Document XOQeNwwd83GNVNg1BDO62oJb4

AR226-3185 DuPont-4739 TRADE SECRET Study Title with OneH9-G0-2-eD4n6ae1yra6Gt:ioSanvuabRgceehprSrootnudidcuycTtiionoxnRicEaittvsyaluations Volume 2 of 5 Laboratory Project ID: DuPont-4739 Te st G u id e l in e s: OUP.SP.TESPA87H0.e3a1l0th0E(1ff9e9c8ts) Test Guidelines Author: Don A. Delker, Ph.D. S t u d y C o m p l e t e d o n : October 23,2001 P erform ing Laboratory: E.I. du Pont de Nemours and Company NEHleakwstkoaenrlklR,LoDaaebdlo,arwPa.taOorre.yB1fo9ox7r1H540e-0al0t5h0and Environmental Sciences W ork Request Num ber: Service Code N um ber^ H V * ) *S p o n s o r S t u d y N u m b e r :! Page 296 of 1537 Q m pm tiSanltzod. Does.notcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT | 0 | (mg/kg/day) | 1 1H 50 | 250 | 1000 1 IV 1 v i | VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY .DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, MEDIAN CLEFT. 11 11 1 | (10) I1 |641344 (10) | (10) ! do) I 641398 641240 641260 641244 641237 641245 641298 641251 641275 641249 641311 641269 641279 641257 641312 641292 641299 j641283 641313 641302 641300 j641290 641336 641362 641314 j641293 641355 641363 j641326 \ 641335 641361 j641375 641327 641384 641369 j641379 j641380 641396 \641398 641390 641283 641311 641302 641275 1 641327 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified JSt:41S* H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED ATROPHY. | LESION INCIDENCE (NUMERIC) 1 TREATMENT j (mg/kg/day) HO H 50 1 250 1 1 0 0 0 11 IV 1 VI 1 VIII 1111 1111 111 1 i (10) i II 11 1 11 do) 1 1 j641240j 1 641237 [6412451 1 641275 j641249j 1 641279 641283 j 1 641299 j641293 j 1 641300 j641384j 1 641314 641326 1 1 1 641327 1 1 1 641380 1 1 1 641390 j641257\ 11 16412901 j641335j j 1 1 j641344j 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified I.Does notcontain TSCAC 298 ri-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 1 0 | (mg/kg/day) 1 1 11 1 50 1 1 IV 1 250 1 1 VI DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED - FIBROSIS. 11 || | (10) 1 I1 11 641240) |641245| j641249j 641257 j j641283 j j641290j 641293 j 641335) 641384| 1| 641344| 11 1 | 1 1I 1 1 1 1 1 1 1 1 1 1 I 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1000 VIII (10) 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 CompanySanitized. Does notcontain TSCACBI 299 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 1 0 | (mg/kg/day) 1 1 11 1 50 1 1 IV | 250 | 1000 11 | VI | VIII DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED CYST, KERATIN. 11 11 | (10) | |641240| |641245| j641257j i641283 j 641290| j641293 i |641335| |641344j |641384 j 11 j641249 j 11 !1 i i i i i i i i i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 I (10) |641237 |641275 641279 641299 641300 641314 |641326 641327 j641380 |641390 1 1 Does no!contain TSCAC8I 300 O HH CompanySanitized. Does no!contain TSCAcell J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED * LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 (mg/kg/day) 1 50 250 1 1000 1 IV VI 1 VIII 111 11I! 11 1 (10) 1 1I j (10) 1 16412401 1 1641237 16412451 1 j641275 16412491 1 641279 |641257| 1 641299 j641283j 1 641300 j641290j 1 641314 641293 j 1 j641326 1641335j 1 641327 j641344j 1 641380 I641384 j 1 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 301 Ji H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- 11 1 1 LESIONS 1 1 1 1 DIGESTIVE SYSTEM 1 1 1 JEJUNUM 1 1 NO ABNORMALITY DETECTED 1 1 j 1 1 1 1 1 1 1 LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 o 1 (mg/kg/day) 1 j II ! 50 1 IV 11 11 11 1 (10) 1 j641240j j641245 j 16412491 |641257| 641283 j 1641290j 6412931 16413351 j641344j j641384j 11 1 250 1 1 VI 1 1000 1 1 VIII 11 1 1 1 1 (10) I1 1 1641237 1 j641275 1 j641279 1 641299 1 j641300 1 641314 1 j641326 1 641327 1 1641380 1 j641390 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanitized. Does notcontain TSCAC 302 11 1111 O HH 11 fi9*r>nySanitized.Does notcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNL(S9A0IS-NDTIAFCEYMAENAXDLPEONSROUANRT-NESEELOVISPATLLIANUSGATTIICNIODLNIEV)SIIDOUNASL ANIMALS AFFECTED- LESIONS 1 TREATMENT 1 (mg/kg/day) LESION INCIDENCE (NUMERIC) 50 1 250 1 1 0 0 0 11 IV 1 VI 1 VIII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED - 11 11 11 1 (10) 1 11 I1 1641240| |641245| j641249j j6412571 j6412831 1641290 j j641293 j j641335j j641344j 1641384| 11 1 1 1 1 I1 1 1 1 1 1 1 1 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 1 1 I (10) 1641237 641275 |641279 641299 j641300 641314 641326 641327 641380 1641390 1 303 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- 1 | LESION INCIDENCE (NUMERIC) j LESIONS I 1 | TREATMENT | 0 j (mg/kg/day) | j II | 50 | | IV | 250 | 1000 jj j VI | VIII i DIGESTIVE SYSTEM | ! CECUM | NO ABNORMALITY DETECTED i 11 1 1 1 1 1 1 1 | (IQ) 1 641240 1641245 641249 641257 641283 641290 641293 641335 641344 641384 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 | 1 1 1 1 1 1 1 1 1 1 (10) 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 fiSHlpaifSanitized. Does notcontain TSCACBI 304 O HH CompanySanRzed. Does no! TSCACTS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED | LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 (mg/kg/day) 1 50 1 250 1 1000 1 IV 1 VI 1 VIII 111 11 1111 1 (10) 1 tI 1 1 (10) 1 1111 16412401 1 641237 |641245| 1 641275 1641249 J 1 641279 j641257 j 1 j641299 j641283 1 1 641300 j641290j 1 641314 641293 j 1 641326 1641335j 1 641327 j641344j 1 641380 1641384) 1 j641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 305 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED - LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 (mg/kg/day) 1 HH O 50 1 250 1 1000 11 IV 1 VI 1 VIII 1111 11 I1 1 (10) 1 I1 1I 1 (10) 1 1111 |641240| 1 1641237 16412451 1641249] 16412571 1 j641275 1 641279 641299 16412831 1 641300 |641290| 1 641314 641293 j 1 641326 j641335 j 1 j641327 j641344j 1 641380 j641384 j 1 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- If I i 8-5 > I ! | LESION INCIDENCE (NUMERIC) 1 O 111 1 11 LESIONS 1 TREATMENT 1 (mg/kg/day) HH 50 IV DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED ' 11 II 11 1 (10) 1 II 11 16412401 |641245| j641249j j641257 i641283 j j641290j 641293 j j641335 j j641344j j641384\ 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 250 1 1 VI 1 I 1 I1 1 1 1 1 1 1 1 1 1 1 1 1 1 1000 j VIII 1 (10) 1 1 641237 j641275 641279 j641299 j641300 641314 j641326 641327 j641380 1641390 1 307 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- I LESION INCIDENCE (NUMERIC) LESIONS 1 TREATMENT 1 0 1 (mg/kg/day) 1 1 1 11 1 50 1 1 IV 250 1 1000 1 11 VI 1 VIII 1 URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED ! NEPHROPATHY, CHRONIC PROGRESSIVE. INFLAMMATION, SUBACUTE/CHRONIC. HYDRONEPHROSIS, UNILATERAL. 11 1I 1 (10) 1 11 11 16412401 1641245 i 1641249| |641257| j641283 j j641293 j j641344j 16413841 11 |641290| 11 1641335 1 11 11 11 1 (10) 1 jj 1641237 1 j641275j j641279j j641299 i j641300j j641314j j641326j 1641327j 1641380 j 16413901 11 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does no!contain TSCACBI 308 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) LESIONS TREATMENT 1 0 (mg/kg./day) 11 1 11 1 50 11 I IV URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED 11 11 11 1 (10) 1 11 11 |641240| 641245] i641249 j j6412571 j641283 j j641290j 1641293 j j641335j 1641344j j641384j 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1I 250 1 1 VI 1 1 1 1 11 1 1 1 1 1 1 1 1 1 1 1 1 1000 1 1 1 VIII 1 1 1 1 (10) 11 1641237 1641275 641279 j641299 j641300 \641314 641326 641327 1641380 641390 1 --'H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS | TREATMENT | (mg/kg/day) 1 | LESION INCIDENCE (NUMERIC)| -------- | 10 1 1 11 1 50 1 1 IV | 250 1 \ VI | 1000 \ 11 1 VIII 1 RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED - INFLAMMATION, SUBACUTE/CHRONIC. I1111 1I111 11111 | (10) | II 11 111 i (10) 1 11 11 1641240| 1 |641237| 1641245 j 1 j641279 j |641249| i j641299 j j641257j 1 j641300 j j641283 j 1 |641314 j j641290j 1 |641326 j 641293 j 1 j641327j j641335j 1 j641380j j641344j 1 i641390 j j641384j 1 1 I 1 1 1 641275| 1111i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Dees no!contain TSCACBS 310 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED I LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 (mg/kg/day) 1 HO H 50 1 250 1 1000 11 IV 1 VI 1 VIII 11 1111 1111 1 do) 1 1 1 (10) 11 I1 I1 1 16412401 1 1641237 |641245| 1 j641275 j641249 1 641279 j641257 j 1 1641299 j641283j 1 641300 16412901 1 641314 1641293 j 1 641326 j641335 j 1 641327 j641344j 1 641380 641384 1 1641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified I ,1-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED - 1 TREATMENT 1 (mg/kg/day) 1 1 HH O 111111 LESION INCIDENCE (NUMERIC) ---------------------- 1 50 1 250 1 1000 j IV 1 1 i 1 (10) 1 1641240 641245 641249 j641257 641283 641290 641293 641335 j641344 641384 1 1 1 VI 1 1 ! 1 1 1 1 1 1 ! 11 1 VIII 1 1 11 11 11 1 (10) 1 11 11 6412371 i641275j j641279 j j641299j j641300j j641314j j641326j j641327j j641380 j 6413901 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does no! contain TSCA 312 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIIONCNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) I1 O HH LESIONS | TREATMENT | (mg/kg/day) 50 | 250 1 IV 1 VI 1000 | VIII | RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED - INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM. 1j 1 11 | (10) (10) ! do) (10) | 11 |641240 641260 641244 641279| |641245 641298 641292 641326j 641249 641311 641302 641257 641312 641363 641283 641336 641375 641290 641355 641379 j641293 641361 |641335 641396 |641344 641384 1 641269 641300| 1 641269 1 641313 |641251 641237] 1 641369 641269 641275j 1 641362 641299j 1 641398 641300j 1 641314j 1 641327 j 1 641380j 1 641390 j Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ! f H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICNONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED ' CARDIOMYOPATHY. . LESION INCIDENCE (NUMERIC) | TREATMENT o 1 50 | 250 | 1000 | (mg/kg/day) 111 1 II | IV 1 VI | VIII 111 II 1 (10) j | (10) 1!1 111 6412491 1 641237 641257| 641275 641283 j 1 641279 641290| 1 641299 641293| 1 641300 641335| j641314 641344) 641384] 1 |641326 641327 1 1 j641390 641240| j641380 641245| 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified TSCACB! 314 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC)| LESIONS TREATMENT 1 0 (mg/kg/day) ii n 1 50 ii 1 IV 250 1000 1 11 1 VI VIII 1 CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED 11 11 11 1 GO) 1 i1 1i 16412401 |641245| j641249j 1641257 j641283 j j641290j j641293j i641335 j i641344j 641384j 11 (10) 1 6412371 641275 6412791 641299j 641300 641314 j 641326j 641327 j 6413801 6413901 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified f tscacbi 315 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- 11 1 1 LESIONS 1 1I1 1 LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 1 111 SPLEEN 1 NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 1 1 1 PIGMENT INCREASED. 1 | TREATMENT | (mg/kg/day) 1 | LESION INCIDENCE (NUMERIC)| 1 10 1 | II 1 50 1 | IV | 250 1 VI 1000 j 1 VIII I ______ 1 11 11 11 | (10) | iI 1! |641240| |641245| j641257j 641283 j j641290 j j641293j [641335 j 641344| |641384j 11 641249| 11 1 1 1 1 |1 1 1 1 1 1 1 1 1 1 1 1 1 I (10) 1 641237| 641275j 641279| 641299j 641300j 641314| 641326j 641327j 641380| 641390 j 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H OH *** *** Sm" " * " 0. conte,,, TSCACB, ^ "" ' 'J" H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED | LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 (mg/kg/day) 1 50 1 250 1 1000 1 IV 1 VI j v i n 1111 1111 1111 1 (10) 1 1 1 (10) 1 1111 16412401 1 641237 641245 I 1 641275 1641249j 1 641279 j641257 j 1 641299 j641283 j 1 641300 j641290j 1 641314 641293 j 1 641326 j641335j 1 641327 j641344j 1 j641380 6413841 1 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 317 vj H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICNONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED - | LESION INCIDENCE (NUMERIC) | TREATMENT 1 0 j (mg/kg/day) 1 1 11 1 50 1 1 IV | 250 | 1000 11 1 VI | VIII 11 11|1 1111 I (10) 1 I (10) i1 1 111] |641240| 1 \ 641237 |641245 j 1 641275 j641249 j 1 641279 [641257| 1 641299 641283 j 1 641300 |641290 j 1 641314 j641293 j 641326 j641335j | 641327 |641344j 1 641380 j641384j 1 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified f. Does no!contain TS^ans 318 H OH .CompanySanitized. Does notcontain ten rtj^i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIIONCNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED - | LESION INCIDENCE (NUMERIC) | TREATMENT | (mg/kg/day) 1 50 | 250 1 1000 11 IV 1 VI | VIII 111 111 111 | (10) | 1 I (10) 11 II I1 |641240| 1 |641237 [641245 j 1 641275 |641249| 1 641279 641257| 1 641299 641283| 1 641300 j641290j 1 |641314 641293 j 1 |641326 |641335j 1 |641327 j641344 j 1 641380 641384| 1 j641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 319 -- ............... .r ...................... rf-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- I LESION INCIDENCE (NUMERIC)| HH O 11 LESIONS | TREATMENT 1 (mg/kg/day) 1 50 | 250 | 1000 I 1 11 IV 1 VI | VIII I LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED * w i 8a. 111 |11 ! do) ! |641240| j641245 j |641249| j6 4 1 2 5 7 j j6 4 1 2 8 3 j j6 4 1 2 9 0 j j641293 j j641335j j6 4 1 3 4 4 j |6 4 1 3 8 4 j 11 111 1 I (10) 1 11 1 641237| 1 |6 4 1 2 7 5 j 1 j641279j 1 j64 1 2 9 9 j 1 j64 1 3 0 0 j 1 641314| 1 i6413261 1 j6 4 1 3 2 7 j 1 j641380 j 1 |6 4 1 3 9 0 j 11 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does not contain TSCACB1 320 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED - | LESION INCIDENCE (NUMERIC)| | TREATMENT 1 o j (mg/kg/day) 1 1 1 11 1 50 1 1 IV 1 250 1 1 VI 1000 I VIII I 11 11 I1 O) I1 11 |641240| |641245| j641249j 641283 j i641290 j j641293j j641335j j641344 j |641384 j 11 1 | 1 1 1 1 1 1 1 1 1 1 1 1 (10) 1 641237 | 641275j 641279j 641299\ 641300 j 641314j 641326j 641327 j 641380 j 641390j Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Sanitized. Does notcontain TSCACBS 321 ^J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIIONCNDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED - HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. | LESION INCIDENCE (NUMERIC)| ----------------------------------------- | | TREATMENT | 0 | (mg/kg/day) j | | II j 50 j j IV | 250 j | VI | 1000 | | | VIII j --- 1 111 | (10) I (10) I (10) 1!1 (10) | 1 1 |641240641260|641269 I |641249641311641363 1 641257641336641379 1 641283641361641398 1 641293641396| I j641335j j 1 j641384j j I j j 641302 641237 | I 1641375 641279j 111 111 111 111 641299j 641326j 641327| 641380j 641390 j |641245|641298|641244 641237 j 641290641312641251 641275j 641344641313641292 641279j j 641355)641302 641299j j 641369|641362 641300j j j 641375 641314j 111 641326| Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanitized. Does notcontain TSCACBI 322 sJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations JBp w DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSAISNTIFCEMANADLENROANT-NSELOISPLTAINSGTTINCDLIEVSIIDOUNASL ANIMALS AFFECTED- (90-DAY EXPOSURE EVALUATION) I LESIONS ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. LESION INCIDENCE (NUMERIC) TREATMENT 1 0 (mg/kg/day) 1 11 111 50 1 IV 1 250 I1 1 VI 111 1000 1 1 VIII 1 GO) (10) I (10) (10) 641327 641380 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does notcontain TSCAC 323 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSAISNTIFCEMANADLENROANT-NSELOISPTLIANSGTIICNDLIEVSIIDOUNASL ANIMALS AFFECTED- (90-DAY EXPOSURE EVALUATION) | LESION INCIDENCE (NUMERIC) LESIONS 1 TREATMENT 1 o 1 (mg/kg/day) 1 1 1 II 1 50 1 1 IV 1 250 1 1 VI 1 1000 1 1 VIII ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED 11 11 1111 1 (8) j 1 1 (2) I1 I1 1641240| 1 641299 1641245| 1 641314 1641283| 11 |641290| 11 j641293j 1 1 j641335j 1 j641344j 1 j641384j 1 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanitized. Does notcontain tsc CEI 324 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) o H 1 50 1 1 IV 1 250 ! VI 1 1000 1 1 VIII 11 11 1 (10) 1 11 641240| 1 1 (10) 1641237 6412451 1 1641275 6412491 1 641279 641257 1 1 j641299 6412831 1 j641300 6412901 1 641314 6412931 1 641326 6413351 1 641327 641344] 1 641380 641384| j641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified I.Does notcontain TSCACBI 325 O HH Company SanWzed. Does notconfafn TSCACBi P m'-- ) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS 1 TREATMENT 1 (mg/kg/day) 1 50 1 250 1 1000 11 IV 1 VI 1 VIII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED ' . 11 III 111 1 (10) 1 II 1 1 (10) 1 11 1 1 |641240| 1 641237 |641245| 1 641275 j6412491 1 641279 j641257j 1 j641299 641283 j 1 j641300 j641290j 1 j641314 j641293 j 1 641326 j641335j 641327 j641344 j 1 641380 j641384j 1 641390 111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 326 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSAISNTIFCEAMNADLENROANT-NSELOISPTLIANSGTIINCDLIEVSIIDOUNASL ANIMALS AFFECTED- (90-DAY EXPOSURE EVALUATION) 1 1 LESIONS 1 1 1 I NERVOUS SYSTEM 1 1 1 SPINAL CORD 1 1 NO ABNORMALITY DETECTED 1 1 1 1 1 j 1 i 1 1 TREATMENT I (mg/kg/day) 1 1 LESION INCIDENCE (NUMERIC)1 ...... I 1o 1 1 II 1 50 1 1 IV 1 250 1 1 vi 1 1000 1 11 1 VIII 1 11 11111 11111 1 GO) 1 11 I1 1I! 1 GO) 1 j1 1641240j 1 1641237| |641245| 1 6412751 j641249j 1 j641279j 11641257 j 1 6412991 j641283j j641300 j j641290j 1 j641314 j j641293j 1 1641326 j i641335I 1 641327) j641344j 1 j641380 j (641384 j 1 j641390 j 11111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified oes nocontain TSCA 327 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS NERVOUS SYSTEM I TREATMENT I (mg/kg/day) LESION INCIDENCE (NUMERIC)| I0 |50 II IIV ! I I|250 | 1000 | IVI I VIII I SCIATIC NERVE NO ABNORMALITY DETECTED (10) 1 !1 6412401 641245| 641249| 641257| 6412831 6412901 641293| 6413351 6413441 6413841 i I1 1 1 1 1 1 1 1 1 1 1 (9) 641237 641275 641279 641299 641300 641314 641326 641327 641390 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Sanitized. Does notcontain TSCCB) 328 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- 1 1 1 LESIONS 1 111 1 MUSCULAR AND SKELETAL SYSTEM 1 1 I SKELETAL MUSCLE 1 1 NO ABNORMALITY DETECTED 1 1. 1 1 1 1 1 1 1 1 | TREATMENT | (mg/kg/day) 1 | LESION INCIDENCE (NUMERIC)| I1 1 o | 50 | 250 | 1000 j 1 1 II 1 1 IV 111 | VI 1 VIII 1 ____ __ _l 11i 111 11111 | (10) | 1 | (10) 1 11 I! 1I |641240| 1 |641237| |641245| 1 j641275j j641249i 1 641279) j641257| 1 j641299j 641283| 1 j641300| |641290j 1 j641314j 641293| 1 641326] j641335j 1 |641327 j j641344j 1 641380| j641384 j 1 j641390| 11111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanitized. Doesnotcontain TSCAC1 329 O> in h O HH e0mpmy San,,bl- Doss no!contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) LESIONS TREATMENT (mg/kg/day) 250 | 1000 1 VI I VIII MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED 11 I (10) 1 11 11 |641240| |641245 I |641249| |641257| 641283 j |641290 j j641293 j 641335) i641344 j 641384| 11 this tissue The absence of a number indicates the lesion specified was not identified 1 1 1 I (10) 11 |641237 641275 641279 641299 641300 641314 j641326 j641327 641380 j641390 1 330 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIICONNDL)IEVSIIDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 1 o | (mg/kg/day) 1 1 1 II | 50 1 1 MUSCULAR AND SKELETAL SYSTEM || STERNUM NO ABNORMALITY DETECTED - 11 | (10) | 11 |1 |641240| |641245| |641249| |641257| 641283\ |641290| j641293j 641335| |641344| j641384j 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 250 | 1000 VI | VIII | | GO) |641237 j641275 641279 j641299 j641300 641314 641326 \ 641327 641380 |641390 1 Sanitized. Does notcontainTSCACBf 331 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) 1 1O LESIONS TREATMENT (mg/kg/day) H H 50 1 250 1 1000 1 111 IV 1 VI 1 VIII 1 REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED 1111 11111 11111 1 GO) 1 1 i (10) j j! I1 1 16412401 1 16412371 1641245 j j641275j 1641249 1 1 j641279j |641257| 1 1641299j 641283| 1 641300) j641290j 1 i641314 i j641293j 1 j641326j 16413351 1 6413271 1641344j 1 1641380| j641384\ 1 16413901 11111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINOCNDL)IEVSIIDOUNASL ANIMALS AFFECTED- I O0 1 3 a O ! a 3as 3 a f! I s. LESIONS REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED DILATATION, LUMEN. 1 LESION INCIDENCE (NUMERIC) TREATMENT 1 o (mg/kg/day) I1 1 II 1 50 I1 1 IV 1 250 1i 1 VI 1 1000 11 1 VIII 111 111 111 1 (10) 1 1 1 j1 ! do) 1 1 16412401 1 641279 16412451 1 641300 1641249 1 1 j641314 16412571 1 641326 |641283| 1 641327 j641290j 1 641380 i641293j 1 j641390 j641335 j 1 1 i641344 j 1 j641384 j 1 1 1 j641237 1 641275 ! ! 1 641299 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 333 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYMANEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- LESIONS REPRODUCTIVE SYSTEM LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 0 1 (mg/kg/day) 1 1 1 II 1 50 1 1 iv 1 250 1 1 VI 1 1000 1 1 VIII 1 MAMMARY GLAND (FEMALE) Ii | NO ABNORMALITY DETECTED I I I 1 1 (10) 1 I1 I1 641240] |641245| i641249 i i641257j j641283 j j641290j j641293 j 6413351 1641344j 1641384j 11 1I 1 1 1 1 1 1 1 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (10) 1 j 16412371 j641275j j641279j j641299j 1641300 j 641314) 1641326j j641327j j641380j j641390j 11 Sanitized. Does notgontfln TSCACSi 334 l 1 1 1H 1O H 1 1 Company Sanitized. Does notcontain TSCACBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED ' 1 TREATMENT 1 (mg/kg/day) 1 50 IV 11 11 1 (10) 1 I1 I1 |641240| |641245| 641249| j641257 j 1641283 1 j641290j 16412931 1641335j j641344j 641384| 11 1 250 1 1 VI 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1000 1 VIII \ (10) 1 6412371 641275j 641279j 641299j 641300 j 6413141 641326j 641327j 641380j 641390j Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 335 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSA(9IS0NT-DIFCAEYAMNEAXDLPENOROSUANRT-NESEELOVISAPTLLIAUNASGTTIIINCONDL)IEVSIIDOUNASL ANIMALS AFFECTED- 1 | LESIONS 1 1 | TREATMENT | (mg/kg/day) 1 | LESION INCIDENCE (NUMER..I...C...)| |0 | 1 II | 50 | 1 IV 1 250 1 1 VI | 1000 1 11 1 VIII 1 | SPECIAL SENSES SYSTEM | EYE(S) WITH OPTIC NERVE 11 | NO ABNORMALITY DETECTED j l l l 1 l l 1 | OPTIC NERVE NOT PRESENT. j FOLD/ROSETTE, RETINAL. 1 1 1 111 | GO) | 1 | (10) 1 11 I1 I1 j \ |641240| 1 |641237 1 |641245| 1 j641275j i641249 i 1 j641279j j641257| 1 j641299j 641283| j641300 | j641293 j 1 j641314j j641335j 1 j641326j |641344j 1 j641327j 641384| 1 \ 641380\ 1 1 1 j641390| j641335\ 1 j641390j |641290j 1 1 1 11111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified j ,j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENAMTNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS DIGESTIVE SYSTEM | TREATMENT 1 0 | (mg/kg/day) 1 1 1 11 1 1 50 1 1 IV 1 LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, MEDIAN CLEFT. | GO) | I 1I 1I |641253| j641266 j j641281j |641294| j641325 j j641331j j641359j j641364 i 641383| 641400| j641266j 641383 j j641400j 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 250 1 1 VI 1 | 1 1I 1 | 1 1 1 1 1 1 1 1 1 1 | 1 1 1 1 | 1000 1 | VIII 1 1 1 I go) 1 1 641356 641366 641234 641256 641282 j641352 641366 641377 641385 641387 j641399 | |641377 1 1 1 Company Sanfeed. Does no!contain TSCACBI 337 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ ___________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED ESOPHAGUS NO ABNORMALITY DETECTED I STOMACH NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) | TREATMENT 1 0 | (mg/kg/day) 1 1 1 II 1 50 1 1 IV | 250 1 1 VI | 1000 1 | VIII 111 1II1 1111 1 1I 1j 1 (1) 1 1111 1 1 1 |641356 1 1111 1 1 1 | (1) 1 11 1 11 641356 1 1111 1 1I 1l | (1) i 1111 1 1 1 641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does no8eenaln TSCACBI 338 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- 1 1 | LESIONS ! | DIGESTIVE SYSTEM i 1 | DUODENUM | 1 | NO ABNORMALITY DETECTED 1 i | JEJUNUM 1 1 | NO ABNORMALITY DETECTED I 1 | ILEUM | AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. | TREATMENT | (mg/kg/day) 1 1 LESION INCIDENCE (NUMERIC)| 1l 1 0 | 50 250 1 1000 1 11 1 II | IV I1 VI 1 VIII 1 - --I 11 11 11 11 I1 I1 11 I1 I1 11 11 I1 11 11 I! 111 i 11 1i 1i 11 11 11 1 (1) 1 I1 1 1641356| I1 1 (1) ! I1 | 1641356| I1 j 1 (1) | II j 1641356| 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS DIGESTIVE SYSTEM CECUM AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. COLON AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. RECTUM NO ABNORMALITY DETECTED I LESION INCIDENCE (NUMERIC)| | TREATMENT | 0 | (mg/kg/day) j | | II | 50 j | IV | 250 j j VI 1000 VIII 111 I11 111 !1 i1 !1 lll 1i1 111 ii i1 ii 111 >i1 1i i1 i1 (1) 641356 (1) 641356 (1) 641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS j DIGESTIVE SYSTEM | TREATMENT 1 (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 1 50 1 250 1 1000 111 II 1 IV 1 VI 1 VIII ! SALIVARY GLANDS I | NO ABNORMALITY DETECTED (1 ) 641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ISOVOSJLUiejuoo 341 i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC)| LESIONS | TREATMENT 1 0 1 (mg/kg/day) 1 1 1 II | 50 1 1 iv | 250 1 VI 1 1000 1 1 VIII | URINARY SYSTEM I I | KIDNEYS I | NO ABNORMALITY DETECTED I | URINARY BLADDER I | NO ABNORMALITY DETECTED I U) | 6 4 1 3 5 6 |I I (1 ) | 6413561 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Does notcontain TSCACBI 342 -J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENAMTNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 1 0 j (mg/kg/day) 1 1 1 II 1 50 1 1 IV RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED TRACHEA NO ABNORMALITY DETECTED PHARYNX/LARYNX NO ABNORMALITY DETECTED 1 1I 11 1I 1 11 11 11 11 1 1 11 11 11 11 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 250 1 1 VI 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 | 1000 1 | VIII 1 1 1 1 (1) 1 |641356 1 | (1) 1 641356 1 i g) 1 641356 1 notcontain Tbca ci 343 1 11 1H 1I O H t pSMPMy Sanitized. Doesnotcontain Tftr* J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS RESPIRATORY SYSTEM 1 TREATMENT 1 (mg/kg/day) 1 1 50 IV 1 NOSE NO ABNORMALITY DETECTED - 11 1 (10) 1 11 1I 16412531 1641266 J |641281| 1641294j i641325 j j641331j j641359j j641364j 6413831 j641400j 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 250 1 1 VI 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1000 VIII (10) 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 > ,,3 344 n iM n W ia ilIIIir Iiirr T u rrrr- r ' __ - - . .... J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS CARDIOVASCULAR SYSTEM | LESION INCIDENCE (NUMERIC) 1 TREATMENT 1 0 1 (mg/kg/day) 1 1 1 II 1 50 1 1 IV 1 250 1 1000 1 1 VI 1 VIII HEART NO ABNORMALITY DETECTED CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED | | | | (1) I I II | | | |641356 I I I1 I I II I I II I I II | j | | (1) I I I 1641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanitized Does notcontain TSCACB 345 .J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- f | I 1 LESION INCIDENCE (NUMERIC)| LESIONS | TREATMENT I 0 | (mg/kg/day) 1 1 II 1 50 1 1 IV 1 250 1 1 VI | 1000 | 11 | VIII | LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED THYMUS NO ABNORMALITY DETECTED MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED 111 111 11111 1 1 1 1 (1) 1 IIIf1 11111 1 1 1 |641356| 11 1i 1111 1 1 1 1 1 (U | 1J1 111 1 1 1 641356| l11 I 111 i 1 1 1 i (U i l11 1 I 1111i 1 1 1 | 641356j 111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 346 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC)| LESIONS | TREATMENT 1 0 | (mg/kg/day) 1 1 1 II 1 50 1 1 IV LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED BONE MARROW NO ABNORMALITY DETECTED 1 || 11 11 11 11 11 11 11 11 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion'specified was not identified 1 250 1 1 VI 1 1 1 1 1 1 1 1 1 1 1 | 1000 I 1 VIII 1 1 1 1 (1) 1 641356 1 j (1) 641356 1 r) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 1 o | (mg/kg/day) 1 1 1 11 | 50 1 1 IV ! 250 i VI ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. || I 11 11 1! | (10) | 1I 1i |641253| 641281| 641294] j641331j 11 11 11 11 11 641266] 641325j j641359j |641364 j \ 641383 j j641400j 11 1I i i i ii 1 i1 i i i i i i i i i i i i i i i i i i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1000 j VIII 1 (1) .1 641356| (10) | 641352| 641366j 641234| 641282| 641377 j 641387| 641399 j 641234j 641256j 641282 j 641377j 641385] 641387j 641399j 641356 j &?PanirSanitized. Does notcontain TSCACB 348 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIANCTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS ENDOCRINE SYSTEM | LESION INCIDENCE (NUMERIC) | TREATMENT | 0 | 50 |250 |1000 | (mg/kg/day) j | I I | j IX I IV |VI jVIII PARATHYROID GLANDS NO ABNORMALITY DETECTED ADRENAL GLANDS NO ABNORMALITY DETECTED (1 ) 641356 (1 ) 641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS NERVOUS SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 11 50 1 250 1 11 1000 111 II 1 IV 1 vi 1 VIII BRAIN MIXED GLIOMA [M]. SPINAL CORD NO ABNORMALITY DETECTED SCIATIC NERVE NO ABNORMALITY DETECTED (1 ) 641356 ( 1) 641356 (1 ) 641356 [M] Malignant tumor Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED FEMUR/KNEB JOINT NO ABNORMALITY DETECTED STERNUM NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC)| TREATMENT 1 0 (mg/kg/day) 1 1 II 1 50 1 IV 1 250 1 I VI 1 1000 1 1 VIII (1) I 641356 G) I 641356 II I( 1 ) 6413561 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 'J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENMATNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- | LESIONS | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) | 1 1 0 | 50 | 250 | 1000 I 1 1 II 1 | IV 1 I VI 11 1 VIII 1 | REPRODUCTIVE SYSTEM 1 1 | OVARIES | NO ABNORMALITY DETECTED | UTERUS 1 j NO ABNORMALITY DETECTED 11111 |111 1111 1 1 1 1 1 (1) 1 1111 1 1 1 1 1641356 j 11111 1 1 1 1 U) 1 1111I 1 1 1 1641356| 111ll Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified i i wl9,any Sanitized. Does notcontain TSCACBI 352 24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOP(NOLSNAEISN-TMIFCOENAMTNAHDLRENECROOANVT-NESRELYOISPETLVIAANSLGTUIIACNTDLIOIEVNSI)IDOUNASL ANIMALS AFFECTED- LESIONS SPECIAL SENSES SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT | 0 (mg/kg/day) j II | 50 j IV EYE(S) WITH OPTIC NERVE AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. (1 ) 641356 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNL(SA3-ISMNTOIFCNETMAHNARDLEENCOROVANET-NRSYELEOIVSPTALILANUSGATTIICNIODLNIEV)SIIDOUNASL ANIMALS AFFECTED- LESION INCIDENCE (NUMERIC) LESIONS TREATMENT | 0 50 250 1 1000 (mg/kg/day) | 1 II IV VI 1 VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, FOCAL. 1 1 (5) (5) (5) 1 11 641241 641321 6412621 (5) 641309 6413721 641285 641247 641232641259 641288 641319 641305641264 I641394 641340 6413821641278 641391 1641301 641395 641247 |641259 641395 641382 j 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ! 0fi*PrSanitized Doesnocontain TSCAC 354 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNLSAISNTIFCEMANADLENROANT-NSELOISPTLIANSGTIINCDLIEVSIIDOUNASL ANIMALS AFFECTED- (3-MONTH RECOVERYEVALUATION) LESIONS RESPIRATORY SYSTEM TREATMENT (mg/kg/day) HO H LESION INCIDENCE (NUMERIC) 50 1 250 1 1000 1 111 IV 1 VI 1 VIII 1 1 NOSE 1 (5) (5) [ (5) (5) ! NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. ATROPHY, UNILATERAL, NASAL GLANDS. |641241 641247 1641232 6412591 641309 641321 641262 i641264 i 641340 641305 641278| 641391 641372 641301j 641382 641395j 1641285 641319 641288 641394 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 42 (CONTINUED) MICROSCOPIC OBSERVANTEIOOPNL(SA3-ISMNTOIFCNETMAHNARDLEENCOROVANET-RNSYELEOIVSPTALILANUSGATTIICNIODLNIEV)SIIDOUNASL ANIMALS AFFECTED- LESIONS ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. | LESION INCIDENCE (NUMERIC) | TREATMENT | 0 | (mg/kg/day) | 1 ! II 50 | 250 1 IV 1 VI 1000 VIII 1 1 I (5) I 1 641285 (5) | (5) I 1 (5) j641305 641259 641288 I 641301 I 641264 |641241 641247 641232 641264 641309 641319 641262 641278 641394 641321 641372 641395 1 641340 641382 1 641391 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 43 MEAN BODY WEIGHOTSF PAiNMDABLOEDRYATWSEIGHT GAINS (grams) GROUP DOSE (mg/kg/day) N TEST DAY3 71 78 85 92 100 1-0 III-O V-0 VII-0 0 50 250 1000 20 20 20 20 MEAN BODY WEIGHT (grams) 545.2 (60.4)*> 558.9(63.3) 570.7(65.7) 582.3(66.8) 591.7(70.6) 543.0(41.7) 551.9(46.1) 561.7(42.6) 570.7(44.3) 578.8(43.3) 535.4(42.5) 548.4(48.1) 556.4(49.1) 567.8(53.1) 576.4(54.6) 489.8(50.6)* 502.3(54.4)* 506.7(52.6)* 519.6(52.3)* 526.7(55.0)* GROUP DOSE (mg/kg/day) N TEST DAYS3 1-0 III-O V-0 VII-0 0 50 250 1000 20 20 20 20 MEAN BODY WEIGHT GAIN (grams) 71-78 78-85 85-92 92-100 13.7( 7.4)i> 11.8( 4.7) 11.6( 8.9) 9.4( 9.4) 8.9(16.7) 9.8(10.1) 9.0(14.7) 8.1( 8.7) 13.0(11.0) 8.0 ( 7.7) 11.3( 8.3) 8.7( 9.6) 12.5( 8.6) 4.4(14.8) 12.9( 6.9) 7.1( 9.3) 71-100 46.5(19.0) 35.8(15.9) 41.0(16.8) 36.9(14.2) a Cohabitation period = Test days 69-92. b Standard deviation is reported in parentheses. * Statistically significant difference from control by One-Way Analysis of Variance and Dunnett's tests; (p < 0.05). 357 no!en"9'1- *kji H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 44 MEAN BOODF YPiWFEEMIGAHLTESRAANTDS BDOUDRYINWGEGIGESHTTAGTAIOINNS (grams) GROUP DOSE (mg/kg/day) N GESTATION DAY 0 7 14 21 II-O 0 16 IV-0 50 18 VI-0 250 13 MEAN BODY WEIGHT (grams) 306.0(23.0)3 335.3 (24.6) 366.6(29.8) 456.6(27.8) 310.0(28.0) 336.8(31.5) 366.0(34.9) 461.6(39.5) 299.9(21.7) 325.5(22.9) 356.9(28.8) 450.7(28.0) VIII-0 1000 18 295.3(26.9) 317.9(28.6) 350.4(32.2) 445.1(44.1) GROUP DOSE (mg/kg/day) N II-O 0 16 IV-0 50 18 VI-0 250 13 VIII-0 1000 18 GESTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 29.3( 7.9) 31.3( 8.6) 90.2(12.9) 26.8( 8.3) 29.2( 6.1) 91.6(14.6) 25.6( 6.6) 31.4( 7.2) 92.1( 7.3) 22.6( 7.6) 32.5( 6.0) 93.9(14.7) 0-21 151.7(17.8) 148.8(22.4) 148.3(14.4) 149.0(20.7) a Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). CompanySanitized. Does notcontain TSCACBS 358 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 45 MEAN BOODF YPiWFEEMIGAHLTESRAANTDS BDOUDRYINWGELIAGCHTTAGTAIOINNS (grams) GROUP DOSE (mg/kg/day) N LACTATION DAY 0 7 14 21 II-O 0 18 IV-0 50 18 VI-0 250 13 MEAN BODY WEIGHT (grams) 349.6(28.5)3 347.6(24.1) 364.8(24.0) 349.6(23.0) 350.5(34.1)^ 344.4(26.7) 362.1(26.6) 347.6(25.5) 337.7 (29.0) 343.6(26.3) 356.4(23.9) 344.8(22.5) VIII-0 1000 18 336.8(35.6) 337.4(32.7) 356.3(29.9) 339.2(27.5) GROUP DOSE (mg/kg/day) N II-O 0 18 IV-0 50 18 VI-0 250 13 VIII-0 1000 18 LACTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 -2.0(12.3) 17.2(15.7) -15.2(10.0) -7.1(17.2) 17.6(13.5) -14.5( 9.1) 5.8(15.6) 11.6( 9.6) -11.6(12.5) 0.6(15.2) 18.9(14.7) -17.1(12.7) 0-21 0.0(17.9) -4.1(23.7) 7.5(18.4) 2.3(16.8) a Standard deviation is reported in parentheses. b N = 17. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). ;. ^: 359 : : :: empany Sanitized. Does not contain TSCA CB i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________ ,1 DuPont-4739 TABLE 46 (gramsMwEeiAgNhtDgaAinIL/gYraFmOsOfoDodCcOoNnsSuUmMedP)TBIOYNPj(gFrEamMsA) LAENRDAFTOSODDUERFIFNIGCIGEENSCTYATION GROUP DOSE (mg/kg/day) N GESTATION DAYS 0-7 7-14 0-14 II--0 0 16 IV-0 50 18 VI-0 250 133 VIII-0 1000 18 MEAN DAILY FOOD CONSUMPTION (grams) 24.9( 1.9 ) b 27.4 { 2.6) 26.2< 2.1) 25.0( 3.2) 26.9( 3.5) 26.0( 3.2) 23.8( 2.2) 25.9( 3.0) 24.9( 2.6) 23.3( 2.8) 25.0( 3.0) 24.1( 2.8) GROUP DOSE (mg/kg/day) N GESTATION DAYS II-O 0 16 IV-0 50 18 VI-0 250 13 VIII-0 1000 18 MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) 0-7 7-14 0.168(.045) 0.162(.038) 0.151(.037) 0.155(.025) 0.153(.035) 0.173(.026) 0.138(.040) 0.185(.024) 0-14 0.165(.026) 0.153(.020) 0.163{.023) 0.163(.019) a N = 17 for Days 7-14 and Days 0-14 intervals. b Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). ' . 360 Company Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 47 SUMMARY OF CLINICAL OBSERVATIONS IN Pi RATS Px MALE RATS GROUP DOSE (mg/kg/day) N OBSERVATIONS Alopecia Lung Noise Sore Tail Total No. of Rats with Masses Number of Rats with Given Sign 1-0 III-O V-0 VII-C 0 50 250 1000 20 20 20 20 6324 0100 1 01 0 0000 Px FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N OBSERVATIONS Alopecia Total N o . of Rats with Masses Number of Rats with Given Sign II-O IV-0 VI-0 VIII- 0 50 250 1000 18 18 13 18 2645 0000 Pi FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N Number of Rats with Given Sign II-O IV-0 VI-0 VIII- 0 50 250 1000 18 18 13 18 OBSERVATIONS Alopecia 2 64 6 Total No. of Rats with Masses 0001 Site: Mass lFOa (3.5 cm) Side(s) ' 0 0 0 1 Mass 2FO (2.0 cm) Side(s) 00 01 a FO = First Observed. There were no statistically significant trends by Cochran-Armitage test; p < 0.05. 361 Company Sanitized. Does not contain TS C A CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 48 MEAN ESTROUS CYCLE PPAiRFAEMMAETLEERRSAATNSD PRECOITAL INTERVAL Mean Dose Percent Percent Percent Mean Cycle Precoital (mg/kg/day) of Days in of Days in of Days in Length Interval Group N Estrus Diestrus Proestrus (days) (days) II-O 0 18 19(8.l)a 69(9.5) 12(7.6) 4.9(1.6) 2.8(1.6) IV-0 50 20 22(7.9) 67(9.5) 11(6.4) 4.8(0.7)i> 3.8(3.0) VI-0 250 20 22 (7.2) 63(8.8) 15(7.9) 4.5(0.9) 2.6 (2.3 )c VIII-0 1000 20 24(8.8) 64(10.8) 11(8.3) a Standard deviation is presented in parentheses. b N = 18 c N = 19 4.6(0.6)<* 2.7(1.7) There were no significant trends by Jonckheere-Terpstra test; p < 0.05. 