Document aQ1NwmjDvYzgM8gg5VxR3bXM

_____ i-i L~ fir f. Y, (' SPECIAL PROGRAMS NEWSLETTER CHEMICAL MANUFACTURERS ASSOCIATION 350 1 M STREET, NW WASHIIMGTON. OC 20037 202/087-1100 Volume 2, No, 3 September 1985 SPPC DEBUTS AND PANELS TALK Introducing SPPC. (Yes, another acronym ... we pronounce this one spi-pik.) SPPC is the Special Programs Policy Committee -- a committee appointed by the CMA Board of Directors to oversee Special Programs. Members of SPPC include board members Harry Corless of ICI Americas, Inc. (Chairman) and Keith McKennon of Dow Chemical Company (Vice Chairman). CMA vice presidents Dr. Geraldine Cox, Gary Herrman and David Zoll complete the Committee, SPPC's purpose is to review CMA policies for the operation of Special Programs, and to recommend necessary policy changes to the Board. Unlike earlier advisory committees -- SPAC and SPAG -- SPPC will not routinely review the activities of individual programs. SPPC met with five panel leaders on June 14, 1985 to discuss the Panel members' views on operations issues. The leaders included: Wiley Barton, Dow Chemical USA (Chairman, Phosgene Panel); Dr. Gordon Diprose, Imperial Chemical Industries, Ltd. (Vice Chairman, Fluorocarbon Panel); James Quance, Exxon Chemical Americas (Chairman, Phthalate Esters Panel); Dr. Thomas Robinson, Vulcan Chemicals (Chairman, Ethylene Dichloride Panel); and Dr. Richard Ward, E. I. du Pont de Nemours & Co. (Chairman," Fluorocarbon Panel). The meeting was a further initiative toward increased communication, promoting awareness IN THIS ISSUE SPPC Debuts and Panels Talk . . i Consistency and Communication -- Who Cares? ........................ ...And Now, RCRA1 ........................ Allyl Chloride Panel Sunsets . 5 Is Your Chemical Used In Pesticides? ........................ News Briefs ............................. Research News ......................... . 8 People ................................................ Recent Releases Blister Notices' , 9 - V Special %Programs ConnfientH . .10 Research ^Reports................. Upcoming;, Events . * - . . .11 zzr,--u , :::zj of Special Programs* on several levels -- by othe? committees- bf-'CMA; and by the ,, Board. ..Topics %f-- discussion include coordination between- special Program^ and standing committees on advocacy issues,, methods of * Increasing participation by foreign 'companies, and OLI 3593 increasing panel efficiency through computerization. Dr. Langley Spurlock, Director of the Special Programs Division and Staff Executive for SPPC, sees meetings of -this type as, "an exciting new development.11 According to Spurlock, "This is the first year that Panels have had direct commu nication with each other. It began with the tri-panel meeting between the Phthalate Esters, Ethylhexanoic Acid and Trimellitates Panels earlier this year, and has continued suc cessfully with the SPPC meeting." To further aid the process of inter panel communications SPPC is en dorsing a new ^ activity for panel chairmen -- the Special Programs Leadership Sessions. Under the auspices of Gary Sunshine of ICI Americas, Inc. (former Chairman of the Special Programs Advisory Committee), a pilot session will be held at CMA onr$6ptfember T9. ' The first Session will be multi faceted. Included on the agenda will be a comprehensive, compact over view of CMA -- emphasizing how it functions as a cohesive whole. The relationship of panels to standing committees will be the topic of a discussion led by Dr. Robert Brothers of Eastman Kodak Company (Chairman of the - Hydroquinone Panel, and member - of the CMA Health and Safety Committee). Part of the Session will be devoted to the topic of improving meeting effective ness. This topic, led by Russell McBride, Director of Professional Development and Training at ICI Americas, is designed to aid the chairmen in becoming more sensitive to the unique dynamics of Panel meetings. The purpose of the Leadership^ Sessions is threefold -- to increase participants' understanding of CMA, to facilitate discussion of problems ' kfid successes in creating effective meeting dynamics, and (most impor tantly) to create a stronger link in communication between Panels. The first Session will be