Document Vj2pxrnEDx9aK3NbVR7Xv5ab8

15:52 85/ZG/98 lo:SI:J:lZ Via Fax -> 216 SBG 8314 D. STROTHER Page EIBl VIA FAX TO: STROTHER,- DALE E. BP AMERI!:A FROM: ATTN: DALE STROTHER TO: FAX PHONE#: 216-586-8314 Job Number: 32909604-009-5-0000 TIME: Thu May 28 16: 49: 34 1998 7 pages including cover sheet BP-00011652 15:52 -95/ZB/98 tfi:so:za Via-Pd~ \ MAY-28-1998 14:47 FROM -> 216 SBG 8314 D. STROTHER API-HESD-WRSHINGTON DC TO Xped i teo Fage BHZ P.02 American Petroleum Institute 1220l Street. Norti!WKt Washington, oc 20005-4010 202-6112-8DOI) TO: Benzene Conference Workgroup FROM: Patrick Beatty (510.) 242-7037 CeCe Sharp (202) 682-8333 DATE: May 28,1998 RE: Conference Call- June 3 or 5 We would like to schedule a conference call next week to finalize our proposed agenda for the Workshop and come up with our list of recommended speakers. These recommendations will then be given to the uadvisory committeeD discussed on our last conference call as their basis for finalizing the agenda. As things are shaping up, it appears that the advisory committee will be Dan Krewski, Bob Snyder, Betty Meeks (Health canada), Pat Beatty, someone from Bob Farland's office, and someone from CPPI (either Roger Keefe or Geoff Granville), as well as Jonathon Frisch and CeCe Sharp from API. Attached for your review are the following: - One page description (DRAFT) of tt:le purpose of the workshop - Draft agenda {used for discussion on our first conference call) - Draft list of proposed attendees Please..Jook these over and we will try to finalize our proposed agenda on a call next week. PLEASE COMPLETE THE ATTACHED CONFERENCE CALL RESPONSE FORM AND FAX IT TO ELSIE BARBAZA-NO LATER THA:N FRIDAY, MAY 29. (FAX- 202-682-8270) cc: D. Mongillo J. Frisch An equal oppollllnl!y empk!yof BP-00011653 15:53 BS/2B/9B 16:58:56 Vid-Fax MAY-28-1998 14:47 FROM -> Zlb 5Bb 8314 D. STRDfHER API-HESD-WASHINGTON DC TO Xpedite Filge EIH3 P.03 Ben.z:ene Conferen~e Workgroup Memo - May 28, 1998 Page2 BENZENE CONFERENCE WORKGR0UP CONFERENCE CALL RESPONSE FORM NAMEd /t/_ T '"[/,(' c TIfF!C. ( AVAILABILITY FOR CONFERENCE CALL Wednesday, June 3 9:00AM EST YEs__~x--.--- - NO_________ Friday, June 5 9:00AM EST YES________ NO__~~------_ PLEASE COMPLETE THE ABOVE AND FAX IT TO ELSIE BARBAZA NO LATER THAN FRIDAY. MAY 29. FAX- (20Z) 682-8270 BP-00011654 15;53 85/28/98 1~:s1:1~ Vid Fdx ~> 21~ SB~ 8314 D. STROTHER MRY~28~1998 14'48 FROM- DCRPI-HESD~WRSHINGTON TO Xpedite P.age 884 P.04 DRAFT Benzene State of the Science Workshop Meeting proposed for October 1998 University of Ottawa. Institute of Population Health The purposes of the proposed workshop are two-fold: to review the current state of knowledge about benzene toxicity to identify data gaps and areas where further research would contribute meaningf-~;~lly to scientific understanding of the mechanism and extent of ben.-:ene's human toxicity To accomplish these goals. a group of promi-nent researchers, as well as representatives of government agen~;ie~-and industry, would be invited to participate in a 2 day meeting. which is env-isioned to include both plenary presentations on the state of the science and focused discussions on specific issues in benzene toxicity. While the agenda for the meeting will be established by the meeting host and sponsors, specific topic areas-t-hat have been discus~ed a:o-potential subjects for discussion include: benzene's mechanism of leukemogenesis (with special emphasis on relevant mechanisms of genotoxicity) the appropri-ate leukemia cell type for assessing benzene leukemia risk the significance of the NCI epidemiologic study of benzene workers in China what can be learned about benzene risk from other known secondary leukemogens A one-day "satellite" meeting has also been discussed, to occur either before or after the main workshop-;- at which Tony Cox's mathematical simulation model for hematotoxici1y would be discussed by a peer review panel of modelers, toxicologists and hematologists_ The workshop-\.vould serve as a stepping stone in the continuing evolution of the understanding of benzene, and is intendedio poteRt-ially lay the groundwork for a future, larger meeting at which state of the art sc~ent1fic research could be presented in a more comprehensive manner (similar to Ben.