2 (81.1% ) Top M iddle B ottom Top M iddle Bottom Top M iddle Bottom 5.0 5.0 5.0 20.0 20.0 20.0 50.0 50.0 50.0 4.53 4.25 4.39 M ea n f i: 4.39+0.14 C. V. 3 % 19.9 17.7 18.6 aW B ) ; i s . r i . i C.V. 6 % 53.4 52.6 54.0 M ea n f h 53.4+0.7 C.V. 1 % 90.6 85.0 87.8 (87.8% ) 99.5 88.5 93.0 (93.5% ) 106.8 105.2 108.0 (106.8% ) Stability 7.5 mL/Kg 0-Day Room T emperature 5-Hour Room T emperature 4-Day Refrigerated 3.33 2.70 3.33 2.66 3.33 2.94 3.33 2.88 Meart(C); 2 .9 1 + 0 .0 4 81.1 79.9 88.3 86.5 (87.4% ) C.V. 1% 4-D ay refrigerated/5 Hour RT 3.33 2.74 82.3 (A) Denotes not detected. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f duplicate samples are based on measured concentration for each level. oihpany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table II. Mixing and Stability Study of H-24516 in Dosing Suspensions (continued) Sample Type Dose Volume mg/mL H-24516 Nominal Measured Stability 5.0 mL/Kg 0-Day Room T emperature 5-Hour Room tem perature 2-D ay Refrigerated 5.0 4.39 5.0 4.60 5.0 4.77 5.0 4.76 M ean(C ):^70.01 3-Day R efrigerated 5.0 5.0 C.V. 0.2% 4.74 4.48 M ean(C ): 4.61+0.2 4-D ay Refrigerated 4-Day Refrigerated/5 H our RT 5.0 5.0 C .V .4% 4.81 4.85 Percent Nominal 87.8 92.0 95.4 95.2 (95.4% ) 94.8 89.6 (92.2% ) 96.1 97.1 0-Day Room T emperature 5-Hour Room T emperature 2-Day Refrigerated 3-Day Refrigerated 4-D ay Refrigerated 4-D ay Refrigerated/5 Hour RT 20.0 18.7 20.0 17.2 20.0 18.7 20.0 18.0 M ea n iQ : TM .30.5 C .V .3% 20.0 39.3 20.0 19.6 M ean (C V ): 29.4+14 C.V. 47% 20.0 19.6 20.0 17.6 93.5 86.0 93.5 90.0 (91.5% ) 196.4 97.8 (147.0% ) 97.8 88.2 0-Day Room T emperature 5-Hour Room T emperature 2-Day Refrigerated 50.0 53.4 50.0 48.3 50.0 47.3 50.0 48.4 M ea n iQ : 47.9+0.0 106.8 96.6 94.7 96.8 (95.8% ) 3-Day Refrigerated C.V. 2% 50.0 46.5 50.0 46.9 M e a n iQ : 46.7+0.3 93.0 93.8 (93.4% ) 4-D ay Refrig era ted 4-D ay Refrigerated/5 H our RT . 50.0 50.0 C .V .1% 48.9 47.9 97.8 95.7 (A) Denotes not detected. .. (B) The average measured concentration, average percent of nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation of duplicate samples are based on measured concentration for each level. (D) Result is the mean o f the duplicate re-analysis o f the original sample. Original analysis indicated aliquot error and will not be reported. 486 . Company SanWred. Doe* not c.n n W n TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table III. Final Homogeneity/Concentration Verification of H-24516 in Dosing Suspensions Sample Type mg/mL H-24516 Nominal Measured Percent Nominal Test Day 49 Homogeneity Control 0.00 n d (a ) T op M iddle Bottom T op M iddle B ottom T op M iddle Bottom * 3.33 3.33 3.33 13.33 13.33 13.33 33.33 33.33 33.33 2.71 2.99 3.42 M ean*?): 3-04 0 J C.V. 12 % 10.8 12.7 12.8 M eanV ): M eanW : ^ .1 1.1 C.V. 9% 31.0 32.4 33.4 ^.J7.2 C .V .4% 81.4 89.8 102.8 (91.3% ) 81.0 95.3 96.3 (90.8% ) 92.9 97.1 100.3 (96.8% ) Test Day 91 Control Homogeneity T op M id d l e Bottom 0.00 n d (a ) . 3.33 3.05 3.33 3.00 3.33 3.01 aW B ) ; 3 .0 2 + 0 .0 3 C.V. 1 % -- 91 .b 90.1 90.4 (90.7% ) Concentration Verification 13.33 13.33 M eaniC): 12.8 12.2 ^ .5 0 .4 C .V .3% 96.0 91.5 (93.8% ) 33.33 33.33 M ean iO : 32.7 323 ^ .5 0 .i C.V. 1% 98.1 96.6 (97.5% ) (A) Denotes not detected. .. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient of variation o f duplicate samples are based on measured concentration for each level. 48Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Figure 1 Representative Analytical Calibration Curve DuPont-5386 (a) 0) (c) . Figure 1: Calibration curve showing linear fit (line) to replicate peak height ratio measurements (squares) for calibration solutions of H-24516 diluted over a concentration range of 0.0302 to 0.1511 mg/mL. [(a) Retention time = 3.5 minutes, (b) Retention = 4.17 minutes, (c) Retention time = 4.77 minutes.] 488 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Figure 2 Reprsentative High Performance Liquid Chromatography Chromatograms Figure 2b: Representative GC chromatogram o f 2.5 m g/m L H-24516 dosing solution diluted to a nominal concentration o f 0.06 mg/mL. The measured concentration o f the representative solution is 2.51 mg/mL 489 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Figure 2 (continued) Representative High Performance Liquid Chromatography Chromatograms Figure 2c: Representative GC chromatogram of 0.0756 mg/mL H-24516 analytical reference solution. 490 Company Sanlttaed. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX B INDIVIDUAL DOSE VOLUMES (ML) 491 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (ML) EXPLANATORY NOTES DuPont-5386 Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co housed. Dose volumes administered during the cohabitation and post-mating periods are documented in the study records. Day 89 Last day o f test substance administration for male and female rats designated for one-month and 3-month recovery periods. p>ay 9 0 Last day o f test substance administration for male rats designated for the 90day exposure period. Day 92 Last day o f test substance administration for female rats designated for the 90-day exposure period. Footnotes a. Due to error, data are missing. b. Animal may not have received total dose. c. Due to error, rat was dosed with vehicle only. d. On test day 18, all male rats and the first 11 female rats in the 25 mg/kg/day group received 37-39 mg/kg/day. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extremis 492 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Male, I - 0 m g/kg/day 643241 2.8 2.8 643300 2.4 2.4 643143 2.4 2.4 643205 2.6 2.6 643235 2.8 2.8 643288 2.5 2.5 643150 2.4 2.4 643189 2.5 2.5 643185 2.5 2.5 643210 2.5 2.5 643268 2.6 2.6 643232 2 .6 2.6 643265 2.4 2.4 643239 2.7 2.7 643270 2.4 2.4 643148 2.5 2.5 643284 2.8 2.8 643229 2.4 2.4 643196 2.1 2.1 643176 2.5 2.5 643218 2.7 2.7 643207 2 . 4 -2.4 643280 2.3 2.3 643271 2.6 2.6 643211 2.5 2.5 643163 2.7 2.7 643197 2.5 2.5 643242 2.4 2.4 643251 2.4 2.4 643155 2.4 2.4 643147 2.5 2.5 643276 2.8 2.8 643237 2.4 2.4 643226 2.5 2.5 643195 2.4 2.4 643246 3.0 3.0 643253 2.4 2.4 643262 2.5 2.5 643172 2.6 2.6 643303 2.3 2.3 643304 2.1 2.1 643162 2.3 2.3 643254 2.2 a 643145 2.5 a 643204 2.7 a Day 2 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 Day 3 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.5 2.7 to to to to INDIVIDUAL DOSE VOLUME, Day 4 Day 5 Day 6 2.8 2.8 2.8 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.8 2.8 2.8 2.5 2.5 2.5 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.7 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.5 2.8 2.8 2.8 2.4 2.4 2.4 2.1 2.1 2.1 2.5 2.5 2.5 2.7 2.7 2.7 2.4 2.4 2.4 2.3 2.3 2.3 2.6 2.6 2.6 2.5 2.5 2.5 2.7 2.7 2.7 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.8 2.8 2.8 2.4 2.4 2.4 2.5 2.5 2.5 2.4 2.4 2.4 3.0 3.0 3.0 2.4 2.4 2.4 2.5 2.5 2.5 2.6 2.6 2.6 2.3 2.3 2.3 2.1 2.1 2.1 2.3 2.3 2.3 2.2 2.2 2.5 2.5 2.5 2.7 2.7 2.7 493 S (mL) Day 7 Day 8 Day 9 c DuPont-5386 Day 10 Day 11 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3 .4 3.2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 Company 3*nKh:ed Does not contain TSCA CBI \ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, I - 0 rag/kg/day 643241 3.5 3.5 643300 3.0 3.0 643143 2.9 2.9 643205 3.1 3.1 643235 3.5 3.5 643288 3.1 3.1 643150 2.9 2.9 643189 3.2 3.2 643185 3.2 3.2 643210 3.0 3.0 643268 3.2 3.2 643232 3.1 3.1 643265 2.9 2.9 643239 3.4 3.4 643270 2.9 2.9 643148 3.0 3.0 643284 3.4 3.4 643229 2.8 2.8 643196 2.6 2.6 643176 3.0 3.0 643218 3.1 3.1 643207 2.9 2 .9 643280 2.8 2.8 643271 3.2 3.2 643211 3.1 3.1 643163 3.4 3.4 643197 3.2 3.2 643242 3.1 3.1 643251 3.0 3.0 643155 2.9 2.9 643147 3.1 3.1 643276 3.5 3.5 643237 2.8 2.8 643226 2 .9 2 .9 643195 3.0 3.0 643246 3.6 3.6 643253 3.0 3.0 643262 3.1 3.1 643172 3.2 3.2 643303 2.9 2.9 643304 2.6 2.6 643162 2.8 2.8 643254 2.7 2.7 643145 2.9 2.9 643204 3.2 3.2 Day 14 4.1 3.5 3.4 3.6 4.1 3.6 3.4 3.8 3.8 3.5 3.8 3.4 3.4 3.8 3.4 3.5 3.9 3.2 3.0 3.5 3.6 3.3 3.4 3.8 3.5 3.9 3.6 3.6 3.5 3.5 3.6 4.2 3.2 3.4 3.5 4.3 3.5 3.7 3.7 3.4 3.0 3.3 3.1 3.3 3.7 INDIVIDUAL DOSE VOLUME! 15 Day 16 Day 17 Day 18 4.1 4.1 4.1 4.1 3.5 3.5 3.5 3.5 3.4 3.4 3.4 3.4 3.6 3.6 3.6 3.6 4.1 4.1 4.1 4.1 3.6 3.6 3.6 3.6 3.4 3.4 3.4 3.4 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.5 3.5 3.5 3.5 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.4 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.9 3.9 3.9 3.9 3.2 3.2 3.2 3.2 3.0 3.0 3.0 3.0 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.8 3.8 3.8 3.8 3.5 3.5 3.5 3.5 3.9 3.9 3.9 3.9 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.6 4.2 4.2 4.2 4.2 3.2 3.2 3.2 3.2 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 4.3 4.3 4.3 4.3 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.4 3.4 3.4 3.4 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 3.1 3.1 3.1 3.1 3.3 3.3 3.3 3.3 3.7 3.7 3.7 3.7 494 3 (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 4.1 4.1 4.5 4.5 4.5 3.5 3.5 3.9 3.9 3.9 3.4 3.4 3.8 3.8 3.8 3.6 3.6 4.1 4.1 4.1 4.1 4.1 4.6 4.6 4.6 3.6 3.6 4.1 4.1 4.1 3.4 3.4 3.6 3.6 3.6 3.8 3.8 4.3 4.3 4.3 3.8 3.8 4.2 4.2 4.2 3.5 3.5 3.9 3.9 3.9 3.8 3.8 4.3 4.3 4.3 3.4 3.4 3.8 3.8 3.8 3.4 3.4 4.0 4.0 4.0 3.8 3.8 4.3 4.3 4.3 3.4 3.4 3.8 3.8 3.8 3.5 3.5 3.8 3.8 3.8 3.9 3.9 4.3 4.3 4.3 3.2 3.2 3.5 3.5 3.5 3.0 3.0 3.3 3.3 3.3 3.5 3.5 3.9 3.9 3.9 3.6 3.6 4.0 4.0 4.0 3.3 3.3 3.6 3.6 3.6 3.4 3.4 3.8 3.8 3.8 3.8 3.8 4.3 4.3 3.5 3.5 3. 9 3.9 3 . 9 3 . 9 4.4 4.4 4.3 3.9 4.4 3.6 3.6 4.2 4.2 4.2 3.6 3.6 4.0 4.0 4. 0 3.5 3.5 3.9 3.9 3.9 3.5 3.5 3.9 3.9 3.9 3.6 3.6 4.0 4.0 4.0 4 .2 4 .2 4.7 4.7 4 . 7 3.2 3.2 3.6 3.6 3.6 3 .4 3 .4 3.7 3.7 3.7 3 . 5 3 . 5 3 . 8 3.8 3.8 4 . 3 4 .3 4.7 4.7 4.7 3 . 5 3 . 5 4 . 0 4.0 4 . 0 3.7 3.7 4 . 2 4 . 2 4 . 2 3.7 3.7 4 . 3 4 . 3 4 . 3 3.4 3.4 3.9 3.9 3.9 3.0 3.0 3.4 3.4 3.4 3.3 3.3 3.7 3.7 3.7 3 . 1 3 . 1 3.3 3.3 3.3 3.3 3.3 3.7 3.7 3.7 3.7 3.7 4 . 1 4 . 1 4 . 1 Company Sanitized. Does not contain TSCACBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, I - 0 m g/kg/day 643241 4.5 4.5 643300 3.9 3.9 643143 3.8 3.6 643205 4.1 4.1 643235 4.6 4.6 643288 4.1 4.1 643150 3.6 3.6 643189 4.3 4.3 643185 4.2 4.2 643210 3.9 3.9 643268 4.3 4.3 643232 3.8 3.8 643265 4.0 4.0 643239 4.3 4.3 643270 3.8 3.8 643148 3.8 3.8 643284 4.3 4.3 643229 3.5 3.5 643196 3.3 3.3 643176 3.9 3.9 643218 4.0 4.0 643207 3 .6 J3.6 643280 3.8 3.8 643271 4.3 4,3 643211 3.9 3.9 643163 4.4 4.4 643197 4.2 4.2 643242 4.0 4.0 643251 3 .9 3 .9 643155 3.9 3.9 643147 4.0 4.0 643276 4.7 4.7 643237 3.6 3.6 643226 3.7 3.7 643195 3.8 3.8 643246 4.7 4.7 643253 4.0 4.0 643262 4.2 4.2 643172 4.3 4.3 643303 3.9 3.9 643304 3.4 3.4 643162 3.7 3.7 643254 3.3 3.3 643145 3.7 3.7 643204 4.1 4.1 Day 26 4.5 3.9 3.8 4.1 4.6 4.1 3.6 4.3 4.2 3.9 4.3 3.8 4.0 4.3 3.8 3.8 4.3 3.5 3.3 3.9 4.0 3.6 3.8 4.3 3.9 4.4 4.2 4.0 3.9 3.9 4.0 4.7 3.6 3.7 3.8 4.7 4.0 4.2 4.3 3.9 3.4 3.7 3.3 3.7 4.1 Day 27 INDIVIDUAL DOSE VOLUME Day 28 Day 29 Day 30 4.5 3.9 3.8 4.1 4.6 4.1 3.6 4.3 4.2 3.9 4.3 3.8 4.0 4.3 3.8 3.8 4.3 3.5 3.3 3.9 4.0 3.6 3.8 4.3 3.9 4.4 4.2 4.0 3. 9 3.9 4.0 4.7 3.6 3.7 3.8 4.7 4.0 4.2 4.3 3.9 3.4 3.7 3.3 3.7 4.1 5.0 4.2 4.2 4.5 5.1 4.6 3.8 4.7 4.6 4.3 4.7 4.0 4.2 4.6 4.1 4.1 4.7 3.7 3.5 4.3 4.3 3.9 4.1 4.7 4.2 4.8 4.5 4.3 4.2 4.2 4.3 5.0 3.9 4.0 4.1 5.0 4.3 4.5 4.6 4.3 3.7 3.9 3.7 4.0 4.5 5.0 4.2 4.2 4.5 5.1 4.6 3.8 4.7 4.6 4.3 4.7 4.0 4.2 4.6 4.1 4.1 4.7 3.7 3.5 4.3 4.3 3.9 4.1 4.7 4.2 4.8 4.5 4.3 4.2 4.2 4.3 5.0 3.9 4.0 4.1 5.0 4.3 4.5 4.6 4.3 3.7 3.9 3.7 4.0 4.5 5.0 4.2 4.2 4.5 5.1 4.6 3.8 4.7 4.6 4.3 4.7 4.0 4.2 4.6 4.1 4.1 4.7 3.7 3.5 4.3 4.3 3.9 4.1 4.7 4.2 4.8 4.5 4.3 4.2 4.2 4.3 5.0 3.9 4.0 4.1 5.0 4.3 4.5 4.6 4.3 3.7 3.9 3.7 4.0 4.5 495 S (mL) Day 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 5.0 5.0 5.0 5.0 5.2 4.2 4.2 4.2 4.2 4.6 4.2 4.2 4.2 4.2 4.4 4.5 4.5 4.5 4.5 4.7 5.1 5.1 5.1 5.1 5.4 4.6 4.6 4.6 4.6 4.9 3.8 3.8 3.8 3.8 4.1 4.7 4.7 4.7 4.7 4.9 4.6 4.6 4.6 4.6 4.8 4.3 4.3 4.3 4.3 4.4 4.7 4.7 4.7 4.7 5.0 4.0 4.0 4.0 4.0 4.1 4.2 4.2 4.2 4.2 4.4 4.6 4.6 4.6 4.6 4.9 4.1 4.1 4.1 4.1 4.4 4.1 4.1 4.1 4.1 4.5 4.7 4.7 4.7 4.7 5.0 3.7 3.7 3.7 3.7 3.9 3.5 3.5 3.5 3.5 3.7 4.3 4.3 4.3 4.3 4.5 4.3 4.3 4.3 4.3 4.6 3.9 3.9 3.9 3.9 4.2 4.1 4.1 4.1 4.1 4.4 4.7 4.7 4.7 4.7 5.0 4.2 4.2 4.2 4.2 4.5 4.8 4.8 4.8 4.8 5.2 4.5 4.5 4.5 4.5 4.7 4.3 4.3 4.3 4.3 4.6 4.2 4.2 4.2 4.2 4.4 4.2 4.2 4.2 4.2 4.3 4.3 4.3 4.3 4.3 4.6 5.0 5.0 5.0 5.0 5.4 3.9 3.9 3.9 3.9 4.1 4.0 4.0 4.0 4.0 4.1 4.1 4.1 4.1 4.1 4.3 5.0 5.0 5.0 5.0 5.3 4.3 4.3 4.3 4.3 4.6 4.5 4.5 4.5 4.5 4.9 4.6 4.6 4.6 4.6 4.9 4.3 4.3 4.3 4.3 4.7 3.7 3.7 3.7 3.7 3.9 3.9 3.9 3.9 3.9 4.2 3.7 3.7 3.7 3.7 4.0 4.0 4.0 4.0 4.0 4.3 4.5 4.5 4.5 4.5 4.7 Company SanWzed. Does no! contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, I - 0 m g/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 5.2 4.6 4.4 4.7 5.4 4.9 4.1 4.9 4.8 4.4 5.0 4.1 4.4 4.9 4.4 4.5 5.0 3.9 3.7 4.5 4.6 4.2 4.4 5.0 4.5 5.2 4.7 4.6 4.4 4.3 4.6 5.4 4.1 4.1 4.3 5.3 4.6 4.9 4.9 4.7 3.9 4.2 4.0 4.3 4.7 5.2 4.6 4.4 4.7 5.4 4.9 4.1 4.9 4.8 4.4 5.0 4.1 4.4 4.9 4.4 4.5 5.0 3.9 3.7 4.5 4.6 -4.2 4.4 5.0 4.5 5.2 4.7 4.6 4.4 4.3 4.6 5.4 4.1 4.1 4.3 5.3 4.6 4.9 4.9 4.7 3.9 4.2 4.0 4.3 4.7 Day 38 3.9 3.4 3.3 3.5 4.0 3.7 3.1 3.7 3.6 3.3 3.8 3.1 3.3 3.7 3.3 3.3 3.8 2.9 2.8 3.4 3.4 3.2 3.3 3.7 3.3 3.9 3.5 3.5 3.3 3.2 3.5 4.1 3.0 3.1 3.2 4.0 3.4 3.7 3.7 3.5 2.9 3.1 3.0 3.3 3.5 INDIVIDUAL DOSE VOLUMES (mL) 39 Day 40 Day 41 3.9 3.4 3.3 3.5 4.0 3.7 3.1 3.7 3.6 3.3 3.8 3.1 3.3 3.7 3.3 3.3 3.8 2.9 2.8 3.4 3.4 3.2 3.3 3.7 3.3 3.9 3.5 3.5 3.3 3.2 3.5 4.1 3.0 3.1 3.2 4.0 3.4 3.7 3.7 3.5 2.9 3.1 3.0 3.3 3.5 3.9 3.4 3.3 3.5 4.0 3.7 3.1 3.7 3.6 3.3 3.8 3.1 3.3 3.7 3.3 3.3 3.8 2.9 2.8 3.4 3.4 3.2 3.3 3.7 3.3 3.9 3.5 3.5 3.3 3.2 3.5 4.1 3.0 3.1 3.2 4.0 3.4 3.7 3.7 * 3.5 2.9 3.1 3.0 3.3 3.5 3.9 3.4 3.3 3.5 4.0 3.7 3.1 3.7 3.6 3.3 3.8 3.1 3.3 3.7 3.3 3.3 3.8 2.9 2.8 3.4 3.4 3.2 3.3 3.7 3.3 3.9 3.5 3.5 3.3 3.2 3.5 4.1 3.0 3.1 3.2 4.0 3.4 3.7 3.7 3.5 2.9 3.1 3.0 3.3 3.5 42 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 Day 43 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 DuPont-5386 Day 44 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 496 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 Day 46 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 Day 47 INDIVIDUAL DOSE VOLUMES (mL) Day 4 8 Day 49 Day 50 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4. 1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 Day 51 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 UJ CD Day 52 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7' 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.B DuPont-5386 Day 53 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 497 Comnsny SanV ied. Does noi contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 Day 55 4 .3 3 .8 3 .6 3.9 4. 4 3.9 3 .2 3.9 3 .9 3 .7 4 .1 3 .4 3 .7 4 .1 3 .6 3 .6 4 .2 3.2 3.1 3.7 3.8 3. 4 3. 7 4. 2 3 .7 4 .3 3.9 3. 9 3 .6 3. 7 3 .8 4 .5 3 .3 3 ..6 3 .6 4. 3 3 .,8 4 ..1 4 ., 0 4 .. 0 3 .. 3 3.,3 3 ..3 3 .6 3 .. 8 INDIVIDUAL DC 56 Day 57 4.4 4.4 4.0 4.0 3.7 3.7 4.0 4.0 4.5 4.5 4.1 4.1 3.3 3.3 4.1 4.1 4.0 4.0 3.7 3.7 4.2 4.2 3.4 3.4 3.7 3.7 4.2 4.2 3.7 3.7 3.7 3.7 4.3 4.3 3.3 3.3 3.2 3.2 3.8 3.8 4.0 4.0 3.5 3.5 3.9 3.9 4.4 4.4 3.8 3.8 4.5 4.5 4.0 4.0 4.1 4.1 3.7 3.7 4.0 4.0 4.0 4.0 4.7 4.7 3.5 3.5 3.7 3.7 3.8 3.8 4.4 4.4 4.0 4.0 4.2 4.2 4.3 4.3 4.1 4.1 3.4 3.4 3.1 3.1 3.4 3.4 3.6 3.6 3.9 3.9 iSE VOLUMES (mL) Day 58 Day 59 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 Day 60 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4,4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 Day 61 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 I> D uP o n t-5 3 8 6 Day 62 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3 .4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3. 8 4.4 4.0 4.2 4.3 4.1 3.4 3. 1 3.4 3.6 3.9 498 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 63 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 64 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 65 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 66 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 67 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 68 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 69 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 70 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 DuPont-5386 Day 71 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 499 Company SanHteed. Does mrt contata TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 72 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 Day 73 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.2 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 Day 74 INDIVIDUAL DOSE VOLUMES (mL) Day 75 Day 76 Day 77 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.8 4.2 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.8 4.2 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 Day 78 Day 79 4.7b 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 DuPont-5386 Day 80 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 500 Company Smithed. Does noteortM nTSCACBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Day 81 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 Day 82 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 Day 83 INDIVIDUAL DOSE VOLUMES ( m L ) Day 84 Day 85 Day 86 4.7 4.8 4.8 4.8 4.4 4.5 4.5 4.5 3 . 9 3.9 3 . 9 3 . 9 4.3 4.4 4.4 4.4 4 . 8 4 . 9 4 . 9 4.9 4.5 4.6 4.6 4.6 3.6 3.6 3.6 3.6 4.5 4.6 4.6 4.6 4.4 4.5 4.5 4.5 4 . 0 4 . 1 4 . 1 4.1 4.3 4.4 4.4 4.4 3.8 3.9 3.9 3.9 3.8 3.8 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 2.8 3.7 4.2 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 Day 87 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 Day 88 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 DuPont-5386 Day 89 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 3.8 4.1 4.2 4.8 4.5 4.5 4.7 4.6 3.8 3.0 3.9 4.4 501 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 90 M a le , I - 0 m g /k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.8 4.5 3.9 4.4 5.0 4.5 3.7 4.7 4.6 4.5 DuPont-5386 502 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Day 2 Day 3 Day 5 Day 6 Day 1 Day 8 Day 9 Day 10 Day 11 M ale, I I I - 25 m g /k g /d a y 643173 643290 643272 643292 643226 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 - 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 c 2.6 c 2.2 c 2.1 c 2.5 c 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 to u> 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.6 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.8 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.8 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.8 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2. 9 3.2 3.3 2. 8 503 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 12 Day 13 Male, I I I - 25 m g /k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 3.3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.8 3.0 2.7 2.8 3.0 3.5 3.3 3.3 3.0 3.0 3.1 2.8 3.2 2.6 3.2 3.0 2.6 3.3 3.1 3.2 2.4 3.1 '3 .3 3.2 2.8 2.9 3.1 3.4 3.2 3.0 3.2 3.1 2.9 3.2 3.3 2.6 Day 14 Day 15 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.8 3.2 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.0 3.2 Day 16 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.8 3.2 Day 17 Day 18d 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 v> 4.0 b 3.8 3.4 3.8 3.6 3. 3 3.7 3.8 3.2 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3. 8 3.6 3.3 3.7 3.8 3.2 Day 19 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.8 3.2 Day 20 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3.8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.8 3.2 Day 21 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 Day 22 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4 .2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 i DuPont-5386 Day 23 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 504 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, I I I - 25 m g/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.8 3.8 3.6 3.6 3.5 3.5 3.9 3.9 4.5 4.5 4.2 4.2 4.3 4.3 3.8 3.8 4.0 4.0 4.1 4.1 3.6 3.6 4.1 4.1 3.3 3.3 4.0 4.0 3.9 3.9 3.4 3.4 4.4 4.4 3.8 3.8 4.1 4.1 3.3 3.3 4.2 4.2 4.2 - 4.2 4.2 4.2 3.7 3.7 3.8 3.8 4.0 4.0 4.5 4.5 4.2 4.2 3.7 3.7 4.2 4.2 3.9 3.9 3.6 3.6 4.0 4.0 4.2 4.2 3.6 3.6 Day 26 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 Day 27 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 INDIVIDUAL DOSE VOLUMES Day 28 Day 29 Day 30 4.2 4.2 4.2 4.0 4.0 4.0 3.9 3.9 3.9 4.2 4.2 4.2 4.9 4.9 4.9 4.6 4.6 4.6 4.7 4.7 4.7 4.1 4.1 4.1 4.4 4.4 4.4 4.4 4.4 4.4 3.8 3.8 3.8 4.5 4.5 4.5 3.7 3.7 3.7 4.2 4.2 4.2 4.2 4.2 4.2 3.7 3.7 3.7 4.8 4.8 4.8 4.1 4.1 4.1 4.5 4.5 4.5 3.7 3.7 3.7 4.6 4.6 4.6 4.6 4.6 4.6 4.5 4.5 4.5 4.1 4.1 4.1 4.2 4.2 4.2 4.4 4.4 4.4 4.9 4.9 4.9 4.6 4.6 4.6 3.8 3.8 3.8 4.5 4.5 4.5 4.2 4.2 4.2 3.8 3.8 3.8 4.4 4.4 4.4 4.6 4.6 4.6 3.9 3.9 3.9 505 3 (ml.) Day 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 4.2 4.2 4.2 4.2 4.7 4.0 4.0 4.0 4.0 4.3 3.9 3.9 3.9 3.9 4.1 4.2 4.2 4.2 4.2 4.6 4.9 4.9 4.9 4.9 5.4 4.6 4.6 4.6 4.6 5.0 4.7 4.7 4.7 4.7 5.0 4.1 4.1 4.1 4.1 4.3 4.4 4.4 4.4 4.4 4.8 4.4 4.4 4.4 4.4 4.6 3.8 3.8 3.8 3.8 4.1 4.5 4.5 4.5 4.5 4.8 3.7 3.7 3.7 3.7 3.9 4.2 4.2 4.2 4.2 4.6 4.2 4.2 4.2 4.2 4.6 3.7 3.7 3.7 3.7 4.0 4.8 4.8 4.8 4.8 5.1 4.1 4.1 4.1 4.1 4.3 4.5 4.5 4.5 4.5 4.8 3.7 3.7 3.7 3.7 3.9 4.6 4.6 4.6 4.6 4.9 4.6 4.6 4.6 4.6 4.9 4.5 4.5 4,5 4.5 4.9 4 . 