experimental. Based upon comments and input from the initial group of seven participating chairmen, the content will be revised and offered again. The Special Pro grams Division plans to offer these sessions periodically to allow all Panel and Task Group chairmen to partici pate. E. Moran/S, Sarver CONSISTENCY AND COMMUNICATION -- WHO CARES? The CMA Executive Committee recently approved a new statement of Operating Principles for Special Programs and a revision of the Special Programs Guidelines. (These documents are highlighted in the box on the next page.) By these approvals, the CMA Board of Directors has reiterated its position that each panel's activities must be consistent with the policies and procedures of standing committees and other panels. Intra-association communication and oversight there fore remain crucial in operation of all programs. Why bother? First, a Panel may face an issue for a specific chemical on which a standing committee has a history of negotiation with an agen cy . The benefits to the Panel of established agency contacts and technical advice from committee members are obvious. Second, a panel and a standing committee may encounter an issue at the same time -- for example the introduction of water quality testing into test rules for priority pollu tants. In this case a joint work group such as that recently estab lished by the Phthalate Esters Panel, the Environmental Manage ment Committee and the Health and Safety Committee may be the means of mutually addressing the issue. OLI 3594 I 3 Third, several panels may face the same issues simultaneously -- such as changes in EPA interpre tation of test rules -- sometimes before a standing committee has had the opportunity to establish a position. In this case the panels can provide an "early warning" to the standing committee. and influence, in fact, rely on consistent messages. Conflicting positions coming from within the Association would be self-defeating. To outsiders, CM A is not a col lection of member companies, panels, and committees -- but is the voice of the industry as a whole i Finally, one panel may begin an activity that another panel has had extensive experience with. The sharing of experience by the panels is clearly beneficial and probably economical. In every instance, panels and committees should be current on each other's positions and actions so that the Association can speak with one voice. CMA's credibility To anyone directly involved with Special Programs, the benefits of consistency and communication should be obvious from the outset. With the publication of the new Operating, Principles and Guidelines, however, now seems an appropriate time to give fresh thought to our commitment to unified action. S. Sarver ***** i; i i ; ************************************t********************************** * PRINCIPAL GUIDANCE STATEMENTS FOR SPECIAL PROGRAMS * ** * Both of these documents are essential reading for anyone involved in * Special Programs, and are available upon request. * * * * * ** * SPECIAL PROGRAMS OPERATING PRINCIPLES * SPECIAL PROGRAMS GUIDELINES ** * * * The Principles present the * general statement of policies and * procedures for operation of all * Special Programs. They address: * * The Guidelines provide details * * of policies and procedures that * * are generally stated in the * * Operating Principles, This * * document is the primary reference * * . Program Authorization * . Participant Financial Obliga * tions * . Policy Coordination * . Research Output * * * * * * * * for specific operations of special * * programs and the Special Programs * * Division. Topics covered include: * ** * . Program Initiation Procedures * . Membership Criteria * * * . Responsibilities of Panel * * i- and Task Group Participants * * , Financial Administration * * and Budgeting * . Contracting Procedures * * * . Information Handling * * * . Oversight Mechanisms * * ** ******************************************************************************** OLI 3595 AND NOW, RCRA! In November 1985, EPA intends to propose its first major rulemaking under the 1984 Resource Conser vation and Recovery Act amendments the Land Disposal Prohibition Rule. The proposal