Document RpyKeqQ6r61GYejxJ5J8E7r8E

M m6 - 417 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations AMU- Revised Page DuPont-5386 TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revision No. 1 Volume 2 o f 5 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100(1998) Author: Gregory S. Ladies, Ph.D., D.A.B.T. Original Completed on: December 3, 2001 Revision No. 1 Completed on: April 5, 2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number Service Code Number1 Sponsor Study Number Company Sanitized. Does not contain TSCA CBI Page 317 of 1503 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS TREATMENT (mg/kg/day) o 1I 25 100 250 III V VII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. ! | HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. | j j | 1 1 1 (10) GO) (10) (11) 643272 643311 643259 643260 643309 643143 643173 643224 643174 643150 643179 643243 643193 643185 643180 643247 643194 643189 643228 643250 643201 643204 643240 643257 643215 643205 643264 643275 643252 643235 643290 643311 643259 643241 643292 643314 643260 643288 643308 643318 643298 643300 643315 643175 643174 643224 643193 643243 643194 643247 643201 643257 643215 643275 643252 643311 643259 643314 643260 643318 643298 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates .the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 318 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII LIVER HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, CENTRILOBULAR. (10) (10) (10) (11) 643309 643315 643189 643180 643250 643300 643264 643257 643189 643180 643224 643174 643290 643243 643259 643257 643309 643275 643311 643318 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBt 319 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) | TREATMENT 0 25 100 250 , | (mg/kg/day) 1 I III V VII PANCREAS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. ATROPHY. 1j (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643241 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643260 643298 643309 643315 643252 643259 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBt 320 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 250 1 I III V VII ESOPHAGUS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. EDEMA. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643174 643193 643194 643201 643215 643252 643260 643298 643315 643175 643259 64^309 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified jmpany Sanitized. Does not contain TSCA CBt 321 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) | TREATMENT 0 25 100 250 | (mg/kg/day) 1 I I III V VII STOMACH NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM 1 TREATMENT 1 (mg/kg/day) LESION INCIDENCE (NUMERIC) o 1 25 100 250 1 I 1 III V VII 1 DUODENUM NO ABNORMALITY DETECTED (10) 6431431 643150 I 6431851 6431891 6432041 643205 1 643235 1 6432411 643288 1 6433001 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT 0 (mg/kg/day) 1I 25 100 1 250 III V 1 1 VII JEJUNUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (1) 1 (11) 6431751643174 1643193 1643194 1643201 1643215 1643252 1643259 1643260 1643298 1643309 !643315 1 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) M ICROSCOPIC OBSERVATIONS IN MALE RATS LASTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | TREATMENT (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 I III V VII ILEUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS IGESTIVE SYSTEM | TREATMENT | (mg/kg/day) i LESION INCIDENCE (NUMERIC) 0 25 100 250 1 I III V VII CECUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA C B i 326 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT 0 (mg/kg/day) 1I 25 100 1 III V 250 VII COLON NO ABNORMALITY DETECTED (10) 1 643143 1 6431501 6431851 6431891 643204 1 643205 6432351 6432411 6432881 6433001 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified uinpany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 | I III V VII RECTUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (ID 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 'im pany Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT o 25 100 250 (mg /kg /day ) 1 1 I III V VII SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ompany Sanitized. Does not contain TSCA CBI 329 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. HYPERTROPHY, TUBULAR. 1 TREATMENT 1 (mg/kg/day) 1 o I 25 100 250 III v VII (10) (10) GO) (11) 643143 643173 643224 643185 643179 643243 643189 643240 643250 643205 643264 643257 643235 643272 643318 643288 643290 643308 643150 643180 643175 643193 643204 643228 643247 643194 643241 643292 643311 643215 643300 643314 643252 643298 643309 643275 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBf 330 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS URINARY SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII KIDNEYS HYPERTROPHY, TUBULAR. HYDRONEPHROSIS, UNILATERAL. HYDRONE PHRO SIS, BILATERAL. (10) (10) Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) (11) 643315 643259 6431741 1 Company Sanitized. Doss not contain TSCA CBI 331 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS URINARY SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT o (mg/kg/day) 1I 25 100 250 1 III V VII URINARY BLADDER NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT | (mg/kg/day) j o I 25 III RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. INFLAMMATION, GRANULOMATOUS. 1 1 1 1 (10) 1 643143 j 643150 j 643185| 643189| 6432351 643241| 643288| 643300| 643204| 643205| 1 i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 100 250 V VII (1) (11) 643174 643194 643201 643215 643252 643259 643298 643315 643260 643309 643175 643193 1 Company Sanitized. Does not contain TSCA I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I ) Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 250 | I III V VII TRACHEA NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB 334 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 I III V VII PHARYNX/LARYNX NO ABNORMALITY DETECTED HEMORRHAGE. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Doss not contain TSCA CBI 335 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) I LESION INCIDENCE (NUMERIC) LESIONS TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM. DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM. DEGENERATION, AMELOBLASTS. (10) (10) (10) (11) 643143 643173 643224 643150 643179 643243 643185 643180 643250 643189 643228 643314 643204 643240 643205 643264 643235 643272 643241 643290 643288 643292 643300 643308 643175 643201 643309 643309 643315 643175 643247 643174 643257 643193 643275 643194 643311 643201 643318 643215 643252 643259 643260 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Poss not contain TSCA CBi 336 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII NOSE DEGENERATION, AMELOBLASTS. (10) (10) (10) (11) 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TS C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) M ICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 250 1 I III V VII I HEART NO ABNORMALITY DETECTED (10) 643143 643150 643185 643241 643288 CARDIOMYOPATHY. INFLAMMATION, SUBACUTE/CHRONIC. 643189 643204 643205 643235 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) (11) 643174 643193 643201 643215 643252 643260 643298 643309 643194 643259 643315 i 1 |643175 1 t-omoany Sanitized. Does confa>n TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM I LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 I 25 100 250 III V VII AORTA NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations 1 Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) 1 11 | LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM | TREATMENT (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 | I III V VII SPLEEN NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 340 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) 1 i LESIONS ! i __ . LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 1 I III V VII THYMUS NO ABNORMALITY DETECTED ATROPHY. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Joriipany Sanitized. Does not contain TS C A C W H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) 1 1 | LESIONS i 1 i_ LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 J MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED I 1 1 ! 1 1 1 1 I J . LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) 1I ___ 1 III V VII (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified impany Sanitized. Does not contain TSCA CBI 342 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) M ICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified smpany Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII 1 BONE MARROW NO ABNORMALITY DETECTED HYPERPLASIA, GRANULOCYTIC. (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11} 1 643174 1 643193 643194 1 643201 1 643215 1 643252 1 643259 j 643260 ! 643298 1 643315 1643175 643309 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 1 25 1 100 1 250 1 1 III 1 V 1 VII PITUITARY GLAND NO ABNORMALITY DETECTED 1 1 | GO) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) O D 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Company Sanitized. Does not contain TSCA CBI 345 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) | LESION INCIDENCE (NUMERIC) LESIONS ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. TREATMENT (mg/kg/day) 0 I 25 100 250 III v VII (10) (10) (10) (11) 643150 643179 643175 643235 643224 643174 643318 643193 643194 643201 643252 643259 643260 643298 643309 643315 643143 643173 643224 643174 643185 643180 643243 643193 643189 643228 643247 643194 643204 643240 643250 643201 643205 643264 643257 643215 643235 643272 643275 643252 643241 643290 643311 643259 643288 643292 643314 643260 643300 643308 643318 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI346 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM TFIE REPRODUCTION EVALUATION) 11 LESION INCIDENCE (NUMERIC) j LESIONS 1 1 1 |ENDOCRINE SYSTEM I 1 | PARATHYROID GLANDS | NO ABNORMALITY DETECTED 1 1 1 1 | 1 1 i i i TREATMENT (mg/kg/day) 0 1I 25 1 III 100 250 1 V VII (8) 643143 643150 643185 643204 643205 643235 643241 643300 (10) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) | TREATMENT | 0 | (mg/kg/day) | 1 11 | I 1 | (10) |643143 j643150 643185 j643189 j643204 j643205 |643235 j643241 |643288 |643300 25 III 100 250 V VII (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 348 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM | TREATMENT (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII BRAIN NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitised. Does not contain TSCA C H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS 1 |NERVOUS SYSTEM 1 1 | SPINAL CORD 1 NO ABNORMALITY DETECTED | 1 1 | 1 1 1 | | !! __ TREATMENT (mg/kg/day) 0 I 25 | III 100 V 250 VII (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 250 11 I III V VII SCIATIC NERVE NO ABNORMALITY DETECTED 1 1 1 1 i 1 (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified cmpany Sanitized. Does ot contain TSCA CB 351  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I I Revised Page ______________________________ _______ DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 1 I III V VII SKELETAL MUSCLE NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) O U 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified *>mpany Sanitized. Does not contain TSCA CBi 352 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) | LESIONS MUSCULAR AND SKELETAL SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 | 25 | 100 | 250 1 ! Ill | V | VII FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified "ompany Sanitized. Does not contain TSCA CBI 353 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS MUSCULAR AND SKELETAL SYSTEM TREATMENT (mg/kg/day) o 1I 25 1 III 100 1 250 1 V 1 VII STERNUM NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (1) 1 (11) 6431751643174 643193 1643194 j643201 1643215 1643252 1643259 1643260 1643298 I643309 1643315 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII MANDIBLE NO ABNORMALITY DETECTED 1 DEGENERATION, AMELOBLASTS. (10) (10) (9) (10) 643143 643173 643224 643150 643179 643243 643185 643180 643247 643189 643228 643250 643204 643240 643257 643205 643264 643311 643235 643272 643314 643241 643290 643318 643288 643292 643300 643308 643275 643174 643193 I 643194 643201 643215 643252 643259 643260 643298 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does no! contain TSCA CBI 355 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) I Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII TESTES NO ABNORMALITY DETECTED 1 1 ! 1 SPERMATID RETENTION, SEMINIFEROUS TUBULES. ! (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 643175 <mpany Sanitized. Does no! contain TSCA CB1 356 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM | LESION INCIDENCE (NUMERIC) | TREATMENT j (mg/kg/day) 1 o I 25 100 250 III V VII EPIDIDYMIDES NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 'mpany Sanitized. Done net contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) o 25 100 250 1 I III V VII | PROSTATE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. (10) 643143| 643150 | 643185| 643189 643204| 643205 643235 643241 643300 643288 (1) (11) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643175 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ^mpany Sanitized. Does no! contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM LESION INCIDENCE (NUMERIC) TREATMENT o 25 100 250 (mg/kg/day) 1 ' 1 I III V VII SEMINAL VESICLES NO ABNORMALITY DETECTED (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 (1) (11) 643175 643174 643193 643194 643201 643215 643252 643259 643260 643298 643309 643315 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB! 359 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CUTANEOUS SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 | 250 1j I III V | VII | SKIN NO ABNORMALITY DETECTED 1 1 (10) 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (U ! d u 643175 j643174 |643193 |643194 j643201 j643215 j643252 643259 |643260 I643298 1643309 643315 i Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) j LESIONS | SPECIAL SENSES SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 j 25 | 100 | 250 1 | III j V 1 VII EYE(S) WITH OPTIC NERVE NO ABNORMALITY DETECTED i 1 1 1 1 [ OPTIC NERVE NOT PRESENT. 