362 CompanySanitized. Does notcons*n OBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 49 SUMMARY OF SPERM PARAMETERS IN Pi MALE RATS Group Dose (mg/kg/day) 1-0 0 III-O 50 MOTILITY Percent Motile S.D. 92.9 3.3(10)3 92.9 3.2(10) MORPHOLOGY Percent Normal S.D. 98.6 1.0(10) 98.1 1.1(10) EPIDIDYMAL SPERM (Millions) Per Cauda 313.9 S.D. 26.1(10) 324.4 30.5(10) Per gram Cauda S.D. 1109.8 179.7(10) 1182.8 136.4(10) TESTICULAR SPERMATIDS (Millions) Per Testis 150.2 S.D. 29.0(10) 152.5 18.5(10) Per gram Testis S.D. 93.8 10.9(10) 99.2 10.7(10) V-0 250 92.4 1.8(10) 97.9 1.4(10) 321.4 41.6(10) 1175.0 118.4(10) 155.9 36.5(10) 99.3 19.6(10) VII-0 1000 90.1 6.5(9) 97.7 1.4(9) 321.3 39.2(10) 1134.9 151.3(10) 150.5 25.4(10) 100.3 10.6(10) a Number in group is in parentheses. There were no significant trends by Jonkheere-Terpstra test; p < 0.05. 363 ''SCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 50 SUMMARY OF REPRODUCTIVE INDICES: Pi GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 50 VI-0 250 VIII-0 1000 MATING INDEX (%) (# copulated/cohoused) 100.0 100.0 95.0 100.0 (20/20) (20/20) (19/20) (20/20) FERTILITY INDEX (%) (# delivered/copulated) 90.0 90.0 68.4 90.0 (18/20) (18/20) (13/19) (18/20) GESTATION LENGTH (days) 21.9 21.9 22.0 21.9 Number of Implantation Sites per pregnant female 14.9 14.9 (3.47)a (2.19) 15.7 (1.87) 15.4 (2.04) Implantation Efficiency (%)> 91.2 91.2 87.1 (10.54) (12.51) (9.88) 93.8 (7.13) a Standard deviation for Number of Implantation Sites and Implantation Efficiency is reported in parentheses. b Number of pups born/number of implantation sites X 100. Determined for each litter. There were no statistically significant trends in mating or fecundity indices by Cochran-Armitage test; p < 0.05. There was no statistically significant difference from control in gestation length by One-Way Analysis of Variance; p < 0.05. There were no statistically significant trends in number of implantation sites or implantation efficiency by Jonckheere-Terpstra test; p < 0.05. 364 ftflPB Sanitized. Doesno!contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 51 MEAN PUP NUMBERS AND SURVIVAL: Ft GENERATION Bom Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 ' Day 21 MATERNAL GROUP DOSE (mg/kg/day) N II-O 0 18 IV-0 50 18 MEAN NUMBER OF PUPS/LITTER 13.9 13.7 13.4 7.9 7.9 7.9 7.9 13.8 13.8 13.5 7.8 7.8 7.8 7.8 MEAN NUMBER OF MALE PUPS/LITTER 6.6 6.6 6.5 3.9 3.9 3.9 3.9 6.4 6.4 6.2 3.8 3.8 3.8 3.8 MEAN NUMBER OF FEMALE PUPS/LITTER 7.3 7.4 7.1 7.4 6.9 7.3 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.0 VI-0 250 13 VIII-0 1000 18 13.5 13.4 13.2 8.0 7.4a 7.9 7 .9 a 14.8 14.6 14.5 7.9 7.9 7.9 7.9 7.2 7.2 7.2 4.0 3.7a 4.oa 4.0a 7.1 6.9 6.8 4.1 4.1 4.1 4.1 6.3 6.2 6.0 4.0 3.7a 3 .9 a 3.9a 7.7 7.7 7.7 3.8 3.8 3.8 3.8 Sex Ratio-k 0.48 0.45 Gestation Index0 Mean % Pups Born Alive 0-4 Day Viability Lactation Index^ 100.0 98.3 98.4 100.0 100.0 99.6 98.2 100.0 Litter Survival 100.0 100.0 a N = 12. b Number of male fetuses/total number of fetuses per litter, c Percent litters delivered having at least one live pup. d Mean percent survival from day 4 postculling to day 21. e Percent litters born with at least one pup-alive on day 21. 0.53 100.0 98.9 98.3 99.0 92.3 0.48 100.0 98.5 99.3 100.0 100.0 No statistically significant trend in sex ratio by linear contrast of least square means; p < 0.05. No statistically significant trend in mean numbers of pups, mean % born alive, 0-4 Day Viability, Lactation Index, or Litter Survival by Jonckheere-Terpstra test; p < 0.05. Statistics were performed on combined pups per litter only. Male and female data are presented for information only. 365 Does no!confali?TSCACBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 52 MEAN PUP WEIGHTS (GRAMS): Fj GENERATION MATERNAL GROUP DOSE (mg/kg/day) N II-O 0 18 Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.6 (0.6)* 11.2 (1.5) 11.3 (1-5) 18.0 (1.9) 37.6 (2.4) 60.0 (4.1) IV-0 50 18 VI-0 250 13 VIII-0 1000 18 MEAN PUP WEIGHTS 6.6 (0.5) 11.0 (1.4) 11.0 (1.4) 17.7 (2.0) 37.3 (2.9) 59.5 (5.1) 6.5 (0.6) 10.6 (1.7) 10.6 (1.8) 17.5 (1.9)c 37.1 (2.8)c 59.4 (4.2)^ 6.3 (0.4) 10.4 (1.0) 10.4 (1.1) 17.2 (1.5) 36.3 (2.5) 57.8 (3.9) MEAN MALE PUP WEIGHTS Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.8 (0.7) 11.5 (1.4) 11.5 (1.4) 18.3 (1.9) 38.1 (2.6) 61.5 (4.7) 6.8 (0.6) 11.4 (1.7) 11.4 (1.6) 18.2 (2.3) 38.2 (3.4) 61.4 (6.4) 6.7 (0.6) 10.9 (1.8) 10.8 (1.8) 17.8 (1.8)c 37.7 (2.6)c 61.0 (3.8)C 6.5 (0.5)d 10.6 (1.1) 10.7 (1.1) 17.5 (1.5) 37.0 (2.7) 59.4 (4.1) MEAN FEMALE PUP WEIGHTS Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.5 (0.6) 11.0 (1.6) 11.1 (1.6) 17.8 (1.9) 37.1 (2.4) 58.8 (3.9) 6.4 (0.5) 10.7 (1.3) 10.8 (1.4) 17.2 (2.0) 36.6 (3.0) 58.2 (5.1) 6.4 (0.6) 10.4 (1.7) 10.4 (1.7) 17.2 (1.9)c 36.5 (3.0)c 58.0 (4.4)c 6.1 (0.4) 10.2 (0.9) 10.2 (1-0) 16.8 (1.5) 35.6 (2.3) 56.1 (3.5) a Individual pup weights are presented in Appendix EE. b Standard deviation is reported in parenthe.ses. c N = 12. d One litter was excluded due to one pup being missexed. , There were no statistically significant trends by linear contrast of least square means; p < 0.05. Note: Statistical analyses were conducted on the combined pup weights. Male and female data are presented for information only. 366 RwspanySanitized. Does no!c'ww vcoa C! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 53 SUMMARY OF PUP CLINICAL OBSERVATIONS DURING LACTATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 50 VI-0 250 VIII1000 OBSERVATIONS Corneal Opacity Swollen Head 00 0 1(1) 0 Ul) 00 TOTAL NUMBER OF SIGNS NUMBER OF LITTERS AFFECTED TOTAL NUMBER OF LITTERS 0101 0 1 01 18 18 13 18 a Numbers outside the parentheses are the number of pups affected; the numbers in parentheses are the number of litters affected. There were no statistically significant trends by Cochran-Armitage test; p < 0.05. 367 PompanySanitized. Deenot H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 54 MEAN BODY WEIGHTS O(gFraFmtsM) AANLDE MRAETASN BODY WEIGHT GAINS GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 43 1-1 III-l V-l 0 50 250 18 18 12 60.8( 4.8)* 104.2( 6.2) 168.5(.9.2) 229.4(18.5) 295.3(21.1) 358.1(25.9) 410.0(32.5) MEAN BODY WEIGHT (grams) 59.8( 6.5) 105.3( 9.8) 171.3(13.5) 232.8(20.1) 299.8(22.2) 362.2(25.5) 419.5(30.8) 61.7( 4.4) 103.8( 7.4) 167.8(11.2) 226.8(16.8) 291.8(25.1) 350.1(35.6) 396.3 (40.3) VII-1 1000 18 58.5( 5.0) 100.8(10.2) 162.8(14.8) 224.3 (19.7) 287.5(24.0) 347.8(28.7) 399.2 (32.2) GROUP DOSE (mg/kg/day) N 1-1 0 18 III-l 50 18 V-l VII-1 250 1000 12 18 DAYS ON TEST3 MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 15-22 22-29 29-36 36-43 43.5{ 4.0) 64.3( 5.2) 60.9(12.4) 65.9(10.8) 62.8( 7.1) 52.0( 9.8) 45.5( 5.2) 66.0( 5.1) 61.6(11.7) 67.0(12.7) 62.4(10.2) 57.3( 7.5) 42.1( 4.3) 63.9( 5.0) 59.0( 8.1) 65.0(14.2) 58.4(12.8) 46.1(10.0) 42.2( 6.1) 62.1( 5.6) 61.4( 8.1) 63.2 (10.1) 60.4( 8.2) 51.4( 5.3) 1-43 349.3(31.1) 359.7(28.1) 334.5(37.6) 340.6(29.1) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). 368 Does notcontain 'w a H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 55 MEAN BODY WEIGHTSOAFNFDi FMEMEAANLEBORADTYSWEIGHT GAINS (grams) GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1 8 15 22 29 36 43 II-l 0 18 IV-1 50 18 VI-1 250 12 MEAN BODY WEIGHT (grams) 59.1( 4.5)> 98.3( 4.8) 144.5( 7.4) 182.2( 9.9) 206.6(11.5) 229.2(13.1) 247.8(16.5) 56.6( 5.5) 95.2( 6.4) 143.8(10.7) 177.8(13.0) 204.1(17.4) 227.3(21.9) 248.8(25.1) 57.2( 6.5) 96.0( 9.8) 144.8(13.2) 182.4(18.0) 206.1(19.9) 229.0(25.4) 251.2(33.4) VIII-1 1000 18 55.2( 3.8) 92.5( 6.0) 139.6( 8.8) 174.7( 9.2) 197.9(12.7) 224.1(16.7) 240.1(17.2) GROUP DOSE (mg/kg/day) N II- 1 0 18 IV-1 50 18 VI-1 250 12 VIII-1 1000 18 DAYS ON TEST MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 15-22 22-29 29-36 36-43 39.2( 4.3) 46.2 ( 4.7) 37.7( 6.8) 24.4 ( 5.3) 22.7( 5.4) 18.6 ( 8.2) 38.7( 4.2) 48.5( 5.7) 34.0( 7.6) 26.3( 8.0) 23.2( 7.3) 21.5( 7.0) 38.7( 4.8) 48.8( 4.7) 37.7( 6.1) 23.6( 8.8) 22.9( 7.5) 22.3( 9.1) 37.3( 3.8) 47.0( 4.9) 35.2( 5.5) 23.2( 5.8) 26.2( 8.0) 15.9( 5.7) 1-43 188.7(14.4) 192.3 (24.4) 194.0(29.7) 184.8(16.4) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). 369 Company Sanitized. Does not contain TSC A CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 56 MEAN DA(IgLrYamFsOwOeDighCtOgNaiSn/UgrMamPTsIfOooNd(cgornamsusm) eAdN) DBYMFEiAMNAFLOEORDAETFSFICIENCY GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 36-43 1-43 I-1 III--1 V- 1 VII -1 0 50 250 1000 18 18 12 18 MEAN DAILY FOOD CONSUMPTION (grams) 13.9 ( 0.9)i> 21.3 ( 1.3) 25.1( 2.2) 29.9( 2.1) 31.8( 1.8) 32.7( 3.1) 25.8( 1.4) 14.0( 1.5) 21.8( 1.8) 26.0( 2.4) 30.7 ( 2.9) 32.1( 3.0) 34.0( 3.4) 26.4( 2.1) 14.2 ( 1.7) 21.3( 2.1) 25.3 ( 2.1) 29.8 ( 2.8) 31.5( 3.5) 31.4( 3.2) 25.6( 2.2) 13.3 ( 1.3) 20.6( 1.9) 25.2( 2.5) 29.4( 3.2) 31.4( 3.1) 31.6( 4.8) 25.2( 2.3) GROUP (m gD/kOgS/Eday) N DAYS ON TEST 1-8 8-15 15-22 22-29 29-36 36-43 1-43 1-1 0 III-l 50 V-l 250 VII-1 1000 18 18 12 18 (grams MEAN FOOD EFFICIENCY weight gain/grams food consumed) 0.448(.031) 0.432(.031) 0.345(.049) 0 . 3 1 5 ( .042) 0.282(.026) 0.226(.029) 0.463(.026)) 0 .4 3 4 ( .029) 0.338(.053) 0 . 3 1 0 ( .033) 0.277(.031) 0 . 2 4 1 ( .018) 0 . 4 2 8 ( .051) 0.433(.045) 0.333 (.039) 0 . 3 1 0 ( .045) 0.263(.033) 0.209 (.040) 0,452(.038) 0.43K .028) 0 . 3 4 8 ( .033) 0.307(.031) 0 . 2 7 5 ( .029) 0 . 2 3 9 ( .057) 0.322(.017) 0.324(.011) 0.311(.021) 0.322(.016) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). 370 Company Sanitized. Does not contain TS C A 6 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 57 MEAN D(AgrILamYsFwOeOigDhtCgOaiNn/SgUraMmsPTfoIoOdNco(gnrsauimnse)dA) NBDY MFIEFAENMFAOLOEDREAFTFSICIENCY GROUP DOSE (mg/kg/day) N DAYS ON TEST3 1-8 8-15 15-22 22-29 29-36 36-43 1-43 II- 1 0 18 IV- 1 50 18 VI- 1 250 12 VIII -1 1000 18 MEAN DAILY FOOD CONSUMPTION (grams) 13.4 ( 2.2)& 18.7 ( 1.1) 20.3( 1.7) 21.6( 1.5) 21.3( 1.9) 21.9( 2.3) 19.5( 1.2) 12.7 ( 0.9) 18.7 ( 1.6) 19.3( 4.4) 20.8( 2.0) 21.6( 2.2) 22.4( 2.7) 19.2( 1.7) 13.0( 0.9) 18.7 ( 1-4) 21.0( 1.4) 21.3( 1.9) 21.7( 3.2) 22.6( 3.3) 19.7 ( 1.8) 12.7 ( 0.9) 18.0( 1.1) 19.9 ( 1.7) 20.0( 3.2) 21.6( 2.3) 21.1( 2.4) 18.9 ( 1.5) GROUP DOSE (mg/kg/day) N II-l 0 18 IV-1 50 18 VI-1 250 12 VIII-1 1000 18 DAYS ON TEST3 MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) 1-8 8-15 15-22 22-29 29-36 36-43 0.429{.086) 0.353 (.036)) 0.265(.044) 0.161(.029) 0.15K .028) 0.12K .052) 0.437(.044) 0.37M .027) 0.310(.307) 0.178(.046) 0.152(.040) 0.136(.038) 0.425(.038) 0.372(.032) 0.256(.029) 0.157(.058) 0.148(.033) 0.137(.045) 0.420 (.030) 0.373( .026) 0.252 (.035) 0.169(.054) 0.172(.047) 0.108(.037) 1-43 0.230{.012) 0.238(.019) 0.233{.022) 0.233(.011) a Day of Weaning = Test Day 1. Jb Standard deviation is reported in parentheses. There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05). 371 Sanitized.Company Does not contain TSC A C1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 58 SUMMARY OF CLINICAL OBSERVATIONS IN F l RATS Fx MALE RATS OBSERVATIONS Corneal Opacity GROUP DOSE (mg/kg/day) N Number of Rats with Given Sign 1-1 III-l V-l VII-1 0 50 250 1000 18 18 12 18 Masses 0001 00 00 Fx FEMALE RATS GROUP DOSE (mg/kg/day) N Number of Rats with Given Sign II-l IV-1 VI-1 VIII- 0 50 250 1000 18 18 12 18 OBSERVATIONS There were no abnormal clinical signs observed in the Fl Female Rats. Total No. of Rats with Masses____________ 0 0 0 0 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. 372 Com pany Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 59 SUMMARY OF DEVELOPMENTAL LANDMARKS IN F, RATS PREPUTIAL SEPARATION - Fj. MALE RATS GROUP DOSE (mg/kg/day) N H 1 0 18 III-l V-l VII-1 50 250 1000 18 l i a 18 (Days) b 48.8 1.9 48.8 2.7 48.9 3.4 48.8 1.9 VAGINAL OPENING - Fx FEMALE RATS GROUP DOSE (mg/kg/day) N II-l 0 18 IV-1 50 18 VI-1 250 12 VIII1000 18 AGE (Days)b 32.3 3.2 34.6 3.6 34.5 3.7 32.9 2.6 Data summarized as: Mean Standard Deviation a One animal in this group (n=12) had incomplete preputial separation. b Test day preputial separation or vaginal patency was complete (Appendix LL) +20 days (Day of Weaning = Test Day 1) There were no statistically significant trends by JonckheereTerpstra test; p < 0.05. 373 CompanySanitized. Dees notconfa'ntsca J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TABLE 60 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Pi ADULTS Group 1-0 0 mg/kg/day Group III-O Group V-0 Group VII-0 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day THYROID 0.023 0.006(20 ) 0.024 0.005(20 ) 0.022 0.003(20 ) 0.024 0.006(19 ) FINAL BODY 602.387 592.060 594.387 537.547# 79.955(15 ) 41.996(15 ) 55.508(15 ) 61.934(15 ) THYROID/FINAL BODY * 100 0.004 0.001(15 ) 0.004 0.001(15 ) Data summarized as : Mean Standard Deviation (n) fstatistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 0.004 0.001(15 ) 0.005 0.001(14 ) DuPont-4739 ^Company Sanftfzed. Does no!confafnTSCAcbj 374 >:-W V', ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________ TABLE 61 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Pj ADULTS Group II-0 0 mg/kg/day Group IV-0 Group VI-0 Group VIII-0 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day THYROID 0.018 0.006(19 ) 0.020 0.005(20 ) 0.019 0.005(19 ) 0.017 0.005(20 ) FINAL BODY 347.616 351.930 352.084 339.920 22.976(19 ) 27.966(20 ) 27.217(19 ) 27.685(20 ) THYROID/FINAL BODY * 100 0.005 0.002(19 ) 0.006 0.002(20 ) Data summarized as : Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 0.006 0.001(18 ) 0.005 0.002(20 ) DuPont-4739 Does notcontain TSCACBI 375 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 62 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - l ADULTS MEAN FINAL BODY AND ABSOLUTS ORGAN WEIGHTS (grams) Group 1-1 0 mg/kg/day Group III-l Group V-l Group VII-1 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day BRAIN EPIDIDYMIDES 1.944 0.092(18 ) 0.838 0.090(17 ) 1.992 0.046(18 ) 0.816 0.064(18 ) 1.957 0.135(12 ) 0.816 0.110(12 ) 1.945 0.069(18 ) 0.797 0.084(18 ) TESTES SEMINAL VESICLES 3.216 0.181(18 ) 1.266 0.208(18 ) 3.220 0.182(18 ) 1.211 0.125(18 ) 3.289 0.298(12 ) 1.176 0.355(12 ) 3.230 0.262(18 ) 1.233 0.232(18 ) PROSTATE 0.480 0.118(18 ) 0.510 0.112(18 ) 0.442 0.117(12 ) 0.494 0.079(18 ) THYROID LIVER FINAL BODY 0.024 0.004(18 > 18.588 2.117(18 ) 410.044 32.544(18 ) 0.023 0.005(18 ) 18.910 1.909(18 ) 419.539 30.808(18 ) 0.018# 0.002(12 ) 17.638 2.933(12 ) 396.267 40.274(12 ) 0.017# 0.004(18 ) 17.538 1.846(18 ) 399.172 32.215(18 ) MEAN RELATIVE ORGAN WEIGHTS ( % ; of body weight) Group 1-1 0 mg/kg/day Group III-l Group V-l Group VII-1 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day SEMINAL VESICLES/FINAL BODY * 100 0.311 0.058(18 ) 0.289 . 0.292 0.029(18 ) 0.072(12 ) 0.309 0.053(18 ) PROSTATE/FINAL BODY * 100 0.117 0.029(18 ) 0.122 0.028(18 ) 0.111 0.029(12 ) 0.124 0.019(18 ) THYROID/FINAL BODY * 100 0.006 0.001(18 ) 0.005 0.001(18 ) 0.005# 0.000(12 ) 0.004# 0.001(18 ) LIVER/FINAL BODY * 100 4.530 0.299(18 ) 4.508 0.324(18 ) 4.429 0.415(12 ) 4.394 0.333(18 ) 376 figm pany Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 62 (CONTINUED) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fj ADULTS MEAN RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) Group 1-1 Group III-1 Group V-l Group VII-1 0 mg/kg/day 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day EPIDIDYMIDES/BRAIN * 100 43.092 4.880(17 ) 40.980 3.106(18 ) 41.625 4.514(12 ) 41.005 4.152(18 ) TESTES/BRAIN * 100 165.640 9.696(18 ) 161.745 10.539(18 ) 167.892 6.878(12 ) 166.283 14.473(18 ) SEMINAL VESICLES/BRAIN * 100 65.199 10.721(18 ) 60.796 6.240(18 ) 59.705 17.228(12 ) 63.447 12.062(18 ) PROSTATE/BRAIN * 100 24.737 6.146(18 ) 25.601 5.600(18 ) 22.671 6.578(12 ) 25.415 4.149(18 ) THYROID/BRAIN * 100 1.226 0.193(18 ) LIVER/BRAIN * 100 957.214 107.680(18 ) 1.140 0.267(18 ) 0.913# 0.128(12 ) 949.177 898.080 94.524(18 ) 116.996(12 ) 0.862# 0.183(18 ) 901.506 87.354(18 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 377 J& iqpany Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 63 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fj ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) Group II-l 0 mg/kg/day Group IV-1 Group VI-1 Group VIII-1 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day BRAIN 1.805 0.054(18 ) 1.836 0.068(18 ) 1.810 0.145(11 ) 1.783 0.071(18 ) UTERUS 0.473 0.149(18 ) 0.561 0.184(18 ) 0.512 0.125(12 ) 0.433 0.100(18 ) THYROID 0.019 0.003(18 ) 0.019 0.003(18 ) 0.016# 0.004(12 ) 0.011# 0.003(17 ) LIVER 10.263 1.384(18 ) 10.586 1.378(18 ) 10.412 2.058(12 ) 9.953 1.230(18 ) FINAL BODY 247.844 248.817 251.233 240.067 16.469(18 ) 25.141(18 ) 33.378(12 ) 17.203(18 ) MEAN RELATIVE ORGAN WEIGHTS (% of body weight) Group II-1 0 mg/kg/day Group IV-1 Group VI-1 Group VIII-1 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day BRAIN/FINAL BODY * 100 0.732 0.056(18 ) 0.744 0.070(18 ) 0.728 0.078(11 ) 0.747 0.066(18 ) UTERUS/FINAL BODY * 100 0.192 0.062(18 ) 0.227 0.073(18 ) 0.207 0.055(12 ) 0.182 0.050(18 ) THYROID/FINAL BODY * 100 0.008 0.001(18 ) 0.008 0.002(18 ) 0.006# 0.002(12 ) 0.004# 0.001(17 ) LIVER/FINAL BODY * 100 4.132 0.394(18 ) 4.255 0.338(18 ) 4.117 0.368(12 ) 4.140 0.350(18 ) 378 JRappansfSanRbed. Does nofe**r*w'anpH H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 63 (CONTINUED) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) Group II-1 0 mg/kg/day Group IV-1 Group VI-1 Group VIII-1 50 mg/kg/day 250 mg/kg/day 1000 mg/kg/day UTERUS/BRAIN * 100 26.161 7.794(18 ) 30.535 9.999(18 ) 28.099 7.050(11 ) 24.296 5.596(18 ) THYROID/BRAIN * 100 1.078 0.162(18 ) 1.011 0.186(18 ) 0.881# 0.186(11 ) 0.601# 0.166(17 ) LIVER/BRAIN * 100 569.033 __________________ 77.812(18 ) 576.000 67.159(18 ) 576.128 103.469(11 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 557.992 63.193(18 ) 379 oirpany Sanitized. Does no! contain r s c a c m H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TABLE 64 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - P! ADULTS DuPont-4739 SITE/LESION: LUNGS DISCOLORATION EPIDIDYMIDES DISCOLORATION TESTES SOFT SKIN ALOPECIA GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: 1-0 0 20 0 0 0 0 III-O 50 20 0 0 0 1 NOTE: O INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. V-0 250 20 0 0 0 0 VII-0 1000 20 1 1 1 0 Does notcontain TSCACBS 380 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 65 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS -P i ADULTS SITE/LESION: URINARY BLADDER DILATATION KIDNEYS CALCULUS VAGINA FLUID DISCOLORATION SKIN ALOPECIA GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: II-O 0 20 0 0 0 0 0 IV-0 50 20 0 0 0 1 1 NOTE: O INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. VI-0 250 20 1 1 1 0 0 VIII 1000 20 0 0 0 0 0 381 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 MALE PUPS SITE/LESION: TABLE 66 INCIDENCES OF GROSS OBSERVATIONS IN RATS - Fj PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 1/1 IV-0 50 0/0 VI-0 250 0/0 VIII-0 1000 4/3 STOMACH NO MILK SPOT LUNGS NOT EXPANDED WHOLE BODY AUTOLYSIS 1 ( 1) 1 ( 1) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 3 ( 3) 3 ( 3) 1 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 1003 1 004 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________ DuPont-4739 FEMALE PUPS SITE/LESION: STOMACH NO MILK SPOT PERITONEAL CAVITY FLUID LUNGS NOT EXPANDED - TABLE 66 (Continued) INCIDENCES OF GROSS OBSERVATIONS IN RATS - Fj PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 4/3 IV-0 50 1/1 VI-0 250 3/2 VIII-0 1000 0/0 s = ss 5=ss ss ss 4 ( 3) 1 ( 1) 2 ( 2) 0 ( 0) 0 ( 0) 0 ( 0) 1 ( 1) 0 ( 0) 4 ( 3) 1 ( 1) 2 ( 2) 0 ( 0) ODijjanySanfflzetf. Does TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 312 0 413 0 1 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. I Numbers in parentheses are the number of litters affected. 383 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 66 (Continued) INCIDENCES OF GROSS OBSERVATIONS IN RATS - Fi PUPS UNSEXABLE PUPS SITE/LESION: TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: := = = = = = = = = = = = = = = = = = = = = = = II-O 0 0/0 0 0 II II II II II !! II II II II II II II II II II II II II II II II II II II II II It II II IV-0 50 0/0 0 0 VI-0 VIII-0 250 1000 0/0 0/0 = = == == == = =s== = : 00 00 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TABLE 67 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi WEANLINGS DuPont-4739 SITE/LESION: GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: THERE WERE NO GROSS OBSERVATIONS 1-1 0 52 III-l 50 49 V-l 250 35 VII1000 54 Does nocontain TSCACBII 385 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TABLE 68 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi WEANLINGS DuPont-4739 SITE/LESION: LUNGS DEFORMITY KIDNEYS DILATATION GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: II-l 0 53 0 1 IV-1 50 54 0 0 NOTE: o INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. VI-1 250 35 1 0 VIII-1 1000 51 0 0 .CompanySanfttzecf. Does no!contafn TSCACB! 386 H90--2D46a1y6G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations TABLE 69 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi ADULTS DuPont-4739 SITE/LESION: KIDNEYS DILATATION GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: 1-1 0 18 2 III-l 50 18 1 NOTE: O INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. V-l 250 12 2 VII1000 18 3 CompanySanitized. Does notcontain TSCACBI 387 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 70 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fj ADULTS SITE/LESION: LIVER MASS KIDNEYS DILATATION BRAIN SOFT GROUP DESIGNATION: DOSE (mg/kg/day): NUMBER IN GROUP: II-l 0 18 0 2 0 IV-1 50 18 1 2 0 NOTE: o INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. VI-1 250 12 0 2 1 VIII 1000 18 0 1 0 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________ DuPont-4739 II IIIIII IIIIlllIII tOo tOn hHH1 IIIIIIIIIIII o II II IIII ir ii innt n ii IIIIIIIlIIIIIIit Oto OOOp HOH1< II II II II IIII TABLE 71 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS - Pi ADULTS GROUP DESIGNATION: 1-0 LESION GRADES DOSE (mg/kg/day): 0 TISSUE/LESION (P,1,2,3,4) NUMBER IN GROUP: 20 = s s = = a s E 2 s s s s s s s s s i : s : s s s s s s : s s s s s s s s s s s = s = : = s s s ; s s s s 5 s = = = ==========:====: TESTIS8 2 DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES TESTES 0 EPIDIDYMIS8 GRANULOMA, SPERM OLIGOSPERMIA/GERM CELL DEBRIS EPIDIDYMIDES 2 - 0 PROSTATE INFLAMMATION, SUBACUTE/CHRONIC SEMINAL VESICLES 2 2 COAGULATING GLAND 2 2 1 2 - 1 3 3 3 V-0 250 20 3 4 3 - 4 7 1 (-,1, 7 7 l l (-,-,-,-,1) 2 1 1 (-,-,1,-,-) 1 (-,-,-,-,1) 2 3 3 3 Does notcontain TSCACBl 389 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 71 (CONTINUED) INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS - P, ADULTS OTHER 0101 LUNGS: FOREIGN MATERIAL LUNGS: INFLAMMATION, GRANULOMATOUS SKIN: INFLAMMATION/LCER 1 (-,1, 1 (-,1, 1 (-,1, NOTES : o THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. o LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". a One of the pair available for microscopic examination. Sperm parameter evaluation was performed on the second of the pair. M f i 390 HH>H OOOH O03 II|IIII|II oHH1 O ( NO HIIIIIIIIII PiwspanySanitized. Does notcontain TSCAcm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ 1 DuPont-4739 TABLE 72 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS - Pj ADULTS GROUP DESIGNATION: LESION GRADES DOSE (mg/kg/day): TISSUE/LESION (P,1,2,3,4) NUMBER IN GROUP: = = s==: = s=sr5= = =: = s:5 s= := := = sss:ss sz = := ;= :ss 5 s s:s :s:= := :r:ss ss :s5 s:s : = =:=:=; = s = :s ;s s s :s := := s = = = = = OVARIES 2 ATROPHY - UTERUS 2 IV-0 50 20 2 2 VI-0 250 20 8 1 (-,-,1,-,-) 8 2 2 VAGINA 2282 OTHER 0010 HYDRONEPHROSIS, BILATERAL KIDNEYS: INFLAMMATION, ACUTE URINARY BLADDER: INFLAMMATION, SUBACUTE/CHRONIC - 1 (-,-,1,-,-) 1 (-,-,-,-,1) 1 (-,-,1,-,-) - NOTES: o THE NUMBER OP ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. o LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". 391 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 TABLE 73 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE RATS - Fj ADULTS LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG): NUMBER IN GROUP: ==5====:=:= 1 -1 V II -l 0 1000 18 18 : s = = = = = = ss =: s: ss ss s = = s = = ss ssss; + THYROID GLAND ALTERATION, COLLOID 18 18 _ 1 (- NOTES : o THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. O LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ DuPont-4739 TABLE 74 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE RATS - Fi ADULTS LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG): NUMBER IN GROUP: II-l 0 18 VIII-1 1000 18 ==s:s==sr=: sssssssss + THYROID GLAND 18 18 NOTES : O THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. O LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED'. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". CompanySanitized. Does notcontain T8CACil 393 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 FIGURES 394 ^empaiqfSanitized. Doesnotcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations FIGURES EXPLANATORY NOTES DuPont-4739 Critical Date Day 69 and 90 Day 91 Body weights at these time points were collected prior to sacrifice or removal from study and are not included in the figures. Recovery period begins for rats designated for the one-month and 3-month recovery periods. 395 ompwySanitized.DoesnotcontainTSCAC9 'J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________________________ DuPont-4739 FIGURE 1 MEAN BODY WEIGHTS OF MALE RATS i Days on Test 396 Doesnolcontain T8CAfiSl J H90--2D46a1y6G: aSvuabgcehSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations FIGURE 2 MEAN BODY WEIGHTS OF FEMALE RATS DuPont-4739 Does no!contain TSCAC8 Days on Test 397 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 3 MEAN FORELIMB GRIP STRENGTH (kg) OF MALE RATS DuPont-4739 Company Sanitized. Doesnot contain TSCACBI Omg/kg/day 0 5 0 mg/kg/day B 250 mg/kg/day M 1000 mg/kg/day Baseline Week 12 Error bars represent standard deviation. Assessment Period 398 Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________________________ DuPont-4739 FIGURE 4 MEAN FORELIMB GRIP STRENGTH (kg) OF FEMALE RATS 1.60 -r 1.40 1.20 - Omg/kg/day B 50 mg/kg/day El250 mg/kg/day B 1000 mg/kg/day 0S not contain TSCACB Baseline Week 12 E_rror bars represent stand..a..r.d....d..e..v..i.a..t.ion. Assessment Period 399 Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________________________________________ DuPont-4739 FIGURE 5 MEAN HINDLIMB GRIP STRENGTH (kg) OF MALE RATS Sanitized. Does notcontain TSCAOB'S 0 mg/kg/day 1150 mg/kg/day E250 mg/kg/day M1000 mg/kg/day Baseline Week 12 ,,Error bars represent stand.a..r..d...d...e..v..i.a..t.ion. Assessment Period 400 Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 6 MEAN HINDLIMB GRIP STRENGTH (kg) OF FEMALE RATS DuPont-4739 Hindlimb Grip Strength (kg) 0 mg/kg/day II50 mg/kg/day 13250 mg/kg/day M 1000 mg/kg/day Baseline Error bars represent standard deviation. Week 12 Assessment Period Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Jljifl H DuPont-4739 FIGURE 7 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR MALE RATS 2500 2000 - 1500 C0 1000 - 1 Q 500 - 0mg/kg/day 50 mg/kg/day II250 mg/kg/day 1000 mg/kg/day Does notcontain tc/*a Baseline Week 12 Error bars represent standard deviation. Assessment Period 402 Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 FIGURE 8 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR FEMALE RATS 2500 2000 - 1500 -I 0mg/kg/day H50mg/kg/day 250 mg/kg/day M 1000 mg/kg/day Duration of Movements (sec) Baseline Week 12 Error bars represent standard deviation. Assessment Period Recovery -J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ DuPont-4739 FIGURE 9 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR MALE RATS M^anjSanftfzedLDoes notcontain TSCAC1 Error bars represent standard deviation. Assessment Period 404 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ( DuPont-4739 FIGURE 10 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR FEMALE RATS jBsppaf SanRlzed. Does noi confata TSCA cm 3 I o > Omg/kg/day o II50 mg/kg/day 1n(D ^ 250 mg/kg/day U 1000 mg/kg/day Baseline Week 12 Error bars represent standard deviation. Assessment Period 405 Recovery H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDICES 406 gSm paty SanRfeed. Doesno!contain f 6 A81 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX A INDIVIDUAL DOSE VOLUMES 407 ntconfato TSCACtf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Critical Dates INDIVIDUAL DOSE VOLUMES EXPLANATORY NOTES Day 69 Male and female rats designated for reproduction evaluations were co-housed. Dose volumes administered during the cohabitation and post-mating periods are doscumented in study records. Day 90 Last day of test substance administration for male rats designated for the 90-day exposure and one-month and 3-month recovery periods, and female rats designated for one-month and 3-month recovery periods. Day 91 Last day of test substance administration for female rats designated for the 90-day exposure period. 408 W P? SanRfeed. Does no!coniai H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 0 Male, I - 0 mg/kg/day 641149 641155 641222 641214 641069 641070 641147 641172 641206 641094 641098 641066 641115 641220 641104 641114 641217 641204 641158 641100 641060 641188 641106 641175 641079 641125 641186 641052 641140 641135 641174 641107 641072 641053 641168 641084 641154 641085 641105 641215 641123 641101 641165 641083 641159 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 Day 1 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 2 Day 3 Day 4 Day 5 Day 6 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 0.98 1.00 1.00 1.00 1.00 1.10 1.00 1.00 1.10 1.10 0.94 0.98 1.10 0.95 1.10 1.20 1.10 0.91 1.00 0.95 1.10 0.98 1.10 0.97 0.99 1.10 1.00 1.10 1.20 1.00 1.10 0.98 1.00 1.10 1.00 0.99 1.00 1.00 1.20 1.00 0.97 1.20 0.99 1.10 1.00 Day 7 1.20 1.20 1.30 1.30 1.30 1.30 1.20 1.20 1.40 1.30 1.10 1.10 1.30 1.10 1.30 1.50 1.30 1.10 1.30 1.10 1.40 1.20 1.30 1.20 1.20 1.40 1.30 1.30 1.50 1.20 1.30 1.20 1.30 1.30 1.20 1.20 1.30 1.20 1.40 1.20 1.20 1.40 1.20 1.20 1.20 DuPont-4739 Day 8 1.20 1.20 1.30 1.30 1.30 1.30 1.20 1.20 1.40 1.30 1.10 1.10 1.30 1.10 1.30 1.50 1.30 1.10 1.30 1.10 1.40 1.20 1.30 1.20 1.20 1.40 1.30 1.30 1.50 1.20 1.30 1.20 1.30 1.30 1.20 1.20 1.30 1.20 1.40 1.20 1.20 1.40 1.20 1.20 1.20 Does no!contain TSC& 409 .-y ..... H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________ _______________ DuPont-4739 CompanySanitized. Doesnotcontain TSCCBI Day 9 Day 10 Male, I - 0 mg/kg/day 641149 1.20 1.20 641155 1.20 1.20 641222 1.30 1.30 641214 1.30 1.30 641069 1.30 1.30 641070 1.30 1.30 641147 1.20 1.20 641172 1.20 1.20 641206 1.40 1.40 641094 1.30 1.30 641098 1.10 1.10 641066 1.10 1.10 641115 1.30 1.30 641220 1.10 1.10 641104 1.30 1.30 641114 1.50 1.50 641217 1.30 1.30 641204 1.10 1.10 641158 1.30 1.30 641100 1.10 1.10 641060 1.40 1.40 641188 1.20 1.20 641106 1.30 1.30 641175 1.20 1.20 641079 1.20 1.20 641125 1.40 1.40 64.11.86 . _ ,, l.,3Q. _ _ _ 1-310 641052 1.30 1.30 641140 1.50 1.50 641135 1.20 1.20 641174 1.30 1.30 641107 1.20 1.20 641072 1.30 1.30 641053 1.30 1.30 641168 1.20 1.20 641084 1.20 1.20 641154 1.30 1.30 641085 1.20 1.20 641105 1.40 1.40 641215 1.20 1.20 641123 1.20 1.20 641101 1.40 1.40 641165 1.20 1.20 641083 1.20 1.20 641159 1.20 1.20 _ INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 11 Day 12 Day 13 1.20 1.20 1.30 1.30 1.30 1.30 1.20 1.20 1.40 1.30 1.10 1.10 1.30 1.10 1.30 1.50 1.30 1.10 1.30 1.10 1.40 1.20 1.30 1.20 1.20 1.40 1.30 1.30 1.50 1.20 1.30 1.20 1.30 1.30 1.20 1.20 1.30 1.20 1.40 1.20 1.20 1.40 1.20 1.20 1.20 1.20 1.20 1.30 1.30 1.30 1.30 1.20 1.20 1.40 1.30 1.10 1.10 1.30 1.10 1.30 1.50 1.30 1.10 1.30 1.10 1.40 1.20 1.30 1.20 1.20 1.40 1.30 1.30 1.50 1.20 1.30 1.20 1.30 1.30 1.20 1.20 1.30 1.20 1.40 1.20 1.20 1.40 1.20 1.20 1.20 1.20 1.20 1.30 1.30 1.30 1.30 1.20 1.20 1.40 1.30 1.10 1.10 1.30 1.10 1.30 1.50 1.30 1.10 1.30 1.10 1.40 1.20 1.30 1.20 1.20 1.40 1.30 1.30 1.50 1.20 1.30 1.20 1.30 1.30 1.20 1.20 1.30 1.20 1.40 1.20 1.20 1.40 1.20 1.20 1.20 410 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 14 Male, I - 0 mg/kg/day 666644441111122X52145249 641069 641070 641147 641172 666644441111200009966486 666644441111121120110445 641217 641204 641158 641100 641060 641188 666666644444441111111101101107728546595620 '666444111111073745 641072 664411015638 664411018544 666644441111011282015355 666644441111011180653159 1111111111111111111...................33566544653367524340000000000000000000 111111 ......364543 000000 11111111111 ........... 64574444453 00000000000 111111111 ......... 456446454 000000000 Day 15 11111 ..... 33565 00000 1.60 1.40 - 41111111........4563364200000000 1.70 1.50 1.30 1.40 1.30 1.60 1111 .... 4543 0000 111111......456744000000 1.40 1.40 1.50 1.40 1.30 1.50 1.40 111 ...644 000 1111.... 6454 0000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 16 Day 17 Day 18 Day 19 Day 20 1.30 111 ... 355 000 11.. 66 00 1.40 111111111.........645336247000000000 - 1.50 1.30 1.40 111111 ...... 364543 000000 11 .. 64 00 1.50 111 ... 744 000 1.40 1.40 11.. 54 00 11111111 ........ 35464644 00000000 1.50 1.40 1111 .... 3355 0000 1.60 1.60 1.40 11111.....6533400000- 11111111111111111.................6247533464543645700000000000000000 11 ..44 00 11 ..44 00 1.50 1.40 1.30 1.50 111111 ...... 464464 000000 1.50 1.40 11111111 ........ 33556644 00000000 111111111111111111111111111...........................653362475343645436457444454000000000000000000000000000 111111...... 354644 000000 1111 .... 6454 0000 1.30 111... 355 000 11.. 66 00 1.40 ..... l-11111111i4........5336247600000000 . - 1.50 111 ... 343 000 11111..... 64543 00000 11 .. 64 00 1111.... 5744 0000 1.40 1.40 11 .. 54 00 1.30 1.50 1.40 1111.... 6446 0000 11 .. 45 00 1.40 11.. 33 00 111 ... 556 000 1.60 1.40 * -11..4600 111 ... 533 000 1.60 111 ... 427 000 111 ...534 000 1.30 1.60 1111 ....4543 0000 1.60 11 .. 45 00 11111 ..... 74444 00000 11 .. 54 00 1.30 1.50 1.40 111 ... 464 000 1.60 111 ... 454 000 DuPont-4739 Day 21 Day 22 1.50 1111111-.......56787560000000 11111111........7744969400000000 11111111111111111 ................. 75649565696695665 00000000000000000 1111 .... 5567 0000 1.80 1.70 - - 1111111.......65774490000000 111 ...694000. 1.70 1.50 1.60 1.40 11111 ..... 95656 00000 1.90 1.60 11 .. 69 00 111 ...566 000 1.50 11 ..76 00 11 ..76 00 1111111111 .......... 5668567666 0000000000 11 ..56 00 11111111........68567666 00000000 Does notcontain TSCACBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 23 Male, I - 0 mg/kg/day 666666444444111111110220457216950249 641147 666666666664444444444411111111111120001211229670912011046268504474 666666666444444444111111111111101101280770568566590808 641052 666666666666666664444444444444444411111111111111111010111111100101215682370785801405635335472445550198 11 ..55 00 11 ..67 00 1.80 1111111 ....... 7567744 0000000 1.90 111... 469 000 1.70 1.50 1.60 1.40 111... 956 000 11.. 65 00 1.90 1.60 11.. 69 00 1111....65560000 11.. 76 00 1111.... 5668 0000 1.50 1111 .... 6676 0000 1.60 Day 24 111111111111111111..................755675867744945697000000000000000000 111 ... 964 000 1111 .... 6565 0000 11111111111111111111 .................... 66966555668576667669 00000000000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 25 Day 26 Day 27 Day 28 11111111 ........ 55678756 00000000 1111111111111 ............. 7744496975649 0000000000000 1111 .... 5566 0000 11 .. 69 00 11111111 ........ 69566576 00000000 1111111111 .......... 5766666586 0000000000 11111111 ........ 55856776 00000000 1111111111111111111 ................... 7744946979669656455 0000000000000000000 11111111 ........ 69566567 00000000 1111111111 .......... 6666566857 0000000000 11111 ..... 55678 00000 1.70 111111111111 ............ 567744946795 000000000000 111111111111111111111111111 ........................... 649566596696576576566856666 000000000000000000000000000 111121111111211221111111121...........................660989788855057117888678617000000000000000000000000000 121111111111111111 .................. 717777979868797887 000000000000000000 412 Day 29 11112 ..... 66890 00000 1111112221111111 ................ 9788850115857876 0000000000000000 111121 ...... 778861 000000 121111111111111111 .................. 717778768797897798 000000000000000000 DuPont-4739 Day 30 1111211 ....... 6689097 0000000 111... 888 000 112112121111111 ............... 550571716886788 000000000000000 21 .. 17 00 12111111 ........ 71777798 00000000 1111111111 .......... 7878797896 0000000000 Day 31 1111 ....6689 0000 21 ..09 00 1.70 1.80 1.80 111... 855 000 2.00 1.50 12 ..71 00 1.80 1.70 1.80 21 .. 16 00 211111......188677000000 ' 1.70 2.10 11 ..77 00 11 ..77 00 11 .. 98 00 111111111 ......... 868778979 000000000 1.70 Seesnotcontain TSCACI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________ Day 32 Male, I - 0 mg/kg/day 666666444444111111012201752164052499 666666666666444444444444111111111111210112201012076011491209426447785064 666666666666666666666666666444444444444444444444444444111111111111111111111111111101121001010110111101110111685210585805467283777006805539351344552089565425760808 1112111.......90976860000000 1.80 1111211....... 8855057 0000000 211 ...187 000 121111 ...... 617888 000000 1.60 11212 ..... 77171 00000 111 ...777000 ' 11.. 98 00 11 .. 86 00 111111......797897000000 1.80 1.70 Day 33 2211111111111111112111121.........................18867867188557850689097860000000000000000000000000 21.. 