will be in two parts: 1) a land disposal ban decision rule; and, 2) the applica tion of the decision rule to some wastes containing solvents and dioxin-contaminated substances. The decision rule part permits EPA to determine whether selected haz ardous wastes are safe for land disposal. The wastes that will be reviewed by this rule are included in the RCRA Appendix VII List. This list consists of selected "F" and 11K" list wastes. (See June 1985 Newslet ter. ) EPA says it will develop a fate and effects model for groundwater con tamination, calculate Acceptable Daily Intake concentrations for all Appen dix VII substances, and propose a methodology for determination of all future ADIs. If the waste or sub stance exceeds the ADI concen tration, the waste will be banned from land disposal. The impact of this rulemaking goes beyond the specific decisions on individual wastes. Both the ADI methodology and fate and effects model will be used for RCRA listing and delisting decisions, future land disposal bans and "How Clean is Clean" decisions under Superfund. The ADIs will also be used to develop drinking water standards under the Safe Drinking Water Act. As part of the specific decisions for solvents and dioxin-contaminated chemicals, EPA will develop ADIs for 20 RCRA Appendix VII List constitu ents (F001-F005 and F020-F027). Within the next few years the remain ing wastes on this list will be reviewed by EPA for possible land disposal prohibition. The Agency will apply the fate and effects model to determine whether land disposal is safe and will specify the hazardous nature of the wastes. EPA is required to finalize decisions on each of these wastes by November 1986. If the Agency fails to do so, the wastes will be automatically banned from land disposal. What is CMA doing? Because EPA will only have a 60-day comment period on the rulemaking, the Environmental Management Committee began planning efforts for response several months ago. The EMC RCRA Regulations Task Group was designated to respond to the generic issues of the rulemaking. The Task Group has requested that appropriate Special Programs provide chemical-specific examples to illustrate and strengthen the CMA comments. The Special Programs that will be immediately affected are: Cresols, Benzene, Ketones, and Dibenzofurans. What should you do? Reviewing the Appendix VII List is a good start. If any wastes handled by your company are on the list, you should determine what would happen if that waste were banned from land disposal. Next, you should review the chemical specific background information that EPA is considering in the proposal (heaith data, fate model, and treatment tech nology) . Your company may choose to file comments. In addition, if you are a member of an affected Special Pro gram, you may decide to comment through the Panel. If your company is not a member of a Special Program, you may consider joining a Program, or forming a new program if no indus try group exists. OLI 3596 This upcoming EPA proposal is very important to the industry at large. Prepare early for the November Federal Register notice. For further details, call Robert R. Romano of the Special Pro grams Division at (202) 887-1198, R. Romano/J. Matey ALLYL CHLORIDE PANEL SUNSETS The Allyl Chloride Panel has decided to disband after ten years of activity. The Panel undertook toxicological research projects to evaluate toxicity potential and submitted research reports to government agencies. Specifically, the Panel conducted subchronic, pharmacokinetic, and teratogenicity testing. The Panel consisted of representatives from BF Goodrich Company, Shell Oil Company, Ethyl Corporation, and Dow Chemical Company. Dr. James Quast of Dow served as chairman. Our congratulations to the Chairman and the Panel members for a job well done. H. C. Shah IS YOUR CHEMICAL USED IN PESTICIDES? The EPA Office of Pesticide Programs is reviewing all inert ingredients in pesticide formu lations. Recent concern over the potential hazards of the 1200-2000 inerts has prompted the review. Although EPA has authority to regulate "inerts," it has not yet done so. The Agency will begin to review a list of chemicals that are of the most