1 ] FOLD/ROSETTE, RETINAL. (10) 643143 643150 643185 643189 643204 643235 643241 643288 643300 643205 (1) (11) 643175 643174 643194 643201 643215 643252 643259 643260 643298 643315 643252 643309 643193 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ipany Sanitized. Does not contain TSCA CBI 361 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Males LESIONS DIGESTIVE SYSTEM LIVER NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. | TREATMENT 1 (mg/kg/day) 1 0 I 250 VII (10) (10) 643316 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643296 643303 643316 643304 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBl 362 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NCN-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM LIVER FOCUS OF CELLULAR ALTERATION, BASOPHILIC. FATTY CHANGE, MEDIAN CLEFT. FATTY CHANGE, CENTRILOBULAR. LESION INCIDENCE (NUMERIC) Males | TREATMENT (mg/kg/day) I 0 1 250 VII (10) (10) 643151 643253 643316 643246 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ^22S no contain TSCA CBI 363 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. HYPERTROPHY, TUBULAR. HYDRONEPHROSIS, UNILATERAL. LESION INCIDENCE (NUMERIC) 1------------- 1 Males TREATMENT | 0 (mg/kg/day) | 11 | 250 | 1 VI1 (10) (10) 643162 643165 643172 643220 643262 643225 643303 643258 643304 643296 643195 643234 643226 643236 643237 643266 643246 643316 643253 643151 643266 643234 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does no! contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED ODONTODYS PLASIA. DEGENERATION, AMELOBLASTS. LESION INCIDENCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 I | 250 | I VII (10) (10) 643172 643266 643195 643226 643237 643246 643253 643262 643303 643304 643162 643151 643165 643220 643225 643234 643236 643258 643296 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) 1 1 1 1 | LESIONS 1 LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED THYMUS NO ABNORMALITY DETECTED MANDIBULAR LYMPH NODE ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS. LESION INCIDI:NCE (NUMERIC) Males TREATMENT (mg/kg/day) 0 1 250 VII (1) 643304 (1) (1) 643304 643236 (1) 643304 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBf 366 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. LESION INCIDENCE (NUMERIC) Males | TREATMENT | (mg/kg/day) 1 0 I 250 VII (10) (10) 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643266 643303 643296 643304 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCACBI 367 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM MANDIBLE NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) 1 Males TREATMENT 0 (mg/kg/day) | 11 | 250 | 1 VI1 (10) (10) 643162 643151 643172 643165 643195 643220 643226 643225 643237 643234 643246 643236 643253 643258 643262 643266 643303 643296 643304 643316 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified C o m p a n y Sanitized. Does not contain TSCA CBf 368 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Males LESIONS TREATMENT (mg/kg/day) 0 1I 250 VII REPRODUCTIVE SYSTEM TESTES DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL. DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL. 1 1 1 (2 ) 1643226 1643253 (1) 643220 EPIDIDYMIDES NO ABNORMALITY DETECTED OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL. 1 (2) (1) 1643226 1643253 643220 SEMINAL VESICLES NO ABNORMALITY DETECTED (1) 643220 ! Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 369 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) 1 1 | LESIONS | !1___________________ DIGESTIVE SYSTEM ...... .. |LIVER | NECROSIS, FOCAL. | | INFLAMMATION, SUBACUTE/CHRONIC. 1 | 1 1 | HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. | FATTY CHANGE, MEDIAN CLEFT. j FATTY CHANGE, CENTRILOBULAR. -------------| TREATMENT (mg/kg/day) _ j _____________ LESION INCIDENCE (NUMERIC) 0 | 25 | 100 | 250 1 | III | V | VII (5) 643210 643145 643210 643232 643265 643268 643232 (5) (5) 643169 643283 643206 643159 643149 643169 643152 643181 643178 643206 643283 643286 643295 643152 643149 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized, D oes no! contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED CALCULUS\CALCULI. NEPHROPATHY, CHRONIC PROGRESSIVE. INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA, TRANSITIONAL CELL. LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) o 1I 25 ! III 100 1 v 250 VII (5) 643232 643265 643145 643210 643268 (5) 643149 643152 643178 643283 643295 643149 643149 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) . LESIONS | TREATMENT j (mg/kg/day) I1 |RESPIRATORY SYSTEM Ii NOSE ^ | NO ABNORMALITY DETECTED 1 1 | INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT. INFLAMMATION, SUBACUTE/CHRONIC. i 1 1 | HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM. | HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM. I i1 j FRACTURE/CALLUS, TOOTH. | DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM. | DEGENERATION, AMELOBLASTS. 1 | SCHWANNOMA [B]. LESION INCIDENCE (NUMERIC) 0 25 100 250 I III V VII (5) (5) (5) (5) 643210 643306 643169 643232 643206 643265 643286 643305 643181 643145 643202 643159 643149 643268 643293 643181 643178 643310 643283 643295 643145 643202 643159 643149 643268 643181 643202 643178 643293 643283 643310 643159 643295 643159 643152 643295 643202 [B] Benign tumour Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 372 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 44 (CONTINUED) MICROSCOPIC OBSERVATIONS IN MALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM | LESION INCIDENCE (NUMERIC) | TREATMENT | (mg/kg/day) j o I 25 100 250 III V VII THYROID GLAND ALTERATION, COLLOID. 1 1 1 ! 1 (5) (5) (5) (5) 643145 643202 643159 643149 643210 643293 643169 643152 643232 643305 643181 643178 643265 643306 643206 643283 643268 643310 643286 643295 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) 1 1 LESIONS ! _____ TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR. FATTY CHANGE, MEDIAN CLEFT. (10) (10) (10) (11) 643354 643321 643322 643340 643368 643362 643489 643361 643324 643323 643359 643362 643364 643366 643370 643374 643380 643367 643404 643398 643389 643392 643408 643406 643390 643409 643435 643436 643396 643461 643446 643463 643410 643462 643466 643477 643433 643472 643486 643458 643489 643332 643341 643359 643370 643404 643408 643435 643446 643466 643374 643458 N-l1 in Group VIII reflects one reproduction designated animal that died on test day 53. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBl 374 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII LIVER FATTY CHANGE, MEDIAN CLEFT. (10) (10) 643398 (10) (11) PANCREAS NO ABNORMALITY DETECTED ATROPHY. (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 i643466 i 643435 1643446 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 375 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/'CHRONIC. | TREATMENT | (mg/kg/day) HO H LESION INCIDENCE (NUMERIC) 25 100 250 IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 643368 Figure in parentheses is number of aniinals niicroscopicfilly examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) | TREATMENT 0 1 25 1 100 1 250 | (mg/kg/day) 1 II 1 IV 1 VI 1 VIII 1 1 (10) 1 (1) 6433541643321 6433611 643362 1 6433741 6433981 6434061 643436 643463 6434771 6434861 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 377 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) o 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS DIGESTIVE SYSTEM | TREATMENT o 25 100 250 | (mg/kg/day) 1 1 II IV VI VIII JEJUNUM NO ABNORMALITY DETECTED 1 i j s AUTOLYSIS: 1 NECROPSY AND HISTOLOGY PERFORMED. (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 1643466 1643340 1643368 i C o m p a n y S a n itize d . D o e s not contain TSCA CBI 379 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB" 380 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I ) Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 | 25 | 100 | 250 111 II 1 IV I VI I VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Fiyure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB 381 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NXMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA, 382 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED I TREATMENT I (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 I 25 I II I IV I 100 I I VI 250 VIII ( 10) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 (1 ) 643321 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified mpany Sanitized. Does not contain TS C A CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 1 25 1 100 I 250 111 II 1 IV 1 VI 1 VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS URINARY SYSTEM 1 TREATMENT 0 25 100 250 1 (mg/kg/day) 1 II IV VI VIII KIDNEYS NO ABNORMALITY DETECTED 1 1 1 1 ! 1 NEPHROPATHY, CHRONIC PROGRESSIVE. 1! 1 !1 1 NECROSIS, TUBULAR. INFLAMMATION, ACUTE. i1 1 T ATI? J.XM XD P m1 . [ HYPERPLASIA, TRANSITIONAL CELL. HYDRONEPHROSIS, BILATERAL. CYST. 1 AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. 1 (10) (10) GO) (11) 643354 643324 643322 643332 643361 643380 643366 643340 643374 643389 643367 643341 643406 643390 643409 643359 643463 643410 643461 643368 643486 643433 643462 643435 643458 643472 643446 643362 643364 643323 643370 643398 643396 643392 643404 643477 643489 643408 643466 643321 643321 643370 643321 643321 643436 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 385 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS TREATMENT 0 1 25 1 100 1 250 (mg/kg/day) 111 ii i v ! vi 1 v i n URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED HYPERPLASIA, SIMPLE, TRANSITIONAL CELL. ! 1 (10) 1 (1) 6433541 6433611 6433621 6433741 643398 j 643406 j 643436| 6434631 643477 j 643486 j j643321 1 (10) 643332 643340 643341 643359 643368 643370 643404 643408 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS RESPIRATORY SYSTEM TREATMENT 0 25 100 250 (mg/kg/day) 1 II IV VI VIII LUNGS NO ABNORMALITY DETECTED THROMBUS. 1i (10) (1) (1) (11) 643354 643321 643392 643332 643361 643340 643362 643341 643374 643359 643398 643368 643406 643370 643436 643404 643477 643408 643486 643435 643446 643466 643463 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does nof contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ______________________ RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED | TREATMENT (mg/kg/day) ' LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals mii-rotscopical ly tJXdirixned. for this tissue The absence of a number indicates the lesion specified was not identified C o m p a n y S an itize d . D o e s not contain TSCA CBf 388 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED | TREATMENT j (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 | 1 (ID 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBf H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS TREATMENT 0 1 25 1 100 1 250 (mg/kg/day) !11 II 1 IV 1 VI 1 VIII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. FRACTURE/CALLUS, TOOTH. DEGENERATION, AMELOBLASTS. !i (10) (10) (10) (11) 643354 643321 643323 643361 643324 643392 643362 643364 643462 643374 643380 643489 643398 643390 643406 643396 643436 643410 643463 643433 643477 643458 643486 643389 643340 643389 643322 643332 643366 643340 643367 643341 643409 643359 643461 643368 643472 643370 643404 643408 643435 643446 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI' H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS RESPIRATORY SYSTEM | LESION INCIDENCE (NUMERIC) I TREATMENT |0 I (mg/kg/day) | I jII |25 |100 j| IIV jVI 250 VIII NOSE DEGENERATION, AMELOBLASTS. (10) (10) (10) I (11) I643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Doss no, contain TSCA CB, 391 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED CARDIOMYOPATHY. LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 1 11 25 100 1 IV VI 250 VIII (10) 643354 643361 643374 643406 643463 643477 643486 (1) 643362 643321 643398 643436 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED DEPLETION, LYMPHOID. TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) o 25 100 250 1 II IV VI VIII (10) (1) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 643321 (10) 643332 643359 643370 643404 643408 643435 643446 643466 643340 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) LESIONS | TREATMENT 0 25 100 1 250 | (mg/kg/day) 1 1 II IV VI 1 VIII LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 THYMUS NO ABNORMALITY DETECTED ATROPHY. (10) 643354 (1) 643361 643362 643374 643398 643406 643436 643463 643477 643486 643321 1 (11) 1643332 1643341 1643359 1643370 1643404 1643408 1643435 1643446 1643466 1 1643340 1643368 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 396 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) TREATMENT (mg/kg/day) 0 1 II 25 100 1 IV VI 250 VIII (9) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 (9) 643332 643340 643341 643359 643368 643404 643408 643435 643446 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED HYPERPLASIA, GRANULOCYTIC. ATROPHY. LESION INCIDENCE (NUMERIC) TREATMENT