Document Yrpw5aXeZ18OvxDjbBnavrm6O

H-24516: Subchromc I'oxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations AR226-3201 DuPont-5368 TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 o f 5 Laboratory Project ID: DuPont-5386 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) Author: Gregory S. Ladies, Ph.D., D.A.B.T. Study Completed on: December 3,2001 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number Service Code Number: Sponsor Study Numbi Page 1281 o f 1500 Company Sanitized. Does not contain TSC CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS P! ADULTS AND F, ADULTS 1282 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS P: 1-0 0 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643148 643229 643218 643207 643280 643211 643197 643242 643251 643147 643276 643254 571.6 518.8 632.6 544.9 627.7 591.0 622.8 645.3 582.2 613.3 759.3 546.8 0.019 0.016 0.023 0.023 0.027 0.021 0.024 0.022 0.018 0.020 0.023 0.018 1283 Company SanH*ed. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-O 25 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643287 643188 643230 643170 643144 643277 643214 643166 643153 643177 643291 643167 643223 643233 643183 643219 643263 500.5 688.9 544.3 619.2 519.8 680.8 622.6 615.7 589.9 593.7 635.8 617.1 534.2. 529.0 628.4 645.9 539.5 0.016 0.021 0.016 0.017 0.018 0.029 0.018 0.020 0.013 0.016 0.017 0.023 0.023 0.020 0.020 0.026 0.019 1284 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-0 100 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643313 643146 643312 643199 643216 643245 643301 643200 643157 643238 643164 643154 643208 643190 549.8 624.4 554.9 564.1 555.0 501.8 604.8 616.4 603.9 535.4 639.8 460.3 425.2 564.9 0.026 0.028 0.012 0.022 0.023 0.018 0.018 0.024 0.030 0.027 0.019 0.020 0.018 0.023 1285 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: VII-0 250 mg/kg/day ANIMAL NUMBER 643289 643171 643158 643249 643161 643248 643285 643274 643192 643222 643160 643191 643302 643317 FINAL BODY 456.0 628.2 639.7 583.9 587.8 407.7 498.3 527.3 613.3 542.6 509.0 541.5 547.9. 497.4 THYROID GLAND 0.027 0.028 0.043 0.014 0.030 0.018 0.016 0.024 0.025 0.025 0.018 0.024 0.030 0.025 1286 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-0 0 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643459 643480 643363 643421 643.419 643401 643455 643378 643447 643478 643386 377.8 330.8 379.1 286.3 402.9 324.0 331.8 376.7 365.9 339.1 354.3 0.019 0.019 0.017 0.014 0.016 0.020 0.027 0.024 0.023 0.012 0.021 1287 Company Sanitized. Does no! contain TSCA C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-0 25 mg/kg/day 64339$ 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643452 643475 643372 643400 643395 643457 342.4 355.0 391.5 377.9 353.7 381.8 352.0 346.4 405.7 358.6 366.9 375.0 388.9 346.7 356.0 350.5. 371.1 0.021 0.021 0.024 0.016 0.020 0.022 0.029 0.017 0.021 0.027 0.018 0.020 0.022 0.018 0.026 0.016 0.023 1288 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-0 100 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643320 643428 643439 643353 643339 643337 643416 643427 643434 643349 643333 643460 367.8 380.6 363.0 360.9 353.0 381.7 341.5 329.2 360.8 365.2 346.8 360.0 0.019 0.018 0.024 0.021 0.016 0.017 0.024 0.016 0.026 0.018 0.025 0.019 1289 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-0 ANIMAL NUMBER 643467 643443 643417 643413 643338 643335 643468 643440 643326 643365 643328 643449 250 mg/kg/day FINAL BODY THYROID GLAND 345.4 259.3 306.4 283.6 357.6 362.4 319.3 390.6 361.5 380.5 312.4 377.1 0.025 0.013 0.013 0.028 0.026 0.018 0.027 0.024 0.025 0.024 0.019 0.019 1290 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fx ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: 1-1 - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID SEMINAL GLAND PROSTATE VESICLES TESTES 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 329.2 446.1 387.8 407.7 407.3 362.9 396.7 352.3 353.4 407.4 389.7 400.4 361.8 14.069 20.638 16.432 16.834 17.318 17.748 18.285 16.343 16.544 20.000 19.329 18.551 15.250 2.789 3.502 3.105 3.384 3.355 3.455 3.555 2.889 3.145 3.767 3.141 3.562 3.030 0.023 0.021 0.013 0.020 0.015 0.021 0.019 0.020 0.021 0.010 0.020 0.023 0.020 0.314 0.616 0.474 0.412 0.508 0.520 0.494 0.487 0.279 0.526 0.692 0.409 0.255 1.001 1.574 0.963 1.186 1.377 1.186 1.537 1.047 0.929 1.180 1.288 1.258 1.070 3.209 3.859 3.296 3.440 3.407 3.071 3.543 3.031 3.109 3.388 3.137 3.211 3 .204 EPIDIDYMIDES 0.724 0.867 0.742 0.886 0.777 0.747 0.763 0.688 0.645 0.711 0.825 0.759 0.750 DuPont-5386 BRAIN 1.820 2.045 2.028 1.979 2.036 1.974 2.190 1.863 1.966 1.992 2.060 1.944 2.051 1291 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-1 - 25 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 357.6 379.4 361.1 369.9 378.6 382.2 362.2 392.4 423.8 373.8 368.5 412.5 359.5 308.0 355.6 37.2.3 15.301 17.911 15.145 16.166 19.171 18.457 16.122 20.397 18.465 16.868 14.743 18.666 15.014 13.994 17.132 17.458 KIDNEYS 3.083 2.654 3.131 3.005 3.497 3.307 3.140 2.828 3.574 3.283 3.234 3.514 3.303 2.753 3.071 3.085 THYROID GLAND 0.019 0.018 0.018 0.013 0.016 0.015 0.018 0.017 0.017 0.027 0.018 0.011 0.015 0.014 0.018 0.015 PROSTATE 0.464 0.355 0.453 0.278 0.448 0.517 0.543 0.487 0.502 0.303 0.362 0.417 0.342 0.312 0.347 0.407 SEMINAL VESICLES 1.034 0.792 1.136 0.925 0.941 1.435 1.202 1.287 1.375 1.051 0.849 1.270 1.137 0.844 0.836 1.068 TESTES 3.022 3.220 2.977 3.061 3.045 3.052 3.150 3.297 3.442 3.142 3.309 3.386 3.117 2.731 3.233 3.283 EPIDIDYMIDES 0.753 0.688 0.809 0.623 0.687 0.842 0.724 0.815 0.839 0.824 0.789 0.776 0.759 0.545 0.579 0.762 DuPont-5386 BRAIN 2.016 1.921 1.958 1.968 1.997 1.921 1.986 1.915 2.031 2.044 1.979 1.977 1.863 1.771 1.896 1.948 1292 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: V-l - 100 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 337.6 366.8 330.2 418.8 422.4 367.0 366.3 382.6 386.4 379.5 380.4 375.6 11.604 16.720 13.625 18.190 22.330 16.428 16.743 19.704 17.954 17.448 18.392 16.066 KIDNEYS 3.114 3.256 2.826 3.674 3.652 2.918 3.479 3.053 3.115 2.912 3.415 2.976 THYROID GLAND 0.022 0.018 0.015 0.015 0.017 0.012 0.006 0.013 0.016 0.021 0.016 0.013 PROSTATE 0.298 0.448 0.248 0.325 0.365 0.308 0.341 0.349 0.389 0.309 0.531 0.509 SEMINAL VESICLES 0.911 1.150 0.734 1.342 1.518 1.027 0.931 1.013 0.822 1.060 1.537 0.978 TESTES 3.211 3.375 3.058 3.265 3.079 3.168 3.568 3.154 3.132 2.851 3.781 2.997 EPIDIDYMIDES 0.696 0.774 0.690 0.753 0.794 0.782 0.728 0.726 0.729 0.659 0.824 0.707 w DuPont-5386 BRAIN 2.138 1.987 1.839 1.938 1.935 1.931 1.832 1.935 1.868 2.074 2.153 1.961 129? Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: VII-1 - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 351.2 362.1 470.3 346.4 367.7 338.8 336.0 344.6 327.9 361.9 352.9 364.7 16.054 15.376 19.170 14.994 15.545 15.621 17.685 14.558 15.967 15.602 15.802 16.070 KIDNEYS 3.249 3.175 3.832 3.064 3.271 2.961 3.348 3.205 3.314 3.513 2.753 3.348 THYROID GLAND 0.018 0.018 0.022 0.014 0.026 0.014 0.018 0.021 0.022 0.020 0.010 0.018 PROSTATE 0.459 0.495 0.667 0.470 0.494 0.385 0.280 0.362 0.315 0.300 0.275 0.368 SEMINAL VESICLES 1.196 1.243 1.257 1.190 1.050 1.397 0.891 0.878 1.175 0.881 1.040 0.809 TESTES 2.631 3.093 4.208 2.779 2.796 2.566 3.210 3.334 2.955 2.877 2.801 3.217 EPIDIDYMIDES 0.728 0.643 0.857 0.659 0.663 0.715 0.684 0.717 0.676 0.655 0.629 0.603 DuPont-5386 BRAIN 1.999 2.024 2.030 1.994 1.933 1.897 1.852 1.929 2.084 1.990 2.078 1.922 1294 Company S a ^ e d . Does not confa'n TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL PINAL BODY AND ORGAN WEIGHTS - Pi ADULTS t FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-1 - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROI GLAND UTERUS BRAIN 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 205.8 211.3 190.2 228.3 227.6 223.5 231.4 215.5 198.6 250.7 242.5 230.8 183.4 8.850 9.353 6.655 8.919 8.715 9.397 10.733 9.492 7.356 9.956 9.866 11.434 7.093 1.717 1.697 1.878 1.882 1.947 1.926 2.094 1.921 1.647 1.902 1.851 2.216 1.838 0.014 0.017 0.016 0.021 0.020 0.015 0.014 0.017 0.017 0.017 0.014 0.015 0.009 0.356 0.380 0.465 0.643 0.470 0.389 0.463 0.354 0.418 0.329 0.539 0.371 0.406 1.756 1.883 1.948 1.817 1.811 1.795 1.923 1.848 1.772 1.836 1.853 1.764 1.769 DuPont-5386 1295 Company Sanitized. Does notcontain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-1 - 25 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 209.6 234.8 217.0 239.8 230.5 286.7 261.3 208.0 278.6 203.7 171.9 238.3 215.0 201.8 201.1 212.4 232.7 9.907 9.838 9.399 9.492 10.921 12.292 10.396 7.671 12.246 7.800 6.831 12.077 8.056 8.438 7.467 9.262 10.916 1.905 2.037 2.149 2.030 2.146 2.596 2.179 1.943 2.421 1.945 1.695 2.125 1.856 1.756 1.697 1.858 2.303 0.015 0.012 0.011 0.016 0.017 0.011 0.016 0.020 0.013 0.013 0.020 0.013 0.018 0.019 0.008 0.013 0.018 ' 0.428 0.421 0.263 0.854 0.631 0.410 0.510 0.545 0.570 0.488 0.580 0.357 0.401 0.324 0.341 0.398 0.477 1.905 1.822 1.825 1.829 1.867 1.920 1.935 1.962 1.889 1.859 1.794 1.890 1.959 1.715 1.676 1.746 1.848 DuPont-5386 1296 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL PINAL BODY AND ORGAN WEIGHTS - Pi ADULTS PINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-1 - 100 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 224.5 229.7 215.9 193.7 250.9 249.5 219.5 235.4 228.7 187.1 212.8 237.3 8.740 8.193 8.707 8.560 12.280 11.101 10.179 10.573 10.055 7.631 9.426 9.675 2.052 2.029 1.999 2.236 2.284 2.028 2.326 1.981 2.470 1.603 1.832 1.774 0.020 0.014 0.017 0.012 0.014 0.011 0.014 0.021 0.018 0.018 0.014 0.021 0.561 0.555 0.612 0.361 0.357 0.350 0.326 0.445 0.498 0.428 0.610 0.294 1.989 1.735 1.914 1.743 1.875 1.712 1.702 1.755 1.780 1.784 1.869 1.730 DuPont-5386 1297 Company S a n ^ a d . n*oa no! confab TSCA CW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-1 - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 237.0 203.8 249.1 204.8 234.5 226.8 201.9 219.0 216.4 230.5 213.0 232.9 10.811 7.861 9.966 10.391 11.348 9.620 8.987 10.929 9.820 10.745 9.512 9.845 2.189 1.892 2.169 2.043 2.043 1.880 1.794 2.199 2.062 2.407 1.628 2.157 0.013 0.012 0.013 0.009 0.012 0.016 0.012 0.018 0.014 0.011 0.012 0.014 2.487 0.472 0.496 0.348 0.351 0.329 0.471 0.392 0.367 0.348 0.395 0.535 1.819 1.920 1.746 1.765 1.882 1.874 1.742 1.800 1.823 1.816 1.768 1.769 DuPont-5386 1298 eaipassf Sanitized. Does not contain TSCA CB) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX NN INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS 1299 Company SanWzed. Does no* contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pi ADULTS EXPLANATORY NOTES Abbreviations AK = FD = SD = Accidentally killed Found dead Sacrificed by design 1300 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643147 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1301 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pa ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643148 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: NONE3 MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE a No gross observations were entered into the database at the time of necropsy. However, protocol tissues were saved and no abnormalities were detected when these tissues were re-examined. 1302 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643155 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE )) 1303 Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643163 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE * 1304 Company Sanitized. Does not contain TSCA CIBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643176 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ' 1305 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643196 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1306 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643197 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1307 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643207 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1308 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643211 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1309 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643218 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1310 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643229 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1311 Company Sanitized. Does not contain TSC CBI H-24516: Subchronic Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643239 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1312 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643242 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1313 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE : 0 mg/kg/day ANIMAL #: 643251 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE D 1314 Company lini cnnfin CIS! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643254 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1315 Company Sanitized. Does not contain TSCACBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643270 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1316 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643271 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1317 Company SanWzed. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643276 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1318 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643280 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE ' THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1319 fiompany Sanitized. Does not contain TSCA OBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643284 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE ATOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE '` 1320 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643144 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1321 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity jO^Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643153 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION- NONE ' SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1322 ^ mPany Sanitized Does not contain Tsc a CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643166 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED? DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1323 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643167 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION? ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1324 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643170 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1325 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643177 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1326 Company Sanitized. Does not contain TSCA CBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643183 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1327 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643184 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1328 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643188 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1329 Company SanHitiizreedd. DDooes not contain tSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL # : 643198 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: ) 'NONE 1330 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643214 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED * MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE . THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1331 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643219 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1332 Company Sanitized. Does not contain TSCA CBI H-24516: Subebronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643223 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1333 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643230 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1334 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643233 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1335 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643261 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: . MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1336 Company San;t!zed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643263 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1337 Company S a n d e d . Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643277 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . 1338 Company SanRbed. D oes no! contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643287 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1339 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643291 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1340 Company Sa"***?*. Does nof contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643146 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1341 limnpm y S a ^ e d . Does not contain TSCA CBI 2. ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643154 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1342 Company S a n d ed . Ooes no! contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643156 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1343 omnnrw s***--* rtnannf ennf*!n TSCA GB! Company S an d ed . Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643157 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ,, 1344 Comoany Ssn'*s*ed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643164 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1345 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643182 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1346 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643190 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1347 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643199 DAYS ON TEST: 107 MODE OP DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1348 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: S43200 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1349 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643208 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1350 Company SanWzed. Does not contain TSCA CBI H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643216 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1351 Comoany SanWzed. Does no! contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Flats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643227 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1352 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643238 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1353 B** ^ TSCfl cb( H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643244 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1354 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi. ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643245 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1355 Company Sani!feed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643255 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1356 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643267 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ` 1357 Company S a in ted . Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643301 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1358 Company Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643312 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1359 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643313 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1360 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643158 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1361 Company Sanitized. Does not contain TSCACBr H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643160 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1362 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643161 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1363 Company SanWzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643171 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1364 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643191 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS : - MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643192 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1366 Company Sanitized. Does not