concern toxicologically. This list of 53, which was published in June 1985, includes some chemicals of inter est to Special Programs -- ben zene, chlorobenzene, ethylene dichloride, ethoxyethanol, ethoxy- ethanol acetate, methoxy ethanol, di-2-ethylhexyl phthalate^, and isophorone. EPA is requesting use information on the 53 sub stances. For chemicals currently in use, the Agency may request addi tional toxicity data, or many ban or restrict use in pesticides. EPA is considering using Section 4 of TSCA to require any testing that may be necessary. After review of this first list is complete, the Agency will issue additional lists until the review of all inerts is finished. E, J. Moran NEWS BRIEFS FLUOROCARBON PANEL APPROVES BUDGET (Ogunquit, Maine, June 20) At the Management Briefing of the Fluoro carbon Panel, the supporting com panies approved a $1,815 million budget for calendar year 1986. FLUOROCARBON PANEL COMMENTS ON EPA DOCUMENTS (Washington, August 22) The Fluorocarbon Panel submitted com ments to EPA on four draft docu ments prepared as part of an En vironmental Impact Statement on the effect of control measures for the protection of the ozone layer. EPA and the Department of State are conducting the EIS as background to the U.S. position on' activities under the UNEP Convention for the Protection of the Ozone Layer. In addition, a UNEP resolution, calling for further study to address both short and long-term strategies, is being implemented. A UNEP Steer ing Committee meeting is planned for September 17-18, 1985, in London to organize workshops, to be held within the next year. OLI 3597 4. I 6 # CMA-EPA-NRDC DISCUSSIONS ON TESTING NEAR FRUITION (Washington, August 23) EPA is expected to issue a proposed procedural rule that will describe new procedures and new time tables for the determination of testing requirements under Sec tion 4 of TSCA. A draft rule agreed to by CMA, NRDC and EPA was developed through a series of discussions between representatives of the three organizations held over the past five months. CMA was represen ted by James Mieure of the Phthalate Esters Panel; Carl Umland, Mark Christman and Paul Wright of the Health and Safety Committee; Langley Spurlock, Sanford Gaines and Garrity Baker of the staff, and outside counsel Robert Sussman. Central to the draft rule is a procedural alternative to the test rule -- direct negotiation between industry and EPA of a consent order -- as a means to satisfy EPA's Section 4 requirements. The consent order procedure would be used in some instances where there are no substantial differences between EPA and the industry on needs for testing. A revised timetable for the progress of chemicals from Interagency Testing Committee referral, through EPA decisionmaking, to the start of testing, for both consent order and test rule, forms a crucial part of the pro posal. The ITC has indicated a willing ness to revise its timing for referrals, when EPA adopts the new procedural rule. EPA plans to issue the rule as an interim final rule to allow its immediate use. EPA will, however, solicit comments on the proposed rule, due 60 days after its formal issuance. Details of the final procedural rule will be featured in the next issue of the Newsletter. CMA ALLIANCE CONFRONTS WATER QUALITY GUIDELINES (Washington, July 10) Representa tives of the Phthalate Esters Panel met with members of the Water Quality Standards Task Group of the Environmental Management Committee and the Hazard Assess ment Task Group of the Health and Safety Committee to discuss a new regulatory issue. EPA's Office of Toxic Substances has recently decided to incorporate the testing required to set a water quality standard into some TSCA Section 4 test rules. Priority pollutants that are recommended to EPA by the ITC will be subject to this new require ment. Chemicals that are not priority pollutants may also be required to undergo this battery of tests. The testing involved is extensive -- eight salt water and eight fresh water acute studies, several chronic studies and biocon centration studies. The cost of this testing could range from $250,000 to $500,000 per chemical. A proposed Test Rule on one of the phthalate