1 4 . 1 4 . 1 4 . 1 4.4 4 .2 4 .2 4 .2 4 . 2 4.5 4.4 4.4 4.4 4.4 4 . 7 4.9 4.9 4.9 4.9 5.2 4 .6 4 . 6 4 . 6 4 . 6 4.9 3.8 3.8 3.8 3.8 4.0 4.5 4.5 4.5 4.5 4.9 4 . 2 4 . 2 4 . 2 4 . 2 4.4 3 .8 3 .8 3 .8 3 .8 4.1 4.4 4.4 4.4 4.4 4.8 4.6 4.6 4.6 4.6 4.9 lU ID 3.9 3 . 9 3.9 4.2 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, I I I - 25 m g /k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 4.7 4.3 4.1 4.6 5.4 5.0 5.0 4.3 4.8 4.6 4.1 4.8 3.9 4.6 4.6 4.0 5.1 4.3 4.8 3.9 4.9 4.9 4.9 4.4 4.5 4.7 5.2 4.9 4.0 4.9 4.4 4.1 4.8 4.9 4.2 4.7 4.3 4.1 4.6 5.4 5.0 5.0 4.3 4.8 4.6 4.1 4.8 3.9 4.6 4.6 4.0 5.1 4.3 4.8 3.9 4.9 - 4.9 4.9 4.4 4.5 4.7 5.2 4.9 4.0 4.9 4.4 4.1 4.8 4.9 4.2 Day 38 3.5 3.2 3.1 3 .4 4.1 3.7 3.8 3.3 3.6 3.5 3.1 3.6 2.9 3.4 3.5 3.0 3.8 3.3 3.6 2.9 3.7 3.7 3.7 3.3 3.4 3.6 3.9 3.7 3.0 3.7 3.3 3.1 3.6 3.7 3.1 INDIVIDUAL DOSE VOLUMES (mL) 39 Day 40 Day 41 D a y 4 2 3.5 3.2 3.1 3.4 4.1 3.7 3.8 3.3 3.6 3.5 3.1 3.6 2.9 3.4 3.5 3.0 3.8 3.3 3.6 2.9 3.7 3.7 3.7 3.3 3.4 3.6 3.9 3.7 3.0 3.7 3.3 3.1 3.6 3.7 3.1 3.5 3.2 3.1 3.4 4.1 3.7 3.8 3.3 3.6 3.5 3.1 3.6 2.9 3.4 3.5 3.0 3.8 3.3 3.6 2.9 3.7 3.7 3.7 3.3 3.4 3.6 3.9 3.7 3.0 3.7 3.3 3.1 3.6 3.7 3.1 3.5 3.2 3.1 3.4 4.1 3.7 3.8 3.3 3.6 3.5 3.1 3.6 2.9 3.4 3.5 3.0 3.8 3.3 3.6 2.9 3.7 3.7 3.7 3.3 3.4 3.6 3.9 3.7 3.0 3.7 3.3 3.1 3.6 3.7 3.1 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.6 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 Day 43 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 DuPont-5386 Day 44 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3-1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 506 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Day 46 Male, I I I - 25 m g/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0. 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 Day 47 INDIVIDUAL DC Day 48 3.6 3.6 3.5 3.5 3.3 3.3 3.6 3.6 4.2 4.2 3.9 3.9 4.0 4.0 3.3 3.3 3.8 3.8 3.6 3.6 3.2 3.2 3.7 3.7 3.1 3.1 3.5 3.5 3.6 3.6 3.1 3.1 3.9 3.9 3.3 3.3 3.7 3.7 3.1 3.1 3.9 3.9 3.8 3.8 3.8 3.8 3.4 3.4 3.5 3.5 3.7 3.7 4.0 4.0 3.9 3.9 3.1 3.1 3.8 3.8 3.5 3.5 3.2 3.2 3.8 3.8 3.8 3.8 3.2 3.2 ISE VOLUMES (mL) Day 4 9 Day 50 3.7 3.7 3.5 3.5 3.3 3.3 3.7 3.7 4.3 4.3 4.0 4.0 4.0 4.0 3.3 3.3 3.9 3.9 3.6 3.6 3.4 3.4 3.8 3.8 3.1 3.1 3.7 3.7 3.7 3.7 3.2 3.2 4.1 4.1 3.5 3.5 3.8 3.8 3.2 3.2 4.0 4.0 3.8 3.8 3.9 3.9 3.6 3.6 3.5 3.5 3.9 3.9 4.2 4.2 4.0 4.0 3.2 3.2 3.8 3.8 3.6 3.6 3.2 3.2 4.0 4.0 4.0 4.0 3 . 4 3.4 Day 51 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3. B 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Day 52 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 % DuPont-5386 Day 53 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 507 D oes not contain TSCA 08 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, I I I - 25 m g/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Day 56 INDIVIDUAL DO; Day 57 3.8 3.8 3.8 3.8 3.4 3.4 3.8 3.8 4.5 4.5 4.1 4.1 4.2 4.2 3.4 3 .4 4.0 4.0 3.7 3.7 3.3 3.3 3.9 3.9 3.2 3.2 3.7 3.7 3.9 3.9 3.3 3.3 4.4 4.4 3.6 3.6 3.9 3.9 3.3 3.3 4.1 4.1 4.0 4.0 4.1 4.1 3.8 3.8 3.7 3.7 4.0 4.0 4.4 4.4 4.1 4.1 3.3 3.3 3.9 3.9 3.7 3.7 2.9 2.9 4.1 4.1 4.1 4.1 3.5 3.5 SE VOLUMES (mL) Day 58 Day 59 3.8 3.8 3.8 3.8 3.4 3.4 3.8 3.8 4.5 4.5 4.1 4.1 4.2 4.2 3.4 3.4 4.0 4.0 3.7 3.7 3.3 3.3 3.9 3-9 3.2 3.2 3.7 3.7 3.9 3.9 3.3 3.3 4.4 4.4 3.6 3.6 3.9 3.9 3.3 3.3 4.1 4.1 4.0 4.0 4.1 4.1 3.8 3.8 3.7 3.7 4.0 4.0 4.4 4.4 4.1 4.1 3.3 3.3 3.9 3.9 3.7 3.7 2.9 2.9 4.1 4.1 4.1 4.1 3.5 3.5 Day 60 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 Day 61 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3-3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 4 DuPont-5386 Day 62 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 508 Company Sanitized. Does not contain TSCA CBI ' ? t,,.,| H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________ Day 63 Day 64 Male, I I I 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 25 m g/kg/day 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 4.2 4.3 3.6 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 4.2 4.3 3.6 Day 65 INDIVIDUAL DOSE VOLUMES (mL ) Day 66 Day 67 Day 68 3 . 9 3 . 9 3 . 9 3.9 3.9 3.9 3.7 3 . 9 3.9 3.7 3.7 3.9 3.9 3.9 3.9 4.7 4 .7 4 .7 4.7 4.2 4 . 2 4 . 2 4.2 4.4 4 . 4 4 . 4 4.4 3.5 4.2 3 . 5 3.5 4 . 2 4.2 3.7 3 . 7 3 .7 3.7 3.4 3.4 3 . 4 3.4 4.0 4.0 4 .0 4.0 3.2 3.2 3 .2 3.2 3.8 3.8 3 . 8 3.8 4.1 4.1 4 .1 4.1 3.4 3.4 3 . 4 3.4 4.5 4.5 4 .5 4.5 3.7 3 . 7 3 . 7 3. 7 4.1 4.1 4 . 1 4. 1 3.4 3.4 3 . 4 3.4 4.4 4.4 4 . 4 4.4 4.1 4.3 4.1 4.3 4.1 4.3 4.1 4.3 3.9 3.9 3 . 9 3.9 3.8 3.8 3 . 8 3.8 4.1 4.1 4 .1 4.1 4.4 4.4 4 . 4 4.4 4.3 4.3 4 . 3 4.3 3.2 3.2 3 . 2 3.2 4.0 4.0 4 .0 4.0 3.8 3.8 3 . 8 3.8 3.3 3.3 3 . 3 3.3 4.2 4.2 4 .2 4.2 4.3 4.3 4 . 3 4.3 3.6 3 . 6 3 . 6 3.6 Day 69 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 4.2 4.3 3.6 Day 70 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 DuPont-5386 Day 71 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3-3 4.2 3.9 3.5 4.3 4.4 3.7 509 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 72 Day 73 Male, I I I 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261. 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 in CN mg/kg/day 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 74 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 Day 75 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 Day 76 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 Day 77 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 Day 78 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 Day 79 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 DuPont-5386 Day 80 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 510 Company SanWzed. Does not contain TSCA CW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 81 Day 82 Day 83 INDIVIDUAL DOSE VOLUMES (mL) Day 84 Day 85 Day 86 M ale, I I I - 25 m g /k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 Day 87 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 DuPont-5386 Day 88 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 Day 89 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 511 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 90 Male, I I I - 25 m g/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.9 4.3 4.1 4.1 5.2 4.7 4.9 3.8 4.3 4.1 DuPont-5386 512 Company S sn f'ved. Does not contain TSCA CBI 1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ____________ DuPont-5386 Day 0 Day 1 Day 2 Day 3 INDIVIDUAL DOSE VOLUMES (mL) Day 4 Day 5 Day 6 Day 7 Day 8 Day 9 Day 10 Day 11 Male, V - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2 .4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.1 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 513 Company Santtbed. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Male, V 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 INDIVIDUAL DOSE VOLUMES (mL) 12 D a y 13 D a y 14 D a y 15 D a y 16 D a y 17 D a y 18 D a y 19 D a y 20 Day 21 Day 22 Day 23 ) mg/kg/day 2.8 2.9 3.0. 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.B 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 514 Company Sanitized. Doe* not contain TSCA CBI ) tw H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Day 24 Day 25 Male, V - 100 m g/kg/da y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 - 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 Day 26 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 INDIVIDUAL DOSE VOLUMES (mL) 27 Day 28 Day 29 Day 30 31 Day 32 Day 33 Day 34 Day 35 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 3.9 4.2 4.2 4.6 4.6 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 3.9 4.2 4.2 4.6 4.8 4.5 4.3 4.5 4.1 4.0 4.0 4.3 3.6 4.4 3.8 3.9 4.6 4.5 4.0 4.7 4.5 4.9 4.3 3.8 4.4 4.4 4.6 4.2 4.1 4.5 4.7 4.2 4.7 4.1 4.5 4.0 4.5 4.4 4.9 5.0 4.8 4.5 4.7 4.4 4.2 4.2 4.7 3.9 4.6 4.0. 4.2 5.0 4.8 4.2 4.8 4.8 5.2 4.5 3.9 4.7 4.7 4.8 4.5 4.3 4.7 5.0 4.4 4.9 4.3 4.8 515 Company Sanitized. Does not contain TSCACBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 36 Day 37 Male, V - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 4.0 4.5 4.4 4.9 5.0 4.8 4.5 4.7 4.4 4.2 4.2 4.7 3.9 4.6 4.0 4.2 5.0 4.8 4.2 4.8 4.8 5.2 4.5 3.9 4.7 4.7 4.8 4.5 4.3 4.7 5.0 4.4 4.9 4.3 4.8 5.9 4.5 4.4 4.9 5.0 4.8 4.5 4.7 4.4 4.2 4.2 4.7 3.9 4.6 4.0 4.2 5.0 4.8 4.2 4.8 4.8 5.2 4.5 3.9 4.7 4.7 4.8 4.5 4.3 4.7 5.0 4.4 4.9 4.3 4.8 Day 38 3.0 3.4 3.3 3.7 3.7 3.6 3.4 3.5 3.3 3.2 3.2 3.5 2.9 3.5 3.0 3.2 3.7 3.6 3.1 3.6 3.6 3.9 3.4 2.9 3.5 3.5 3.6 3.4 3.3 3.5 3.7 3.3 3.7 3.3 3.6 Day 39 3.0 3.4 3.3 3.7 3.7 3.6 3.4 3.5 3.3 3.2 3.2 3.5 2.9 3.5 3.0 3.2 3.7 3.6 3.1 3.6 3.6 3.9 3.4 2.9 3.5 3.5 3.6 3.4 3.3 3.5 3.7 3.3 3.7 3.3 3.6 Day 40 3.0 3.4 3.3 3.7 3.7 3.6 3.4 3.5 3.3 3.2 3.2 3.5 2.9 3.5 3.0 3.2 3.7 3.6 3.1 3.6 3.6 3.9 3.4 2.9 3.5 3.5 3.6 3.4 3.3 3.5 3.7 3.3 3.7 3.3 3.6 Day 41 3.0 3.4 3.3 3.7 3.7 3.6 3.4 3.5 3.3 3.2 3.2 3.5 2.9 3.5 3.0 3.2 3.7 3.6 3.1 3.6 3.6 3.9 3.4 2.9 3.5 3.5 3.6 3.4 3.3 3.5 3.7 3.3 3.7 3.3 3.6 Day 42 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3.4 3.8 Day 43 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3.4 3.8 DuPont-5386 Day 44 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3 .4 3.8 516 ' n,t,P, iy Sanitized. Doe* "o* contain TSCACBI H-24516; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 4 5 Day 46 M a l e , V -- 1 0 0 m g / k g / d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3 .4 3.9 3.4 3.8 31 35 35 38 39 38 36 37 34 33 33 36 31 37 31 33 39 37 32 37 3e 4i 35 30 3 ,6 37 3 .8 36 3 ,5 3 ,8 3 .9 3 ,4 3 ,9 3 .4 3 .8 INDIVIDUAL DC 47 Day 48 3.1 3.1 3.5 3.5 3.5 3.5 3.8 3.8 3.9 3.9 3.8 3.8 3.6 3.6 3.7 3.7 3.4 3.4 3.3 3.3 3.3 3.3 3.6 3.6 3.1 3.1 3.7 3.7 3.1 3.1 3.3 3.3 3.9 3.9 3.7 3.7 3.2 3.2 3.7 3.7 3.8 3.8 4.1 4.1 3.5 3.5 3.0 3.0 3.6 3.6 3.7 3.7 3.8 3.8 3.6 3.6 3.5 3.5 3.8 3.8 3.9 3.9 3.4 3.4 3.9 3.9 3.4 3.4 3.8 3.8 >SE VOLUMES (mL) Day 4 9 Day 50 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 Day 51 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 Day 52 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 DuPont-5386 Day 53 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3 .e 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 517 Com pany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, v - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 Day 56 INDIVIDUAL DC Day 57 3.3 3.3 3.7 3.7 3.6 3.6 4.0 4.0 3.8 3.8 4.0 4.0 3.8 3.8 3.9 3.9 3.6 3.6 3.4 3.4 3.4 3.4 3.9 3.9 3.4 3.4 4.0 4.0 3.3 3.3 3.6 3.6 4.1 4.1 4.0 4.0 3.5 3.5 3.9 3.9 4.0 4.0 4.3 4.3 3.7 3.7 3.3 3.3 3.9 3.9 4.0 4.0 4.2 4.2 3.9 3.9 3.8 3.8 4.1 4.1 4.2 4.2 3.7 3.7 4.3 4.3 3.8 3.8 4.0 4.0 ) i ISE VOLUMES (mL) Day 58 Day 59 3.3 3.3 3.7 3.7 3.6 3.6 4.0 4.0 3.8 3.8 4.0 4.0 3.8 3.8 3.9 3.9 3.6 3.6 3.4 3 .4 3.4 3.4 3.9 3.9 3.4 3.4 4.0 4.0 3.3 3.3 3.6 3.6 4.1 4.1 4.0 4.0 3.5 3.5 3.9 3.9 4.0 4.0 4.3 4.3 3.7 3.7 3.3 3.3 3.9 3.9 4.0 4.0 4.2 4.2 3.9 3.9 3.8 3.8 4.1 4.1 4.2 4.2 3.7 3.7 4.3 4.3 3.8 3.8 4.0 4.0 Day 60 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 Day 61 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 DuPont-5386 Day 62 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 518 Company Sanitized. Does not eontaln TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 63 Day 64 Male, V - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4. 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 65 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 66 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 67 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3 .4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 68 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 69 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 70 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 D uPont-5386 Day 71 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 519 Company Sanitized. Does not contain TSCA CH H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 72 Day 73 Day 74 INDIVIDUAL DOSE VOLUMES (mL) Day 75 Day 76 77 Day CO r- Male, V - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.5 3.5 4.1 4.1 3.8 3.8 4.3 4.3 4.2 4.2 AK TEST DAY 7 7 4.0 4.0 4.2 4.2 3.8 3.8 3.6 3.6 3.6 3.6 4.1 4.1 3.7 3.7 4.4 4.4 3.5 3.5 Day 79 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 t' DuPont-5386 Day 80 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 520 Company Stmltteed. D o e s n ot con tain TSCACW H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Male, V 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 Day 81 Day 82 100 m g/kg/day 3.5 3.5 4.1 4.1 3.8 3.8 4.3 4.3 4.2 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4 .4b 3.5 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 Day 83 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 Day 84 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 85 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 86 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 87 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 88 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3 ,'s 4.0 3.8 4.5 3.7 DuPont-5386 Day 89 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 521 Company Sanitized. Does nof contain T8CA CW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (mL) Day 90 Male, V - 100 m g/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.7 4.2 3.9 4.4 4.3 4.0 4.1 3.9 3.7 DuPont-5386 522 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL DOSE VOLUMES (mL) Day 0 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Day 8 Day 9 Day 10 Day 11 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2,4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 - 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 3.0 2.9 2.8 2.9 3.3 3.4 3.3 3.3 2.9 3.5 2.9 3.1 2.7 3.5 3.0 2.7 3.3 3.4 3.1 3.2 3.7 3.1 3.1 2.9 3.0 3.0 3.2 3.2 3.0 3.4 3.2 3.5 3.0 3.0 3.3 3.4 3.0 3.0 3.1 3.1 3.0 3.1 2.8 3.4 3.0 3.0 2.9 2.8 2.9 3.3 3.4 3.3 3.3 2.9 3.5 2.9 3.1 2.7 3.5 3.0 2.7 3.3 3.4 3.1 3.2 3.7 3.1 3.1 2.9 3.0 3.0 3.2 3.2 3.0 3.4 3.2 3.5 3.0 3.0 3.3 3.4 3.0 3.0 3.1 3.1 3.0 3.1 2.8 3.4 3.0 3.0 2.9 2.8 2.9 3.3 3.4 3.3 3.3 2.9 3.5 2.9 3.1 2.7 3.5 3.0 2.7 3.3 3.4 3.1 3.2 3.7 3.1 3.1 2.9 3.0 3.0 3.2 3.2 3.0 3.4 3.2 3.5 3.0 3.0 3.3 3.4 3.0 3.0 3.1 3.1 3.0 3.1 2.8 3.4 3.0 3.0 2.9 2.8 2.9 3.3 3.4 3.3 3.3 2.9 3.5 2.9 3.1 2.7 h 3.5 b 3.0 2.7 3.3 3.4 3.1 3.2 3.7 3.1 3.1 2.9 3.0 3.0 3.2 3.2 3.0 3.4 3.2 3.5 3.0 3.0 3.3 3.4 3.0 3.0 3.1 3.1 3.0 3.1 2.8 3.4 3.0 3.0 2.9 2.8 2.9 3.3 3.4 3.3 3.3 2.9 3.5 2.9 3.1 2.7 3.5 3.0 2.7 3.3 3.4 3.1 3.2 3.7 3.1 3.1 2.9 3.0 3.0 3.2 3.2 3.0 3.4 3.2 3.5 3.0 3.0 3.3 3.4 3.0 3.0 3.1 3.1 3.0 3.1 2.8 3 .4 3.0 523 Company Sanitized. Doe* not contata TSCA CBI i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.0 3.0 2.9 2.9 2.8 2.8 2.9 2.9 3.3 3.3 3.4 3.4 3.3 3.3 3.3 3.3 2.9 2.9 3.5 3.5 2.9 2.9 3.1 3.1 2.7 2.7 3.5 3.5 3.0 3.0 2.7 2.7 3.3 3.3 3.4 3.4 3.1 3.1 3.2 3.2 3.7 3.7 3.1 -3.1 3.1 3.1 2.9 2.9 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3.0 3.0 3.4 3.4 3.2 3.2 3.5 3.5 3.0 3.0 3.0 3.0 3.3 3.3 3.4 3.4 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.0 3.0 3.1 3.1 2.8 2.8 3.4 3.4 3.0 3.0 Day 14 3.4 3.3 3.2 3.3 3.7 3.8 3.8 3.8 3.4 3.9 3.4 3.6 3.1 4.1 3.4 3.1 3.9 3.9 3.6 3.6 4.2 3.5 3.5 3.4 3.5 3.5 3.7 3.7 3.3 3.8 3.7 4.1 3.5 3.5 3.7 3.9 3.5 3.5 3.6 3.6 3.5 3.7 3.3 3.8 3.4 INDIVIDUAL DOSE VOLUME 15 Day 16 Day 17 Day 18 3.4 3.4 3.4 3.4 3.3 3.3 3.3 3.3 3.2 3 .2 3.2 3.2 3.3 3.3 3.3 3.3 3.7 3.7 3.7 3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 3.9 3.9 3.9 3.9 3.4 3.4 3.4 3.4 3.6 3.6 3.6 3.6 3.1 3.1 3.1 3.1 4.1 4.1 4.1 4.1 3.4 3.4 3.4 3.4 3.1 3.1 3.1 3.1 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.9 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 4.2 4.2 4.2 4.2 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.3 3.3 3.3 3.3 3.8 3.8 3.8 3.8 3.7 3.7 3.7 3.7 4.1 4.1 4.1 4.1 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.9 3.9 3.9 3.9 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.3 3.3 3.3 3.3 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 524 S (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 3.4 3.3 3.2 3.3 3.7 3.8 3.8 3.8 3.4 3.9 3.4 3.6 3.1 4.1 3 .4 3.1 3.9 3.9 3.6 3.6 4.2 3.5 3.5 3.4 3.5 3.5 3.7 3.7 3.3 3.8 3.7 4.1 3.5 3.5 3.7 3.9 3.5 3.5 3.6 3.6 3.5 3.7 3.3 3.8 3.4 3.4 3.3 3.2 3.3 3.7 3.8 3.8 3.8 3.4 3.9 3.4 3.6 3.1 4.1 3.4 3.1 3.9 3.9 3.6 3.6 4.2 3.5 3.5 3.4 3.5 3.5 3.7 3.7 3.3 3.8 3.7 4.1 3.5 3.5 3.7 3.9 3.5 3.5 3.6 3.6 3.5 3.7 3.3 3.8 3.4 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3.9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3.9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3.9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 Company Sanitized. Doe* no! contain TSCA CW H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.8 3.8 3.7 3.7 3.5 3.5 3.7 3.7 4.2 4.2 4.3 4.3 4.2 4.2 4.3 4.3 3.9 3.9 4.5 4.5 3.7 3.7 4.0 4.0 3.4 3.4 4.6 4.6 3.8 3.8 3.5 3.5 4.5 4.5 4.4 4.4 3.9 3.9 4.2 4.2 4.7 4.7 3.9 -3.9 3.9 3.9 3.8 3.8 3.9 3.9 3.9 3.9 4.2 4.2 4.1 4.1 3.8 3.8 4.2 4.2 4.2 4.2 4.7 4.7 3.9 3.9 3.9 3.9 4.1 4.1 4.4 4.4 4.0 4.0 4.0 4.0 4.0 4.0 4.1 4.1 4.0 4.0 4.1 4.1 3.6 3.6 4.3 4.3 3.9 3.9 Day 26 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3.9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 INDIVIDUAL DOSE VOLUMES 27 Day 28 Day 2 9 Day 30 3.8 4.1 4.1 4.1 3.7 4.0 4.0 4.0 3.5 3.8 3.8 3.8 3.7 4.0 4.0 4.0 4.2 4.5 4.5 4.5 4.3 4.6 4.6 4.6 4.2 4.5 4.5 4.5 4.3 4.6 4.6 4.6 3.9 4.3 4.3 4.3 4.5 4.9 4.9 4.9 3.7 4.0 4.0 4.0 4.0 4.4 4.4 4.4 3.4 2.9 2.9 2.9 4.6 5.0 5.0 5.0 3.8 4.1 4.1 4.1 3.5 3.8 3.8 3.8 4.5 4.8 4.8 4.8 4.4 4.6 4.6 4.6 3.9 4.2 4.2 4.2 4.2 4.5 4.5 4.5 4.7 5.0 5.0 5.0 3.9 4.2 4.2 4.2 3.9 4.2 4.2 4.2 3.8 4.1 4.1 4.1 3.9 4.2 4.2 4.2 3.9 4.2 4.2 4.2 4.2 4.6 4.6 4.6 4.1 4.4 4.4 4.4 3.8 4.0 4.0 4.0 4.2 4.4 4.4 4.4 4.2 4.5 4.5 4.5 4.7 5.1 5.1 5.1 3.9 4.2 4.2 4.2 3.9 4.2 4.2 4.2 4.1 4.3 4.3 4.3 4.4 4.7 4.7 4.7 4.0 4.3 4.3 4.3 4.0 4.3 4.3 4.3 4.0 4.3 4.3 4.3 4.1 4.5 4.5 4.5 4.0 4.3 4.3 4.3 4.1 4.5 4.5 4.5 3.6 4.0 4.0 4.0 4.3 4.6 4.6 4.6 3.9 4.2 4.2 4.2 525 (mL) 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 4.1 4.1 4.1 4.1 4.3 4.0 4.0 4.0 4.0 4.3 3.8 3.8 3.8 3.8 4.0 4.0 4.0 4.0 4.0 4.3 4.5 4.5 4.5 4.5 4.7 4.6 4.6 4.6 4.6 4.8 4.5 4.5 4.5 4.5 4.8 4.6 4.6 4.6 4.6 4.9 4.3 4.3 4.3 4.3 4.5 4.9 4.9 4.9 4.9 5.2 4.0 4.0 4.0 4.0 4.2 4.4 4.4 4.4 4.4 4.7 2.9 2.9 2.9 2.9 3.2 5.0 5.0 5.0 5.0 5.3 4.1 4.1 4.1 4.1 4.3 3.8 3.8 3.8 3.8 4.0 4.8 4.6 4.6 4.8 5.1 4.6 4.6 4.6 4.6 4.9 4.2 4.2 4.2 4.2 4.6 4.5 4.5 4.5 4.5 4.9 5.0 5.0 5.0 5.0 5.3 4.2 4.2 4.2 4.2 4.4 4.2 4.2 4.2 4.2 4.4 4.1 4.1 4.1 4.1 4.3 4.2 4.2 4.2 4.2 4.4 4.2 4.2 4.2 4.2 4.5 4.6 4.6 4.6 4.6 4.9 4.4 4.4 4.4 4.4 4.7 4.0 4.0 4.0 4.0 4.2 4.4 4.4 4.4 4.4 4.6 4.5 4.5 4.5 4.5 4.8 5.1 5.1 5.1 5.1 5.4 4.2 4.2 4.2 4.2 4.5 4.2 4.2 4.2 4.2 4.5 4.3 4.3 4.3 4.3 4.5 4.7 4.7 4.7 4.7 5.0 4.3 4.3 4.3 4.3 4.6 4.3 4.3 4.3 4.3 4.6 4.3 4.3 4.3 4.3 4.5 4.5 4.5 4.5 4.5 4.5 4.3 4.3 4.3 4.3 4.6 4.5 4.5 4.5 4.5 4.8 4.0 4.0 4.0 4.0 4.2 4.6 4.6 4.6 4.6 4.9 4.2 4.2 4.2 4.2 4.5 Company Sanitized. Does not contain TSCACBi H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643205 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 4.3 4.3 4.0 4.3 4.7 4.8 4.8 4.9 4.5 5.2 4.2 4.7 3.2 5.3 4.3 4.0 5.1 4.9 4.6 4.9 5.3 4.4 4.4 4.3 4.4 4.5 4.9 4.7 4.2 4.6 4.8 5.4 4.5 4.5 4.5 5.0 4.6 4.6 4.5 4.5 4.6 4.8 4.2 4.9 4.5 4.3 4.3 4.0 4.3 4.7 4.8 4.8 4.9 4.5 5.2 4.2 4.7 3.2 5.3 4.3 4.0 5.1 4.9 4.6 4.9 5.3 .4.4 4.4 4.3 4.4 4.5 4.9 4.7 4.2 4.6 4.8 5.4 4.5 4.5 4.5 5.0 4.6 4.6 4.5 4.5 4.6 4.8 4.2 4.9 4.5 Day 38 3.2 3.3 3.0 3.2 3.5 3.6 3.6 3.7 3.4 3.9 3.1 3.5 2.4 4.0 3.2 3.0 3.8 3.7 3.5 3.6 4.0 3.3 3.3 3.2 3.3 3.4 3.7 3.5 3.2 3.5 3.6 4.0 3.3 3.3 3.4 3.7 3.4 3.4 3.4 3.4 3.5 3.6 3.1 3.7 3.4 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 41 Day 42 3.2 3.3 3.0 3.2 3.5 3.6 3.6 3.7 3.4 3.9 3.1 3.5 2.4 4.0 3.2 3.0 3.8 3.7 3.5 3.6 4.0 3.3 3.3 3.2 3.3 3.4 3.7 3.5 3.2 3.5 3.6 4.0 3.3 3.3 3.4 3.7 3.4 3.4 3.4 3.4 3.5 3.6 3.1 3.7 3.4 3.2 3.3 3.0 3.2 3.5 3.6 3.6 3.7 3.4 3.9 3.1 3.5 2.4 4.0 3.2 