contain TSCA CBI Jl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643203 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1367 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643222 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1368 Company Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643248 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1369 Company anltized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643249 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: . NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1370 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643274 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1371 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643278 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1372 C mpany Sanltf2ed- Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643281 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ' SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1373 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643282 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1374 Company Sanitized. Does not contain TSC CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643285 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: ' MICROSCOPIC CORRELATE (selected lesions): EPIDIDYMIDES - LARGE, RIGHT; HEAD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1375 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643289 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1376 C om paq Sa^t'zed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643299 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS . THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1377 Company Sanitized. Does notcontain TSCA CHI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643302 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1378 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643317 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1379 Com Pahy Sanitized. Does no! contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643319 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS : . MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1380 C offlnanv S^nW raif. lin e* nnf contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643343 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1381 Company Sanitized Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-0 DOSE : 0 rag/kg/day ANIMAL #: 643350 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Does not contain TSCA CBI tM n 2 .) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE : 0 mg/kg/day ANIMAL #: 643352 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1383 Company Sanitized. Does not contain TSCA CBI H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643363 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1384 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643378 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1385Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643386 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643393 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1387 Company Sanitized. Does not contain TSCA C B I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pa ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643394 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1388 e '^ Doe. , contah r e e , CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643397 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): LIVER - DISCOLORATION, TAN, MOTTLED, LEFT MICROSCOPIC OBSERVATIONS: OTHER - LIVER: NECROSIS, FOCAL, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1389 Company SanVzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS * FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643401 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS : , MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1390 Comn*.nv ft* iimcut noe* not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643414 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1391 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643419 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1392 Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicily 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643420 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, PERINEUM; RIGHT FRONT LIMB MICROSCOPIC OBSERVATIONS: OTHER SKIN: NO ABNORMALITIES DETECTED THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY- OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE ORGAN NOT COUNTED IN INCIDENCE TABLES: ' NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION- NONE ` SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES- "NONE - 1393 Company Sanitized. Does not contain TSCA CUI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE : 0 mg/kg/day ANIMAL #: 643421 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1394 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643447 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: , MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1395 Cwpassy Sanfffzed. B@srse@mWmTSC CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643455 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1396 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643459 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1397 6ompany Sanitized. 0@@s sso eenaln TSC C ll H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643478 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1398 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE : 0 mg/kg/day ANIMAL #: 643480 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1399 Sanitized. Bees not contain TSC CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643325 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1400 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643334 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1401 Comnamr Sanitized. Does not contain TSC GW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643342 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1402 Company Sanitized. Does not contain TSC CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643369 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1403 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643372 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1404 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643376 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1405 Company Sanitized. Ooes not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 rag/kg/day ANIMAL #: 643395 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1406 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643399 DAYS ON TEST: 132 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1407 Company Sanitized. Does notcontain TSCA CBI H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643400 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643403 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1409 Company Sanitized. Does notcontain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643418 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING T I S S U E W E R E AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1410 ComPa,ly SanFtfced Does notcontain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643422 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1411 Company Sanitised. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643438 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1412 Company Sanitized. Does notcontain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS . GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643445 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1413 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643452 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643457 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1415 empany Sanitized, Does no!contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643464 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1416 Company Sanitized. Does no!contain T8CA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: IV-0 DOSE: .25 mg/kg/day ANIMAL #: 643475 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC'DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1417 Company * " * * * & Does no contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643479 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1418 Company Saniti*. Does not contain TSCA CBt H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643490 DAYS ON TEST: 119 MODE OP DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1419 notcontain TSCA CBi Company Sanitised* Do H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643320 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1420 Company Sanitized. Does noteontaln TSCA CBT H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643331 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1421 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643333 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED? MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1422 Con,PanF Sanitized. Does nt contain TSCA C B I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643337 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1423 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643339 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1424 Company sanff&e<f. Does notcontain t s c a c b i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643349 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1425 Sanili* t o o not contain tscacbi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643353 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1426 ^"Pany Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643357 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . 1427 ComPany Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643385 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1428 Company Sanitized. Does notcontain TSCACBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643407 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ' 1429 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643416 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1430 Company Sanitized. Does not contain TSCACBI H-24516: Subcbromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643427 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 3 1431 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643428 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1432 Company Sanitized. D oes notcontain TSCA CBI H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643434 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1433 Company SanBfeed. Does no!contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643439 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE . 1434 Company Sanitized. Does notcontain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643454 DAYS ON TEST: 99 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - STAIN, RED, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1435 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643460 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1436 J> H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643470 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1437 Company SsnRfeed. Does n!enf*f,, tC H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643473 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS : UTERUS - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1438 S a n d ed . Doss not TSCJ r a | H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643488 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS : UTERUS DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN .NOT COUNTED IN INCIDENCE TABLES: NONE 1439 CorapWF SanFffzed. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643326 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1440 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643328 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1441 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643335 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1442 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643338 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1443 Conrnany SanWzed. Doe* notcontain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643346 DAYS ON TEST: 91 MODE OF DEATH: AK GROSS OBSERVATIONS: MICROSCOPIC CORRELATE STOMACH SMALL INTESTINE SKIN (selected lesions): DISTENDED WITH GAS, DISTENDED WITH GAS, STAIN, RED, FACE SEVERE SEVERE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS . GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643348 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1445 Oo'iipdny anllked, Does no, contain TSCAcbi H-24516: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643365 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS : ' MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1446 Company SanRfced. Does noiconfarn TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643375 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1447 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643413 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1448 'flinmnMPtw Nflaew fafn T W (WSf H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643417 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE w 1449 Sanitized. Does not contain TSCA GBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643424 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1450 