esters is due to be pub lished in October 1985 and will require water quality testing. Many scientists feel that this amount of testing is excessive, and that water quality standards could be based upon a more streamlined battery of tests. The joint CMA group will meet with EPA scientists of EPA's Water Office to explore ways to develop a more reasonable and scientifically sound battery. DOW SPONSORS DIOXIN SEMINAR (Midland, Michigan, June 25) The Dow Chemical Company hosted an educational seminar for the Dibenzofurans/Dibenzodioxins Panel and Task Group members. Dr. Kenneth Burgess, Panel Chairman, and various represen tatives from Dow and the Mon santo Company presented the latest information on health and environmental effects, and the fate and environmental sources of dibenzodioxins and dibenzofurans. Tours of Dow's Analytical and Toxicology laboratories were also arranged for the attendees. According to the Program Manager, Robert Fensterheim, the Seminar was "extremely success ful," and provided the Panel with a, " . . . technical base from which to develop its comments on various EPA proceedings." KETONES PANEL PERSUADES EPA (Washington, August 16) The EPA Test Rules Development Branch has concluded that neither methyl ethyl ketone nor methyl isobutyl ketone are mutagenic and therefore no further testing is recommended. This decision coincides with the scientific position supported by the Ketones Panel. The Panel had met with EPA scientists on June 19 to discuss the interpretation of mutagenicity studies on these ketones. The Panel Chairman, Dr. Richard Phillips of Exxon Corporation, opened the meeting by commenting on the Agency's evaluation cri teria Dr. Ron Slesinski of Union Carbide Corporation then dis cussed interpretation criteria for unscheduled DNA synthesis assays. Dr. Rick McKee, Exxon Corporation, covered criteria for transformation assays, and Panel consultant Dr. Steve Haworth reviewed the mouse lymphoma assay. Given EPA's ultimate decision, the meeting must be viewed as highly successful. CHAP RELEASES DRAFT DOCUMENT (Washington, July 15) The Con sumer Product Safety Commission's Chronic Hazard Advisory Panel has been reviewing research data on di-2-ethylhexyl phthalate in chil dren's products to provide guidance to the Agency on a need for regu lation. The draft report of the CHAP has been released for peer review. The report concludes that exposure of children to DEHP in products such as pacifiers and teething rings results in a very small risk. Al though DEHP is a rodent liver carcinogen, the CHAP evaluated data on the mechanism of action and concluded that a plausible mechan ism is by induction of liver peroxi somes, which may lead to oxidative liver damage and, in turn, to carcinogenesis. If this mechanism is correct, there would be a thres hold below which no damage occurs and therefore no tumors would result. The Phthalate Esters Panel has filed extensive comments on the report. The comments suggest that the CHAP review the metabolic and species differences data. The Panel believes that humans are much less sensitive to DEHP effects, and that certain key metabolic differences between rodents and humans should be highlighted. The CHAP final report is due to be released by the end of September. OLI 3599 EHA PANEL COMMENTS ON PROPOSED RULE (Washington, July 17) The Ethylhexanoic Acid Panel submit ted comments on the proposed test rule on ethylhexanoic acid. The rule proposed subchronic, developmental and pharmaco kinetics testing based upon concern that dermal exposure might occur during processing. The Panel commented that expo sure to EHA is so limited that there is no likelihood that EHA could pose a significant risk to workers, regardless of the out come of the proposed testing. EHA is used solely as an interme diate in the synthesis of other chemicals and is manufactured and consumed entirely in closed systems. To obtain additional information on potential exposure, the Panel is sponsoring a survey of users. The Panel also commented on the rationale for requiring testing, stating that the subchronic and developmental testing is unjus tified and that pharmacokinetics testing is needed only if effects are found