17 00 111111111112111111..................787897978689777177000000000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 34 Day 35 Day 36 Day 37 11111111121211111211111112111111211211111.........................................7978898677771717886786187571855086909786800000000000000000000000000000000000000000 1111 .... 7879 0000 2111211111121122211111111.........................19877729896692799601097790000000000000000000000000 12111211211221112111....................8089891900887288882900000000000000000000 2121111111211221111112111112............................98721798979829626910799679070000000000000000000000000000 11121122121211111.................9889018008982878800000000000000000 111112112121111211121111121112211.................................887898272798719899299662619790077000000000000000000000000000000000 21 .. 08 00 211211121.........908198809000000000 1.80 Day 38 1211112111121112221111111.........................79877198926962901079996770000000000000000000000000 21 .. 29 00 2111 .... 8288 0000 11 .. 87 00 21.. 08 00 2112111121..........80981898090000000000 413 DuPont-4739 Day 39 2111211211111221111...................29899626919967790070000000000000000000 2111121121121111................08878298287717980000000000000000 1211212111..........89089091880000000000 Day 40 111211112221111...............966269979010797000000000000000 21111121112111121.................2888872981797982900000000000000000 211 ... 087 000 211212111.........089991808000000000 1.80 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 41 Male, I - 0 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111110011200012201212101110110121110110101101211456747099612172520106078543108707285685850106959072648652495304700656205448472338844595515 122112111111212211111111........................710679079996262179989798000000000000000000000000 121121111 ......... 287298887 000000000 222111121111 ............ 008088918989 000000000000 Day 42 211222 ...... 088121 000000 1.80 22211211222221112121121122221221112221......................................0017737940400888083994890900000898001900000000000000000000000000000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 43 Day 44 Day 45 Day 46 222112......102881000000 112222......880121000000 1.80 22211211221 ........... 00177379408 00000000000 1.80 2.00 2211 ....0177 0000 211 ...379 000 . 221...408000 21..0800 21..0800 21221.....8004800000 22121.....4080800000 21121121222221122121....................3994890800000980190900000000000000000000 21121122212111222122....................3994890009089809000100000000000000000000 1122 .... 8801 0000 22222111211221212122121211121212221221221.........................................2100187737980848340008949890000809019009800000000000000000000000000000000000000000 112222 ...... 880121 000000 1.80 2.00 222211112121............130777948080000000000000 . 2122 .... 4800 0000 12211 ..... 83499 00000 211121 ...... 089809 000000 122212212 ......... 800190090 000000000 2.00 Day 47 112222 ...... 882011 000000 22121121221211..............0081773948080700000000000000 2122221112112122221221211.........................04803089948908000190090980000000000000000000000000 DuPont-4739 Day 48 11222222121121122222212111112112................................8801200181773794004008388849989000000000000000000000000000000000 2221212221211.............00098090019080000000000000 Day 49 11222..... 89023 00000 2212211212221212122122222222112121222222 ........................................ 1181187480521859008300109520999009112011 0000000000000000000000000000000000000000 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 50 Male, I - 0 mg/kg/day 666666666666666666666666666666666666666666664464444444444444444444444444444444444444444441141111-111111111111111111111111111111111111110111121110101100111110101112000122011021220118512610058385467708277068055096112901707216453943551545543082476255900868486570444062249759 2211....02980000 2.30 2.10 1.80 2.10 12221122........7408851100000000 12221.....8519200000 221...009000 1.80 2222....50030000 2222222221221121................10100121109920990000000000000000 . Day 51 2211....02980000 2.30 221212221111222212..................059819524878011181000000000000000000 2.00 1.80 22222121121222..............2112099590900300000000000000 222222......011010000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 52 Day 53 Day 54 Day 55 2121....29080000 2.30 21212121222112122221....................0890589120588741118100000000000000000000 22222222221221121222....................0011102110920959900300000000000000000000 22211.....3029800000 2212212121212.............95208741811810000000000000 22222221212211222221121.......................1021109209059903080598100000000000000000000000 222...101000 2.00 2211....20980000 22222222122211122222221212121222122111222.........................01..0.11.0..21......91..20..9909050380059189205481187181300000000000000000000000000000000000000000 22211.....3028900000 2.10 1.80 2.10 22..1100 ' 2122121221121.............90581925084780000000000000 21 .. 80 00 22 .. 03 00 22211122........0209990500000000 1.90 2.10 2222....12010000 22 .. 01 00 2.10 2.00 Day 56 222221222112122211..................206186228823933189000000000000000000 21 .. 92 00 2221....12690000 222212222221............012190061149000000000000 222222222.........132111322000000000 Day 57 1222211.......93331890000000 22222222222221222222221121222222122211........................13.12.11....322..0...21...1900614121996962021826228800000000000000000000000000000000000000 DuPont-4739 Day 58 22211.....3319800000 222222222221222222222211212222212122221.1......................1..13.21....31.2210....29....01.06114912969620218926322880000000000000000000000000000000000000000 Does notcontain TSCACBS ssam H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 59 Male, I - 0 mg/kg/day 666666666666666664444444444444444411111111111111111112200112000121124251674709916201192549072648560447 666666666666666644444444444444441111111111111111211011101101101100568077285707430480865956247205 666644441111001155863448 666666664444444411111111100111212880051633551955 1122 .... 8913 0000 22.. 33 00 122211212 ......... 922288681 000000000 2.60 22212212122222221.................2029629194116190000000000000000000 222222222222 ............ 210223111213 000000000000 Day 60 1122 .... 8913 0000 2.30 2.30 1.90 222 ... 222 000 11 ..8800 212 ...681 000 2.60 2.20 2.00 2.20 1212 .... 9692 0000 21 .. 19 00 2222222122 ..........11600192140000000000' 22 ..02 00 222222 ...... 231121 000000 2.30 2.10 INDIVIDUAL DOSE VOLUMES (inL) FOR MALE RATS Day 61 Day 62 Day 63 Day 64 11222 ..... 89133 00000 2.30 1.90 2.20 221 ... 228 000 1.80 212 ... 681 000 2222 .... 6202 0000 12.. 96 00 . 21122.....2991400000 2.10 2222 ....1600 0000 2.10 1.90 2.20 2.10 22.. 02 00 222222......231211 000000 2.30 2.10 1122 .... 8913 0000 22 ..33 00 1222112122..........92228868160000000000 222122122122222212..................202969211941601920000000000000000000 2.10 22 ..02 00 22222222 ........ 23311121 00000000 1222 .... 9023 0000 22 .. 43 00 1.90 222112122.........313875816000000000 22222222122...........3030702196100000000000 222222222222222222 .................. 160100311223421324 000000000000000000 122222 ...... 902343 000000 122211212222............931387581630000000000000 22222222122...........3070216191600000000000 22.. 00 00 22.. 10 00 22 .. 31 00 2.10 222222222......... 234213242 000000000 416 Day 65 122222 ...... 902343 000000 122212112222222222..................931385781630307021000000000000000000 221222222 ......... 619160010 000000000 22222222222 ........... 31123342124 00000000000 2.20 DuPont-4739 Day 66 1.90 2222 .... 0234 0000 21222 ..... 39313 00000 112122 ...... 875816 000000 222222221222............303070219611000000000000 22.. 60 00 222 ... 010 000 22222222222 ........... 31123423421 00000000000 2.20 Day 67 1.90 2.00 22.. 3200 2.40 2.30 1.90 2.30 22.. 3100 1121 .... 8758 0000 22.. 6100 2.30 22 .. 03 00 22 .. 07 00 2.00 2.20 21.. 9100 2.60 2.10 22.. 6100 2.00 2.00 2.10 22.. 3000 2.10 2.10 222 ...234 000 2.20 22.. 3100 22.. 4200 2.20 Dees notcontainTSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 68 Male, I - 0 mg/kg/day 641149 666444111122521524 664411007609 641147 641172 666666666644444444441111111111020011212291009621104546860474 641158 t \ 666666 66 444444111111101101 441111 707068569008 2856 664411015420 664411113754 641107 641072 664411015638 666666666444444444111111111011001211828801065334555154 641159 122222122211 ............ 902343931387 000000000000 21 ..58 00 22222222221 ........... 07213091630 00000000000 22 .. 61 00 2222222222222222 ................ 2214130011360312 0000000000000000 2.40 2.20 Day 69 222122122211 ............ 023934931387 000000000000 21 ..58 00 2222222222222222212222222222222...............................42322142107163030961160010311230000000000000000000000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 70 Day 71 Day 72 Day 73 22222222 ........ 00345404 00000000 221211 ...... 549698 000000 2.20 222222......005434 000000 2.00 22221112 ........ 45469892 00000000 222222 ...... 003445 000000 2.00 22211212 ........ 45498692 00000000 222222...... 003454 000000 2.00 2.40 2 2 ..4500 . 1.90 1.80 212 ... 692 000 2222222222 .......... 2232445323 0000000000 222222222 ......... 452322343 000000000 2.20 222222222 ......... 233244523 000000000 2.20 222222222 ......... 523243432 000000000 2.20 417 Day 74 2222 .... 0034 0000 22222..... 54045 00000 211212 ...... 498692 000000 2222222222 .......... 4523324223 0000000000 DuPont-4739 Day 75 2222 ....0034 0000 22 ..54 00 222211212 ......... 504498692 000000000 Day 76 2222 ....0034 0000 22 ..54 00 222211 ......045498 000000 212 ...692 000 2.20 22222222........2434523300000000 . 2.20 2222222222 .......... 4223452332 0000000000 ! i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 77 Male, I - 0 mg/kg/day 666666444444111111002211762145092495 664411114772 666644441111020060996648 666644441111111211204504 666666666444444444111111111101112102070870561690854807 666666664444444411111111011110117703542824752056 666666666666444444444444111111111111101110121010580625801568931534555384 222222 ...... 556114 000000 212221221.........279559491000000000 2222222222..........63343345420000000000 Day 78 222222 ...... 655141 000000 212211222.........792959451000000000 222222222.........633445324000000000 2.30 INDIVIDUAL DOSE VOLUMES (mL) Day 79 Day 80 Day 81 MALE RATS Day 82 222112122222222...............299795514556411000000000000000 22222222 ........ 41156514 00000000 22.. 55 00 21211 ..... 29799 00000 222222 ...... 651451 000000 22 .. 41 00 2121221 ....... 2979559 0000000 22 .. 11 00 2222 .... 6554 0000 2.10 2.40 1212221.......92975950000000 ' 222222222.........363454324000000000 2.30 2222222222..........33643445320000000000 2222222222..........36334345420000000000 2.20 222222222.........343653344000000000 Day 83 2222222222..........45551645110000000000 11 ..99 00 21.. 79 00 2.20 2222222222..........63433453240000000000 DuPont-4739 Day 84 222222 ...... 756031 000000 22 .. 51 00 2212221 ....... 0389659 0000000 Day 85 2.10 22 .. 30 00 2.60 22 .. 57 00 222 ...156 000 2211....89950000 22 .. 03 00 2222222222..........54533346350000000000 2.30 222222222.........455333465000000000 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 86 Male, I - 0 mg/kg/day 666644441111112221452495 666666666664444444444411111111111001120001216774069912090276648504 666666666666666666666666444444444444444444444444111111111111111111111111111221101011001110011101110075068728574375856080474658008956220543448755 666666444444111111102111280651331595 2222 .... 1036 0000 22222211222...........7515659980300000000000 2222 .... 3546 0000 222222 ...... 335345 000000 Day 87 22222 ..... 10367 00000 2.50 222211222 ......... 156599803 000000000 2222 ....3546 0000 222222 ...... 333545 000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 88 Day 89 Day 90 2222 ....1036 0000 2.70 2222212122..........55615989030000000000 222222222211222 ............... 103675156599803 000000000000000 2222 .... 2136 0000 22 ..75 00 222211222 ......... 157699803 000000000 2222222222.......... 3546335354 0000000000 2222222222 ..........3546335354 0000000000 2.30 222222222 ......... 546335354 000000000 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 0 Day 1 Male, III - 50 mg/kg/day 666644441111021074513668 641178 666666666664444444444411111111111210120111001295628549834490575481 666664444411111111019029198818 666666666666664444444444444411111111111111111011111011129727086715623013143121163989 0000000.......00000005555555 0.05 00000000000000000.................0000000000000000055555565556555565 000... 000 556 0000000.......00000005555565 0000 .... 0000 5555 0000 .... 0000 5555 00000000000 ........... 00000000000 55556556555 000000 ...... 000000 555556 0000000000..........00000000005555555566 Day 2 INDIVIDUAL DOSE VOLUMES mL FOR MALE RATS Day 3 Day 4 Day 5 Day 6 00000000 ........ 00000000 55555555 0000000.......00000005565555 00000000000000000000....................0000000000000000000055555556655555556565 000000000000000000..................000000000000000000555655555555655555 0000000 ....... 0000000 5555556 00000000........0000000055555665 00 .. 00 55 0000 .... 0000 5555 00 .. 00 55 00 .. 00 55 0000000000..........00000000005565555655 0000000000000.............00000000000005655555565565 00 .. 00 55 00.. 00 55 00000000000000 .............. 00000000000000 55555555655555 00.. 00 56 0.05 000000000000000000..................000000000000000000555555655565555565 0000000000000000................00000000000000006555565555555555 00000.....0000056555 00 .. 00 55 00 .. 00 55 000000000.........000000000555566555 0.05 Day 7 0000000000000000................00000000000000005667667666666666 00000000........0000000066657666 00000000000...........0000000000076667667676 DuPont-4739 Day 8 00000000000000..............0000000000000066666666676566 00.. 00 67 000 ... 000 666 0000000000000000................00000000000000007666676776666657 H90--2D46a1y6G: aSvuabgcehSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Day 9 Day 10 Male, III - 50 mg/kg/day 666666666666666666666666666666666444444444444444444444444444444444111111111111111111111111111111111102011010210112110111101111101211475197548295162076802012993871652636888541449305333799888198111261 664411017941 000000000000000...............000000000000000666666666576666 00.. 00 76 0.06 000000000000000 ............... 000000000000000 675666676776666 00.. 00 76 00 ..00 66 0000000000000000000...................00000000000000000006666666765666766657 000000000000............000000000000766667676666 00 .. 00 76 Day 11 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 12 Day 13 00 .. 00 66 0.06 0.06 0.06 0.06 00 .. 00 66 0000 .... 0000 6765 00 .. 00 66 00.. 00 67 00.. 00 66 0.06 0.05 0.07 0000....00006666 0.07 00 .. 00 76 0000 .... 0000 6676 0.06 0.07 0.06 000000 ...... 000000 666666 000000000.........000000000666576666 0000000000000000000...................00000000000000000007667776657666666766 0.06 0000 .... 0000 6666 00000000000000000000000000000.............................0000000000000000000000000000066666765666766657666767766666 00 ..00 76 421 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 14 Day 15 Male, III - 50 mg/kg/day 666644441111102047516368 666666666666666664444444444444444411111111111111111011102101102111015479821956820129954881434907588819 666644441111121160233998 666666664444444411111111111110110758716233611121 664411017941 0000000000000000000...................00000000000000000006777777778667787877 00000000 ........ 00000000 68777778 000000 ...... 000000 887777 00 ..00 87 000000000000000...............000000000000000677777777866778 00000000000000000000....................0000000000000000000087776877778787778787 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 16 Day 17 Day 18 Day 19 Day 20 000000000000000...............000000000000000767777777686787 00 .. 00 78 00.. 00 77 0000000000..........00000000006877787878 000000 ...... 000000 777787 0000000000000000000...................00000000000000000006777777778667878777 000000 ......000000 687777 0000000 ....... 0000000 7888777 000 ... 000 778 000000 ...... 000000 677777 000000000000000000000000000...........................000000000000000000000000000777866778787768777778877778 00.. 00 87 0000000 ....... 0000000 6777777 000000000.........000000000677867878 000 ... 000 777 0000000000000000................00000000000000006777887788777778 0000 .... 0000 6777 000000000000000000000.....................000000000000000000000777778667878777678777 00.. 00 87 00.. 00 88 00 .. 00 77 0000 .... 0000 7787 Day 21 000000 ...... 000000 778788 0.08 00000000000...........0000000000097976798987 000000 ...... 000000 879778 000000000 ......... 000100000 988088888 00 .. 00 89 DuPont-4739 Day 22 0000000000..........00000000007787887899 0000000000000000000000000.........................00000000000000000100000007679898787977988808889888 Sanitized. Does notcontainTSCACB! 422 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________ Day 23 Day 24 Male, III - 50 mg/kg/day 666644441111001275413668 641178 641055 666666666666666666666444444444444444444444111111111111111111111111112111010110212011062389092915498262801339819948139481405788 664411117111 666644441111101176523261 664411017941 000000 ...... 000000 878778 0.08 0.09 00000000 ........ 00000000 96797798 00 .. 00 78 00000000 ........ 00000000 79887978 000000000.........000001000889880888 - 000000000.........000000000778897788 0000 .... 0000 6977 0000000000000000000000......................00000010000000000000008988980888788978778899 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 25 Day 26 Day 27 Day 28 Day 29 000000 ...... 000000 878778 00 .. 00 98 00000000 ........ 00000000 68979977 0000000000000000000...................00000000000100000008988888789808797788 000000 ...... 000000 877887 00.. 00 89 000000 ...... 000000 697977 000000000000000000000.....................000000000001000000000988780988888789787898 0000 .... 0000 7887 00000000 ........ 00000000 97678978 0000000000000000000000......................00000000100000000000009988808887878978779898 0.08 0000000.......00000008998888 000000000000............001000010100908709988088 0000000000000000................01000011000000009099980808888988 0000 .... 0000 8988 00000000000...........0100100001070980888908 0000000000..........00000000008988898889 0000000000..........00101010009809080989 Day 30 00000000 ........ 00001000 98890888 0000000 ....... 1001000 0870988 00000000000000000000....................1000000110000000000009999800888898898988 DuPont-4739 Day 31 000000 ...... 000000 988888 000000 ...... 001010 780890 00000000000000000000000.......................0010101000000000000100099080099888888989880998 Does notcontain TSCAopt* 423  >J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 32 Day 33 Male, III - 50 mg/kg/day 641146 666644441111020175173688 666666666666666666666666666666444444444444444444444444444444111111111111111111111111111111110102121110101101211101111011162054829792716525680199023879335354144388112619078819998141 0.08 00000 ..... 00000 89888 00000000000000000 ................. 00101000100000000 99080870998898888 00 ..00 88 000000000 .........101000001 080999808 0.09 0.08 00000 ..... 00000 89888 0000000000000 ............. 0101001000000 9080870998898 0000000000000000 ................ 0000011001000000 9888800990988898 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 34 Day 35 Day 36 Day 37 Day 38 0000 .... 0000 8898 0.08 000 ... 001 890 0000000000 .......... 1000000100 0879888098 0.09 0000000000000000................00010000101000000989888808099898 00000 ..... 01000 80899 0.09 0000000000000.............11001000100010098187909991 00.. 00 89 00000000000000..............0010101001100199090999109900 0000.... 0010 8809 00.. 00 99 0.10 00000 ..... 10100 08187 0000 .... 0011 1990 00000 ..... 00000 99989 00 ..00 99 000000000000 ............ 101010001011 090909991900 00 ..00 88 0000 .... 1000 0999 0000000000 .......... 1101010100 0081819079 00 .. 00 99 00000 ..... 00000 98999 000000000000 ............ 100010110110 099909109009 000000000000000000..................001000110110000010088099908119799809 0.09 000000...... 000000 899999 0000000000 .......... 1010011011 0909910900 Day 39 000000000000000000000000000000000.................................001000111000010100000001001000111099889001988719099899990909999100 00 .. 10 09 DuPont-4739 Day 40 00000000000000000000....................0000101101000011000099880900817899109998 0000....0000 9999 00000000000 ........... 01001001111 90999091000 I.Desnotcontata TSCAC9f 424 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________ DuPont-4739 Day 41 Day 42 Male, III - 50 mg/kg/day 666664444411111010127574136868 641055 666666666666666666444444444444444444111111111111111111111212001201011111264212899089596012934435719914980888 666666666664444444444411111111111110111110117279087165331413111268 000000000000000000000000........................000001000101000000100101999980999171999980908088 00000000000...........1000110101109990091900 0000 .... 0010 9909 0.09 0.09 0.10 0000000 ....... 1101000 1191989 000000000000000000000.....................111111111000101010110100000020999190909009 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 43 Day 44 Day 45 Day 46 Day 47 0000 .... 0010 9909 000000000000000000000.....................000011001100011010010999900990099901919918 00000000 ........ 11111111 20000010 00 ..11 10 00000000000000000000000000000.............................1110001001000100111001100101001299909909990991009900991918 00..1100 0000 .... 1111 0100 00000000000000000000000000000000000...................................1111111111000010001001000110100011100010001029999099909909990191989100 00000..... 00100 99099 0000000000000000000000000000............................11111111010101000110010100010002010090090909099991919891 0.11 0.10 00000 ..... 00001 99990 0.09 000000000000000000 .................. 100111010010000110 110909909909989109 0000000000..........11111111100001001029 0.10 Day 48 0000 .... 0001 9990 00 .. 00 99 000000000000 ............ 001100010111 990099191180 000000 ...... 001010 990909 0000000000..........11111111101000209100 0.10 Day 49 0000000000000000 ................ 0000101000111111 9999191989211000 000000000 ......... 110011010 009901909 000000000 ......... 111111111 010010211 0.10 fiwipany Sanitized. Doesnotcontain TSCAcurt 425 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 Day 50 Day 51 Male, III - 50 mg/kg/day 6666666666666666644444444444444444.11111111111111111110210120100112101754829562809417533541449057886886 666666666666444444444444111111111111111111101211716208399012113931819988 666666444444111111110101726795312416 00000 .....00110 99009 0.09 0000000000 .......... 1011001011 1911192890 000 ... 101 190 00000000 ........ 11110010 00119909 0000 .... 1111 1200 0000 .... 1111 1000 0000000000000000000000000000000000..................................11111111101101011011000110011010011001112009000991190189900990191992 0.10 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 52 Day 53 Day 54 Day 55 Day 56 0000000000000000000000000000000000..................................11111111111001000010101110011100110101200100199099991291811099019900 0.10 00000..... 00110 99009 00000000000000000000....................0111010011101000110190009199019198921190 000000......111111200111 0000 .... 1111 0100 00000 .....00110 99090 0000000000000000000000......................11101101101100001011101109009119019999290118 00000000 ........ 11111111 00101200 0.09 000 ... 101 090 0.09 0.09 00.. 11 01 00 .. 01 91 00 .. 00 89 0000 .... 0111 2911 00 ..01 90 0.11 0.09 000... 100 099 0.10 0.10 00 .. 11 11 0.12 0.10 000...111001 ' 00.. 11 01 0.10 000000 ...... 110011 009910 00 .. 11 21 00000000 ........ 11111001 02102991 0000000000000000................11111111111101010110212000019190 000 ... 111 111 Day 57 00000 ..... 11001 00991 0.10 0000000000000000000000......................11111111011001111011112200011019299021190201 00.. 11 00 00000 ..... 11111 11111 Day 58 0000000000000000................11110011111111002102990121000199 00000000 ........ 11101101 00091190 00.. 11 02 000000000.........111111111112011110 S ? * " * Sanitized. Does notcontain TSC n* 426 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________ Day 59 Day 60 Male, III - 50 mg/kg/day 666666666644444444441111111111110200110249827545714814356688 666666644444441111111101201112805693578904 641118 666666666664444444444411111111111111111120111870623092911133989189 666666444444111111111010727965314126 0.09 00000 ..... 10111 09100 0.11 0.12 0.10 0.12 0000 .... 1001 2990 00.. 11 11 0.09 0.10 0.11 0.09 0.11 0000 .... 1111 0000 00.. 11 21 0.12 0.10 000000 ......111111111101 . 00000000000000000000000000..........................1111110111011101111011101002001090119921012029010909 00o...11i20T 0000 .... 1111 1110 00.. 11 11 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 61 Day 62 Day 63 Day 64 Day 65 000000 ...... 111010 000919 0000 .... 1111 2210 0000000.......01110109211909 0000 .... 0111 1910 00 .. 11 00 00000.....1111121200 0000000.......11111111111100 000000 ...... 100111 099100 0000000.......01101119029201 000 ... 111 121 00000 ..... 10101 19190 000 ...111 000 00.. 11 02 0.11 000 ... 111 200 00000 ..... 11111 11111 0000000000000000000000000000000...............................11111111111101111100111111111000012211000119110129902021100199 0000 .... 1111 2110 00000000........1111101012010919 00.. 11 02 000000000000000000000000........................111111111111111101111001201101202010011192110990 0.11 000000 ...... 101110 911009 00000000000...........1111001111110219900212 000000000000000000..................111111111111111011211102010120091011 Day 66 000000000000000000..................111111011011110011110102920290119910 00000000000000000.................1111111111111111021201101120001019 '-- DuPont-4739 Day 000000 ...... 111100 110099 0000 .... 1111 2021 0000000000000000000000000.........................11111111111111101111110012110012120010019112110990 / ja u U SA U|B|U0 0 p u saoQ "p i|ii g 427 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 Day 68 Male, III - 50 mg/kg/day 666666666666666644444444444444441111111111111111011010110212001271564575498292813390668548144578 666666644444441111111111110269012903988819 666666666666444444444444111111111111110111101111708162792375331121419816 00.. 00 99 0000 .... 1111 1001 0.11 0.12 0.10 00.. 10 29 0.09 00 .. 11 20 00.. 11 11 00 .. 11 01 0.11 0000 ....0111 1090 00 ..11 01 0000 .... 1111 0212 000 ... 111 011 0.10 0.12 0.11 Day 0000 .... 0101 9191 0.10 000000 ...... 111101 201209 000000000000 ............ 111011011111 001910902111 000000000000 ............ 111111111111 021110212001 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 70 Day 71 Day 72 Day 73 Day 74 00000 ..... 11111 10011 000 ... 111 230 00000000 ........ 11111111 30011102 000 ... 111 001 00000 ..... 11111 30112 000... 111 001 0000 .... 1111 1201 0.13 000... 111 001 000 ... 111 101 0.12 0.13 0000000.......11111013030091 0000000.......11110113300901 0000000.......11110113300901 0000000.......11111103301009 0000000.......11111103301009 Day 75 00000..... 11111 00111 0.10 0.12 0.13 0000000 ....... 1111011 3300901 Day 76 0000000 ....... 1111111 1110002 00000000 ........ 11101111 33309010 jS ii V O S i UjBJUOO JOU S0 OQ -j 428 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 77 Day 78 Male, III - 50 mg/kg/day 641146 641218 666644441111010077553865 641144 641198 666444111021829144 666666644444441111111101211018021653785809 641128 641091 666444111211906993 664411112398 641103 641181 I 666666664444444411111111101111107757291634611112 00000 ..... 11111 21100 0000000000..........11111111103323000209 00000000 ........ 11111111 32120010 0000000.......11111103320009 INDIVIDUAL DOSE VOLUMES (mL) Day 79 Day 80 Day 81 00000 ..... 11111 12100 0.10 0.12 00000000........1111111033203090 000000 ...... 111111 201100 00 .. 11 32 000...111300 0000....11013290 0000 .... 1111 2100 00000.....1111130021 000000......111101332090 `Pdzjuues^wdusog aoD 0 1 s 429 g Ol FOR MALE RATS Day 82 Day 83 000000......111111100102 000000......111111001102 000000000.........111110111332009032 00 .. 11 32 0000000 ....... 1111101 3320090 Day 84 000000......111111002110 00.. 11 24 0000000.......11111102300409 DuPont-4739 Day 85 000000000000000...............111111111110111304200211009240 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 86 Day 87 Male, III - 50 xng/kg/day 666666666666444444444444111111111111012110210001755414982957365684814498 664411111630 666666666666666666644444444444444444441111111111111111111111111011120121110176028902716582012933335799111261988818 664411109714 0000 .... 1111 0201 000 ... 111 201 00000000........1111011134009042 0000 .... 1111 0021 00 .. 11 01 000000000 ......... 111101111 320090424 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 88 Day 89 Day 90 00000000........ 11111111 00211024 00000000 ........ 11111111 11000224 0000 .... 1111 2002 0000 .... 1111 1124 0000000.......11110113200904 0000000.......11101113009042 0000000.......11111013021094 C m ^ m 9 Sanitized, Does notcontain o 430 0 1 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 0 Male, V - 250 mg/kg/day 666666666666664444444444444411111111111111101011010111220748839930096626197700420712 666666666666666666664444444444444444444411111111111111111111111111010111101011117852842918712625374792124205905745681680 641164 0000000000000000000...................22222222222222222223395855765764584566 00.. 22 47 0000000000000.............22222222222229674858646774 0.26 Day 1 0000 .... 2222 5756 00.. 22 57 0000000000 .......... 2222222222 3986454568 0000000000000000000...................22222222222222222229654876467786347465 Day 2 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 3 Day 4 Day 5 Day 6 0000000000000000................22222222222222223689454586576557 00 .. 22 36 00000000000000000.................2222222222222222249656784646778475 0000 .... 2222 5576 000 ... 222 576 0000000.......22222223658454 000000000000000000000.....................222222222222222222222749664657678483547896 0000 ....2222 5576 000 ... 222 576 0.24 000000000000000000000000000...........................222222222222222222222222222974865767646834457396854568 0.25 0000000000000000000000......................22222222222222222222226374543985645845665767 00.. 22 46 00 .. 22 57 00000000........2222222269674878 000 ... 222 557 000 ... 222 576 0000 .... 2222 5864 0000000000000000000000000.........................22222222222222222222222229866747578464635473456896 Day 7 00000000 ........ 33332232 33119919 00 .. 33 32 000000 ...... 333223 323781 0000000000000000000...................33323333333333323233457021321124223709 DuPont-4739 Day 8 00000000........3332233233119919 00 .. 33 32 000000......333223332781 000 ... 323 370 0000 .... 3233 2921 0000000000..........33233333334327421012 00 .. 33 35 ay 9 Day 10 Male, V - 250 mg/kg/day INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 11 Day 12 Day 13 666666666666666666666666666444444444444444444444444444111111111111111111111111111011101110011111010100122111821787135762484097386600939247506918056178206791202740 666666664444444411111111111111116742825949204215 0.31 0.29 .00000.....23333 131 93 0.29 0.32 0.33 000 ... 232 817 0.32 00 .. 33 33 00 .. 23 37 00 .. 23 90 0.32 0.31 000 ... 333 212 0.34 0.30 0.33 0.32 00000.....3332354172 0.33 00 .. 23 91 00 .. 33 13 0.31 00 .. 23 93 0.29 0.32 0000000.......33332233321378 00 .. 23 37 000 ... 323 290 0000....33332121 000...333340 . 0.32 0000 .... 3233 4721 0.35 0.33 00000000........2323332393913191 00000000........3333223333812372 0000000000..........33333323234212219037 000000000.........333233333354721230 000000000.........322333323299311391 00000.....3322321387 0000000000000.............33333332323330421221907333 000000......323333473212 00..3335 00 .. 23 91 0000000.......32233332939131 000000000000000000..................333333323323333223401221290337312783 00000000........3332333334571223 I ISOvosi U|Buooiou H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 Day 14 Day 15 Male, V - 250 mg/kg/day 666666444444111111112120930906042701 i 666666666666666666666666666644444444444444444444444444441111111111111111111111111111111111100111111010101011011145928278781298624715368307472152409250740756169812972680 641164 000000000.........333333333365674477 00000000000000000000000000..........................3334433333333333333333333366200878584691276698244868 00000000000000000000000000000000000...................................3334433333333333333333333333333333366200894785689248632166846564478777 INDIVIDUAL DOSE VOLUMES (inL) FOR MALE RATS Day 16 Day 17 Day 18 Day 19 Day 20 00000 ..... 33333 37566 00000 ..... 33333 63576 0000....33333567 0.36 00000 ..... 33333 36756 00000 ..... 33333 36756 0.37 0000 ....3333 4478 000000000000000...............333333333333333665828448126769 0000000000..........33443333336200869478 0.37 0000 .... 3333 4847 00 .. 33 21 00 ..33 67 00 .. 33 96 0000000000000000000...................33443333333333333336200864785944866828 0.37 0000 .... 3333 4478 00.. 33 12 00.. 33 67 00 .. 33 96 000 ... 333 248 000000 ...... 333333 548668 000 ... 333 479 00000 ..... 34333 20866 0.40 0.38 0.37 00 .. 33 44 000000000000000000000000000...........................343343333333333333333333333608205786486689241276984786 000...333447 000000000000000000000000000...........................333443333333333333333333333284660058782466926984867781 Day 21 00000000 ........ 33434444 72620710 000000000000000...............443434344334443219271602541218 000000000000............334444434344329656270348 Day 22 00000000000000000000000.......................3444443344334444433434341211169227282201077056 00 .. 43 38 0000000000..........44434344342563672094 Bes notcontain TSCA 433 - H-24616: Subchronic Toxicity J 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 23 Day 24 Male, V - 250 mg/kg/day 664411119304 664411210927 664411020601 666666666666666666666666666664444444444444444444444444444411111111111111111111111111111111111101111110010100111111102846768178285920837465371472924249279504215029761581678060 0.42 000 ... 434 260 0000 .... 4433 1077 000000000000000000000000000...........................444443433434344434444334433356230729762840251211692418 0000000 ....... 4344344 2217600 0.37 000000000 ......... 433444444 051211421 000000000000000000..................444433444434433333632096523422778896 Day 25 INDIVIDUAL DOSE VOLUMES Day 26 Day 27 00000 ..... 44443 12206 000 ... 343 707 0000000.......44344342260170 0.37 0000000 ....... 4443344 2217600 0.37 0000000000000000000...................43433344444333344443747522801168941212 0000000000 .......... 4344444433 0512121146 000000000.........444333334342778892 00 ..44 02 00000000000000000.................4334433443334444337822784915412116 00 .. 44 23 000000 ...... 443344 609652 00000000 ........ 43444344 39622506 00000000 ........ 44444334 23620965 434 2 (itlL) FOR MALE RATS Day 28 Day 29 000000000000000000000000000...........................444444444443444334444344434370180052950157446646484495 00000000........4443444493559186 000000000000000000000000000000000.................................444344444444444434434344443444344381970563180052664689501574444954 00 .. 44 59 Day 30 00000000000000000000000000000.............................4444444444434443444344334444437065512800646485074649951544 00 .. 44 31 00..34 98 00.. 44 95 DuPont-4739 Day 31 0.44 000000000.........444344443545016959 0000000000000000000...................44444444444443433443751280605440668744 0000 .... 4434 3198 00 ..44 95 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 32 Day 33 INDIVIDUAL DOSE VOLUMES (inL) FOR MALE RATS Day 34 Day 35 Day 36 Day 37 Day 38 Day 39 Day 40 Male, V - 250 mg/kg/day I 666666666666666666444444444444444444111111111111111111112201110101011101930069634807629847042017271926560780 641058 666666666666666444444444444444111111111111111111011101111111583717812892427141695074252209 641164 0000 .... 4343 4969 0.45 0.45 00.. 44 01 000... 443 547 00000 ..... 43444 46446 0.44 0.38 0.40 0.40 0000000 ....... 4444444 3512870 0.45 0.46 00..4413 , 0.39 0.48 0.49 0.45 000 ...434 496 0.39 0.45 0.45 00.. 44 01 0000 .... 4433 5476 00.. 44 44 00.. 44 46 0.44 0.38 0.40 0.40 000 ... 444 315 0.42 0000000000..........34444444445399870618 ' 0.45 0000000000000000000000000000000...............................43434444444433444444443444444444969550154337644445171600205688 0000 .... 3444 9895 000000000000000...............444444444433444731672386698687 000... 444 851 00000000000000000 ................. 44554444455444444 33224684411796428 00000000000000000000000000000000................................4444444444344344444444445544444437167238669334868785146841179642 000 ... 554 228 000000......444444371867 00000000000000000000000000000.............................4444344534444444445544444444539332266286875146841179648428 0000000000..........44444444443712368676 00 .. 33 98 0000000 ....... 4444444 3678851 0000000000000 ............. 4554444444444 3411467964284 0.52 00 .. 54 28 000000 ...... 444444 371867 0000000000..........44443434443266968878 0000000000000 ............. 4444444445544 3351468441179 000... 444 642 000 ... 554 228 0000000000000000000...................44444444443434444447316872366963887851 000000000000000 ............... 445445444544445 324816644179422 0.48 Does no*contain TSCACBI 435 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ Day 41 Male, V - 250 mg/kg/day 666666644444441111111012121166030991204270 666666666666666666444444444444444444111111111111111111110111101010010111781371706257839484507169025686970178 666666666644444444441111111111111011111176282842599402242415 000000......444444367718 00000000000000000.................4444443443444444443146897523686868 00 ..45 41 0000 .... 4454 3791 000000 ...... 