Company Sanitized. Doesnotcontain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 rag/kg/day ANIMAL #: 643429 DAYS ON TEST: 106 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE KIDNEYS UTERUS SKIN (selected lesions): - DILATATION, BILATERAL, PELVIS - HEMORRHAGE - OBSTRUCTION, BODY; PLACENTA - STAIN, RED, VENTRAL BODY, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1451 O fflpaiqf Sanitized. Does notcontain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643430 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1452 Contypang Sanitized. Does not eonlaln TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 rag/kg/day ANIMAL #: 643431 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE - 1453 sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643440 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE l451company Sanitized. Does notcontain TSCA CBI H-24516: Subchronie Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643443 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED? DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE ' THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1455 Company Sanitized. Doesnotcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643449 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: , MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1456 Company Sanitized. Does not contain TSCA CBI H-24516: Subchrome Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643467 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE , 1457 Company Sanitized. Does notcontain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643468 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1458 Company S anitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX OO INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS 1459 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi PUPS EXPLANATORY NOTES Abbreviations FD = Found dead 1460 Company Sanitized. Coes not contain TSG CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx PUPS DAM GROUP: II-0 DOSE: 0 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 643455 M 647028 -21 FD NO ABNORMALITIES DETECTED DuPont-5386 1461 CompanySanitised. Does notcontain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 PUPS DAM GROUP: IV-0 DOSE: 25 MG/KG/DAY DAM ANIMAL NUMBER ======= PUP PUP ANIMAL SEX NUMBER =a:SSsssssss s ss ss ss li li li li II il II II DAYS ON TEST FATE OBSERVATIONS , ======= ========== = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = 643376 M 647033 "-21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643400 M 647034 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 1462 Company Sanitized. Does not contain ts c a c b i II 11)! II 11 II II II II II II II II II II II II II II II II II II (1 II II II II II II II II II it II II If II II II II 11 II II II 11 II II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx PUPS DAM GROUP: VI-0 DOSE: 100 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE ======= srssassessss========= --====--~ OBSERVATIONS . 643320 M 647042 -21 FD F 647052 -21 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 643439 M 647036 -21 FD 647037 -21 FD F 647056 -21 FD 647057 -21 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 643331 M 647038 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647039 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647040 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647041 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED F 647058 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647059 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647060 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647061 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 647062 -21 FD ' STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED DuPont-5386 1463 Company Sanitized. Does not contain TSCA CBI li1 II i! li 11 1 to H i! ii II li li li II II II II li II II 11 II II II II II II li II II II II II li II 11 II II II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj PUPS DAM GROUP: VIII-0 DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE ====== ========= ========= ======= DOSE: 250 MG/KG/DAY OBSERVATIONS 643326 M 647046 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643365 M 647047 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643375 M 647043 -21 FD 647044 -21 FD 647045 -21 FD F 647063 -21 FD NO ABNORMALITIES DETECTED PERITONEAL CAVITY - CANNIBALIZED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED 643429 F 647065 -21 FD NO ABNORMALITIES DETECTED 647066 -21 FD NO ABNORMALITIES DETECTED 647067 -21 FD NO ABNORMALITIES DETECTED U 647029 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647030 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647031 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647032 -21 FD - WHOLE BODY - AUTOLYSIS, SEVERE 647048 -21 FD WHOLE BODY - AUTOLYSIS, SEVERE 647049 -21 FD NO ABNORMALITIES DETECTED 647050 -21 FD NO ABNORMALITIES DETECTED 647051 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647035 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647053 -21 FD WHOLE BODY - AUTOLYSIS, SEVERE 647054 -21 FD NO ABNORMALITIES DETECTED 647055 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 647064 -21 FD PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE 1464 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) DuPont-5386 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS 1465 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sacrificed by design; necropsy performed 1466 Company Sanitized. Does notcontain TSCACBI H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: I-I DOSE: 0 MG/KG/DAY . OBSERVATIONS 647081 647082 647083 647084 647085 647086 647087 647088 647089 647090 647091 647092 647093 647094 647095 .1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1467 Company SanfflzeA Doe* no* eonSaln TSCA GW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS Fx WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: 1-1 DOSE 0 MG/KG/DAY OBSERVATIONS 647096 647097 647098 647099 647100 647101 647102 647103 647104 647105 647106 647107 647108 647109 647110 -1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1468 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER MALE RATS DAYS ON TEST FATE ===== GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647111 647112 647113 647114 647115 647116 647117 647118 647119 647120 647121 647122 . 