o 25 100 250 (mg/kg/day) 1 1 II IV VI VIII (10) 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 (1) 643321 (ID 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 643368 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 398 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESION INCIDENCE (NUMERIC) | LESIONS | ENDOCRINE SYSTEM | TREATMENT 0 25 100 250 (mg/kg/day) 1 II IV VI VIII THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR. ALTERATION, COLLOID. GO) (10) (10) (11) 643354 643321 643322 643340 643361 643364 643323 643368 643362 643390 643367 643370 643374 643396 643392 643398 643409 643406 643472 643436 643463 643477 643486 643359 643404 643408 643435 643446 643466 643324 643366 643332 643380 643461 643341 643389 643462 643359 643410 643489 643408 643433 643435 643458 643446 Figure ir. parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 400 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. PARATHYROID GLANDS NO ABNORMALITY DETECTED | TREATMENT (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 250 II IV VI VIII (10) (10) (10) (11) 643466 (6) (1) 643354 643321 643362 643374 643406 643436 643463 (7) 643332 643341 643368 643404 643408 643435 643466 igure in parentheses is number of animals microscopically examined for this tissue he absence of a number indicates the lesion specified was not identified mpany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NGN-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 1 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TS C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) TREATMENT 0 25 100 250 (mg/kg/day) 1 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Poes not co nta in T S C A c m 403 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 1 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Cmpany Sanitized. Does no! contain TSCA BI 404 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED | LESION INCIDENCE (NUMERIC) TREATMENT | 0 25 100 250 (mg/kg/day) | 1 1 11 IV VI VIII 11 1 1 (10) (1) 1643354 643321 1643361 1643362 1643374 1643398 1643406 1643436 1643463 643477 1643486 (ID 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number ot animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) | LESION INCIDENCE (NUMERIC) | LESIONS 1 1 11 |MUSCULAR AND SKELETAL SYSTEM |1 |SKELETAL MUSCLE j NO ABNORMALITY DETECTED 1 1 1 1 1 1 | 1 | 1 1 TREATMENT | 0 25 100 250 (mg/kg/day) | 1 11 IV VI VIII 1 (10) (1) 1643354 643321 1643361 j643362 1643374 1643398 j643406 j643436 j643463 1643477 1643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 .figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified C o m p an y Sanitized. Does not contain TSCA CBI 406 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 | II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified apany Sanitized. D o es n t contain TSCACBI 407 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION)) LESIONS MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 | 25 | 100 | 250 111 II I IV I VI I VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified mpany Sanitized. Does not contain TSCA CBI 408 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS MUSCULAR AND SKELETAL SYSTEM | TREATMENT 1 (mg/kg/day) 1 LESION INCIDENCE (NUMERIC)| 1 0 25 100 250 1 1 IV VI VIII MANDIBLE NO ABNORMALITY DETECTED DEGENERATION, AMELOBLASTS. 1 ! (10) (9) (10) (8) 643354 643324 643322 643404 643361 643364 643323 643362 643380 643366 643374 643389 643367 643398 643390 643392 643406 643396 643409 643436 643410 643461 643463 643433 643462 643477 643458 643472 643486 643489 643332 643341 643359 643370 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 409 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) ) Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED j TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 !1 i ou 1643332 I643340 1643341 I643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 410 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NGN-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED DILATATION, LUMEN. | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643340 643359 643368 643370 643404 643408 643446 643466 643332 643341 643435 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 411 > H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I ) Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS REPRODUCTIVE SYSTEM MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 25 100 | 250 1 II IV VI I VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 j 1 (11) 1643332 j643340 |643341 |643359 |643368 |643370 |643404 |643408 j643435 |643446 |643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 412 ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 1 II IV VI VIII (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CB1 413 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS SPECIAL SENSES SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII EYE(S ) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT. AUTOLYSIS: NECROPSY AND HISTOLOGY PERFORMED. (10) (1) 643354 643321 643361 643362 643374 643398 643406 643436 643463 643477 643486 643463 a a *3 / n n UHjl / / TFhigeuraebseinncepaorefnathenusemsbeirs inndumicbaetresofthaenimleaslisonmiscproesccifoiepdicawlalys nexoatmiidneedntfiofiredthis tissue (11) 643332 643340 643341 643359 643368 643370 643404 643408 643435 643446 643466 643370 643446 643466 643340 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (90-DAY EXPOSURE EVALUATION INCLUDING EARLY DEATHS FROM THE REPRODUCTION EVALUATION) LESIONS DIGESTIVE SYSTEM | TREATMENT | (mg/kg/day) 1 LESION INCIDENCE (NUMERIC) o 50 250 1000 1 II IV VI VIII PANCREAS NO ABNORMALITY DETECTED (10) 641240 641245 641249 641283 641293 641384 ATROPHY. 641257 1 6412901 6413351 6413441 ! FThigeuraebseinncepaorefnathensuemsbeirs inndumicbaetresofthaenimleaslisonmiscproesccifoiepdicawlalys nexoatmiidneedntfiofiredthis tissue 1 1 (10) 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, MEDIAN CLEFT. LESION INCIDENCE (NUMERIC) Female | TREATMENT j (mg/kg/day) 1 0 II 250 VIII (10) (10) 643415 643351 643405 643444 643330 643345 643336 643347 643377 643358 643387 643423 643405 643441 643426 643444 643448 643456 643453 643474 643481 643425 643441 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Doe not contain TSCA C B f 416 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM LESION INCIDENCE (NUMERIC) Female | TREATMENT | (mg/kg/day) 1 o II 250 VIII PANCREAS NO ABNORMALITY DETECTED ESOPHAGUS NO ABNORMALITY DETECTED STOMACH NO ABNORMALITY DETECTED DUODENUM NO ABNORMALITY DETECTED JEJUNUM NO ABNORMALITY DETECTED (1) 643336 (1) 643336 (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals m i c r o s copically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 417 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED CECUM NO ABNORMALITY DETECTED COLON NO ABNORMALITY DETECTED RECTUM NO ABNORMALITY DETECTED SALIVARY GLANDS NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) |------------- | Female | TREATMENT | 0 | (mg/kg/day) | | 1 II | 250 | VIII (1) 643336 (1) 643336 (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 418 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Female LESIONS URINARY SYSTEM 1 TREATMENT 1 (mg/kg/day) 1 0 II 250 VIII KIDNEYS NO ABNORMALITY DETECTED NEPHROPATHY, CHRONIC PROGRESSIVE. 1 NECROSIS, TUBULAR. MINERALIZATION. 1 INFLAMMATION, ACUTE. 1 HYPERPLASIA, TRANSITIONAL CELL. 1 HYDRONEPHROSIS, BILATERAL. CYST. ! TFhigeuraebseinncepaorefnathensuemsbeirs inndumicbaetresofthaenimleaslisonmiscproesccifoiepdicawlalys nexoatmiidneedntfiofiredthis tissue (10) (10) 643387 643345 643405 643347 643448 643351 643474 643330 643358 643377 643423 643415 643441 643426 643444 643453 643456 643481 643336 643336 643336 643336 643425 643453 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS URINARY SYSTEM URINARY BLADDER INFLAMMATION, SUBACUTE/CHRONIC. 1 HYPERPLASIA, SIMPLE, TRANSITIONAL I HEMORRHAGE. CELL. LESION INCIDENCE (NUMERIC) Female I TREATMENT |0 I (mg/kg/day) | I III | 250 | || IVIII I | (1) | |643336j )643336| |643336| Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified CompanySanili* Doas no, M,,,ain ^ ^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED TRACHEA NO ABNORMALITY DETECTED PHARYNX/LARYNX NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) Female | TREATMENT j (mg/kg/day) ! 0 II 250 VIII (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Don, M,,ta|n TSCACBr 421 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Female LESIONS ITREATMENT I (mg/kg/day) I |0 | III | 250 | I VIII RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED SQUAMOUS HYPERPLASIA, NASOLACRIMAL DUCT. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT. DEGENERATION, AMELOBLASTS. ( 10) (10) 643330 643351 643336 643423 643377 643474 643387 643405 643425 643426 643448 643453 643415 643456 643345 643347 643358 643441 643444 643456 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified C o m p an y Sanitized. Does not contain TSCA CBr 422 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED AORTA NO ABNORMALITY DETECTED LESION INCIDINCE (NUMERIC) Female TREATMENT (mg/kg/day) 250 VIII H1 O H! (l) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 423 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTED- NEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED THYMUS ATROPHY. MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED BONE MARROW HYPERPLASIA, GRANULOCYTIC. LESION INCIDENCE (NUMERIC) Female | TREATMENT | (mg/kg/day) 1 0 II 250 VIII (1) 643336 (1) 643336 (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does -HP?,Contain TSOA CBf 424 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDI]NCE (NUMERIC) Female LESIONS ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED | HYPERPLASIA, DIFFUSE. | TREATMENT | (mg/kg/day) 1 0 II 250 VIII (2) 643336 643415 THYROID GLAND | NO ABNORMALITY DETECTED | i ! ! ALTERATION, COLLOID. i i 1 1 1 ! (10) (10) 643336 643347 643387 643415 643448 643453 643330 643345 643377 643351 643405 643358 643425 643423 643426 643441 643444 643456 643474 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Female LESIONS ENDOCRINE SYSTEM | TREATMENT | (mg/kg/day) 1 0 II 250 VIII PARATHYROID GLANDS NO ABNORMALITY DETECTED (1) 643336 ADRENAL GLANDS | NO ABNORMALITY DETECTED 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) 643336 ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDENCE (NUMERIC) Female LESIONS NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED | TREATMENT 0 | 250 j (mg/kg/day) 1 1 II | VIII 1 (U 1 643336| SPINAL CORD NO ABNORMALITY DETECTED (U 1 643336| SCIATIC NERVE NO ABNORMALITY DETECTED Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) | 643336| 1 .npany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESION INCIDINCE (NUMERIC) Female LESIONS MUSCULAR AND SKELETAL SYSTEM TREATMENT (mg/kg/day) 1 0 II 250 VIII SKELETAL MUSCLE NO ABNORMALITY DETECTED (1) 643336 FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (1) 643336 STERNUM NO ABNORMALITY DETECTED (1) 643336 MANDIBLE NO ABNORMALITY DETECTED (10) (10) 643330 643345 643336 6433471 643377 643351 643387 643358 643405 643423 643415 643441 643425 643444 643426 643456 643448 643474 643453 643481 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ;mpany Sanitized. Does not contain TS C A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED UTERUS NO ABNORMALITY DETECTED MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED LESION INCIDENCE (NUMERIC) |------------- | Female | TREATMENT | 0 | (mg/kg/day) | | 1 II | 250 j | VIII (1) 643336 (1) 643336 (1) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified hipany Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS CUTANEOUS SYSTEM LESION INCIDENCE (NUMERIC) Female TREATMENT |0 (mg/kg/day) | I II | 250 | I VIII SKIN NO ABNORMALITY DETECTED (1 ) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBI 430 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NGN-NEOPLASTIC (ONE-MONTH RECOVERY EVALUATION) LESIONS SPECIAL SENSES SYSTEM LESION INCIDENCE (NUMERIC) Female 1 TREATMENT 1 o J (mg/kg/day) II 1 250 1 VIII EYE(S ) WITH OPTIC NERVE NO ABNORMALITY DETECTED (1 ) 643336 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CW 431 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA/SQUAMOUS METAPLASIA, TRANSITIONAL CELL. DEGENERATION, AMELOBLASTS. TREATMENT (mg/kg/day) LESION INCIDENCE (NUMERIC) 0 25 100 250 II IV VI VIII (5) 643384 643402 643383 643465 643484 643383 643465 643484 (5) (5) 643373 643487 643382 643412 643360 643356 643381 643450 643360 643356 643381 643388 643450 643329 643356 Fiyuie in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 TABLE 45 (CONTINUED) MICROSCOPIC OBSERVATIONS IN FEMALE RATS LISTING INDIVIDUAL ANIMALS AFFECTEDNEOPLASTIC AND NON-NEOPLASTIC (THREE-MONTH RECOVERY EVALUATION) LESIONS ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED ALTERATION, COLLOID. s LESION INCIDENCE (NUMERIC) | TREATMENT 0 25 100 250 | (mg/kg/day) 1 II IV VI VIII (5) (4) (5) (5) 643382 643383 643379 643360 643329 643384 643391 643373 643356 643402 643437 643381 643388 643465 643483 643412 643450 643484 643487 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSCA CBv 433 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 46 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF P, MALE RATS GROUP DOSE (mg/kg/day) N TEST DAY 78 85 92 99 106 1-0 III-O V-0 VII-0 0 25 100 250 20 20 20 19 MEAN BODY WEIGHT (grams) 555.6(62.6)<a 569.5(63.3) 583.4(64.4) 595.7(63.2) 607.6(64.7) 543.9(52.9) 555.3 (54.7) 568.8(56.5) 582.2(58.0) 590.5(62.5) 547.5(36.3) 559.3(39.0) 569.5(40.7) 579.1(45.6) 574.2(52.3) 495.0(48.1) 516.1(47.0) 531.1(51.7) 539.0(59.8) 547.2 (65.3) GROUP 1-0 III-O V-0 VII-0 DOSE (mg/kg/day) 0 25 100 250 N 20 20 20 19 TEST DAYS MEAN BODY WEIGHT GAIN (grams) 78-85 85-92 92-99 99-106 13.9(6.1)a 13.9(6.7) 12.3(5.5) 12.0(5.0) 11.4(8.5) 13.5(5.8) 13.4(6.4) 8.4(7.5) 11.7 (7.3) 10.2 (8.0) 9.7(10.3) -5.0(21.7)* 21.2(11.3) 14.9(8.4) 7.9(15.2) 8.3 (8.9)* 78-106 52.0(7.1) 46.7(16.5) 26.6(30.1) a Standard deviation is reported in parentheses 52.2(32.7) * Statistically significant difference from control by Jonckheere-Terpstra test (p < 0.05). Company Sanitized. Does not contain TSCA CBt 434 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 47 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N GESTATION DAY 0 7 14 21 II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 MEAN BODY WEIGHT (grams) 305.7(31.8)a 333.9(33.3) 367.0(35.1) 453.2 (39.0)c 315.2(23.3) 344.4(28.1) 370.0(22.4) 454.9(55.4)d 302.1(18.5) 333.4(17.1) 366.0(19.2) 432.7 (40.0)d 300.3(22.0) 329.2(28.6) 367.2(22.0)b 444.5(35.5)d GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 GESTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 28.2(6.0)a 33.1(5.4) 86.5(16.1)c 29.2(8.8) 25.5(14.2) 82.4(44.5)^ 31.3(6.9) 32.5(5.0) 71.9 (28.3) 28.9(23.0) 32.9(6.1)^ 82.0(33.5)b 0-21 146.1(19.3)c 135.8(45.7)d 135.1 (29.7) a Standard deviation is reported in parentheses, fa N = 13. c N = 10. d N = 11. 