544544 282264 Day 42 00000 ..... 45454 90215 0.48 0.44 0.44 00 ..44 79 0.40 0.37 0000000.......44545343437188 00000 ..... 44544 70868 0.54 00..45 54 0.49 0000000 ....... 5555444 4401785 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 43 Day 44 Day 45 Day 46 Day 47 000000......445454890215 00 .. 44 44 0000000000000000000...................44554544445543444435744808346137887907 00000000 ........ 55454544 40549178 0000000000000000000000000.........................45445444543544444444354547438037468717989844080215 0000000000..........55455454444054174985 0000000 ....... 4444545 9458021 0.44 00000000000000000.................4455445444544433404738683479170788 0000000000..........55455454440454714598 00000 ..... 44545 95021 0000000 ....... 4444443 7844907 000 ... 534 188 00000000000...........5554444454444073468837 000000000 ......... 445554454 544085917 00000000........4454444544215980 00.. 44 79 00 .. 34 70 00000000000000000000000.......................5554545445445444444553440544917845380876374188 Day 48 00000 ..... 44545 59021 0.48 0000000000000000000...................54544445445344344440743884637197884470 00000000........4545445454917845 00 ..55 40 DuPont-4739 Day 49 000000 ...... 455554 711304 0000000000 .......... 5543455454 4017411605 0000000000000000000...................45554545555555554445554386103671100548 CompanySanitized. Does notcontain TSCACBit 436 .J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________ DuPont-4739 Day 50 Day 51 INDIVIDUAL DOSE VOLUMES (itlL) FOR MALE RATS Day 52 Day 53 Day 54 Day 55 Day 56 Day 57 Day 58 Male, V - 250 mg/kg/day 666644441111121109392047 0000....55443047 641200 0.51 641061 0.51 641162 0.45 641089 0.46 641137 0.50 641102 0.50 664411007960 00 .. 43 17 641141 0.44 641187 0.51 641148 0.51 641170 0.54 641065 0.50 641126 0.45 641058 0.44 641131 0.48 641176 0.51 664411101795 00 .. 55 31 641180 0.50 641117 0.56 Q g M $ 5 Im 666666666644444444441111111111101111111128427628592420944215 000000 ...... 455554 367108 0000.... 4555 5554 0000....55443047 00 .. 55 11 00000000000000000000 .................... 44554345555555444555 56001741141310548067 000000000 ......... 545544555 361085545 0000....55443047 0.51 0.51 00.. 44 56 0.50 0.50 0.41 _a 00 .. 45 41 00000 ..... 55544 40541 0000 .... 4555 1318 0.50 0.56 0.57 0.46 0000 .... 5554 3018 0.45 0.55 00 .. 55 45 0000000000..........54545544553047115600 0.41 0000000000000000 ................ 4554554555455545 4051314118406761 0000000.......55445553085554 00000 ..... 55445 03471 000000 ...... 454554 516001 0000000 ....... 4555544 4114054 00.. 45 81 00 .. 55 31 000... 555 067 000000000.........545544555361055854 00000 ..... 55445 30471 00 .. 45 51 0000 .... 4554 6001 000000000 ......... 455555444 411410548 0000 .... 5555 3106 0000000000..........55455554453761054855 00000 ..... 54555 25601 0.54 00000.....5445423829 0000000000000.............45555555445553923391650198 0000000000 .......... 5554544555 3928687766 00000000000...........5455555544425601422389 0000000000000.............54555545555453392961503189 00 .. 54 98 00000000........5554455532687766 0000 .... 5455 2560 00 ..55 14 0.48 000 ... 545 229 0.43 000000 ...... 545554 392918 000000000 ......... 455555554 335906198 00000000 ........ 55544555 36287766 o notcontain TSCACBf Animal number 641090 was sacrificedin extremis on testday 51._________________________ 437 I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 59 Day 60 Male, V - 250 mg/kg/day 666644441111111299307042 666444111102660120 664411018397 666666644444441111111100111180794477260180 666666666666666666644444444444444444441111111111111111111111100111111111110078928427681251376255252420940741916568 000000 ...... 545555 256014 0.48 0000 .... 4554 3229 00000 ..... 55545 32919 000000......555544336085 000000000000............555545555454316277669898 00000 ..... 55455 21560 0.54 00000 ..... 44554 39228 000000 ...... 455455 921389 0000000 ....... 5555545 3319650 0000000000 .......... 5555545544 7663627988 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 61 Day 62 Day 63 Day 64 Day 65 00000000 ........ 54454555 48925601 00 .. 55 22 0.43 000000......555554206145 00000 ..... 45544 39228 000000 ...... 554555 346716 00000.....4555533004 0000 .... 5554 7146 0000000 ....... 5545555 3336004 000000000 ......... 555455555 310067644 00 .. 54 33 0000....45559239 0000000.......55555443301568 . 0.51 0.59 0000 .... 5455 3299 000000000.........555545455319365801 0000000000000.............55565445455553750197594318 000000 ...... 445555 931948 0000000.......56555453015577 0000 .... 4555 3948 000000000 ......... 555564455 397157501 0000000000..........55554454556636287987 000 ... 554 398 00 .. 55 26 00000 ..... 55454 66778 000 ... 456 920 00 .. 55 48 00000 ..... 65545 06078 0000000000 .......... 5556546455 0627800984 0000000000..........56645554556009840782 Day 66 0000000.......55555543716046 00 .. 55 04 00 .. 45 33 0000000000000.............55556555444553175035819794 0000000000 .......... 5556546455 4080609278 DuPont-4739 Day 67 0000.... 5455 4671 00000 ..... 55555 36004 00 .. 54 33 00000000000000000000000.......................5645554565555556455445560924078038157509319748 CompanySanitized. Does notcontain TSCACBf 438 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________ Day 68 Day 69 Male, V - 250 mg/kg/day 666664444411111211210309904270 664411016612 666666666664444444444411111111111011111010107624409883705618207976 666666666666666664444444444444444411111111111111111111111101011111106427528897812173542091242550749618 00000 ..... 55554 37416 0.56 00000.....5455533400 00.. 45 94 0.53 0.58 00.. 54 19 0.47 0.51 0.55 0.57 00..5535 000... 664 009 00 .. 55 82 0.54 0.50 00.. 54 87 0.60 0.56 000000......555554341676 000 ... 555 400 00 .. 45 33 00 ..45 94 0.53 0.58 0.51 00 ..44 97 00000000........4665555593005157 0.52 0.58 0.54 000 ... 455 780 0.60 0.56 Day 70 00000000000...........5455555554655646214680 000...555516 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 71 Day 72 Day 73 Day 74 000000 ...... 555546 446680 00000 ..... 45555 56521 00000000000...........4555555556455614462608 00000 ..... 55546 44680 0.56 00000 ..... 45555 52165 00 .. 45 86 0000 .... 5565 4604 00000 ..... 45555 65521 000...555516 000...555516 000... 555 165 000...555516 Day 75 000000......555564644608 00 .. 55 12 00 .. 55 56 0.45 000 ... 555 516 DuPont-4739 Day 76 000000 ...... 565554 404668 00000 ..... 45555 52165 000 ... 555 516 ? Does notcontain TSCACBl 439 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 77 Male, V - 250 mg/kg/day 666644441111112190930274 666644441111010266801290 664411110327 666666666666666644444444444444441111111111111111001110111110101142793717818476251460169507780568 666666666444444444111111111110111111892427568252209144 000000 ...... 546555 691468 00 .. 55 33 000...554 765 000 ... 555 397 Day 78 0000 .... 5465 6914 00.. 55 68 00000.....5554533765 000 ... 555 397 INDIVIDUAL DOSE VOLUMES (BlL) FOR MALE RATS Day 79 Day 80 Day 81 Day 82 Day 83 0000 .... 4556 9461 00.. 55 68 00000 ..... 55554 33765 000000 ...... 555546 646891 00000.....5554533675 000000 ...... 555546 664891 00000.....5555433765 0000 .... 5456 9461 000000 ...... 555555 336786 0.45 000000 ...... 456555 961468 0000 .... 5555 3376 0.45 000...555397 000...555379 000...555397 000...555397 000...555379 Day 84 00000000000 ........... 55555465554 36593918656 000 ... 555 919 DuPont-4739 Day 85 00000000000 ........... 55465555554 33915698566 000 ... 555 199 Does notcontain TSCACBI 440 0es notcontata t*$ca csfr H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________ Day 86 Day 87 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 88 Day 89 Day 90 Male, V - 250 mg/kg/day I 666666444444111111201211063099014270 666666664444444411111111110100116083794822976017 666666666664444444444411111111111110111010117813717625450716905688 0000000.......55546553699165 0000 .... 5554 3586 000 ... 555 991 000000 ...... 465555 916965 00000 ..... 55455 53638 00 .. 55 91 0.59 00000000000...........5545555546535638696915 000... 555 199 000000 ...... 546555 991566 00000 ..... 55455 38563 000 ... 555 991 00000000000...........5455655655533760902566 000 ... 555 991 666666666644444444441111111111111111011167842285924942042152 441 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 0 Day 1 Male, VII - 1000 mg/kg/day 666644441111220129503571 664411008667 664411019372 666666666666666666666666666666666666644444444444444444444444444444444444441111111111111111111111111111111111111101021100102210110210211211001212112160735969596003871911075814869615415186570769343887907062238221554273330069 010110 ...... 909019 970900 10 .. 09 08 1100111110001100111111101101111100011.....................................09119012089911990002101900002912999110800400009950017000000050000048008600 0110 .... 9009 7009 10101100111111100000111111101101................................1909019911102018999900021019900009080048000000009951700000058000 11100 ..... 02199 00084 1110 .... 2119 0006 Day 2 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 3 Day 4 Day 5 Day 6 0110 .... 9009 7009 01101 ..... 91090 90080 1001111011111000011111110010111010..................................19910129101008999021010090219990924080000500099170000000050004608080 11.. 11 00 10010 ..... 09909 70909 1.10 1.00 01100111110001..............9019910120189980048000000995 01011 ..... 91900 10700 1111101101 .......... 0210190090 0000050080 1111000 ....... 0212999 0008460 11 .. 11 00 0.97 1010110 ....... 0909109 0909008 11010111100101010.................0191901209919190800408000095010790 11111111100...........0021010009900000000058 111110010 ......... 021119929 000008406 01010 ..... 90909 70909 1.10 10 .. 09 08 1100111110001010111111111100011101011.....................................01991012089919190002101000999990212110048000009950107000460000000588000000 0110011011 .......... 9009910901 7009900800 00111111110000011111110110011101011...................................9910121100899990010202190190990291148000000099510000047000000508800600 442 Day 7 1111 .... 1222 0000 1.20 1.20 1.20 1.20 1111111111111 ............. 2311333421213 0000000000000 11 .. 31 00 111111111111 ............ 232243331222 000000000000 1.30 111111111 ......... 234221334 000000000 DuPont-4739 Day 8 11 11 11111111111111 1111111 1111111111 1111111111 .10 .20 .20 .20 .20 .20 .20 .20 ..2300 .10 .....1333400000 .20 .10 ........,2313231200000000 .,20 .,40 ..30 ..30 ..30 .,10 ..20 .,20 ..20 ..30 ...,,, 342 000 .,20 ..,, 4200 ...,,, 331000 TSCACBI { I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________ Day 9 Day 10 Male, VII - 1000 mg/kg/day 666666666666666666666666644444444444444444444444441111111111111111111111111121011202010211010000201290395961501908693673620953793769248065677267083157 666666664444444411111111011110121585877122200870 666644441111021114861554 666666664444444411111111122101124015968133332796 111111111111111111111111111111111111....................................332223332243113122123343132222212122000000000000000000000000000000000000 1111 ....2342 0000 11111 ..... 33241 00000 11111 ..... 22221 00000 1.20 111111111111............113334231222000000000000 111 ...213 000 1111111111111 ............. 3312222323413 0000000000000 11111111111...........3334224132200000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 11 Day 12 Day 13 11111 ..... 22122 00000 1.20 111111...... 122222 000000 111111 ......122222 000000 111111111111111111..................131321233423222311000000000000000000 11111111111...........2221243333200000000000 11.. 32 00 11 .. 43 00 11.. 22 00 1111 .... 3413 0000 11 .. 22 00 11111111111...........2123211334300000000000 11.. 13 00 111 ... 321 000 111111111 ......... 331232243 000000000 111111111111............133422423232000000000000 111111111111111111111111111111111111111.......................................333422413122232232243311313322133422231000000000000000000000000000000000000000 443 DuPont-4739 Does no!contain TSCACBS J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________ Day 14 Day 15 Male, VII - 1000 mg/kg/day 641201 666444111021925537 664411006876 641097 666666644444441111111110012135670932767560 666666644444441111111010201096915163962408 ' 666666644444441111111110220193800773907887 641112 666644441111112158152200 641211 641145 641185 666644441111001269614276 666644441111212115083339 641143 1111 .... 3343 0000 11 ..44 00 11111 ..... 44452 00000 1.20 11.. 65 00 11.. 46 00 1.40 1.20 1.40 11 ..35 00 111111 ...... 255544 000000 11.. 65 00 11..45 00 . 11.. 33 00 1.40 1.40 1.50 111...457 000 1111 .... 5336 0000 11 .. 45 00 111 ... 333 000 1.40 1.40 1.40 1.40 1.40 11 ..45 00 11 ..22 00 11 ..65 00 1.40 1.60 11 ..42 00 1.40 1111 .... 5325 0000 1.50 1111 ....54640000 ' 1.50 111111 ......543344 000000 1.50 1111....5475 0000 1111....3364 0000 1.50 INDIVIDUAL DOSE VOLUMES (rtlL) FOR MALE RATS Day 16 Day 17 Day 18 Day 19 1.30 1.30 11111 ..... 44344 00000 1.40 1111 .... 4522 0000 1111 .... 6546 0000 11 ..42 00 1.40 11 ..35 00 111 ... 255 000 . 1111....45460000 1.50 111... 543 000 1.30 11.. 44 00 1.50 11 .. 45 00 111 ... 537 000 111 ...634 000 1.50 111111111111111111111111111...........................333444444522352465464245554000000000000000000000000000 11 ..65 00 1111 ....5433 0000 11 ..44 00 1.50 111111111 .........457536345 000000000 1111.... 3334 0000 11.. 44 00 111111111111 ............ 444522654642 000000000000 111111111111111 ............... 243555544536543 000000000000000 11111111111 ........... 45457536344 00000000000 1.50 111111...... 333444 000000 111111111111111111111.....................445224262556443555444000000000000000000000 111111 ......655433 000000 11111111111 ........... 44545753634 00000000000 1.50 Day 20 11111111........3334444400000000 11 .. 45 00 11111111 ........ 26254642 00000000 111111...... 435255 000000 11111111111 ........... 54453446534 00000000000 111111111......... 545753634 000000000 1.50 444 DuPont-4739 Day 21 111 ... 454 000 101... 555 000 111111111111111111111111111111111111111.......................................665643875854777676965847354569765455666000000000000000000000000000000000000000 Day 22 1111111111111111111...................45556645564387585350000000000000000000 11111111111111 .............. 77765697654474 00000000000000 1.50 111111111 ......... 686645569 000000000 11.. 67 00 Doesnotcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 23 Day 24 Male, VII - 1000 xng/kg/day 666666644444441111111221000002598691375677 641132 666666644444441111111101021167935066760759 666666666444444444111111111210100022199650190233848067 666666666666666666666444444444444444444444111111111111111111111121101120102111121102504113878975514861168333239072282015546079 1111 .... 4455 0000 1.50 1.50 1.60 1.60 1111....5643 0000 11 .. 87 00 1.50 1.80 11111 .....53547 00000 11 ..47 00 1.70 1.60 1.50 11111 .....6976700000 , 11 ..54 00 11 ..55 00 11111111 ........ 66984665 00000000 1.60 1.70 1111 .... 4455 0000 1.50 11111111111...........5656643878500000000000 111111111 ......... 375544776 000000000 11 ..56 00 1111 ....9776 0000 11111111111111 .............. 54569584675666 00000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 25 Day 26 Day 27 Day 28 1111 .... 4455 0000 11111111111111111111111.......................5566564387585354764775600000000000000000000000 11.. 97 00 1111.... 7654 0000 111111111111 ............ 675566696584 000000000000 1111111111111111................44555566564387580000000000000000 111111111 ......... 547354776 000000000 111111 ...... 445555 000000 11111111 ........ 66564387 00000000 11 .. 58 00 111 ... 553 000 111111...... 474776 000000 11111111111111111111 .................... 75697765456665846596 00000000000000000000 1.50 1.60 1.90 . 1111.... 7765 0000 1.40 1.50 1.50 1.60 111... 669 000 1.60 111 ... 458 000 1.60 1.70 111111111111211211111111111211111111111112111.............................................556655767440960568665488767086785775757986069000000000000000000000000000000000000000000000 445 Day 29 11111111111121121111111.......................5556657667440906566854800000000000000000000000 111112111111 ............ 876757507867 000000000000 1112111111 .......... 9860569778 0000000000 Day 30 11111 ..... 55566 00000 1111111211211 ............. 5766744096065 0000000000000 1111111 ....... 6584887 0000000 112111111111211111 .................. 670856778986057757 000000000000000000 11 ..69 00 DuPont-4739 Day 31 11.. 55 00 11..56 00 11111111211211111111111.......................6567764409606565848876700000000000000000000000 12111111........60787557 00000000 211111111 ......... 607789856 000000000 1.90 Does nocontain TSCACl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________________ INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 32 Day 33 Day 34 Day 35 Day 36 Day 37 Male, VII - 1000 mg/kcj/day ! 666664444411111220010289513657 641067 641097 666666666666644444444444441111111111111202100110111019601963593672395068076267 666666664444444411111111100112029387705039087748 666666666666666644444444444444441111111111111111221101211021211101589614861158513339271554602202 641143 11 .. 55 00 1111111 ....... 5657666 0000000 11 .. 47 00 111121111111111121121111........................567078757887684409606565000000000000000000000000 2111111111..........60958689770000000000 111111 ...... 566555 000000 1.70 1.60 1.60 21121111 ........ 06440967 00000000 1.50 1.60 1.50 1.80 1111 .... 8487 0000 1121....07670000 ' 11111.....6585700000 1.70 1.70 1111 .... 9878 0000 21111 ..... 05696 00000 11111111 ........ 76655556 00000000 111112121111111111..................488768060656546749000000000000000000 12..07 00 11 .. 78 00 1111 .... 5567 0000 12111111111...........9560698877700000000000 11111 ..... 76776 00000 11.. 57 00 22112111121111111111111122111111112111......................................0268719888815687989875990175769855278700000000000000000000000000000000000000 2111111111221111111121111111111111..................................18879987569019595785527768775777660000000000000000000000000000000000 1.80 1.80 221111121.........207689818000000000 2211111111211111111...................01757775527886775760000000000000000000 1111111 ....... 9987695 0000000 1211111 ....... 7591988 0000000 11111 ..... 88688 00000 21 ..19 00 22111 ..... 02687 00000 Day 38 1111 .... 6767 0000 1.70 11.. 57 00 1.80 1111 ....78550000" 2.20 21.. 7000 2111 .... 57710000 1.60 1.90 1111 .... 9859 0000 11 .. 97 00 211111...... 758981000000 1.60 11 .. 88 00 11.. 88 00 21.. 9100 22111 ..... 02687 00000 aTestsubstancewas observedon lips;animalmay nothavereceivedtheentiredose. 446 DuPont-4739 Day 39 11111 ..... 76776 00000 1.50 1.70 11111.....5785800000 2.20 21.. 7000 211 ... 571000 11 ..76 00 11111 ..... 98599 00000 1.70 1.90 211...891000 1111 .... 5687 0000 11 ..88 00 11 .. 88 00 12.. 9100 21211 ..... 06872 00000 Day 40 111111 ...... 676775 000000 1.70 11111.....5857800000 2.20 21.. 7000 2111 .... 57710000 1.60 1.90 111 ...599 000 111 ... 978 000 21111 ..... 8789100000 111 ... 856 000 1.80 1.80 1.80 21.. 9100 1.70 121 ... 862 000 2.00 f.Does notcontain tsca cri H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 41 Day 42 Male, VII - 1000 mg/kg/day 666666666666666666444444444444444444111111111111111111220100011010211102029580693673596191135765772670769062 641068 i 666666666666664444444444444411111111111111012021010121119907503815857133774890022082 664411211415 666666666644444444441111111111102021211191504861682333354679 11 .. 76 00 11.. 67 00 1.70 1.50 1.70 1.80 11.. 78 00 1.50 12 ..52 00 2.00 12111.....71757 00000 11 .. 96 00 111111211111111211..................599879188751968888000000000000000000 112112 ...... 926807 000000 1111 .... 7777 0000 1.80 1.60 111111......898856 000000 22 ..31 00 12 ..81 00 11 ..86 00 1.70 1.70 211 ... 059 000 2.00 1.80 1221 ....02980000 ' 2.00 1.90 21111111 ........ 27678999 00000000 112112 ......980736000000 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 43 Day 44 Day 45 Day 46 1111111111112.............78777689885630000000000000 21211 ..... 18186 00000 1.70 121121221121............709508028909000000000000 11.. 76 00 211111211211 ............ 073688999297 000000000000 111111111111221211112112211212111111112112112.............................................777786888956183186770590088290976789929897360000000000000000000000000000000000000000000000 111111111111222111..................777786898856311886000000000000000000 1.70 1221111221211111................70059880290976780000000000000000 1.90 1.90 12.. 92 00 112121 ...... 793608 000000 11 .. 77 00 11.. 77 00 1.80 1.60 111111 ......988568000000 2212.... 3181 0000 1.80 1.60 1.70 12 .. 70 00 112 ...590 000 1.80 2121 .... 0829 0000 2.00 1.90 11 .. 76 00 1.70 111... 899 000 12 ..92 00 1.90 121 ... 736 000 1.80 2.00 447 Day 47 1111111111 .......... 7777868988 0000000000 11.. 56 00 222111112112112222111111111211112.................................311886770590880203997706899929768000000000000000000000000000000000 m DuPont-4739 Day 48 111111 ...... 777786 000000 1111112221111 ............. 8988563118867 0000000000000 1211212121211111................09750808290976780000000000000000 1.90 211212111 ......... 297360998 000000000 Day 49 111111111111222111..................777786998966521987000000000000000000 1.80 121221122221............007609904019000000000000 11122222112112 ..............87700003984791 00000000000000 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 Day 50 Day 51 Male, VII - 1000 mg/kg/day f 666666666666444444444444111111111111001110021020793635260958772607371576 666644441111211110960569 666666666444444444111111111102212000950031996348792368 664411008708 666666666666666664444444444444444411111111111111111221011211021111120159684861715851133327955467222010 641143 1111.... 7777 0000 1.80 1.60 1.90 111... 989 000 11.. 66 00 221... 529 000 2.10 1.80 1.70 1.80 1.70 221 ... 006 000 2.00 1.90 21..09 00 2.40 2.00 21 .. 91 00 '11.. 87 00 1222 ....7000 0000 2211....9803 0000 2112 .... 7149 0000 1111 ....7777 0000 1.80 1.60 1.90 1.90 111122......986652 000000 211...189 000 1.70 1.80 2121 .... 0067 0000 2.00 2112....09490000 2.00 2.10 1.90 1.80 1.70 1.70 2.00 22.. 0000 212211 ...... 740398 000000 1.90 2.10 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 52 Day 53 Day 54 Day 55 1111 .... 7777 0000 221222111112212111111111........................900040699665918787298869000000000000000000000000 22121122221221111.................1384790009001987700000000000000000 1111111 ....... 9677778 0000000 1111.... 8996 0000 2212222111111.............00067875218690000000000000 2211 .... 0994 0000 122 ... 901 000 2122222111111.............49000039878770000000000000 2.10 1221111211111221211111111.........................60907708965291898677786970000000000000000000000000 2112122211 .......... 7009940187 0000000000 211222112.........749003980000000000 2.10 11111 .....77778 00000 1.60 1.90 1.90 1111....96680000 . 221111221 ......... 078718529 000000000 21 .. 06 00 2.00 1.90 122... 904 000 22.. 01 00 1.90 11.. 87 00 222221 ...... 000037 000000 1112 .... 7984 0000 1.90 2.10 Day 56 1111.... 8887 0000 11 .. 79 00 2211121111221 ............. 8830908967529 0000000000000 222122221121 ............ 010904129671 000000000000 1111 .... 7988 0000 21222212........5703080000000000 21 .. 19 00 Day 57 211112111122211111 .................. 098963279087589887 000000000000000000 221111122221222111..................049887991210100687000000000000000000 221211222 ......... 108579300 000000000 Day 58 1222211112122222221111121111111111..................................79012988416010887530279089679798880000000000000000000000000000000000 1.90 222221112 ......... 503087900 000000000 2.10 Does notcontain TSCACBl 448 Does no!contain TSCACRi .J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 59 Day 60 Male, VII - 1000 mg/kg/day 666666664444444411111111122010003209586923157677 666666666666666666444444444444444444111111111111111111101210120200211100903896730155096196379036708247569068 664411107778 666666444444111111211112115851122200 666666666664444444444411111111111121210201114150848661933339557462 11111 ..... 88978 00000 1.70 1.90 2.00 1.80 11 .. 96 00 12222 ..... 75023 00000 111 ... 889 000 21 .. 17 00 2122 .... 0601 0000 1.90 2.00 2.40 2.10 2.20 1111....87980000 ' 12.. 90 00 2.00 2.00 212 ... 380 000 211 ... 795 000 2.10 11111 ..... 87988 00000 22212221112111122221111.......................4109016087790867530298900000000000000000000000 221 ...129 000 22222111121...........5080038790800000000000 11 .. 97 00 2.10 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 61 Day 62 Day 63 Day 64 111111121111............887979089678 000000000000 22212221222111122.................4109016018870295300000000000000000 2221211222211111................15793080009887920000000000000000 1111111 ....... 7888799 0000000 222112121122221111..................010687120675309889000000000000000000 22112222212111111222....................1957080003198879429000000000000000000000 1111111 ....... 8988979 0000000 2.00 22222211111212212222111211..........................2998800142261282989963107600000000000000000000000000 22221211222...........2908680401100000000000 11111 ..... 88989 00000 211 121 ......097970000000 . 1222 .... 1663 0000 2.20 1.90 22122111 ........ 02612898 00000000 2.00 22.. 14 00 22.. 22 00 11.. 99 00 11 .. 88 00 2222 .... 0110 0000 22121.....08684 00000 1.90 2.20 aTestsubstancewas observedon lips;animalmay nothave receivedtheentiredose. 449 Day 65 22211111111212112 ................. 12969888979090763 00000000000000000 22221212211...........0014926128800000000000 22222111122222111.................2914088680102299800000000000000000 DuPont-4739 Day 66 11111112........ 98889790 00000000 122221112 ......... 901297636 000000000 11222222111212211.................9800142298618229800000000000000000 2.00 22 ..10 00 22112221........2968081400000000 Day 67 1111111 ....... 8897998 0000000 21211 ..... 09076 00000 2.60 22221111 ........2312898900000000 " 2212 .... 2016 0000 2.00 22 ..14 00 2.20 2.20 1.90 11 ..98 00 1.80 222 ... 100 000 222 ...014000 2111 .... 9688 0000 2.20 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________ DuPont-4739 Day 68 Day 69 Male, VII - 1000 mg/kg/day 666664444411111220102095831576 641067 666444111101396276 664411103707 666666666666666666666664444444444444444444444411111111111111111111111121101122110002002102115118901577389519106509601223702879037062584869 666666444444111111110021686941754256 666644441111212105183339 641143 1111 .... 8988 0000 1.90 112211 ...... 790097 000000 222222222211211211..................421120062892661983000000000000000000 21 ..29 00 22122112222111..............2698408010198800000000000000 11111 ..... 89889 00000 1.70 1.90 2.00 1.90 2.00 2211121112221.............12629886619730000000000000 22 ..20 00 2.00 22..4100 ' 2.20 2.20 1111....9898 0000 2.00 2.10 22 ..01 00 221 ... 084 000 2.60 11 .. 98 00 2.20 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 70 Day 71 Day 72 Day 73 11112.....9990800000 11211.....9909800000 21111.....0999800000 11211.....9809900000 1.80 1.80 1.80 1.80 2.00 2211 .... 0179 0000 2221 .... 7147 0000 2.00 2.10 211 ... 097 000 1222 .... 7741 0000 2.00 2121 .... 1907 0000 1222.... 7741 0000 2.00 22111222 ........1977741000000000 - 2.20 221222212.........380650911000000000 222212221.........068502911000000000 2.30 2.20 22212221........0806159100000000 2.30 2222122221 .......... 0368021159 0000000000 Day 74 112111 ...... 980998 000000 2.00 2121.... 1907 0000 1222 .... 7174 0000 2.20 2.10 2122 .... 0951 0000 2221 ....36800000 " Day 75 111211 ...... 998089 000000 2.00 21.. 19 00 21 ..07 00 1222 ....7741 0000 2221221222..........03685092110000000000 Day 76 111121 ...... 998908 000000 2.00 21212122 ........ 19077471 00000000 22222 ..... 50121 00000 2211....06890000 2.30 CompanySanftfeed. Dee net contain TSCACSI aTestsubstancewas observed on lips;animalmay nothave receivedtheentiredose. 450 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 77 Day 78 Male, VII - 1000 mg/kg/day 666644441111220120593175 666666666666666666666666666666644444444444444444444444444444441111111111111111111111111111111210011111212100210001021121001014971851587039863709615019369651537220020879367275692480608767 666666666644444444441111111111212110120104158916683333926745 21221111 ........ 19109998 00000000 2211222 .......0087732 0000000 222211222.........079629212000000000 2.40 122211222211211 ............... 870073299109918 000000000000000 1222212222..........90476292120000000000 INDIVIDUAL DOSE VOLUMES (inL) FOR MALE RATS Day 79 Day 80 Day 81 Day 82 12211.....1909900000 22111.....0199900000 21112..... 09991 00000 21112..... 09991 00000 1.80 1.80 1.80 1.80 21..1900 21..1900 21..1900 21..1900 2222211 ....... 2730087 0000000 2221122 ....... 2008773 0000000 2212221 ....... 0832077 0000000 22..0000 . 11.. 87 00 222... 732 000 2212122222..........04997622210000000000 2222 .... 6212 0000 222121......047992000000 2222121222..........04962971220000000000 2222 .... 6212 0000 222211 ...... 704992 000000 Day 83 21112 ..... 01999 00000 2211222112 .......... 0087732819 0000000000 2221221222..........40792962120000000000 DuPont-4739 Day 8< 211121222211222 ...............079808010186732 000000000000000 Day 85 2111....79800000 21.. 8000 2.00 2.10 2.00 211... 861000 22 .. 73 00 2.20 2222 .... 1512 0000 2.20 2.10 22.. 5100 1.90 1.90 22111 ..... 29788 00000 2111 .... 9788 0000 2.20 8*B ted Does notoontaln TSCAcoi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________ Day 86 Day 87 Male, VII - 1000 mg/kg/day 666666444444111111220100209568315776 666666664444444411111111101100216733950967207756 666644441111211016192906 666666666666666644444444444444441111111111111111102002100111112299071585165038713377222018489080 666666666664444444444411111111111211210201111450461968833335462795 211121 ...... 079808 000000 222211222 ......... 011086732 000000000 222211 ...... 521981 000000 1221 .... 9278 0000 211121 ...... 079808 000000 222211222 .........010186732 000000000 22222111 ........ 78598211 00000000 21 .. 29 00 INDIVIDUAL DOSE VOLUMES (mL) FOR MALE RATS Day 88 Day 89 Day 9( 2111 .... 0798 0000 2122221122 .......... 8010108673 0000000000 2.20 21121 ..... 07908 00000 1.80 222211222 ......... 010186732 000000000 1111 .... 8998 0000 22212211222 ........... 00180186732 00000000000 2222211211 .......... 2211598789 0000000000 2222221111 .......... 1572219889 0000000000 22221211 ........ 21159788 00000000 12 ..92 00 452 DuPont-4739 fla m m ,S m i t e ,1 D o es n o i c o ,, m ,, t s c a c b i '"ri-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ Day 0 Day 1 Female, II - 0 mg/kg/day 666666444444111111223223988594334704 666666666666666664444444444444444411111111111111111333333323322322227312844309332484412045155946780895 666666666666666666666644444444444444444444441111111111111111111111232334332223332433332368963055288815044058606344103951997539688816 0.71 000... 778 521 00..7733 0.78 0.85 00000 ..... 77877 29571 0.70 00.. 77 54 0.76 0000 .... 7778 3251 000 ...787 618 00 ..77 66 0.78 00 .. 77 66 00.. 77 57 00..87 75 0.74 0000000 ....... 8787887 1514100 0000 .... 7777 5970 0000000000000000................77787777777787874353291057521851 00000000000000000.................7778877777777777857571666636828651 00 .. 77 44 0000000000..........77778887785097110501 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 2 Day Day 4 Day 5 Day 6 000000......777787331521 0000000000..........77777787785421085795 0000000000000000000...................78777777778778777774745567686186132656 0.81 000000000.........778778877501197050 00000000000000..............7777777788787720912338557115 0000000000000000000...................78777777877778777775757686616132684655 0.74 0.74 0000000000..........78777877881970505011 0.71 000000000.........778787877335218575 0000.... 7777 2910 0000000000000000000000000000000...............................78777888777787777777778778777775197011050447575666382618614655 000000000000............777787778787372359152185 0000 .... 7777 5410 0.76 0000000000000000................87777777787778775766573626186815 00 .. 77 44 0000000000..........78777887785197010501 000000000000000000000000000000000.................................787777777777877787777778788777777576576366826186510543911523185572 000000000000............787778778787519700501414 453 Day 7 000000000000............999888788888395218066140 00 .. 77 56 0.83 0000000000..........89888788883116633248 00000000........9888888882555887 0.82 00000000000...........8988788898843968127747 DuPont-4739 Day 8 00000000000000000000000000000000000...................................8889888888889888788887788978998888824285885753661333248165380952161406 0.87 00 .. 88 77 0000 .... 9898 3126 000 ...878 498 I ' (Km jjlj H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ________________________________________________________DuPont-4739 Day 9 Day 10 Female, II - 0 mg/kg/day 666664444411111222335984870344 641293 666666666666666666666666666666666666666444444444444444444444444444444444444444111111111111111111111111111111111111111233433322332324232333333333322333232222630684455289080603815812752940833434448410639639514893162975804188459567059518 000000000000............898789988888630952181406 00 .. 77 65 0000 .... 8888 3332 00000000000000000.................9888888889888878882427558835616481 0.87 000000000.........887998888423981677 000000000000000000..................888878779988888898233366539218006541 0.84 00 .. 87 18 000000000000000000000000........................879889888898888888888988438912677728455288715366 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 11 Day 12 Day 13 Day 14 Day 15 000000...... 888878 061495 000000000000............878888799988333252310668 0.84 0000000000000000000000......................89888888888889988888876122477727588835511668 0000....89874398 00000 ..... 87888 49601 00000000000000000000....................8987888888887978998831633816324366552180 000000000000............888888988888724752858857 00000000........8987988843981267 0000.... 8888 0614 000 ... 897 529 0000000000..........88877988893336531806 000000000000000000..................888888988988888887242858875315216648 0000000000..........89879888883984267177 000000 ...... 999998 046048 001110000.........879990018721180008 0.88 000... 989 187 000 ... 889 540 10.. 09 06 01000010010000000000....................8909899909809899998935057904301604915588 0.90 0000.... 9989 0486 00 .. 99 04 1.00 000001100000000...............888899999890187578402111870088 10 .. 09 06 0110000000000000................99800999898999899070043165549188 10 .. 09 05 000 ... 899 305 Day 16 000000 ...... 999998 044608 001000000001100...............889919798889008541701817882008 010000......990989580680 10000000 ........ 09889999 91301654 1000000010..........89099989903005507940 Day 17 0000000111100000000000000.........................98988908900198979889999896815400782181780008604084 01000001100000000000....................9809899909099989899903054957003104916585 OftapanySanflfred, Does notconjoin too. 454 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 18 Day 19 Female, II - 0 mg/kg/day 666644441111222385943704 641384 641293 641249 666444111322344505 666666666666644444444444441111111111111333233232332307342812894339121850484567 666666666666666666666644444444444444444444441111111111111111111111422333423223233233333398630605285860085445814341063351581689996897 000000 ...... 999899 044680 0011100000000 ............. 8990019897988 1780002818178 00010010010000000010000000..........................8999099098098999899909898835950040160073549158068054 00000 ..... 99989 04086 0.94 11.. 00 00 0100000000 .......... 8991897988 2180818178 010001100000000000100000000...........................809999989009998998098999988305050479300911654068580754 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 20 10000001 ........ 09990899 00440860 10.. 19 02 00 .. 98 18 0000000 ....... 7989898 8171878 10001000000000010001000000..........................9890989909909998989999088835047950003015491668500854 DuPont-4739 CompanySanitized. Doesnotcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________ Day 21 Day 22 Female, II - 0 mg/kg/day 666664444411111222335984870344 666666666666644444444444441111111111111222233223232394443084933843950595146785 666666666666666666666666666444444444444444444444444444111111111111111111111111111333333422333323333332332242302758155885289062186044063234189753399514068081696841 01010.....9190960504 0111100000000.............92102999899998000005667908 1111001100 .......... 0090009099 0060240080 00 .. 99 94 111 ... 011 000 0010101011 .......... 9991901910 3140800900 00 .. 98 45 0.97 1.10 10 .. 09 50 0.94 0.98 1.20 11100 ..... 12099 00005 0.86 00000 ..... 99999 67098 1.00 0.92 110 ... 009 400 1.00 0.96 01 ..0908 . 1.00 0.99 1110 .... 0119 4000 00.. 99 14 1.10 0.98 110101 ...... 009191 300090 0.85 0.94 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 23 Day 24 Day 25 Day 26 Day 27 01100011 ........ 91099921 56004800 11.. 20 00 000000 ...... 989999 066570 00100 ..... 99099 98024 11 .. 00 00 100110011100 ............ 099009901199 068009400104 10101011 ........ 91019019 30008009 00 .. 89 54 01010.....9190960504 0.98 1.20 11100 ..... 12099 00005 0000 .... 9899 0667 00.. 99 98 1.00 00 .. 99 24 111... 000 000 0.96 01.. 90 80 1001 .... 0990 0940 11..11 00 00.. 99 14 1.10 0.98 11110000 ........ 01109998 30000495 0.96 1010 .... 1909 0504 0111100000001111100000 ...................... 9212099899009900099999 8000005669002468080007 10011100........0990119909400014 1011110000..........01919109983004908005 100100111101110000000001001100111.................................199099212090009899909999990909011065048000005662809000709840604000 0111110000 .......... 9101109999 4301000089 00.. 