3.0 3.B 3.7 3.5 3.6 4.0 3.3 3.3 3.2 3.3 3.4 3.7 3.5 3.2 3.5 3.6 ' 4.0 3.3 3.3 3.4 3.7 3.4 3.4 3.4 3.4 3.5 3.6 3.1 3.7 3.4 3.2 3.3 3.0 3.2 3.5 3.6 3.6 3.7 3.4 3.9 3.1 3.5 2.4 4.0 3.2 3.0 3.8 3.7 3.5 3.6 4.0 3.3 3.3 3.2 3.3 3.4 3.7 3.5 3.2 3.5 3.6 4.0 3.3 3.3 3.4 3.7 3.4 b 3.4 3.4 3.4 3.5 3.6 3.1 3.7 3.4 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 Day 43 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 DuPont-5386 Day 44 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 , 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.9 3.7 3.3 3.6 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 526 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Day 46 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643270 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 Day 47 INDIVIDUAL DC Day 48 3.4 3.4 3.4 3.4 3.1 3.1 3.4 3.4 3.6 3.6 3.8 3.8 3.7 3.7 3.9 3.9 3.6 3.6 4.0 4.0 3.2 3.2 3.7 3.7 2.7 2.7 4.1 4.1 3.4 3.4 3.2 3.2 4.0 4.0 3.8 3.8 3.7 3.7 3.7 3.7 4.1 4.1 3.5 3.5 3.4 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.9 3.9 3.7 3.7 3.3 3.3 3.6 3.6 3.7 3.7 4.2 4.2 3.5 3.5 3.5 3.5 3.6 3.6 3.8 3.8 2.9 2.9 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.8 3.8 3.2 3.2 3.8 3.8 3.4 3.4 iSE VOLUMES (mL) Day 49 Day 50 3.5 3.5 3.3 3.3 3.1 3.1 3.4 3.4 3.6 3.6 3.8 3.8 3.7 3.7 3.8 3.8 3.5 3.5 4.0 4.0 3.2 3.2 3.8 3.8 2.7 2.7 4.3 4.3 3.4 3.4 3.2 3.2 4.1 4.1 4.0 4.0 3.7 3.7 3.8 3.8 4.2 4.2 3.4 3.4 3.5 3.5 3.4 3.4 3.6 3.6 3.6 3.6 3.9 3.9 3.7 3.7 3.4 3.4 3.7 3.7 3.8 3.8 4.4 4.4 3.6 3.6 3.5 3.5 3.6 3.6 3.9 3.9 3.3 3.3 3.6 3.6 3.5 3.5 3.6 3.6 3.4 3.4 3.9 3.9 3.3 3.3 3.9 3.9 3.6 3.6 Day 51 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 Day 52 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 i. ' DuPont-5386 Day 53 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 527 Company Sanitized. Does not contain TSCA CtH H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3 .B 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 Day 56 INDIVIDUAL DC Day 57 3.6 3.6 3.4 3.4 3.2 3.2 3.4 3.4 3.7 3.7 3.1 3.1 3.9 3.9 3.8 3 . B 3.5 3.5 4.1 4.1 3.2 3.2 3.9 3.9 2.8 2.8 4.3 4.3 2.9 2.9 2.9 2.9 4.1 4.1 4.1 4.1 3.8 3.8 3.9 3.9 3.7 3.7 3.5 3.5 3.5 3.5 3.6 3.6 3.7 3.7 3.7 3.7 4.0 4.0 3.8 3.8 3.5 3.5 3.7 3.7 3.8 3.8 4.4 4.4 3.6 3.6 3.6 3.6 3.6 3.6 4.0 4.0 3.4 3.4 3.7 3.7 3.5 3.5 3.8 3.8 3.4 3.4 3.9 3.9 3.4 3.4 3.9 3.9 3.7 _ iSE VOLUMES (mL) Day 58 Day 59 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 Day 60 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 Day 61 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 DuPont-5386 Day 62 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3 .8 3.4 3.9 3.4 3.9 3.7 528 Com pany SwiWtwl. P oes not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 64 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 INDIVIDUAL DC 65 Day 66 3.7 3.7 3.6 3.6 3.3 3.3 3.6 3.6 3.7 3.7 3.5 3.5 4.0 4.0 4.0 4.0 3.5 3.5 4.3 4.3 3.2 3.2 3.9 3.9 2.8 2.8 4.4 4.4 2.9 2.9 3.0 3.0 4.1 4.1 4.2 4.2 3.9 3.9 3.6 3.6 4.0 4.0 3.2 3.2 3.4 3.4 3.3 3.3 3.7 3.7 3.8 3.8 3.8 3.8 3.7 3.7 3.6 3.6 3.8 3.8 3.9 3.9 4.3 4.3 3.4 3.4 3.6 3.6 3.7 3.7 4.0 4.0 3.6 3.6 3.8 3.8 3.3 3.3 3.6 3.6 3.3 3.3 4.0 4.0 3.2 3.2 3.7 3.7 3.8 3.8 ISE VOLUMES (mL) 67 Day 68 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3 .8 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3 .4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 i DuPont-5386 Day 69 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.B 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4,0 3.2 3.7 3.8 Day 70 Day 71 3.8 3.8 2.8 2.8 3.3 3.3 3.7 3.7 3.2 3.2 3.6 3.6 4.0 4.0 4.0 4.0 3.7 3.7 4.3 4.3 3.0 3.0 3.9 3.9 2.8 2.8 4.5 4.5 2.5 2.5 3.2 3.2 3.4 3.4 4.3 4.3 b 3.4 3.4 3.6 3.6 3 . 7 AK T E S T DAY 70 3.0 3.0 3.3 3.3 3.6 3.6 3.6 3.6 3.8 3.8 3.9 3.9 3.9 3.9 3.6 3.6 3.8 3.8 4.0 4.0 3.7 3.7 2.8 2.8 2.9 2.9 3.8 3.8 3.2 3.2 3.6 3.6 3.8 3.8 3.3 3.3 3.8 3.8 3.5 3.5 4.0 4.0 3.2 3.2 3.3 3.3 3.8 3.8 529 Com pany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Day 72 Day 73 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2.8 4.5 2.5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3.8 3.9 3.9 3.6 3.8 4.0 3.7 2.8 2.9 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2.8 4.5 2.5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3.8 3.9 3.9 3.6 3.8 4.0 3.7 2.8 2.9 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 Day 74 INDIVIDUAL DOSE VOLUMES (mL) Day 75 Day 76 77 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2.8 4.5 2.5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3.8 3.9 3.9 3.6 3.8 4.0 3.7 2.8 2.9 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2.8 4.5 2.5 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2.8 4.5 2.5 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 Day 78 3. a 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 Day 79 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 DuPont-5386 Day 80 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 .3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 530 Company Sanitized. Does not contain TSCA C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 81 Day 82 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 u> 00 3.8 3.4 3.4 3.5 3.7 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 INDIVIDUAL DOSE VOLUMES (mL) 83 Day 84 Day 85 86 3 . 8 3 . 9 3 . 9 3.9 3 . 4 3 . 8 3 . 8 3.8 3 . 4 3 . 4 3 . 4 3.4 3 . 5 3 . 7 3 . 7 3.7 3 . 7 3 . 9 3 . 9 3.9 3 .8 4 . 0 4 .0 4.0 3 . 7 4 . 0 4 . 0 4.0 4 . 1 4 . 2 4 .2 4.2 3 .4 3 . 7 3 . 7 3.7 4 . 4 4 . 4 4 . 4 4,4 3 . 3 3 . 3 3 . 3 3.3 4 . 0 4 . 1 4 . 1 4.1 2 . 6 2 . 9 2 . 9 2.9 4 . 5 4 . 7 4 . 7 4.7 3 . 2 3 . 2 3 . 2 3.2 3 .8 4 . 0 4 .0 4.0 3 . 9 4 . 2 4 . 2 4.2 3 . 1 3 . 6 3 . 6 3.6 3 . 8 3 . 9 3 . 9 3.9 3 . 4 3 . 5 3 . 5 3.5 3 . 6 3 . 9 3 . 9 3.9 2 . 9 3 . 6 3 . 6 3.6 3 .9 4 . 1 4 . 1 4.1 3 . 0 3 . 4 3 . 4 3.4 3 . 8 3 . 8 3 . 8 3.8 Day 87 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 4.0 4.2 3.6 3.9 3.5 3.9 3.6 4.1 3.4 3.8 Day 88 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.* 3.3 4.1 2.9 4.7 3.2 4.0 4.2 3.6 3.9 3.5 3.9 3.6 4.1 3.4 3.6 DuPont-5386 Day 89 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 4.0 4.2 3.6 3.9 3.5 3.9 3.6 4.1 3.4 3.8 531 Sanitized. Does not contain TOGACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 90 Male, VII - 250 m g/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 4.0 4.0 3.5 3.8 4.0 4.2 4.1 4.3 3.8 4.5 INDIVIDUAL DOSE VOLUMES (mL) DuPont-5386 532 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Female, II - 0 mg/kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 1.7 1.7 1.8 1.8 1.6 1.6 1.8 1.8 1.9 1.9 2.2 2.2 1.7 1.7 1.8 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.7 1.7 2.1 2.1 1.8 1.8 1.9 1.9 1.9 1.9 1.7 1.7 2.1 2.1 1.9 1.9 2.0 2.0 2.0 2.0 1.9 1.9 2.0 '2.0 1.9 1.9 1.8 1.8 2.1 2.1 2.1 2.1 2.1 2.1 1.8 1.0 1.9 1.9 2.2 2.2 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 2.1 2.1 2.0 2.0 2.1 2.1 1.8 1.8 2.1 2.1 2.0 2.0 1.7 1.7 2.0 2.0 1.9 1.9 2.0 2.0 Day 2 1.7 1,8 1.6 1.8 1.9 2.2 1.7 1.8 1.8 1.6 1.8 1.7 2.1 1.8 1.9 1.9 1,7 2.1 1.9 2.0 2.0 1.9 2.0 1.9 1.8 2.1 2.1 2.1 1.8 1.9 2.2 1.9 1.9 1.8 1.8 2.1 2.0 2.1 1.8 2.1 2.0 1.7 2.0 1.9 2.0 Day 3 1.7 1.8 1.6 1.8 1.9 2.2 1.7 1.0 1.8 1.6 1.8 1.7 2.1 1.8 1.9 1.9 1.7 2.1 1.9 2.0 2.0 1.9 2.0 1.9 1.8 2.1 2.1 2.1 1.8 1.9 2.2 1.9 1.9 1.8 1.8 2.1 2.0 2.1 1.8 2.1 2.0 1.7 2.0 1.9 2.0 INDIVIDUAL DOSE VOLUME Day 4 Day 5 Day 6 1.7 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.6 1.8 1.8 1.8 1.9 1.9 1.9 2.2 2.2 2.2 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.7 2.1 2.1 2.1 l.B 1.8 1.8 1.9 1.9 1.9 1.9 1.9 1.9 1.7 1.7 1.7 2.1 2.1 2.1 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.9 1.9 2.0 2.0 2.0 1.9 1.9 1.9 1.8 1.8 1.8 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 1.8 1.8 1.8 1.9 1.9 1.9 2.2 2.2 2.2 1.9 1.9 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 2.1 2.0 2.0 2.0 2.1 2.1 2.1 1.8 1.8 1.8 2.1 2.1 2.1 2.0 2.0 2.0 1.7 1.7 1.7 2.0 2.0 2.0 1.9 1.9 1.9 2.0 2.0 2.0 533 S (mL) Day 7 Day 8 Day 9 DuPont-5386 Day 10 Day 11 2.0 2.1 1.9 1.9 2.1 2.4 1.9 2.0 2.1 1.7 1.9 12 .. 29 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 2.3 2.0 2.3 2.4 2.5 1.8 2.1 2.4 2.3 2.2 2.0 2.2 2.4 2.3 2.3 2.1 2.4 2.2 1.9 2.2 2.1 2.2 2.0 2.1 1.9 1.9 2.1 2.4 21 .. 09 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 22 .. 30 2.3 2.4 2.5 1.8 2.1 2.4 2.3 2.2 2.0 2.2 2.4 2.3 2.3 2.1 22 .. 42 1.9 2.2 22.. 21 2.0 2.1 1.9 1.9 2.1 2.4 1.9 2.0 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 2.3 2.0 2.3 2.4 2.5 1.8 2.1 2.4 2.3 2.2 2.0 2.2 2.4 2.3 2.3 2.1 2.4 2.2 1.9 2.2 2.1 2.2 2.0 2.1 1.9 1.9 2.1 2.4 21 .. 09 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 22 .. 30 2.3 2.4 2.5 1.8 2.1 2.4 2.3 22.. 02 2.2 2.4 2.3 2.3 2.1 2.4 2.2 1.9 2.2 2.1 2.2 2.0 2.1 1.9 1.9 2.1 2.4 1.9 2.0 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 2.3 2.0 2.3 2.4 2.5 1.8 2.1 2 .4 2.3 2.2 22 .. 20 2.4 2.3 2.3 2.1 22 .. 42 1.9 2.2 2.1 2.2 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D a y 12 D ay 13 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.0 2.1 1.9 1.9 2.1 2.4 1 .9 2.0 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 2.1 2.3 2.3 2.0 2.3 2.4 2.5 1.8 2.1 2.4 2.3 2.2 2.0 2.2 2.4 2.3 2.3 2.1 2.4 2.2 1.9 2.2 2.1 2.2 2.0 2.1 1 .9 1 .9 2.1 2.4 1.9 2.0 2.1 1.7 1.9 1.9 2.2 1.9 2.2 2.1 1.9 2.3 2.3 2.3 2.3 .2 . 1 2.3 2.3 2.0 2.3 2.4 2.5 1.8 2.1 2.4 2.3 2.2 2.0 2.2 2.4 2.3 2.3 2.1 2.4 2.2 1.9 2.2 2.1 2.2 D a y 14 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2.3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2.2 2.7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 D ay 15 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2.3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2.2 2 .7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 INDIVIDUAL DOSE VOLUME D ay 16 D ay 17 D ay 18 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2.3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2 .1 2.2 2.7 2.4 2.3 2.3 2.6 2 .5 2.1 2.5 2.4 2.4 * 2.1 2.3 2.1 1 .9 2.2 2.7 2.1 2.3 2.4 1.9 2 .2. 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2-2 2.7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2 .3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2.2 2 .7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 534 IS (mL) D ay 19 D ay 20 D ay 21 D ay 22 DuPont-5386 D ay 23 2.1 2.1 2.4 2.4 2.4 2.3 2.3 2.4 2.4 2.4 2.1 2.1 2.2 2.2 2.2 1 . 9 1 . 9 2 . 1 2 . 1 2 .1 2.2 2 .2 2 .6 2.6 2 .6 2.7 2.7 2.7 2.7 2.7 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 1.9 1.9 2.1 2.1 2.1 2.2 2.2 2.3 2.3 2.3 2.0 2.0 2.2 2.2 2.2 2 . 4 2 . 4 2 . 7 2 . 7 2 .7 2.1 2.1 2.2 2.2 2.2 2.4 2.4 2.5 2.5 2.5 2.3 2.3 2.5 2.5 2.5 2.1 2.1 2.3 2.3 2.3 2.5 2 .5 2.6 2.6 2 .6 2.4 2.4 2.5 2.5 2.5 2 . 4 2 . 4 2 . 5 2 . 5 2 .5 2.4 2.4 2.7 2.7 2.7 2.2 2.2 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.6 2.6 2.6 2.2 2.2 2.3 2.3 2.3 2.5 2.5 2.8 2.8 2.8 2 . 6 2 . 6 2 . 9 2 . 9 2 .9 2 . 6 2 . 6 2 . 8 2 . 8 2 .8 2 . 0 2 . 0 2 . 1 2 . 1 2 .1 2.2 2.2 2.4 2 .4 2.4 2.7 2.7 2.9 2.9 2.9 2.4 2.4 2.6 2.6 2.6 2.4 2.4 2.6 2.6 2.6 2.1 2.1 2.3 2.3 2.3 2.2 2.2 2.4 2.4 2.4 2.7 2.7 2.8 2.8 2.8 2.4 2.4 2.7 2.7 2.7 2.3 2.3 2.5 2.5 2.5 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.5 2.5 2.7 2.7 2.7 2.1 2.1 2.2 2.2 2.2 2.5 2.5 2.7 2.7 2.7 2.4 2.4 2.5 2.5 2.5 2.4 2.4 2.6 2.6 2.6 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 24 D ay 25 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.4 2.4 2.2 2.1 2.6 2 .7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2.9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2.7 2.5 2.6 2.7 2.7 2.2 2 .7 2.5 2.6 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 .2 . 3 2.6 2.6 2.3 2 .8 2.9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2 .7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 D ay 26 2.4 2.4 2.2 2 .1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2 .5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2 .9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2 .8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 INDIVIDUAL DOSE VOLUME 27 D ay 28 D ay 29 D ay 30 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2 .6 2.3 2 .8 2 .9 2.8 2.1 2.4 2 .9 2.6 2.6 2.3 2.4 2 .8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 2.4 2 .5 2.3 2 .1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2 .7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2 .7 2.7 3.0 2.8 2.4 2.9 2.7 2.7 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2.7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3.0 2.8 2.4 2.9 2.7 2.7 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2 .7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2 .6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3.0 2.8 2.4 2.9 2.7 2.7 535 S (mL) D ay 31 D ay 32 D ay 33 D ay 34 DuPont-5386 D ay 35 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2.7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3.0 2.8 2.4 2 .9 2.7 2.7 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2.7 2.7 2.7 2.7 2.4 2 .9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3 .0 2 .8 2.4 2.9 2.7 2.7 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2.7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3.0 2.8 2.4 2.9 2.7 2.7 2.4 2.5 2.3 2.1 2.7 2.9 2.4 2.6 2.6 2.2 2.4 2.2 2.8 2.3 2.6 2.6 2.4 2.7 2.7 2.7 2.7 2.4 2.9 2.7 2.4 2.9 3.1 2.9 2.3 2.6 3.0 2.9 2.7 2.4 2.5 3.0 2.8 2.7 2.7 3.0 2.8 2.4 2 .9 2.7 2.7 2.6 2.6 2.4 2.2 2.8 3.1 2.6 2.7 2.8 2.3 2.5 2.4 2.7 2.4 2.8 2.8 2.6 2 .9 2.8 2.9 2.9 2.5 3.0 2.8 2.5 3.2 3.2 3.1 2.3 2.6 3.2 3.0 2.9 2.4 2.5 3.2 2.9 2.8 2.9 3.0 2.9 2.5 3.0 2.9 2.9 Company Sanftfzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 36 Day 37 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.6 2.6 2.4 2.2 2.8 3.1 2.6 2.7 2.8 2 .3 2.5 2.4 2.7 2.4 2 .8 2.8 2.6 2 .9 2 .8 2.9 2.9 2.5 3.0 2.8 2.5 3.2 3.2 3.1 2.3 2.6 3.2 3.0 2.9 2.4 2.5 3.2 2.9 2 .8 2.9 3.0 2.9 2.5 3.0 2.9 2.9 2.6 2.6 2.4 2.2 2.8 3.1 2.6 2 .7 2.8 2.3 2 .5 2.4 2 .7 2.4 2.8 2.8 2.6 2 .9 2.8 2.9 2.9 2 . 5 3.0 2.8 2.5 3.2 3.2 3.1 2.3 2.6 3.2 3.0 2.9 2.4 2.5 3.2 2.9 2.8 2.9 3.0 2 .9 2.5 3.0 2.9 2.9 D ay 38 2.0 1.9 1.8 1 .7 2.1 2.3 2.0 2.0 2.1 1.7 1 .9 1.8 2.1 1 .8 2.1 2 .1 2.0 2 .1 2.1 2.2 2.2 1.9 2.3 2.1 1 .9 2.4 2.4 2.3 1.8 1.9 2.4 2.3 2.2 1.8 1.9 2.4 2.2 2.1 2.2 2.2 2.2 1.9 2.2 2.2 2.1 INDIVIDUAL DOSE VOLUMES (mL) Day 39 D ay 40 D ay 41 D ay 42 2.0 1.9 1.8 1.7 2.1 2.3 2.0 2.0 2.1 1.7 1.9 1.8 2.1 1.8 2.1 2.1 2.0 2 .1 2.1 2.2 2.2 1 .9 2.3 2 .1 1.9 2.4 2.4 2.3 1 .8 1.9 2.4 2.3 2.2 1.8 1.9 2.4 2.2 2.1 2.2 2.2 2.2 1.9 2.2 2.2 2.1 2.0 1.9 1.8 1.7 2.1 2.3 2.0 2.0 2.1 1.7 1.9 1.8 2.1 1.8 2 .1 2 .1 2.0 2.1 2.1 2.2 2.2 1 .9 2.3 2.1 1.9 2.4 2.4 2.3 1.8 1 .9 2.4 2.3 2.2 1.8 1.9 2.4 2.2 2.1 2.2 2.2 2.2 1.9 2.2 2.2 2.1 2.0 1.9 1 .8 1.7 2.1 2.3 b 2.0 2.0 2.1 1.7 1.9 1.8 2.1 1.8 2.1 2.1 2.0 2.1 2.1 2.2 2.2 1.9 2.3 2.1 1 .9 2.4 2 .4 2.3 1.8 1.9 2.4 2.3 2.2 1 .8 1.9 2.4 2.2 2.1 2.2 2.2 2.2 1.9 2.2 2.2 2.1 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 D ay 43 D ay 44 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2 .0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2 .3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1 .8 2 .0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 DuPont-5386 D ay 45 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 ' 1.8 1.9 1.8 2.2 1.8 2 .0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 46 D ay 47 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643456 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 Day 4 8 INDIVIDUAL DOSE VOLUMES (mL) Day 49 D ay 50 D a y 51 D ay 52 2.0 2.0 1.8 1.7 2.2 2.3 2 .0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2 .1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1 .9 2.0 2.6 2.2 2.1 2.2 2.3 2 .3 2.0 2.3 2.2 2.2 2.0 2.1 1 .9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2 .5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2 .3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2 .3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 D ay 53 D ay 54 2.0 2 .1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2 .1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2 .7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1 .9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 DuPont-5386 D ay 55 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2.1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 537 C mpany Santt!zed- Doe* not contabi TSCA CBI O H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 56 D ay 57 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2 .0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2 .1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1 .9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2 .1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 INDIVIDUAL DOSE VOLUMES (m L ) 58 D a y 59 D ay 60 D ay 61 D a y 62 2.0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2 .1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2 .5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2 .1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1 .9 1.9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2 .0 2.0 2.1 2.3 1.9 2.1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2.1 2.6 2.7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2 .4 D ay 63 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 D ay 64 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2 .1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 DuPont-5386 D ay 65 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2 .3 2.2 2.2 2.5 2.2 2 .1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 538 Company Sanitized. Does not contain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 66 D ay 67 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2 .1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2 .0 2.0 2.1 2.3 1.9 2.2 2.2 2 .0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2 .1 2.7 2 .7 2.6 1.9 2 .1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 2.1 2.2 2.0 2 .0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2 .3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 D ay 68 2 .1 2.2 2 .0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 INDIVIDUAL DOSE VOLUMES (mL) Day 69 D ay 70 D ay 71 D ay 72 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2,3 2.0 2.0 2.1 2.3 1 .9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2 .1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 2 .1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2.1 2.7 2.7 2 .7 2 .0 2 .1 2.6 2.5 2.4 2.0 2.1 2.8 2.4 2.3 2.5 2.8 2.5 2.1 2.5 2.5 2.5 2 .1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2.1 2.7 2.7 2.7 2.0 2.1 2.6 2.5 2.4 2.0 2.1 2.8 2.4 2.3 2.5 2.8 2.5 2 .1 2 .5 2.5 2.5 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1 .9 2.2 2 .3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2.1 2.7 2.7 2.7 2.0 2 .1 2.6 2.5 2.4 2.0 2.1 2.8 2.4 2.3 2.5 2.8 2.5 2.1 2.5 2.5 2.5 D ay 73 2 .1 2.3 2 .1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2.1 2.7 2.7 2.7 2.0 2.1 2.6 2.5 2.4 2.0 2.1 2.8 2.4 2.3 2.5 2.8 2.5 2.1 2.5 2.5 2.5 D ay 74 2.1 2.3 2 .1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2 .1 2.7 2.7 2.7 2.0 2 .1 2.6 2.5 2.4 2.0 2.1 2.8 2.4 2.3 2.5 2.8 2.5 2.1 2.5 2.5 2.5 DuPont-5386 D ay 75 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.8 2.4 2.3 2.5 2.8 2.5 2.1 2 .5 2.5 2 .5 539 Company Sanitized. Does not contain T3CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 76 D ay 77 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 64337B 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1 .9 2.2 2.8 2.4 2.3 2.5 2.8 2 .5 2.1 2.5 2.5 2.5 2 .1 2 .3 2 .0 2 .0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 2.9 2.5 2.1 2.5 2.5 2.6 D ay 78 2.1 2.3 2 .0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 2.9 2.5 2.5 2.6 INDIVIDUAL DOSE VOLUMES (mL) Day 79 D ay 80 D ay 81 D ay 82 2.1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2 .3 2.1 2 .0 2.2 2.4 2.0 2.3 2.1 2.3 2.0 2 .0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2 .1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2.1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2 .9 2.9 2.9 2.9 2.5 2.5 2.5 2.5 2.1 2.1 2.1 2.1 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 DuPont-5386 83 D ay 84 D a y 85 2 .1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2.2 2.4 2.0 1.9 2 .8 2.6 2.3 2.3 2.4 2.1 2.1 2.2 2.4 2.0 2.3 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2.1 2.1 2.2 2.4 2.0 2.3 2.7 2.7 2.7 2.4 2.4 2.4 2.3 2.3 2.3 2.6 2.6 2.9 3.0 3.0 2.5 2.5 2.5 2.2 2.2 2 . 