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/4 & U 6 " /% ? 3 Results to Date from the PFOA Worker Health Study January 11,2005 Paul J. Bossert, Jr., Plant Manager Robert W. Rickard, Ph.D., Science Director of Haskell Laboratory for Health and Environmental Sciences Sol E. Sax, M.D., Chief Medical Officer E X H IB IT 1 Results to Date from the PFOA Worker Health Study Ammonium Perfluorooctonoate: Cross-Sectional Surveillance of Clinical Measures of General Health Status Related to a Serum Biomarker of Exposure and Retrospective Cohort Analyses in a Polymer Production Plant Summary To date, there are no human health effects known to be caused by PFOA; several statistical observations merit further study. Statistically significant associations are seen with serum PFOA levels and some serum lipid fractions, uric acid, and iron. These associations were only seen in those study participants with the highest serum PFOA levels, which were equal to or greater than 1000 ppb. DuPont, in collaboration with outside experts, is committed to conducting the studies that are necessary to understand the significance of these observations. The mmeles /s c e cz Purpose of Study Phase 1 Cross- Sectional Survey: Determine if there is a relationship of serum PFOA levels in current employees with respect to medical test results Phase 2 Historical Mortality Study: Determine if there is a relationship of past exposures to PFOA and any changes in frequencies and causes of mortality General Methods-- Phase 1 Cross-Sectional Survey Voluntary participation across all areas of the plant Cross-sectional design, that is, "snapshot" of both the exposure marker and the health outcome variables based on complete physical exam and clinical chemistries Exposure groups, by deciles, used to compare lowest to highest groups based on serum PFOA levels Statistical analyses for modeling relationships Status-- Phase 1 Cross-Sectional Survey 1,024 employees participated in the cross-sectional health survey All participants have received their individual serum PFOA levels and medical test results. About 60 parameters have been analyzed to date. Not all of the questionnaire data have been analyzed, but these analyses are underway. ill; The General Methods-- Phase 2 Historical Mortality Study Historical study of all causes of death among employees of Washington Works employees Covers period of about 50 years Compares frequencies and causes to U.S. national rates, West Virginia populations and the rest of U.S. DuPont Takes into account estimates of past exposures to PFOA Study is in progress. The ml C? Serum PFOA Levels By Work Assignment W ork Assignm ent Works in PFOA areas Previously worked in PFOA areas Number in Group 259 Serum PFOA (ppb) Median Min Max 490 17 9550 264 200 9 2590 Occasionally works in PFOA areas 160 Never assigned to PFOA areas 342 180 8 110 5 2070 963 Total Participants 1025 Jhe [ General Findings Nearly all of the parameters measured were within normal reference ranges and not associated with serum PFOA levels: - No correlation with liver function tests - No correlation with blood counts - No correlation with any cancer markers m easured- prostate, leukemia, multiple myeloma The mfntctefii:JvSde X/ General Findings Statistically significant but modest increases in some cholesterol fractions (total, LDL) and triglycerides at the highest concentrations of serum PFOA. Statistically significant but modest increases in uric acid and iron at the highest concentrations of serum PFOA. Notably, "good" cholesterol (HDL) was unaffected by serum PFOA levels. CRP levels (C-reactive protein, a possible risk factor for heart disease) were unaffected by serum PFOA levels. Mean adjusted lipid values for serum PFOA levels indicate a modest increase in highest decile (>1000 ppb) C H O LJO TA L by PFQA Quantile Sex=M, H eartm eds=N , UU 2004 Mean 1381823 Std Dev 32.345 350 " 187.0 28.787 205.623 39.434 199867 31099 6 .3 0 6 37.476 204835 32.836 200.871 30.472 199873 31022 206.097 36.740 214587 36.646 300 O 250 * I O200 1 1 1 II I IMI il II II 0 - /V LOG Chd Total vs LOGPFOA : WW 2004, Terms = LogPFOA ALC6 Where Sex=M, H eartm eds=8 5.8: SLOPE P-VALUE=0 5 . 