in other tests. Final ly, the Panel recommended streamlining the proposed pharma cokinetics testing to provide data in a more timely and cost efficient fashion. RESEARCH NEWS GLYCOL ETHERS CANDIDATE FOR NTP TESTING Three glycol ethers -- 2-methoxy- ethanol, 2-ethoxyethanol, 2-butoxyethanol and their respec tive acetates -- are candidate chemicals nominated for testing in - the National Toxicology Program. The chemical most advanced in the selection process is 2-butoxy ethanol (EGBE). NTP's Chemical Evaluation Committee supported nomination of EGBE for genotox- icity, teratology, chemical dispo sition, subchronic (including immuno- toxicity), and carcinogenicity studies. The Glycol Ethers Panel responded to a Federal Register notice which solicited comments on the testing recommendations. The NTP Executive Committee recently approved entry of 2-butoxyethanol into the testing program. The remaining five glycol ethers are in an earlier stage of the selection process. Following the preparation of Executive Summaries on each of the compounds, the CEC met in July and recommended: 1) inhala tion comparative chemical disposition studies on all five; and, 2) toxicity (hematotoxicity, immunotoxicity, neurological effects) and carcino genicity studies via inhalation on 2-methoxymethanol and 2-ethoxy- ethanol. The toxicity and carcino genicity studies were given high priority. Public comment on the testing recommendations will be solicited in about a month. The NTP selection process for these five glycol ethers is expected to be completed in February 1986, The Panel is maintaining a close liaison with the NTP and hopes to establish a Panel/NTP Work Group. NAPHTHENATES PANEL REACHES TESTING MILESTONE The Naphthenates Panel completed the first phase of its dermai ab sorption study on lead and cobalt naphthenates. The results have been submitted to EPA under a 1984 agreement with the Agency. The Panel and EPA will discuss the need for additional testing in the near future. OLI 3600 9 TITANIUM DIOXIDE PANEL COOPERATES WITH NCI The National Cancer Institute has begun a feasibility epidemiology study of titanium dioxide work ers. The Panel is fully cooperat ing in this study to provide NCI with necessary information to make a decision on whether to undertake a full epidemiology study. NCI's decision is expec ted in March 1986. GOOD NEWS FOR THE ZDDP PANEL The ITC has decided to defer indefinitely recommendations for health and environmental effects testing on zinc dialkyl dithiophosphates. Proactive research by the Panel and communication of the findings to the ITC and EPA were largely responsible for the ITC decisions. Congratulations to all Panel and TRTG members for a job well done! PEOPLE EOIC ENVIRONMENTAL TASK GROUP LEADERSHIP CHANGES Michael E. Nevile of Dow Chemical USA was elected to serve as chairman of the Ethylene Oxide Industry Council Environmental Task Group. He replaces Dr. Vincent Marchesani of ICI Ameri cas, who resigned to accept an appointment as a member of CMA's Environmental Management Com mittee. We congratulate Vince Marchesani for his fine contributions to the work of the Task Group and anticipate further success under the new direction of Mike Nevile. METAL CATALYSTS PANEL HOLDS ELECTIONS Dr. Keith Farmery of Katalco Corporation was re-elected Chairman and Dr. Marvin Friedman of American Cyauamid Company was elected Vice-Chairman at a recent Metal Catalysts Producers Panel meeting. We offer congratulations to both, and look forward to con tinued Panel progress under their leadership. VINYL CHLORIDE PANEL CHANGES LEADERSHIP Dr. William Gaffey of Monsanto Company will serve as the new Vinyl Chloride Panel Chairman. He replaces Dr. Maurice Johnson of BF Goodrich Company, who retired in June. Congratulations to Bill Gaffey and best wishes for an active retirement to Maurice Johnson. STACK PROMOTED Special Programs congratulates Dr. Carol Stack of the Division staff on her recent promotion to Associate Director for Health and Safety Programs. As Associate Director, she will be the principal coordinator for health and safety issues in the Special Programs Division, and will act as Division liaison with task groups of the CMA Health and