5 2 .5 2.5 2.5 2.5 2.6 2.5 2.5 540 SmiHzed. Does no! contain TSCA CM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproduction Evaluations D ay 86 D a y 87 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2 .1 2.1 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 3.0 2 .5 2.2 2.5 2.5 2.5 2.2 2.4 2.0 1 .9 2 .8 2.6 2.3 2.3 2.4 2.1 2 .1 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 3.0 2.5 2.2 2.5 2.5 2.5 D ay 88 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2.1 2 .1 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 3.0 2.5 2.2 2.5 2.5 2.5 INDIVIDUAL DOSE VOLUMES (mL) D ay 89 D ay 90 D ay 91 D a y 92 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2.1 2 .1 2.2 2.4 2.0 2.3 2.2 2.4 2.0 1 .9 2.8 2.6 2.3 2.3 2.4 2.1 2.2 2.5 2.1 1.9 3.0 2.6 2.3 2.4 2.3 2.2 2.2 2.5 2.1 1.9 3.0 2.6 2 .3 2.4 2.3 2.2 2.7 2.4 2.3 2.6 3.0 2.5 2.2 2.5 2 .5 2.5 DuPont-5386 541 Company S a n d e d . Does nof contain TSCA CBT H-245I6: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Day 2 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 1.7 2.1 1 .7 1.9 1.8 1.7 2.1 2.0 2 .1 2 .0 2.0 2.3 1.9 2.2 1.9 1.9 1 .9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 1 .8 2.0 1.7 1 .9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 AK TEST 2.1 1.7 1.9 1.8 1.7 2 .1 2.0 2 .1 2.0 2.0 '2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1 .7 1.9 2.0 DAY 1.8 2.0 1.7 1 .9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 0 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 Day 3 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 IN D I V I D U A L D O S E VOLUME] Day 4 Day 5 Day 6 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 542 S (m L ) Day 7 Day 8 Day 9 DuPont-5386 D ay 10 D ay 11 1.9 1.9 1.9 1.9 1.9 2.3 2.3 2.3 2.3 2.3 1 .9 1.9 1.9 1.9 1.9 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.1 2 . 0 2 . 0 2 . 0 2 . 0 2 .0 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 1.9 1.9 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.9 1.9 1 .9 1.9 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 1.9 1.9 1.9 1.9 1.9 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 12 D ay 13 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.9 2.3 1.9 2.2 2 .1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2.0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2 .3 2.2 2.3 2.2 2.5 2.2 1 .9 2 .1 2.3 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1 .9 2 .0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2 .3 2.2 2.3 2.2 2.5 2.2 1.9 2.1 2.3 D ay 14 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2 .1 2.4 2 .1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2 .3 2 .5 2.4 2.6 2.4 2 .5 2.4 2.0 2.3 2.5 D ay 15 2.0 2 .5 2 .3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2 .1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2 .3 2 .7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2 .3 2.5 INDIVIDUAL DOSE VOLUMES (mL) D ay 16 D ay 17 Day 18d D ay 19 2.0 2 .5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2 .3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2 .1 2.1 2.4 2.1 2.2 2.3 2 .1 2.6 2.4 2.5 2.5 2.4 2 .7 2.3 2 .7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2 .7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 D ay 20 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2 .6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 D ay 21 2.2 2 .8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2 .8 2.7 2.8 2.6 2.1 2.5 2.6 D ay 22 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2 .7 2.6 2.8 2.7 2.8 2.6 2.1 2.5 2.6 DuPont-5386 D ay 23 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2 .8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2 .8 2.7 2.8 2.6 2.1 2.5 2.6 543 "Pany Santflzed Does not contain TSCA CBT H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________________________________________ DuPont-5386 D ay 24 D ay 25 D ay 26 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 64345B 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 2 .1 2.5 2.6 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 2 .1 2.5 2.6 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3 .0 2.6 2.7 2.6 2.8 2.7 2 .8 2 .6 2.1 2.5 2.6 INDIVIDUAL DOSE VOLUMES (mL) n a t / *5Q Ifl 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2 .8 2.6 2 .7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 2.1 2.5 2.6 2.4 2.8 2.7 2.9 2.4 2.7 2.4 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2 .9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2 .3 2.6 2.7 2.4 2.8 2.7 2 .9 2.4 2.7 2.4 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2 .9 2 .8 2.9 2.8 3.1 2 .6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 2.4 2.4 2.8 2.8 2.7 2.7 2.9 2.9 2.4 2.4 2.7 2.7 SB TEST DAY 29 2.6 2.6 2.4 2.4 2.4 2.4 2.3 2.3 2.7 2.3 2.5 2.6 2.5 2 .9 2 .9 2 .8 2.9 2.8 3.1 2.6 3.1 2.6 2 .8 2.7 3 .0 3.0 2 .9 2.8 2.3 2.6 2.7 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2 .3 2.6 2.7 2.4 2.8 2.7 2 .9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2 .9 2 .8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 2.4 2.8 2.7 2.9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 2.4 2.8 2.7 2 .9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 2.5 3.0 2 .8 2 .9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3 .0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 544 Company Sanitized. Does not contain TSCA CB! ) <1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 36 Day 37 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.5 3.0 2.8 2.9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3 .0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 2.5 3.0 2.8 2.9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3.0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 D ay 38 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2.1 1.8 2.0 2.1 INDIVIDUAL DOSE VOLUMES (mL) D ay 39 D ay 40 D ay 41 D ay 42 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2 .1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2 .0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2.1 1.8 2 .0 2.1 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 *2.1 , 1.8 2.0 2.1 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2 .1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2.1 1.8 2.0 2.1 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 D ay 43 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 D ay 44 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 DuPont-5386 D ay 45 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2 .1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 545 Company Sanitized. Does not contain TSCA CBf ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 46 D ay 47 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2 .1 2.0 2.4 2.1 2.2 2.4 2,2 2 .8 2.2 2.5 2 .1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 D ay 48 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 INDIVIDUAL DOSE VOLUMES (mL) Day 4 9 D a y 50 D ay 51 52 2.0 2.3 2.2 2.3 2.1 2.3 2.1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.0 2.3 2.2 2.3 2.1 2.3 2.1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.0 2 .3 2.2 2.3 2 .1 2.3 2.1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.0 2.3 2.2 2.3 2.1 2.3 2 .1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 D ay 53 2.0 2.3 2.2 2.3 2.1 2.3 2.1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 D ay 54 2.0 2.3 2.2 2.3 2.1 2.3 2.1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 DuPont-5386 D ay 55 2.0 2.3 2.2 2 .3 2.1 2.3 2.1 2.0 2.0 2.0 2 .3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 546 Company Sanitized. Does not contain TSCA CBT H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 56 D ay 57 F e m a le / IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.1 2.4 2.4 2.4 1 .8 2.4 2.2 2.1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2 .9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2 .1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2 .0 2.1 2.2 INDIVIDUAL DOSE VOLUMES (mL) 58 D ay 59 D ay 60 D ay 61 62 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 2 .1 2.4 2.4 2.4 1.8 2.4 2.2 2 .1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 2 .1 2.4 2.4 2.4 1.8 2.4 2.2 2 .1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 2 .1 2.4 2.4 2.4 1.8 2 .4 2.2 2.1 2.0 1 .9 2.2 2 .0 2.1 2.2 2.1 2.4 2 .3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 2.0 2.1 2.2 D a y 63 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 D ay 64 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 DuPont-5386 D ay 65 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2 .1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 547 Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 66 D ay 67 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2 .1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 CO to 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 D ay 68 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 INDIVIDUAL DOSE VOLUMES (mL) D ay 69 D ay 70 D ay 71 D ay 72 2.1 2 .1 2.1 2.1 2.5 2.6 2.6 2.6 2.3 2.4 2.4 2.4 2.5 2.6 2.6 2.6 2.2 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.1 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.0 2 .0 2.0 2.0 2.3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.2 2.3 2.3 2.3 2.2 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.5 2.5 2.5 2.5 2.3 2.4 2.4 2.4 2.2 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.3 2.4 2.4 2.4 2.9 3.0 3.0 3.0 2.2 2.3 2.3 2.3 2.7 2 .7 2.7 2.7 2.3 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.7 2.7 2.7 2.7 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.2 2.3 2.3 2.3 2.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 DuPont-5386 D ay 73 D a y 74 D ay 75 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 b 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2.0 2.2 2.3 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 , 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2.0 2.2 2.3 2 .1 2 .e 2 .4 2 .6 2 .3 2 .4 2 .2 2 .2 2 .1 2 .0 2 ..3 2 ..1 2 .3 548 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 76 D ay 77 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.1 2.6 2.4 2 .6 2.3 2.4 2.2 2.2 2.1 2.0 2 .3 2 .1 2.3 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2.1 2.2 D ay 78 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2.1 2.2 INDIVIDUAL DOSE VOLUMES (mL) D ay 79 D ay 80 D ay 81 D ay 82 2.2 2.2 2.2 2.2 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.0 2.0 2.0 2.0 2 .3 2.3 2.3 2.3 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 D ay 83 2.2 2 .7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2.1 2.2 DuPont-5386 D ay 84 D ay 85 2.2 2.7 2.5 2.6 2.2 2.4 2 .3 2.2 2.2 2.0 2.3 2.1 2 .3 2 .2 2 .7 2 2 ..56 2 .2 2 .4 2 .3 2 .2 2 .2 2 .0 2 .3 2 .1 2 .3 549 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 86 D ay 87 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 64343B 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.2 2.7 2.5 2.6 2.2 2.4 2 .3 2.2 2.2 2 .0 2.3 2 .1 2.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2.1 2.3 D ay 88 INDIVIDUAL DOSE VOLUMES (mL) D ay 89 D a y 90 D a y 91 D ay 92 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2 .1 0.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2 .0 2.3 2.1 2.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.2 2.7 2.5 2 .7 2.2 2.4 2.3 2.3 2.2 2.2 2.7 2.5 2.7 2.2 2.4 2.3 2.3 2.2 DuPont-5386 550 Company Sanitized. Does not contain TSCA CBI \) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Day 0 Day 1 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 1.9 1.8 1.7 1.7 1 .9 2.1 2.0 1.6 1.7 1.7 1.8 1 .8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1 .9 1.9 2.0 - 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1 .9 1.9 2.0 2.0 2.0 1.8 1.9 Day 2 1.9 1.8 1.7 1.7 1.9 2.1 2 .0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 Day 3 1.9 1.8 1.7 1.7 1.9 2 .1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1 .9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 INDIVIDUAL DOSE VOLUMES (mL) Day 4 Day 5 Day 6 Day 7 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1 .8 1.6 1.9 1 .8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 Day 8 Day 9 2 .1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2 .1 2.2 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 Day 10 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2.1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 D ay 11 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2.1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2 .1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 551 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL DOSE VOLUMES (mL) D ay 12 D ay 13 D ay 14 D ay 15 D ay 16 D ay 17 D ay 18 D ay 19 D ay 20 Day 21 D ay 22 D ay 23 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2.1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2.1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2.0 2.1 2.1 2.0 2.2 2.2 2.2 2.1 2.2 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2.3 2.3 2.3 2.3 2.5 2.4 2.3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2.3 2.3 2.3 2.3 2.5 2.4 2.3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2.3 2.3 2.3 2.3 2 .5 2.4 2.3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2 .4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2.3 2.3 2.3 n2 .1J 2 .5 2.4 2 .3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2 .J. 2.3 2.1 2.2 2.0 nA 2 .J *2>. 2*5 2.8 2 .4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2 A 23 2.3 2.3 2.3 2.4 2.3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2 .5 2.3 2.2 2.6 2 .3 2.5 2.1 2.3 2.3 2.3 2.3 2.5 2.4 2.3 2.5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2 .4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2.1 2.3 2.3 2.3 2.3 2.5 2.4 2.3 2.5 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2.5 2.6 2.5 2.4 2.6 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2.5 2.6 2.5 2.4 2.6 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2.5 2.6 2.5 2.4 2.6 552 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 D ay 24 D ay 25 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2 .1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2.5 2.6 2.5 2.4 2.6 2.5 2.4 2.3 2.3 2.6 2 .9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2.5 2.6 2.5 2.4 2.6 INDIVIDUAL DOSE VOLUMES (mL) 26 D a y 27 D a y 28 D a y 29 D a y 30 D a y 31 D a y 32 D a y 33 Day 34 Day 35 2 .5 2.4 2 .3 2 .3 2 .6 2 .9 2 .7 2 .1 2.2 2 .3 2 .5 2 .3 2 .4 2.2 2 .7 2 .5 2.4 2 .8 2 .5 2.4 2 .7 2 .3 2 .3 2 .9 2.4 2 .7 2 .2 2 .4 2 .5 2 .4 2 .5 2 .6 2 .5 2 .4 2.6 2.5 2.4 2.3 2.3 2.6 2 .9 2.7 2.1 2.2 2 .3 2.5 2.3 2.4 2.2 2.7 2 .5 2.4 2 .8 2 .5 2.4 2.7 2.3 2 .3 2.9 2.4 2.7 2.2 2.4 2 .5 2.4 2.5 2.6 2.5 2.4 2.6 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2.5 2.0 2.4 2.3 2 .8 2.6 2.6 3.0 2.6 2.6 2 .8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2.8 2.6 2.4 2.8 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2.5 2.0 2.4 2.3 2.8 2.6 2.6 3 .0 2.6 2.6 2.8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2.8 2.6 2.4 2.8 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2 .5 2.0 2.4 2.3 2.8 2.6 2.6 3 .0 2.6 2.6 2.8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2 .8 2.6 2.4 2.8 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2.5 2.0 2.4 2.3 2.8 2.6 2.6 3.0 2.6 2.6 2.8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2.8 2.6 2.4 2.8 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2.5 2.0 2.4 2.3 2.8 2.6 2.6 3.0 2.6 2.6 2.8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2 .8 2.6 2.4 2.8 2.6 2.4 2 .5 2 .5 2 .7 3 .0 2 .8 2 .2 2 .3 2.4 2 .5 2 .0 2 .4 2 .3 2 .8 2 .6 2 .6 3 .0 2 .6 2 .6 2 .8 2 .6 2 .4 3 .1 2 .6 2 .9 2 .5 2 .6 2 .5 2 .6 2 .6 2 .8 2 .6 2 .4 2 .8 2.6 2.4 2.5 2.5 2.7 3.0 2.8 2.2 2.3 2.4 2.5 2.0 2.4 2.3 2.8 2.6 2.6 3.0 2.6 2.6 2.8 2.6 2.4 3.1 2.6 2.9 2.5 2.6 2.5 2.6 2.6 2.8 2.6 2.4 2.8 2.7 2.6 2.6 2.6 2.8 3.2 2.9 2.4 2.4 2.5 2.6 2.0 2.5 2.2 2.8 2.8 2.6 3.1 2.8 2.7 2.9 2.7 2.5 2.8 2.6 3.0 2.5 2.7 2.7 2.7 2.7 2.9 2.8 2.6 2.9 553 Company Sanitized. Does not contain TSCA CBl H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 36 D ay 37 F e m a le , VI - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.7 2.6 2.6 2.6 2.8 3.2 2.9 2.4 2.4 2.5 2.6 2 .0 2.5 2.2 2 .8 2.8 2.6 3.1 2.8 2.7 2.9 2.7 2.5 2.8 2.6 3.0 2.5 2.7 2.7 2.7 2.7 2.9 2.8 2.6 2.9 2.7 2.6 2.6 2.6 2.8 3.2 2.9 2.4 2.4 2.5 2.6 2.0 2.5 2.2 2.8 2.8 2.6 3 .1 2.8 2.7 2.9 ' 2.7 2.5 2.8 2.6 3.0 2.5 2.7 2.7 2.7 2.7 2 .9 2.8 2.6 2.9 D ay 38 2.0 2.0 2.0 2.0 2.1 2.4 2.2 1 .8 1.8 1 .9 1.9 1.5 1.9 1.7 2.1 2.1 2 .0 2 .3 2 .1 2.1 2.2 2 .0 1 .9 2.1 2.0 2.2 1 .9 2 .0 2 .0 2 .0 2 .1 2.2 2 .1 2 .0 2.2 INDIVIDUAL DOSE VOLUMES (mL) D ay 39 D ay 40 D ay 41 D ay 42 2.0 2.0 2.0 2.0 2.1 2.4 2.2 1.8 1.8 1.9 1 .9 1.5 1.9 1.7 2.1 2.1 2.0 2.3 2.1 2.1 2.2 2.0 1 .9 2 .1 2.0 2.2 1.9 2.0 2.0 2.0 2 .1 2.2 2.1 2.0 2.2 2.0 2.0 2.0 2.0 2.1 2.4 2.2 1.8 1.8 1.9 1.9 1.5 1.9 1.7 2 .1 2.1 2 .0 2.3 2.1 2.1 2.2 2.0 1.9 2.1 2.0 2.2 1.9 2.0 2.0 2.0 2.1 2.2 2.1 2.0 2.2 2.0 2.0 2.0 2 .0 2.1 2.4 2.2 1.8 1.8 1.9 1.9 1.5 1.9 1.7 2.1 2.1 2.0 2 .3 2.1 2.1 2.2 2.0 1.9 2.1 2.0 2.2 1.9 2.0 2.0 2.0 2.1 2.2 2.1 2.0 2.2 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2 .1 2.1 2.3 2.2 2.0 2.3 D ay 43 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.0 2.3 D ay 44 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.0 2.3 DuPont-5386 D ay 45 2.1 2 .0 2.0 2 .1 2.1 2.5 2.2 1.9 1.9 2.0 2 .0 1.4 2 .0 1 .9 2 .3 2.2 2.1 2.4 2 .1 2.1 2.2 2 .1 2.0 2 .1 2.0 2.3 2.0 2 .1 2.1 2.1 2 .1 2 .3 2 .2 2 .0 2.3 554 Conpany Sanitized. Does not contain TSCA cg( H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________ INDIVIDUAL DOSE VOLUMES (mL) D ay 46 D ay 47 D ay 48 D ay 49 D ay 50 D ay 51 D ay 52 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2 .1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1 .9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2 .1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.0 2.3 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2 .0 2.0 1.4 2 .0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.0 2.3 2.1 2.0 2 .0 2.1 2 .1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2.2 2.0 2.3 2.1 2 .1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.2 2.3 2.3 2.1 2.3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2.3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2 .3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2 .3 2.3 2.1 2.3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2.3 D a y 53 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2.3 Day 54 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2.3 DuPont-5386 Day 55 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2.3 555 D o e s n o t c o n ta in T S C A C B I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________ _ INDIVIDUAL DOSE VOLUMES (mL) D ay 56 D ay 57 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 6 4 3 3 B1 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2 .1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1 .9 2.2 2.3 2.1 2 .3 2.2 2.3 2.3 2.2 2 .1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2 .3 D ay 58 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 D ay 59 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 D ay 60 2.1 2.2 2.0 22.. 21 2.4 2.3 1.9 1.9 2 .0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2 .1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 D ay 61 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 62 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 D ay 63 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1 .9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 D ay 64 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 DuPont-5386 D ay 65 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 556 Company Sanitized. Does not contain TSCA CBI J H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ . D ay 66 D ay 67 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 2.2 2.2 2 .0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2 .1 1 .8 2 .1 1.9 2 .3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 D ay 68 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 INDIVIDUAL DOSE VOLUMES (mL) D ay 69 D ay 70 D ay 71 D ay 72 2.2 2.2 2 .0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.9 2.2 2.4 2.2 2.3 2.3 2.2 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2 .0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2 .5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2 .4 2.1 2.4 D ay 73 2.2 2.3 2.0 2 .3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 D a y 74 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2 .1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 DuPont-5386 D ay 75 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 557 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction E v a l u a t i o n s ____________ _ D ay 76 D ay 77 D ay 78 INDIVIDUAL DOSE VOLUMES (mL) D ay 79 D ay 80 D ay 81 D ay 82 F em ale, VI 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 - 100 mg/k g /d a y 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.0 1.9 2.1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 b 2.2 1.9 2.1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 D ay 83 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 Day 84 2.2 2.4 2.3 2.3 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 DuPont-5386 Day 85 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 558 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 86 D ay 87 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 D ay 88 INDIVIDUAL DOSE VOLUMES (mL) D ay 89 D a y 90 D ay 91 D ay 92 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2 .0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.2 2.4 2.1 2.3 2.4 2.5 2.4 2.1 2.0 2.1 2.2 2.4 2.1 2.3 2.4 2.5 2.4 2.1 2.0 2.1 DuPont-5386 559 Company Sanitized. Does not contain TSCA CBf ,) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Day 0 Day 1 Day 2 Day 3 INDIVIDUAL DOSE VOLUMES (mL) Day 4 Day 5 Day 6 Day 7 Day 8 Day 9 D ay 10 D ay 11 F e m a le , V III - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2 .0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2 .1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 . 