146.2(34.6)d There were no statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). Company Sanitized. Does not contain TSCA CBI 435 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 48 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N LACTATION DAY 0 7 14 21 II-O 0 13 IV-0 25 17 VI-0 100 14 MEAN BODY WEIGHT (grams) 345.5(36.2)3 346.9(31.0) 360.6(33.4) 351.2 (30.6) 351.6(29.8) 351.3(30.7) 380.9(18.9) 365.9(18.4) 337.2 (32.9) 350.0(21.0) 371.4(18.1) 360.4(14.8) VIII-0 250 13 341.7(21.2) 349.3(25.3) 362.7(28.9) 341.1(41.2) GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 17 VI-0 100 14 VIII-0 250 13 LACTATION DAYS MEAN BODY WEIGHT GAIN (grams) 0-7 7-14 14-21 1.4(22.1)^ 13.7 (20.7) -9.4(10.9) -0.3(22.6) 29.6(19.7) -15.0(14.2) 12.8(27.7) 21.4(11.2) -11.1(13.1) 7.6(17.0) 13.3(29.9) -21.5 (43.5) 0-21 5.7(20.8) 14.2(21.3) 23.1(28.5) a Standard deviation is reported in parentheses. -0.6(38.4) * Statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). Company Sanitized. Does not contain TSCA CBi 436 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 49 MEAN DAILY FOOD CONSUMPTION AND MEAN FOOD EFFICIENCY OF P, FEMALE RATS DURING GESTATION GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 V I -0 100 15 VIII-0 250 14 GESTATION DAYS MEAN DAILY FOOD CONSUMPTION (grams)1 0-7 7-14 14-21 24.8(3.9)3 29.5(3.7) 26.1(5.7) 25.2(2.9) 26.6(3.2) 27.2(3.4) 25.8(2.1) 28.4(1.9) 27.0(3.1) 26.8(4.5) 29.2(3.1) 26.5(4.5)^ 0-21 26.8(3.6) 26.4 (2.7) 27.1(1.8) a Standard deviation is reported in parentheses. b N = 13 . 27.6(2.5)^ There were no statistically significant differences from control by Jonckheere-Terpstra test (p < 0.05). GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 16 VI-0 100 15 VIII-0 250 14 GESTATION DAYS MEAN FOOD EFFICIENCY (grams weight gain/grams food consumed) 0-7 7-14 14-21 0.167(.046)a 0.162(.028) 0.553(.312) 0.163 (.039) 0.141 (.072) 0.365 (.238) 0.172( .031) 0.163 (.022) 0.395( .178) 0.134(.172) 0.165(.032) 0.440 (.206 )-k 0-21 0.268 (.053) 0.224 (.088) 0.241 (.057) a Standard deviation is reported in parentheses. b N = 13 . 0.254 (.056 )-b There were no statistically significant differences from control by One-Way Analysis of Variance (p < 0.05) . Company Sanitized. Does not contain TSC A CB1 437 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 50 SUMMARY OF CLINICAL OBSERVATIONS IN P, RATS Pi MALE RATS GROUP DOSE (mg/kg/day) N Number of Rats with Observation 1-0 III-O V-0 VII-0 0 25 100 250 20 20 20 19 OBSERVATIONS Alopecia Colored Discharge Eye{s) Colored Discharge Nose Teeth Clipped Teeth Crooked 1 0 21 0 0 02 0 0 01 0 0 0 5* 0 0 01 Total No. of Rats with Masses 000 Statistically significant trend by Cochran-Armitage test; p < 0.05. 0 Company Sanitized. Does not contain TSCA CBI 438 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 50 (CONTINUED) SUMMARY OF CLINICAL OBSERVATIONS IN P[ RATS Pi FEMALE RATS DURING GESTATION OBSERVATIONS Alopecia Diarrhea Sore Stained Abdomen Stained Face Stained Perineum Teeth Clipped Weak Wet Perineum Wet Underbody GROUP DOSE (mg/kg/day) N Number of Rats with Observation II-O IV-0 VI-0 VIII-0 0 25 100 250 18 19 19 17 1122 0001 1000 0 01 0 0001 0011 0001 0001 0001 0001 Total No. of Rats with Masses 0000 Note: This table includes clinical observations from pregnant animals only. Pi FEMALE RATS DURING LACTATION GROUP DOSE (mg/kg/day) N OBSERVATIONS Abnormal Gait or Mobility Alopecia Colored Discharge Nose Discharge Vaginal Opening Hunched Over Teeth Clipped O 1 H H Number of Rats with Observation IV- 0 VI-0 VIII-0 0 25 1 0 0 250 13 17 14 14 0010 134 1 0010 0 110 0010 000- Total No. of Rats with Masses 0000 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. Company Sanitized. Does not contain TSCA CBI 439 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 51 MEAN ESTROUS CYCLE PARAMETERS AND PRECOITAL INTERVAL IN P, FEMALE RATS Percent Percent Percent o f Days of Days of Days Mean Cycle Dose in in in Length Group (mg/kg/day) N Estrus Diestrus Proestrus (days) Mean Precoital Interval (days) II-O 0 20 29 60 11 4.7(1.54)a '* 3.8(2.46)c IV-0 25 19 22 65 13 4.5(0.81) 3.3(2.86) VI-0 100 20 25 63 12 4.6(0.73)* 2.5(1.31)* VIII-0 250 18 20 69 12 a Standard deviation is presented in parentheses. b N=19 c N=18 d N=17 4.7(1.35) 3.6(2.21)* There were no significant trends (Jonckheere's test); p < 0.05. Company Sanitized. Does not contain TSCA CB! 440 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 52 SUMMARY OF SPERM PARAMETERS IN Pi MALE RATS Group Dose (mg/kg/day) 1-0 0 III-O 25 V-0 100 MOTILITY Percent Motile S.D. 93.3 3.6(10)a 92.2 5.8(10) 93.3 4.0(10) MORPHOLOGY Percent Normal S.D. 98.8 0.8(10) 99.0 1.1(10) 99.2 0.7(10) EPIDIDYMAL SPERM (Millions ) Per Cauda 298.7 S.D. 32.3(10) 279.8 39.8(10) 278.0 44.9(10) Per gram Cauda S.D. 1030.9 171.6(10) 998.3 144.3(10) 949.8 178.4 (10) TESTICULAR SPERMATIDS (Millions) Per Testis 130.1 S.D. 17.1(10) 121.8 13.6(10) 159.9* 10.3(10) Per gram Testis S.D. 84.5 12.3(10) 84.5 12.0(10) 101.1* 9.1(10) VII-0 250 90.3 6.1(10) 98.9 1.1(10) 299.2 66.9(10) 945.7 150.5(10) 146.5* 17.3(10) 93.2* 9.5(10) a Number in group is in parentheses. Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. Company Sanitized. Does not contain TSCA CBt 441 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 53 SUMMARY OF REPRODUCTIVE INDICES: P, GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 25 VI-0 100 VIII-0 250 MATING INDEX (%) (# copulated/cohoused) 90.0 100.0 95.0 94.7 (18/20) (20/20) (19/20) (18/19) FERTILITY INDEX (%) (# delivered/copulated) 72.2 85.0 73.7 77.8 (13/18) (17/20) (14/19) (14/18) GESTATION LENGTH (days) 22.3 22.2 22.4 22.4 Number of Implantation Sites per pregnant female 14.0 13.4 (4.53)3 (4.58) 13.9 (2.95) 14.1 (2.93) Implantation Efficiency (%)* 96.6 (3.33) 90.5 83.4* 84.5* (13.47) (16.16) (19.10) a Standard deviation is reported in parentheses. b Number of pups born/number of implantation sites X 100. There were no statistically significant trends in mating or fertility indices by Cochran-Armitage test; p < 0.05. There was no statistically significant difference from control in gestation length by One-Way Analysis of Variance; p < 0.05. * Statistically significant trend by Jonckheere's test; p < 0.05. Company Sanitized. Does not contain TSCA CBI 442 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 54 MEAN PUP NUMBERS AND SURVIVAL: Fj GENERATION O 1 H> MATERNAL GROU P DOSE (mg/kg/day) N 11-0 0 13 IV-0 25 17 viii-o 100 250 14 13 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF PUPS/LITTER 14.7 14.6 14.6 8.0 8.0 8.0 8.0 13.4 13.2 12.9 7.6 7.6 7.6 7.6 12.4 11.3 10.0* 6.3 6.3 6.3 6.3 12.5* 12.1* 11.8* 7.5 7.4 7.4 7.4 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF MALE PUPS/LITTER 8.7 7.2 5.9 7.1 8.6 7.1 5.4 6.7 8.6 7.1 4.7 6.5 4.2 3.6 3.3 3.6 4.2 3.6 3.3 3.9 4.2 3 .6 3 .3 3.6 4.2 3 .6 3.3 3.6 Born Born Alive Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN NUMBER OF FEMALE PUPS/LITTER 6.0 6.1 6.5 5.5 6.0 6.1 5.9 5.4 6.0 5.8 5.3 5.3 3.8 4.0 3 .0 3.8 3.8 4.0 3 .0 3.8 3.8 4.0 3.0 3.8 3.8 4.0 3.0 3.8 Sex Ratio (males) Gestation Index3 Mean % Born Alive 0-4 Day Viability Lactation I n d e x - 6 Litter Survival0 SURVIVAL (% ) 0.59 100.0 99.5 100.0 100.0 100.0 0.50 100.0 99.2 97.6 100.0 100.0 a Percent litters delivered having at least one live pup. b Mean percent survival from day 4 postculling to day 21. c Percent litters born with at least one pup alive on day 21. 0.50 92 .9 88.4 90.6 100.0 92.3 0.56 100.0 92.4 97.3 92.3 92.3 * Statistically significant trend by Jonckheere-Terpstra test; p < 0.05. Statistics were performed on combined pups per litter only. Male and female data are presented for information only. Company Sanitized. Does not contain TSCA CBt 443 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 55 MEAN PUP WEIGHTS: Fj GENERATION MATERNAL GROUP DOSE (mg/kg/day) N II-O 0 13 IV-0 25 17 VI-0 100 13 VIII-0 250 13 Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 MEAN PUP WEIGHTS (grams) 6.9 (0.7)a 11.3 (1.5) 11.4 (1.6) 18.3 (1.9) 37.9 (3.4) 60.9 (6.9) 6.7 (0.6) 11.4 (1.6) 11.4 (1.7) 18.0 (2.2) 37.0 (3.0) 60.3 (5.5) 6.8 (0.7 )-k 11.9 (1.8) 11.9 (1.9) 18.3 (2.4) 36.1 (3.2) 58.3 (4.3) 6.4 (0.6) 10.1 (1.7)* 10.1 (1.7)* 15.5 (2.1)* 29.5 (3.4)* 45.4 (7.7)* MEAN MALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 7.0 (0.7) 11.6 (1.5) 11.7 (1.5) 18.8 (2.0) 38.7 (3.6) 62.5 (7.4) 6.9 (0.7) c 11.5 (1.7) 11.5 (1.7) 18.2 (2.3) 37.7 (3.2) 61.7 (6.2) 6.9 (0.8)b 12.3 (1.9) 12.3 (2.0) 18.9 (2.3) 37.1 (3.1) 60.2 (4.3) 6.7 (0.5) 10.7 (0.8) 10.8 (0.7) 15.7 (2.3) 29.6 (3.8) 45.7 (7.7) MEAN FEMALE PUP WEIGHTS (grams) Day 0 Day 4 Preculling Day 4 Postculling Day 7 Day 14 Day 21 6.6 (0.7) 10.9 (1.5) 11.0 (1.6) 17.6 (1.9) 37.0 (3.2) 59.1 (6.3) 6.5 (0.6) 11.1 (1.8) 11.2 (1.8) 17.6 (2.2) 36.5 (3.0) 59.0 (5.5) a Standard deviation is reported in parentheses. b N = 12. c N = 14. 6.5 (0.7 )-b 11.5 (1.7) 11.4 (1.9) 17.5 (2.7) 35.0 (3.6) 56.0 (4.7) 6.2 (0.6) 9.8 (1.7) 9.9 (1.8) 15.3 (2.0) 29.3 (3.1) 45.0 (8.0) * Statistically significant trends by linear contrast of least square means; p < 0.05. Note; Statistical analyses were conducted on the combined pup weights. Male and female data are presented for information only. mpany Sanitized. Does not contain TSCA CBI 444 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 56 SUMMARY OF PUP CLINICAL OBSERVATIONS: F, GENERATION MATERNAL GROUP II-O DOSE (mg/kg/day) 0 IV-0 25 VI-0 100 VIII-0 250 OBSERVATIONS Discharge Nose Weak 0 0 0 3 ( l)a 0 0 0 2 ( 1) TOTAL NUMBER OF OBSERVATIONS NUMBER OF LITTERS AFFECTED TOTAL NUMBER OF LITTERS 0 00 5 0001 13 17 13 13 a Numbers outside the parentheses are the number of pups affected; the numbers in parentheses are the number of litters affected. There were no statistically significant trends by Cochran-Armitage test; p < 0.05. Company Sanitized. Does rot contain TSCA CB1 445 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 57 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF Fi MALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TESTS 1 8 15 22 29 36 1-1 0 13 63.3(7.5)* 108.7 (12.8) 172.2 (18.0) 236.3(21.9) 294.7 (31.0) 333.4(33.5) III-l 25 16 V-l 100 12 MEAN BODY WEIGHT (grams) 62.5(7.0) 103.9(10.3) 163.9(15.3) 224.0(16.9) 278.7(23.6) 331.8 (31.3)c 58.6(5.6) 100.5(8.9) 161.3(13.0) 223.0(11.5) 279.2(20.4) 310.5(35.5) VII-1 250 12 47.0(5.3)* 88.0(6.8)* 144.5(11.6)* 206.0(11.4)* 264.0(28.4)* 310.2(40.2)* GROUP DOSE (mg/kg/day) N 1-1 0 13 III-l 25 16 V-l 100 12 DAYS ON TEST3 MEAN BODY WEIGHT GAIN (grams) 1-8 8-15 15-22 22-29 29-36 45.3(6.4)* 63.5(6.8) 64.1(7.0) 58.4(13.8) 38.7(31.8) 41.5(5.0) 60.0(6.0) 60.1(5.5) 54.7(16.5) 54.6 (20.1)c 41.9(4.4) 60.8(5.2) 61.7(5.0) 56.3(15.6) 31.2(19.3) 1-36 270.1(30.2) 269.7 (28.9)c 251.9 (33.3) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses, c N = 15. VII-1 250 12 41.0(7.4) 56.5(6.7)* 61.5(5.7) 58.0 (22.5) 46.1(25.5) 263.2(42.3) * Statistically significant trend by Jonckheere-Terpstra test p < 0.05. Company Sanitized. Does not contain TSCA C 446 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 58 MEAN BODY WEIGHTS AND MEAN BODY WEIGHT GAINS OF F, FEMALE RATS GROUP DOSE (mg/kg/day) N DAYS ON TESTa 1 8 15 22 29 36 II-l 0 13 57.3 (6.3 ) b 94.0(7.8) 135.8(9.6) 167.5(13.4) 190.0(17.5) 206.4(16.3) IV-1 25 17 V I -1 100 12 VIII-1 250 12 MEAN BODY WEIGHT (grams) 58.6(6.3) 94.8(8.3) 139.6(13.9) 173.7(21.6) 195.6(24.2) 218.8(30.7)c 56.7(4.9) 90.4(7.0) 133.6(8.3) 167.5(10.8) 191.4(15.8) 212.6((17.7) 44.7(8.1)* 80.0(9.6)* 124.8 (9.1)* 161.7(9.8) 187.7 (13.4) 206.3(13.9) GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 VI-1 100 12 DAYS ON TESTS MEAN BODY WEIGHT GAIN (grams ) 1-8 8-15 15-22 22-29 29-36 36.8(4.2)^ 41.8(6.4) 31.7(8.4) 22.5(6.1) 16.4(7.0) 36.2(3.8) 44.7(7.1) 34.2(9.1) 21.9(7.7) 22.6 (9.1)c 33.7(5.4) 43.2(5.7) 33.9(5.4) 23.9(6.9) 21.1(4.2) 1-36 149.1(17.7) 160.3 (26.7)c 155.9 (16.3) a Day of Weaning = Test Day 1. b Standard deviation is reported in parentheses. c N = 16 . VIII-1 250 12 35.2 (6.4) 44.8(4.1) 36.9(5.6) 26.0(8.3) 18.6(13.1) 161.5(18.7) Statistically significant trend by Jonckheere-Terpstra test ; p < 0.05. Company Sanitized. Does not contain TSCA CBI 447 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 59 SUMMARY OF CLINICAL OBSERVATIONS IN Fi RATS Fj. MALE RATS Number of Rats with Given Observation GROUP 1-1 III-l V-l VII-1 DOSE (mg/kg/day) 0 25 100 250 N 13 16 12 12 OBSERVATIONS There were no abnormal clinical observations observed in the Fx Male Rats. Total No. of Rats with