Safety Committee. In addition to her new responsibilities, she will remain the manager of the programs on glycol ethers, benzene, chloro benzenes, cumene, ketones, and zinc dialkyl dithiophosphates. RECENT RELEASES FEDERAL REGISTER NOTICES EPA AIR POLLUTION CONTROL; DECISION NOT TO REGULATE VINYLIDENE CHLORIDE AND SOLI CITATION OF INFORMATION. (50 FR 32632-32634 August 13, 1985) 4,4-METHYLENEDIANILINE; DECI SION TO REPORT TO THE OCCU PATIONAL SAFETY AND HEALTH OLI 3601 10 ADMINISTRATION. (50 27674-27681 July 5, 1985) FR POLYCHLORINATED BIPHENYLS IN ELECTRICAL TRANSFORMERS. (50 FR 32176 August 9, 1985) DHHS-FDA; "CHLOROFLUORO CARBON PROPELLANTS IN SELF- PRESSURIZED CONTAINERS; PROPOSED ESSENTIAL USES." (50 FR 30210 July 24, 1985) DHHS-EPA; "ASSESSMENT OF CARBON TETRACHLORIDE AS POTENTIALLY TOXIC AIR POL LUTANT." (50 FR 32621 Au gust 13, 1985) SPECIAL PROGRAMS COMMENTS Comments to the EPA on four draft documents in support of the ENVIRONMENTAL IMPACT STATEMENT ON CONTROL MEA SURES FOR THE PROTECTION OF THE OZONE LAYER. (Filed by the Fluorocarbon Panel, Au gust 21, 1985) Comments to the CONSUMER PRODUCTS SAFETY COMMISSION on the CHRONIC HAZARD ADVI SORY PANEL REPORT on Di (2-ethylhexyl) Phthalate. (Filed by the Phthalate Esters Panel, August 14, 1985) Comments to the EPA HEALTH AND ENVIRONMENTAL REVIEW DIVISION on MUTAGENICITY TEST DATA. (Filed by the Ketones Panel, July 12, 1985) Comments to EPA on the TEST RULE PROPOSAL FOR EHA. (Filed by the Ethylhexanoic Acid Panel, July 15, 1985) Additional Comments to EPA on the ADVANCE NOTICE OF PRO POSED RULEMAKING ON 2-(2- Butoxyethoxy) Ethyl Acetate. (Filed by the Glycol Ethers Panel, February 19, 1985) RESEARCH REPORTS 1. Evaluation of Tris (2-ethylhexyl) Trimellitate in the Rat Primary Hepatocyte Unscheduled DNA Syn thesis Assay. (Trimellitate Esters Panel) 2. A 21-Day Dose-relationship Study of Di (2-ethylhexyl) Phthalate in Rats. (Phthalate Esters Panel) 3. Evaluation of Tris (2-ethylhexyl) Trimellitate (TOTM) in the CHO/HGPRT Forward Mutation Assay. (Trimellitate Esters Panel) 4. Evaluation of dimethyl phthalate in the in vitro Transformation of BALB7-3T3 Cells Assays. (Phthalate Esters Panel) 5. Evaluation of butyl benzyl phthalate in the in vitro Transformation of BALB/C-S'TS Cells Assays. (Phthalate Esters Panel) 6. Evaluation of di-(hexyl, octyl, decyl) phthalate in the in vitro Transformation of BALB/C-3T3 Cells Assays. (Phthalate Esters Panel) 7. Evaluation of di-(heptyl, nonyl, undecyl) phthalate in the in vitro Transformation of BALB/C-3T3 Cells Assays. (Phthalate Esters Panel) 8. Evaluation of diisodecyl phthalate in the in vitro Transformation of BALB7G-3T3 Cells Assays. (Phthalate Esters Panel) 9. Evaluation of diundecyl phthalate in the in vitro Transformation of BALB7b-3T3 Cells Assays. (Phthalate Esters Panel) OLI 3602 10. "SUMMARY: Research Program on Effect of Chlorofluorocarbons on the Atmosphere, Revision 21," Available June 1985. (Fluoro carbon Panel) 11. CHO/HGPRT Mutation Assay on Oleylamine in the Presence and Absence of Exogenous Metabolic Activation. (Oleylamine Panel) 12. Absorption Studies on Cobalt and bead Naphthenates in Commercial Products. (Naphthenates Panel) UPCOMING EVENTS PROCESS SAFETY MANAGEMENT SYMPOSIUM CMA will present a two-day symposium and workshop series on process safety management, November 5-6, 1985, at the Sheraton New Orleans, New Orleans, Louisiana. The seminar will provide an overview of the process safety field. The work shops will focus on Failure Mode and Effect Analysis, HAZOP, and "What if...." For further infor mation contact Cindy Drucker at CMA. RISK ANALYSIS SYMPOSIUM CMA will present a two-day symposium and series of work shops on "Risk Analysis in the Chemical Industry" on September 23-24, 1985, at the Hyatt Regency Hotel in Washington, D.C. For more information, contact Joanne Padron, at 202/887-1277. PCB BRIEFING AND WORKSHOP McGraw-Hill's Electric Utility Week in association with Executive Enterprises, Inc. will present the Fourth Annual PCB Regulatory Briefing and Second Annual PCB Disposal and Spill Clean-Up Workshop on November 6-7, 1985, at the Marriott Crystal Gateway in Arlington, Va. For more informa tion call 212/489-2680.