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 - 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2 .1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1-8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1-8 1-9 1.9 2.0 1.7 1.9 1.7 1-9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1-9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1-9 1.8 2.1 1-9 1.8 1.9 I -9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1 .9 2.0 1.7 1 .9 1.7 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1 .9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2 .1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2 .0 2.3 2.0 2.2 2.2 2.3 2 .5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 560 Company Sanitized. Does not contain TSCA C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 D ay 12 D ay 13 D ay 14 D ay 15 INDIVIDUAL DOSE VOLUMES (mL) D ay 16 D ay 17 D ay 18 D ay 19 D ay 20 D ay 21 D ay 22 D ay 23 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1 .9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2 .1 2.1 1.9 2.2 2.1 1 .9 2.5 2.3 2.0 2.5 2 .1 2.2 2.3 - 2.0 2 .3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1 .9 2.2 1.9 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2-9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.4 2.6 22.. 62 2.3 561 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 24 D ay 25 D ay 26 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 6 4 3 4 B1 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2 .9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2 .3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3 .0 2.4 2.5 2.6 - 2.4 2.8 2.4 2.6 2.4 2 .6 2.9 2.9 2 .7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2 .9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 INDIVIDUAL DOSE VOLUMES 27 D ay 28 D ay 29 D ay 30 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2 .9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2 .5 2 .9 2.5 2.7 2.6 2,8 3.1 3.1 2 .8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 ' 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3 .1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.6 3.1 3.1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3 .1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3.1 3.1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 562 i > (m L ) D ay 31 D ay 32 D a y 33 D ay 34 DuPont-5386 D ay 35 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2 .8 2.5 2.9 2.5 2.7 2.6 2.8 3.1 3.1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2 .4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2 .7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 22 .. 76 2.8 3.1 3.1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3.1 3.1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2 .7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 22 ..46 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3.1 3.1 2.8 2.5 2.5 3.0 2 .9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.7 23 .. 28 2.4 2.6 2.5 2.6 2.7 2.9 2 .0 2.5 2.6 2.6 2.4 3.1 2.8 2.5 3.1 2.6 2.8 3.0 2.6 32 .. 06 2.9 2.7 2.9 3.2 3.3 23 .. 06 2.8 3.1 3.0 2.6 2.4 3.1 2.6 2.5 2.5 2.7 2.8 22 .. 48 2.5 Company Sanitized. Does not contain TSCA CM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 36 D ay 37 D ay 38 F e m a le , V III - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.7 3.2 2.8 2.4 2.6 2.5 2.6 2.7 2.9 2.8 2.5 2.6 2.6 2.4 3.1 2.8 2.5 3.1 2.6 2.8 3.0 2.6 3.0 2.6 2 .9 2.7 2.9 3.2 3.3 3.0 2.6 2.8 3.1 3.0 2.6 2.4 3.1 2.6 2.5 2.5 2.7 2.8 2.4 2.8 2.5 2.7 3.2 2.8 2.4 2.6 2.5 2.6 2 .7 2.9 2.8 2.5 2.6 2.6 2.4 3.1 2.8 2.5 3 .1 2.6 2 .8 3.0 2.6 3 .0 2 .6 2.9 2.7 2.9 3.2 3.3 3 .0 2.6 2.8 3.1 3.0 2.6 2.4 23 .. 16 2.5 2.5 2.7 2.8 2.4 2.8 2.5 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2.1 1.9 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 D ay 41 D ay 42 2.0 2.4 2 .1 1.8 1.9 1.9 1.9 2 .0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2.1 1.9 2.0 2.4 2 .1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2.1 1.9 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2.1 1.9 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 Day 43 D ay 44 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2 .1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.2 1 .9 2 .1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 DuPont-5386 D ay 45 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2 .1 2.3 1.9 2.2 2.0 563 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 46 D ay 47 F e m a l e , V I I I - 2 5 0 m g/ k g / d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2 .0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2 .1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2 .0 2.1 2 .3 2.0 2.3 1 .9 2 .3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 INDIVIDUAL DOSE VOLUMES (mL) 48 D ay 4 9 D ay 50 51 D ay 52 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2 .1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2 .1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 D ay 53 D ay 54 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 AK TEST 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.5 2.2 1.9 22 .. 00 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 53 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 12.. 06 1.9 2.2 2.3 1.9 2.3 2.0 DuPont-5386 D ay 55 2.5 2.2 12 .. 90 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 2.2 2.5 2.5 2.3 2.0 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 564 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 56 D ay 57 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2 .5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2 .1 2.3 1.9 2.2 2.0 2.1 2.5 2 .3 1 .9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 D ay 58 2.1 2.5 2 .3 1 .9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2 .1 2 .0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 INDIVIDUAL DOSE VOLUMES (mL) D ay 59 D ay 60 D ay 61 D ay 62 2.1 2.5 2.3 1.9 2.2 12 .. 90 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2 .0 2.4 2 .2 2 .5 2 .5 2.2 2 .0 2 .2 2.4 2 .3 2.1 1 .9 1 .8 1.7 1 .8 1 .9 2 .1 2.3 1 .9 2.2 2.0 2.1 2.5 2.3 1.9 2.2 12 .. 90 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.3 1.9 2.2 21 .. 90 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 22 .. 10 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.3 1.9 2.2 12 .. 90 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 22 ..50 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1 .9 2.2 2.0 D ay 63 2.1 2.3 2.3 1.9 2.1 1.9 22 .. 00 2.4 22.. 01 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 -a 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 D ay 64 2.1 2.3 2.3 1.9 2.1 122 ... 900 2.4 22 .. 10 2.2 2.2 1.8 2.5 22 .. 10 2.4 2.1 2.2 2.3 2.0 x.a 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 DuPont-5386 D ay 65 2.1 2.3 2.3 1.9 2.1 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2 .4 2.1 2.2 22 .. 30 2.0 2.5 1.9 2.5 2 .5 2.1 1.9 2.3 2.4 2.3 2.1 2 .0 2.3 1.9 2.0 1 .6 2 .2 2.0 1 .9 2 .0 2.0 565 Company Sanitized. Does not contain TSCA CBI J. w' H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 66 D ay 67 F e m a le , V III - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 l.B 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1 .9 2.0 2.0 2.1 2.3 2.3 1.9 2.1 1.9 2 .0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2 .5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1 .9 2 .0 2.0 D ay 68 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1 .8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1 .8 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 INDIVIDUAL DOSE VOLUMES (mL) D ay 69 D ay 70 D ay 71 D ay 72 2 .1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 FD TEST 2.0 2.2 2.2 1 .8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 DAY 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 69 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 1 .9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2 .1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 to o 2 .1 2.2 2.3 1.9 2.2 2.0 2 .1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 12 .. 96 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 INDIVIDUAL DOSE VOLUMES (mL) D ay 73 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 D ay 74 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 12 ..96 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 DuPont-5386 D ay 75 2.1 2.2 2 .3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 566 Company Sanitized Does not contain TSGA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 76 D ay 77 D ay 78 D ay 79 D ay 80 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643386 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2 .2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 b 2.2 1.9 2.6 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.0 2.4 2.4 1.9 1.9 2.0 2.0 2.0 2.1 2.2 2.2 2.0 2.1 2.0 1.8 2.2 2.3 2.1 1.9 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 4 DuPont-5386 01 D a y 82 D ay 03 D a y 84 D a y 85 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.5 2.5 2.3 2.3 2.3 2.4 2.4 1.9 1.9 1.9 1.9 1.9 2.1 2.1 2.1 2.2 2.2 2.0 2.0 2 .0 2.1 2.1 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 2.3 2.3 b 2.5 2.5 2.5 2.5 2.5 to to 1.7 1.7 1.7 2.0 2.0 2.2 2.2 2.3 2.3 1.9 1.9 1.9 2.3 2.3 1.8 1.8 1.8 2.0 2.0 2.1 2.1 2.1 2.5 2.5 2.0 2.0 2.0 2.0 2.0 2 .4 2.4 2.4 2.6 2.6 1.9 1.9 1.9 2.1 2.1 2.0 2.0 2.0 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.3 2.3 2.1 2.1 2.1 2.3 2.3 1.8 1.8 1.8 2.0 2.0 2.3 2.3 2.3 2.5 2.5 1.9 1.9 1.9 2.1 2.1 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity D ay 86 D ay 87 F e m a le , V III - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2 .0 2.3 2.3 2.0 2.5 2 .0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 D ay 88 2.2 2.5 2.4 2.5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 D ay 89 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 Li D O S E V O L U M E S (m L ) 90 D ay 91 D ay 92 2.2 2.2 2.2 2.5 2.6 2.6 2.4 2.2 2.2 1 . 9 1 . 9 1 .9 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.0 2.0 2.3 2.3 2.3 2.5 2.6 2.6 DuPont-5386 568 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX C INDIVIDUAL BODY WEIGHTS 569 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES DuPont-5386 Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day of non-fasted body weight data collection for rats designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day of non-fasted body weight data collection for rats designated for the 3-month recovery penod. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extrem is 570 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 M a le , I - 0 mg/k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 278.0 237.5 237.1 262.8 282.1 246.7 235.8 253.6 254.9 254.0 264.6 263.0 244.5 274.2 236.7 246.4 277.8 237.8 207.6 249.3 265.9 243.4 231.5 257.2 253.4 268.6 252.9 244.2 244.9 240.4 251.3 281.7 236.4 245.1 242.2 298.8 243.1 254.1 256.0 227.0 211.2 227.3 220.3 248.7 265.6 Day 7 347.0 296.9 291.5 313.3 345.3 311.5 290.4 323.7 320.6 304.8 321.1 309.7 292.8 336.3 291.4 296.4 341.8 282.6 255.6 300.5 311.9 285.4 279.3 317.0 306.4 335.4 315.7 307.5 295.6 294.8 313.7 352.7 277.9 290.7 300.1 357.6 297.0 311.4 315.6 286.3 261.4 284.3 268.7 291.4 322.1 D ay 14 409.3 347.2 340.0 356.7 409.6 361.6 340.4 383.9 377.6 350.2 377.0 338.8 342.8 383.7 343.2 345.3 391.5 316.6 298.9 347.8 359.0 326.2 336.3 382.3 351.0 393.3 364.9 356.2 350.4 348.8 358.7 422.7 321.0 336.3 346.6 426.4 352.7 372.2 370.4 343.9 303.5 331.6 305.7 334.6 370.7 INDIVIDUAL BODY WEIGHTS (g) D ay 21 D ay 28 D ay 35 451.2 392.9 381.3 409.0 459.2 413.8 362.3 431.3 422.4 392.1 433.9 381.3 396.9 429.6 384.1 382.5 432.3 352.1 330.0 392.6 402.9 359.2 375.5 425.2 392.3 443.0 415.5 401.4 389.9 389.5 396.8 466.9 360.2 367.4 380.9 467.6 404.2 421.4 426.6 389.2 338.4 365.0 334.2 369.7 407.6 497.6 423.9 419.4 447.6 511.4 459.6 383.1 468.9 , 459.8 427.6 468.7 396.6 416.7 464.4 414.4 412.6 473.6 371.3 351.7 427.3 434.6 389.8 407.6 470.9 423.7 482.2 445.2 434.9 417.9 415.4 434.0 502.7 390.9 396.2 407.6 501.7 431.4 452.5 463.9 433.7 370.3 391.1 366.5 397.1 447.8 522.6 455.5 442.7 473.2 535.6 488.3 409.2 492.0 483.3 444.7 504.2 410.7 440.4 489.6 438.3 445.1 501.1 388.2 373.4 451.9 456.5 420.4 442.7 499.1 445.2 524.1 473.0 464.8 435.3 432.1 464.8 542.2 406.0 413.9 426.8 533.1 456.5 493.0 490.3 471.4 391.1 415.9 396.8 433.7 468.8 D ay 42 549.7 483.5 463.6 504.0 571.7 514.2 426.9 520.1 512.9 471.0 524.6 428.1 475.7 522.0 461.4 459.8 535.2 410.2 403.1 480.0 478.7 434.9 472.2 531.5 464.3 548.7 493.2 497.1 455.0 454.4 486.7 565.8 429.5 440.8 460.0 562.4 490.6 517.7 516.2 502.6 418.0 426.5 420.8 459.3 494.1 D ay 49 571.4 501.2 474.5 517.2 584.1 521.8 430.0 515.9 515.0 492.5 545.3 450.8 489.4 542.2 474.4 481.2 555.9 422.3 412.5 493.7 506.2 455.5 489.0 558.3 488.8 574.8 514.0 525.7 478.1 490.8 502.6 600.1 446.6 474.4 479.3 577.3 510.1 543.6 534.6 531.3 436.4 436.8 437.4 481.9 500.7 DuPont-5386 D ay 56 589.6 530.7 492.2 538.3 599.1 549.9 443.8 545.3 539.1 492.2 561.8 452.3 489.5 564.1 491.5 498.7 578.0 437.6 428.9 503.9 529.5 461.7 516.2 583.4 507.0 600.3 539.2 545.5 495.4 528.8 526.7 620.2 463.8 495.9 501.9 592.1 537.3 560.1 569.2 549.6 450.9 416.9 455.2 477.8 521.4 571 Comparii Sanitized. Ones not contain ISCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________ _ INDIVIDUAL BODY WEIGHTS (g) M ale, I 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 D ay 63 D ay 70 0 mg/k g /d a y 607.0 554.5 496.9 546.8 622.4 565.9 461.8 568.6 556.6 512.5 558.0 476.2 489.4 582.8 502.5 508.0 597.3 452.8 442.9 525.7 548.2 480.5 536.5 606.7 518.8 619.7 553.9 571.0 514.1 551.5 539.4 646.7 479.4 515.0 523.1 609.6 545.9 573.9 586.1 568.3 466.6 401.9 471.1 495.0 542.5 621.5 570.0 508.2 563.6 632.0 584.2 474.4 583.2 566.5 528.8 583.0 490.3 501.0 600.6 508.3 509.9 620.1 463.8 451.8 . 533.9 558.2 506.4 557.2 628.5 533.2 643.8 568.9 589.1 524.1 568.0 564.1 676.8 490.4 530.2 540.0 634.0 570.3 592.2 607.0 579.8 480.7 416.8 481.9 504.0 557.6 D ay 74 603.0 510.3 512.4 629.2 469.0 458.8 534.3 568.8 504.9 563.1 624.9 531.3 644.0 573.1 586.3 531.5 593.7 562.4 682.3 478.3 D ay 77 625.0 582.2 516.7 575.1 640.7 596.8 475.8 600.7 582.7 532.8 575.4 505.9 511.4 D ay 84 637.6 594.8 522.5 584.9 657.5 607.1 485.5 613.5 600.6 551.0 589.5 524.7 511.0 505.6 544.4 545.0 641.7 579.1 600.4 620.8 594.0 496.4 378.9 , 495.6 564.4 507.0 550.0 559.9 643.8 599.8 598.8 629.3 607.2 504.3 402.4 515.2 590.1 D a y 90 640.6 601.4 524.1 593.0 665.2 602.7 492.0 628.9 610.2 546.8 573.8 530.6 '5 2 2 . 9 510.5 557.8 572.6 661.1 605.5 608.8 634.6 616.0 508.2 413.3 522.0 595.4 D a y 98 560.0 609.2 547.9 523.9 525.6 577.0 577.3 685.8 637.0 632.1 649.7 640.5 522.5 448.1 536.6 D ay 105 576.6 631.3 533.8 528.2 526.7 594.0 591.4 696.6 645.3 654.2 663.2 657.4 532.4 417.3 544.3 DuPont-5386 D ay 112 587.3 648.2 546.4 533.8 533.0 602.7 618.6 700.1 654.4 664.3 673.9 667.9 544.0 448.3 554.5 572 Company Sanitized. Does not contain TSC C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) M ale, I 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 D ay 119 D ay 126 0 mg/k g /d a y 596.0 601.4 547.3 533.8 578.7 622.5 548.2 538.2 536.4 609.3 '6 2 1 . 1 702.0 661.4 678.7 673.0 671.7 539.2 434.2 555.3 549.0 D ay 133 600.9 636.3 556.5 548.9 569.0 Day 140 600.0 657.5 578.8 553.5 573.0 Day 147 610.7 672.6 593.0 569.2 546.0 D ay 154 616.7 678.3 601.7 579.6 558.4 D ay 161 620.1 693.2 606.0 579.4 573.3 D ay 168 618.8 697.8 621.4 574.1 583.2 DuPont-5386 D ay 175 ' 632.6 720.7 644.4 585.5 594.1 573 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL. BODY WEIGHTS (g) D ay 181 M a le , X - 0 mg/k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 606.2 687.8 617.5 576.9 557.8 DuPont-5386 574 CwnPany Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 0 Day 7 Male, I I I - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 239.1 214.9 227.0 246.5 276.0 259.3 273.4 254.7 240.6 261.6 229.4 259.8 216.0 272.6 245.5 205.8 263.6 261.9 258.0 192.6 251.8 261.5 261.6 231.5 242.3 242.7 273.5 256.8 241.7 252.6 255.0 241.1 262.6 269.4 228.7 302.6 272.0 277.8 300.7 346.4 326.3 332.3 302.4 302.8 313.9 281.6 316.0 259.7 319.4 299.3 255.4 331.6 310.9 322.2 243.1 309.3 325.0 320.0 278.3 292.7 305.5 340.7 318.7 297.3 315.8 312.5 287.6 322.4 327.0 282.5 Day 14 350.3 323.6 325.4 345.8 407.7 386.4 390.6 359.8 362.0 370.9 327.0 364.2 301.6 368.2 352.5 302.0 396.0 350.4 374.9 294.6 365.3 374.6 384.2 337.7 347.4 357.8 402.4 379.9 340.9 377.2 355.7 329.5 368.7 383.1 323.1 Day 21 384.9 357.9 354.9 386.2 450.9 424.1 429.0 377.9 395.4 410.4 356.7 413.5 331.0 401.3 391.4 337.8 438.5 380.0 412.6 329.2 415.2 415.9 421.9 372.1 375.3 402.5 447.9 418.5 369.5 420.1 391.5 358.1 404.3 416.9 356.1 Day 28 423.0 397.1 394.8 424.0 493.7 464.8 465.1 411.6 437.0 443.9 384.8 449.6 365.6 421.8 422.9 369.6 479.3 410.3 449.1 366.6 455.3 460.9 449.8 411.4 416.0 439.7 489.6 459.9 384.5 451.4 418.2 381.9 444.8 456.9 388.9 Day 35 470.2 433.2 412.3 457.9 540.2 498.7 504.4 433.6 478.1 462.1 411.0 475.5 388.1 456.8 461.6 397.0 505.2 433.9 478.6 385.9 487.5 487.4 487.0 443.3 453.5 474.8 522.3 490.4 396.2 487.2 440.8 409.5 480.5 489.3 416.2 Day 42 477.0 462.5 434.7 483.0 560.1 520.4 527.8 446.3 509.5 479.6 428.5 494.6 407.9 468.8 479.7 412.1 522.5 444.8 498.5 409.2 516.2 505.8 503.9 457.3 460.1 492.0 536.6 513.4 413.5 500.3 462.4 422.4 505.7 511.2 430.1 Day 49 490.5 472.6 444.7 489.0 570.3 529.1 536.6 445.4 518.4 480.8 446.9 502.0 407.3 487.3 499.0 422.8 547.8 461.7 513.0 424.6 535.8 510.3 524.0 486.6 470.1 513.4 563.7 531.7 420.6 508.6 475.0 428.4 530.2 532.8 456.4 DuPont-5386 Day 56 51.6 502.0 459.8 502.5 601.8 553.1 564.2 457.0 534.6 497.9 444.1 522.3 420.1 496.7 522 4 436.0 582.7 473.4 523.3 438.4 553.3 531.7 546.0 506.9 492.3 532.3 582.2 551.9 436.4 520.8 488.9 392.3 547.5 549.3 470.9 575 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 63 D ay 70 M a le , XXI - 25 m g/k g / d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 524.4 513.5 487.6 520.8 625.8 564.5 589.3 468.4 554.5 495.5 448.4 535.0 426.4 512.2 540.9 448.0 602.5 489.3 546.0 456.7 582.8 548.6 569.2 526.3 511.4 549.2 589.5 568.2 433.2 537.4 502.2 440.6 565.1 572.6 479.7 528.6 529.0 504.8 534.8 646.0 588.3 603.8 482.3 553.3 514.6 459.8 554.8 438.1 530.6 553.4 466.8 614.3 495.6 564.5 474.3 600.0 557.6 591.6 552.5 525.4 562.8 605.3 591.3 441.2 553.7 516.6 460.8 576.7 586.0 493.3 D ay 74 464.4 627.9 498.8 562.9 469.4 604.5 574.2 594.0 559.7 536.0 566.0 624.1 593.3 461.8 555.7 523.6 480.3 585.6 587.9 495.4 D ay 77 544.9 544.5 520.7 537.5 663.3 600.9 622.6 488.9 557.5 525.3 466.6 553.1 444.8 537.2 547.1 ' D a y 84 540.5 561.0 538.4 536.4 685.3 625.9 635.0 499.6 576.5 541.1 471.6 565.6 461.3 543.1 553.5 D ay 90 514.0 573.3 549.4 541.3 699.3 630.5 651.5 507.7 573.7 543.5 483.2 567.1 464.0 549.6 562.8 D ay 98 489.9 581.8 482.5 564.1 579.5 D ay 105 500.1 597.1 485.5 578.7 587.6 DuPont-5386 D ay 112 508.4 580.5 490.4 597.1 607.7 576 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __________________ _______________________________________ DuPont-5386 INDIVIDUAL BODY WEIGHTS (g) D ay 119 Day 126 M a le , I I I - 25 mg/k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 509.3 565.5 471.9 609.8 606.0 509.9 572.8 479.5 590.0 574.3 D ay 133 521.6 595.9 503.7 581.0 603.1 D ay 140 518.4 605.8 503.3 604.0 617.6 D ay 147 525.8 623.0 514.4 617.7 628.8 D ay 154 532.0 620.3 511.9 630.9 637.5 D ay 161 534.7 626.3 517.1 638.6 644.0 D ay 168 541.9 635.2 529.6 653.5 650.3 D ay 175 550.2 640.2 531.8 672.8 653.7 577 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 181 M a le , I I I - 25 mg/k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 523.6 618.7 514.8 644.7 620.2 DuPont-5386 578 Company Does not contain TSCA CBS H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL.BODY WEIGHTS (g) Day 0 Day 7 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 229.7 230.7 236.3 260.0 280.3 260.0 263.1 271.8 236.3 253.3 231.9 267.5 210.0 280.8 239.5 206.6 248.0 275.5 244.2 241.3 248.4 271.2 249.9 231.1 255.1 244.3 256.6 241.6 257.0 262.7 250.5 243.9 266.4 245.0 273.7 275.3 288.5 297.5 321.5 353.1 321.8 328.2 323.6 302.8 302.9 277.3 306.7 252.5 333.0 286.7 266.7 310.5 327.6 303.7 311.3 310.4 337.7 303.2 276.2 311.6 307.8 314.2 295.0 307.2 330.3 325.4 297.9 330.2 302.6 333.5 D ay 14 311.4 347.9 355.8 373.2 413.5 370.2 371.5 365.2 347.1 341.1 326.1 356.6 286.5 377.1 324.4 315.4 372.2 373.7 347.0 373.9 370.9 398.3 356.6 313.6 361.5 361.8 372.5 347.0 349.9 380.1 382.1 340.4 381.4 347.3 384.1 Day 2 1 , D ay 28 352.4 386.2 385.5 428.9 449.9 423.3 410.1 407.2 387.3 374.5 367.6 394.2 327.5 409.5 366.0 356.1 421.5 420.0 383.5 422.1 418.1 450.8 392.8 348.4 403.0 402.1 420.5 387.2 396.5 411.4 426.5 387.0 428.0 390.3 422.4 . , 385.1 420.0 418.7 462.6 477.0 453.1 431.8 447.9 408.9 404.5 400.8 431.5 361.4 437.5 384.6 394.4 463.8 , 452.0 403.6 466.4 451.2 488.1 426.7 . 