7 : R--SQR=0.02 5.G: 5.5: Total Cholesterol = 240mg/dl *, ft* m * ft# ** / } * , .%#Jk , * - .. j 4 .U .ft -J - . ..H................ RXtLOG-Chol_Tot a I 5.4: 1 - v * ; tf 5. 3 ' ft ft Q 5.2 5.1 . '-'ite 'v ti-.v -':'? j 1% * . Ju> *V& ; I<t / 1 r 5.01 . i i . .! 4. 9 *ft* # ft# 4 . 8 j 10thdecile of serum PFOA >1000 ppb 4 . 7 i r i--I--i--I--I--i--I j i--i--i--I--I--I--I--r~i--I--I--I--I--r--f--I--j--I--I--I--I--I--I--I--I--I--i--j--I--j--n --i--i--i--rnr--r*i--|--i--r --i--I--j--I--I--I--i--I--I--I--i--I--I--r 3 4 5 G7 8 LOG PFOA /r- Overall Comparison of Male Washington Works Study Participants with the General US Population 30 25 Percentage of U.S. men, 20-70 years 20 .........of age, with total serum cholesterol............ levels greater than 240 mg/dL: 17 .8% 15 ' IO 5 O rzz--i LIZ\ 9 9S - II ID S Percentage The n Summary To date, there are no human health effects known to be caused by PFOA; several statistical observations merit further study. Statistically significant associations are seen with serum PFOA levels and some serum lipid fractions, uric acid, and iron. These associations were only seen in those study participants with the highest serum PFOA levels, which were equal to or greater than 1000 ppb. DuPont, in collaboration with outside experts, is committed to conducting the studies that are necessary to understand the significance of these observations. Plans for Further Work DuPont Medical, Epidemiology and Toxicology will work with medical and other scientific experts to design studies to answer remaining questions: Are these observations reproducible? Are similar associations seen in other worker populations? Is there a cause and effect? Is there a biological basis for these associations? ! T h e m ira c le s / s c ie n c e * /a Implications of Study Beyond Plant Not a general public health issue: Associations were only seen in an occupational setting. PFOA levels in general public extremely low. Not a consumer health issue: - DuPont research has demonstrated that no detectable serum PFOA levels would result from the use of consumer articles made with DuPont products 2004 Progress Report Reduction of C8 Emissions & Discharges at DuPont Washington Works <30 Emissions Reduction 2004 Progress Report Reduction of C8 Emissions & Discharges at DuPont Washington Works ..1999 I 2004 YE IReduction IJ Air Water jSwaWKaw^s35jwsuesi15waMcwS25Kr^iWM09waf^M9f7.vmKa^I! 185 1542 I 99.4% I 97.2% Total 86806 1 1727 111 98.0% 1 The miracles >/s c ie n c e .** <5 / Emissions and Exposure Reduction More than $21.5 million invested since 1988; another $6.2 million planned by 2006. DuPont is making recovery/recycle technology available to competitors. The mifades, f&dehcer' Results to Date from the PFOA Worker Health Study January 11,2005 Questions and Answers Paul J. Bossert, Jr., Plant Manager Robert W. Rickard, Ph.D., Science Director of Haskell Laboratories for Health and Environmental Sciences Sol E. Sax, MD, Chief Medical Officer Mean Std Dev 2.50 - 2.25 1736 0.198 URIC_ACID b y PFOA Quantile Sex=M, H eartm eds=B , UU 2004 1755 0209 1.822 0.179 1828 0.183 1820 0177 1.805 0.189 1810 0.205 18* 0205 1.777 0 *0 1.875 0.178 2.00 i 8 ir |HNI^4 4 i I HHSDC'175 3. .1 II 11 150 125 100 -----!--------------- 1---------------- 1----------------1----------------1---------------- 1----------------1----------------1----------------1 i W 18 W2 67 W3 97 W4 133 W 5 J 6 9 W6 210 W7 _266 W8 967 W9 537 W10 1040 grplbl Mean Std Dev 1410 0213 URIC_ACID b y PFOA Quantile Sex=F, Heartmeds=B, UU 2004 1.314 0.309 1495 0.285 1486 0.287 1542 0.195 1.533 0.192 1568 0.275 1552 0.242 Mean 1.508 Nobs 243.000 1.594 0.175 1.582 0.222 LO G LI RIC_AQ D vs LO G PFO A : W W 2004, Terms= LogPFOA BMI ALC4 Where Sex=M, Heartmeds=B 2 .G SLOPE P--VALUE= 0 2.5 R--SQR= 0.16 2.4 2.3 A 2.2 * ' . * / . *. 2.1 1 ` ------> i l . * H v 2.0 9 Qm 1.9 1.8 k* 1.7 RXJLG_U.RIC-ACID 1.G i :. i% V . ~ r / . . . . 1.5 I A" 1.4 i* 1.3 1.2 1.1 i i T i | - ri - i i 2 .0 2 .5 3 .0 r j i l- - | l -|- l- l ! i- j- i ,... , , , -, -, i i i i i' [ m 3 .5 4 .0 4 .5 5 .0 5 .5 G.O 'T 'i i i i i | i i i i [ r i i i ) i i r r f r r i i ') i i "i r G .5 7 .0 7 .5 8 .0 8 .5 9 .0 9 .5 LOG PFOA