Masses Fj FEMALE RATS Number of Rats with Given Observation GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 VI-1 100 12 VIII250 12 OBSERVATIONS Alopecia 0100 Total No. of Rats with Masses 0000 There were no statistically significant trends by Cochran-Armitage test; p < 0.05. Company Sanitized. Does not contain TSCA CBI 448 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 60 SUMMARY OF DEVELOPMENTAL LANDMARKS IN F, RATS PREPUTIAL SEPARATION - Fi MALE RATS GROUP 1-1 III-l V-l VII-1 DOSE (mg/kg/day) 0 25 100 250 N 13 16 12 12 (Days)a 39.9 (2.22) 41.5 (2.90) 43.2 (3.16) 42.7 (2.10) VAGINAL OPENING - Fx FEMALE RATS GROUP DOSE (mg/kg/day) N II-l 0 13 IV-1 25 17 V I -1 100 12 VIII-1 250 12 (Days)a 32.1 (2.43) 32.2 (2.28) Data summarized as: Mean Standard Deviation 32.1 (1.93) 32.5 (2.58) a Age was calculated as follows using data presented in Appendix L L : Test day + 20 days = Age (days). There were no statistically significant trends by linear contrast of least square means (covariate:body weight). tmpany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 61 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - P, ADULTS GROUP DOSE (MG/KG/DAY) THYROID FINAL BODY 1-0 0 0.021 0.003(12 ) 604.692 62.781(12 ) III-O 25 0.020 0.004(17 ) 594.429 57.077(17 ) V-0 100 0.022 0.005(14 ) 557.193 61.905(14 ) VII-0 250 0.025 0.007(14 541.471# 65.972(14 THYROID/FINAL BODY * 100 0.004 0.000(12 ) 0.003 0.001(17 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 0.004 0.001(14 ) 0.005# 0.001(14 Revised Page DuPont-5368 Company Sanitized. Does not contain TSCACBI 450 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 62 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Pi ADULTS GROUP DOSE (MG/KG/DAY) II-O 0 IV-0 25 THYROID 0.019 0.004(11 ) 0.021 0.004(17 ) FINAL BODY 351.700 365.888 33.050(11 ) 18.416(17 ) THYROID/FINAL BODY * 100 0.006 0 .001(11 ) 0.006 0.001(17 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra) No statistically significant difference at p < 0.05. VI-0 100 0.020 0.004(12 } 359.208 15.076(12 ) 0.006 0 .001(12 ) VIII-0 250 0.022 0.005(12 ) 338.008 41.391(12 ) 0.006 0 .002(12 ) Revised Page DuPont-5368 Company Sanitized, Does not contain TSCA CBI 451 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 63 MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) GROUP DOSE (MG/KG/DAY) 1-1 III-l V-l VII-1 0 25 100 250 BRAIN 1.996 0.093(13 ) 1.949 0.069(16 ) 1.966 0.106(12 ) 1.978 0.072(12 EPIDIDYMIDES 0.760 0.067(13 ) 0.738 0.092(16 ) 0.739 0.048(12 ) 0.686# 0.065(12 TESTES 3.300 0.228(13 ) 3.154 0.177(16 ) 3.220 0.254(12 ) 3.039# 0.439(12 SEMINAL VESICLES PROSTATE THYROID 1.200 0.205(13 ) 0.460 0.126(13 ) 0.019 0.004(13 ) 1.074 0.202(16 ) 0.409 0.083(16 ) 0.017 0.003(16 ) 1.085 0.257(12 ) 0.368 0.087(12 ) 0.015 0.004(12 ) 1.084 0.187(12 0.406 0.116(12 0.018 0.004(12 KIDNEYS 3.283 0.291(13 ) 3.154 0.264(16 ) 3.199 0.293(12 ) 3.253 0.270(12 LIVER 17.488 1.869(13 ) 16.938 1.829(16 ) 17.100 2.729(12 ) 16.037# 1.240(12 FINAL BODY 384.823 372.338 376.133 360.375# 31.437(13 ) 25.695(16 ) 26.968(12 ) 36.754(12 Revised Page DuPont-5368 Company Sanitfeed. Does noi contain TSCA CB1 452 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - F, ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DOSE (MG/KG/DAY) 1-1 III-l V-l VII-1 0 25 100 250 BRAIN/FINAL BODY * 100 0.521 0.034(13 ) EPIDIDYMIDES/FINAL BODY * 100 0.198 0.014(13 ) 0.525 0.028(16 ) 0.198 0.019(16 ) 0.525 0.049(12 ) 0.197 0.014(12 ) 0.553 0.048(12 0.191 0.015(12 TESTES/FINAL BODY * 100 0.860 0.044(13 ) SEMINAL VESICLES/FINAL BODY * 100 0.311 0.037(13 ) 0.848 0.034(16 ) 0.288 0.045(16 ) 0.860 0.091(12 ) 0.287 0.055(12 ) 0.843 0.077(12 0.303 0.057 (12 PROSTATE/FINAL BODY * 100 0.119 0.029(13 ) 0.110 0.020(16 ) 0.098 0.022(12 ) 0.112 0.024(12 THYROID/FINAL BODY * 100 0.005 0.001(13 ) KIDNEYS/FINAL BODY * 100 0.854 0.051(13 ) 0.005 0.001(16 ) 0.848 0.061(16 ) 0.004 0.001(12 ) 0.851 0.059(12 ) 0.005 0.001(12 0.906 0.068(12 Revised Page DuPont-5368 Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DOSE (MG/KG/DAY) 1-1 III-l 0 25 V-l 100 VII-1 250 LIVER/FINAL BODY * 100 4.543 0.290(13 ) 4.546 0.327(16 ) 4.525 0.479(12 ) 4.468 0.329(12 MEAN RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) GROUP DOSE (MG/KG/DAY) 1-1 III-l 0 25 LIVER/BRAIN*100 875.891 868.962 82.315(13 ) 90.420(16 ) KIDNEYS/BRAIN*10 0 164.486 12.752(13 ) 161.723 11.469(16 ) PROSTATE/BRAIN*10 0 23.017 5.990(13 ) 20.936 4.034(16 ) SEMINAL VESICLES/BRAIN*100 59.952 8.655(13 ) 55.060 10.071(16 ) TESTES/BRAIN*100 165.435 161.842 9.973(13 ) 8.064(16 ) V-l 100 873.051 149.566(12 ) 163.152 17.372(12 ) 18.712 4.085(12 ) 55.069 12.064(12 ) 164.109 14.137(12 ) VII-1 250 811.923 70.037(12 164.691 14.841(12 20.513 5.677 (12 54.769 9.181(12 153.809 22.378(12 Revised Page DuPont-5368 Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 63 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM MALE RATS - Fi ADULTS EPIDIDYMIDES/BRAIN*100 38.113 3.175(13 ) 37.831 4.196(16 ) 37.650 34.712# 2.899(12 ) 3.437(12 ) THYROID/BRAIN*100 _____________________ 0.953 0.861 0.215(13 ) 0.163(16 ) Data summarized as: Mean Standard Deviation (n) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 0.775 0.192(12 ) 0.933 0.221(12 ) Revised Page DuPont-5368 Company Sanitized. Does not contain TSCACBl 455 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 64 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - F[ ADULTS MEAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 VI-1 100 VIII-1 250 BRAIN 1.829 0.061(13 ) 1.849 0.082(17 ) 1.799 0.091(12 ) 1.810 0.057(12 UTERUS 0.429 0.087(13 ) 0.470 0.140(17 ) 0.450 0.115(12 ) 0.583 0.604(12 THYROID 0.016 0.003(13 ) 0.015 0.003(17 ) 0.016 0.003(12 ) 0.013 0.002(12 KIDNEYS 1.886 0.154(13 ) 2.038 0.249(17 ) 2.051 0.247(12 ) 2.039 0.211(12 LIVER 9.063 1.385(13 ) 9.589 1.727(17 ) 9.593 1.329(12 ) 9.986 0.958(12 FINAL BODY 218.431 226.071 223.750 222.475 19.969(13 ) 29.359(17 ) 19.600(12 ) 15.014(12 Revised Page DuPont-5368 Company Sanitized. Does no, contain TSCA CB, H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 64 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fi ADULTS MEAN RELATIVE ORGAN WEIGHTS (% of body weight) GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 BRAIN/FINAL BODY * 100 0.844 0.083(13 ) 0.829 0.096(17 ) UTERUS/FINAL BODY * 100 0.198 0.040(13 ) 0.210 0.065(17 ) THYROID/FINAL BODY * 100 0.007 0.001(13 ) 0.007 0.002(17 ) KIDNEYS/FINAL BODY * 100 0.867 0.079(13 ) 0.904 0.052(17 ) LIVER/FINAL BODY * 100 4.136 0.403(13 ) 4.227 0.406(17 ) VI-1 100 0.810 0.085(12 ) 0.203 0.057(12 ) 0.007 0.002(12 ) 0.921 0.119(12 ) 4.281 0.361(12 ) VIII-1 250 0.817 0.061(12 ) 0.258 0.251(12 ) 0.006 0.001(12 ) 0.917 0.079(12 ) 4.492# 0.372(12 ) MEAN RELATIVE ORGAN WEIGHTS (orqan to brain weight ratio) GROUP DOSE (MG/KG/DAY) II-l 0 IV-1 25 LIVER/BRAIN*100 496.052 517.938 77.065(13 ) 86.356(17 ) VI-1 100 534.812 80.407(12 ) VIII-1 250 552.297# 55.783(12 ) Revised Page DuPont-5368 Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TABLE 64 (Continued) MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Fj ADULTS MEAN RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) GROUP DOSE (MG/KG/DAY) H-l 0 IV-1 25 VI-1 100 VIII-1 250 KIDNEYS/BRAIN*10 0 103.192 8.825(13 ) 110.086 11.594(17 ) 114.319# 15.371(12 ) 112.713# 12.284(12 ) THYROID/BRAIN*100 0.867 0.164(13 ) 0.804 0.187(17 ) 0.898 0.189(12 ) 0.718 0.128(12 ) UTERUS/BRAIN*100 23.473 _________________________________ 4.657(13 ) Data summarized as: Mean Standard Deviation (n) 25.407 7.477(17 ) Statistical Methods: Trend test (Jonckheere-Terpstra). # Statistically significant difference at p < 0.05. 24.873 5.632(12 ) 32.194 33.171(12 ) Revised Page DuPont-5368 Com pany Sanitized. Desnoi contain TSCAcBf 458 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: TABLE 65 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - P, ADULTS H 1 O GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 0 20 III-O 25 20 V-0 100 20 EPIDIDYMIDES LARGE O'3 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 0 Revised Page DuPont-5368 VII-0 250 19 1 Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: TABLE 66 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Pi ADULTS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-O 0 20 IV-0 25 20 VI-0 100 20 LIVER DISCOLORATION 13 STOMACH DISTENDED WITH GAS 0 SMALL INTESTINE DISTENDED WITH GAS 0 KIDNEYS DILATATION 0 UTERUS HEMORRHAGE OBSTRUCTION 0 0 SKIN STAIN ALOPECIA 0 1 INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 Revised Page DuPont-5368 VI 25 19 0 1 1 1 1 1 2 0 Company Sanitized. Does nof contain TSCA CB1 460 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION: TABLE 67 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 1/1 IV-0 25 2/2 VI-0 100 7/3 VIII-0 250 5/3 STOMACH NO MILK SPOT PERITONEAL CAVITY CANNIBALIZED LUNGS NOT EXPANDED 0 ( 0) 0 ( 0) 0 ( 0) 2 ( 2) 0 ( 0) 2 { 2) 4 ( 1) 0 ( 0) 4 ( 1) 3 { 3) 1 ( 1) 3 ( 3) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0213 0244 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanifeed. Dona no. nomata TSCA CBI 461 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION: TABLE 68 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - F, PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 VI-0 100 8/3 VIII-0 250 4/2 STOMACH NO MILK SPOT LUNGS NOT EXPANDED 0 ( 0) 0 ( 0) 0 ( 0) 0 ( 0) 5 ( 1) 5 ( 1) 1( U 1 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0011 0051 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitteed. Does not contain TSCA CBI 462 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION: TABLE 69 INCIDENCES OF GROSS OBSERVATIONS IN RATS - Fi UNSEXABLE PUPS DAM GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER PUPS/LITTERS: II-O 0 0/0 IV-0 25 0/0 VI-0 100 0/0 VIII-0 250 13/1 WHOLE BODY AUTOLYSIS 0 ( 0) 0 ( 0} 0 ( 0) 10 ( 1) TOTAL LITTERS AFFECTED TOTAL PUPS AFFECTED 0001 0 0 0 10 For each group: The count of pups only includes those which underwent pathological examination. The count of litters only includes those in which pups underwent pathological examination. For each site/lesion: Numbers outside the parentheses are the number of pups affected. Numbers in parentheses are the number of litters affected. Company Sanitized. Does not contain TSCA CBF 463 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION: TABLE 70 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - F, WEANLINGS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 42 III-l 25 45 V-l 100 34 KIDNEYS LARGE SMALL________ 0a 1 0 0 10 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. VII-1 250 35 0 0 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION: TABLE 71 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - Fi WEANLINGS GROUP DESIGNATION: DOSE (MG/KG/DAY): NIMBER IN GROUP: II-l 0 36 IV-1 25 51 VI-1 100 30 VIII-1 250 37 THERE WERE NO GROSS OBSERVATIONS Company Sanitized. Does not contain TSCA CBI 465 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations SITE/LESION: TABLE 72 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Fi ADULTS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-1 0 13 III-l 25 16 V-l 100 12 KIDNEYS DILATATION ia a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. 3 6 Revised Page DuPont-5368 VII-1 250 12 0 Company Sanitized. Does not contain TSCA CBI 466 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 SITE/LESION : TABLE 73 INCIDENCES OF GROSS OBSERVATIONS IN FEMALE RATS - F, ADULTS GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: II-l 0 13 IV-1 25 17 V I -1 100 12 VIII-1 250 12 KIDNEYS DILATATION_____________________________________________ 0___________ 0___________ 2___________ 0 a INCIDENCES REFLECT THE NUMBER OF ANIMALS WITH A GIVEN LESION. Company Sanitized, does not contain Ts c a C B t H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 74 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN MALE REPRODUCTION RATS - P, ADULTS LESION GRADES TISSUE/LESION (P,1,2,3,4) GROUP DESIGNATION: DOSE (MG/KG/DAY): NUMBER IN GROUP: 1-0 0 20 III-O 25 20 v-o 100 20 VII250 19 TESTIS3 TESTES 4132 3233 EPIDIDYMIS3 EPIDIDYMIDES PROSTATE INFLAMMATION, SUBACUTE/CHRONIC SEMINAL VESICLES 4 3 7 1 (-,1,-,-, -) 7 1 2 3 3 3 3 6 1 (-,1, 6 2 3 5 1( 5 COAGULATING GLAND 7365 OTHER 0000 O THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. o LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". a One of the pair available for microscopic examination. Sperm parameter evaluation was performed on the second of the pair. Company Sanitized. Does not contain TSCA CEI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5368 TABLE 75 INCIDENCES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS IN FEMALE REPRODUCTION RATS - Pi ADULTS GROUP DESIGNATION: LESION GRADES DOSE (MG/KG/DAY): TISSUE/LESION (P,1,2,3,4) NUMBER IN GROUP: II-O 0 20 IV-0 25 20 v i -o 100 20 VIII-0 250 19 OVARIES 83 85 UTERUS DILATATION, GLAND/LUMEN VAGINA 83 85 - 1 (-,1, 3 (-,1,2,-,-) - 8385 OTHER LIVER: NECROSIS, FOCAL SKIN: NO ABNORMALITIES DETECTED 2 1 (-,1, 1 (1, 0 - - 00 ~- -- o THE NUMBER OF ORGANS EXAMINED FOR EACH GROUP IS UNDERLINED. o LESION GRADES: P = PRESENT; 1 = MINIMAL; 2 = MILD; 3 = MODERATE; 4 = SEVERE. o LESION GRADES CORRESPOND BY POSITION WITH THE NUMBERS IN PARENTHESES, WHICH INDICATE HOW OFTEN EACH GRADE WAS OBSERVED. FOR EXAMPLE: (-,1,2,-,-) MEANS NO LESIONS WERE GRADED "PRESENT" (NON-GRADED LESIONS), 1 LESION WAS GRADED "MINIMAL", 2 LESIONS WERE GRADED "MILD", NO LESIONS WERE GRADED "MODERATE" AND NO LESIONS WERE GRADED "SEVERE". Company S anitized. Does n o t co n ta in TSCA C 469 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURES Company Sanitized. Does not contain TSCkC&f 470 H -24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURES EXPLANATORY NOTES Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 90 Recovery period begins for rats designated for one-month and 3-month recovery periods. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 92 Last day o f test substance administration for female rats designated for the 90-day exposure period. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day o f non-fasted body weight data collection for rats designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day of non-fasted body weight data collection for rats designated for the 3-month recovery period. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. Company Sanitized. Does not contain TSCA CBI 471 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 1 MEAN BODY WEIGHTS OF MALE RATS Revised Page DuPont-5386 * On test day 74, male and female rats designated for reproduction evaluations were co-housed. On test day 77, all rats in the 250 mg/kg/day dose group were placed on ground chow. Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 2 MEAN BODY WEIGHTS OF FEMALE RATS Revised Page DuPont-5386 * On test day 74, male and female rats designated for reproduction evaluations were co-housed. On test day 77, all rats in the 250 mg/kg/day dose group were placed on ground chow. Company Sanitized. Does not contain TSCA CB1 473 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURE 3 MEAN FORELIMB GRIP STRENGTH FOR MALE RATS Forelimb Grip Strength (kg) 2.00 -i 1.80 1.60 1.40 1.20 1.00 0.80 0.60 -| 0.40 J |0.20 - 0.00 j Baseline Week 13 Assessment Period 0 mg/kg/day D 25 mg/kg/day I II100 mgkgday 250 mg/kg/day Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 4 MEAN FORELIMB GRIP STRENGTH FOR FEMALE RATS 1.60 Revised Page DuPont-5386 Forelimb Grip Strength (kg) 1.40 1.20 1.00 0 mg/kg/day 25 mg/kg/day 0.80 i 100 mgkgday IB 250 mg/kg/day 0.60 0.40 0.20 0.00 Baseline Week 13 Assessment Period Recovery Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations FIGURE 5 MEAN HINDLIMB GRIP STRENGTH FOR MALE RATS Revised Page DuPont-5386 Hindlimb Grip Strength (kg) 0 mg/kg/day 25 mg/kg/day I 100 mgkgday [ 250 mg/kg/day Week 13 Assessment Period 476 Recovery Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURE 6 MEAN HINDLIMB GRIP STRENGTH FOR FEMALE RATS 0.90 0.80 -J 0.70 - 0.60 H W) 0.50 j S-. 55 g 0.40 : =3 0.30 e 0.20 -! 0.10 0.00 T Baseline Week 13 Assessment Period I 0 mg/kg/day I 25 mg/kg/day ^ 1 0 0 mgkgday ! 250 mg/kg/day Recovery Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Revised Page DuPont-5386 FIGURE 7 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR MALE RATS 2000 0 mg/kg/day 25 mg/kg/day H 100 mgkgday 250 mg/kg/day Baseline Week 13 Assessment Period 478 Recovery Company Saniltaed. Does m l contato TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURE 8 MOTOR ACTIVITY ASSESSMENT: MEAN DURATION OF MOVEMENTS FOR FEMALE RATS Duration o f Movements (sec) 2000 1800 1600 1400 1200 1000 800 600 400 200 0 Baseline 0 mg/kg/day 25 mg/kg/day 100 mgkgday 250 mg/kg/day Week 13 Assessment Period 479 Recovery Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revised Page DuPont-5386 FIGURE 9 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR MALE RATS Number of Movements 900 800 700 600 500 ! 0 mg/kg/day ; 25 mg/kg/day H 100mgkgday 400 300 I200 100 0 Baseline Week 13 Assessment Period 480 tsc a cbi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Revised Page DuPont-5386 FIGURE 10 MOTOR ACTIVITY ASSESSMENT: MEAN NUMBER OF MOVEMENTS FOR FEMALE RATS 900 0 mg/kg/day 25 mg/kg/day 100mgkgday M 250 mg/kg/day Baseline Week 13 Assessment Period 481 Recovery Com pany S an itize d . D oes n t co n ta in TSCA OBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDICES m p a n y S a n itize d . Does not contain TSCA CBt 482 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX A ANALYTICAL DATA Cstttpany Sanitized. Does not contain TSCA CBI 483 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table I. Initial Homogeneity and Stability o f H-24516 in Dosing Suspensions Sample mg/mL H-24516 Type Nominal Measured Test Day 0 Homogeneity Control 0.00 n d (a ) Top M iddle B ottom 2.5 2.30 2.5 2.47 2.5 2.40 M e a n iB); 2 .3 9 + 0 .0 8 C.V. 3% Percent Nominal -- 92.0 98.8 96.0 (95.6% ) T op M iddle Bottom(c ) 10 8.97 10 10.2 10 14.0 M eanfX- 11-1+2.6 C.V. 24% 89.7 102.0 140.0 (111.0% ) T op M iddle B ottom 25 26.8 25 24.8 25 23.5 Mea(B); 25.01.6 C.V. 7% 107.2 99.2 94.0 (100.0% ) Stabilitv(D) 2.5 10 25 2.06 82.4 8.89 88.9 24.1 96.4 Test Day 6 Homogeneity Control T op M iddle B ottom 0.00 n d (a ) 10 9.26 10 9.58 10 9.23 M e a n W : 9.36+0.19 C. V. 2% -- 92.6 95.8 92.3 (93.6% ) Stability(D) 10 9.03 90.3 (A) Denotes not detected. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) Duplicate re-analysis o f original sample supports the original analysis and will not be reported. (D) Stability samples held 5 hours a room temperature. Company Sanitized. Does not contain TSCA CBi 484 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table II. Mixing and Stability Study o f H-24516 in Dosing Suspensions Sample Type mg/mL H-24516 Dose Volume Nominal Measured Homogeneity 7.5 mL/Kg Control 0.00 n d (a ) Percent Nominal -- T op M iddle Bottom 5.0 mL/Kg Control 3.33 2.88 3.33 2.54 3.33 2.67 M ea n iB); 2.70+0.2 C.V. 6 % 0.00 n d (a ) 86.5 76.3 80.2 (81.1% ) -- Top M iddle Bottom T op M iddle B ottom T op M iddle B ottom 5.0 4.53 5.0 4.25 5.0 4.39 M ean& ):4-390.14 C.V. 3 % 20.0 19.9 20.0 17.7 20.0 18.6 Afean(B); 18.7+1.1 c. v. 6 % 50.0 53.4 50.0 52.6 50.0 54.0 M e a n ^ h 53.4+0.7 C. V. 1 % 90.6 85.0 87.8 (87.8% ) 99.5 88.5 93.0 (93.5% ) 106.8 105.2 108.0 (106.8% ) Stability 7.5 mL/Kg 0-D ay Room T emperature 5-Hour Room T emperature 4 -D ay Refrigerated 3.33 2.70 3.33 2.66 3.33 2.94 3.33 2.88 M ean{C ).2.91+0.04 81.1 79.9 88.3 86.5 (87.4% ) C.V. 1% 4 -D a y R efrigkrated/5 Ho u r RT 3.33 2.74 82.3 (A) Denotes not detected. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f duplicate samples are based on measured concentration for each level. Company Saniffzed. Does not contain TSCA CBi 485 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table II. Mixing and Stability Study o f H-24516 in Dosing Suspensions (continued) Sample Type Dose Volume Stability 5.0 mL/Ke 0-D ay Room Temperature mg/mL H-24516 Nominal Measured 5.0 4.39 5-Hour Room T emperature 5.0 4.60 2-D ay Refrigerated 5.0 4.77 5.0 4,76 M ean )): 4-77+0.01 3-D ay Refrigerated 5.0 5.0 C.V. 0.2% 4.74 4,48 M eant): 4.61+0.2 4-D ay Refrigerated 4-D ay Refrigerated/5 Hour RT 5.0 5.0 C.V. 4% 4.81 4.85 Percent Nominal 87.8 92.0 95.4 95.2 (95.4% ) 94.8 89.6 (92.2% ) 96.1 97.1 0 -D ay Room T emperature 5-Hour Room T emperature 2-D ay Refrigerated 3-D ay Refrigerated 4-D ay Refrigerated 4-D ay Refrigerated/5 Hour RT 20.0 20.0 20.0 20.0 20.0 20.0 20.0 20.0 18.7 17.2 18.7 18.0 M ean '): TM -30.5 C.V. 3% 39.3 19,6 ; t W C ,D ) . 29.414 C.V. 47% 19.6 17.6 93.5 86.0 93.5 90.0 (91.5% ) 196.4 97.8 (147.0% ) 97.8 88.2 0-D ay Room Temperature 50.0 53.4 106.8 5-Hour Room T emperature 50.0 48.3 96.6 2-D ay R efrigerated 50.0 50.0 47.3 94.7 48.4 96.8 M ean'): 47.9+0.8 (95.8% ) 3-D a y Refrigerated 50.0 50.0 C. V. 2% 46.5 46.9 93.0 93.8 M e a n ); 46.7+0.3 (93.4% ) 4-D ay Refrigerated 50.0 C.V. 1% 48.9 97.8 4-D ay Refrigerated/5 Hour RT 50.0 47.9 95.7 A) Denotes not detected. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f duplicate samples are based on measured concentration for each level. (D) Result is the mean o f the duplicate re-analysis o f the original sample. Original analysis indicated aliquot error and will not be reported. Company Sanitized. Does not contain TSCA CBI 486 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Table 111. Final Homogeneity/Concentration Verification o f H-24516 in Dosing Suspensions Sample mg/mL H-24516 Percent Type Nominal Measured Nominal Test Day 49 Homogeneity C o n tro l 0.00 n d (a ) -- T op M id d l e B ottom T op M id d l e B ottom T op M id d l e B ottom 3.33 3.33 3.33 13.33 13.33 13.33 33.33 33.33 33.33 M ean^h M ean(^\M ean^h 2.71 2.99 3.42 3.04+0.4 C. V. 12 % 10.8 12.7 12,8 12.1+1.1 C.V. 9% 31.0 32.4 33,4 3 2 .3 1 .2 C.V. 4% 81.4 89.8 102.8 (91.3% ) 81.0 95.3 96.3 (90.8% ) 92.9 97.1 100.3 (96.8% ) Test Day 91 C ontrol Homogeneity T op M id d l e B ottom 0.00 n d (a ) 3.33 3.05 3.33 3.00 3.33 3.01 M ean(B \- 3.02+0.03 C. V. 1 % -- 91.6 90.1 90.4 (90.7% ) Concentration Verification 13.33 13.33 M ea n ic ): 12.8 12,2 12.50.4 C.V. 3% 96.0 91.5 (93.8% ) 33.33 32.7 98.1 33.33 32,3 96.6 M ean (c \- 32.50.3 (97.5% ) C.V. 1% (A) Denotes not detected. (B) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f top, middle, and bottom are based on measured concentration for each level. (C) The average measured concentration, average percent o f nominal (in parentheses), standard deviation, and coefficient o f variation o f duplicate samples arc based on measured concentration for each level. Company Sanitized. Does not contain TSCA CB1 487 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Figure 1 Representative Analytical Calibration Curve DuPont-5386 (a) (b) Concentration mg/mL (c) Figure 1: Calibration curve show ing linear fit (line) to replicate peak height ratio measurements (squares) for calibration solutions o f H-24516 diluted over a concentration range o f 0.0302 to 0.1511 mg/mL. [(a) Retention time = 3.5 minutes, (b) Retention = 4.17 minutes, (c) Retention time = 4.77 minutes.] C o m p a n y S a n itize d . Does not contain 488 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Figure 2 Representative High Performance Liquid Chromatography Chromatograms F1D1 B. (001212SR\002F0201 .D) pA 1 60 -1 Figure 2a: Representative GC chromatogram o f 0 mg/mL (control) sample with internal s t a n d a r d ^ P B B B j j ^ l J J J ^ J J j J P ^ I I J J P ^ t d d e d . Retention for H -24516 is approxim ately 3.5, 4.1, 4.7 minutes. Retention time for internal standard is approximately 3.9 minutes. FIDI B. (001212SR\008FQB01.D> pA 1 60 - 50 - 40 - Figure 2b: Representative GC chromatogram o f 2.5 mg/mL H -24516 dosing solution diluted to a nominal concentration o f 0.06 mg/mL. The measured concentration o f the representative solution is 2.51 mg/mL Company Sanitized. Does not contain TSCACB 489 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Figure 2 (continued) Representative High Performance Liquid Chromatography Chromatograms F1D1 8. (001212SR\004F0401.D) pA Tj 60 - 50 ~ 40 - 30 - X"T IO Jt20 10 - - ' ! ....... ' - - ' l ' ' I ' - ' ' l ......... .......... Q______________________________ 2______________________________ i.... .. _ ............... ............................6______________________________ 8________ Figure 2c: Representative GC chromatogram o f 0.0756 mg/mL H -24516 analytical reference solution. Company Sanitized. Does not contain TSCA CBI 490 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX B INDIVIDUAL DOSE VOLUMES (ML) Company Sanitized. Does not contain TSCA CBl 491 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES (ML) EXPLANATORY NOTES DuPont-5386 Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co housed. Dose volumes administered during the cohabitation and post-mating periods are documented in the study records. Day 89 Last day o f test substance administration for male and female rats designated for one-month and 3-month recovery periods. Day 90 Last day o f test substance administration for male rats designated for the 90day exposure period. Day 92 Last day o f test substance administration for female rats designated for the 90-day exposure period. Footnotes a. Due to error, data are missing. b. Animal may not have received total dose. c. Due to error, rat was dosed with vehicle only. d. On test day 18, all male rats and the first 11 female rats in the 25 mg/kg/day group received 37-39 mg/kg/day. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extrem is Company Sanitized. Does not contain TSCA CBl 492 I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUME Day 0 Day 1 Male, I - 0 mg/kg/day 643241 2.8 2.8 643300 2.4 2.4 643143 2.4 2.4 643205 2.6 2.6 643235 2.8 2.8 643288 2.5 2.5 643150 2.4 2.4 643189 2.5 2.5 643185 2.5 2.5 643210 2.5 2.5 643268 2.6 2.6 643232 2.6 2.6 643265 2.4 2.4 643239 2.7 2.7 643270 2.4 2.4 643148 2.5 2.5 643284 2.8 2.8 643229 2.4 2.4 643196 2.1 2.1 643176 2.5 2.5 643218 2.7 2.7 643207 2.4 2.4 643280 2.3 2.3 643271 2.6 2.6 643211 2.5 2.5 643163 2.7 2.7 643197 2.5 2.5 643242 2.4 2.4 643251 2.4 2.4 643155 2.4 2.4 643147 2 6 2.5 643276 2.8 2.8 643237 2.4 2.4 643226 2.5 2.5 643195 2.4 2.4 643246 3.0 3.0 643253 2.4 2.4 643262 2.5 2.5 643172 2.6 2.6 643303 2.3 2.3 643304 2.1 2.1 643162 2.3 2.3 643254 2.2 _ a 643145 2.5 a 643204 2.7 a Day 2 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 Day 3 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 Day 4 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 Day 5 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 Day 6 2.8 2.4 2.4 2.6 2.8 2.5 2.4 2.5 2.5 2.5 2.6 2.6 2.4 2.7 2.4 2.5 2.8 2.4 2.1 2.5 2.7 2.4 2.3 2.6 2.5 2.7 2.5 2.4 2.4 2.4 2.5 2.8 2.4 2.5 2.4 3.0 2.4 2.5 2.6 2.3 2.1 2.3 2.2 2.5 2.7 493 IS (mL) 7 Day 8 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 31 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3 .2 3.1 3.0 2.9 3.1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 DuPont-5386 9 Day 10 Day 11 35 30 29 31 35 31 29 32 32 30 32 31 29 34 29 30 34 28 26 30 31 29 28 32 31 34 32 31 30 29 3i 35 28 29 30 36 30 31 32 29 26 28 27 29 32 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3 .1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 3.5 3.0 2.9 3.1 3.5 3.1 2.9 3.2 3.2 3.0 3.2 3.1 2.9 3.4 2.9 3.0 3.4 2.8 2.6 3.0 3.1 2.9 2.8 3.2 3.1 3.4 3.2 3.1 3.0 2.9 3 .1 3.5 2.8 2.9 3.0 3.6 3.0 3.1 3.2 2.9 2.6 2.8 2.7 2.9 3.2 Company Sanitized. Does not contain TSCA CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, I - 0 rng/kg/day 643241 3.5 3.5 643300 3.0 3.0 643143 2.9 2.9 643205 3.1 3.1 643235 3.5 3.5 643288 3.1 3.1 643150 2.9 2.9 643189 3.2 3.2 643185 3.2 3.2 643210 3.0 3.0 643268 3.2 3.2 643232 3.1 3.1 643265 2.9 2.9 643239 3.4 3.4 643270 2.9 2.9 643148 3.0 3.0 643284 3.4 3.4 643229 2.8 2.8 643196 2.6 2.6 643176 3.0 3.0 643218 3.1 3.1 643207 2.9 2.9 643280 2.8 2.8 643271 3.2 3.2 643211 3.1 3.1 643163 3.4 3.4 643197 3.2 3.2 643242 3.1 3.1 643251 3.0 3.0 643155 2.9 2.9 643147 3 .1 3.1 643276 3.5 3.5 643237 2.8 2.8 643226 2.9 2.9 643195 3.0 3 .0 643246 3.6 3.6 643253 3.0 3.0 643262 3.1 3.1 643172 3.2 3.2 643303 2.9 2.9 643304 2.6 2.6 643162 2.8 2.8 643254 2.7 2.7 643145 2.9 2.9 643204 3.2 3.2 Day 14 4.1 3.5 3.4 3.6 4.1 3.6 3.4 3.8 3.8 3.5 3.8 3.4 3.4 3.8 3.4 3.5 3.9 3.2 3.0 3.5 3.6 3.3 3.4 3.8 3.5 3.9 3.6 3.6 3.5 3.5 3.6 4.2 3.2 3.4 3.5 4.3 3.5 3.7 3.7 3.4 3.0 3.3 3.1 3.3 3.7 Day 15 4.1 3.5 3.4 3.6 4.1 3.6 3.4 3.8 3.8 3.5 3.8 3.4 3.4 3.8 3.4 3.5 3.9 3.2 3.0 3.5 3.6 3.3 3.4 3.8 3.5 3.9 3.6 3.6 3.5 3.5 3.6 4.2 3.2 3.4 3.5 4.3 3.5 3.7 3.7 3.4 3.0 3.3 3.1 3 .3 3.7 INDIVIDUAL DOSE VOLUME Day 16 Day 17 Day 18 4.1 4.1 4.1 3.5 3.5 3.5 3.4 3.4 3.4 3.6 3.6 3.6 4.1 4.1 4.1 3.6 3.6 3.6 3.4 3.4 3.4 3.8 3.8 3.8 3 .8 3.8 3.8 3.5 3.5 3.5 3.8 3.8 3.8 3.4 3.4 3.4 3.4 3.4 3.4 3.8 3.8 3.8 3.4 3.4 3.4 3.5 3.5 3.5 3.9 3.9 3.9 3.2 3.2 3.2 3.0 3.0 3.0 3.5 3.5 3.5 3.6 3.6 3.6 3.3 3.3 3.3 3.4 3.4 3.4 3.8 3.8 3.8 3.5 3.5 3.5 3.9 3.9 3.9 3 .6 3.6 3.6 3.6 3.6 3.6 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 4.2 4.2 4.2 3.2 3.2 3.2 3.4 3.4 3.4 3 .5 3.5 3.5 4.3 4.3 4.3 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 3.4 3.4 3.4 3.0 3.0 3.0 3.3 3.3 3 .3 3.1 3.1 3.1 3.3 3.3 3.3 3.7 3.7 3.7 494 S (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 4.1 4.1 4.5 4.5 4.5 3.5 3.5 3.9 3.9 3.9 3.4 3.4 3.8 3.8 3.8 3.6 3.6 4.1 4.1 4.1 4.1 4.1 4.6 4.6 4.6 3.6 3.6 4.1 4.1 4.1 3.4 3.4 3.6 3.6 3.6 3.8 3.8 4.3 4.3 4.3 3.8 3.8 4.2 4 . 2 4.2 3.5 3.5 3.9 3.9 3.9 3.8 3.8 4.3 4.3 4.3 3.4 3.4 3.8 3.8 3.8 3.4 3.4 4.0 4.0 4.0 3.8 3.8 4.3 4.3 4.3 3.4 3.4 3.8 3.8 3.8 3.3 3.5 3.8 3.8 3.8 3.9 3.9 4.3 4.3 4.3 3.2 3.2 3.5 3.5 3.5 3.0 3.0 3.3 3.3 3.3 3.5 3.5 3 .9 3.9 3.9 3.6 3.6 4.0 4.0 4.0 3.3 3.3 3.6 3.6 3.6 3.4 3.4 3.8 3.8 3.8 3.8 3.8 4.3 4.3 4.3 3.5 3.5 3.9 3.9 3.9 3.9 3.9 4.4 4.4 4.4 3.6 3.6 4.2 4.2 4.2 3.6 3.6 4.0 4.0 4.0 3.5 3.5 3.9 3.9 3.9 3.5 3.5 3.9 3.9 3.9 3.6 3.6 4.0 4.0 4.0 4.2 4.2 4.7 4.7 4.7 3.2 3.2 3.6 3.6 3.6 3.4 3.4 3.7 3.7 3.7 3.5 3.5 3.8 3.8 3.8 4.3 4.3 4.7 4.7 4.7 3.5 3.5 4.0 4.0 4.0 3.7 3.7 4.2 4.2 4.2 3.7 3.7 4.3 4.3 4.3 3.4 3.4 3.9 3.9 3.9 3.0 3.0 3.4 3.4 3.4 3.3 3.3 3.7 3.7 3.7 3.1 3.1 3.3 3.3 3.3 3.3 3.3 3.7 3.7 3.7 3.7 3.7 4.1 4.1 4.1 Company Sanitized. Does not contain TSCAC ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 24 Day 25 Male, I - 0 mg/kg/day 643241 4.5 4.5 643300 3.9 3.9 643143 3.8 3.8 643205 4.1 4.1 643235 4.6 4.6 643288 4.1 4.1 643150 3.6 3.6 643189 4.3 4.3 643185 4.2 4.2 643210 3.9 3.9 643268 4.3 4.3 643232 3.8 3.8 643265 4.0 4.0 643239 4.3 4.3 643270 3.8 3.8 643148 3 .8 3.8 643284 4.3 4.3 643229 3.5 3.5 643196 3.3 3.3 643176 3.9 3.9 643218 4.0 4.0 643207 3.6 3.6 643280 3.8 3.8 643271 4.3 4.3 643211 3.9 3.9 643163 4.4 4.4 643197 4.2 4.2 643242 4.0 4.0 643251 3.9 3.9 643155 3.9 3.9 643147 4.0 4.0 643276 4.7 4.7 643237 3.6 3.6 643226 3.7 3.7 643195 3.8 3.8 643246 4.7 4.7 643253 4.0 4.0 643262 4.2 4.2 643172 4.3 4.3 643303 3.9 3.9 643304 3.4 3.4 643162 3.7 3.7 643254 3.3 3.3 643145 3.7 3.7 643204 4.1 4.1 Day 26 4.5 3.9 3.8 4.1 4.6 4.1 3.6 4.3 4.2 3.9 4.3 3.8 4.0 4.3 3.8 3.8 4.3 3.5 3.3 3.9 4.0 3.6 3.8 4.3 3 .9 4.4 4.2 4.0 3.9 3.9 4.0 4.7 3.6 3.7 3.8 4.7 4.0 4.2 4.3 3.9 3.4 3.7 3.3 3.7 4.1 Day 27 4.5 3.9 3.8 4.1 4.6 4.1 3.6 4.3 4.2 3.9 4.3 3.8 4.0 4.3 3.8 3.8 4.3 3.5 3.3 3.9 4.0 3.6 3.8 4.3 3.9 4.4 4.2 4.0 3.9 3.9 4.0 4.7 3.6 3.7 3.8 4.7 4.0 4.2 4.3 3.9 3.4 3.7 3.3 3.7 4.1 INDIVIDUAL DOSE VOLUMES Day 28 Day 29 Day 30 5.0 5.0 5.0 4.2 4.2 4.2 4.2 4.2 4.2 4.5 4.5 4.5 5.1 5.1 5.1 4.6 4.6 4.6 3.8 3.8 3.8 4.7 4.7 4.7 4.6 4.6 4.6 4.3 4.3 4.3 4.7 4.7 4.7 4.0 4.0 4.0 4.2 4.2 4.2 4.6 4.6 4.6 4.1 4.1 4.1 4.1 4.1 4.1 4.7 4.7 4.7 3.7 3.7 3.7 3.5 3.5 3.5 4.3 4.3 4.3 4.3 4.3 4.3 3.9 3.9 3.9 4.1 4.1 4.1 4.7 4.7 4.7 4.2 4.2 4.2 4.8 4.8 4.8 4.5 4.5 4.5 4.3 4.3 4.3 4.2 4.2 4.2 4.2 4.2 4.2 4.3 4.3 4.3 5.0 5.0 5.0 3.9 3.9 3.9 4.0 4.0 4.0 4.1 4.1 4.1 5.0 5.0 5.0 4.3 4.3 4.3 4.5 4.5 4.5 4.6 4.6 4.6 4.3 4.3 4.3 3.7 3.7 3.7 3.9 3.9 3.9 3.7 3.7 3.7 4.0 4.0 4.0 4.5 4.5 4.5 495 DuPont-5386 33 Day 34 Day 35 5.0 5.0 5.2 4.2 4.2 4.6 4.2 4.2 4.4 4.5 4.5 4.7 5.1 5.1 5.4 4.6 4.6 4.9 3.8 3.8 4.1 4.7 4.7 4.9 4.6 4.6 4.8 4.3 4.3 4.4 4.7 4.7 5.0 4.0 4.0 4.1 4.2 4.2 4.4 4.6 4.6 4.9 4.1 4.1 4.4 4.1 4.1 4.5 4.7 4.7 5.0 3.7 3.7 3.9 3.5 3.5 3.7 4.3 4.3 4.5 4.3 4.3 4.6 3.9 3.9 4.2 4.1 4.1 4.4 4.7 4.7 5.0 4.2 4.2 4.5 4.8 4.8 5.2 4.5 4.5 4.7 4.3 4.3 4.6 4.2 4.2 4.4 4.2 4.2 4.3 4.3 4.3 4.6 5.0 5.0 5.4 3.9 3.9 4.1 4.0 4.0 4.1 4.1 4.1 4.3 5.0 5.0 5.3 4.3 4.3 4.6 4.5 4.5 4.9 4.6 4.6 4.9 4.3 4.3 4.7 3.7 3.7 3.9 3.9 3.9 4.2 3.7 3.7 4.0 4.0 4.0 4.3 4.5 4.5 4.7 Com pany S an ifeed . Doe s noi co,, ,, ,,n ^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, i - 0 mg/kg/day 643241 5.2 5.2 643300 4.6 4.6 643143 4.4 4.4 643205 4.7 4.7 643235 5.4 5.4 643288 4.9 4.9 643150 4.1 4.1 643189 4.9 4.9 643185 4.8 4.8 643210 4.4 4.4 643268 5.0 5.0 643232 4.1 4.1 643265 4.4 4.4 643239 4.9 4.9 643270 4.4 4.4 643148 4.5 4.5 643284 5.0 5.0 643229 3.9 3.9 643196 3.7 3.7 643176 4.5 4.5 643218 4.6 4.6 643207 4.2 4.2 643280 4.4 4.4 643271 5.0 5.0 643211 4.5 4.5 643163 5.2 5.2 643197 4.7 4.7 643242 4.6 4.6 643251 4.4 4.4 643155 4.3 4.3 643147 4.6 4.6 643276 5.4 5.4 643237 4.1 4.1 643226 4.1 4.1 643195 4.3 4.3 643246 5.3 5.3 643253 4.6 4.6 643262 4.9 4.9 643172 4.9 4.9 643303 4.7 4.7 643304 3.9 3.9 643162 4.2 4.2 643254 4.0 4.0 643145 4.3 4.3 643204 4.7 4.7 Day 38 3.9 3.4 3.3 3.5 4.0 3.7 3.1 3.7 3.6 3.3 3.8 3.1 3.3 3.7 3.3 3 .3 3.8 2.9 2.8 3.4 3.4 3.2 3.3 3.7 3.3 3.9 3 .5 3.5 3.3 3.2 3.5 4.1 3.0 3.1 3.2 4.0 3.4 3.7 3.7 3.5 2.9 3 .1 3.0 3.3 3 .5 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 41 Day 42 3.9 3.9 3.9 4.1 3.4 3.4 3.4 3.6 3.3 3.3 3.3 3.5 3.5 3.5 3.5 3.8 4.0 4.0 4.0 4.3 3.7 3.7 3.7 3.9 3.1 3.1 3.1 3.2 3.7 3.7 3.7 3.9 3.6 3.6 3.6 3.8 3.3 3.3 3.3 3.5 3.8 3.8 3.8 3.9 3.1 3.1 3.1 3.2 3.3 3.3 3.3 3.6 3.7 3.7 3.7 3.9 3.3 3.3 3.3 3.5 3.3 3.3 3.3 3.4 3.8 3.8 3.8 4.0 2.9 2.9 2.9 3.1 2.8 2.8 2.8 3.0 3.4 3.4 3.4 3.6 3.4 3.4 3.4 3.6 3.2 3.2 3.2 3.3 3.3 3.3 3.3 3.5 3.7 3.7 3.7 4.0 3.3 3.3 3.3 3.5 3.9 3.9 3.9 4.1 3.5 3 .5 3 .5 3.7 3.5 3.5 3.5 3.7 3.3 3.3 3.3 3.4 3.2 3.2 3.2 3.4 3.5 3.5 3.5 3.7 4.1 4.1 4.1 4.2 3.0 3.0 3.0 3.2 3.1 3.1 3.1 3.3 3.2 3.2 3.2 3.5 4.0 4.0 4.0 4.2 3.4 3.4 3.4 3.7 3.7 3.7 3.7 3.9 3.7 3.7 3.7 3.9 3.5 3.5 3.5 3.8 2.9 2.9 2.9 3.1 3.1 3.1 3.1 3.2 3.0 3.0 3.0 3.2 3.3 3.3 3.3 3.4 3.5 3.5 3.5 3.7 Day 43 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3 .2 3.4 3.7 DuPont-5386 Day 44 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 Cm Vm y S m "b e g - "0t contain TSCA CBf  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3 .8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3 .5 4.2 3.7 3.9 3.9 3.8 3.1 3.2 3.2 3.4 3.7 Day 46 4.1 3.6 3.5 3.8 4.3 3.9 3.2 3.9 3.8 3.5 3.9 3.2 3.6 3.9 3.5 3.4 4.0 3.1 3.0 3.6 3.6 3.3 3.5 4.0 3.5 4.1 3.7 3.7 3.4 3.4 3.7 4.2 3.2 3.3 3.5 4.2 3.7 3.9 3.9 3.1 3.2 3.2 3.4 3 .7 CO PO Day 47 INDIVIDUAL DOSE VOLUMES Day 48 Day 49 4.1 4.1 4.3 3.6 3.6 3.8 3.5 3.5 3.6 3 .8 3.8 3.9 4.3 4.3 4.4 3.9 3.9 3.9 3.2 3.2 3.2 3.9 3.9 3.9 3.8 3.8 3.9 3.5 3.5 3.7 3.9 3.9 4.1 3.2 3.2 3.4 3.6 3.6 3.7 3.9 3.9 4.1 3.5 3.5 3.6 3.4 3.4 3.6 4.0 4.0 4.2 3.1 3.1 3.2 3.0 3.0 3.1 3.6 3.6 3.7 3.6 3.6 3.8 3.3 3.3 3.4 3.5 3.5 3.7 4.0 4.0 4.2 3.5 3.5 3.7 4.1 4.1 4.3 3.7 3.7 3.9 3.7 3.7 3.9 3.4 3.4 3.6 3.4 3.4 3.7 3.7 3.7 3.8 4.2 4.2 4.5 3.2 3.2 3.3 3.3 3.3 3.6 3.5 3.5 3.6 4.2 4.2 4.3 3.7 3.7 3.8 3.9 3.9 4.1 3.9 3.9 4.0 3.8 3.8 4.0 3.1 3.1 3.3 3.2 3.2 3.3 3.2 3.2 3.3 3.4 3.4 3.6 3.7 3.7 GJ CO 497 (mL) 50 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3 .3 3.6 3.8 Day 51 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4 .3 3.9 3.9 3.6 3 .7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 Day 52 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 DuPont-5386 Day 53 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 Company Sanitized Poes not contain Ts c a c b I )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Male, I -- 0 mg/kg/day 543241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3 .3 3 .3 3 .3 3.6 3.8 Day 55 4.3 3.8 3.6 3.9 4.4 3.9 3.2 3.9 3.9 3.7 4.1 3.4 3.7 4.1 3.6 3.6 4.2 3.2 3.1 3.7 3.8 3.4 3.7 4.2 3.7 4.3 3.9 3.9 3.6 3.7 3.8 4.5 3.3 3.6 3.6 4.3 3.8 4.1 4.0 4.0 3.3 3.3 3.3 3.6 3.8 Day 56 INDIVIDUAL DOSE VOLUMES Day 57 Day 58 4.4 4.4 4.4 4.0 4.0 4.0 3.7 3.7 3.7 4.0 4.0 4.0 4.5 4.5 4.5 4.1 4.1 4.1 3.3 3.3 3.3 4.1 4.1 4.1 4.0 4.0 4.0 3.7 3.7 3.7 4.2 4.2 4.2 3.4 3.4 3.4 3.7 3.7 3.7 4.2 4.2 4.2 3.7 3.7 3.7 3.7 3.7 3.7 4.3 4.3 4.3 3.3 3.3 3.3 3.2 3.2 3.2 3.8 3.8 3.8 4.0 4.0 4.0 3.5 3.5 3.5 3.9 3.9 3.9 4.4 4.4 4.4 3.8 3.8 3.8 4.5 4.5 4.5 4.0 4.0 4.0 4.1 4.1 4.1 3.7 3.7 3.7 4.0 4.0 4.0 4.0 4.0 4.0 4.7 4.7 4.7 3.5 3.5 3.5 3.7 3.7 3.7 3.8 3.8 3.8 4.4 4.4 4.4 4.0 4.0 4.0 4.2 4.2 4.2 4.3 4.3 4.3 4.1 4.1 4.1 3.4 3.4 3.4 3.1 3.1 3.1 3.4 3.4 3.4 3.6 3.6 3.6 3.9 3.9 3.9 498 I (mL) 59 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 Day 60 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3 .1 3.4 3.6 3.9 Day 61 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 DuPont-5386 Day 62 4.4 4.0 3.7 4.0 4.5 4.1 3.3 4.1 4.0 3.7 4.2 3.4 3.7 4.2 3.7 3.7 4.3 3.3 3.2 3.8 4.0 3.5 3.9 4.4 3.8 4.5 4.0 4.1 3.7 4.0 4.0 4.7 3.5 3.7 3.8 4.4 4.0 4.2 4.3 4.1 3.4 3.1 3.4 3.6 3.9 c o n p m y S anitized, D o e , not contain TSCA CB )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL DOSE VOLUMES Day 63 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 64 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 65 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 66 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 67 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 499 (mL) 68 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 69 4.6 4.2 3.7 4.1 4.7 4.2 3.5 4.3 4.2 3.8 4.2 3.6 3.7 4.4 3.8 3.8 4.5 3.4 3.3 3.9 4.1 3.6 4.0 4.6 3.9 4.6 4.2 4.3 3.9 4.1 4.0 4.9 3.6 3.9 3.9 4.6 4.1 4.3 4.4 4.3 3.5 3.0 3.5 3.7 4.1 Day 70 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 DuPont-5386 Day 71 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 Company Sanitized. Does not contain TSCA CBt I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 72 Male, I -- 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 D.x 3.7 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3.1 3.6 3.8 4.2 ay 73 4.7 4.3 3.8 4.2 4.7 4.4 3.6 4.4 4.2 4.0 4.4 3.7 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 37 4.0 4.1 4.8 4.3 4.4 4.6 4.3 3.6 3 .1 3.6 3.8 4.2 Day 74 INDIVIDUAL DOSE VOLUMES Day 75 Day 76 4.7 4.7 4.7 4.3 4.3 4.3 3.8 3.8 3.8 4.2 4.2 4.2 4.7 4.7 4.7 4.4 4.4 4.4 3.6 3.6 3.6 4.4 4.4 4.4 4.2 4.2 4.2 4.0 4.0 4.0 4.4 4.4 4.4 3.7 3.7 3.7 3.8 3.8 3.8 4.5 3.8 3.8 4.7 3.5 3.4 4.0 4.2 3.8 4.2 4.7 4.0 4.8 4.3 4.4 3.9 4.3 4.2 5.1 3.7 3.7 3.7 4.0 4.0 4.0 4.1 4.1 4.1 4.8 4.8 4.8 4.3 4.3 4.3 4.4 4.4 4.4 4.6 4.6 4.6 4.3 4.3 4.3 3.6 3.6 3 .6 3.1 3.1 3.1 3.6 3.8 3.8 3.8 4.2 4.2 4.2 500 (mL) 77 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 Day 78 Day 79 4.7 b 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 DuPont-5386 Day 80 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 3.8 3.8 3.8 4.1 4.1 4.1 4.1 4.1 4.1 4.1 4.1 4.8 4.8 4.8 4.8 4.3 4.3 4.3 4.3 4.5 4.5 4.5 4.5 4.7 4.7 4.7 4.7 4.5 4.5 4.5 4.5 3.7 3.7 3.7 3.7 2.8 2.8 2.8 3.7 3.7 3.7 3.7 4.2 4.2 4.2 4.2 Company Sanitized. Dom oot coiaio TSCA CEI CO CM i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 81 Male, I - 0 oeg /kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 6432-76 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3 .8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 Day 82 4.7 4.4 3.9 4.3 4.8 4.5 3.6 4.5 4.4 4.0 4.3 3.8 3.8 3.8 4.1 4.1 4.8 4.3 4.5 4.7 4.5 3.7 2.8 3.7 4.2 Day 83 INDIVIDUAL DOSE VOLUMES Day 84 Day 85 4.7 4.8 4.8 4.4 4.5 4.5 3.9 3.9 3 .9 4.3 4.4 4.4 4.8 4.9 4.9 4.5 4.6 4.6 3.6 3.6 3.6 4.5 4.6 4.6 4.4 4.5 4.5 4.0 4.1 4.1 4.3 4.4 4.4 3.8 3.9 3.9 3.8 3.8 3.8 3.8 3.8 3.8 4.1 4.1 4.1 4.1 4.2 4.2 4.8 4.8 4.8 4.3 4.5 4.5 4.5 4.5 4.5 4.7 4.7 4.7 4.5 4.6 4.6 3.7 3.8 3.8 2.8 3.0 3.0 3.7 3.9 3.9 4.2 4.4 4.4 501 (mL) 86 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 Day 87 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 Day 88 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 DuPont-5386 Day 89 4.8 4.5 3.9 4.4 4.9 4.6 3.6 4.6 4.5 4.1 4.4 3.9 3.8 3.8 3.8 3.8 3.8 4.1 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.8 4.8 4.8 4.8 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4.5 4.7 4.7 4.7 4.7 4.6 4.6 4.6 4.6 3.8 3 .8 3.8 3.8 3.0 3.0 3.0 3.0 3.9 3.9 3.9 3.9 4.4 4.4 4.4 4.4 Company Sanitized. Does not contain TSC A CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 90 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 64327 6 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 4.8 4.5 3.9 4.4 5.0 4.5 3.7 4.7 4.6 4.5 INDIVIDUAL DOSE VOLUMES (mL) 502 DuPont-5386 'ompany Sanitized. Does not contain TSCA CBt )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Male, Ii 1 - 2 5 mg/kg/day 643173 2.4 2.4 643290 2.1 2.1 643272 2.3 2.3 643292 2.5 2.5 643228 2.8 2.8 643308 2.6 2.6 643264 2.7 2.7 643240 2.5 2.5 643180 2.4 2.4 643179 2.6 2.6 643202 2.3 2.3 643310 2.6 2.6 643306 2.2 2.2 643305 2.7 2.7 643293 2.5 2.5 643287 2.1 2.1 643188 2.6 2.6 643230 2.6 2.6 643170 2.6 2.6 643144 1.9 1.9 643277 2.5 2.5 643214 2.6 2.6 643261 2.6 2.6 643166 2.3 2.3 643153 2.4 2.4 643177 