89 54 010100......901999600584 1.20 1110000001011100110100001100............................12099899909000990090999911990000508240046679040006800901 1011110000..........19011099890380000954 456 Day 28 011111111111011110..................921101133001800019900000000000080009 1.10 1111111011111111 ................ 0111110911112300 0000000900000000 1111111110 .......... 2191100101 3000000000 DuPont-4739 Day 29 011111111111011...............921101313000180900000000000080 111101011 ......... 010191911 900000900 11111111111 ........... 11111013020 00000000000 11111 ..... 01101 00000 1110 .... 2190 3000 1.10 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________________________________________________ DuPont-4739 CompanySanitized, Doesnotcontain TSCAC5I Day 30 Day 31 Female, II - 0 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111333422223322332433333332322223323233222332333863065528985080464073819855943444308248219483341063951495386916812973387456950595418800447 01111.....92110 90000 1.10 111...133 000 111 ...001 000 0110 .... 8009 8009 1.00 1.10 101... 190 090 1111 .... 1111 0000 111 ... 111 000 1.10 111... 021 000 1.30 1.00 1.00 1.10 1.10 1110111.......91020013000000 1.10 110111 ...... 019211 009000 111111 ...... 013130 000000 0110 .... 8009 8009 111111101.........111111900000000900 111111111111111111..................120101010001111231000000000000000000 01 .. 91 30 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 32 Day 33 Day 34 Day 35 Day 36 1111111011001111 ................ 1313001800992110 0000000800990000 111111110111............111111190110000000090000 11 .. 01 00 11 ..12 00 1111011111111.............19021100130010300000000000 11111111111101111111010011..........................1110110119000920131318091100000000099000000000080900 111... 111 000 111111 ...... 000123 000000 1011111111..........91100102113000000000 0.99 1111 .... 2011 0000 11111110 ........ 01313018 00000008 11 ..00 00 0.99 1111111111111111110...................11110230011111011900000000000000000090 1111110111..........21190101103000000000 111111111110111111..................111141310190001210000000000070000000 11111111111...........2211111220000000000000 11 ..01 00 11.. 12 00 11111101101...........1211910139100009000060 1.10 1111111111111101 ................ 3000912101141110 0070000000000000 11 .. 11 00 1111111.......11012200000000 11111101111111111110....................2119110111131291122000090000000006000000 Day 37 1111 .... 1201 0000 111111110111 ............ 141310190001 000000070000 11111111111111111.................2201111201211120100000000000000000 0.96 1111011111..........91121101139000000000 1.10 Day 38 1111111111111101 ................ 1131010090121410 7000000000000000 1111111111111.............21112121210010000000000000 111... 011 000 111110111011............119102112913900000000060 1.10 457 Does notcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ Day 39 Day 40 Female, II - 0 mg/kg/day 666666666666666664444444444444444411111111111111111332233222222223323084943944488948559514563095830447 666666666666666666666666666644444444444444444444444444441111111111111111111111111111243332232333223334233333333363068895526044080851385273216104314395169689385729841780 1111 ....1210 0000 1.10 1.10 1.40 1.10 11 .. 13 00 11111111110...........0011200019000000000070 11 ..12 00 1.10 1.10 11.. 11 00 1.20 1.20 01111.....9210160000 1.10 1.30 1.10 1.10 11..20 00 11 .. 11 00 10.. 19 09 1.10 1111 .... 1012 0000 11 .. 11 00 1.40 1.10 11101 ..... 10193 70000 111 ...000 000 1111 .... 2011 0000 1.00 111 ... 211 000 1.10 11..1100 1.20 111 ... 102 000 1.10 1.20 110 ... 139 006 1.10 1.10 1.00 1111 .... 1112 0000 0.99 1.10 INDIVIDUAL DOSE VOLUMES (itlL) FOR FEMALE RATS Day 41 Day 42 Day 43 Day 44 Day 45 1111 .... 1021 0000 111 ... 141 000 1111111111111011................12001120000191130000000000007000 111111111.........112012111000000000 110111111101............911121031921900000000600 1.10 11111111111111111111111111011111111...................................3011122222212211122101141091411132100000000000000000000000000800000000 1110111111..........11921220310090000000 111111 ...... 111321 000000 1.40 11111 ..... 10114 00000 10 .. 09 08 11.. 11 00 11.. 12 00 1111111111111111111...................10131123222212221120000000000000000000 1101111.......92112029000000 1.10 111111 ...... 132111 000000 1111111101111.............22111001914140000008000000 11 .. 11 00 11111111111...........2112222122200000000000 1011111111111.............11921021201330090000000000 1.10 11111011111111..............0110194114132100000800000000 11 .. 11 00 1.20 111111111111111...............321122212221122000000000000000 111011111111............191221203110090000000000 458 Day 46 1111 .... 3211 0000 111 ...114 000 1111111101111.............12121190014110000008000000 1111111.......22122120000000 11101111111111111.................1219021230131122200900000000000000 1.10 DuPont-4739 Day 47 111111 ...... 111132 000000 111111111101............211100194411000000080000 111111......221122000000 1.10 11101111111111111111....................1192210213301122122200900000000000000000 Sanitized. Doesnotcontain TSCC H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________ Day 48 Day 49 Female, II - 0 mg/kg/day 666666644444441111111232222398484593493470 666666666666666664444444444444444411111111111111111333333322332323227352128494333408412880451456750985 666666666666666644444444444444441111111111111111222233433233332358985206044081583149953169689758 666664444411111334238630634106 11111111 ......., 14231121 00000000 11.. 41 00 11111111111111111111111111..........................3024332112311222222011101100000000000000000000000000 11111111........2212121100000000 1.20 111111111111111111111111111111111111111111111.............................................122212214113023223212311222011210111142413112000000000000000000000000000000000000000000000 INDIVIDUAL DOSE VOLUMES (m L ) FOR FEMALE RATS Day 50 Day 51 Day 52 Day 53 Day 54 1.10 1.10 111... 321 000 111... 321 000 1.10 1.10 11.. 11 00 11.. 42 00 11..2400 111 ... 114 000 11.. 10 00 11 .. 01 00 1111111111..........22221122110000000000 111111111111............412133013232000000000000 11111111 ........ 01011411 00000000 1111111111111111................21132322232221110000000000000000 11111.....1402300000 1111 .... 1212 0000 11 .. 22 00 11.. 12 00 1.20 11 .. 21 00 1.10 111 ... 212 000 ' 1.20 1111111111111111................01011112431114210000000000000000 111111111 ......... 222212211 000000000 11111111111111111111....................1222211210242113333200000000000000000000 11111 .....13211 00000 1.10 11111111111111111111111.......................3232222211122014111014200000000000000000000000 111111 ...... 021133 000000 1111111111..........21122124120000000000 11111 ..... 21132 00000 1.10 1111111111111111111111111.........................12323322222212141110142110000000000000000000000000 11111111111111..............2122212141330200000000000000 459 Day 55 11111..... 13211 00000 1111111111111.............20111411101420000000000000 111111111111111111..................430221132323222112000000000000000000 111111111 ......... 212121212 000000000 DuPont-4739 Day 56 1111 .... 1322 0000 11 ..21 00 1111111111 .......... 1121142152 0000000000 11 .. 32 00 1.30 11111111111111111111111111..........................1221212422122233132323211300000000000000000000000000 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________ _____________ DuPont-4739 Day 57 Day 58 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 59 Day 60 Day 61 Day 62 Day 63 Day 64 Day 65 Female, II - 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0 mg/kg/day 666664444411111232235849873404 641293 666666666666666666666666666666666666644444444444444444444444444444444444441111111111111111111111111111111111111222332332333323323243332333232323323344430838427108943155328604452808598639505952914173845605878816963538994141 664411420606 1111....24320000 1.20 1.20 11 .. 53 00 1111.... 5222 0000 111 ... 122 000 11111111 ........ 21312333 00000000 11 .. 22 00 1111 .... 3234 0000 111111......233113000000 . 11111111 ........ 42313123 00000000 11 .. 12 00 111111 ...... 243222 000000 11.. 53 00 1111 .... 5222 0000 111 ... 122 000 1.10 111... 233 000 11.. 12 00 1111 .... 2332 0000 11..2300 1.30 1111111 ....... 4123313 0000000 111111......234131000000 11 .. 32 00 11 .. 21 00 111111......243222000000 111111111111111111111111111111111111111.......................................535222123232211332232324112331342313132000000000000000000000000000000000000000 11111.....2432200000 11111111111...........2535222122100000000000 11 .. 23 00 111111111.........312332232000000000 111111111111111111 .................. 341231122334233131 000000000000000000 111111 ...... 232532 000000 111111111.........535212123000000000 1111111111..........42322322330000000000 111111111111111...............253232535212123000000000000000 1111111111 .......... 4232323223 0000000000 111111111111111...............253232535212123000000000000000 111111...... 253232 000000 111111111 ......... 553212123 000000000 11 .. 42 00 111111 ...... 323232 000000 11..3200 ' 1111111111 .......... 4232323223 0000000000 111111...... 253232 000000 111111111.........522531123000000000 111111 ...... 242323 000000 11 .. 32 00 11 .. 23 00 Does notcontain TSCACB 461 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 75 Day 76 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 77 Day 78 Day 79 Day 80 Day 81 Day 82 Day 83 Female, II - 0 mg/kg/day ! 666666666666666664444444444444444411111111111111111223322322233222238494398444430859851456334950598704 1111 .... 2523 0000 11111111111...........2122535133200000000000 111111111111111 ............... 232121235323552 000000000000000 111111111111111...............522212322532532000000000000000 111111111111111...............135222352225223000000000000000 111111 ...... 322225 000000 111111111 ......... 235352212 000000000 1111....23250000 11111111111 ...........222132535220000000000Q 111111111111111...............212352232225325000000000000000 1111 .... 5322 0000 11 .. 22 00 111111111.........352123225000000000 1111 .... 2325 0000 11111111111 ........... 23225352212 00000000000 666666444444111111333333372321214780 664411335889 664411321575 666644441111432306083168 664411334496 664411238098 666666666644444444441111111111334223322383065528963106395144 1111111111 .......... 2233234232 0000000000 1111111111..........23232234230000000000 111111111.........233252233000000000 1.30 11 .. 52 00 1111111.......32232330000000 1.30 1111111111..........32233352320000000000 1111111111..........33232322350000000000 1111111111..........23323523230000000000 1111111111..........32233352320000000000 11111111........3332325200000000 11 .. 32 00 Doesnotcontain tsca CRI 462 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 Day 84 Day 85 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 86 Day 87 Day 88 Day 89 Day 90 Day 9: Female, II - 0 mg/kg/day ir 641257 666666666666666666666666644444444444444444444444441111111111111111111111111333333232333223223323322218375231042844384939848497921846095885055147334490 111111111111111 ............... 322023353526432 000000000000000 111111111111111...............220233535322364000000000000000 111111111111111...............220235335362243000000000000000 111111111111111...............322023523533264000000000000000 111111 ...... 343226 000000 111111111 ......... 023532235 000000000 11111 ..... 63224 00000 1111111111 .......... 3023352235 0000000000 111111111111111...............202353233256432000000000000000 11111111........3632236400000000 11 .. 53 00 666666666666666666644444444444444444441111111111111111111234332223423323333268063528906550440886304135143195696898 1111111111 .......... 3233235332 0000000000 1111111111..........23332332350000000000 1111111111..........23333232350000000000 1111111111..........23333232350000000000 1111111111 .......... 3323223533 0000000000 1111111111..........32332353320000000000 1111111111..........33533232320000000000 TSCA CBS 463 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 0 Day 1 Female, IV - 50 mg/kg/day 666666666666666666666666666444444444444444444444444444111111111111111111111111111333323333332323232323222333963561116294419679075757571696502311110798387441286065 664411228361 666666444444111111333333723614338588 00000000000000..............0000000000000043434443444443 00000.....0000034444 0000000000000000 ................ 0000000000000000 3334444444444444 0.04 000 ... 000 334 0000 .... 0000 4444 00000000........0000000044433344 00000.....0000044444 000000......000000344444 0.04 0.03 000 ... 000 344 0.04 0.04 0.04 INDIVIDUAL DOSE VOLUMES (itlL) FOR FEMALE RATS Day 2 Day 3 Day 4 Day 5 Day 6 0000000000000000................00000000000000004334434444444334 0000000000000000000...................00000000000000000004444434433444444444 0000 .... 0000 4334 0000000000..........00000000004443344444 000000000000000000000.....................000000000000000000000344334444444434444444 0000000000000000000000000000............................00000000000000000000000000003443444443433444444434444444 0000000.......00000003344444 00000000000000000000000000000000000...................................0000000000000000000000000000000000034344443334444443344443444444444444 00000000000000000000000000000000000...................................0000000000000000000000000000000000034344444343344444444434433444444444 Day 7 00000000000000000000000000000000000...................................0000000000000000000000000000000000044444444544444444454444445444444445 DuPont-4739 Day ( 00000000........0000000044444444 000000000000000000000000000...........................000000000000000000000000000544444444545444444444444454 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 9 Day 10 Female, IV - 50 mg/kg/day 666666666666666666644444444444444444441111111111111111111223333323333323233369062441791119563963741107981231850669 666666666666666644444444444444441111111111111111332333233332232227184673135575773356856881086124 0000000000000000000000000.........................00000000000000000000000004544444444444444444454444 00 ..00 44 00 .. 00 45 00 .. 00 44 00 .. 00 44 00 .. 00 54 00000.....0000044444 0.04 0.04 0.04 0000000000..........00000000004444444445 0.04 000000 ...... 000000 454444 0000....00004544 0000....00004444 00 .. 00 54 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 11 Day 12 Day 13 Day 14 Day 15 0000000000000000000000000000000000..................................00000000000000000000000000000000005454444444454444444444444444544444 0.04 00000.....0000044444 00000000000000..............0000000000000044444444444544 0000000000000000................00000000000000004455445444444444 000000......000000444444 000000000000000000000000000...........................000000000000000000000000000444445454444444444444444544 00..0045 00000000........0000000044555444 000000000000000000000000000...........................000000000000000000000000000555545444445544555444454554 0000....00005444 00 .. 00 45 0.04 0000000000000000000000000000............................00000000000000000000000000005545445545544454544545554445 Day 16 00000000........0000000054544454 0000000000000000000000000.........................00000000000000000000000005544454444555445455455444 00 .. 00 55 DuPont-4739 Day 17 0000000000000000000000000.........................00000000000000000000000004544555455544444545454544 00 .. 00 44 00 .. 00 54 000000......000000555445 'WSmIBre.t Dom nctamBln 465 H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 18 Day 19 Female, IV - 50 mg/kg/day 666666666666666666666664444444444444444444444411111111111111111111111333333333323222323223321161629935644991607775532911116650077893442818 666666666666444444444444111111111111233322333333727571836431336065615888 0000000000..........00000000004454455455 0000000000000000000000000.........................00000000000000000000000004444455545445545445444555 0000 .... 0000 4454 00000000........0000000045555444 00 .. 00 44 0.04 0000 .... 0000 5554 000000......000000544554 00..0044 00 .. 00 54 000000 ...... 000000 445555 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 20 Day 21 Day 22 Day 23 Day 24 00000000000000..............0000000000000044545455544444 00000000000...........0000000000045455544545 0000000000..........00000000004454554455 00000000000000..............0000000000000054555455554555 00 .. 00 55 0000000000000000000 ................... 0000000000000000000 5555555565555555654 0000000000000000000000000.........................00000000000000000000000005545545555555555545555565 0000000000 .......... 0000000000 5555455565 000000 ...... 000000 545554 0000000000000000000...................00000000000000000005555554555555555565 0.05 000000000 ......... 000000000 554555655 0000 .... 0000 5455 0000000000000000000000000000000...............................00000000000000000000000000000005455555555545555555565555545565 Day 25 0000000000000000000000000.........................00000000000000000000000005455545555554555555555556 0000000000 .......... 0000000000 5555545565 DuPont-4739 Day 26 0000000 ....... 0000000 5455455 000000 ...... 000000 555554 0000000000000000000000......................00000000000000000000005555555556556555554555 466 Si m' I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_________________________________ ___ DuPont-4739 Day 27 Day 28 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 29 Day 30 Day 31 Day 32 Day 33 Day 34 Day 35 Female, IV - 50 mg/kg/day ! 666644441111333396356965 641260 666666666666644444444444441111111111111332333323233211616299441793132111807987 666666666666666664444444444444444411111111111111111323233322333323237783625753415771036615386088512484 0000 .... 0000 5545 0.05 000000000000000000000000000000..............................000000000000000000000000000000565555555565554554555555555545 0000 .... 0000 5555 0.05 0.05 0.05 00000 ..... 00000 56655 0000 .... 0000 5556 00000.....0000055655 00000000........0000000056556565 00000.....0000066755 0.05 00000.....0000055555 0.05 0000....00005656 00000000 ........ 00000000 55555656 00000000000000000.................0000000000000000056675565555566555 0000....00005555 0.05 0.05 00000000000000000000000000000.............................0000000000000000000000000000055566755555556656566555555656 00000 ..... 00000 55555 0.05 00000000000000000000000000000.............................0000000000000000000000000000056756555655566655555565555656 00000 ..... 00000 55555 0.05 000000000000000000..................000000000000000000655556656655555565 00000000000...........0000000000055565556765 000000 ...... 000000 555555 00000000000000000000000000000.............................0000000000000000000000000000056755566555655655665566555555 000000 ...... 000000 555555 00000000000000000000000000000.............................0000000000000000000000000000066755556655565555665556565555 000000 ...... 000000 555555 00000000000000000000000000000.............................0000000000000000000000000000056655665567656765555565665565 Doesnotcontain 467 -ti-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 36 Day 37 INDIVIDUAL DOSE VOLUMES (mL ) Day 38 Day 39 Day 40 Female, IV - 50 mg/kg/day i 641396 666666666666666666666666666666666644444444444444444444444444444444441111111111111111111111111111111111332333323332333333332322232232332376362139251831761194416774955670753311536810568869211079326878508441 0000000000000000000000000.........................00000000000000000000000007556555565555565655565665 00 .. 00 56 00000000........0000000065566675 000000......000000555555 00000000000000000000000000000.............................0000000000000000000000000000065556655566765575655655665566 0.05 0000000000000000000000000000000000..................................00000000000000000000000000000000006665555556655567665575555655555666 0.05 0000000000000000000000000000000000..................................00000000000000000000000000000000005556676576555555665555665555566656 00000000000000000000000000000000000...................................0000000000000000000.000000000000000065565555657657656655655555556566565 Does not contain TSCA CBI 468 FOR FEMALE RATS Day 41 Day 42 000000000000000000..................000000000000000000555555555655556565 0.06 . 000 ... 000 565 00000000........0000000065665665 0000 .... 0000 5656 00 .. 00 56 0.06 0.06 00..0056 00..0056 0000....00005567 0000....00005675 0.05 0.05 000000000.........000000000567665566 00000.....0000056656 00 .. 00 66 00 .. 00 76 Day 43 0000000000000000000000000000000...............................00000000000000000000000000000005555566656667665655656566556566 0000....00006667 DuPont-4739 Day 44 000000 ...... 000000 565656 0000000000 .......... 0000000000 6665655656 0000000000000.............00000000000007565656566566 000000 ...... 000000 566567 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________________________ Day 45 Day 46 Female, IV - 50 mg/kg/day 666666444444111111333332963516696520 666666666666666666666666666664444444444444444444444444444411111111111111111111111111111333233323223232323323223333331619294416379075771875753162431181107931874412656386088538 0000 .... 0505 6600 0.06 " 0.05 0.06 00000 ..... 00000 66655 0000 .... 0000 5656 000 ... 000 566 0.06 000000000.........000000000555675666 00 .. 00 55 0000....00006676 0.06 000...000655 0.06 0.05 0.06 00000 ..... 00000 66655 0000....00005566 000 ... 000 566 0000 .... 0000 6556 00 .. 00 75 00..0065 000000 ...... 000000 665566 00 .. 00 76 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 47 Day 48 Day 49 Day 50 Day 51 00000000000000000000000000000000000........................,..........0000000000000000000000000000000000066656666555556565666556756665556676 000000......000000666555 00000000000000000000000000000.............................0000000000000000000000000000066665556565665656755666556676 0000....00006655 0000000000000000000000000000000...............................00000000000000000000000000000006666566556556666556756666566676 0000....00006655 0000....00006655 00..0056 00..0056 00000000000000000000000.......................0000000000000000000000066666556565665656756666 0.06 00000000........0000000066665556 00 .. 00 65 0000 .... 0000 6665 000 ... 000 567 00000.....0000065666 000000......000000756666 000000......000000566676 Day 52 0000....00006655 0000000000000000000000000000000...............................00000000000000000000000000000006566666556565666556756666566676 DuPont-4739 Day 53 000000000000000000..................000000000000000000666566666555656556 00000000000000000.................0000000000000000055666567665666676 8> Sa mues *Animal was misdosedwith0.50 mLs testsubstance. 469 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 54 Day 55 INDIVIDUAL DOSE VOLUMES (itlL) FOR FEMALE RATS Day 56 Day 57 Day 58 Day 59 Day 60 Day 61 Day 62 Female, IV - 50 mg/kg/day f 666644441111333396356965 666666666666666666666666666666644444444444444444444444444444441111111111111111111111111111111322333333322322333333233323222327833641717755756162901144196793361858568260841311114230797088 0000 .... 0000 6565 0.06 0.05 0000 .... 0000 6666 000000 ...... 000000 655566 000 ... 000 656 000000......000000556756 0000000000..........00000000006676666566 . 00000000 ........ 00000000 65656566 0.06 0000000.......00000005665566 00000000........0000000075665656 0.05 00 .. 00 66 00..00 66 ' ' 000 ... 000 566 000 ... 000 766 00000.....0000066565 000000000000000000000000000000..............................000000000000000000000000000000765666766666666656565676666666 0000000000000000000000000000000000..................................00000000000000000000000000000000007665666666766566666665667556656666 0.06 0000000000000000................00000000000000006765666666666565 000000000.........000000000665667566 0000000000..........00000000006667566666 000000 ...... 000000 566656 0000000000..........00000000007666656666 0000000.......00000006655666 00000 ..... 00000 66666 0000 .... 0000 5676 000...000566 000...000566 000000......000000667656 00000 ..... 00000 65667 0.06 0000000000..........00000000007666566666 0000000000..........00000000007666566666 0000....00006556 0.06 0.06 000000......000000666666 0000 .... 0000 5667 00..0056 0.06 000000......000000666675 ' 00 .. 00 66 0000 .... 0000 6665 000...000766 0.06 0000000000000000................00000000000000006567666666666565 0000000000000000000...................00000000000000000006766566666656675666 Sees notcontatnTSCACBt 470 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 63 Day 64 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 65 Day 66 Day 67 Day 68 Day 69 Day 70 Day 71 Female, IV - 50 mg/kg/day 3@ g 3 ft 3 8 1I 666444111333963696 664411236505 666666666666666666666666666644444444444444444444444444441111111111111111111111111111333233332323232332322232333311196244196795771807575373613218110791387126564486013858 664411334283 00000 ..... 00000 56666 0.06 0000000000000000000...................00000000000000000006666665667567566766 0.06 0.06 0000000.......00000006668666 . 0.06 0000 .... 0000 5666 00 .. 00 66 0.06 00000.....0000066666 000...000566 0.07 0.05 0.06 0000000 ....... 0000000 6756676 00..0066 . 0000000 ....... 0000000 6666668 0.06 00000000000000000.................0000000000000000066566666666656675 000000000000000000..................000000000000000000675666766666666686 000000000000000000000000000...........................000000000000000000000000000656666666666566756566677666 000000......000000666666 00 .. 00 86 0000000000000000................00000000000000005666666666665667 0000000000000000000...................00000000000000000005676566766666666686 0000000000000000................00000000000000006666566666665667 00000000........0000000056675667 000 ... 000 666 00000000........0000000066666686 0000000000..........00000000006566666666 00 .. 00 66 0000000000000000 ................ 0000000000000000 5676566756676666 0000000.......00000006666686 000000000000000...............000000000000000656666676666666 000000000000000...............000000000000000656666667666666 1 SS CB! 471 I ! 3i 3-5b H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations J Day 72 Day 73 Female, IV - 50 mg/kg/day 666664444411111333326359696560 666666666644444444441111111111333233332361119441921231107981 666644441111223369073748 666666666666664444444444444411111111111111333223322323237618331777755535561882664180 664411332438 000000000000000 ............... 000000000000000 656666667666666 000000 ...... 000000 656666 00 .. 00 66 0000000 ....... 0000000 7666666 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 74 Day 75 Day 76 Day 77 Day 78 0000 .... 0000 5666 00000000000 ........... 00000000000 66667666666 00000 ..... 00000 56666 0000000000..........00000000006666666676 000000000000000 ............... 000000000000000 656666667666666 000000000000000...............000000000000000667667776665666 000000000000000 ............... 000000000000000 656676677766666 Day 79 000000000000000...............000000000000000666765676776666 DuPont-4739 Day 80 0000000 ....... 0000000 6766566 00000000 ........ 00000000 77766666 ni 472 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 Day 81 Day 82 Female, IV - 50 mg/kg/day 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111333333223332222233233333323332333232764718331575769057271694411199656333586561888602374141831107921869506 000000000000000...............000000000000000666777666666567 000000000000000 ............... 000000000000000 666666766777665 INDIVIDUAL DOSE VOLUMES (inL) FOR FEMALE RATS Day 83 Day 84 Day 85 Day 86 Day 87 000000000000000...............000000000000000677666666676675 000000000000000...............000000000000000666776667665667 00000.....0000075666 0000000000 .......... 0000000000 6666667776 0000000000..........00000000007776566766 00000.....0000066666 00000 ..... 00000 56667 000000000.........000000000666667776 0.06 Day 88 00 .. 00 65 0000000000000.............00000000000007666666766776 Day 89 00 .. 00 65 0000000000000.............00000000000006667766766766 Does notcontain TSCAc$i 473 ISO Ujejiibo |ou H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________ Day 90 Day 91 Female, IV - 50 mg/kg/day 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111332323232333333333333222332332323231993661627948235117136775677554419036119021133806651965832605841887874 000000000000000...............000000000000000656676677766666 0000000000..........00000000006666666777 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS 474 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 0 Day 1 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Day Female, VI - 250 mg/kg/day s CO g g 666666666666666666444444444444444444111111111111111111322333222233232332959068356467608777812232229425250921 666666666666666664444444444444444411111111111111111333333223233223320316343323983368739674735832198067 0000 .... 2111 0978 00 .. 21 09 0.19 0.18 00 .. 22 22 000000 ...... 112111 970698 00000 ..... 21112 08880 000 ... 211 188 00000.....2221100089 000...122800 00 .. 12 91 0.20 0.20 000...111789 00 .. 21 90 0.19 00000.....2211122798 000000000.........111221112980088680 0000000.......22112110088189 . 00000 ..... 12122 90800 00.. 22 10 00000000000000000000000000000000000...................................2222121122121112211121211112211211110009001890879800888099229908887086 000000000000000000000000000000000.................................122122112112211111122111121112221900080088189097698800897099220888 00 .. 22 10 00000000000000000000000000000000000...................................1222222211112112112111211221121112109001800018890889088089709922970868 000000......211211097098 0000000000 .......... 1221211111 9229086987 0000000000000000000...................21222122221122111110910080001890088888 00000000000000000000 .................... 22121112112211211111 00089709822970869889 000000000000............212222112111008000198888 000 ... 212 109 000000......122222390221 00000000000000000000000000000.............................2222222222222222212222222121131223231022330210093596000908 000000000000000000..................222212222222212121232590230100609098 00 .. 22 31 000000000000000...............222222222222122323132222130090 3O 1 > a SLr 475 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 9 Day 10 Female, VI - 250 mg/kg/day 666664444411111322239596781299 666666666666666666666666666666444444444444444444444444444444111111111111111111111111111111333233223232223223323322333333067468633077858739336832346031235422223521026752380198477396 0000....21222390 0.22 0.21 0.20 00000 ..... 22221 05609 00000000000...........2212212222130903218009 0.23 000 ... 222 022 000000......222222323211 . 00 .. 22 32 0000....21222930 0.22 0.21 0.20 0000 .... 2222 0560 000 ... 122 390 0000000000 .......... 1122222212 2338901009 0.20 000...222222 0000000 ....... 2222222 3123132 INDIVIDUAL DOSE VOLUMES (mL ) FOR FEMALE RATS Day 11 Day 12 Day 13 Day 14 Day 15 0000 .... 2122 2390 000000000000000000000.....................222222212221122222122210056309039218000930 0000000000..........22222222222223331212 00000 ..... 21222 23902 0.21 00000000000000000000000000000.............................2222212212221222122222222222200560339090231009823022233112 00000 ..... 21222 29302 0000000000000.............22222212211221005603908902 00000000000000000.................2222122222222222231009302223123312 00000.....2222251515 0.23 0000000000000.............22222222222222267225502244 000000 ...... 222122 522951 0000000000..........22222222225545332556 00000000000000000000000000000000000...................................2222222222222222222222122222222222251531522672255202445229515545332556 Day 16 000000000000000...............222222222222222351515226722550 0000 .... 2222 2424 0000000000000000................22212222222222225229515335452556 DuPont-4739 Day 17 000000 ...... 222222 515153 00000000000000000000000000000.............................2222222222222222122222222222222672255202445229515545255336 Does notcontain TSACBI 476 I.Does notcontain TSCA OR! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 18 Day 19 Female, VI - 250 mg/kg/day 666444111232995281 666666666666666666666444444444444444444444-111111111111111111111222332332222333223233376705877834678630396379922621084252225523 641360 666666666644444444441111111111333332333203318334623396194778 0000 .... 2222 5151 0.25 000...222322 000000000 ......... 222222222 222672550 00000000........2221222252295144 0.25 0.25 0000000.......22222224555362 ' 0.23 0000000000000000000000000.........................22222222222222222221222223255151522725024422951265 0000000000..........22222222225323555456 INDIVIDUAL DOSE VOLUMES (itlL) FOR FEMALE RATS Day 20 0000 .... 2222 5151 0.25 00 .. 22 32 00000 ..... 22222 26722 0000 .... 2222 5502 -00000000 ........ 22222221 24452259 0.21 0.25 0.25 0.24 00000 ..... 22222 52553 0.26 0.23 477 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________ DuPont-4739 Day 21 Day 22 Female, VI - 250 mg/kg/day 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111333332332322232332232333322223323236833007396596746863733159078323687431333255201299422222996285108847677 0000000000000000000000000000000...............................22222222222222222322222222222224127733478792744805493574741568 00 .. 22 84 00 .. 22 68 00000000 ........ 22222222 33277944 000000000000000000000000000...........................222222222222222232222222222417277747863488488054941565 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 23 Day 24 Day 25 Day 26 Day 27 000000......222222347927 000000......222222327974 000000......222222379274 000000......222222927437 000000......222222327974 00 .. 22 34 00000000000 ........... 22232222222 03556854941 0000000000000 ............. 2322222222222 3305495648415 000000000000 ............ 222322222222 334805494156 0.25 00000000........2232222238054944 000000......222322384054 00 .. 22 49 0.21 0.21 000...222356 000...222356 0.25 0.25 000000......222222844172 000000......222222284417 000000......222222472184 000000......222222484172 000000......222222412478 0000000000 .......... 2222222222 7787478468 000000000 ......... 222222222 787747848 0.26 000000000.........222222222777874848 0.26 0000000000 .......... 2222222222 7877478486 0000000000 .......... 2222222222 7777684848 Day 28 00100 .....2222193858 " 0.26 000000......233222512575 00 .. 22 95 0.22 000 ... 222 766 0.26 0000 .... 3222 0762 00 .. 22 94 0000....32221998 0000....32220558 0.30 0.27 Day 29 000000......222222385969 0000000000..........23322222225125526795 00 .. 22 67 00000000000000000 ................. 23222222232223232 60945762819980507 aDue toerror,theanimalwas misdosedwith 1.18 mL; itwas givenadoseof0.29 m L thengivenan additionaldoseof0.89 mL. 478 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations DuPont-4739 Day 30 Day 31 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 32 Day 33 Day 34 Day 35 Day 36 Day 37 Day 38 Female, VI - 250 mg/kg/day I 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111233322233332223323322232332323333325069964678763339607785878303334631212382942529232520521026713389477968 00000000000000000000000000000000000...................................2222222233222222222322222232222233295398655125279566760762948199575800 000000000000000000000000000000000.................................222222223232222222232222223222232953896279525515426760796681995805 00 .. 23 70 0000 .... 2222 3958 00 .. 22 96 000000000.........223322222551257952 000000000000000000 .................. 223232222222222232 760466762989958051 00 .. 32 07 000000000000000...............222222223223222395986552517952 000000000000000000..................223222222223222232660294676578199805 00 .. 32 07 000000......222222953896 0000000000000000000...................32232222222223222225515762679256076294 00 .. 23 81 00 .. 22 99 000000......232232505807 00000.....3232206149 000000000000000000000000000000..............................222332232222223222323333223222366525715487971882052069169700 00000 ..... 32322 06149 000000000.........222332232665235715 000000000000000000000.....................232222222323333223222417788982050200691697 000000000000............323222223322061496652357 000000000000 ............ 322222232223 154879712880 000 ... 233 502 00000000........3322322200691697 00000 ..... 32322 06149 0000000.......22332226523657 000000000000............322232222223154718978820 00000000000 ........... 33232233222 02506901697 I' Doesnotcontain TSCACBI 479 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Female, 666644441111223295692198 666666666666666666666666666666644444444444444444444444444444441111111111111111111111111111111333333233332222322233332333222303686339341333265776787670884303301795247638983217256922220425 Day 39 Day 40 250 mg/kg/day 0000000.......32222230496616 0000000000 .......... 2332232222 3525718754 00 .. 22 79 00 .. 32 18 000000000000............322233332232162502006908 00 .. 22 97 00000 ..... 22323 14906 000000000000000000000000000000..............................232232223233322233223222322222970691620502088523971665187754 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 41 Day 42 Day 43 Day 44 Day 45 000000......223232466190 0000000000000000000...................32223332223222222220565231897188257475 0000000000..........23223223337690691200 0000....22237492 0000000000000000000000000000000...............................32323323222323333222332322223221717170340611893187644716598089 0000 .... 2232 9724 0000000000000000000000000000000...............................23332332223233223232332223222327113107940611738708844598167916 0000....23229247 000000000000000000..................322232223322322232389187644791598086 0000000000000.............23323222333337701713146110 00000000000000000000000000000000000...................................2233323332223233322232322233223222273117011718940630817649972484791658 Day 46 0000000 ....... 