378.3 439.3 442.9 460.7 421.9 411.0 448.5 471.1 415.0 467.0 411.9 450.4 D ay 35 395.5 447.4 444.2 494.4 496.7 480.4 452.1 469.6 436.2 420.0 420.2 466.1 389.5 462.1 397.7 420.1 496.5 479.7 418.1 482.0 483.7 522.6 447.3 391.4 466.3 466.1 480.4 453.2 434.9 469.4 499.8 437.8 492.5 433.8 481.2 D ay 42 408.9 469.2 466.3 512.8 526.4 503.8 477.8 488.0 451.8 436.4 439.8 480.7 411.9 490.6 4 1 8 .0 ' 442.7 513.6 495.2 433.0 488.3 501.5 545.1 469.6 403.4 484.5 496.6 513.1 478.9 460.5 500.7 519.7 459.2 518.3 458.8 502.1 D ay 49 422.1 481.1 475.2 523.8 480.4 509.0 492.6 500.2 459.5 446.2 449.4 498.9 435.9 518.5 443.3 466.4 528.5 512.3 439.0 507.9 533.6 565.4 490.9 418.6 504.1 511.8 539.6 503.9 488.2 531.6 546.4 480.6 549.9 481.7 521.2 DuPont-5386 D ay 56 440.1 496.8 481.7 538.3 504.2 532.2 505.1 521.0 474.9 450.1 447.0 515.8 447.5 533.3 440.1 485.4 548.9 527.2 463.6 519.5 535.7 578.5 494.6 437.0 521.7 529.4 557.6 522.3 511.5 548.9 566.2 494.2 574.7 500.5 538.7 579 Company Sanitized, Ones not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 63 D ay 70 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 458.6 520.0 494.5 549.9 527.4 526.3 516.8 541.3 485.0 467.1 448.5 532.6 471.8 541.8 460.9 502.2 567.2 544.7 486.8 529.0 545.3 597.9 520.1 459.4 540.3 546.4 583.6 555.1 528.7 561.0 581.6 509.0 598.7 519.4 567.0 472.1 532.4 508.7 563.5 545.3 454.6 531.0 560.5 496.1 471.5 469.4 536.5 484.2 570.7 473.7 511.2 582.9 573.3 502.0 544.7 568.2 607.6 514.6 469.9 559.1 564.3 601.7 575.1 547.4 577.4 602.5 516.2 615.1 529.6 562.5 D a y 74 514.2 588.1 573.8 513.4 551.5 570.1 605.8 508.5 468.8 561.0 570.6 612.3 576.5 547.3 589.1 602.9 514.9 610.9 529.4 561.8 D ay 77 D a y 84 D ay 90 470.0 543.5 511.3 570.8 555.9 397.4 538.2 562.2 501.5 480.8 475.8 544.8 490.8 590.3 472.9 485.1 548.3 519.3 575.6 562.6 AK TE ST DAY 77 476.3 542.8 513.3 491.0 486.1 534.0 501.8 599.8 489.0 492.6 554.5 526.4 593.3 572.4 529.3 541.2 520.6 490.7 488.4 532.7 498.4 599.1 496.3 D a y 98 506.9 545.3 496.8 588.8 501.8 D ay 105 514.8 427.7 509.2 613.1 502.8 DuPont-5386 D ay 112 515.4 463.3 513.5 638.1 496.8 580 Company Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 119 D ay 126 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 497.5 515.1 503.2 636.4 506.4 517.7 539.7 461.5 631.3 505.3 D ay 133 510.3 555.0 504.4 635.1 520.8 D ay 140 523.2 574.0 527.3 657.0 521.1 D ay 147 535.0 587.4 544.4 676.0 532.0 D ay 154 548.3 609.0 556.8 688.4 533.0 D ay 161 555.9 611.1 557.1 706.6 542.4 D ay 168 569.3 620.0 563.7 738.4 548.5 DuPont-5386 D ay 175 574.5 626.5 579.6 757.2 555.4 581 Company Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________________________________________________ DuPont-5386 INDIVIDUAL BODY WEIGHTS (g) D ay 181 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 555.3 608.8 558.5 729.9 534.3 582 Company Sanitized. Poes not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY Day 0 Day 7 M a le , V II - 250 mg/k g /d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 238.2 224.4 230.1 236.0 267.2 265.5 251.8 266.4 242.1 275.9 238.2 261.9 226.2 286.4 250.2 211.8 263.8 264.8 249.1 255.7 285.9 256.2 249.3 235.1 239.6 237.1 261.3 260.1 244.4 273.4 252.4 277.8 246.7 250.3 263.9 274.6 234.0 236.7 249.0 246.7 239.2 248.3 234.2 281.8 239.4 296.9 287.0 281.8 289.8 326.9 335.0 325.1 334.3 294.4 348.3 294.3 313.8 274.0 353.0 303.9 268.2 334.8 337.4 307.1 319.2 367.2 310.3 307.8 293.7 300.4 298.9 322.5 321.7 297.8 335.9 315.5 349.2 303.2 302.3 326.3 340.6 301.5 296.6 311.4 312.8 299.5 312.4 284.8 343.2 299.2 D ay 14 336.6 332.4 320.5 330.8 372.9 383.2 379.6 379.8 344.4 394.7 342.9 356.5 306.3 412.6 340.2 307.3 394.0 388.3 355.1 362.8 419.8 350.0 350.4 337.6 350.8 348.7 374.0 366.1 331.5 381.9 366.7 410.4 353.5 350.8 371.9 391.8 352.8 350.5 360.1 362.7 354.3 367.0 326.3 384.9 342.7 D ay 21 382.6 372.1 352.4 372.3 417.5 433.3 424.0 429.6 392.9 449.4 371.5 400.3 338.0 464.9 381.6 350.7 452.4 435.2 390.6 418.9 472.0 392.0 386.0 378.3 391.3 390.7 419.7 413.4 375.7 423.0 417.0 472.5 393.9 393.4 407.9 438.5 401.4 398.2 401.7 410.4 399.1 412.8 364.6 427.2 387.8 D ay 28 410.4 404.1 379.5 402.8 448.1 461.1 452.9 462.1 427.9 485.4 398.4 438.8 293.0 504.9 406.6 380.3 481.7 463.2 421.9 453.0 504.2 419.9 418.6 408.7 418.1 422.9 459.2 444.6 401.0 443.7 . 453.8 510.6 423.4 423.0 433.1 469.3 431.7 429.9 432.6 445.4 432.0 451.1 396.0 458.1 422.6 583 WEIGHTS (g) D ay 35 D ay 42 432.4 433.9 395.6 428.6 468.1 479.9 478.7 494.2 451.3 519.7 419.7 466.9 318.3 531.9 432.8 404.3 509.5 494.3 462.4 486.5 529.5 442.6 440.5 427.5 441.2 453.2 491.9 471.4 422.8 460.0 481.1 536.8 445.5 446.3 454.4 495.8 456.2 455.8 447.4 453.8 460.5 482.7 415.6 494.4 451.1 448.2 454.7 412.4 447.8 478.6 501.6 492.4 515.9 473.5 531.7 429.6 497.5 357.7 551.7 452.6 420.2 538.4 512.5 491.5 499.0 546.7 460.5 453.6 455.7 465.2 472.4 514.7 490.6 435.8 476.8 497.0 557.7 463.3 464.2 475.2 507.4 391.0 471.5 460.5 466.9 475.4 504.1 426.2 505.0 459.7 D ay 49 463.5 440.2 410.4 447.5 473.4 503.5 496.8 502.7 471.6 534.4 420.4 509.1 354.8 570.6 456.0 426.6 543.2 533.8 498.0 511.7 558.3 457.8 460.7 449.7 477.0 484.5 523.2 495.6 450.4 488.8 505.9 586.7 474.5 473.1 477.6 518.9 439.6 485.6 471.7 481.2 458.4 519.9 437.9 525.8 483.8 DuPont-5386 D ay 56 480.8 454.9 426.4 451.1 493.0 417.0 523.4 510.7 ,, 461.7 545.2 430.5 515.7 369.1 570.5 391.6 383.9 544.4 549.3 513.0 517.0 499.3 470.7 468.7 478.5 490.5 495.0 527.8 510.3 464.1 495.0 510.0 583.4 481.8 479.3 481.7 534.8 456.7 496.6 462.3 505.3 458.2 525.5 448.8 525.9 496.5 Company Sanitised. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D a y 63 D ay 70 M a le , V II - 250 mg/k g /d a y 543194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 487.4 477.1 445.3 473.8 497.7 470.9 532.0 532.0 469.7 568.0 423.1 514.8 368.7 587.5 389.3 398.5 548.8 558.9 514.5 482.2 531.7 426.0 457.2 444.8 489.0 501.4 507.5 494.7 473.8 508.7 519.4 5 7 9 .0. 458.2 477.3 497.9 539.4 479.0 505.6 437.7 481.6 434.2 534.5 431.8 489.4 508.1 501.3 369.1 446.4 489.8 426.3 485.5 537.0 532.0 495.7 578.6 394.7 523.6 369.4 595.6 337.8 423.4 453.0 573.0 457.9 478.4 487.8 396.8 439.9 474.1 480.2 502.0 518.2 520.8 480.4 511.1 530.9 499.3 375.0 393.0 511.2 427.7 480.1 504.8 444.3 500.0 460.8 537.4 427.7 437.7 510.8 D ay 74 D ay 77 D ay 84 373.5 513.8 561.0 491.4 462.4 AK T E ST DAY 70 430.7 434.7 488.8 438.6 454.9 529.3 515.9 472.5 512.5 487.3 559.5 414.4 459.2 511.7 502.9 451.7 453.5 463.5 487.2 506.9 492.7 549.4 453.6 580.3 440.3 527.4 351.7 595.9 420.7 509.0 515.4 416.0 502.3 455.7 485.3 393.2 525.3 396.1 504.5 518.8 502.2 458.6 497.2 515.2 537.3 530.1 564.4 498.0 590.3 443.4 547.2 386.9 624.5 432.9 528.1 563.5 473.8 521.7 470.0 518.5 481.1 549.2 454.6 512.2 D ay 90 532.9 530.3 463.6 501.1 533.1 562.2 544.4 576.8 509.9 596.3 471.1 543.9 394.5 628.3 456.8 545.3 581.2 498.5 528.7 476.1 543.5 508.2 564.1 458.5 503.6 D a y 98 482.4 549.7 408.2 643.9 454.9 555.1 593.9 512.8 538.2 483.6 545.0 536.6 576.8 476.0 536.2 D ay 105 497.2 543.2 407.9 661.0 457.9 568.1 610.2 532.9 557.9 485.4 553.3 532.6 580.3 477.6 548.4 DuPont-5386 D ay 112 * 471.8 548.0 413.9 678.4 454.9 570.1 618.5 537.0 568.4 498.2 578.2 544.9 593 .2 482.1 550.9 584 Company Sanitized. Dees netcontain TSCA CBl H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 119 D ay 126 M a le , V II - 250 mg/k g /d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 483.5 554.9 411.6 694.2 466.1 576.3 627.0 539.7 575.0 515.5 570.9 560.3 591.6 495.6 566.1 493.1 550.8 421.1 708.0 477.0 D ay 133 511.7 574.8 429.9 726.3 487.8 D ay 140 526.6 582.0 446.5 728.7 499.4 D ay 147 547.4 609.1 454.5 743.7 513.4 D ay 154 560.7 610.6 460.9 750.7 528.9 D ay 161 567.8 622.9 470.7 756.5 551.5 D ay 168 585.2 637.2 479.4 782.9 554.0 DuPont-5386 D ay 175 5 9 6 . 1 643.6 484.4 782.6 546.5 585 Company Sanitized Poes not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) D ay 181 M a le , V I I - 250 ntg/k g / d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 5 7 5 .2 619.1 4 5 7 .7 770.5 522.5 DuPont-5386 586 Company Sanitised. Coes not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 0 Day 7 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 173.9 184.0 161.9 1 8 1 .9 189.3 224.2 1 7 4 .1 1 8 2 .1 184.2 162.0 178.9 167.2 2 1 3 .8 177.2 190.9 185.0 170.9 2 1 2 .5 188.6 197.8 197.9 186.0 2 0 2 .8 185.6 184.2 2 0 7 .1 209.9 2 0 9 .5 176.5 191.1 221.0 1 9 4 .8 ' 191.3 177.5 183.8 214.9 2 0 2 .5 209.3 183.1 205.4 2 0 3 .0 172.6 201.4 191.5 197.9 202.3 212.6 185.0 185.2 2 1 4 .0 2 4 3 .9 188.9 201.4 2 0 8 .4 173.4 193.2 1 8 9 .9 219.3 194.5 215.3 214.3 185.4 228.4 226.2 226.6 228.3 206.9 234.0 225.3 2 0 3 .9 234.3 2 4 3 .5 246.8 183.6 213.2 2 4 1 .8 2 2 8 .2 224.8 201.2 216.5 2 4 0 .1 231.0 2 2 9 .9 2 0 7 .8 2 4 3 .7 2 2 3 .1 188.2 216.4 2 1 1 .0 2 1 7 .5 D a y 14 213.3 2 3 0 .6 2 0 7 .7 190.6 222.4 265.8 209.5 225.0 236.4 191.7 221.3 204.0 243.7 2 1 0 .7 2 3 6 .1 2 2 9 .7 210.4 248.5 2 3 8 .0 2 3 9 .1 241.9 2 1 9 .7 256.4 249.2 2 1 5 .5 250.7 263.2 261.6 2 0 4 .5 223.4 272.9 2 4 4 .9 240.8 209.6 224.3 2 6 5 .7 2 4 3 .4 2 2 9 .8 231.4 256.1 252.2 206.3 247.9 236.9 237.7 D ay 21 236.3 2 4 0 .1 2 1 6 .1 208.4 2 5 8 .1 2 6 8 .1 2 2 9 .0 243.1 2 5 3 .7 2 1 0 .1 2 3 3 .9 2 2 0 .5 266.7 2 1 6 .6 2 4 9 .1 2 5 3 .6 2 2 8 .8 2 5 7 .1 2 5 1 .0 253.8 268.5 229.4 2 6 1 .7 2 6 2 .7 234.4 279.8 2 8 6 .5 2 7 9 .7 2 0 5 .7 2 4 0 .7 2 8 6 .9 257.4 257.0 227.7 239.7 283.8 266.5 245.3 259.8 2 7 3 .9 269.6 2 2 0 .9 265.0 2 5 4 .7 264.4 Day 28 2 3 9 .5 246.9 226.2 2 0 8 .0 2 7 2 .6 292.2 243.0 2 5 8 .1 258.8 2 1 7 .9 239.9 219.5 278.2 233.0 261.6 262.2 2 4 1 .5 2 7 3 .3 2 6 6 .2 2 7 0 .1 2 7 3 .2 243.2 288.6 2 7 0 .7 238.9 28 5 ,.6 305.0 2 9 1 .4 227.2 255.4 300.7 286.9 269.9 236.6 2 5 1 .7 304.6 2 7 8 .5 270.4 2 7 3 .1 301.4 279.1 239.0 290.6 274.2 2 7 3 .5 D ay 35 2 6 4 .5 256.5 243.6 2 2 1 .8 284.2 305.4 262.2 2 7 1 .7 276.8 226.2 248.3 2 3 8 .0 274.2 236.7 279.6 280.2 2 6 2 .6 285.3 2 7 7 .0 2 8 6 .8 2 9 3 .7 253.5 302.6 277.2 253.9 319.5 324.2 307.3 234.0 257.2 321.8 300.3 289.4 243.3 2 5 4 .8 318.5 2 9 2 .7 281.9 291.4 2 9 6 .6 290.8 254.1 2 9 8 .5 294.2 285.9 D ay 42 271.1 268.4 245.8 226.2 2 9 3 .1 309.4 2 6 0 .7 274.1 282.4 2 4 3 .8 251.4 244.3 287.1 239.9 271.6 284.2 263.2 303.4 277.3 284.5 303.7 262.0 2 9 7 .6 287.7 266.3 331.2 336.5 319.6 239.8 2 6 4 .7 3 2 2 .6 309.3 2 9 9 .1 2 4 8 .7 2 6 5 .8 340.3 2 9 8 .9 2 8 2 .5 2 9 7 .1 3 0 7 .6 3 0 7 .7 2 6 1 .8 311.8 2 9 3 .1 299.4 Day 49 272.7 279.9 255.2 237.6 318.8 308.3 272.0 276.8 285.2 259.4 267.0 2 5 9 .7 2 9 7 .7 2 4 9 .6 2 8 4 .3 295.4 274.4 316.6 2 9 1 .1 2 8 9 .9 3 0 9 .9 274.8 3 1 5 .1 3 0 1 .9 2 7 0 .9 347.8 349.3 330.3 244.3 272.6 3 4 4 .7 319.4 307.8 2 6 1 .0 2 6 9 .7 3 5 4 .6 307.3 2 8 0 .5 301.9 315.4 315.2 266.3 3 1 8 .1 307.0 309.7 DuPont-5386 D ay 56 2 7 0 .8 2 8 2 .6 2 5 9 .8 2 5 6 .2 3 3 1 .0 3 2 7 .7 2 8 8 .1 2 9 5 .9 2 9 2 .0 2 6 5 .0 2 6 4 .8 2 7 5 .1 305.4 2 4 6 .7 281.9 300.6 282.9 321.1 2 8 0 .6 3 0 0 .3 319.1 285.7 335.0 293.6 275.6 352.1 359.1 340.8 264.2 274.3 336.3 329.8 3 1 1 .8 2 6 9 .2 280.3 357.7 3 1 7 .8 3 0 0 .5 3 1 8 .9 3 2 6 .1 3 1 9 .1 2 7 0 .6 3 1 5 .9 317.8 3 2 2 .5 587 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 63 D ay 70 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 281.2 292.0 269.3 260.1 342.4 333.9 296.2 288.4 303.9 272.8 270.0 278.4 301.6 251.9 295.6 2 9 8 .5 270.5 3 1 3 .1 287.6 2 9 8 .5 316.1 288.8 328.8 296.3 279.2 358.5 360.0 344.4 2 4 9 .6 2 7 6 .1 343.3 333.1 320.0 271.9 282.2 3 5 4 .1 316.2 310.2 321.8 347.8 320.1 276.1 3 2 9 .7 323.0 338.8 2 8 5 .9 3 0 4 .5 276.6 264.3 353.0 336.2 2 9 7 .9 2 9 8 .9 305.2 2 8 0 .0 2 7 4 .9 2 9 0 .1 314.4 2 5 5 .6 2 9 9 .1 306.6 2 8 8 .4 323.6 2 9 3 .9 294.6 318.4 2 9 2 .4 327.9 3 0 4 .9 2 8 6 .5 358.2 358.2 355.4 263.0 278.1 342.8 335.7 325.9 268.0 282.2 367.3 3 2 6 .1 310.7 333.9 373.1 333.4 281.3 3 2 9 .7 333.3 338.4 D ay 74 307.9 2 7 7 .6 320.8 2 8 7 .6 302.6 321.2 294.2 323.5 306.4 284.3 354.9 361.2 3 5 1 .7 2 6 5 .9 2 7 6 .5 345.5 332.8 325.0 267.4 277.0 INDIVIDUAL BODY WEIGHTS (g) D ay 77 D a y 84 D ay 91 2 8 4 .0 313.1 273.0 263.3 359.9 336.7 295.6 301.7 309.7 283.8 271.2 297.3 314.8 260.0 303.2 ' 286.8 313.7 272.5 257.9 378.1 341.3 303.8 307.2 315.8 284.8 286.0 2 9 6 .9 3 2 4 .1 2 6 8 .0 311.0 2 9 7 .9 327.7 2 8 0 .6 2 4 9 .7 395.0 351.3 309.2 323.9 312.4 286.8 280.1 3 0 1 .1 324.8 267.4 299.3 358.9 324.2 310.6 3 4 1 .8 381.4 330.6 2 7 9 .8 328.3 330.3 342.4 3 6 0 .0 325.4 312.6 349.9 395.9 334.7 288.5 332.9 339.9 339.6 365.3 333.7 315.4 351.7 400.2 332.0 234.3 328.2 339.4 346.1 D ay 98 2 8 0 .8 282.9 329.8 2 6 6 .7 319.0 377.7 333.3 346.0 359.8 4 1 8 .5 352.3 269.3 346.5 349.8 349.0 DuPont-5386 D ay 105 D ay 112 . 2 9 0 .0 2 6 3 .4 330.2 2 7 4 .8 316.7 2 9 5 .5 2 7 9 .6 3 3 9 .4 2 8 3 .7 3 1 3 .3 3 8 5 .9 347.2 3 5 0 .7 373.3 426.3 355.3 287.3 3 2 6 .1 367.2 361.7 389.2 374.8 3 5 0 .0 387.4 447.5 3 6 4 .9 301.3 SE T E S T DAY 369.0 374.0 588 CompanySanitized. Doesnotcontain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 119 D ay 126 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2 8 7 .9 280.1 318.3 287.1 319.1 278.4 281.8 3 1 9 .5 281.6 301.8 3 8 9 .5 384.6 350.9 395.3 4 5 0 .3 368.2 301.9 SE T E ST DAY 105 3 6 5 .1 378.5 D ay 133 293.4 296.8 331.6 296.9 323.4 INDIVIDUAL BODY WEIGHTS (g) D ay 140 D ay 147 D ay 154 2 9 3 .8 303.9 329.2 290.9 321.1 298.5 313.5 334.5 302.0 328.0 295.0 322.1 349.1 295.1 320.2 D ay 161 2 9 9 .2 3 2 2 .7 352.3 3 1 4 .9 325.3 D ay 168 3 0 5 .0 340.6 3 5 6 .5 311.9 334.0 DuPont-5386 D ay 175 303.8 3 3 4 .0 3 5 5 .8 3 1 4 .1 333.0 589 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 181 F e m a le , IX - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 294.9 312.7 345.9 294.6 315.0 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 590 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 D ay 14 F e m a l e , XV - 25 m g/ k g / d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 175.0 2 0 1 .1 174.8 193.5 184.4 194.5 193.2 175.9 179.6 175.9 184.6 173.3 208.1 168.6 192.5 183.9 169.8 2 0 8 .9 200.3 2 0 5 .8 2 0 2 .8 196.6 225.8 185.1 2 2 4 .1 194.4 194.4 190.4 195.7 205.7 2 1 7 .1 2 0 4 .9 1 6 5 .8 ' 189.6 198.5 189.2 2 3 1 .6 194.6 218.3 2 0 7 .5 2 2 8 .9 2 0 8 .1 202.3 194.8 1 8 6 .6 2 0 2 .4 AK T E ST DAY 0 224.3 187.7 204.3 196.2 185.7 2 3 7 .1 218.2 225.2 230.0 215.2 262.3 206.4 2 5 1 .8 2 1 9 .9 228.8 2 1 9 .8 230.4 2 1 8 .5 2 5 1 .8 2 2 3 .3 189.0 209.2 2 2 5 .8 2 0 1 .5 254.6 2 3 3 .7 240.2 215.6 238.2 209.3 219.8 216.2 2 0 9 .7 2 1 4 .9 239.8 205.8 2 2 3 .1 227.6 214.4 255.4 2 3 7 .1 247.8 2 5 4 .8 237.3 2 7 3 .5 226.6 270.8 228.9 251.3 237.0 2 5 6 .1 244.2 249.4 242.0 199.8 230.4 245.3 INDIVIDUAL BODY WEIGHTS (g) D ay 21 D ay 28 D ay 35 D ay 42 2 2 3 .6 2 8 4 .1 247.0 268.4 236.2 264.3 233.8 242.6 230.8 2 2 7 .7 225.2 269.2 218.0 246.3 242.2 239.4 275.7 2 5 8 .7 2 6 6 .7 2 7 4 .1 249.4 302.3 242.2 2 9 8 .1 256.2 2 7 3 .9 2 5 6 .7 2 7 6 .5 2 7 4 .0 2 7 6 .7 263.6 212.9 253.0 255.0 240.3 283.8 265.5 285.2 240.3 274.9 236.7 256.0 244.4 239.4 228.9 270.0 231.8 253.8 256.1 247.4 2 9 1 .9 291.2 2 7 8 .7 2 8 7 .5 279.3 314.5 2 6 1 .8 305.3 264.5 282.1 268.8 300.1 3 0 0 ..6 288.2 276.4 .2 2 8 . 2 256.8 267.1 249.5 303.4 275.9 294.2 262.0 288.1 SE T E ST DAY 29 270.0 258.1 248.0 247.9 257.3 3 0 7 .5 2 8 2 .5 305.4 2 7 5 .2 301.2 266.3 264.3 2 5 8 .9 254.2 279.4 239.2 260.0 268.5 260.8 304.4 294.0 284.8 299.1 286.0 351.5 270.4 319.3 278.4 296.8 274.4 313.3 305.0 303.7 285.2 241.3 2 6 8 .9 2 7 5 .1 2 8 3 .5 2 5 3 .1 2 7 5 .6 2 8 0 .0 273.3 314.2 2 8 5 .1 295.3 317.5 2 9 8 .1 366.9 2 8 9 .1 3 3 4 .5 285.4 306.4 2 9 3 .5 325.4 3 1 5 .9 329.3 2 9 0 .5 247.3 2 7 1 .0 2 8 9 .3 D ay 49 2 7 0 .2 312.3 293.3 308.7 2 8 0 .6 3 1 2 .6 2 7 8 .5 2 6 6 .4 2 6 7 .1 2 6 0 .4 303.0 2 5 4 .4 2 8 1 .5 2 8 7 .8 2 7 7 .8 3 2 4 .0 3 1 1 .8 2 9 9 .6 3 2 4 .0 297.6 380.6 2 9 9 .1 3 3 6 .9 2 8 9 .3 3 2 2 .7 2 9 6 .5 3 3 5 .0 323.2 336.5 2 6 7 .3 2 5 1 .2 2 8 2 .9 291.5 DuPont-5386 D ay 56 27413 3 2 1 .1 3 1 6 .6 3 2 2 .5 245.9 3 1 5 .2 2 8 7 .1 284.4 ,2 7 1 . 2 2 5 4 .0 296.1 265.7 283.3 290.5 281.0 319.8 3 0 1 .9 3 0 3 .1 327.3 299.3 3 8 7 .5 297.5 3 5 4 .2 2 9 8 .4 3 2 0 .1 305.3 3 4 9 .6 3 2 9 .0 3 2 2 .6 2 9 8 .2 2 6 3 .4 2 8 2 .3 2 9 2 .7 591 Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 63 D ay 70 F e m a l e , XV - 25 m g/ k g / d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2 8 3 .6 334.4 304.9 330.6 2 9 2 .7 312.4 290.8 279.5 274.3 268.7 308.4 275.7 289.3 2 8 9 .7 2 8 7 .8 3 2 7 .6 309.2 2 9 8 .6 330.8 302.6 392.2 296.2 355.4 301.4 3 1 7 .5 3 0 5 .7 3 5 5 .1 344.7 339.2 2 9 8 .9 2 7 2 .4 . 2 8 7 .6 300.2 2 8 1 .6 349.3 319.6 3 4 1 .4 306.2 3 1 6 .7 2 8 9 .9 295.4 285.8 2 7 1 .5 312.3 282.5 303.5 302.5 2 9 4 .6 328.9 314.2 309.9 335.1 313.8 398.6 305.9 365.2 2 9 5 .7 318.8 3 0 7 .8 3 5 6 .7 343.7 331.6 305.3 266.8 293 .4 3 1 0 .1 . D ay 74 301.2 292.5 328.3 312.9 306.0 337.8 305.3 395.9 3 0 2 .5 368.6 307.5 274.5 311.1 360.7 341.2 341.2 310.8 269.0 2 9 4 .6 303.2 INDIVIDUAL BODY WEIGHTS (g) D ay 77 D ay 84 D ay 91 288.3 355.7 322.6 3 4 9 .5 298.3 319.8 2 9 4 .8 300.6 295.2 2 6 7 .6 3 0 4 .9 2 7 8 .7 298.3 2 9 1 .1 361.8 3 3 1 .7 348.7 295.8 3 2 5 .7 304.5 299.7 299.8 273.0 304.7 2 8 4 .7 300.4 286.8 359.1 328.6 353.5 2 9 0 .1 323.4 303.1 303.1 296.5 280.9 312.6 294.6 302.8 D a y 98 2 8 8 .4 330.0 2 9 4 .7 309.3 D ay 105 2 8 3 .7 3 2 9 .7 297.8 319.4 DuPont-5386 D ay 112 , 290.3 339.8 312.3 325.9 592 Company Sanitized- Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 119 D ay 126 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2 9 3 .3 3 4 6 .9 3 1 7 .0 325.5 2 8 9 .2 345.8 315.7 320.1 D ay 133 298.2 358.8 321.9 3 3 0 .6 INDIVIDUAL BODY WEIGHTS (g) D ay 140 D ay 147 D ay 154 294.8 3 6 5 .1 3 2 9 .7 344.4 307.3 376.2 3 2 6 .5 344.8 314.6 371.9 340.6 3 4 9 .9 D ay 161 309.8 380.4 334.1 353.0 D ay 168 313.3 3 8 7 .9 337.7 355.6 DuPont-5386 D ay 175 3 1 9 .4 389.6 343.4 3 5 1 .5 593 Company Sanitized. Does not contain TSCA CBi H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 181 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2 9 9 .7 3 6 8 .1 326.8 3 4 3 .1 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 594 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 186.5 184.6 171.5 173.6 194.9 214.8 203.2 164.8 174.8 166.7 184.6 180.3 184.9 161.6 192.7 179.7 178.2 2 1 8 .7 1 9 3 .5 186.8 2 0 2 .1 177.0 175.8 2 0 8 .5 183.3 2 1 0 .7 166.3 192.8 187.4 185.5 199.9 201.3 2 0 0 .7 184.6 194.0 212.9 2 0 3 .1 1 9 8 .5 202.4 220.2 255.4 2 2 8 .9 180.3 197.1 191.8 213.6 202.4 206.0 184.6 2 2 6 .1 2 1 2 .1 206.3 2 3 7 .1 216.6 215.2 222.8 205.0 2 0 0 .8 2 4 0 .9 2 0 6 .6 220.8 196.0 2 1 1 .6 210.6 198.9 2 2 0 .0 2 2 1 .1 2 1 9 .1 206.3 224.8 D ay 14 230.5 221.6 221.2 213.3 234.2 276.3 250.1 197.1 207.6 2 1 2 .9 2 3 2 .9 207.8 218.5 201.6 2 3 6 .1 2 3 3 .1 2 2 3 .6 2 7 5 .6 2 3 6 .5 2 3 1 .0 253.3 229.4 218.6 259.5 2 2 8 .8 2 5 3 .6 2 1 3 .2 227.4 2 3 2 .6 226.9 228.4 2 4 9 .5 244.1 2 2 9 .1 2 4 8 .5 INDIVIDUAL BODY WEIGHTS (g) D ay 21 D ay 28 D ay 35 247.8 2 4 3 .7 2 3 0 .7 2 3 3 .0 258.0 2 9 4 .8 272.3 2 1 4 .9 2 1 9 .9 234.8 2 5 0 .0 2 3 4 .6 2 3 6 .7 2 2 2 .1 2 6 6 .0 2 5 2 .5 2 3 9 .9 278.4 2 5 2 .6 241.2 2 6 7 .7 2 3 4 .1 2 2 6 .0 2 8 5 .9 244.2 2 7 3 .9 2 1 9 .7 2 4 0 .7 248.6 2 4 0 .9 2 5 0 .6 261.8 253.5 2 3 9 .7 261.3 261.8 240.7 2 4 6 .6 2 4 8 .9 2 6 8 .4 300.1 282.4 223.3 2 3 2 .9 243.8 253.0 198.4 2 4 4 .1 233.0 2 7 9 .9 2 6 3 .7 2 6 0 .9 300.3 2 6 3 .9 2 6 1 .5 280.8 2 6 2 .1 243.6 311.0 257.9 2 9 3 .9 2 4 5 .7 256.8 251.8 2 6 1 .5 2 6 2 .9 2 8 1 .6 2 6 3 .6 2 4 3 .9 2 7 5 .1 271.3 262.6 262.5 264.0 279.4 324.3 287.8 236.7 242.0 248.0 259.9 196.4 249.2 222.3 279.0 278.5 263.9 307.3 275.1 273.7 293.4 267.5 251.3 284.4 264.2 297.9 254.1 270.6 270.3 269.2 273.5 294.9 279.9 260.7 289.0 D ay 42 2 8 0 .8 262.8 2 6 1 .6 283.5 2 7 9 .6 331.7 2 9 4 .8 2 5 5 .7 2 5 9 .0 266.2 2 7 0 .9 188.6 2 6 3 .6 2 4 8 .7 300.4 2 9 6 .5 275.4 3 1 9 .7 283.2 277.8 292.4 2 8 3 .5 267.8 275.3 269.3 310.8 2 7 3 .1 2 8 4 .7 282.3 285.2 277.2 300.6 2 9 6 .4 263.3 302.4 D ay 49 278.3 2 8 4 .1 2 6 9 .5 2 8 5 .5 287.3 3 1 4 .7 2 9 9 .7 2 5 1 .1 250.8 2 5 5 .7 2 7 3 .0 2 2 4 .8 2 6 8 .6 2 5 6 .5 3 0 7 .0 2 9 6 .9 2 8 3 .0 322.4 2 8 9 .5 303.2 3 1 0 .7 2 9 0 .7 267.3 3 0 8 .9 2 7 5 .6 317.0 2 7 4 .9 2 9 9 .4 2 8 2 .3 2 8 9 .4 2 9 3 .2 306.8 305.5 2 7 5 .0 310.4 DuPont-5386 D ay 56 279.'6 2 9 3 .3 2 6 8 .8 2 8 4 .5 2 9 6 .8 323.3 3 0 3 .5 249.5 257.7 267.3 275.0 231.8 269.2 259.9 293 .4 306.1 284.9 311.2 296.2 304.0 308.3 290.5 2 7 5 .8 304.4 283.8 321.2 284.0 300.6 287.6 291.3 292.5 313 .4 309.1 272.2 311.5 CM pa"1,Sanl,i" ` D e s not contain t sc a c b , H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 63 D a y 70 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2 8 9 .7 290.2 2 7 2 .4 2 9 7 .5 2 9 2 .2 327.7 3 0 5 .1 264.3 262.5 274.2 2 8 5 .9 2 3 8 .9 274.3 2 5 1 .7 3 0 7 .2 3 0 5 .6 2 9 0 .1 318.3 2 9 3 .9 309.2 308.6 299.4 2 6 9 .8 319.2 2 8 4 .1 330.6 2 8 5 .5 3 0 7 .5 2 8 4 .5 305.4 2 8 4 .7 3 1 6 .7 304.0 275.8 317.1 290.8 3 1 2 .1 272.6 3 0 5 .7 304.5 320.5 315.7 274.5 264.9 290.8 2 9 6 .4 252.4 2 8 2 .7 2 6 4 .8 300.3 316.3 293.2 315.6 292.5 3 1 3 .7 315.1 3 0 6 .1 2 7 8 .1 338.6 280.4 325.5 288.0 317.3 290.3 308.8 2 8 1 .6 313.4 313.6 2 8 4 .2 316.9 D a y 74 316.2 296.9 314.7 290.6 310.0 323.7 311.0 274.0 298.5 274.5 327.7 291.0 317.5 286.8 310.7 291.6 315.1 309.9 280.5 315.3 INDIVIDUAL BODY WEIGHTS (g) D ay 77 D a y 84 D a y 91 295.4 315.7 278.2 307.6 302.7 324.3 314.9 2 7 5 .9 2 6 3 .4 290.4 2 9 3 .6 257.3 284.2 2 6 0 .8 317.6 294.0 315.0 2 7 6 .7 311.5 3 0 5 .7 316.9 320.3 271.2 2 7 0 .1 293.3 302.8 . 