Document ZJNKXnx9291jG10De2BaDLyOO

A __________L_.. ^1:___________ __ . G<JNFl DEMTiAU ! ATTENDEES JANUARY 17, 1973 MANUFACTURING CHEMISTS ASSOCIATION DR. MAC ROY CASQUE, MEDICAL DIRECTOR OLIN CORPORATION DR. RICHARD KOCIBA, PATHOLOGIST THE DOW CHEMICAL COMPANY DR. THEODORE TORKELSON, TOXICOLOGIST THE DOW CHEMICAL COMPANY ICI, ENGLAND MR. DON ELLIOTT, GENERAL MANAGER - PRODUCTION SOLVENTS AND MONOMERS GROUP DR. DAVID DUFFIELD, MEDICAL DEPARTMENT MONTEDISON, ITALY DR. TIZIANO GARLANDA. PROTEZIONE AMBIENTALE E SICUREZZA MILANO PROF. DOTX EMILIO BARTALINI, HEAD OF MEDICAL SECTION MILANO SOLVAY et Cie DR. MARCEL-JEAN LEFEVRE, TOXICOLOGICAL OFFICER BRUSSELS MR. AUGUSTE GOSSELIN, INGENIEUR E.E.G. ` BRUSSELS RHONE-PROGIL DR. JEAN BERROD, MEDICAL CHIEF / PARIS _/ UNIVERSITY OF BOLOGNA PROF. CESARE MALTONI, INSTITUTO Di ANCOLOGIA URL 18288 r V FUTURE EUROPEAN WORK 1. WILL KEEP SURVIVING ANIMALS FOR THEIR LIFETIME - OVER 30 WEEKS 2. HAVE STARTED MORE RAT EXPOSURES 250 PPM <100-125 PPM MAY BE ADDED) 50 PPM 25 PPM 3. EPIDEMIOLOGY BY EACH COMPANY USING A STANDARDIZED FORM DEVELOPED BY ICI 4. CONSIDERING a) 2 EXPOSURES PER WEEK 1000 PPM OR LESS FOR ONE YEAR AND HOLD FOR LIFETIME b) 2-3 MONTHS OF 4-HOUR EXPOSURES 5. CONSIDERING SIMULATING WORKERS1 EXPOSURES fDURATION, FREQUENCY, CONCENTRATION) BY SCALING DOWN TO RATS 6. PROBABLE COLLECT SPUTUM SAMPLES FOR EVALUATION URL 18290 `V "V V \ CONCLUSIONS FROM EUROPEAN INFORMATION ANIMAL STUDIES - WELL DONE; LITTLE REASON TO DOUBT r POSITIVE AT 250 PPM AFTER 82 WEEKS - NEGATIVE AT 50 PPM AFTER 82 WEEKS - HAVE ADDED MORE ANIMALS PRELIMINARY HUMAN - QUESTIONABLE SPUTUM - QUESTIONABLE EAR (SKIN) - WILL DO EPIDEMIOLOGY BY COMPANY USING A COMMON QUESTIONAIRE RELATIONS TO U. S. & MCA - EXCELLENT; CONTACTS ESTABLISHED - WOULD LIKE TO SIT IN WITH MCA RESEARCH COORDINATORS - WISH TO MEET BEFORE OCTOBER 1974 - WOULD NOT LIKE CONVERSATIONS BETWEEN INDUSTRIAL BIO-TEST AND EUROPE OR MALTONI AND U. S. fUNLESS THEY WERE PRESENT) - WOULD LIKE TO HAVE U.S. CO-SPONSOR ITALIAN WORK / 81 WEEK SUMMARY 4 HOURS PER DAY; 5 DAYS PER WEEK FOR 52 WEEKS EXPOSURE CONCENTRATIONS \ 10000 6000 2500 500 250 ALIVE/STARTED 4/60 14/60 30/60 31/60 27/60 CARCINOMA OF CERUMINAL*" rZYMBAL) GLANDS . ^TUMORS* ENDOTHELIAL* ^ ANGIOSARCOMA NEPHROBLASTOMA** OF LIVER OF KIDNEY 13 3 2 (26 WEEKS) 1 0 4 6 <50 WEEKS) 1 11 3 1 4 0 2 50 0 VA 2500 40/60 42/60 24/96 o 0 _0 19 0 0 J) 13 0 0 _0 10 ( ) WEEK WHEN FIRST OBSERVED * METASTISIS TO LUNG ** METASTISIS TO LIVER AND SPLEEN NO OBSERVED SEX DIFFERENCE IN INCIDENCE 3 OTHER TUMORS OBSERVED BUT NOT CONSIDERED RELATED TO EXPOSURE AT THIS TIME 628 J fttf)