2223322 2497187 0000000000000000000000000000............................32322323333233222322223233221717340611170389649598084716 DuPont-4739 Day 47 0000 .... 2232 9724 00000000000000000.................3223232323222322238848018776491659 00 .. 22 49 00.. 32 06 0000000000..........33232332333171711701 i ntpanySanitized. Does notcontain TSCACBf 480 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations { Day 48 Day 49 Female, VI - 250 mg/kg/day 666666644444441111111322233295967048129924 666666666666666666664444444444444444444411111111111111111111333322332222322233336678633077858733936832522235210267852301 666666664444444411111111323233330332134639986477 000000000000000000000000000...........................223232223322322232232223233729418764749135980688940361 00000000 ........ 33233232 11701717 0000 .... 3232 0625 0.31 0.28 000000000000............223333222233874502875900 00 .. 23 82 0.30 00 .. 22 58 0000 .... 3233 1716 00000000 ........ 23323332 32702198 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 50 Day 51 Day 52 Day 53 Day 54 000000......323232062518 00000000000000000000000000000.............................2233233223232332232333323323287458027509208085171613227089 0000 .... 3232 0625 000000000000000000000.....................322233233223232332232188745802750098205178 0000000000..........33332332321613702829 00000 ..... 32323 51062 0.28 0.28 00 .. 23 74 00000 ..... 33322 50287 000000 ...... 232332 509028 000...322085 0000 .... 3233 1716 . 000000......323332327108 00 .. 32 29 0000....32320625 00000000000000..............3222332332223318745802798500 00 .. 23 82 000000000000000...............322233333233232085711326170289 000000......323232062518 00000000000000000000000000000.............................2233233322232332232333233323287458020975230808517161722908 Day 55 00000000........3232322206251887 000000000000000000000000000...........................332332232333322232333233232458027509020358817161702829 DuPont-4739 Day 56 00000000000000000000000000000000000...................................3232322233233223333232323233333322307352998137601186633192926166242880 Doesnocontato TSCACEI 481 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 Day 57 Day 58 Female, VI - 250 mg/kg/day . 666666444444111111223332597096129289 666666666666666666666666666664444444444444444444444444444411111111111111111111111111111332332332232233233322233332328339636863773305467083246318713520932222134324255088779667 0000 .... 3232 3075 0.32 0.29 0.29 00000.....3322316886 00 .. 32 37 0.26 0.31 000 ... 323 190 0.32 00 .. 32 19 00000 ..... 23233 26166 00000.....3323333842 00 .. 23 82 0.30 0000000 ....... 3233222 3072995 00000000000...........3333232332231117608668 00000000000000000 ................. 23322323333233233 33921961626824820 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 59 Day 60 Day 61 Day 62 Day 63 00000000000000000000000000000000000...................................3233323223233332333323232322233232323316101929616682423399710807528668 00000000000000000000000000000000000...................................3233223332332323332332332323232223333236176101921916682482007352998668 00000000000000000000000000000000000...................................3223333333222323232223323323332323333196126203162688073529986681701924 00000000000000000000000000000000000...................................2332233322332332232333333223232323333322289961761192196166403268808075 00000000000000000000000000000000000...................................3323233332322332332233333332323322333829331324614719977808702010517928 Day 64 00000 ..... 32323 18472 00000000000000000000....................2323322332322333333351732301997780871001 00000000 ........ 33333322 33362498 00 .. 32 29 Day 65 0000000 ....... 2333232 9121847 0000000000000000................32233323323323333537010977808120 00 .. 23 71 00 .. 33 36 00000000 ........ 23333232 33249298 0MPanySanitized. 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Does no!contain TSCACBI 483 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 75 Day 76 Female, VI - 250 mg/kg/day 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111333233322233322233233223333332232226704609596887633933313363460775872839242381292152352399628047752126780 000000 ...... 323332 392418 000000000.........323323322098892487 000000000000000...............323333223233322392410992888487 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 77 Day 78 Day 79 Day 80 Day 81 000000000000000...............333324322323322341190794845887 000000000000000...............323233324323322384841190794578 000000000000000...............333324322323322341190784894587 0000000000 .......... 3342323323 3108419784 00000 ..... 23322 94587 000000000000000...............323233324333222384841190745987 Day 82 000000000000000...............332332324323322344819079481587 DuPont-4739 Day 83 0000 .... 3232 3848 00000000000...........3332432332241190795748 CompanySanitized. 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Jsmazizr&a^*-.- H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 9 Day 10 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 11 Day 12 Day 13 Day 14 Day 15 Day 16 Day 17 Female, Vili - 1000 mg/kg/day fI 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111333232222333333233223322322332322333223422324888744435556907925606587297213537980974209460257732346626909079478440995647303301586016852 0000 .... 8778 3693 0.89 0.80 0000 .... 8899 0959 00000000 ........ 98878877 30491499 0.82 000000 ...... 978898 181316 0000000.......88988980025150 ' 00 .. 89 84 0.81 0000 .... 8978 7484 00000.....8989823951 0.81 0000 .... 8877 3369 000 ... 888 900 0000 .... 9989 3959 0000000000000000000 ................... 8888989788778978888 3914992186020411501 . 0000 .... 9898 5840 0.81 000000000.........888989879357219448 0.81 00000000........7888788860339099 000000000000000000000.....................998888998788778978988339060599211504149181 . 00 .. 88 20 0.95 000 ... 898 841 0000....98784748 000000......898988131952 000000000000000000000.....................878888999888987787877336900959012139494998 00000000000000..............8888988989988813415002581610 0000000000 .......... 8988988987 3514472198 00000000000000000000000000000000000 ................................... 88898787788888999888877897889898898 31541693900959304149921813160205890 0000000000..........88988989871321954478 100000000100000000010 ..................... 088899889199989888089 330614424907079095900 101101001000000000000000........................909199099008999999888988132010004008188256797785 11100001000000000000000000000000001...................................0199009988888998899998998888999888030027043271670088861449079009598597 1100000100..........91099990983104201005 00110001000000000000000.......................8090899198888899899898832070134400900986147959 00.. 99 88 01010010000001100000....................9190990999888088990913200402105679708570 000000......889889236414 0110000 ....... 9019998 4900707 000000100000 ............ 988989880899 309190950888 00101010000001010000....................9909901999890899880842013002569705107708 'PS Mu**aae^j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 18 Day 19 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 20 Female, VIII - 1000 mg/kg/day Jifif8s 1p?9 gISI1aamm 641299 666444111332728560 641314 641237 664411320709 666666444444111111332233295609709415 666644441111342290763285 _ 666666444444111111433323056042138760 641343 664411225442 666666444444111111322222778394304068 664411234239 666666644444441111111322233388355857246256 664411336969 641377 11010000000000010000000000010000000...................................0808999998889809888199998890999888808730818256797959083700042490709614 0110010000..........99009999181320001450 00000 ..... 98889 34614 0.82 0.84 0.99 1100000 ....... 0199989 0070790 0.90 000 ... 888 995 0010 .... 8908 3810 0.98 000...999852 . 10000.....0898807697 0.97 1000 .... 8908 5108 10101000........0999190901243000 11000000000100000000000.......................0889189889099989988888930813590124907079009446 00 .. 99 88 10110000000101000000....................0910999899809089998801300420519070826757 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 21 Day 22 Female, VIII - 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Doesnotcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 39 Day 40 Female, VIII - 1000 mg/kg/day 666666444444111111223332972183956407 666666666666666664444444444444444411111111111111111323322332234343230792569076905004209079451853231760 666666666666444444444444111111111111332222222233456483749472348240336809 664411338857 666666664444444411111111222333338355569724662697 001100......990199590077 11111111111001101111111111111.............................0223221011099109012111101302000000000000770080000000000000 1111 ....0030 0000 111111 ...... 121020 000000 0001101.......99091905907070 11111111110111001111111111111111111111......................................2232211010910099121110113203100001202000000000007000780000000000000000000000 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 41 Day 42 Day 43 Day 44 Day 45 00011011111111111001110111111111................................9990190223212011099100912111011359700700000000770000008000000000 111...020000 1111111111 .......... 0030120120 0000000000 01 .. 90 90 01 .. 91 90 1.20 0.91 1111111111..........12232120110000000000 100 ... 199 065 11 .. 02 00 11 .. 10 00 1111 .... 2322 0000 11 .. 21 00 1111 .... 1131 0000 11.. 20 00 1.10 111 ... 131 000 1.10 . 1111 .... 3103 0000 1.10 01 .. 90 90 1100 .... 1299 0091 1.10 11111111........2232120100000000 110...119006 0.95 11111111111111..............2010322221113100000000000000 11 .. 20 00 1111111111 .......... 1131131031 0000000000 010110111111111110011111111111111.................................909129122321201119920102322211131909001000000000650000000000000000 11 .. 02 00 1111111111..........11311310310000000000 0110 .... 9019 9090 1.20 0111111111110011111111111111............................91223122011199201023222111311000000000006500000000000000 111111111111............201131131031000000000000 491 Day 46 01110.....9012990009 0111111111110101111111111111111111111111........................................91223212011192901023222111111131032310311000000000006050000000000000000000000000 DuPont-4739 Day 47 0111001111111111101011111111111111111111111...........................................90129912232120111909201232211213120113113109000190000000005000060000000000000000000000 11 .. 31 00 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 Day 48 Day 49 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 50 Day 51 Day 52 Day 53 Day 54 Day 55 Day 56 Female, VIII - 1000 mg/kg/day 2 666666666666666666666666666666666444444444444444444444444444444444111111111111111111111111111111111222222332323433343223232323222333748394745542006902560693079797281332406804360178327941557090895604 666666666666444444444444111111111111333322332332975635584288972646653972 010...099099 011...900600 1.10 1.10 1111011111..........22091223120001000000 1011111111..........22913243310070000000 11100.....9911165000 11111.....0101100000 11..0200 . 11 ..20 00 111111111111............131032221112000000000000 111111111111............423112211213000000000000 1.20 1.20 1.00 1.00 1.10 1.10 111...113000 111...141000 1111....01310000 1111....31110000 1.30 1.30 1.10 1.10 01111 ..... 90012 60000 1111111111111111111111111111111111111101........................................13111411322014223111301120021323111341920000000000000000000000000000000000700000 101 ... 090 060 110 ... 129 700 1111111111111....:........10014321113230000000000000 11111111111111111111111111..........................3111131410142232311112201200000000000000000000000000 110 ... 009 006 110 ... 912 700 1111111111111111111111111.........................31112132012200143231111320000000000000000000000000 11 .. 24 00 11 .. 02 00 1111111111..........11131131140000000000 1111111111111111111111111111111111111110110...........................................11113014214213223111212000114323111023290190000000000000000000000000000000000070000600 11..1300 1110....00190006 0111....90016000 10..2907 10..2907 11111111111111111.................1201002131132432100000000000000000 111111111111............013211331124000000000000 11111.....1201000000 1.20 1.20 111111111111............202214132231000000000000 111111111.........311321114000000000 11111111........4211213300000000 111 ... 022 000 111111111.........311311411000000000 1.10 111111111111111011111111101111..............................212223331110021913242231290023000000000000000940000000000000 11 .. 13 00 1111111111111.............12131133021220000000000000 Does notcontain TSCfi 492 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________________ DuPont-4739 Day 57 Day 58 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 59 Day 60 Day 61 Day 62 Day 63 Day 64 Day 65 Female, VIII - 1000 mg/kg/day a trms 666666666666666666666666666644444444444444444444444444441111111111111111111111111111332243322322342323322223333354480065425690307926797281093324178460953270907489560415 666666666666666664444444444444444411111111111111111333323233332222227956455728883739479263660957243068 0.99 111 ... 020 000 1110 .... 1339 0004 11 .. 24 00 111111 ...... 222123 000000 111 ... 100 000 11111111........2311123300000000 1.20 111111......223211000000 . 1.00 111111111.........213131213000000000 1.10 1110 .... 0029 9000 10.. 39 04 1111 .... 3412 0000 111111111111111111..................233211120031231222000000000000000000 . 111 ... 211 000 11 .. 32 00 11 .. 20 00 111111 ...... 113213 000000 1111 .... 3211 0000 111101111110 ............ 002391324229 000004000009 111111111111111111111111111111111.................................311232213112013223213311121210023000000000000000000000000000000000 111111111111111111111111111111111110111101111.............................................312113120213132122231233111002222319002391324000000000000000000000000000000000009000040000 111111111111111111111111111111101111111111110.............................................311213321122021331223311120221090232422310139000000000000000000000000000900000000000004000 111100......030299000049 111111 ...... 124232 000000 111111111111111111111111111111111.................................311321122131320221231311210031232000000000000000000000000000000000 111111 ...... 003012 000000 111111......235333000000 111111111111111111111111111111111.................................232214231224214113232124031214112000000000000000000000000000000000 1111111111..........00123023350000000000 1111111111..........51023002330000000000 11..3300 11..3300 1111....41210000 1111.... 4112 0000 111...210000 111...210000 11..3100 11.. 31 00 111111......232412000000 111111......423212000000 1.30 1.30 11111.....1411200000 11111.....4112100000 11..1300 11..3100 11 .. 22 00 11111111........3222442100000000 1.20 ' 111111......421242000000 111 ... 322 000 Does no!contain 493 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Day 66 Day 67 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 68 Day 69 Day 70 Day 71 Day 72 Day 73 Day 74 Female, VIII - 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1000 mg/kg/day 666664444411111223339728195604 666664444411111232333079270907 664411225694 666666666666666666666666666666666444444444444444444444444444444444111111111111111111111111111111111343233333332224332222233322223233904485697578350976400654834722985323352697332461585617842408090676 111111111111111 ............... 011330254333322 000000000000000 1111111111 .......... 2422252252 0000000000 111111111111111...............011330243523233000000000000000 11111 .....22522 00000 11111 ..... 22452 00000 INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 77 Day 78 Day 79 Day 80 Day 81 11111 ..... 01312 00000 1111111 ....... 0353633 0000000 111...322000 111111111111111...............011230353633322000000000000000 111111111111111 ............... 011230336533322 000000000000000 111111111111111...............011320533633223000000000000000 111111 ...... 011230 000000 111111111 ......... 353633322 000000000 1111111111..........22252242250000000000 1111111111..........52422252220000000000 11111 ..... 22522 00000 11111 ..... 42522 00000 11111 ..... 22252 00000 11111 ..... 52242 00000 1111111111..........22525242220000000000 495 Day 82 111111111111111...............011230353363322000000000000000 1111111111 .......... 2252225224 0000000000 DuPont-4739 Day 83 111111 ...... 301120 000000 111111111 ......... 353633322 000000000 1111111111 .......... 4222522522 0000000000 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Day 84 Day 85 Female, VIII - 1000 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111323333332322323232332222332323242233323342322435697406588557754287939498130725082960904276342697378472660532953306890470979146041526085 111111111111111...............311140253633422000000000000000 111111111 ......... 342252252 000000000 1.20 111111111111111...............302111364533422000000000000000 1.20 111111111 .........222252345000000000 . INDIVIDUAL DOSE VOLUMES (mL) FOR FEMALE RATS Day 86 Day 87 Day 88 Day 89 Day 90 111111111111111...............102561134333422000000000000000 111111111111111...............113426105333422000000000000000 111111111111111...............113405123633224000000000000000 111111111111111...............113402536331422000000000000000 111111111111111...............302361114533422000000000000000 1111111111..........25234222250000000000 1111111111..........25342252220000000000 1111111111..........32242252250000000000 1111111111..........22322252540000000000 1111111111..........22522523420000000000 Day 91 1111111111 .......... 3123054611 0000000000 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX B INDIVIDUAL BODY WEIGHTS 497 CompanySanitized. Doesnotcontain TSCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Critical Dates INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES Day 69 Male and female rats designated for reproduction evaluations were co-housed. Body weights that were collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 91 Fasted final body weights of male 90-day exposure rats scheduled for sacrifice. Day 92 Fasted final body weights of female exposure rats scheduled for sacrifice. Days 122 and 123 Fasted final body weights for male and female one-month recovery rats scheduled for sacrifice, respectively. Day 182 Fasted final body weights for male and female 3-month recovery rats scheduled for sacrifice. 498 CemparsySanitized. Does notcontainTSCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __________________________________________________________ DuPont-4739 Day 0 Male, I - 0 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111101121001011011101011011111200212010121201112856210585806747072536808740960501779115261042395351344558204795250866576464804028475295490 222222222222.444644673455089677411145............322945898418 222222256862539187242.......5598574 232.8 2222 6374 6188 .... 3685 224731 ..41 225721 ..56 222225945480690.....55000 222 464 235 ... 395 249.2 222 548 098 ... 389 237.2 23 40 20 .. 85 22 56 30 .. 40 Day 7 223338901151798 .....45765 23233323233 72903272715 48312032317 ........... 42924955649 232322323373919947028858613564..........3217456346 322232333223322333309995904199159910203688002794228243637...................5509674263067323117 INDIVIDUAL BODY WEIGHTS (g) OF MALE RATS Day 14 Day 21 Day 28 Day 35 Day 42 333333333333343333333343333333333333334333333343583846425314541864205525367376118051722584873481901838770117974211873031388832202163866.............................................336939387169922772099980746331542165219066756 334346826338253.....47799 443334344334333616952900545497827123983161101...............427939124547558 333343443433343334333433397682810836866798598558961922467011605744442968263.........................2373592977488328650168098 33444 99367 88065 ..... 37988 465.3 444444444444444354454435444344444433561712062041021280221037003078243545718242830803571683534444696532910341460.....................................3372810193881317263481155903052111608 44 31 88 .. 38 444541591186306.....08519 444444444335355726916678828461941178238971..............92754062210674 444454444455235440155132872388060111............472712226984 444444445436284275058764697820..........2124998785 4444 5657 0817 .... 0915 444554382425443.....35160 445391565...397 ' 544401092266....7607 454 660 298 ... 950 445 948 990 ... 713 44 83 80 .. 29 444455725477198286......335369 444454577772318.....55768 444444964874716351......281496 4454 8826 1517 .... 6515 444479696845....4929 Day 49 446.1 4455 6935 2431 .... 0766 454545544554444454445646444454554555456928274057012996689947040612926013001381211033783816920996811194607688345855313.......................................083986334758216351250261323680067144628 492.4 Day 56 449.7 4555 7167 0371 .... 3974 454444456555565736533403534334555994614421561...............598350896864774 555554554455554545455566521315861874033817169102322590367103425712710323927.........................2328275339291613704915579 " npan,rSanfifeed. Does notcontain tsca fi 499 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL BODY WEIGHTS (g) OF MALE RATS CompanySanitized. Poesnotconfate TStfAMill Day 63 Male, I - 0 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111100112201120021122011000110111011111111010121796452161072409110720758250680757058438580166246952495400768474957233380086524196054455558 447855 ..65 533.4 569.8 589.9 4555 7652 3922 .... 0568 54 53 95 .. 24 446446456555 420985814654 744510992501 ............ 322414617081 445655456782212923093660038.........390477508 45 75 29 ..1 555555555555822731132588786661826...........69897996940 Day 69 465556554456556555595704705893423500360278208127943642659...................3335686773326280417 530.9 Day 70 44 99 57 .. 56 4556556 8491870 0499542 ....... 7279496 544456854623368048......354569 555555555623574945703284015473..........0409720042 Day 77 455566655644566710713008165416418432508956516...............327363336728748 556555565558146852385299933280..........3536247005 Day 84 5456 2973 1382 .... 3508 656.1 5644466665 0055813176 0821437930 .......... 3088187596 5555665556 9674036692 4458335591 .......... 3624478512 Day 90 5556 3173 2452 .... 5218 665666610052239549......744082 Day 91 556556052801969702......100744 456444665983739036106665882.........393888405 5666556565 6215570728 1110575533 .......... 6436280480 Day 99 445567305561171.....96254 5666556565 2514770728 7468579451 .......... 3720046318 Day 106 44655 82406 94864 ..... 04166 555656566699929353148160127138..........3642623644 500 CompanySanitized. Doesno!containTSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________ INDIVIDUAL BODY WEIGHTS (g) OF MALE RATS Day 112 Male, I - 0 mg/kg/day 666666666666666666666666644444444444444444444444441111111111111111111111111111010120010121122100221180067770965912011046721458600592646885044747902495 666666664444444411111111010111117053728427254560 666666666666444444444444111111111111110111120001285006551886339515345458 446552991649363.....35860 655665666615903955250395193258..........9324452078 Day 119 503.1 47 30 27 .. 27 55 17 70 .. 30 6665666666 3126627106 1093768536 .......... 3159027068 Day 122 558.2 6566 5906 3360 .... 3240 656561929484330.....67829 Day 126 47555 40138 18800 ..... 34390 Day 133 54755 15238 21336 ..... 52798 Day 140 475555280348519.....37615 Day 147 47555 64292 62962 ..... 62085 501 Day 154 745656730254389.....15808 DuPont-4739 Day 161 475 673 512 ... 494 56 30 24 .. 02 Does notcontain TSCACBI ! 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50 mg/kg/day 666666666666666666666666666666666644444444444444444444444444444444441111111111111111111111111111111111333332333333223232323233322223333396135611946294167907575718573731646936502187111093874412065686138858 641323 111 878 509 ... 844 115887 ..92 111211111111111111111121112111878099786597899778988807680998088490339978465631554441098691..............................163775103517632981432330815559 2211 1189 6671 .... 7221 217.3 112222111121222112891300899909010992484692775067449062..................353084029908664606 211221122223990297011414545568171...........41301179281 206.4 Day 14 22 20 38 .. 95 22 31 92 .. 94 222222222222124531001179021694494...........33899336122 222222222222222222225033131351223102347219566893771399546038....................55314500980848047909 Day 21 222222222415251356164516602.........941650645 222222222222542232634552614906636267............360681633885 22 25 63 .. 96 222222222222823364235695695975507761............235333251525 Day 28 22222 64656 90305 ..... 02655 222222222222222246787533559478643161124131134398................5491247927327127 223 481 807 ... 957 248.9 222222225785359703703537........15778088 32 37 13 .. 36 Day 35 222222222222222222546564788766356959829366133443514840..................991905266995963867 2222 7855 9676 .... 3032 232222222223825679646773286274971968............510680122557 282.6 Day 42 2222 9585 2549 .... 5544 222222222223222222332223222323276898976577169996703678186708687172972767061811506963431841047...............................6352566137929610611505523318008 Day 49 222222222322222323332233222322223376587689908657726001671468819679617797951602068812048034117292069286..................................1527551975416306268914510333259228 303.8 DuPont-4739 Day 56 222 969 990 ... 668 222233223222323332326989019806882710261720488084586893450705....................38474161340400088090 322232223332678929681709559330792256............366894438452 Sanitized. Does notcontain TSCACB1 519 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 63 Day 69 Female, IV - 50 mg/kg/day 666644441111333359635696 666666666666666666444444444444444444111111111111111111233332333232322323715192947614169067231181104127937408 666666666666444444444444111111111111223333332233757576418313386065856188 641323 223322332223233332322233322222233237826780288929800180787103959798118244945955064247051170542279385907106...................................37454344974818839430886825900056600 3233 3711 6483 .... 7561 3233 4701 8616 .... 3554 223223233292892987081889398448..........3666067855 ' 33 80 14 .. 05 Day 70 223333332222233 880132017988601 407872319167281 ............... 330511917884614 Day 77 232333332323380922300807031659813466008.............3399659422884 23 70 95 .. 15 Day 84 223333232333233913329080080712413488361290206...............322221047526478 Day 91 Day 92 3232 0807 0759 .... 9144 332333332333291012070207860869801...........35455904456 22 86 36 .. 38 223 870 966 ... 800 ' 332331280010109.....63157 Day 99 32233 19812 55628 ..... 62258 DuPont-4739 Day 106 23233 92922 45725 ..... 12088 empanySanitized. Does notcontain TSCAcm 520 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________ INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 112 Day 119 Female, IV - 50 mg/kg/day 664411339669 666664444411111333231536135602 666664444411111323331969218111 664411324407 641319 666644441111232367903874 - 666666666664444444444411111111111232223233237571575873341258606618 664411337138 666444111333264358 323332902266972 .....66122 33333 30122 25615 ..... 12944 Day 123 Day 126 32333 39122 66879 ..... 08810 Day 133 3333 4412 9185 .... 0830 336.2 Day 140 3333 1234 0244 .... 4786 341.6 Day 147 3333 1243 3089 .... 2948 347.5 Day 154 33333 50246 67644 ..... 24189 DuPont-4739 Day 161 333304529745....3051 355.4 CompanySanitized. Does noteemWn ***** 521 G&mpmfSanitized. Does notcontain tsca cm w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________ INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 168 Day 175 Female, IV - 50 mg/kg/day 666666666666666444444444444444111111111111111323323333323333196961129441635381602111079965 666666666666666666664444444444444444444411111111111111111111332323223322333223337276675575183314977033253418605618887684 33333 61344 17247 ..... 66905 333337333558961.....22026 Day 182 33333 52131 06844 ..... 64999 522 DuPont-4739 Does note ...... CompB">' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 0 Day 7 Female, VI - 250 mg/kg/day 666644441111222359691298 666666666666666666666666666666644444444444444444444444444444441111111111111111111111111111111333333322332323322322333222332301363343283963786387360775860473647937981320552226783521202249 111111221111111111111117779971187588987699786833935281939106269993566.......................09288022885123793560100 112189078545....5920 211121111989079905484502........37093358 222222222212211121122221212121221102112012129129980991450827182910995205339524548724001703022825826694..................................1889675088155927411414949816976490 212.3 Day 14 222222122221222222222221334118514491421161404027358839466234200533895.......................34919058743048255388878 222222222222452434142404229396902584............199789386615 Day 21 222222222222222222222222222222222223757663673306164547794383036332628137454250695233519858900117078139664...................................14872675362201932403978160739245648 Day 28 222222222223222222222222222332222224968847953705659618468415540147284863517850175443972477237253327008283...................................34472787589254992603289763748635500 Day 35 232222232234243855195092578955330...........86947589478 222223222232222222223222586491895807619466860693566241963611965789337592........................348444562391452748431848 Day 42 333222232222303368630765813520040247901.............9429131021191 232222222281735487972974426908..........2317323407 22 59 35 .. 92 33 02 20 .. 35 232323329060606065125460........33170486 Day 49 2232 9514 2377 .... 5708 223 770 691 ... 086 2322332 9166347 5123731 ....... 8816608 232233322322233222322718600269197405987148423484535545420593431.....................923502762862964955949 DuPont-4739 Day 56 2232 9624 7657 .... 9747 222323332332232223388509010026571887554840867072813625635...................3046655871793998848 233233333232803711422705996234944339............394680655726 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 63 Day 69 Female, VI - 250 mg/kg/day 666444111232995281 641269 666666666666666664444444444444444411111111111111111222223333322332333778587668630047737102622322252459 664411223385 666666666666444444444444111111111111333332333323031643239836396773842190 3232 0736 6862 .... 3757 232332333322233323232322322332381812615227940009192927608866713694949484499160235196410831235...............................3113463781034043616050511611700 ' 332323233332223232138370636319581929520062938143681614..................498737113997130609 23 81 67 .. 36 Day 70 2323 7281 1253 .... 7577 322223323332769876813096747485465...........58825109696 Day 77 2323 7272 7139 .... 9277 322233233333768968330008751732437...........31841288060 Day 84 224323323322333850793682098215172232823914884...............542088820021476 Day 91 232382850321....5598 332224323333586907832086224584535...........28906551359 Day 92 223323332398856200635475500651..........5696914319 Day 99 223338604756231.....30261 DuPont-4739 Day 106 33223 47860 47937 ..... 82686 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 112 Day 119 Female, VI - 250 mg/kg/day 666666666666666666666666664444444444444444444444444411111111111111111111111111323332333222232322322322336339684678396055763778879033520142528292219222106785 664411323339 666644441111333263427478 664411330339 641316 33322 05897 61557 ..... 35984 33322 06999 83683 ..... 31041 Day 123 Day 126 33323 16990 44681 ..... 44706 Day 133 33343 71200 05002 ..... 76408 Day 140 33433 17001 74764 ..... 34768 Day 147 33433 27112 37010 ..... 71157 Day 154 34333 91212 00373 ..... 75428 Day 161 33433 19123 84631 ..... 77015 Company Sanitized. Does notcontain TSCCEi) 525 __ _ _ w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________ __________________________DuPont-4739 INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 168 Day 175 Female, VI - 250 mg/kg/day 666666666664444444444411111111111333322332326678567049932521992482 666666666666666666666666444444444444444444444444111111111111111111111111323333223333323223222223033983156334667788733230335219620347722106789825 44333 10223 31282 ..... 72574 3433 9242 7609 .... 6207 341.8 Day 182 433331210770054.....34855 Does no!contain TSCACBI 526 Company Sanitized Does notcontain nm 'w ' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 0 Day 7 Female, VIII - 1000 mg/kg/day 666666666666664444444444444411111111111111223332323322337928130792560959604709079415 666666666666664444444444444411111111111111334222343332229504760206454833268510783424 666666666666666664444444444444444411111111111111111222333223322323337497288355348569733609524620876697 11 86 80 .. 77 175.4 174.7 195.2 1112 7780 3799 .... 7179 221111111111110787788789788598514275773.............5202333685401 111898414...609 111 889 691 ... 057 111221111177008798977912088488..........1526206059 2211 0078 1372 .... 4800 111 897 479 ... 828 21 08 47 .. 24 212112222221112112112221221222221221122222109199134200999099299021092902301913993100292276671296146954420832198061463476082030879...........................................5765977913386223396722390367606541623958775 Day 14 212222222222222222222221902300445332122101501209850053797607117771352.......................33193060538869836628877 222222222222222222222234233111053402622432521952536999388308090522......................3109230617021894715650 Day 21 2222 1113 6929 .... 5118 252.2 2222 1265 6245 .... 1440 281.4 266.8 22 26 61 .. 77 22222 23432 87196 ..... 07742 22222222222 38222554452 07509966613 ........... 33206511157 222 428 003 ... 564 222222222222213572461833325791160448276.............3378075198115 Day 28 222222222322222222222222222322671488085844475343446757367407814731025748461767657...........................673382419697291532418678784 222222222222222222 844596733495596383 019967988690104888 .................. 385614242228007044 Day 35 222222222343483598227707467.........015163304 232222222222222222222222222322232222915956653373558967756455576058419494279170237849772854824781902963584968....................................320434946197387114385544181868840296 Day 42 222 454 242 ... 906 277.8 . 322 026 035 ... 356 3232 1929 3609 .... 2862 2322 7056 5656 .... 0629 22 77 33 .. 12 223222330465363567......301029 32 18 89 .. 78 229919 ..64 222238676269284.....22886 222233566701055817......318818 232232 617517 870413 ...... 356534 260.6 527 Day 49 222222232332322222223222322322232322232232232355793729328176875640579299067739058736718717601648019927436140328340224497934120138332663.............................................110628205073336273749515523878042178450304155 DuPont-4739 Day 56 222245592048....3528 322331371010372.....38877 332232222232222323222222323222323232509728885415879291969797390588372727374583520939008539650902010872032606....................................122702345846785469901953261495866116 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-4739 INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 63 Day 69 Day 70 Day 77 Day 84 Day 91 Day 92 Day 99 Day 106 Female, VIII - 1000 mg/kg/day ! 666644441111223397289560 666666666666664444444444444411111111111111432323233223239060717925693032518490794570 666666666666664444444444444411111111111111222332222433327495454830062438633424017806 666666666644444444441111111111323223233355583848272662473590 666444111333976976 2222 5945 6353 .... 9557 307.7 245.3 2333 8216 5592 .... 3481 223338710306360.....32498 229832 ..15 222236855133575.....34348 23233 92703 14207 ..... 36852 313.5 226739..95 . 233322830157207288......139146 232322748488928173......323930 322289855...367 233323222223333233227401516868625026109652288497664024608922....................99405335535295365257 ' 2223 5550 2979 .... 6556 233333322329417202990470190803254...........36609999789 223232232289386995988552622846..........7166066798 222 566 324 ... 591 303.8 233333333333182200205249538018654...........32858756018 333222360789907123160.......0521919 323380772...155 22233 57613 80250 ..... 32469 233333233352821580073530809012..........2205696629 323332322239601979898082555368..........5029049289 223237625036838.....19786 233225014530343.....77230 223333333 951539325 235612521 ......... 366148071 ' 223339145788....9507 371.2 291.0 233323333280049600891495052257..........3547539779 33333 43500 39712 ..... 60480 233333323391250909806029621709..........9564162872 33333 54611 55350 ..... 51900 333433091113227422......570944 3333 0135 2336 .... 9011 Does notcontain TSCAeat 528 Does no!contain TSCACBf -J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________________ Day 112 Day 119 Female, VIII - 1000 mg/kg/day 641299 666644441111233372815604 641237 641300 641279 666666666644444444441111111111332233342292560990760794153285 333336461109581.....21209 333336562158822.....39600 664411234260 664411345031 666666444444111111333222406548378424 666666644444441111111222223373944723063809 664411338857 666666664444444411111111232233338535569722466697 3343333333 3131012360 4781792938 .......... 2009057661 334333 414104 280172 ...... 261807 333323519583 ....2178 INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS Day 123 Day 126 Day 133 Day 140 Day 147 333336673219324.....24067 33333 87632 73847 ..... 26268 33 97 89 .. 89 333 732 969 ... 907 43333 18832 13378 ..... 74296 33432 20108 --10148a..... 35219 3332 0149 2303 .... 2514 aAnimal number 641090 was found dead on test day 123. 529 Day 154 44333 20854 32502 ..... 38602 DuPont-4739 Day 161 44433 20053 06342 ..... 