-:ene 95). BP-00011655 15:54 85/28/98 16:51:47 Via Fax \ MRY-28-1998 14=48 FROM -> Z16 58, 8314 D. STRO.THER RPI-HESD-WASHINGTON DC TO Xpedite Pilge 885 P.05 20min. 20min. 20rnin. each break (continue) 20min. break 20min. 40rnin. Agenda for Half-Day BORA P~r-Review Introduction Overview Comments from Peer-reviewers Carol Honey Tony Cox Frederic Bois Chow Chen Kenny Crump Suresh Moolgavlcar Chris Portier Questions and Comments Concerning Structure of the Model Moderator: Julian Preston Validation and Application ofthe Model Group Discussion Rich Irons Moderator: John Graham Agenda for Full-Day Resea.-ch Directions l. Laboratory Efforts Metabolism Rogenc Het~denon Genotoxicity Gary Williams Mechanism-of Hematotoxicity and Leukemogenesis Rich Irons Other Adverse Health Outcomes U. Field Efforts and Epidemiology Further insights from Pliofilm Cohort Paul Price NIH Chinese Epidemiology Study Otto Wong HEl Biomarker Work in China Martha Richmond III. Future Directions Perceived Needs for Modification of Regulation Bob Sonawane Gre>up Discus~<ion Moderator: Febuary 3, 1998 BP-00011656 15:54 ' 85L28/9B 16:52:18 Via Fax . MAY-28-1998 14=48 FROM -> 216 586 8314 D. STROTHER API-HESD-WRSHINGTON DC TO Xpedite Page 886 P.06 Bnr:sne Canferenee Atcndees 5/28198 Ora.naation ~. .tName American ~.e.a_IJh l"oundation lor. Jo'"'-. ~r:ne.~iean Health l'oundation G_a_ry Applid Healttl Sej_enea ~-~cr CIIT lt!J_,_ - Cox AaRocaates Otto __ :Julian Mel Michel_l_e Anthony Fr9d HU1chi~_o_n Re~:earch C Dr. Suresh ~~ci-~\"1~8 I~F Kaiser Dr. D~.r:l - Kenny Lovelace 8.e.s,pitory Rasearc; Dr. Rooene.. !i!'-ti_2n!!l Cancer lnstirute RJ.!'~ard ~_gl_l_':'~)~tute Envifonom Or. <;_f:lria t:'.utge:re University ~!-_Bob U of C..l a~ Berklel[ F'redl:'ric: Univaroitv ?1 _Cal at River~id Dr. Da~d ~a,;ixe.rt.i_nl .of Cal.et Berklev 12.t-_Martvn Umvsreitv of C'!)_i_f_o.r.:lla at Be Dr. Robert U_niver'$il)! of Colorado Heal_t Dr. Rich US E.P.A. Or. U_S-EPA Dr. W.llia"' US EPA. Dr. B<>b USEPA Health and Environm Chao L8et Name Whv.ner William Wong-- Pre~t~_n ~':'da...,on Medinakv Cox ~oaa\lksr Krewski Kn,~_rr,p Henderson Have8 Ponier ~- Snvd.II.L ~~is l;aetrnond Smith Spear lrOIJ,S____ ~e-~on r:.a.r!and Sonawane Chen .. .. Aclcl.-c , 1 Oans Rd Acklr 2 , Dana Ret _ 181 2nd Ava. Suit B o..,;. Or, P.O. ll.ox 121_37 6 DM.Ii~ Dr B Davis Dr. - 50" r:ranklin St. 1 124 Columbia.St . -- Health Protection soz E. G~_or~ia Av Kitt1and AF8 East P.O.Box 3850 9000 Roc:lc;vill~ Pik 1 1 1 TW Ale"'"!::dc IT<>xicoloa'(. 1_7() F'r UIJ_i_vcrsity of Calif - EIWiron. Tox. Prog School of Public H Sehool of Public H ti2oo E. 9t_f:l Aye j 401 11,11. St.SW #8 401 M St SW #85 401 M St. SW-#8 401 M. St S.W. II cttv. St~te ---Val-Halla Valhalla S,an Msto NY NY - CA ...... Re11earch]'~a NC Researeh_ Tria ~c Research Tria NC____ Denver ...... co Seattle WA Tun~va Past Otto~~~ta_ ---Ru11ton LA IA.r.bar(lurque ~M .... 81:-theecla Research Tria M~-D~;-. NJ-~ PilleOtiiWIIV .. Be"-'.e.Y CA Riveraicle BarkelvBe~fs.ely CA --.~ c~ r-A Denver Mlaahinaton occ~- WS8hinaton- __ DC ML8CI:Ii."at""- oc w-hinaton DC Page 1 BP-00011657 -05/28/98 15:55 85128/98 16:52:39 Yia Fdx MAY-28-1998 1a:49 FROM -> 216 506 0314 D. STROTHER RPI-HESD-WASHINGTON DC TO Xpedite Pa!Je 887 P.07 Berntene Conforenc" Atendees 5128198 P_,. code 1_059L 10595 94401 27..?.0~ .27709 127709 8~~18 98104 KIA OL2. 71270 87115 20892 27709 lo88S4 ls.4720__ 92521 94720-7360 9.~ 7 20:'73'60 80~132 ~q4150___ 20460 ~o4ao ... - 20480 T 914789 7137 fx -- -~- 919 558 1387 919 615Jj_1_3_09 919 547 1723 - ... !!ij_9_5_58 1250 919 641 9015 303 388 1778 303 54_1_6_0.!)_3 206 S87 4~73 206 637 1978 &13 941 6082 ~-J..8..2,4~ 5019 318 2156 4960 505 846,164 505 8~_5_1198 301 496 ~00 301 496 9093 919 5_4._1 4999 919 641 1479 732 445 0210 . 610 642 4248 -. 510 1?~2 5815 909 787 ~7 51_0_~2 8770 510 642 0761 510 G42 5916 303_3_1!;; 7196 919 541 0043 2.02 664 3322 - -- 2.~?. 585 0090 Z02 &643298 202 565 0078 202 564-3279-. 202 665 0079 ...... .. . -- - andersontiDaol.eo - .. - -- - F>ag.. 2 TOTRL P.l37 BP-00011658