254.5 298.9 261.2 311.3 295.7 319.2 281.9 313.0 315.0 328.1 318.3 277.0 270.6 2 8 6 .1 300.7 258.5 2 9 6 .6 261.3 314.5 D a y 98 306.2 270.7 2 9 8 .2 256.5 301.6 D ay 105 3 0 6 .5 276.0 301.9 2 6 7 .9 3 0 5 .8 DuPont-5386 D ay 112 '3 1 8 .8 2 7 0 .9 3 1 1 .1 227.2 3 1 4 .1 596 Company Sanitized. Does not contain TSCA CBS H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 119 D ay 126 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 321.8 2 2 0 .9 312.3 2 4 2 .5 313.6 317.8 263.9 311.3 248.1 325.1 D ay 133 317.5 277.8 329.7 2 6 5 .7 316.3 INDIVIDUAL BODY WEIGHTS (g) D ay 140 D ay 147 D ay 154 3 2 3 .5 2 7 8 .1 321.6 265.2 327.2 3 3 3 .9 2 8 1 .1 327.2 269.6 3 4 2 .7 334.4 281.5 342.6 283.6 338.3 D ay 161 339.7 2 9 1 .7 3 3 8 .9 280.0 3 4 8 .5 D ay 168 3 4 1 .4 2 9 3 .1 3 4 2 .1 2 8 1 .5 3 5 1 .7 DuPont-5386 D ay 175 3 4 8 .0 294.2 342.2 2 8 3 .3 364.6 597 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 181 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 327.2 286.1 328.1 277.7 356.8 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 598 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 F e m a l e , V I I I - 250 mg/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 186.4 202.6 195.9 181.0 168.9 173.1 166.9 191.2 184.7 196.2 1 6 9 .0 1 9 6 .1 180.8 164.2 2 2 4 .7 197.0 1 8 1 .1 2 1 7 .9 1 8 1 .7 197.2 2 0 5 .9 175.6 211.6 181.8 190.6 188.2 196.4 209.8 2 0 6 .8 2 0 1 .9 172.8 193.0 2 1 6 .0. 204.2 189.5 175.6 205.8 188.1 178.2 186.6 1 8 9 .9 2 0 3 .8 168.8 192.9 171.0 212.8 2 3 9 .1 2 2 1 .5 198.5 192.0 187.3 190.0 211.5 212.0 213.7 194.4 215.4 210.2 185.1 246.4 2 2 6 .2 201.7 250.1 2 0 8 .0 2 2 0 .0 230.4 196.4 2 3 4 .6 198.0 2 2 0 .0 215.3 227.8 245.4 2 5 3 .5 233.3 196.1 215.4 2 3 7 .4 2 2 7 .7 213.7 197.7 251.0 210.9 203.9 207.0 215.8 2 2 9 .6 189.3 2 2 1 .5 190.9 D ay 14 2 3 3 .2 2 6 1 .6 2 4 6 .1 216.8 217.0 202.0 211.3 240.5 2 3 9 .1 2 4 4 .9 210.4 236.2 220.6 204.0 2 6 6 .1 240.3 213.8 278.8 2 2 1 .6 2 3 4 .7 244.6 223.4 261.2 223.5 243.6 234.9 249.3 271.6 275.5 256.6 217.5 232.4 275.6 258.2 2 3 2 .5 224.4 2 7 4 .7 230.8 2 2 7 .9 2 2 6 .9 235.4 244.6 217.8 244.5 220.3 INDIVIDUAL BODY WEIGHTS (g) D ay 21 D ay 28 D ay 35 2 4 4 .7 2 9 4 .3 2 5 6 .2 2 2 4 .9 234.4 2 2 7 .1 227.2 257.6 249.3 2 5 2 .2 231.3 2 5 0 .6 227.3 222.6 291.6 252.2 230.6 298.3 242.8 2 5 1 .0 2 6 4 .1 2 3 7 .1 2 8 4 .3 235.3 2 6 1 .0 2 3 7 .1 261.7 2 9 3 .6 292.2 268.0 236.5 2 5 0 .4 2 8 8 .9 2 7 2 .6 2 4 5 .3 2 2 2 .7 2 8 8 .9 230.3 242.4 235.8 2 5 4 .4 255.8 221.8 2 5 6 .7 230.8 2 5 2 .1 289.3 268.3 234.3 2 5 1 .6 232.4 2 4 4 .1 2 6 8 .5 278.2 2 6 9 .5 240.8 2 5 9 .1 236.8 238.4 300.9 2 7 0 .5 245.8 314.8 2 5 1 .7 265.5 281.5 2 5 0 .6 290.3 246.3 2 7 4 .8 259.4 281.8 310.1 313.9 2 7 6 .1 253.8 2 5 3 .1 2 9 9 .7 289.3 249.2 232.8 2 8 9 .7 2 5 2 .4 2 4 6 .9 2 3 5 .6 2 6 2 .5 275.1 230.0 2 7 0 .1 2 4 5 .1 266.7 318.3 282.7 241.2 257.1 2 5 1 .3 257.4 2 7 0 .6 289.4 282.0 2 5 2 .7 262.6 2 5 5 .5 2 4 0 .6 310.2 278.2 251.6 314.6 257.9 278.4 2 9 6 .5 261.7 2 9 8 .1 2 5 7 .8 2 8 8 .5 2 6 7 .9 2 9 0 .7 321.3 326.1 301.4 259.6 275.3 310.2 297.3 2 6 3 .1 2 4 1 .7 3 1 2 .7 259.2 2 5 1 .5 2 4 7 .7 2 6 9 .1 284.2 2 3 5 .1 2 8 0 .7 2 5 4 .0 D ay 42 2 7 6 .0 334.2 2 8 9 .1 248.6 279.8 268.7 260.3 285.3 294.2 280.0 259.7 267.0 275.6 253.4 320.1 287.0 2 6 1 .6 322.6 262.1 283.2 306.4 2 7 0 .6 308.5 256.3 304.4 2 8 0 .4 2 8 7 .5 325.2 330.2 306.8 2 6 3 .7 284.8 316.6 309.1 266.1 251.5 318.8 264.2 269.6 250.9 276.5 300.4 2 5 0 .6 2 8 7 .8 2 6 6 .9 DuPont-5386 D ay 49 D ay 56 2 7 4 .7 338.0 2 9 2 .7 2 5 2 .3 2 7 2 .8 261.3 266.3 2 8 5 .7 307.0 2 9 7 .1 2 6 4 .4 2 7 4 .7 2 9 4 .6 239.3 3 2 6 .5 2 8 6 .1 2 6 2 .2 339.8 2 7 0 .1 2 8 8 .6 3 2 0 .1 2 7 4 .9 314.8 2 7 3 .7 315.4 2 3 2 .2 2 9 4 .8 3 3 6 .7 333.2 311.8 269.2 297.3 3 1 7 .1 3 1 5 .5 2 8 3 .6 2 5 9 .9 287.3 2 1 9 .7 2 7 2 .0 2 5 8 .3 2 8 9 .9 3 1 3 .1 2 5 7 .1 305.0 269.6 2 7 9 '.5 329.9 3 0 2 .5 254.3 287.5 252.4 269.5 2 8 6 .6 3 1 0 .1 3 0 0 .5 271.3 2 7 3 .7 2 7 6 .4 178.9 333.3 2 8 4 .9 2 6 1 .4 3 3 6 .5 2 7 1 .6 292.2 3 1 9 .9 269.2 2 9 0 .1 2 6 8 .3 325.4 AK TEST DAY 2 9 7 .2 334.2 3 3 1 .9 292.2 2 6 6 .6 2 9 9 .4 3 2 3 .9 3 0 5 .6 2 8 1 .0 2 5 6 .4 2 3 8 .7 2 3 0 .1 2 3 5 .9 2 5 5 .3 2 8 1 .8 3 1 2 .1 2 5 1 .5 2 9 3 .1 2 7 1 .4 599 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D a y 63 D ay 70 D a y 74 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 283.2 3 0 8 .7 307.5 251.8 280.2 246.8 268.6 272.0 3 1 7 .7 274.4 2 6 5 .1 2 8 7 .2 2 9 0 .1 2 3 5 .9 334.5 2 7 5 .8 260.3 323.0 2 7 6 .1 2 9 5 .1 313.1 2 6 7 .2 240.7 269.8 328.3 251.4 332.5 332.0 279.3 2 4 9 .8 310.3 324.1 305.6 279.2 265.8 306.1 249.6 268.3 2 1 0 .5 2 8 8 .1 270.3 254.3 2 6 3 .5 271.8 285.9 2 9 7 .0 307.5 250.0 291.0 2 6 8 .7 274.4 284.0 325.5 FD T E ST DAY 69 252.3 292.4 2 9 1 .1 2 4 7 .5 342.4 231.5 255.4 320.5 279.0 2 9 2 .5 298.3 2 0 4 .8 1 9 5 .7 2 2 9 .9 2 8 1 .5 214.9 229.0 326.6 283.5 2 8 9 .5 283.0 2 6 1 .7 269.0 278.6 325.4 2 9 7 .8 324.5 325.9 2 8 8 .7 261.0 315.7 332.2 2 7 9 .8 2 6 3 .7 2 6 3 .7 324.2 2 4 8 .7 2 6 8 .2 262.0 287.1 262.8 261.6 2 9 9 .5 274.2 310.2 331.4 297.6 2 6 7 .5 2 3 2 .5 316.9 326.0 2 9 7 .9 221.0 INDIVIDUAL BODY WEIGHTS (g) D ay 77 D ay 84 D ay 91 2 6 9 .9 289.4 3 0 1 .9 2 5 7 .0 2 7 5 .9 264.2 262.7 285.1 328.9 2 3 0 .7 2 8 7 .0 2 5 6 .0 2 4 4 .0 2 8 5 .8 2 9 9 .5 331.1 313.6 257.8 288.9 279.4 278.1 302.7 3 3 9 .7 2 7 2 .7 308.7 300.2 264.3 3 3 0 .1 299.0 348.6 296.9 2 5 4 .5 297.6 2 7 7 .4 268.3 302.8 349.8 274.0 312.3 308.7 261.5 347.9 265.2 319.4 250.2 262.2 276.3 290.8 283.4 2 3 8 .9 307.7 2 5 5 .5 2 6 8 .1 3 4 5 .7 2 7 9 .1 290.0 2 7 5 .6 309.7 3 1 1 .7 2 6 7 .9 328.2 274.3 276.7 3 3 7 .1 283.5 2 8 0 .5 280.0 323.1 313.9 269.3 336.0 2 8 5 .9 D a y 98 2 7 6 .1 2 9 8 .7 317.6 272.7 369.5 2 7 5 .1 329.2 2 8 8 .9 296.9 283.3 3 3 3 .1 303.2 2 8 0 .2 350.7 296.3 D ay 105 280.6 2 9 8 .7 324.0 2 7 1 .5 3 8 4 .6 275.2 335.1 297.0 307.9 2 9 2 .1 3 5 0 .1 307.9 2 7 5 .1 354.2 3 0 1 .9 DuPont-5386 D ay 112 2 8 4 .3 303.2 326.8 2 8 5 .8 398.5 2 7 7 .7 333.4 310.5 328.3 300.2 358.7 308.9 2 8 2 .5 3 6 8 .9 3 1 1 .8 600 Company Sanitized. Does not contain TSCA CB H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 119 D ay 126 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 286.2 308.6 3 2 5 .5 2 8 3 .6 404.8 277.7 340.7 309.7 3 2 8 .5 301.5 372.2 3 2 3 .0 2 8 0 .1 382.3 313.6 2 8 0 .8 310.4 3 3 1 .7 2 9 0 .9 4 1 1 .1 D ay 133 288.9 3 3 1 .5 343.4 2 8 9 .1 4 1 6 .6 INDIVIDUAL BODY WEIGHTS (g) D ay 140 D ay 147 D ay 154 292.1 348.6 335.9 291.3 422.0 305.5 365.2 348.0 2 9 6 .9 4 3 1 .4 318.0 373.2 357.9 2 9 7 .0 437.3 D ay 161 316.4 384.4 364.6 302.4 4 4 2 .6 D ay 168 316.7 363.1 373.9 297.6 444.5 DuPont-5386 D ay 175 3 2 2 .9 3 5 9 .2 3 7 6 .9 2 9 8 .6 4 5 0 .8 601 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 181 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 312.0 341.1 3 6 8 .9 2 8 6 .1 4 2 9 .7 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 602 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX D INDIVIDUAL FOOD CONSUMPTION 603 Company Sanitized Dees not certain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION EXPLANATORY NOTES DuPont-5386 Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed. Last day o f food consumption data collection for rats designated for reproduction evaluation. Day 83-89 Rats designated for the 3-month recovery period were temporarily housed in metabolism cages for urine and feces collection. Food consumption data was not collected for these animals during this period. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day o f food consumption data collection for animals designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day o f food consumption data collection for animals designated for the 3-month recovery period. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extrem is 604 Company Sanitized. Does notcontainTSCA CBI ^__ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) Day 7 D a y 14 M a le , I - 0 mg/k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 28.6 25.0 25.4 25.8 29.3 2 6 .5 25.0 29.4 2 7 .7 2 3 .8 2 5 .3 24.0 2 4 .1 28.4 24.3 23.3 2 6 .8 2 2 .9 22.4 2 3 .6 2 6 .0 2 2 .7 2 4 .7 28.6 26.3 29.7 2 6 .5 2 6 .5 25.2 24.4 2 8 .4 29.7 2 1 .5 23.8 2 5 .2 30.0 2 6 .6 24.3 27.3 2 6 .5 2 3 .0 2 5 .3 24.4 23.2 2 7 .7 3 1 .1 26.4 2 7 .7 2 5 .9 30.4 2 8 .6 27.4 33.6 29.4 25.4 27.2 2 2 .1 2 7 .2 2 9 .1 2 7 .0 25.8 2 7 .7 2 2 .6 2 3 .8 2 5 .7 2 5 .3 2 4 .1 27.2 3 1 .8 2 7 .9 32.6 2 7 .7 2 6 .1 26.6 2 5 .8 31.8 33.2 2 3 .0 2 3 .5 2 7 .0 32.9 2 9 .1 27.7 30.4 28.3 2 5 .5 27.0 2 3 .5 2 4 .6 2 8 .2 D ay 21 28.7 27.4 27.0 2 9 .1 3 2 .5 3 0 .5 2 5 .2 32.2 31.7 25.3 29.9 2 5 .7 30.5 31.5 2 8 .8 2 6 .2 29.0 2 4 .7 2 3 .9 2 7 .4 2 7 .0 25.0 2 7 .8 30.6 28.8 33.2 29.0 29.4 2 7 .7 2 8 .9 31.4 32.0 24.9 22.7 25.7 31.8 30.4 2 8 .5 3 1 .7 2 9 .6 2 5 .7 28.2 24.6 26.3 27.4 D ay 28 31.4 27.0 2 8 .8 2 9 .6 33.0 31.2 2 4 .6 31.7 31.2 2 6 .9 30.0 22.2 29.0 3 0 .6 2 7 .6 2 6 .5 30.9 2 4 .1 23.2 28.0 2 6 .9 24.8 28.4 3 1 .7 3 0 .5 32.1 2 8 .7 28.3 26.4 27.0 32.0 32.4 25.3 24.0 2 5 .1 31.0 29.4 2 7 .1 29.4 29.9 24.9 27.4 24.2 2 5 .5 3 0 .3 - 35 D ay 42 D ay 49 31.3 29.2 28.4 29.0 33.6 32.1 25.5 3 0 .9 3 0 .5 2 5 .8 32.3 26.4 29.3 2 9 .5 2 7 .7 26.4 30.3 2 3 .9 23.8 28.2 27.3 2 5 .1 29.2 30.4 2 9 .9 32.8 27.3 2 8 .1 2 5 .2 2 5 .3 30.8 31.9 23.9 23.8 25.2 31.6 28.7 29.2 29.6 3 2 .7 27.2 2 8 .1 2 7 .3 29.2 29.8 31.5 30.1 27.4 30.3 3 4 .6 31.2 2 4 .9 3 1 .7 31.6 2 6 .5 29.8 2 7 .1 2 9 .9 31.1 2 9 .2 2 7 .5 3 0 .0 2 4 .2 25.8 29.3 2 7 .0 2 4 .8 3 0 .1 33.1 27.5 31.6 2 7 .4 2 8 .6 2 4 .8 2 7 .3 31.3 32.4 2 4 .9 2 5 .2 27.2 31.4 2 9 .6 2 7 .7 2 9 .0 33.2 2 8 .0 2 4 .4 25.3 2 7 .2 29.9 2 9 .2 2 6 .5 2 6 .8 2 8 .4 3 0 .1 2 7 .1 25.4 28.8 30.0 28.3 30.4 2 8 .7 3 0 .7 3 2 .8 29.0 2 9 .1 32.0 2 3 .8 2 4 .5 2 7 .7 2 8 .2 2 5 .5 3 1 .2 3 4 .8 3 1 .1 34.3 29.2 31.6 2 7 .6 30.4 31.2 35.9 2 5 .9 27.3 2 7 .7 31.9 30.1 3 0 .1 29.6 32.2 27.2 2 6 .9 26.8 2 9 .4 2 7 .8 DuPont-5386 56 D ay 63 D ay 70 31.2 32.0 2 8 .6 30.8 34.6 3 1 .6 2 6 .8 33.2 3 4 .2 2 5 .1 3 0 .9 27.6 30.0 30.2 27.3 27.6 2 9 .6 2 3 .0 2 5 .1 2 6 .3 2 8 .3 2 4 .0 29.3 33.5 30.0 34.3 29.3 30.6 2 6 .5 3 1 .2 31.2 35.2 2 5 .5 2 6 .5 2 9 .5 30.3 2 9 .9, 2 8 .7 3 1 .2 3 0 .7 2 7 .0 2 4 .0 26.2 27.6 28.8 3 3 .3 3 3 .1 2 9 .4 2 8 .5 37.4 31.3 2 7 .5 34.3 3 3 .8 2 4 .7 2 3 .0 2 6 .6 2 4 .0 31.3 2 6 .5 2 6 .6 2 9 .8 2 2 .8 2 5 .6 2 8 .6 2 8 .5 2 4 .2 2 9 .8 35.0 2 9 .2 34.3 2 8 .8 30.0 2 6 .9 31.0 3 0 .8 35.0 2 6 .5 2 7 .8 2 8 .7 3 3 .1 3 0 .4 2 9 .7 3 0 .1 3 0 .4 2 8 .0 12.8 2 6 .1 2 6 .3 2 9 .9 2 9 .5 3 0 .4 2 6 .9 30.3 33.3 3 2 .5 2 7 .2 33.2 2 9 .9 2 7 .4 29.3 2 5 .4 2 6 .7 3 2 .5 2 6 .9 2 2 .9 3 0 .1 2 3 .5 2 4 .2 2 7 .1 2 7 .8 2 6 .2 2 9 .8 3 4 .2 2 8 .5 3 4 .1 2 8 .9 3 0 .0 2 6 .2 32.2 3 2 .7 3 5 .9 2 5 .9 27.3 2 9 .0 3 2 .6 3 2 .8 2 8 .7 3 0 .6 2 9 .7 2 7 .9 1 9 .9 2 6 .1 2 7 .4 2 8 .5 605 Company Sanitized. Does not contain TSCA CBI U fr H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 D ay 74 D ay 77 M a le , I - 0 mg/k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 34.0 2 8 .7 3 0 .9 32.2 26.0 2 6 .1 2 7 .7 30.6 27.0 31.2 33.4 2 8 .5 35.6 30.6 3 2 .5 3 0 .1 3 8 .5 3 3 .1 4 0 .3 2 4 .7 3 0 .2 2 8 .6 2 7 .3 30.7 32.5 2 9 .7 2 5 .9 34.2 32.8 27.3 25.2 30.3 2 6 .4 26.4 2 8 .0 28.0 30.4 32.8 2 3 .5 3 0 .1 28.4 26.3 17.3 2 5 .0 2 7 .7 D ay 84 2 9 .0 29.0 2 7 .0 30.7 33.6 2 9 .7 2 6 .3 32.5 32.2 2 6 .7 27.9 30.4 2 5 .9 24.2 26.6 2 7 .8 3 0 .1 32.0 2 4 .9 2 8 .1 28.4 2 6 .9 15.9 24.9 30.4 INDIVIDUAL POOD CONSUMPTION (g/day) D a y 90 D a y 98 D ay 105 D ay 112 D ay 119 D ay 126 D ay 133 2 8 .5 2 7 .5 2 5 .2 2 8 .3 33.1 2 5 .1 2 5 .5 32.7 31.5 22.9 21.2 27.8 2 4 .6 2 6 .9 31.1 2 7 .9 26.4 27.4 31.0 29.0 27.3 2 3 .6 3 1 .0 2 7 .6 2 6 .0 2 8 .6 17.1 2 5 .8 2 4 .6 2 7 .6 2 8 .5 2 7 .4 2 6 .1 2 7 .4 2 8 .1 2 9 .5 2 5 .0 23.8 2 7 .2 2 8 .2 29.4 29.2 25.6 2 8 .5 2 7 .6 2 4 .6 24.2 2 5 .0 28.8 24.9 27.4 26.3 3 3 .5 33.1 2 8 .7 2 9 .1 30.8 2 6 .8 25.4 27.0 2 4 .0 28.2 2 8 .6 3 2 .6 31.6 31.6 29.6 32.6 2 8 .0 12.4 26.3 2 3 .5 2 7 .8 29.9 31.4 3 2 .5 31.3 2 9 .0 32.3 2 7 .2 2 8 .2 2 8 .7 2 3 .1 27.4 2 9 .7 2 9 .5 3 2 .8 3 0 .8 2 7 .3 30.6 2 5 .4 14.4 2 6 .1 2 7 .1 2 7 .5 606 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 M a le , X - 0 mg/k g /d a y 643241 643300 643143 643205 643235 643288 643150 643189 643185 6 4 3 2 X0 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 28.3 3 3 .1 2 9 .3 2 1 .3 2 7 .7 29.2 30.7 30.2 2 6 .0 13.9 D ay 154 2 9 .9 31.7 31.4 26.8 32.4 INDIVIDUAL FOOD CONSUMPTION (g/day) 161 D ay 168 D ay 175 D ay 181 33.0 33.9 32.2 28.5 2 9 .7 30.2 3 1 .8 2 7 .5 29.2 3 4 .5 33.1 27.4 2 4 .7 28.8 2 7 .5 24.3 3 4 .7 2 8 .4 2 9 .8 23.7 DuPont-5386 607 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D ay 14 M a le , I I I - 25 mg/k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 2 9 .4 2 3 .2 23.6 25.6 2 3 .8 2 6 .7 27.2 25.0 25.4 2 6 .4 24.4 23.2 2 3 .6 2 3 .5 24.8 1 9 .1 2 9 .3 2 4 .6 2 9 .8 2 2 .1 2 6 .5 2 8 .0 2 8 .9 24.4 2 3 .6 26.3 30.2 28.2 2 7 .7 2 7 .0 26.5 2 3 .0 2 7 .3 2 8 .7 26.0 2 9 .9 2 4 .9 26.6 2 5 .6 3 0 .9 3 0 .9 2 9 .1 24.9 28.6 2 8 .1 25.4 2 7 .9 24.2 2 5 .6 26.4 2 1 .2 32.4 2 5 .4 2 9 .6 2 4 .1 27.8 29.2 3 3 .7 2 7 .7 2 6 .7 28.3 33.2 3 1 .4 2 7 .7 2 9 .6 25.6 2 3 .5 2 8 .7 2 8 .6 27.0 D ay 21 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 29.3 26.3 25.6 27.7 32.3 31.7 29.3 23.3 29.2 29.3 2 5 .4 31.1 2 4 .1 2 5 .9 27.2 2 1 .5 32.8 2 5 .7 30.4 24.2 29.2 3 1 .1 33.4 2 5 .8 26.0 31.8 3 4 .5 30.3 26.4 29.8 2 5 .2 2 2 .9 2 8 .5 28.0 2 7 .4 2 9 .9 2 6 .6 26.3 28.6 3 2 .7 31.2 2 9 .1 23.6 29.4 2 8 .7 25.0 30.9 2 4 .9 25.4 26.4 21.6 3 2 .1 2 6 .7 3 0 .3 25.5 30.2 31.9 31.6 27.6 2 7 .7 3 0 .1 35.4 3 2 .5 23.7 29.8 24.6 22.6 29.2 28.5 28.0 3 2 .8 2 8 .4 26.0 29.8 35.4 34.0 31.2 26.0 3 2 .1 2 8 .7 26.6 33.3 27.4 2 7 .1 30.4 2 3 .9 31.1 27.0 32.0 24.3 30.6 30.8 32.2 27.4 2 8 .9 32.7 34.0 32.0 19.7 29.8 26.5 24.2 2 9 .5 2 9 .4 28.6 29.0 29.0 27.2 29.2 33.6 34.9 31.7 24.4 32.4 2 8 .1 2 5 .5 33.4 2 8 .1 25.4 28.4 2 2 .9 31.6 25.3 3 1 .1 2 5 .2 3 0 .8 2 9 .0 32.3 2 5 .5 26.0 30.3 3 2 .5 30.8 2 7 .7 2 9 .3 2 7 .0 23 .2 31.2 29.3 28.3 27.4 25.3 2 4 .8 2 6 .1 30.0 2 9 .5 2 8 .6 23.4 2 7 .8 2 5 .6 2 7 .7 3 0 .1 2 2 .0 2 6 .7 2 9 .5 2 2 .9 32.7 2 5 .7 30.4 25.3 31.2 13.2 33.2 2 8 .4 25.2 3 1 .0 3 5 .2 31.9 25.0 2 9 .1 2 7 .8 2 3 .8 3 2 .1 2 9 .5 2 8 .9 D ay 56 30.7 2 9 .7 26.3 2 9 .2 3 5 .5 34.4 33.1 2 5 .1 31.4 2 8 .6 2 5 .1 33.0 25.8 26.3 30.4 2 3 .2 3 4 .0 2 5 .1 2 9 .5 2 6 .0 3 0 .5 2 8 .8 33.1 28.7 2 9 .1 31.4 35.4 32.0 2 4 .9 2 9 .2 2 7 .6 14.2 3 1 .1 2 9 .6 2 9 .2 D ay 63 29.3 2 8 .4 2 7 .8 2 9 .3 3 5 .1 32.5 3 4 .0 2 4 .1 3 0 .1 2 4 .4 23.3 30.5 25.3 2 6 .6 2 9 .9 2 3 .3 3 2 .7 2 6 .0 3 1 .5 2 5 .8 3 1 .8 2 9 .4 32.9 2 7 .7 2 9 .2 3 1 .8 3 3 .8 30.6 2 1 .5 3 0 .8 2 7 .3 2 3 .6 30.8 3 0 .2 2 9 .0 DuPont-5386 D ay 70 2 7 .1 2 8 .6 2 8 .3 2 8 .0 3 3 .3 3 5 .0 3 1 .9 2 2 .8 2 6 .1 2 7 .2 2 4 .8 33 .0 24 .3 2 7 ..4 2 8 .,8 2 3 ..2 3 2 ..1 2 5 ,.0 3 2 ,. 0 2 5 ,. 9 3 2 ,. 0 29 .0 34 .4 28 .5 29 .4 32 .2 32 .8 32 .5 22 .8 30 .6 26 .6 24 .9 30 .2 30 .2 28 .8 608 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ai 77 M a le , I I I - 25 mg/k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 22.3 3 3 .9 25.8 2 9 .7 2 5 .0 3 1 .1 33.3 32.1 30.3 2 9 .7 2 9 .9 36.2 32.8 33.6 32.0 28.8 2 7 .0 31.1 30.9 27.8 29.3 2 8 .9 27.4 2 4 .6 3 3 .0 33.4 30.8 2 2 .X 2 5 .6 2 6 .3 24.2 29.8 2 2 .9 25.3 2 7 .0 D ay 84 2 5 .0 2 9 .7 2 9 .8 26.6 33.8 32.8 30.9 23.2 2 8 .8 2 8 .6 2 4 .4 2 8 .2 24.7 26.1 26.0 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 90 D a y 98 D ay 105 D ay 112 20.5 27.9 2 9 .8 2 4 .1 3 0 .6 32.6 30.4 23.4 2 7 .7 26.0 23.2 24.6 22.5 24.8 26.7 24.0 29.3 25.3 2 6 .0 29.3 26.2 31.3 24.4 2 8 .7 2 8 .0 26.3 27.0 25.3 30.3 2 9 .7 D ay 119 2 6 .2 27.0 18.4 2 9 .0 2 8 .9 D ay 126 2 5 .9 27.4 2 5 .0 2 6 .8 2 6 .1 DuPont-5386 D ay 133 2 6 .5 3 2 .7 28.3 1 6 .2 2 8 .9 609 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 M a le , I I I - 25 mg/k g /d a y 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 2 5 .0 30.6 2 6 .9 31.4 29.6 2 6 .7 3 1 .7 2 7 .7 31.4 30.2 D ay 154 28.6 3 0 .9 2 9 .1 3 1 .9 3 2 .7 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 D ay 168 D ay 175 D ay 181 2 7 .1 2 9 .7 26.9 29.2 31.2 2 6 .9 30.6 27.5 29.7 31.3 2 7 .5 30.2 26.3 30.0 30.9 2 3 .1 27.4 23.0 25.8 25.2 DuPont-5386 610 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D ay 14 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 23.8 2 5 .9 2 6 .8 2 6 .5 2 9 .5 2 5 .9 2 8 .9 2 8 .0 2 6 .1 2 4 .1 2 2 .4 23.4 20.8 24.6 21.6 23.4 26.3 27.6 2 7 .6 29.3 26.4 2 8 .4 2 4 .9 2 2 .5 2 8 .1 2 7 .8 26.7 25.8 28.3 2 6 .9 27.3 25.5 28.4 26.3 2 8 .0 2 3 .1 30.2 2 9 .5 2 7 .7 32.3 2 8 .0 30.8 27.8 2 6 .9 2 4 .5 2 5 .5 2 7 .1 2 1 .6 2 7 .9 2 2 .8 2 5 .1 3 0 .7 29.2 28.2 31.8 2 9 .1 3 2 .7 2 7 .5 2 4 .4 2 9 .4 30.2 30.0 2 8 .9 26.4 30.1 30.3 27.3 30.0 27.4 30.0 D ay 21 2 5 .3 2 8 .7 2 7 .2 3 0 .4 2 8 .7 2 8 .5 2 9 .6 27.2 26.3 2 4 .9 26.2 27.4 2 2 .9 2 8 .1 2 4 .5 24.9 3 1 .7 29.2 27.8 31.9 29.7 33.5 2 6 .1 24.6 29.8 30.2 30.2 29.4 27.8 28.4 29.4 2 7 .9 2 9 .9 2 6 .1 2 8 .9 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 ' 25.8 28.0 2 8 .1 29.6 29.7 29.7 28.8 2 8 .7 25.4 2 6 .0 2 6 .8 28.3 2 6 .1 2 8 .9 2 4 .0 2 6 .1 32.8 30.6 27.8 35.4 30.3 33.4 2 7 .8 2 4 .2 31.2 30.9 30.9 32.3 28.5 30.1 31.5 28.3 31.6 25.9 29.3 24.4 31.3 29.5 2 9 .6 58.6 29.8 29.0 2 8 .6 2 7 .3 2 4 .8 2 7 .0 30.6 2 7 .3 2 9 .4 24.1 26.5 32.8 30.8 2 8 .1 33.0 31.3 33.6 28.2 24.8 31.5 2 9 .1 30.0 30.6 28.6 28.5 3 1 .1 2 7 .9 32.8 27.7 30.9 2 2 .9 30.0 30.1 29.1 31.8 30.2 31.0 2 8 .4 27.6 2 5 .1 26.4 2 9 .1 2 6 .6 31.6 2 3 .8 27.4 31.7 30.0 27.8 3 2 .1 30.4 33.5 2 9 .4 2 3 .8 30.0 30.3 3 1 .1 3 0 .5 2 8 .0 2 9 .5 3 2 .6 2 7 .1 31.4 2 8 .5 30.2 2 2 .9 2 8 .6 2 6 .4 25.8 15.1 2 7 .4 28.8 2 6 .7 2 4 .5 23.4 2 6 .9 2 9 .7 2 7 .9 3 1 .1 2 8 .4 2 9 .8 3 1 .9 2 9 .5 2 6 .7 3 2 .1 3 0 .9 32.9 2 9 .0 2 5 .4 30.7 30.3 32.4 31.1 31.2 31.2 31.6 2 7 .1 33.3 2 8 .9 30.2 D ay 56 2 4 .5 3 0 .8 2 7 .6 2 8 .8 2 7 .1 31.8 30.8 30.8 26.6 2 6 .1 26.9 2 9 .9 26.8 31.4 25.3 2 7 .0 32.2 30.4 2 8 .5 31.0 30.7 33.9 2 7 .1 25.3 31.4 31.6 31.3 31.0 3 0 .5 30.2 3 0 .6 2 6 .0 3 4 .5 2 9 .8 3 1 .6 DuPont-5386 D ay 63 D ay 70 2 6 .2 30.8 2 8 .8 2 9 .0 3 0 .7 2 7 .7 30.8 31.3 2 5 .6 2 6 .1 2 1 .4 2 8 .3 2 7 .6 2 7 .1 2 5 .4 2 9 .2 3 2 .5 3 0 .7 3 0 .3 2 9 .6 2 9 .5 31.3 27.2 2 7 .6 3 1 .9 3 1 .5 3 3 .7 3 2 .1 2 9 .2 35.5 30.6 2 6 .3 3 4 .1 2 8 .7 3 3 .1 '' 25 3 30 4 28 1 28 0 30 7 8 32 56 30 7 25 6 24 6 26 e 27 8 27 1 30 9 26 3 26 5 31 9 32 8 29 0 30 9 30 9 30 8 25 0 26 ,5 32 .4 31 ,0 33 ,0 33 ,7 31 .5 29 .6 32 .3 26 .4 34 .4 27 .8 29 .7 611 Company Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ay 77 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 2 5 .7 3 2 .1 2 8 .2 2 8 .5 2 8 .8 3 0 .6 2 9 .8 2 3 .5 2 2 .8 30.4 35.5 32.3 2 9 .5 2 9 .6 34.6 20.8 28.5 2 9 .1 30.6 26.4 2 3 .3 30.2 2 6 .7 26.5 2 8 .6 6 .8 32.0 3 0 .1 2 4 .6 2 4 .0 2 6 .6 2 6 .9 2 5 .1 2 9 .7 2 4 .7 D a y 84 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 90 D ay 98 D ay 105 D ay 112 23.4 27.3 27.0 25.0 2 7 .9 AK T E ST DAY 77 16.9 24.6 2 4 .5 2 4 .9 2 7 .1 20.0 2 5 .1 31.4 24.8 2 3 .6 2 7 .8 25.8 2 5 .7 2 9 .7 2 6 .8 19.5 23.7 22.5 28.1 20.5 23.7 2 4 .9 2 3 .4 31.1 26.5 21.8 23.0 24.6 2 9 .9 1 .4 24.6 31.2 2 4 .7 2 7 .7 1 8 .5 2 3 .7 32.9 22.2 D ay 119 2 2 .5 2 8 .9 20.5 31.0 2 4 .7 D ay 126 2 9 .1 3 0 .1 15.3 29.4 2 3 .6 DuPont-5386 D ay 133 . 