99250 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL BODY WEIGHTS (g) OF FEMALE RATS CompanySwBbed. Doesno!contain TSC Day 168 Day 175 Female, VIII - 1000 mg/kg/day 666666666666666666666666666666666666666666666444444444444444444444444444444444444444444444111111111111111111111111111111111111111111111333332223322343422222333323332332332322222332556978354748905054394728242068096107956797283626972463337323142068095760784155409094895607 44433 32163 32318 ..... 51449 ^444 312 602 ... 362 336481..27 Day 182 43333 08942 12995 ..... 33698 530 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX C INDIVIDUAL FOOD CONSUMPTION DATA 531 CompanySanftteed. Doesnnfew9s*' * '** H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 Critical Dates INDIVIDUAL FOOD CONSUMPTION DATA EXPLANATORY NOTES Day 69 Male and female rats designated for reproduction evaluations were co-housed. Last day of food consumption data collection for these animals. Day 83 Rats designated for the 3-month recovery period were temporarily housed in metabolism cages for urine and feces collection. Last day of food consumption data collection for these animals during the 90-day dosing period. Day 90 Last day of food consumption data collection for male rats designated for the 90-day exposure period. Day 91 Last day of food consumption data collection for female rats designated for 90-day exposure period. Food consumption data collection continues for animals designated for the one-month and 3-month recovery periods. Day 119 Last day of food consumption data collection for animals designated for the one-month and 3-month recovery periods. 532 Sanitized. DoesnotcontainT8CA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 7 Male, I - 0 mg/kg/day 666666644444441111111112200145216749524907 666666666644444444441111111111012002121161099201716564804724 666644441111102106050048 666644441111011177089568 666666666644444444441111111111001101111157765304283248257056 666666666644444444441111111111011112011086520180583593155544 2232222223322233375656956426501690.................24090069152148816 32322222130639787892..........7610913356 _a 3222222223223322216678876917907948.................33516139693892848 Day 14 33222233 22797614 ........ 03582440 34.4 222232869638......331667 3332 0739 .... 4056 2385 ..88 22336217....9548 32223332232333323330868028519000117618...................6590202999866046067 28.4 Day 21 232333233332323333333324233243333333323322333916003230813970320938390730705008803043198255.............................................497883266763724019970624183222648504362068141 Day 28 23323 69674 ..... 29798 33233233336231790027..........6062486061 33 58 .. 55 2392 ..87 3333333333323333233334233310310322221830018737029350..........................32129015890074474775839596 Day 35 332233437724......347428 233 612 ... 516 23332422223232336311806659493769................6094284314650014 2333333233322323332393010118142928990416....................31290502380728578578 Day 42 3332307694.....26055 32323333232322322332332332818282299937678897925919.........................5270439802132194474967920 233333322332233912213387049802...............458502145583451 Day 49 32232223 29407792 ........ 58991118 33233333333223223222324233233233322339320123153398289078689171289580518770.....................................7425538456788260207559004028997274650 Day 56 332333359086......946514 333333333232324232323334322333331027001819722967792130487806..............................935233501659119923462370591468 3333333322430641........49024990 30.9 Feeder misweighed. Data excluded from statistical analyses. 533 DuPont-4739 Day 63 333333 500376 ...... 656618 343 430 ... 582 322 552 ... 290 322358...396 37.5 38.9 2423 3982 .... 4357 33 13 .. 25 23 80 .. 81 33232786....1267 222232898928......303954 30.3 33.1 3233 4955 .... 4846 333342...226 30.5 Day 3334323332333433332242000821880430049889....................72130161310327212451 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 70 Male, I - 0 mg/kg/day 666666666666666666444444444444444444111111111111111111112200201100122112452167094761920011952490647265804447 323333234322322072756921599688...............837541309482671 641158 666666444444111111110110006877600859 666666666666666666664444444444444444444411111111111111111111110111001011010121115282854307768580106533356205724844555159 2333333323 8835221132 .......... 3890749965 Day 77 3233308265.....33696 33343223234021577880..........6577667351 2333333333 8243001220 .......... 5552351524 Day 83 223 644 ... 350 23 60 .. 10 Day 84 22333 93505 ..... 26930 23343 84002 ..... 00117 2333323333 8324900122 .......... 3973317850 Day 90 23333323436004628113..........2376102316 Day 91 2333 8313 .... 1794 322233 096922 ...... 336996 Day 99 Day 106 2223283718.....57896 2232294657.....72197 2333 6210 .... 7905 322232 387908 ...... 103470 2333322333 4411499320 .......... 3129514556 Day 112 22322 73856 ..... 20825 2333322233 3330189912 .......... 6758182521 DuPont-4739 Day 119 22322 96957 ..... 34621 233332333 744448023 ......... 333248240 30.9 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 7 Day 14 Male, III - 5 0 mg/kg/day 666666666666666666666666666666666664444444444444444444444444444444444411111111111111111111111111111111111110111111012111011120110000120111210787796316229255619081297554280417933114138121449690399188136545786888 3222223232223222222222332222223223368799192783228381884877867878807501...................................32377586395832122929227608604171756 2222 8898 .... 3590 23233232333223322323333323332239191130977629847101743329123980...............................2371090328241607394925904644746 Day 21 2333333333333233332332333333332333393392220020918710077151836114181045...................................33155919594172063311821668876212147 Day 28 3233323 1821294 ....... 4266676 32 49 .. 65 3332333323233332333322333305388004811957093578951956..........................28023266879103366718682022 Day 35 3323332232332323323233332332207972802640609349852754908129.............................56154553492387128581267894978 233333915002......326698 Day 42 3233233332233332329109440854071290.................33315914449868705 33 40 .. 64 33332333333232223241710736090976................3325104262159404 Day 49 2222233 8985802 ....... 7137887 2322233333 6359167150 .......... 2332290516 33 34 .. 39 33333233332333232316190200711577................2929620781298815 Day 56 3332333 3315400 ....... 6029907 23 82 .. 83 3223223333333219868608430216..............16340319905860 333332333333203519121226............634202737859 Day 63 323333 073112 ...... 221900 33.5 32 58 .. 47 3333333223332232333233232222810408911095442393373879..........................30317291037879336610555408 Day 69 36.7 32.7 .332323 284876 ...... 430640 433333333 130121345 ......... 499841209 333 331 ... 280 CompanySanitized. Does no!containTSCACBI 535 I ! 1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 70 ;Day 77 Male, III - 50 mg/kg/day 666666666666666664444444444444444411111111111111111121012110010001211295620488597541734490584175836688 22223333333339792144170912.............1630007108961 3363 ..71 3332333 0407210 ....... 2264858 33233223 50399896 ........ 33678259 666666644444441111111111201162909123999188 641138 666666644444441111111111110170871653311126 666444111110927114 Day 83 222 685 ... 324 33 20.. 24 Day 84 3332332333 0248181832 .......... 3462994540 Day 90 33223333230221588971..........3863820760 Day 91 Day 99 Day 106 32223 09594 ..... 32751 2223 9485 .... 3356 33.5 Day 112 2223 7474 .... 2244 31.9 DuPont-4739 Day 119 2295 ..56 233952 ...351 contain TSCA CB! 536 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________________ DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 7 Day 14 Male, V - 250 mg/kg/day 666666644444441111111111212069309062042701 666666666666666666666666666644444444444444444444444444441111111111111111111111111111111111001111011111101000111147637278592821812508367948742941605215246907482975601708 2332222232222232222222222223222222243397998158777913548397855073378586...................................46107570275751236917961706525862988 323232 140919 ...... 334064 3323223233323333332322222233350198580812371423185698847113.............................09965937360459152607771972705 Day 21 323323 633943 ...... 370570 322333322332233233190231798207732930..................357678245994598182 2333333323385714063903...........96478919086 Day 28 3232 2724 .... 2074 32232223323 28938660293 ........... 23084171960 2332323223333333322382080738313313814893....................34539872647201953802 Day 35 3232 0528 .... 3291 23322332332223322233333232223338328924711998023920693181956201...............................6979616109061508255145761147811 Day 42 323232233333322223222233222332323346192893012007767098909458115152916...................................93044627246975725716365012184580604 Day 49 2222322223388067955901...........33224765520 32322223322323327934389201827636................3464417593361691 2233332370251073........32664186 Day 56 33333322654048.......3007923 2233 9632 .... 5858 332233322726715178.........167391050 33334133....3965 32332332232925520882..........4030555788 Day 63 3233333223219614326629...........22577484160 332 327 ... 100 3333332233323322233206523682009317782249....................92509779966550707875 Day 69 3332332333333233332241964152314713922386....................33250332410250390024 P 3 r o s i . UJ8IU0SiOU8600 537 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 70 Day 77 Male, V - 250 mg/kg/day 666666666666666666666666444444444444444444444444111111111111111111111111110112201010110111010111817900668373703976259484095020129761624705680178 32333 74101 ..... 33167 232333 905020 ...... 277064 232 907 ... 369 22323323322 87392190296 ........... 53721065776 223 893 ... 358 641117 664411018224 641151 666666444444111111111111427892209452 641164 Day 83 24.0 232509 ...678 Day 84 2222 9488.... 1567 33 02 .. 34 2223 7873 .... 2784 Day 90 2223223232 5970657601 .......... 3968778889 Day 91 Day 99 Day 106 25.1 26.9 232526...949 232758...334 Day 112 28.1 233960 ...602 DuPont-4739 Day H i 30.1 333260 ...424 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 7 Day 14 Male, VII - 1000 mg/kg/day. 666666666666666666666666666666666666666644444444444444444444444444444444444444441111111111111111111111111111111111111111202100110100211110120202000111211211201009256936735890963899150710671518514819661537772670763569903624880787220201556247 666664444411111212111504833339 2222222222223222232223233223332222232332232265487966654318757036404117342077756070386069............................................34781738480632143343338455618188932267541644 34.5 222222222222332322223233323333222233333223223778699885583719467571531482532896802143974585.............................................375802079965510096521952294073300551232515841 Day 21 22223232223143236978091896191285................9521004175615385 22223233323333332233333232339698364319577501790206397713............................3185515398847758272757579617 37.7 Day 28 2222223222224223385736607682509726.................47905917451494720 2223233 7750323 ....... 5707487 2233 9855 .... 5627 332222322323037465099082............382165822266 2365 ..56 232 677 ... 625 Day 35 2222222222224323222232256867047779341966568148.......................64877399542167160885478 33233332322223333232331175203815594205285725......................1104238884972365976657 Day 42 222222866573......387274 232222323322223222223323222223323223223727534980177782547794190756582195945891.......................................600640332334649730154297738125331788548 Day 49 222222222222433222222223323333222223323323223564366364564210987875770183422656491091445695.............................................337470865476114239054529757540644842888980508 Day 56 222222 996878 ...... 315113 232222432222233233322333222223332322333608844028887632513059033695560338245710.......................................309692935078854849694451615477399738109 Day 63 322222096876......638788 25.7 32220985 ....5467 23 27 .. 37 3332222307783872........39756888 233 523 ... 269 29.7 333 024 ... 399 3322 3578 .... 2920 2223 6581.... 0674 233323 530360 .4 .....2715S 223 792 ... 396 DuPont-4739 Day 69 323333 33223333332223 740113 00552467708661 ..90 ..23 ...376 .2 ..29 ....2445 .6 ...,06 ....84 .,6 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY MALE RATS Day 70 Day 77 Male, VII - 1000 mg/kg/day 666666666666666644444444444444441111111111111111202110001101011209258693673561091537677267079056 2222222 9957987 ....... 4996751 32222333 07950632 ........ 56495108 222 985 ... 297 232222223323 806578272178 ............ 452021642500 664411201926 641068 664411009534 666444111212090738 641139 666666666444444444111111111001111122871585171072220180 641145 666666666644444444441111111111211201120115406681983333745629 33233333334350161356..........1306067298 33333333234700440362..........9095786191 Day 83 22323 42363 ..... 42761 Day 84 22222222227455558585..........1499655790 22322233334144491205..........2187654467 Day 90 2222222222 9453635737 .......... 3346410616 Day 91 3222232122 1980533299 .......... 1534656566 Day 99 Day 106 2322391327.....39058 3223314441.....99726 2223333333 9680158455 .......... 0492554807 30.3 333232333566565354.........971986987 Day 112 22333 54422 ..... 31495 30.2 332323333465761233.........596047670 DuPont-4739 Day 119 32233 37662 ..... 15069 32.8 233332333 646583265 ......... 334529708 CempanySanitized. Does notcontainTSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 7 Day 14 Female, II - 0 mg/kg/day 666666666666666666666664444444444444444444444411111111111111111111111223223222332223333233335889944443084738943322173430495059511284567480 666666666644444444441111111111333242333310585604487389516968 122221122211111121111900219730298778908878.....................792677853913252805955 21 08 .. 25 21 09 .. 71 21213221 09192039 ........ 87611687 222122222252121222221222222222221222846491061828001082221243221148.................................333333191606744271470412599601361 641308 19.0 19.8 664411225839 12 91 .. 05 19.1 23.6 666666666444444444111111111233333224986385260434119560 222222111 242030998 ......... 333127878 212222111929323089.........339771967 Day 21 222212953092 ......751617 222222222222222222122222222122859200231211413310933200215805..............................103604721751177551954219496087 222221122 041318913 ......... 331007258 Day 28 2222 2710 .... 1467 21.2 3221 5806 .... 3550 222212 143290 ...... 309959 23.8 22222222222 24234502413 ........... 39338689864 222222 333236 ...... 320019 20.8 2222222222 5528131230 .......... 3473447670 '2 3 . 1 Day 35 2221223222222212222222221 1412023811800239411000339 ......................... 3503227996498880699771788 2222222222222221111 4202235322422117999 ................... 3252796735286686818 21.5 Day 42 222222 251620 ...... 331702 23322222222222222223221203111211145122...................3320142655677841707 22222222222222222222 23241314262122432142 .................... 33273313455318650806 Day 49 1221112122222212221211192378829422031820209928.......................33229023379005601121654 22 00 .. 02 2222222222212222222222310411052831414212....................33951880056271575491 Day 56 12222139550490.......9729951 22 15 .. 40 2222122221222212221221222100119020391133814370391209..........................16156876499784920686044657 2222222221 2144211018 .......... 3333160068 Day 63 222222223111222 054021360999421 ............... 389986446971590 2222222222222211222122222212102205033611124892129033233918.............................33734550579113434596957841089 22.0 DuPont-4739 Day 69 22222222221222222222 41211233538135033301 .................... 79905458478416465548 541 Bossnotcontain TSCACBl I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 70 Day 77 Female, II - 0 mg/kg/day 666664444411111222338594837044 664411229439 666666666664444444444411111111111233222233324308483943455951864570 12222 97502 ..... 23602 21.8 222222222526141020.........337280280 1221 8469 .... 6224 11222122222 79406830332 ........... 32507516104 666666644444441111111333333323872154291808 664411321575 666666664444444411111111324233330806044889316968 666666666644444444441111111111243333223268305289656310951443 22222222220162203416..........7217632267 22222222222103303242..........4199729087 Day 83 21222 29220 ..... 58707 Day 84 22221560....2184 122222 934051 ...... 606390 26.0 222222222313062423.........208335430 Day 91 12219359....9650 122222716081......329529 20.7 221222122339002392.........265544476 Day 99 Day 106 Day 112 Day 119 22222 40843 ..... 55511 2222114068.....39749 22222 52312 ..... 22212 '2222 6122.... 6570 15.9 22.0 222222222121124173.........321491919 22222222221025434332..........7942908181 22222222214221312458..........5510219028 2222222222 6042421003 .......... 3614549418 542 DuPont-4739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 7 Day 14 Female, IV - 50 mg/kg/day 666666444444111111332333156963250696 666666666444444444111111111333332323621944119113107918 666666666444444444111111111223232223776075597623441878 666666666664444444444411111111111333333322332764571383133580651688 112111 960897 ...... 976816 2222112222111222111111122122130127802693290109998998008018.............................56025278253251883862829906951 20.8 122 810 ... 678 22 01 .. 45 20.1 22 22 .. 60 2222221225130080........37435959 221222038223......847969 25.4 221 129 ... 018 22221 30391 ..... 22512 2226 ..67 23.8 Day 21 222222222212211222122122312211293289119011.....................924613679862537291705 2222222112222134092134291669..............39658110450768 Day 28 22222222222222221229327244314030365844...................4018726480830608740 22222222222222222845116044725445................2442263124317768 Day 35 222221 110329 ...... 150018 2222222221222122222212222222252023400296934534123913623310.............................35557384908937104626784983448 Day 42 22222225....2054 222 513 ... 558 _a 222222222222221222222222222661422753216948234334251414...........................333893405850719152877745416 Day 49 11 99 .. 90 22 01 .. 01 2231 ..09 222222222211231211.........229685277. 22 12 .. 18 25.2 2222221222222255275593452362..............03563910950808 2202 ..01 25.1 Day 56 22222311200148.......2557070 2121112290818863........27999001 22 00 .. 07 22222222122221224231020790024712................3324250306369784 22 42 .. 04 Day 63 2122 6631 .... 5299 26.4 2222221222222122222222222222208337691630179262402220250514.............................31751159187223316380648471779 22.2 DuPont-4739 Day 69 24.2 222 123... 456 27.8 22220645.... 5591 2222 3032 .... 9290 2222 3451.... 3154 21 79 .. 06 22.9 ^^Peederjmiswei^iedj^^Data^exciudedjfirmnsftistiMl^maWses. 543 J H90--2D46a1y6G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations_____________________________ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 70 Day 77 Female, IV - 50 mg/kg/day 666644441111333396356965 1222 9102 .... 0178 2212 4191 .... 5267 641260 24.9 24.9 641312 20.9 25.7 666666666666666666666444444444444444444444111111111111111111111333233323222332223333129149661497707575751311108139774842860615 222 135 ... 906 222222314023......330361 222144...361 222222 402124 ...... 044481 666666644444441111111223333383731646138858 641323 Day 83 12212 81374 ..... 42986 Day 84 22221022....4561 222222 403231 ...... 917607 Day 91 2212 0090 .... 2702 2222 ..57 22221120 ....7719 Day 99 Day 106 Day 112 Day 119 2122228054.....45280 2121239361.....34345 2122107369.....63576 2222123039.....39100 DuPont-4739 Doesnotcontain TSCACB 544 AsffljpanjrSanHfzed. Dees eel eHa! 'y H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations_____ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 7 Day 14 Female, VI - 250 mg/kg/day 666666664444444411111111323322326407969524292981 666666664444444411111111333332226780776335252122 666666666666666666644444444444444444441111111111111111111333333233332222222303139833463263357883963219477580382706 21213807....3712 222212212111121212211112112211323291290996791921978842791099..............................294914625569641844705810329844 21.6 212112392892......409888 17.0 12 93 .. 40 2222222222222112222221212241320554331349121320270904..........................66532924461492108812161086 Day 21 22221 60439 ..... 60758 222221222222221212222222112221610339533439051942302231983507..............................023398498318120056112916675091 Day 28 222221222222232222222221666592021315315135204129........................274298016436558957061151 _a 22228452....2269 __a 2222225233.....30418 Day 35 1121222298394120........08859664 112222122222221222222222222984202934221476304133133114...........................910141893256489083155627415 Day 42 222212360491......048585 20.4 2222264470.....25020 222 326 ... 031 25.0 222 404 ... 142 222222053430......114209 222222222044317343.........993467418 21.3 Day 49 2122222222122221222122221121222111108031337049124195249542628472118978...................................31453910574651283183061674636492478 Day 56 12212222112222222222122229237721399104314401587212.........................8317635624040087322222290 22 54 .. 27 2252 ..41 122212932803......226728 Day 63 22222122222213307394612119.............4449585330405 11212222212211222222229839943011279525012112......................4415584166961032773798 DuPont-4739 Day 69 1122221222222122222298333096335492204110....................48729211173266354707 i Feeder misweighed. Data excluded from statistical analyses. 545 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________ INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 70 Day 77 Day 83 Day 84 Day 91 Day 99 Day 106 Day 112 Day 119 Female, VI - 250 mg/kg/day 641398 22.8 641251 21.2 641292 20.8 641269 19.1 641379 28.1 641302 24.4 641244 20.0 641362 18.8 641363 26.7 641375 24.5 641382 22.4 641262 23.5 641232 23.0 641305 641372 641271 23.5 21.1 641280 641252 641386 641277 641233 641238 641235 641392 641360 641381 641333 641239 641228 641334 641347 641367 641303 641339 641316 21.1 19.2 22.8 20.2 25.4 24.3 20.5 20.5 29.5 23.7 21.9 24.0 25.2 24.8 19.4 20.6 26.6 25.1 21.7 18.9 18.5 20.1 25.5 19.2 25.3 22.7 19.2 19.8 27.6 22.6 18.9 17.3 24.3 18.9 25.0 22.3 18.9 20.7 25.4 23.8 22.9 20.8 25.7 23.4 16.9 22.1 23.0 24.7 24.8 21.1 21.9 25.3 25.3 24.3 22.3 21.9 26.1 26.5 23.0 24.5 DuPont-4739 Doesnotcontain TSCACBI 546 ' " H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 7 Day 14 Female, VIII - 1000 mg/kg/day 641299 641275 641326 641380 641314 641237 641300 641279 641390 641327 641259 641264 641301 641395 641278 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242 641284 641230 641273 641296 641248 641370 641243 641329 641385 641387 641282 641234 641256 641356 641352 641366 641399 641377 20.7 19.1 18.8 21.3 21.5 20.8 19.4 22.5 22.4 21.5 23.1 19.0 21.2 19.0 19.6 19.7 18.9 18.4 18.1 20.5 18.5 20.2 19.3 20.7 19.1 18.6 20.0 22.0 19.7 19.7 16.3 23.5 ' 19.7 23.0 18.9 17.0 19.5 23.7 21.0 17.1 23.8 19.9 19.8 21.0 18.9 19.2 22.3 19.9 23.0 18.8 20.3 16.9 23.7 22.7 22.9 21.7 21.3 24.2 24.9 22.7 21.0 21.2 19.8 19.5 23.4 20.2 21.0 21.7 22.2 24.2 21.2 21.3 21.6 21.1 20.6 15.4 26.1 22.3 24.5 20.6 20.9 21.2 25.6 21.6 18.9 24.2 20.6 18.8 23.0 21.5 Day 21 19.3 19.5 18.4 22.4 23.5 21.3 20.1 25.4 22.3 15.2 23.8 20.0 25.1 19.7 21.5 20.9 22.4 19.9 19.5 26.4 20.8 21.3 19.8 21.0 22.8 21.7 23.2 24.2 22.3 21.8 20.4 29.7 20.9 23.1 19.3 20.0 20.2 27.4 21.1 18.9 22.5 19.8 19.6 23.9 20.0 Day 28 19.8 19.8 22.0 24.3 22.7 21.5 20.9 25.6 25.3 _a 25.1 24.8 24.8 21.2 22.0 20.7 23.5 20.3 19.2 21.5 22.2 33.8 20.4 23.0 24.0 21.6 26.1 25.8 23.9 21.6 22.8 26.6 21.2 25.0 20.5 23.4 20.2 25.5 20.6 19.5 23.1 20.3 21.5 23.1 19.7 Day 35 18.8 19.4 19.6 11.6 21.9 20.9 19.5 25.0 21.9 25.2 26.6 22.1 21.8 21.4 23.1 21.2 21.7 18.3 17.7 20.5 19.1 22.9 22.0 22.9 24.1 21.0 22.2 23.4 20.2 21.5 21.8 27.3 17.6 17.7 20.2 20.7 20.3 26.5 20.7 19.2 22.4 19.4 17.6 21.9 18.5 Day 42 20.7 20.3 22.0 26.1 23.0 19.4 20.5 25.9 23.8 24.6 25.8 23.9 24.3 20.7 22.1 22.2 24.6 18.6 17.4 24.8 21.8 22.8 20.2 23.7 26.5 23.9 25.7 23.5 21.4 22.0 21.0 25.3 22.0 25.8 20.7 22.6 19.0 23.2 21.5 15.9 26.2 21.1 22.3 23.4 22.7 Day 49 15.5 17.9 20.6 21.7 19.3 21.1 19.1 23.1 21.7 25.0 28.1 25.0 24.0 20.3 21.3 20.3 22.7 18.9 19.3 24.0 21.0 23.0 19.2 22.8 26.3 21.5 22.7 25.0 21.6 21.4 21.6 23.6 23.2 24.0 20.6 23.6 21.3 26.1 20.3 18.2 21.7 20.8 22.1 21.6 21.2 Day 56 17.9 16.6 21.2 27.0 22.7 19.6 19.3 23.0 23.9 26.8 20.4 27.7 25.0 20.3 23.0 21.1 21.9 17.0 16.7 20.9 20.3 21.5 18.5 20.2 22.2 18.4 23.2 18.9 17.7 22.6 19.5 21.3 21.1 20.3 19.4 23.5 20.3 25.0 20.1 17.3 25.9 19.8 21.8 21.1 21.2 Day 63 18.0 19.7 19.9 52.8 21.6 21.2 21.6 24.1 24.3 26.5 25.4 25.8 24.2 21.0 21.2 20.7 22.0 18.5 17.4 19.9 20.1 20.3 15.8 21.0 22.3 18.4 19.3 24.5 18.5 20.8 20.6 22.7 22.2 24.4 18.8 20.0 19.1 23.9 20.6 18.2 25.5 19.1 25.0 21.5 21.0 Day 69 21.5 22.3 17.1 221820... 084 22.7 16.8 22.2 25.7 20.7 22.4 24.9 20.0 23.0 20.8 23.2 22.8 25.7 20.2 Boss nofcontain tw** Feeder misweighed. Date excluded from statistical analyses. 547 rfamsssa&s H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY FEMALE RATS Day 70 Day 77 Female, VIII - 1000 mg/kg/day 641299 641275 641326 641380 641314 641237 641300 641279 641390 641327 641259 641264 641301 641395 641278 641265 641393 641402 641246 641320 641353 641401 641307 641368 641343 641254 641242 641284 641230 641273 641296 641248 641370 641243 641329 641385 641387 641282 641234 641256 641356 641352 641366 641399 641377 19.0 21.0 19.1 26.8 22.6 21.5 19.6 24.6 22.1 24.8 25.5 25.7 20.4 21.0 22.5 21.9 19.6 25.1 21.8 18.6 27.9 21.0 25.0 23.1 22.7 18.6 20.5 19.8 23.5 22.8 15.4 21.7 25.0 24.7 29.4 26.5 26.9 23.7 21.7 24.3 23.7 20.6 26.5 20.7 19.9 28.1 22.0 22.1 22.3 20.1 Day 83 24.6 22.8 23.2 20.7 20.6 Day 84 19.4 20.2 19.5 23.5 21.9 22.3 18.0 29.8 24.6 26.0 24.9 19.9 27.2 22.3 18.6 24.9 18.9 27.4 22.3 2.3 Day 91 18.3 21.4 21.1 22.8 24.1 22.8 20.0 22.7 22.9 27.5 24.3 20.5 25.6 21.1 18.5 23.5 19.1 21.8 21.9 19.7 Day 99 Day 106 Day 112 Day 119 28.0 26.6 24.0 21.2 23.1 27.9 26.7 23.0 21.0 22.8 25.2 26.5 24.7 21.6 22.1 27.4 26.4 24.7 22.7 21.7 25.1 21.0 29.0 22.4 20.5 27.9 22.2 26.8 30.6 21.7 26.0 20.4 30.7 21.6 20.4 28.4 23.5 24.0 22.5 22.3 25.2 20.6 33.2 21.5 20.6 9.3 20.9 23.2 21.2 21.2 27.1 20.0 33.0 21.7 19.7 18.5 21.3 21.8 21.1 22.1 DuPont-4739 H90--2D46a1y6G: aSvuabgcehSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-4739 APPENDIX D INDIVIDUAL CLINICALAANNDDMOOPRHTTAHLAITLYMDOALTOAGICAL OBSERVATIONS 549 s|*anrSanHfeed. Doesmolcontain TSCA CBS H-24616: Subchroic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL ANDMOOPRHTTAHLAITLYMDQALTOAGICAL OBSERVATIONS AND EXPLANATORY NOTES Critical Dates Day 69 Male and female rats designated for reproduction evaluations were co-housed. Clinical observations collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 92 Female rats designated for the 90-day exposure period were sacrificed. Days 122 and 123 Male and female rats designated for the one-month recovery period were sacrificed, respectively. Day 182 Male and female rats designated for the 3-month recovery period were sacrificed. Any clinical sign observed on consecutive data collection days is assumed to have been present during the interim between observation days, and will be reported as having been observed over the period from the first-last day observed. Ophthalmology Evaluation observations and Clinical Pathology Evaluations are documented as Clinical Observations and interrupt the continuing clinical observations. All ophthalmology observations from test days 88 or 116 are those observed during the examination by the veterinary ophthalmologist. 550 CompanySanitized. Does notcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days MI 641149 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left 0-42,49-84,90-91 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MI 641155 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,'91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MI 641222 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MI 641214 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MX 641069 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MI 641070 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________________________________________________________DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation MI 641147 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design MI 641172 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Face, Left Sacrificed by design MI 641206 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left I No Ophthalmological Abnormalities Detected 1 Hair Loss, Forelimb, Bilateral Hair Loss, Side, Right Sacrificed by design MI 641094 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,90-91 44.91 88 91 0-42,49-70,90-91 44.91 88 77-84 91 0-14,90-91 44.91 88 21-42,49-84 56-84 91 0-42,49-84,90-91 44.91 88 91 TSCACBI 552  H90--2D4a6y16G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal MI 641098 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine. Left Days 0,7,14-35,42-56,106,119,126-182 36.78.90.106.120.133.154.175 Eye Observations, Bled via Orbital for blood fluorine, Right 1-4,10,21,57,93-99 Discharge, Nose, Black 77,84,91,99 MX 641066 Discharge, Eye right, Black Wound, Superficial, Nose Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left 63-77,84,91,99 112 182 0,7,14 21.36.78.90.106.120.133.154.175 I Eye Observations, Bled via Orbital for blood fluorine. Right Hair Loss, Forelimb, Right 1-4,10,57,93-99 175-182 Hair Loss, Forepaw, Bilateral 70-77,84,91,99-119,126-182 Hair Loss, Forepaw, Right 28-35,42-56,63 Wound, Superficial, Forepaw, Right 21 MI 641115 Sacrificed by design General observation, No Abnormality Detected 182 0,7,14-35,42-56,63-77,84 Eye Observations, Partially Closed, Left 175-182 Eye Observations, Enophthalmus, Left 126-182 Eye Observations, Exophthalmus, Left 91.99- 119 Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right 21,36,78,90,106 1-4,10,57,93-99,120,133,154,175 Eye Observations, Corneal Opacity, Left 99-119,126-182 Discharge, Eye left, Black 91.99- 119,126-140 Sacrificed by design 182 Doe*notcontato T8CA03 553 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal MI 641220 MI 641104 MI 641114 MI 641217 MI 641204 MI 641158 MI 641100 Observation Days General observation, No Abnormality Detected 0,7,14-35,42-56,63-77,84,91,99 Eye Observations, Enophthalmus, Right 106-119,126-147 Eye Observations, Bled via Orbital for blood fluorine, Bilateral 93 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154.175 Eye Observations, Bled via Orbital for blood fluorine, Right 1-4,10,57,99 Eye Observations, Corneal Opacity, Right 106-119,126-182 Sacrificed by design 182 General observation, No Abnormality Detected 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bled via Orbital for Clin Path, Left 21.36.78.90.106.120.133.154.175 Eye Observations, Bled via Orbital for Clin Path, Right 1-4,10,57,93-99 Sacrificed by design 182 General observation, No Abnormality Detected 0-14 Hair Loss, Forepaw, Bilateral 21-69 Removed from study 69 General observation, No Abnormality Detected 0-7,21-69 Vocalization 14 Removed from study 69 General observation, No Abnormality Detected 0-69 Removed from study 69 General observation, No Abnormality Detected 0-69 Removed from study 69 General observation, No Abnormality Detected 0-69 Removed from study 69 554 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days MI 641060 General observation, No Abnormality Detected 0-69 MI 641188 Removed from study General observation, No Abnormality Detected 69 0 Hair Loss, Forelimb, Bilateral 63-69 Hair Loss, Neck, Ventral 14-56 Wound, Superficial, Neck 7 MI 641106 Removed from study General observation, No Abnormality Detected 69 0-63 Wound, Deep, Tail 69 Removed from study 69 MI 641175 General observation, No Abnormality Detected 0-69 MI 641079 Removed from study General observation, No Abnormality Detected 69 0-69 MI 641125 Removed from study General observation, No Abnormality Detected 69 0-69 MX 641186 Removed from study General observation, No Abnormality Detected 69 0-69 MI 641052 Removed from study General observation. No Abnormality Detected 69 0-69 MI 641140 Removed from study General observation, No Abnormality Detected 69 0-69 MI 641135 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study- 69 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation MX 641174 General observation, No Abnormality Detected Removed from study MI 641107 General observation, No Abnormality Detected Removed from study MI 641072 General observation, No Abnormality Detected Removed from study HI 641053 General observation, No Abnormality Detected Removed from study MI 641168 General observation. No Abnormality Detected Removed from study MI 641084 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MX 641154 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Retina, Retinal Degeneration Focal, Left MI 641085 Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design HI 641105 General observation, No Abnormality Detected No' Ophthalmological Abnormalities Detected Sacrificed by design Days 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88 116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MATE RATS Sex Group Animal Observation MI 641215 General observation, No Abnormality Detected Hyperreactive No Ophthalmological Abnormalities Detected Sacrificed by design MI 641123 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected MI 641101 Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected MI 641165 Sacrificed by design General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 641083 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design MI 641159 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42 49-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 PS 3 1 4 UJ8JU0010U S80Q -pa^iuM g 557 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation M III 641146 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design M III 641218 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design M III 641073 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected M III 641056 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design M III 641178 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 H90--2D4a6y16G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days M III 641055 General observation, No Abnormality Detected 0-7,21-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Urine, Present 14 Sacrificed by design 91 M III 641144 General observation. No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 Retina, Retinal Degeneration Focal, Right 88 Sacrificed by design 91 M III 641198 General observation, No Abnormality Detected 0-42,49-84,90-91 1 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 r M III 641081 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left 0-42,49-84,90-91 44,91 I No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 1? M III 641224 General observation, No Abnormality Detected 0-42,49-84,90-91 i Eye Observations, Bled via Orbital for Clin Path, Left 44,91 a > No Ophthalmological Abnormalities Detected 88 i Sacrificed by design 91 559 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal M III 641194 Observation General observation, No Abnormality Detected M III M III M III Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Water nipple not working well Missed Water Sacrificed by design 641059 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design 641160 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right 641113 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design Days 0,7,14-35,42-56,63-77,84,91,99-119, 126-147,161-182 21,36,78,90,106,120,133,154,175 1-4,10,57,93-99 154 154 ' 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21,36,78,90,106,120,133,154,175 1-4,10,57,93-99 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21,36,78,90,106,120,133,154,175 1-4,10,57,93-99 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21,36,78,90,106,120,133,154,175 1-4,10,57,93-99 182 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days M III 641225 General observation, No Abnormality Detected 0,7,14 Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right 21,36,78,90,106,120,133,154,175 1-4,10,57,93-99 Hair Loss, Forelimb, Bilateral 140-182 Hair Loss, Forepaw, Bilateral 21-35,42-56,63-77,84,91,99-119,126-182 Hair Loss, Neck, Right 21-35,42-56,63-70 Sacrificed by design 182 M III 641087 General observation, No Abnormality Detected 0-69 Removed from study 69 M III 641108 General observation, No Abnormality Detected 0-69 Removed from study 69 M III 641118 General observation, No Abnormality Detected 0-69 M III 641128 Removed from study General observation, No Abnormality Detected 69 0-69 M III 641091 Removed from study General observation, No Abnormality Detected 69 0-69 M III 641199 Removed from study General observation, No Abnormality Detected 69 0-69 M III 641209 Removed from study General observation, No Abnormality Detected Hair Loss, Forepaw, Left 69 0-21,69 28-63 M III 641163 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 Doesnotcontain TSCACBl 561 .,, r.............. j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal M III 641129 Observation General observation, No Abnormality Detected Removed from study Days 0-69 69 M III M III M III M III M III M III M III M III M III 641138 General observation, No Abnormality Detected Removed from study 641103 General observation, No Abnormality Detected Removed from study 641181 General observation, No Abnormality Detected Removed from study 641171 General observation, No Abnormality Detected Removed from study 641111 General observation, No Abnormality Detected Hair Loss, Forelinib, Bilateral Hair Loss, Forelimb, Right Removed from study 641062 General observation. No Abnormality Detected Removed from study 641156 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Removed from study 641173 General observation, No Abnormality Detected Removed from study 641121 General observation, No Abnormality Detected Removed from study 0-69 69 0-69 69 0-69 69 0-69 69 0-14 49-69 21-42 69 0-69 69 0-63 69 69 0-69 69 0-69 69 Does notcontain TSCACBi 562 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________________________________________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal M III 641074 M III 641191 Observation General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study Days 0-69 69 0-69 69 TSCACB II 563 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal MV 641190 Observation General observation. No Abnormality Detected Days 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MV 641134 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MV 641202 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MV 641197 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 MV 641200 General observation. No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 MV 641061 Sacrificed by design General observation, No Abnormality Detected 91 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44,91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 Does not contain TSCACSi 564 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation MV 641162 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design MV 641089 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design MV 641137 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design MV 641102 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design MV 641076 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine. Right Sacrificed by design Days 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21,36,78,90,106,120,133,154 1-4,10,57,93-99,175 182 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days MV 641090 General observation, No Abnormality Detected 0,7,14 Eye Observations, Bledvia Orbital for blood fluorine. Bilateral 21 Eye Observations, Bledvia Orbital for blood fluorine, Left 36 Eye Observations, Bledvia Orbital for blood fluorine, Right 1-4,10 Hair Loss, Forelimb, Bilateral 21-35,42-51 Hair Loss, Forepaw, Bilateral 21-35,42-51 Hair Loss, Neck, Ventral 49-51 Wound, Superficial, Neck Wound, Deep, Neck 21-35,42-49 51 MV 641141 Sacrificed in extremis General observation, No Abnormality Detected 51 0,7,14,91,99 Eye Observations, Bled viaOrbitalfor blood fluorine, Left Eye Observations, Bled viaOrbitalfor blood fluorine, Right Discharge, Eye right, Black 21.36.78.90.106.120.133.154 1-4,10,57,93-99,175 63-77,84,168 MV 641187 Hair Loss, Forepaw, Right Sacrificed by design General observation, No Abnormality Detected 21-35,42-56,63-77,84,106-119,126-182 182 0,7,14-35,42-56,63-77,84,91,99-119, 126-182 Eye Observations, Bled viaOrbitalfor blood fluorine, Bilateral 10 Eye Observations, Bled viaOrbitalfor blood fluorine, Left 21.36.78.90.106.120.133.154 Eye Observations, Bled viaOrbitalfor blood fluorine. Right 1-4,57,93-99,175 Sacrificed by design 182 Doesnotcontain TSCACB 566 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation MV 641148 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design MV 641170 General observation, No Abnormality Detected Removed from study MV 641065 General observation, No Abnormality Detected Removed from study MV 641126 General observation, No Abnormality Detected Removed from study MV 641058 General observation, No Abnormality Detected Urine, Present Removed from study MV 641131 General observation, No Abnormality Detected Removed from study MV 641176 . General observation, No Abnormality Detected Removed from study MV 641119 General observation, No Abnormality Detected Removed from study MV 641075 General observation, No Abnormality Detected Urine, Present Removed from study Days 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21,36,78,90,106,120,133,154 1-4,10,57,93-99,175 182 0-69 69 0-69 69 0-69 69 0-7,21-69 14 69 0-69 69 0-69 69 0-69 69 0-7,21-69 14 69 is qsa U|iued|eu tsog 567 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days MV 641180 General observation, No Abnormality Detected 0-69 MV 641117 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 MV 641124 General observation, No Abnormality Detected 0-21 Hair Loss/ Forepaw, Left 28-69 MV 641082 Removed from study General observation, No Abnormality Detected 69 0-69 MV 641151 Removed from study General observation, No Abnormality Detected 69 0-69 MV 641195 Removed from study General observation, No Abnormality Detected 69 0-7 Hair Loss, Forelimb, Bilateral 14-69 Removed from study MV 641122 General observation, No Abnormality Detected Removed from study iI M V 641184 ' General observation, No Abnormality Detected Removed from study MV 641142 General observation, No Abnormality Detected 69 0-69 69 0-69 69 0-69 MV 641120 Removed from study General observation, No Abnormality Detected 69 0-69 MV 641179 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 TSCACB! 