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1469 SanRbad, m m not <smMr e e l Si H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 647139 647140 647141 647142 647143 647144 647145 647146 647147 647148 647149 647150 647151 647152 647153 647154 -1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1470 Does not contain is c n c m H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS . GROUP: III-l DOSE: ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS ========= ======== = = = ss=:ss =====: = = = = = = = = = = s ~ = - 25 MG/KG/DAY 647155 .1 SP NO ABNORMALITIES DETECTED 647156 1 SP NO ABNORMALITIES DETECTED 647157 1 SP NO ABNORMALITIES DETECTED 647158 1 SP NO ABNORMALITIES DETECTED 647159 1 SP KIDNEYS - LARGE, LEFT KIDNEYS - SMALL, RIGHT; SEVERE 647160 647161 647162 647163 647164 647165 647166 647167 647168 647169 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1471 M b a d . 0e@rteeiai, m H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER -- MALE RATS DAYS ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS " " '**" 11 11 II II II II II II 11 647170 - l SP NO ABNORMALITIES DETECTED 647171 l SP NO ABNORMALITIES DETECTED 647172 l SP NO ABNORMALITIES DETECTED 647173 l SP NO ABNORMALITIES DETECTED 647174 i SP NO ABNORMALITIES DETECTED 647175 l SP NO ABNORMALITIES DETECTED 647176 l SP NO ABNORMALITIES DETECTED 647177 l SP NO ABNORMALITIES DETECTED 647178 l SP NO ABNORMALITIES DETECTED 647179 l SP NO ABNORMALITIES DETECTED 647180 l SP NO ABNORMALITIES DETECTED 647181 l SP NO ABNORMALITIES DETECTED 647182 l SP NO ABNORMALITIES DETECTED 647183 i SP NO ABNORMALITIES DETECTED DuPont-5386 1472 CompanySanHzed, Does noteonfain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS ANIMAL NUMBER ssssssssss: MALE RATS DAYS ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647196 647197 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647198 647199 647200 647201 647202 647203 647204 647205 647206 647207 647208 647209 647210 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1473 CompanySanRfeed. Does noeonlaln TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Pj. WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647211 647212 647213 647214 647215 647216 647217 647218 647219 647220 647221 647222 647223 647224 647225 - 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1474 * * * * * ^ M^ ^ ca H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS s = = s = s = s s s s s s s s s sssssssss = =:s=s= = = : == sssssssss = ss= = = : == -------------- = _ = -- = ------------------------ = 647226 647227 .1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647228 1 SP NO ABNORMALITIES DETECTED 647229 1 SP NO ABNORMALITIES DETECTED H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 WEANLINGS MALE RATS . ANIMAL DAYS NUMBER ON TEST FATE s==ss==== ===_- GROUP: VII-1 DOSE: OBSERVATIONS 250 MG/KG/DAY 647242 - 1 SP NO ABNORMALITIES DETECTED 647243 1 SP NO ABNORMALITIES DETECTED 647244 1 SP NO ABNORMALITIES DETECTED 647245 647246 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647247 1 SP NO ABNORMALITIES DETECTED 647248 1 SP NO ABNORMALITIES DETECTED 647249 1 SP NO ABNORMALITIES DETECTED 647250 1 SP NO ABNORMALITIES DETECTED 647251 1 SP NO ABNORMALITIES DETECTED 647252 1 SP NO ABNORMALITIES DETECTED 647253 1 SP NO ABNORMALITIES DETECTED 647254 1 - SP NO ABNORMALITIES DETECTED 647255 1 SP NO ABNORMALITIES 'DETECTED 647256 1 SP NO ABNORMALITIES DETECTED DuPont-5386 1476 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ..... ........................ DuPont-538(5 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS MALE RATS GROUP: V I I -1 DOSE: 250 MG/KG/DAY ANIMAL DAYS NUMBER ON TEST FATE OBSERVATIONS II II II II II II II ======= ======== =====-------------------------- : 647257 647258 647259 647260 647261 647262 647263 647264 647265 647266 647267 647268 647269 647270 647271 .1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1477 Company Sanitized. Doesnotcontain TSCA CBI H-24516: Subchronic Toxicity . 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS DuPont-5386 647272 647273 647274 647275 647276 -1 1 1 1 1 SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1478 Company Sanitized. Does not contain TSCA C BI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER FEMALE RATS DAYS ON TEST FATE ===== GROUP: II-1 DOSE: 0 MG/KG/DAY OBSERVATIONS : = ssss= = = =: sss== = : 647290 647291 647292 647293 647294 647295 647296 647297 647298 647299 647300 647301 647302 647303 647304 . 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1479 CompanySanitized. Does notcontain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647305 647306 647307 647308 647309 647310 647311 647312 647313 647314 647315 647316 647317 647318 647319 1 1 1 1 1 1 1 1 1 1 1 1 1 '1 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1480 CompanySanitized. Does notcontain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER FEMALE RATS DAYS ON TEST FATE .... GROUP: II-I DOSE: 0 MG/KG/DAY . OBSERVATIONS 647320 647321 647322 647323 647324 647325 - 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1481 Company Sanitized. Does notcontain YSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER = ss= s =: FEMALE RATS DAYS TEST FATE :sss = sss GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647343 l SP NO ABNORMALITIES DETECTED 647344 l SP NO ABNORMALITIES DETECTED 647345 l SP NO ABNORMALITIES DETECTED 647346 l SP NO ABNORMALITIES DETECTED 647347 l SP NO ABNORMALITIES DETECTED 647348 l SP NO ABNORMALITIES DETECTED 647349 l SP NO ABNORMALITIES DETECTED 647350 l SP NO ABNORMALITIES DETECTED 647351 i SP NO ABNORMALITIES DETECTED 647352 l SP NO ABNORMALITIES DETECTED 647353 l SP NO ABNORMALITIES DETECTED 647354 l SP NO ABNORMALITIES DETECTED 647355 l SP NO ABNORMALITIES DETECTED 647356 i SP NO ABNORMALITIES DETECTED 647357 l SP NO ABNORMALITIES DETECTED 647358 l SP NO ABNORMALITIES DETECTED DuPont-5386 1482 CompanySanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS ANIMAL NUMBER SSSC SSSC SC 2 FEMALE RATS DAYS ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647359 - 1 647360 1 647361 1 647362 1 647363 1 647364 1 647365 1 647366 1 647367 1 647368 1 647369 1 647370 1 647371 1 647372 1 647373 ' 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1483 CompanySanitized. Does notcontain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE ;ss=:sss:ss=:=== GROUP: IV-1 DOSE 25 MG/KG/DAY OBSERVATIONS 647374 647375 .l SP l SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647376 647377 647378 647379 647380 647381 647382 647383 647384 647385 647386 647387 647388 l SP l SP l SP l SP l SP i SP l SP l SP i SP l SP l SP l SP l SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1484 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS ANIMAL NUMBER FEMALE RATS . DAYS ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS DuPont-5386 647389 647390 647391 647392 647393 -1 1 1 1 1 SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1485 Oompany Sanitized. Does not contain TSCACB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. WEANLINGS ANIMAL NUMBER sssssss FEMALE RATS DAYS ON TEST FATE ss=ss ssssss: GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS 11 11 Il H II II II II li 647406 647407 647408 647409 647410 647411 647412 647413 647414 647415 647416 647417 647418 647419 647420 SP l SP l SP l SP l SP l SP l SP l SP l SP l SP l SP l SP l SP i SP i SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1486 j&ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VI-I DOSE: 100 MG/KG/DAY OBSERVATIONS DuPont-5386 647421 647422 647423 647424 647425 647426 647427 647428 647429 647430 647431 647432 647433 647434 647435 '1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1487 Gonspahy Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647448 647449 647450 647451 647452 647453 647454 647455 647456 647457 647458 647459 647460 647461 647462 .1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 SP SP SP SP SP SP SP SP SP SP SP SP SP SP SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1488 Company Sanitized. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ______ DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Px WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE ===---=-=-= -- =----- -- GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS =:= s sss s= s= sss sss-- =---- =: 647463 - 1 SP 647464 1 SP 647465 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647466 647467 647468 647469 647470 647471 647472 647473 647474 647475 647476 647477 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1489 CompanySanitised. Does notcontain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS ANIMAL NUMBER FEMALE RATS . DAYS ON TEST FATE ~-- = GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647478 647479 647480 647481 647482 647483 647484 - 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 ' 1490 Company Sanitized. Does notcontain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS 1491 CompanySanitized. Does notcontain TSCA CBI H-24516: Subcbronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design 1492 Dompany Sanitized. Dees not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS I MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS ======= = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = 647068 40 SD NO ABNORMALITIES DETECTED 647069 40 SD KIDNEYS - DILATATION, BILI 647070 647071 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647072 40 SD NO ABNORMALITIES DETECTED 647073 40 SD NO ABNORMALITIES DETECTED 647074 40 SD NO ABNORMALITIES DETECTED 647075 40 SD NO ABNORMALITIES DETECTED 647076 40 SD NO ABNORMALITIES DETECTED 647077 40 SD NO ABNORMALITIES DETECTED 647078 40 SD NO ABNORMALITIES DETECTED 647079 40 SD NO ABNORMALITIES DETECTED 647080 40 SD NO ABNORMALITIES DETECTED 1493 CompanySanitized. Does notcontain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 ADULTS MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH ~-- ----- -- ==ssrassss=-- OBSERVATIONS r--SSSS"""-- -------------------------- 647123 40 SD NO ABNORMALITIES DETECTED 647124 40 SD NO ABNORMALITIES DETECTED 647125 40 SD NO ABNORMALITIES DETECTED 647126 40 SD NO ABNORMALITIES DETECTED 647127 40 SD NO ABNORMALITIES DETECTED 647128 40 SD NO ABNORMALITIES DETECTED 647129 40 SD NO ABNORMALITIES DETECTED 647130 40 SD NO ABNORMALITIES DETECTED 647131 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647132 40 SD NO ABNORMALITIES DETECTED 647133 40 SD NO ABNORMALITIES DETECTED 647134 40 SD KIDNEYS - DILATATION, UNILATERAL, PELVIS 647135 .40 SD NO ABNORMALITIES DETECTED 647136 40 SD NO ABNORMALITIES DETECTED 647137 40 SD NO ABNORMALITIES DETECTED 647138 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS DuPont-5386 *-----s 1494 Company Sanitized. Does no! contain TSCA CBi H -2 4 5 16: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F1 ADULTS MALE RATS! . GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS = = = = = = = ======= ======================================= :=============! 647184 40 SD NO ABNORMALITIES DETECTED 647185 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647186 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647187 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 647188 647189 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, MINIMAL PELVIS 647190 40 SD NO ABNORMALITIES DETECTED 647191 40 SD NO ABNORMALITIES DETECTED 647192 647193 647194 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS 647195 40 SD NO ABNORMALITIES DETECTED 1495 Company SanWzed. Does not contain TSCA CBI II 11 II II II II tl II IIII II II II II II II II II II II II II 11 II II It H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS GROUP: VII-1 DOSE: 250 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH ===== OBSERVATIONS II II II II II II II II II II II II II 11 II II II 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 40 SD -NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD .NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED 40 SD NO ABNORMALITIES DETECTED DuPont-5386 1496 Conroanv Does no! contain TSOA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: II-1 DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH ===s:s==s= ----------------------------- S OBSERVATIONS II il II II II II 1! II It II It li il II II il II il II il II II It 647277 40 SD NO ABNORMALITIES DETECTED 647278 40 SD NO ABNORMALITIES DETECTED 647279 40 SD NO ABNORMALITIES DETECTED 647280 40 SD NO ABNORMALITIES DETECTED 647281 647282 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647283 647284 647285 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 647286 647287 647288 647289 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 1497 Company Sanitized. D oes not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5386 647326 40 SD NO ABNORMALITIES DETECTED 647327 40 SD NO ABNORMALITIES DETECTED 647328 40 SD NO ABNORMALITIES DETECTED 647329 40 SD NO ABNORMALITIES DETECTED 647330 40 SD NO ABNORMALITIES DETECTED 647331 40 SD NO ABNORMALITIES DETECTED 647332 40 SD NO ABNORMALITIES DETECTED 647333 40 SD .NO ABNORMALITIES DETECTED 647334 40 SD NO ABNORMALITIES DETECTED 647335 40 SD NO ABNORMALITIES DETECTED 647336 40 SD NO ABNORMALITIES DETECTED 647337 40 SD NO ABNORMALITIES DETECTED 647338 40 SD NO ABNORMALITIES DETECTED 647339 40 SD NO ABNORMALITIES DETECTED 647340 40 SD NO ABNORMALITIES DETECTED 647341 40 SD NO ABNORMALITIES DETECTED 647342 40 SD NO ABNORMALITIES DETECTED 1498 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. ADULTS FEMALE RATS GROUP: V I -1 DOSE: 100 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5386 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647-405 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1499 Company Sanitised. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS li ,11 II II O II II II II II CO II II II II II 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 1500 Company Sanitised. Does M l contain TSC GBI