2 7 .1 2 9 .8 2 8 .4 2 4 .6 2 6 .6 612 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 M a le , V - 100 mg/k g /d a y 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 2 7 .7 13.7 32.5 3 3 .5 2 6 .7 3 0 .6 32.3 31.4 36.3 2 8 .1 D ay 154 30.3 33.8 30.0 35.0 2 6 .9 INDIVIDUAL FOOD CONSUMPTION (g/day) 161 D ay 168 D ay 175 D sy 181 2 9 .6 3 2 .5 2 8 .0 36.4 2 7 .8 30.3 32.2 27.6 40.3 2 7 .8 2 8 .0 30.3 30.0 37.8 2 7 .2 2 4 .2 2 7 .5 26.4 3 2 .1 24.7 DuPont-5386 613 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D ay 14 M a le , V II - 250 mg/k g /d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 26.4 2 5 .9 2 5 .4 2 3 .6 2 6 .6 2 6 .6 2 6 .7 2 8 .3 2 5 .1 3 0 .8 2 3 .8 2 4 .9 2 3 .1 29.0 24.2 23.4 30.7 2 9 .5 2 5 .8 2 5 .6 3 2 .5 2 7 .7 2 5 .0 2 5 .2 26.4 2 4 .7 2 8 .4 2 8 .3 2 8 .0 2 6 .4 2 6 .1 29.2 2 4 .7 2 5 .9 2 7 .5 29.8 2 4 .7 2 4 .7 25.6 2 6 .6 2 5 .4 2 8 .1 2 0 .9 35.7 20.5 2 5 .1 27.5 26.0 24.0 2 7 .5 28.8 29.2 29.8 2 7 .7 33.0 26.3 2 8 .1 25.2 3 1 .1 2 6 .7 25.8 3 3 .5 3 1 .9 2 7 .6 27.7 34.6 2 7 .1 27.3 2 6 .5 28.6 2 6 .9 2 9 .7 27.4 2 7 .7 2 8 .6 2 9 .1 32.8 27.4 2 9 .6 2 9 .3 31.3 28.6 29.2 29.7 28.4 29.6 31.6 22.6 29.9 27.7 D ay 21 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 2 5 .6 2 6 .6 2 5 .4 2 4 .9 2 6 .9 2 9 .4 2 7 .3 2 8 .7 28.3 32.3 2 4 .8 2 6 .9 2 4 .0 31.7 2 7 .7 2 5 .7 33.1 30.5 2 4 .9 30.5 33.4 28.8 26.4 2 5 .7 2 7 .6 2 6 .9 3 0 .2 2 8 .4 29.2 2 8 .0 29.8 3 4 .7 2 7 .7 29.8 28.0 31.5 28.3 2 7 .8 2 7 .5 2 9 .1 2 7 .9 3 0 .0 2 1 .8 2 9 .9 26.2 25.6 2 9 .1 27.2 2 7 .5 2 8 .5 28.9 27.3 29.5 29.2 32.4 2 5 .6 30.0 9 .1 32.6 27.8 26.8 3 3 .6 30.3 2 7 .4 30.6 32.0 30.3 29.3 26.3 2 7 .6 27.0 2 9 .7 28.8 30.0 26.3 30.6 34.2 27.3 3 0 .7 2 9 .0 32.4 27.6 2 8 .9 26.6 29.8 2 8 .7 31.5 24.4 30.6 2 8 .1 2 5 .1 30.4 26.0 2 6 .0 2 7 .7 2 7 .6 2 7 .5 2 9 .7 3 0 .2 3 4 .1 25.3 31.6 2 0 .7 33.2 29.5 27.8 35.5 31.0 31.5 31.7 33.2 31.4 2 9 .5 28.4 28.4 29.7 30.2 29.2 3 0 .6 2 7 .2 30.3 33.5 26.3 28.8 29.2 31.0 2 7 .2 28.6 26.0 27.8 28.6 3 2 .1 2 3 .6 3 1 .3 2 8 .1 25.0 29.0 26.8 2 6 .0 2 7 .5 2 9 .6 2 7 .1 30.3 3 0 .1 35.1 24.0 32.5 25.5 32.9 29.7 2 7 .6 34.9 31.9 3 0 .7 28.8 31.3 3 0 .7 2 8 .5 2 6 .8 2 8 .3 2 8 .0 3 1 .7 2 9 .5 30.2 26.8 29.1 33.2 26.5 29.0 27.3 2 9 .5 1 2 .7 2 7 .6 2 5 .9 2 7 .6 2 7 .6 2 8 .7 22.4 2 8 .8 28.1 24.8 19.3 2 2 .6 2 1 .1 23.2 2 4 .7 24.2 2 2 .8 2 3 .4 2 6 .5 2 1 .6 2 8 .9 2 0 .8 3 2 .5 2 6 .9 2 5 .6 29.1 32.4 28.2 2 9 .0 2 9 .6 2 7 .0 27.2 2 2 .6 2 5 .9 2 6 .0 2 8 .0 2 8 .0 30.7 2 7 .2 2 7 .1 3 1 .8 2 5 .8 2 6 .1 24.7 3 0 .4 2 4 .5 2 7 .5 2 4 .5 26.4 19.8 30.0 23.0 28.8 2 6 .8 D ay 56 2 7 .5 2 3 .9 2 4 .5 22.8 2 6 .4 9 .9 2 8 .0 2 6 .5 2 3 .1 31.0 24.3 2 9 .2 2 4 .5 31.3 12.5 13.6 32.5 32.4 2 9 .5 27.4 18.4 2 7 .6 2 6 .8 2 9 .5 2 8 .2 2 4 .7 2 7 .0 29.2 30.1 2 5 .2 27.3 2 9 .1 2 5 .1 2 6 .1 26.2 30.9 28.0 2 8 .0 2 1 .8 3 0 .0 2 3 .9 2 8 .7 23.7 2 6 .0 2 8 .7 DuPont-5386 D ay 63 D ay 70 2 7 .0 3 0 .2 2 5 .2 2 6 .4 2 5 .3 23.2 2 7 .9 29.3 2 2 .6 33.4 1 9 .9 2 3 .2 2 3 .4 2 7 .4 14.5 2 3 .5 31.6 2 9 .2 2 5 .3 17.4 2 8 .9 15.8 2 4 .9 2 1 .0 2 2 .9 2 4 .3 19.8 2 2 .5 2 8 .3 2 5 .8 2 7 .5 2 6 .2 1 9 .1 2 0 .6 2 9 .8 2 8 .3 2 7 .1 2 7 .3 18.2 2 2 .2 2 1 .3 2 7 .9 2 0 .7 16.8 28.0 ' 29.9 4 .0 2 5 .8 2 7 .5 13.6 2 4 .7 2 7 .2 2 7 .4 3 0 .0 3 1 .1 1 4 .7 2 7 .4 24.4 2 8 .0 12.2 2 8 .0 12.0 2 8 .5 14.6 2 3 .0 2 3 .4 1 4 .0 20.8 2 8 .5 22.2 2 4 .6 2 3 .6 2 7 .9 26.3 2 6 .0 2 6 .4 5 .2 6 .4 6 .4 2 9 .1 4 .4 2 4 .5 2 5 .4 1 9 .6 2 6 .9 2 8 .1 2 6 .0 22.0 12.3 2 5 .8 614 Company Sanitized. Does not contain TSC CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ay 77 M a le , V II - 250 tng/k g / d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 28.8 25.4 25.9 22.8 31.8 21.0 20.0 30.8 18.9 28.8 29.1 28.5 18.6 27.9 28.8 10.1 34.3 27.4 26.7 18.7 AK TE ST DAY 70 27.8 25.3 31.6 15.5 13.5 27.6 27.7 23.2 26.7 16.9 36.4 25.3 37.4 26.2 30.2 11.6 25.6 26.9 22.3 10.4 23.8 13.9 28.0 27.3 D a y 84 INDIVIDUAL FOOD CONSUMPTION (g/day) D a y 90 D ay 98 D ay 105 D ay 112 26.9 29.5 24.7 26.9 29.1 28.5 27.0 29.0 26.7 27.4 23.0 25.8 20.8 31.4 22.0 27.4 29.9 24.1 21.0 28.8 27.8 23.9 26.7 26.1 27.8 24.5 20.5 18.8 26.4 24.3 24.2 25.5 20.7 30.3 23.4 25.4 23.3 19.4 31.5 25.0 18.9 24.0 19.6 31.7 23.9 26.6 32.4 27.2 26.1 22.9 31.0 31.7 26.5 18.1 29.6 26.0 31.3 26.9 24.0 22.6 29.5 30.0 27.4 20.1 17.5 26.3 30.3 25.1 26.5 22.5 23.5 27.2 27.5 21.1 26.7 27.4 31.3 26.6 29.9 21.0 25.5 25.3 25.1 21.9 25.8 26.7 30.5 23.5 27.8 21.6 27.7 24.8 25.7 20.4 23.1 D ay 119 20.5 24.7 19.5 32.4 22.9 26.8 29.5 23.7 27.3 24.6 24.6 26.7 27.8 23.6 25.8 D ay 126 23.1 26.2 20.7 31.5 24.2 DuPont-5386 D ay 133 , 23.0 27.3 21.3 32.0 25.4 615 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 M a le , V II - 250 mg/k g /d a y 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 27.0 28.8 24.6 29.9 24.3 28.9 31.0 24.1 31.0 28.8 D ay 154 INDIVIDUAL POOD CONSUMPTION (g/day) D ay 161 D ay 168 D ay 175 D ay 181 30.5 30.5 24.6 32.4 29.4 30.6 30.5 25.4 35,9 31.0 31.6 31.5 25.7 34.9 30.7 29.2 29.9 23.7 33.1 28.5 25.9 25.8 20.8 31.1 22.8 DuPont-5386 616 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D ay 14 F e m a l e , I I - 0 mg/kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 18.9 19.8 17.0 14.8 18.3 18.9 16.4 18.7 18.9 15.9 15.4 17.5 17.2 16.8 16.6 18.7 17.3 17.7 20.2 18.6 18.5 17.3 20.0 17.5 18.1 19.8 22.2 19.8 14.6 17.7 21.2 20.7 1 8 .9' 18.4 18.5 22.0 20.1 22.6 19.1 21.8 19.3 21.4 18.8 19.2 18.8 18.5 19.6 17.7 13 . 4 18.9 20.7 18.2 18.9 19.8 16.5 20.5 17.1 20.7 16.9 19.0 20.7 19.8 20.2 20.6 21.4 19.5 18.0 22.0 22.0 19.4 22.1 23.4 22.7 17.8 18.8 23.5 22.8 20.9 19.7 19.1 24.7 22.0 20.9 19.9 24.0 22.2 18.7 21.6 19.9 18.9 D ay 21 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 19.8 18.3 17.2 15.8 22.3 21.0 18.0 18.6 20.5 18.4 19.0 18.9 20.2 17.9 17.8 21.0 19.5 18.8 19.4 20.8 20.9 12.8 20.6 20.7 18.8 24.7 24.2 21.8 16.7 18.9 22.2 22.5 19.5 18.9 17.7 22.9 21.1 19.6 20.9 22.4 21.4 19.5 22.1 21.2 19.8 18.8 18.0 19.0 14.4 20.1 20.8 18.1 22.3 19.2 16.7 20.3 16.6 19.2 15.3 17.7 20.7 19.1 19.4 18.7 20.0 21.0 17.5 22.6 19.3 17.4 22.2 22.3 19.7 18.0 18.2 20.6 24.6 20.3 16.5 17.1 23.9 21.1 19.5 20.2 24.2 21.0 18.8 22.2 22.4 19.8 21.9 18.5 19.1 15.9 21.5 21.7 20.9 21.3 20.9 17.8 22.2 19.8 20.3 17.9 21.4 22.2 22.3 21.5 21.0 21.7 22.9 18.6 22.7 19.4 18.8 27.6 25.7 22.5 17.9 17.7 22.3 23.4 22.0 17.4 17.4 24.7 19.5 20.7 22.1 22.1 21.8 21.3 21.8 23.4 21.2 20.4 21.9 18.4 17.0 19.8 19.9 18.2 18.4 22.0 19.4 23.0 20.4 19.9 15.6 17.1 20.3 19.8 22.8 18.7 19.7 21.0 18.9 21.4 20.0 20.5 25.9 24.8 22.5 16.9 18.9 21.3 22.6 21.8 17.6 17.5 24.7 21.5 20.8 20.0 21.4 21.1 19.3 21.1 23.1 20.3 18.5 18.2 18.0 16.7 26.1 19.4 18.8 17.6 19.1 20.4 25.2 22.6 21.7 18.1 19.3 21.1 21.1 22.1 21.1 20.7 20.9 18.8 21.9 21.3 18.8 27.2 24.9 23.3 19.3 18.2 22.6 22.7 21.2 18.4 18.5 24.1 20.2 19.7 20.2 20.7 20.8 19.2 21.2 24.0 20.3 D ay 56 18.8 20.1 19.8 20.5 24.4 23.8 22.1 21.4 21.5 21.2 23.1 24.4 22.0 16.9 18.8 20.0 20.5 19.6 17.0 20.7 21.9 20.5 24.7 19.1 20.3 24.2 23.9 22.7 19.9 18.0 20.2 24.0 21.1 17.6 18.5 24.0 20.6 22.5 20.6 21.6 20.5 19.6 20.0 23.5 21.7 DuPont-5386 D ay 63 D ay 70 20.6 22.4 20.6 19.2 24.9 22.7 21.3 18.8 21.9 20.9 20.8 21.9 20.9 17.2 19.8 20.3 16.8 20.1 19.8 20.0 20.6 20.4 22.8 19.0 19.0 24.9 23.3 23.5 18.2 19.2 21.9 22.0 22.7 18.3 19.0 22.0 21.3 23.8 21.3 26.3 21.0 19.9 21.2 22.8 22.8 18.6 22.4 19.2 19.5 24.5 21.5 21.8 20.7 21.0 18.7 22.1 23.6 22.3 18.5 18.9 20.0 19.8 21.1 18.7 20.3 21.4 19.1 21.9 18.8 19.7 22.2 21.2 23.1 18.3 18.5 21.3 23.1 20.3 17.5 18.3 22.8 20.8 20.0 22.9 30.2 20.7 20.3 22.3 22.7 21.5 617 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ay 77 F e m a le , XI - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 23.4 19.2 21.4 19.0 23.3 22.5 19.8 22.1 23.2 20.5 24.4 24.5 23.9 21.1 19.4 24.5 23.3 23.5 19.8 19.2 17.7 24.2 18.6 16.6 25.0 23.1 23.2 21.0 21.0 20.2 20.5 25.5 20.9 19.0 19.5 20.8 20.8 20.7 21.5 27.8 18.7 19.2 18.7 22.3 21.7 D a y 84 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 91 D a y 98 D ay 105 D ay 112 D ay 119 19.2 20.2 33.5 16.2 24.9 21.3 22.7 21.8 20.7 19.9 21.7 21.1 21.2 16.0 18.6 20.0 22.2 18.5 13.3 24.4 19.7 20.4 21.9 19.3 19.9 20.3 20.3 18.5 16.4 16.6 21.0 17.7 21.1 16.2 18.7 20.4 10.7 20.5 18.1 17.5 21.0 18.9 17.5 17.3 18.4 20.8 19.9 16.5 17.2 15.9 21.0 19.8 22.3 22.5 29.5 19.9 19.3 21.6 20.3 19.3 1 21.9 18.6 17.3 18.5 25.4 18.5 7.9 19.2 20.2 19.7 21.4 19.4 25.2 19.6 27.1 21.1 14.2 20.3 22.7 20.1 21.9 23.9 24.3 22.3 27.0 20.8 22.9 15.8 26.8 23.2 21.5 22.5 25.1 24.9 22.7 21.2 23.1 24.1 27.8 27.0 21.3 22.3 22.5 21.2 SE TE ST DAY 105 22.5 20.9 22.6 25.0 D ay 126 21.0 21.3 19.7 19.0 15.9 DuPont-5386 D ay 133 23.9 22.1 20.7 19.3 20.1 618 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________ _ D ay 140 D ay 147 F e m a le , I I - 0 mg/k g /d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 21.9 23.1 18.9 17.9 18.9 23.2 23.7 21.9 20.7 19.8 D ay 154 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 161 D ay 168 D ay 175 D ay 181 24.1 26.9 24.8 19.7 20.7 25.3 27.1 23.6 23.0 21.9 23.2 27.8 22.8 19.8 19.0 22.0 22.2 21.9 18.7 19.6 21.3 19.3 20.6 15.7 18.7 DuPont-5386 619 Company Sanitized- Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D ay 14 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 15.8 20.6 18.6 19.3 19.1 19.1 15.4 17.2 15.9 16.2 17.6 AK TE ST DAY 0 19.0 17.1 16.0 16.8 15.5 18.7 17.2 18.4 20.0 18.0 21.9 16.9 22.2 18.6 18.1 17.6 21.2 18.8 22.9 17.7 17.3 17.7 39.0 16.4 22.0 23.1 20.0 18.4 18.1 14.7 17.8 16.3 17.9 17.1 20.1 18.3 17.4 20.2 17.4 19.0 18.7 20.3 21.7 18.9 22.0 17.5 18.7 20.1 19.6 18.3 23.2 21.4 19.9 20.1 17.3 19.0 39.6 D ay 21 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 18.0 23.6 21.2 23.8 18.9 21.5 18.4 19.4 17.6 18.7 17.9 21.7 18.8 18.7 19.9 18.8 19.6 18.7 20.9 20.2 20.7 23.6 17.5 22.5 22.0 21.7 19.0 24.0 23.5 19.5 21.3 18.9 19.9 40.0 17.5 20.6 22.3 23.2 17.9 21.0 17.0 19.3 16.8 18.9 17.2 20.2 18.5 17.9 19.9 18.0 20.6 21.1 21.3 21.4 22.5 24.6 19.4 22.2 21.8 18.2 17.9 24.1 23.2 20.0 19.7 18.5 17.9 39.9 18.6 20.4 23.8 21.5 23.1 22.0 22.2 22.7 20.0 21.7 21.5 22.8 SE T E ST DAY 29 21.0 19.9 19.3 18.7 20.8 20.6 20.1 19.0 20.3 18.3 18.8 21.7 19.2 21.4 20.1 21.7 20.9 20.9 28.4 20.1 21.7 20.7 19.2 18.3 22.2 22.7 21.0 20.2 19.2 18.0 37.4 20.5 21.2 18.9 20.2 18.4 22.2 17.8 22.0 22.1 23.3 27.8 19.8 22.8 21.1 20.9 18.3 22.9 21.5 22.7 20.9 19.1 18.4 36.7 19.5 20.4 23.0 19.7 19.3 21.7 21.7 18.0 18.0 19.6 22.0 19.6 18.1 20.5 17.6 20.2 21.9 21.4 20.9 19.3 26.1 20.7 24.7 22.0 22.5 18.5 24.2 21.8 23.1 8.3 20.1 18.2 38.6 D ay 56 20.0 23.3 25.7 22.5 12.6 21.6 20.7 23.6 19.8 19.1 20.7 19.7 26.0 19.9 18.4 19.8 18.5 20.0 21.5 18.1 23.3 17.7 23.9 22.1 20.0 18.6 24.3 21.1 19.2 22.9 19.9 18.6 38.3 DuPont-5386 D ay 63 D a y 70 21.0 23.7 23.4 21.7 17.7 21.7 21.1 20.7 21.3 20.5 22.0 20.4 19.6 18.8 18.7 20.3 19.0 20.3 21.8 18.1 22.6 19.5 24.7 23.7 18.9 18.0 23.0 22.4 21.9 21.1 20.9 19.7 20.3 . 20.2 28.7 24.2 21.9 20.5 20.4 21.3 21.4 20.9 18.9 20.9 20.1 19.3 20.5 17.3 17.5 19.8 19.6 20.7 19.2 21.6 18.2 23.5 20.7 18.3 16.6 22.2 20.9 20.4 20.3 18.0 18.6 18.5 620 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ay 77 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643411 643483 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 21.1 19.8 19.6 21.0 21.0 23.0 18.4 21.9 20.3 24.9 25.5 8.8 19.8 25.9 22.6 26.8 22.5 21.9 21.5 20.0 20.5 28.5 22.6 21.2 18.6 21.1 22.1 21.5 20.3 17.9 19.1 19.7 18.1 D ay 84 20.0 29.1 24.4 21.6 16.4 20.4 21.6 19.6 20.3 19.5 18.9 20.0 18.5 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 91 D ay 98 D ay 105 D ay 112 17.0 23.8 21.5 20.0 16.0 18.8 19.8 21.6 18.3 18.2 17.7 18.6 15.6 18.7 21.4 18.5 17.5 18.6 21.2 20.6 19.7 19.0 22.5 21.5 19.9 D ay 119 19.8 22.0 20.9 18.8 D ay 126 19.8 22.5 21.7 18.5 DuPont-5386 D ay 133 18.7 22.7 20.9 19.3 621 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 140 D ay 147 F e m a le , IV - 25 mg/k g /d a y 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643411 643483 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 20.0 23.4 22.5 22.1 22.5 24.0 21.2 21.2 D ay 154 22.2 24.4 23.6 22.1 D ay 161 20.9 23.7 20.6 20.0 D ay 168 20.8 23.6 22.0 20.5 D ay 175 21.2 23.9 21.6 17.7 D ay 181 16.7 20.3 18.4 17.4 DuPont-5386 622 Company Sanitized. Does not contain TSCA CBI H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D a y 14 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 18.6 17.5 16.1 18.9 18.5 21.7 17.7 13.5 16.4 16.9 17.1 16.0 17.4 15.1 17.7 18.3 18.6 20.4 17.8 17.8 17.0 17.9 18.1 21.5 17.9 17.7 17.8 17.1 18.5 18.0 17.9 18.0 20.3 18.6 19.7 18.9 16.7 17.4 19.1 19.5 21.7 18.9 15.5 16.1 18.1 18.6 16.5 17.4 16.1 17.2 19.1 20.0 21.5 19.4 18.5 18.9 19.5 17.3 20.9 19.9 19.9 16.7 17.0 18.3 20.0 17.7 18.5 19.6 18.1 19.7 D ay 21 19.1 18.9 17.8 20.0 20.9 22.2 19.3 16.0 16.7 19.8 20.5 19.8 19.5 17.7 20.5 21.2 22.7 20.2 19.9 19.3 19.7 19.0 19.3 22.9 21.3 23.7 17.9 18.4 20.2 20.4 19.6 19.4 20.6 19.8 20.7 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 19.7 17.5 17.1 21.6 21.9 22.3 19.5 17.4 18.1 21.3 19.3 6.6 19.1 16.8 21.5 23.0 21.2 22.3 19.3 19.7 18.3 21.6 19.4 24.3 22.2 22.2 20.1 18.7 19.9 21.0 19.1 21.4 20.4 18.2 20.9 19.6 19.0 18.9 21.8 19.4 23.1 17.9 17.2 16.6 19.1 18.0 9.7 18.8 15.8 20.2 22.2 19.9 22.8 18.2 21.3 19.2 21.2 18.6 18.2 19.8 21.7 18.1 19.5 20.3 20.7 19.4 19.8 20.6 18.9 21.2 17.9 17.4 16.7 21.8 18.8 20.2 18.1 17.4 17.6 20.1 17.0 10.5 18.5 17.6 19.1 21.7 20.1 20.3 19.3 20.0 18.5 20.3 19.3 7.0 19.2 19.1 19.1 18.6 18.7 19.9 18.3 19.0 21.4 17.2 19.8 16.3 21.4 18.1 19.8 18.6 16.5 17.0 14.6 16.5 17.9 18.9 17.1 18.9 19.9 21.8 22.2 19.8 21.6 19.5 22.9 19.8 21.7 19.2 25.2 21.0 23.4 20.6 20.2 19.5 21.9 22.0 21.6 24.1 19.0 22.7 D ay 56 19.3 22.7 17.4 21.9 22.5 21.9 18.9 16.9 19.0 21.0 21.1 22.7 19.1 18.7 19.3 23.3 20.7 20.0 18.8 21.1 19.3 21.6 19.1 19.9 21.2 24.2 20.2 20.9 19.7 20.3 19.8 20.2 23.4 19.3 21.1 D ay 63 20.3 20.6 19.4 21.8 19.8 20.4 19.6 17.0 18.2 20.8 20.5 12.1 17.2 16.2 21.3 20.5 18.7 20.2 18.0 21.1 18.0 23.4 18.0 22.4 18.9 20.8 18.1 20.2 18.0 22.4 17.6 19.8 21.2 20.0 20.7 DuPont-5386 D ay 70 . 18.0 23 .2 18.9 22.0 20.3 16.1 19.2 17.5 18.0 21.8 20.6 21.0 18.0 19.7 20.4 21.9 19.5 19.8 17.1 21.5 19.6 21.4 18.8 24.5 18.5 20.8 17.4 19.6 18.4 21.8 17.4 19.0 22.5 19.7 19.4 623 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D a y 77 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 21.0 20.9 18.9 17.6 21.2 21.1 23.8 19.2 9.8 19.1 22.3 20.5 21.2 19.2 24.2 21.4 20.3 22.2 20.2 20.9 18.5 20.5 18.6 22.7 19.6 18.4 17.2 17.8 17.4 20.1 20.8 16.5 19.5 16.9 23.9 D a y 84 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 91 D ay 98 D ay 105 D ay 112 18.2 19.1 17.3 20.5 21.5 15.5 18.9 17.4 17.3 19.8 22.2 17.9 19.9 17.7 20.4 16.6 20.9 16.7 19.3 21.0 18.8 17.9 14.5 15.3 15.4 17.1 15.7 17.6 15.0 18.1 17.7 18.2 17.0 14.2 18.1 19.3 15.3 19.5 17.8 19.3 20.9 16.4 20.2 10.1 21.8 D ay 119 20.9 7.4 20.6 15.5 20.3 D ay 126 20.1 23.4 19.5 16.8 23.2 DuPont-5386 D ay 133 19.2 19.0 22.5 18.2 22.6 624 Company Sanitized. Does not contain TSCA CSS H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 F e m a le , V I - 100 mg/k g /d a y 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 22.6 30.7 20.0 18.5 22.2 22.4 29.3 23.0 21.0 26.6 D ay 154 21.0 18.4 23.6 20.4 23.2 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 161 D ay 168 D ay 175 D ay 181 22.9 25.6 21.3 18.4 24.9 22.8 20.5 21.1 18.0 24.2 21.7 18.0 20.7 18.8 25.8 18.4 32.5 19.0 19.2 23.7 DuPont-5386 625 Company Sanitized. Does not contain TSCA CB! H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 D a y 14 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 17.5 21.3 17.7 16.7 15.8 15.8 15.6 18.1 16.7 16.7 16.3 16.8 17.6 15.4 19.7 20.0 15.1 19.9 17.3 18.2 18.9 17.2 19.6 16.5 18.5 18.0 19.0 22.3 21.4 20.8 17.2 18.4 19.3 17.9 17.6 16.0 20.9 17.1 19.2 14.9 18.6 17.9 16.7 20.1 17.9 18.2 22.6 19.1 20.0 16.9 18.3 17.9 20.4 19.0 19.7 17.0 18.2 18.5 20.9 18.2 23.3 21.2 21.1 18.9 18.6 20.0 19.0 21.3 19.0 19.2 18.4 19.4 23.3 22.5 19.8 18.2 18.8 22.0 19.7 18.9 17.7 20.9 17.6 18.8 18.3 18.5 18.5 17.4 19.2 18.0 D ay 21 19.0 25.9 20.3 19.1 19.1 18.1 18.3 20.3 19.0 19.3 17.8 19.0 18.1 19.6 23.2 20.6 17.0 20.4 19.5 19.6 22.5 22.3 25.4 22.0 21.6 19.7 22.4 26.2 23.9 22.4 22.1 22.0 24.4 21.9 21.4 16.2 23.3 17.8 21.6 19.4 22.1 21.5 17.8 20.9 21.5 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 28 D ay 35 D ay 42 D ay 49 17.6 23.3 19.5 17.7 20.4 17.9 20.0 20.4 21.4 20.3 17.9 18.5 20.1 19.9 21.5 21.5 17.8 20.6 19.7 19.2 21.8 19.0 21.2 19.4 19.4 20.2 20.8 26.8 25.7 21.9 20.4 18.7 23.0 20.5 17.9 17.3 20.5 18.4 18.5 18.5 19.4 20.6 16.4 18.6 18.7 18.9 24.3 19.2 17.2 19.2 20.3 20.5 19.9 20.9 21.6 17.7 17.8 22.3 19.6 23.3 22.9 18.6 19.7 19.6 19.5 23.2 19.3 22.1 20.6 21.5 19.0 21.6 26.6 25.1 24.2 20.5 20.3 22.9 21.8 21.1 17.9 22.9 17.7 20.2 18.2 18.4 21.2 17.8 19.7 19.3 18.0 23.8 17.4 18.2 20.1 18.8 17.9 20.7 18.7 19.8 17.4 14.9 22.4 19.7 21.6 22.7 16.6 20.4 18.7 19.3 21.6 17.9 20.2 18.8 22.1 19.1 19.2 24.2 24.6 20.1 19.5 18.4 20.1 20.4 18.7 16.7 21.0 16.5 20.7 16.2 17.7 22.5 17.5 20.2 19.9 17.6 23.1 17.7 16.6 17.4 15.3 16.8 20.3 20.0 21.3 16.1 17.2 23.6 14.5 21.3 21.0 18.3 21.6 20.3 20.3 22.5 19.2 19.8 20.8 22.0 10.2 19.1 25.8 22.7 21.6 18.4 20.2 21.4 20.5 22.2 18.4 15.6 6.8 16.9 18.1 18.9 22.9 17.3 19.8 19.0 D ay 56 D ay 63 18.5 19.0 20.6 15.8 21.0 19.0 17.5 18.1 21.3 19.8 17.3 15.2 21.6 19.7 19.3 15.7 21.5 22.3 24.5 12.4 18.7 15.8 19.5 32.8 20.2 22.4 2.5 19.4 23.8 21.6 21.3 15.4 18.2 16.2 22.7 17.7 20.1 19.1 21.1 19.1 23.2 19.0 17.3 14.6 16.1 6.4 21.5 18.4 22.8 19.9 AK T E ST DAY 53 19.8 12.8 26.8 25.7 24.6 21.9 17.0 13.3 19.3 12.6 22.2 21.4 22.0 18.9 19.2 18.8 21.0 19.8 18.9 18.0 7.3 21.9 12.3 20.5 11.4 19.5 17.5 10.3 18.8 21.2 24.7 11.4 18.9 17.6 16.1 10.5 19.4 18.5 DuPont-5386 D ay 70 18.7 11.0 18.7 17.2 18.5 19.6 18.9 19.2 21.3 FD T E S T DAY 69 12.6 18.6 20.9 17.0 21.0 9.7 14.7 15.4 18.5 18.1 13.0 1.8 1.9 10.2 12.1 26.8 24.7 19.4 17.7 18.9 19.5 18.0 10.0 15.4 17.1 25.8 16.6 17.3 21.8 17.9 9.7 16.8 16.4 19.4 626 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 74 D ay 77 F e m a le , V I I I - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 6.8 9.5 18.2 20.6 20.0 16.3 25.5 28.3 22.6 40.1 52.1 26.2 14.4 13.1 8.4 21.0 18.2 20.6 4.0 15.8 15.4 17.8 17.4 16.3 16.2 14.8 18.9 23.6 12.9 15.5 10.6 16.8 5.1 19.1 20.3 12.2 17.7 20.9 19.1 17.4 13.4 26.3 14.8 D ay 84 21.6 29.2 20.1 16.9 19.8 24.6 25.3 22.9 23.4 19.7 22.1 23.1 20.9 24.3 21.4 24.2 23.3 23.3 17.3 22.1 29.2 21.3 25.3 21.3 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 91 D a y 98 D ay 105 D ay 112 18.4 25.7 14.0 14.1 16.9 18.5 15.5 18.9 24.4 16.6 17.7 20.4 17.1 24.3 16.9 15.6 19.9 17.6 26.9 17.0 14.8 21.1 17.1 27.2 16.8 14.8 17.4 20.1 25.8 18.1 18.1 18.0 18.0 16.1 20.7 20.2 16.8 23.4 18.1 24.7 19.1 18.3 20.7 16.4 21.0 16.7 16.8 24.3 20.4 24.2 18.7 18.5 21.4 18.8 23.1 20.0 16.4 26.2 20.4 20.4 17.6 18.3 20.9 17.8 20.1 18.3 16.9 22.1 19.2 D ay 119 16.9 16.4 18.6 18.5 24.0 12.1 19.1 19.0 22.9 17.3 23.0 21.0 17.3 22.3 20.2 D ay 126 16.2 17.4 18.0 18.2 22.9 DuPont-5386 D ay 133 , 15.8 19.6 18.9 16.4 21.0 627 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D ay 140 D ay 147 F e m a le , V III - 250 mg/k g /d a y 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 17.4 24.5 17.1 21.6 21.3 19.7 25.2 19.9 22.8 23.7 D ay 154 21.3 25.7 21.5 20.1 26.0 INDIVIDUAL FOOD CONSUMPTION (g/day) D ay 161 D ay 168 D ay 175 D ay 181 20.1 26.5 21.1 21.3 23.8 20.4 22.4 22.6 20.9 24.9 19.5 18.4 22.7 19.3 23.3 19.0 19.4 18.5 18.3 22.0 DuPont-5386 628 Company Sanitized. Does not contain TSCA CBI