568 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days MV 641164 General observation, No Abnormality Detected 0-69 Removed from study 69 M VII 641201 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44.91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 M VII 641095 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44.91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 M VII 641223 General observation, No Abnormality Detected 0-21 Eye Observations, Bled via Orbital for Clin Path, Left 44.91 No Ophthalmological Abnormalities Detected 88 Hair Loss, Forepaw, Bilateral 28-42,49-84,90-91 Sacrificed by design 91 I M VII 641157 General observation, No Abnormality Detected 0-42,49-84,90-91 I Eye Observations, Bled via Orbital for Clin Path, Left 44.91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 M VII 641086 General observation, No Abnormality Detected 0-42,49-84,90-91 Eye Observations, Bled via Orbital for Clin Path, Left 44.91 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 91 fe*# 569 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________________________________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation M VII 641067 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design M VII 641097 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design M VII 641132 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected M VII 641166 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected M VII 641077 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 0-42,49-84,90-91 44,91 88 91 I**w 570 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal M VII 641130 Observation General observation, No Abnormality Detected Days 0,7,14-35,42 Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Discharge, Nose, Black 21.36.78.90.106.120.133.154 1-4,10,57,93-99,175 99 M VII 641057 Hair Loss, Forelimb, Left Sacrificed by design General observation, No Abnormality Detected 49-56,63-77,84,91,99-119,126-182 182 0,7,14-35,42-49,140-182 Eye Observations, Bled via Orbital for blood fluorine, Bilateral 57 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154 Eye Observations, Bled via Orbital for blood fluorine, Right 1-4,10,93-99,175 M VII 641205 Hair Loss, Forepaw, Bilateral Sacrificed by design General observation, No Abnormality Detected 56,63-77,84,91,99-119,126-133 182 0,7,14-35,42-56,70-77,84,91,99 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154 Eye Observations, Bled via Orbital for blood fluorine, Right 1-4,10,57,93-99,175 Discharge, Nose, Black 63 Discharge, Eye right, Black 112-119,140-182 Misshapen Observations, Tail 106-119,126-182 M VII 641196 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21.36.78.90.106.120.133.154 1-4,10,57,93-99,175 182 faniHzed. Doesnoteontrin TSCACil 571 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMQLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation M VII 641169 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design M VII 641110 General observation. No Abnormality Detected Vocalization Removed from study M VII 641096 General observation, No Abnormality Detected Compound evident on lips during dosing Removed from study M VII 641212 General observation, No Abnormality Detected Removed from study M VII 641068 General observation, No Abnormality Detected Removed from study M VII 641093 General observation, No Abnormality Detected M VII 641054 Removed from study General observation, No Abnormality Detected M VII 641208 Removed from study General observation, No Abnormality Detected Removed from study Days 0,7,14-21,77,84,91,99-119,126 21,36,78,90,106,120,133,154 1-4,10,57,93-99,175 28-35,42-56,63-70 140-182 133 182 0-7,21-69 14 69 0-63,69 67 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 Sanitized Does notcontain TSCACBl 572 CompanySanitized. Does notcontain TSCACBl ) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days M VII 641193 General observation, No Abnormality Detected 0-14 Hair Loss, Forelimb, Bilateral 21-69 M VII 641207 Removed from study General observation, No Abnormality Detected 69 0-14 Hair Loss, Forepaw, Bilateral 21-69 M VII 641139 Removed from study General observation, No Abnormality Detected 69 ' 0-69 Removed from study 69 M VII 641080 General observation, No Abnormality Detected 0-69 Removed from study 69 M VII 641078 General observation, No Abnormality Detected 0-69 Removed from study 69 M VII 641177 General observation, No Abnormality Detected 0-69 Removed from study 69 M VII 641112 General observation, No Abnormality Detected 0-69 M VII 641210 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 M VII 641152 General observation, No Abnormality Detected 0-69 M VII 641182 Removed from study General observation. No Abnormality Detected 69 0-69 M VII 641150 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 573 'w' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________________________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal Observation Days M VII 641211 General observation, No Abnormality Detected 0-69 Removed from study 69 M VII 641145 General observation, No Abnormality Detected 0-14 Hair Loss, Forepaw, Bilateral 49-69 Wound, Superficial, Lumbar 21-63 Wound, Superficial, Neck 21-49 Removed from study 69 M VII 641185 General observation, No Abnormality Detected 7-84,91-112,119-122 No Ophthalmological Abnormalities Detected 88,116 Feces, Present 0 Sacrificed by design 122 M VII 641064 General observation, No Abnormality Detected 0-84,91-112,119-122 No Ophthalmological Abnormalities Detected 88,116 Sacrificed by design 122 M VII 641216 General observation, No Abnormality Detected 0-84,91-112,119-122 No Ophthalmological Abnormalities Detected 88,116 Sacrificed by design 122 M VII 641092 General observation, No Abnormality Detected 0-84,91-112,119-122 No Ophthalmological Abnormalities Detected 88,116 Sacrificed by design 122 CompanySanitized. Does notcontain TSCACB 574 H90--2D46a1y6G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR MALE RATS Sex Group Animal M VII 641167 Observation General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Retina, Retinal Degeneration Focal, Left Sacrificed by design Days 0-84,91-112,119-122 88 116 122 M VII M VII M VII 641189 General observation, No Abnormality Detected General Teeth Observations, Absent No Ophthalmological Abnormalities Detected Sacrificed by design 641213 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 641153 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 0-84 85,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 0-84,91-112,119-122 88,116 122 M VII 641203 General observation, No Abnormality Detected Hyperreactive Breathing Observations, Noise No Ophthalmological Abnormalities Detected 0-70,77 99-112,119-122 84,91-112 88,116 M VII 641143 Compound evident on animal's lips Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 74 122 0-14,77-84,91-112,119-122 88,116 21-70 122 Oses nocontain TSCACBl 575 ! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F II 641257 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected 44.92 88 Sacrificed by design 92 F II 641290 General observation, No Abnormality Detected 0-42,49,77 Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral 44.92 88 56-70,84,91-92 F II 641283 Sacrificed by design General observation, No Abnormality Detected 92 0-14 Eye Observations, Bled via Orbital for Clin Path, Left 44.92 So Ophthalmological Abnormalities Detected 88 Hair Loss, Forelimb, Bilateral 21-42,49-84,91-92 F II F II 641344 641384 Hair Loss, Lumbar, Dorsal Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 21-42,49-84,91 92 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 Does notcontain TSCACBJ 576 not contain TfOAcsl I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F II 641293 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44.92 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 92 F XI F II 641249 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Right Accidentally killed 641245 General observation, No Abnormality Detected 0-42,49-56,77-84,91-92 44.92 88 63-70 92 0-14 F II F II Eye Observations, Bled via Orbital for Clin Path, Left Nb Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb,. Right Sacrificed by design 641240 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 641335 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design 44.92 88 49-84,91-92 21-42 92 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 577 ! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations I DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F II 641309 General observation, No Abnormality Detected 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bled viaOrbitalfor blood fluorine, Left Eye Observations, Bled viaOrbitalfor blood fluorine, Right 21.36.57.78.90.106.120.133.154.175 4.10.93-99 Sacrificed by design 182 II 641285 General observation, No Abnormality Detected 0,7,14-35,42-56,63-70 Eye Observations, Bled viaOrbitalfor blood fluorine, Left 21',36,57,78,90,106,120,133,154,175 Eye Observations, Bled viaOrbitalfor blood fluorine, Right 4.10.93- 99 Discharge, Eye right, Black 77,84,91,99-119,161-168 Hair Loss, Forepaw, Bilateral 106-119,126-182 Sacrificed by design II 641241 General observation, No Abnormality Detected 182 0,7,14-35,42-56,63-77,84,91,99-119, 126-161,175-182 Eye Observations, Bled viaOrbitalfor blood fluorine, Left 21.36.57.78.90.106.120.133.154.175 Eye Observations, Bled viaOrbitalfor blood fluorine, Right 4.10.93- 99 Discharge, Eye left, Black 168 Sacrificed by design II 641288 General observation, No Abnormality Detected 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bled via Orbital for blood fluorine, Bilateral 10 Eye Observations, Bled via Orbital for blood fluorine, Left 21,36,78,90,106,120,133,154,175 Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design 4,57,93-99 182 tsca cb 578 I Does no!contain TSCACB / '3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLQGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F II 641394 General observation, No Abnormality Detected 0,7,14-35,42-56,161-182 Eye Observations, Bled viaOrbital for blood fluorine, Bilateral 10,57 Eye Observations, Bled viaOrbital for blood fluorine, Left 21,36,78,90,106,120,133,154,175 Eye Observations, Bled viaOrbital for blood fluorine, Right 4,93-99 Discharge, Eye left, Black 147-154 Hair Loss, Side, Right 140 Wound, Superficial, Side, Right 99-119,126-133 Mass Side, Right, Mass #1, Not Ulcerated 63-77,84,91 Sacrificed by design 182 F II 641345 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641236 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641337 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641328 General observation, No Abnormality Detected 0-69 F II 641310 Removed from study General observation, No Abnormality Detected 69 0-69 F II 641324 Removed from study General observation, No Abnormality Detected 69 0-69 F II 641371 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 579 ! i / ^) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F II 641332 General observation, No Abnormality Detected 0-56 Hair Loss, Forelimb, Bilateral 63-69 F II 641358 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 F II 641389 General observation, No Abnormality Detected 0-56 Hair Loss, Forelimb, Bilateral 63-69 Hair Loss, Hindlimb, Bilateral 63-69 Removed from study 69 F II 641317 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641255 General observation, No Abnormality Detected 0-28 Hair Loss, Forepaw, Bilateral 35-69 Removed from study 69 F II 641403 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641388 General observation, No Abnormality Detected 0-69 Removed from study 69 F II 641261 General observation, No Abnormality Detected 0-69 F II 641306 Removed from study General observation, No Abnormality Detected 69 0-69 F II 641349 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 Des notcontain TSCACBI 580 J H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS f f 3 Sex Group Animal Observation F II 641346 General observation, No Abnormality Detected F II 641308 Removed from study General observation, No Abnormality Detected Removed from study F II 641289 General observation, No Abnormality Detected Removed from study F II 641253 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F II 641359 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F II 641325 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F II 641281 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-69 69 0-69 69 0-69 69 0-84,91-112,119-123 123 88,116 123 0-84,91-112,119-123 123 88,116 123 0-84,91-112,119-123 123 88,116 123 0-84,91-112,119-123 123 88,116 123 (tuVOSJ. 581 H90--2D46a1y6G: aSvuabgechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F II 641294 Observation General observation, No Abnormality Detected Days 0-84,91-112,119-123 Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected 123 88,116 Sacrificed by design 123 F II 641383 General observation, No Abnormality Detected 0-84,91-112,119-123 Eye Observations, Bled via Orbital for Clin Path, Left 123 No Ophthalmological Abnormalities Detected 88,116 F II 641364 Sacrificed by design General observation. No Abnormality Detected 123 0-84,91-112,119-123 Eye Observations, Bled via Orbital for Clin Path, Left 123 No Ophthalmological Abnormalities Detected 88,116 Sacrificed by design 123 F II 641331 General observation, No Abnormality Detected 0-84,91-112,119-123 Eye Observations, Bled via Orbital for Clin Path, Left 123 No Ophthalmological Abnormalities Detected 88,116 Sacrificed by design 123 F II 641400 General observation, No Abnormality Detected 0-84,91-112,119-123 Eye Observations, Bled via Orbital for Clin Path, Left 123 No Ophthalmological Abnormalities Detected 88,116 F II 641266 Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected 123 0-84,91-112,119-123 123 88,116 Sacrificed by design 123 TSCArwl 582 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F IV 641396 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F IV 641369 Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F IV 641336 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F IV 641355 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F IV 641260 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F IV 641312 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Sacrificed by design F IV 641313 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F IV 641311 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F IV 641298 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Discharge, Nose, Black Discharge, Eye right, Black No Ophthalmological Abnormalities Detected Sacrificed by design F IV 641361 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-28 44.92 88 35-42,49-84,91-92 92 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 0-42,49-77 44.92 84.91 92 88 92 0-42,49-84,91-92 44.92 88 92 CompanySanitized, Does notcontain TSCAOil H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F IV 641321 General observation, No Abnormality Detected 0,7,14-35,42-56,70-77,84,91,99-119,126-182 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154.175 Eye Observations, Bled via Orbital for blood fluorine, Right 4,10,57,93-99 Discharge, Eye right, Black 63 Sacrificed by design 182 F IV 641391 General observation, No Abnormality Detected 0,7,14-35,77,84,91 Eye Observations, Partially Closed, Bilateral 168-182 Eye Observations, Enophthalmus, Bilateral 140-182 Eye Observations, Enophthalmus, Right 119,126-133 Eye Observations, Exophthalmus, Left 99-112,126-133 Eye Observations, Bled via Orbital for blood fluorine, Bilateral 93 Eye Observations, Bled via Orbital for blood fluorine, Left 21,36,78,90,99-106,120 Eye Observations, Bled via Orbital for blood fluorine, Right 4,10,57 Eye Observations, Corneal Opacity, Bilateral 154-182 Eye Observations, Corneal Opacity, Right 106-119,126-147 Discharge, Eye right, Black Hair Loss, Forepaw, Bilateral Hair Loss, Face, Right Fluorine bleed not done 99-119,126-133 42-56,63-70 106-119,126-140 133 Bled by tail vein Sacrificed by design 154.175 182 585 r H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Doesnotcontain TSCACB Sex Group Animal F IV 641340 Observation General observation, No Abnormality Detected Days 0,7,14-35,42-56,63-77,84,91,99, 112-119,126-182 Eye Observations, Bled via Orbital for blood fluorine, Bilateral 133 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.154.175 Eye Observations, Bled via Orbital for blood fluorine, Right 4.10.57.93- 99 Discharge, Eye left, Black 106 Sacrificed by design IV 641247 General observation, No Abnormality Detected 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154.175 Eye Observations, Bled via Orbital for blood fluorine. Right 4.10.57.93- 99 Sacrificed by design IV 641319 General observation, No Abnormality Detected 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bled via Orbital for blood fluorine, Left 21.36.78.90.106.120.133.154.175 Eye Observations,Bled via Orbital for blood fluorine, Right Sacrificed by design IV 641378 General observation, No Abnormality Detected Removed from study IV 641263 General observation, No Abnormality Detected 4.10.57.93-99 182 0-69 69 0-49 Hair Loss, Forelimb, Bilateral 56-69 Removed from study IV 641297 General observation, No Abnormality Detected Removed from study IV 641304 General observation, No Abnormality Detected 69 0-69 69 0-69 Removed from study 69 586 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________________________________________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F IV 641274 General observation, No Abnormality Detected 0-69 Removed from study 69 F IV 641351 General observation, No Abnormality Detected 0-69 Removed from study 69 F IV 641272 General observation, No Abnormality Detected 0-7 Hair Loss, Forelimb, Bilateral 14-69 Hair Loss, Forepaw, Bilateral 35-69 Removed from study 69 F IV 641258 General observation, No Abnormality Detected 0-69 Removed from study 69 F F IV 641276 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Removed from study i F IV 641350 General observation, No Abnormality Detected Removed from study F IV 641376 General observation, No Abnormality Detected 0-14 21-69 69 0-69 69 0-69 F IV 641315 Removed from study General observation, No Abnormality Detected 69 0-14 Misshapen Observations, Ear, Left 21-69 F IV 641286 Removed from study General observation, No Abnormality Detected 69 0-69 F IV 641231 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 tsca ce 587 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations______________________________________________________________DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F XV 641338 General observation, No Abnormality Detected Removed from study F IV 641318 General observation, No Abnormality Detected Removed from study F IV 641373 General observation, No Abnormality Detected Hair Loss, Abdomen, Bilateral Hair Loss, Base of tail Hair Loss, Forelimb, Bilateral Hair Loss, Hindlimb, Bilateral Removed from study F IV 641365 General observation. No Abnormality Detected Removed from study F IV 641348 General observation, No Abnormality Detected I Hair Loss, Forelimb, Bilateral i Removed from study F IV 641323 General observation, No Abnormality Detected Removed from study Days 0-69 69 0-69 69 0-14 42-69 42-69 21-69 42-69 69 0-69 69 0-28 35-69 69 0-69 69 tscacb 588 Does notcontain TSCACBI I H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F VI 641398 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 92 F VI 641251 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 92 F VI 641292 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 F VI 641269 Sacrificed by design General observation, No Abnormality Detected 92 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 F VI 641379 Sacrificed by design General observation, No Abnormality Detected 92 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 92 F VI 641302 General observation, No Abnormality Detected 0-42,49-84,91-92 Eye Observations, Bled via Orbital for Clin Path, Left 44,92 No Ophthalmological Abnormalities Detected 88 Sacrificed by design 92 589 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND QPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F VI 641244 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VI 641362 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VI 641363 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VI 641375 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F VI 641382 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for blood fluorine, Left Eye Observations, Bled via Orbital for blood fluorine, Right Sacrificed by design Days 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 0-42,49-84,91-92 44.92 88 92 0,7,14-35,42-56,63-77,84,91,99,140-182 106-119,126-133 21,36,78,90,106,120,133,154 4,10,57,93-99,175 182 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F VI 641262 General observation, No Abnormality Detected 0,7,14-35,42-56,63-70,91,99-119 Eye Observations, Partially Closed, Left 168-182 Eye Observations, Enophthalmus, Left 140-182 Eye Observations, Exophthalmus, Left 126-133 F VI F VI Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Discharge, Eye left, Black Hair Loss, Forepaw, Bilateral Hair Loss, Face, Left Sacrificed by design 641232 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Discharge, Eye right, Black Hair Loss, Face, Right Sacrificed by design 641305 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Hair Loss, Forelimb, Right Wound, Superficial, Forelimb, Right Sacrificed by design 21,36,78,90,106,120 4.10.57.93- 99,133,154,175 126-133 77,84 133-140 182 0,7,35,42-56,63-77,84,91,99-119,126-182 21.36.78.90.106.120.133.154 4.10.57.93- 99,175 14 21-28 182 0,7,14-35,42 21.36.78.90.106.120.133.154 4.10.57.93-99,175 56,63-77,84,91,99-119,126-182 49-56,63-77,84,91,99-119,126-133 182 notcontain TSCArtf 591 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation Days F VI 641372 General observation, No Abnormality Detected 0,7,14-35,42-56,63-77,84,91,99-119,126-182 Eye Observations, Bledvia Orbital for blood fluorine, Bilateral 175 Eye Observations, Bledvia Orbital for blood fluorine, Left 21,36,78,90,106,120,133,154 Eye Observations, Bledvia Orbital for blood fluorine, Right 4,10,57,93-99 F VI 641271 Sacrificed by design General observation, No Abnormality Detected 182 0-69 F VI 641280 Removed from study General observation, No Abnormality Detected 69 0-69 F VI 641252 Removed from study General observation. No Abnormality Detected 69 0-69 F VI 641386 Removed from study General observation, No Abnormality Detected 69 0-69 Removed from study 69 F VI 641277 General observation, No Abnormality Detected 0-69 Removed from study 69 F VI 641233- General observation, No Abnormality Detected 0-14 Hair Loss, Forelimb, Bilateral 21-69 Removed from study 69 F VI 641238 General observation, No Abnormality Detected 0-69 Removed from study 69 F VI 641235 General observation, No Abnormality Detected Removed from study 0-69 69 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations______________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F VI 641392 General observation, No Abnormality Detected F VI 641360 Removed from study General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral F VI 641381 Removed from study General observation, No Abnormality Detected F VI 641333 Removed from study General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral F VI 641239 Removed from study General observation, No Abnormality Detected r F VI F VI 641228 641334 Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected F VI 641347 Removed from study General observation, No Abnormality Detected Removed from study F VI 641367 General observation, No Abnormality Detected Removed from study F VI 641303 General observation, No Abnormality Detected Removed from study Days 0-69 69 0-28 35-69 69 0-69 69 0-14 21-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 Isaa tfySi ttieiuoojou 593 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F VI 641339 F VI 641316 Observation General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study Days 0-69 69 0-69 69 Does oofcontain TSCACBI 594 Does notcontain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND QPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F VIII 641299 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641275 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F VIII 641326 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Breathing Observations, Noise No Ophthalmological Abnormalities Detected F VIII 641380 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F VIII 641314 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 0-42,49-70,84,91-92 44,92 77 88 92 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 595 ! ; H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F VIII 641237 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641300 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641279 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Wound, Superficial, Neck Sacrificed by design F VIII 641390 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641327 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 0,21-42,49-84,91-92 44,92 88 7-14 92 0-42,49-84,91-92 44,92 88 92 0-42,49-84,91-92 44,92 88 92 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F VIII 641259 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Sacrificed by design F VIII 641264 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Eye Observations, Corneal Opacity, Left Hair Loss, Forelimb, Right Hair Loss, Forepaw, Right Sacrificed by design F VIII 641301 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Sacrificed by design F VIII 641395 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for blood fluorine, Left Eye Observations, Bledvia Orbital for blood fluorine, Right Sacrificed by design Days 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21.36.78.90.106.120.133.154 4.10.57.93- 99,175 182 0,7,-14-35,42-56,63-70,147-154 21.36.78.90.106.120.133.154 4.10.57.93161-182 99,175 140 77,84,91,99-119,126-140 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21.36.78.90.106.120.133.154 4.10.57.93- 99,175 182 0,7,14-35,42-56,63-77,84,91,99-119,126-182 21.36.78.90.106.120.133.154 4.10.57.93- 99,175 182 TSCA CB! 597 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Gneration Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F VIII 641278 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for blood fluorine, Left Days 0,7,21-35,42-56,63-77,84,91,99,147-182 21,36,78,90,106,120,133,154 Eye Observations, Bled via Orbital for blood fluorine, Right 4,10,57,93-99,175 Hair Loss, Forelimb, Bilateral 106-119,126-140 Urine, Present Sacrificed by design 14 182' F VIII 641265 General observation, No Abnormality Detected 0-69 Removed from study 69 F VIII 641393 General observation, No Abnormality Detected 0-69 Removed from study 69 F VIII 641402 General observation, No Abnormality Detected 0-69 Removed from study 69 F VIII 641246 General observation, No Abnormality Detected 0-14 Hair Loss, Forelimb, Bilateral 28-69 Hair Loss, Forelimb, Left 21 Removed from study 69 F VIII 641320 General observation, No Abnormality Detected 0-14,56-69 Hair Loss, Forelimb, Bilateral 21-49 Removed from study 69 F VIII 641353 General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral 0-14 21-69 Removed from study 69 F VIII 641401 General observation, No Abnormality Detected 0-69 Removed from study 69 Sanitized. Doesnotcontain TSCACBI 598 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal F VIII 641307 Observation General observation, No Abnormality Detected Removed from study F VIII 641368 General observation, No Abnormality Detected Removed from study F VIII 641343 General observation, No Abnormality Detected Removed from study F VIII 641254 General observation, No Abnormality Detected Removed from study F VIII 641242 General observation, No Abnormality Detected Removed from study F VIII 641284 General observation, No Abnormality Detected Removed from study F VIII 641230 General observation, No Abnormality Detected Removed from study F VIII 641273. General observation, NO Abnormality Detected Removed from study F VIII 641296 General observation. No Abnormality Detected Removed from study F VIII 641248 General observation, NO Abnormality Detected Removed from study F VIII 641370 General observation, No Abnormality Detected Removed from study Days 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 0-69 69 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________ DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLQGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS I Sex Group Animal F VIII 641243 Observation General observation, No Abnormality Detected Hair Loss, Forelimb, Bilateral F VIII 641329 Removed from study General observation, No Abnormality Detected Hair Loss, Forelimb, Left Wound, Superficial, Forelimb, Left F VIII 641385 Removed from study General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Sacrificed by design F VIII 641387 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641282 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design Days 0-14 21-69 69 0-49 56-69 63 69 0-14 123 88,116 21-84,91-112,119-123 123 0-84,91-112,119-123 123 88,116 123 0-21 123 88,116 28-84,91-112,119-123 123 Boss notcontain tsca 600 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F VIII 641234 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design F VIII 641256 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641356 General observation, No Abnormality Detected Discharge, Eye bilateral. Black Discharge, Nose, Black No Ophthalmological Abnormalities Detected Abnormal Gait, Hindlimb, Bilateral, Mild Found dead in cage. F VIII 641352 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Sacrificed by design Days 0-14 123 88,116 21-84,91-112,119-123 77-84,91-112,119-123 123 0-84,91-112,119-123 123 88,116 123 0-84,91-106 112,119-121 112,119-121 88,116 119-121 121 0-14 123 88,116 21-84,91-112,119-123 123 601 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA FOR FEMALE RATS Sex Group Animal Observation F VIII 641366 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 641399 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected F VIII 641377 Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-84,91-112,119-123 123 88,116 123 0-84,91-112,119-123 123 88,116 123 0-84,91-112,119-123 123 88,116 123 Does notcontain TSCACOf 602 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-4739 APPENDIX E OPHTHALMOLOGICAL EXAMINATION REPORTS 603 Company Sanitized. Does not contain TSCA CBll H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLOGICAL EXAMINATION REPORTS ABBREVIATIONS: OODS -- lreigfthetyeeye EXPLANATORY NOTES DuPont-4739 NOTES: Oabnnloyramnaimlitaielss wdeitthecotepdh.thalmological findings were reported. All other animals had no 604 Company CBSSanitized. Does not contain TSCA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLOG(TIECSATLDEAXYAM88I)NATION REPORT DuPont-4739 NANCY M . BROMBERG, V.M .D., M .S. EYE CLINIC FOR ANIMALS 6119 MASSACHUSETTS AVE BETHESDA, MD 20816 STUDY INFORMATION: Study H#: 2461 Species: Rat Stndy Director: Don Delkcr OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: December 15,2000 METHODS: Indirect Ophthalmoscopy following 1% Tropicamide mydriasis Sex G roup# Anim al# O b servation M ale in 641144 Focal retinal degeneration OD C O M M EN TS/D ISC U SSIO N One (1) male animalwas identified with focal retinal degeneration, considered to be an incidental finding. All other animals had no visible ophthalmoscopic lesions. D a te 605 Com paiiy Sanitized. Does not contain H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLO(GTIECSATLDEAXYA1M16IN) ATION REPORT DuPont-4739 NANCY M . BROMBERG, VJMJ>,,, M .S. EYE CLINIC FOR ANIMALS 611B9EMTAHSESSADCAH,UMSDET2T08S1A6VE STUDY INFORMATION: Study H#2461i Sped: Rat Study Director: Don Delker OPHTHALMOLOGICAL EXAMINATION SUMMARY Examination Date: January 12,2001 Test Day: 116 METHODS: Indited Ophthalmoscopy following 1% Tropicainidc mydriasis Sex Animal # Observation M ale 641154 Focal retinal degeneration OS 641167 Focal retina! degeneration OS C O M M EN TS/D ISC U SSIO N Two (2) males were identified with focal retinal degeneration, considered to be an incidental finding. All other animals examined had no visible ophthalmoscopic lesions. No compound related abnormalities were ideotilled. 606 Company Sanitized, Dees not ennf ve Mgft