2.4 2.4 643198 2.7 2.7 643291 2.6 2.6 643184 2.4 2.4 643167 2.5 2.5 643223 2.6 2.6 643233 2.4 2.4 643183 2.6 2.6 643219 2.7 2.7 643263 2.3 2.3 Day 2 2.4 2.1 2.3 2.5 2.8 2.6 2.7 2.5 2.4 2.6 2.3 2.6 2.2 2.7 2.5 2.1 2.6 2.6 2.6 1.9 2.5 2.6 2.6 2.3 2.4 2.4 2.7 2.6 2.4 2.5 2.6 2.4 2.6 2.7 2.3 Day 3 INDIVIDUAL DOSE VOLUMES Day 4 Day 5 Day 6 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.5 2.5 2.5 2.5 2.8 2.8 2.8 2.8 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.3 c 2.3 2.3 2.3 2.6 c 2.6 2.6 2.6 2.2 c 2.2 2.2 2.2 2.7 c 2.7 2.7 2.7 2.5 c 2.5 2.5 2.5 2.1 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 1.9 1.9 1.9 1.9 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.3 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.7 2.7 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.3 2.3 2.3 2.3 503 ! DuPont-5386 Day 8 Day 9 Day 10 Day 11 0 3.0 3.0 3.0 3.0 7 2.7 2.7 2.7 2.7 8 2.8 2.8 2.8 2.8 0 3.0 3.0 3.0 3.0 5 3.5 3.5 3.5 3.5 3 3.3 3.3 3.3 3.3 3 3.3 3.3 3.3 3.3 0 3.0 3.0 3.0 3.0 0 3.0 3.0 3.0 3.0 1 3.1 3.1 3.1 3.1 8 2.8 2.8 2.8 2.8 2 3.2 3.2 3.2 3.2 6 2.6 2.6 2.6 2.6 2 3.2 3.2 3.2 3.2 0 3.0 3.0 3.0 3.0 6 2.6 2.6 2.6 2.6 3 3.3 3.3 3.3 3.3 1 3.1 3.1 3.1 3.1 2 3.2 3.2 3.2 3.2 4 2.4 2.4 2.4 2.4 1 3.1 3.1 3.1 3.1 3 3.3 3.3 3.3 3.3 2 3.2 3.2 3.2 3.2 8 2.8 2.8 2.8 2.8 9 2.9 2.9 2.9 2.9 1 3.1 3.1 3.1 3.1 4 3.4 3.4 3.4 3.4 2 3.2 3.2 3.2 3.2 0 3.0 3.0 3.0 3.0 2 3.2 3.2 3.2 3.2 1 3.1 3.1 3.1 3.1 9 2.9 2.9 2.9 2.9 2 3.2 3.2 3.2 3.2 3 3.3 3.3 3.3 3.3 8 2.8 2.8 2.8 CO CN Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, III - 25 mg/kg/day 643173 3.0 3.0 643290 2.7 2.7 643272 2.8 2.8 643292 3.0 3.0 643228 3.5 3.5 643308 3.3 3.3 643264 3.3 3.3 643240 3.0 3.0 643180 3.0 3.0 643179 3.1 3.1 643202 2.8 2.8 643310 3.2 3.2 643306 2.6 2.6 643305 3.2 3.2 643293 3.0 3.0 643287 2.6 2.6 643188 3.3 3 .3 643230 3.1 3.1 643170 3.2 3.2 643144 2.4 2.4 643277 3.1 3.1 643214 3.3 3.3 643261 3.2 3.2 643166 2.8 2.8 643153 2.9 2.9 643177 3 .1 3.1 643198 3.4 3.4 643291 3.2 3.2 643184 3.0 3.0 643167 3.2 3.2 643223 3 .1 3.1 643233 2.9 2.9 643183 3.2 3.2 643219 3 .3 3.3 643263 2.8 2.8 Day 14 3.5 3.2 3.3 3.5 4.1 3.9 3.9 3.6 3.6 3.7 3.3 3.6 3.0 3.7 3.5 3.0 4.0 3.5 3.7 2.9 3.7 3.7 3 .8 3.4 3.5 3.6 4.0 3.8 3.4 3.8 3.6 3.3 3.7 3.8 3 .2 Day 15 3 .5 3 .2 3 .3 3 .5 4 .1 3 .9 3 .9 3 .6 3 .6 3 .7 3 .3 3 .6 3 .0 3 .7 3 .5 3 .0 4 .0 3 .5 3 .7 2 .9 3 .7 3 .7 3 .8 3 .4 3 .5 3 .6 4 .0 33 .8 .4 3 .8 3 .6 3 .3 3 .7 3 .8 3 .2 INDIVIDUAL DOSE VOLUMES Day 16 Day 17 Day 18d 3.5 3.5 3.5 3.2 3.2 3.2 3.3 3.3 3.3 3.5 3.5 3.5 4.1 4.1 4.1 3.9 3.9 3.9 3.9 3.9 3.9 3.6 3.6 3.6 3.6 3.6 3.6 3.7 3.7 3.7 3.3 3.3 3.3 3.6 3.6 3.6 3.0 3.0 3.0 3.7 3.7 3.7 3.5 3.5 3.5 3.0 3.0 3.0 4.0 4.0 4.0 3.5 3.5 3 .5 3.7 3.7 3.7 2.9 2.9 2.9 3.7 3.7 3.7 3.7 3.7 3.7 3 .8 3 .8 3.8 3.4 3.4 3.4 3.5 3.5 3.5 3.6 3.6 3.6 4.0 4.0 3.8 3.8 3.8 3.4 3.4 3.4 3.8 3.8 3.8 3.6 3.6 3.6 3.3 3.3 3.3 3.7 3.7 3.7 3.8 3.8 3.8 3.2 3.2 3.2 o O' (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 3.5 3.5 3 8 3.8 3.8 3.2 3.2 3 6 3.6 3.6 3.3 3.3 3 5 3.5 3.5 3.5 3.5 3 9 3.9 3.9 4.1 4.1 4 5 4.5 4.5 3.9 3.9 4 2 4.2 4.2 3.9 3.9 4 3 4.3 4.3 3.6 3.6 3 8 3.8 3.8 3.6 3.6 4 0 4.0 4.0 3.7 3.7 4 1 4.1 4.1 3.3 3.3 3 6 3.6 3.6 3.6 3.6 4 1 4.1 4.1 3.0 3.0 3 3 3.3 3.3 3.7 3.7 4 0 4.0 4.0 3.5 3.5 3 9 3.9 3.9 3.0 3.0 3 4 3.4 3.4 4.0 4.0 4 4 4.4 4.4 3.5 3.5 3 8 3.8 3.8 3.7 3.7 4 1 4.1 4.1 2.9 2.9 3 3 3.3 3.3 3.7 3.7 4 2 4.2 4.2 3.7 3.7 4 2 4.2 4.2 3.8 3.8 4 2 4.2 4.2 3.4 3.4 3 7 3.7 3.7 3.5 3.5 3 8 3.8 3.8 3.6 3.6 4 0 4.0 4.0 4.0 4.0 4 .5 4.5 4.5 3.8 3.8 4 2 4.2 4.2 3.4 3.4 3 7 3.7 3.7 3.8 3.8 4 2 4.2 4.2 3.6 3.6 Q 3.9 3.9 3.3 3.3 3 6 3.6 3.6 3.7 3.7 4 0 4.0 4.0 3.8 3.8 4 2 4.2 4.2 3.2 3.2 3 6 3.6 3.6 Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, III - 25 mg/kg/day 643173 3.8 3.8 643290 3.6 3.6 643272 3.5 3.5 643292 3.9 3.9 643228 4.5 4.5 643308 4.2 4.2 643264 4.3 4.3 643240 3.8 3.8 643180 4.0 4.0 643179 4.1 4.1 643202 3.6 3.6 643310 4.1 4.1 643306 3 .3 3.3 643305 4.0 4.0 643293 3.9 3.9 643287 3.4 3.4 643188 4.4 4.4 643230 3.8 3.8 643170 4.1 4.1 643144 3.3 3.3 643277 4.2 4.2 643214 4.2 4.2 643261 4.2 4.2 643166 3.7 3.7 643153 3.8 3.8 643177 4.0 4.0 643198 4.5 4.5 643291 4 .2 4.2 643184 3.7 3.7 643167 4.2 4.2 643223 3.9 3.9 643233 3.6 3.6 643183 r .A n V 643219 4.2 4.2 643263 3.6 3.6 Day 26 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 Day 27 3.8 3.6 3.5 3.9 4.5 4.2 4.3 3.8 4.0 4.1 3.6 4.1 3.3 4.0 3.9 3.4 4.4 3.8 4.1 3.3 4.2 4.2 4.2 3.7 3.8 4.0 4.5 4.2 3.7 4.2 3.9 3.6 4.0 4.2 3.6 INDIVIDUAL DOSE VOLUM] Day 28 Day 29 Day 30 4.2 4.2 4.2 4.0 4.0 4.0 3.9 3.9 3.9 4.2 4.2 4.2 4.9 4.9 4.9 4.6 4.6 4.6 4.7 4.7 4.7 4.1 4.1 4.1 4.4 4.4 4.4 4.4 4.4 4.4 3.8 3.8 3.8 4.5 4.5 4.5 3.7 3.7 3.7 4.2 4.2 4.2 4.2 4.2 4.2 3.7 3.7 3.7 4.8 4.8 4.8 4.1 4.1 4.1 4.5 4.5 4.5 3.7 3.7 3.7 4.6 4.6 4.6 4.6 4.6 4.6 4.5 4.5 4.5 4.1 4.1 4.1 4.2 4.2 4.2 4.4 4.4 4.4 4.9 4.9 4.9 4.6 4.6 4.6 3.8 3.8 3.8 4.5 4.5 4.5 4.2 4.2 4.2 3.8 3.8 3.8 4.4 4.4 4.4 4.6 4.6 4.6 3.9 3.9 3.9 505 i 3S (mL) Day 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 4.2 4.2 4.2 4.2 4.7 4.0 4.0 4.0 4.0 4.3 3.9 3.9 3.9 3.9 4.1 4.2 4.2 4.2 4.2 4.6 4.9 4.9 4.9 4.9 5.4 4.6 4.6 4.6 4.6 5.Q 4.7 4.7 4.7 4.7 5.0 4.1 4.1 4.1 4.1 4.3 4.4 4.4 4.4 4.4 4.8 4.4 4.4 4.4 4.4 4.6 3.8 3.8 3.8 3.8 4.1 4.5 4.5 4.5 4.5 4.8 3.7 3.7 3.7 3.7 3.9 4.2 4.2 4.2 4.2 4.6 4.2 4.2 4.2 4.2 4.6 3.7 3.7 3.7 3.7 4.0 4.8 4.8 4.8 4.8 5.1 4.1 4.1 4.1 4.1 4.3 4.5 4.5 4.5 4.5 4.8 3.7 3.7 3.7 3.7 3.9 4.6 4.6 4.6 4.6 4.9 4.6 4.6 4.6 4.6 4.9 4.5 4.5 4.5 4.5 4.9 4.1 4.1 4.1 4.1 4.4 4.2 4.2 4.2 4.2 4.5 4.4 4.4 4.4 4.4 4.7 4.9 4.9 4.9 4.9 5.2 4.6 4.6 4.6 4.6 4.9 3.8 3.8 3.8 3.8 4.0 4.5 4.5 4.5 4.5 4.9 4.2 4.2 4.2 4.2 4.4 3.8 3.8 3.8 3.8 4.1 4.4 4.4 4.4 4.4 4,8 4.6 4.6 4.6 4.6 4.9 3.9 3.9 3.9 3.9 4.2 ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, III - 25 mg/kg/day 643173 4.7 4.7 643290 4.3 4.3 643272 4.1 4.1 643292 4.6 4.6 643228 5.4 5.4 643308 5.0 5.0 643264 5.0 5.0 643240 4.3 4.3 643180 4.8 4.8 643179 4.6 4.6 643202 4.1 4.1 643310 4.8 4.8 643306 3.9 3.9 643305 4.6 4.6 643293 4.6 4.6 643287 4.0 4.0 643188 5.1 5.1 643230 4.3 4.3 643170 4.8 4.8 643144 3.9 3.9 643277 4.9 4.9 643214 4.9 4.9 643261 4.9 4.9 643166 4.4 4.4 643153 4.5 4.5 643177 4.7 4.7 643198 5.2 5.2 643291 4.9 4.9 643184 4.0 4.0 643167 4.9 4.9 643223 4.4 4.4 643233 4.1 4.1 643183 4.8 4.8 643219 4.9 4.9 643263 4.2 4.2 Day 38 3.5 3.2 3.1 3.4 4.1 3.7 3.8 3.3 3.6 3.5 3.1 3.6 2.9 3.4 3.5 3.0 3.8 3.3 3.6 2.9 3.7 3.7 3.7 3.3 3.4 3.6 3.9 3.7 3.0 3.7 3.3 3.1 3.6 3.7 3.1 INDIVIDUAL DOSE VOLUMES (mL) ay 39 Day 40 Day 41 Day 42 3.5 3.5 3.5 3.6 3.2 3.2 3.2 3.5 3.1 3.1 3.1 3.3 3.4 3.4 3.4 3.6 4.1 4.1 4.1 4.2 3.7 3.7 3.7 3.9 3.8 3.8 3.8 4.0 3.3 3.3 3.3 3.3 3.6 3.6 3.6 3.8 3.5 3.5 3.5 3.6 3.1 3.1 3.1 3.2 3.6 3.6 3.6 3.7 2.9 2.9 2.9 3.1 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.6 3.0 3.0 3.0 3.1 3.8 3.8 3.8 3.9 3.3 3.3 3.3 3.3 3.6 3.6 3.6 3.7 2.9 2.9 2.9 3.1 3.7 3.7 3.7 3.9 3.7 3.7 3.7 3.8 3.7 3.7 3.7 3.8 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.5 3.6 3.6 3.6 3.7 3.9 3.9 3.9 4.0 3.7 3.7 3.7 3.9 3.0 3.0 3.0 3.1 3.7 3.7 3.7 3 .8 3.3 3.3 3.3 3.5 3.1 3.1 3.1 3.2 3.6 3.6 3.6 3.8 3.7 3 .7 3.7 3.8 3 .1 3.1 3.1 3.2 Day 43 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3 .1 3.5 3.6 3.1 3.9 3.3 3.7 3 .1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 DuPont-5386 Day 44 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3.8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3.8 3.5 3.2 3.8 3.8 3.2 Company Sanitized. Doe. not contain TSCACBI 506 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Day 46 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3 .8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3.1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3 .8 3.5 3.2 3 .8 3.8 3.2 3.6 3.5 3.3 3.6 4.2 3.9 4.0 3.3 3 .8 3.6 3.2 3.7 3.1 3.5 3.6 3.1 3.9 3.3 3.7 3 .1 3.9 3.8 3.8 3.4 3.5 3.7 4.0 3.9 3.1 3 .8 3.5 3.2 3.8 3.8 3.2 Day 47 INDIVIDUAL DOSE VOLUMES Day 48 Day 49 3.6 3.6 3.7 3.5 3.5 3.5 3.3 3.3 3.3 3.6 3.6 3.7 4.2 4.2 4.3 3.9 3.9 4.0 4.0 4.0 4.0 3.3 3.3 3.3 3.8 3.8 3.9 3.6 3.6 3.6 3.2 3.2 3.4 3.7 3.7 3.8 3.1 3.1 3.1 3.5 3.5 3.7 3.6 3.6 3.7 3.1 3.1 3.2 3.9 3.9 4.1 3.3 3.3 3.5 3.7 3.7 3.8 3.1 3.1 3.2 3.9 3.9 4.0 3.8 3.8 3.8 3.8 3.8 3.9 3.4 3.4 3.6 3.5 3.5 3.5 3.7 3.7 3.9 4.0 4.0 4.2 3.9 3.9 4.0 3.1 3 .1 3.2 3.8 3.8 3 .8 3.5 3.5 3.6 3.2 3.2 3.2 3.8 3.8 4.0 3.8 3.8 4.0 3.2 3.2 3.4 507 (mL) 50 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Day 51 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Day 52 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3 .8 3.6 3.2 4.0 4.0 3.4 DuPont-5386 Day 53 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Company Sanitized. Does not contain T SCA CBi  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, III -- 25 mg /kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3 .9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3 .9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 3.7 3.5 3.3 3.7 4.3 4.0 4.0 3.3 3.9 3.6 3.4 3.8 3.1 3.7 3.7 3.2 4.1 3.5 3.8 3.2 4.0 3.8 3.9 3.6 3.5 3.9 4.2 4.0 3.2 3.8 3.6 3.2 4.0 4.0 3.4 Day 56 INDIVIDUAL DOSE VOLUMES Day 57 Day 58 3.8 3.8 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.8 3.8 3.8 4.5 4.5 4.5 4.1 4.1 4.1 4.2 4.2 4.2 3.4 3.4 3.4 4.0 4.0 4.0 3.7 3.7 3.7 3.3 3.3 3.3 3.9 3.9 3.9 3.2 3.2 3.2 3.7 3.7 3.7 3.9 3.9 3.9 3.3 3.3 3.3 4.4 4.4 4.4 3.6 3.6 3.6 3.9 3.9 3.9 3.3 3.3 3.3 4.1 4.1 4.1 4.0 4.0 4.0 4.1 4.1 4.1 3.8 3.8 3.8 3.7 3.7 3.7 4.0 4.0 4.0 4.4 4.4 4.4 4.1 4.1 4.1 3.3 3.3 3.3 3.9 3.9 3.9 3.7 3.7 3.7 2.9 2.9 2.9 4.1 4.1 4.1 4.1 4.1 4.1 3.5 3.5 3 .5 508 (mL) 59 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 Day 60 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 Day 61 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 DuPont-5386 Day 62 3.8 3.8 3.4 3.8 4.5 4.1 4.2 3.4 4.0 3.7 3.3 3.9 3.2 3.7 3.9 3.3 4.4 3.6 3.9 3.3 4.1 4.0 4.1 3.8 3.7 4.0 4.4 4.1 3.3 3.9 3.7 2.9 4.1 4.1 3.5 Company Sanitized. Does not contain TSCA CB! ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 63 Day 64 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3 .3 4.2 4.3 3.6 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 4.2 4.3 3.6 Day 65 INDIVIDUAL DOSE VOLUMES Day 66 Day 67 3.9 3.9 3.9 3.9 3.9 3.9 3.7 3.7 3.7 3.9 3.9 3.9 4.7 4.7 4.7 4.2 4.2 4.2 4.4 4.4 4.4 3.5 3.5 3.5 4.2 4.2 4.2 3.7 3.7 3.7 3.4 3.4 3.4 4.0 4.0 4.0 3.2 3.2 3.2 3.8 3.8 3.8 4.1 4.1 4.1 3.4 3.4 3.4 4.5 4.5 4.5 3.7 3.7 3.7 4.1 4.1 4.1 3.4 3.4 3.4 4.4 4.4 4.4 4.1 4.1 4.1 4.3 4.3 4.3 3.9 3.9 3.9 3.8 3.8 3.8 4.1 4.1 4.1 4.4 4.4 4.4 4.3 4.3 4.3 3.2 3.2 3.2 4.0 4.0 4.0 3.8 3.8 3.8 3.3 3.3 3.3 4.2 4.2 4 2 4.3 4.3 4.3 3.6 3.6 3.6 509 (mL) Day 68 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 4.2 4.3 3.6 Day 69 3.9 3.9 3.7 3.9 4.7 4.2 4.4 3.5 4.2 3.7 3.4 4.0 3.2 3.8 4.1 3.4 4.5 3.7 4.1 3.4 4.4 4.1 4.3 3.9 3.8 4.1 4.4 4.3 3.2 4.0 3.8 3.3 A . O. 4.3 3.6 Day 70 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4 .1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 DuPont-5386 Day 71 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 Company Sanitized. Dees nol contain TSCA ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 72 Day 73 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 4.0 4.0 3.8 4.0 4.8 4.4 4.5 3.6 4.1 3.9 3.4 4.2 3.3 4.0 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 Day 74 INDIVIDUAL DOSE VOLUMES Day 75 Day 76 4.0 4.0 4.0 4.0 4.0 4.0 3.8 3.8 3.8 4.0 4.0 4.0 4.8 4.8 4.8 4.4 4.4 4.4 4.5 4.5 4.5 3.6 3.6 3.6 4.1 4.1 4.1 3.9 3.9. 3.9 3.4 3.4 3 .4 4.2 4.2 4.2 3.3 3.3 3.3 4.0 4.0 4.0 4.2 4.2 4.2 3.5 4.6 3.7 4.2 3.6 4.5 4.2 4.4 4.1 3.9 4.2 4.5 4.4 3.3 4.2 3.9 3.5 4.3 4.4 3.7 510 (inL) 77 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 Day 78 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 Day 79 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 DuPont-5386 Day 80 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 Company Sanitized. Does not contain TSCACBI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 81 Day 82 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3.3 4.0 4.1 4.1 4.1 3.9 4.0 5.0 4.5 4.7 3.7 4.2 3.9 3.5 4.1 3 .3 4.0 4.1 Day 83 INDIVIDUAL DOSE VOLUMES Day 84 Day 85 4.1 4.1 4.1 4.1 4.2 4.2 3.9 4.0 4.0 4.0 4.0 4.0 5.0 5.1 5.1 4.5 4.7 4.7 4.7 4.8 4.8 3.7 3.7 3.7 4.2 4.3 4.3 3.9 4.1 4.1 3.5 3.5 3.5 4.1 4.2 4.2 3.3 3.5 3.5 4.0 4.1 4.1 4.1 4.2 4.2 511 (mL) 86 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 Day 87 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 Day 88 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 DuPont-5386 Day 89 4.1 4.2 4.0 4.0 5.1 4.7 4.8 3.7 4.3 4.1 3.5 4.2 3.5 4.1 4.2 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 90 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 3.9 4.3 4.1 4.1 5.2 4.7 4.9 3.8 4.3 4.1 INDIVIDUAL DOSE VOLUMES (mL) DuPont-5386 Company Sanilfced. Does no, certain TSCA CB, ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Kale, V - 100 mg/kg/day 643250 2.3 2.3 643243 2.3 2.3 643311 2.4 2.4 643318 2.6 2.6 643247 2.8 2.8 643175 2.6 2 . 6 643314 2.6 2.6 643275 2.7 2.7 643257 2.4 2.4 643224 2.5 2 . 5 643169 2.3 2.3 643159 2.7 2.7 643286 2.1 2.1 643181 2.8 2.8 643206 2.4 2.4 643313 2 . 1 2.1 643182 2.5 2.5 643146 2.8 2 . 8 643312 2.4 2.4 643199 2.4 2.4 643267 2.5 2 . 5 643216 2.7 2.7 643244 2.5 2.5 643245 2.3 2.3 643301 2.6 2 . 6 643200 2.4 2.4 643255 2.6 2.6 643157 2.4 2.4 643238 2 . 6 2.6 643227 2.6 2 . 6 643164 2.5 2.5 643154 2.4 2 . 4 643156 2.7 2.7 643208 2.5 2.5 643190 2.7 2.7 Day 2 2.3 2 .3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2.7 2.5 2.7 Day 3 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2 .4 27 2.5 2.7 INDIVIDUAL DOSE VOLUMES Day 4 Day 5 Day 6 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 2n 2.5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 "> . ni 2 .5 2.7 2.3 2.3 2.4 2.6 2.8 2.6 2.6 2.7 2.4 2.5 2.3 2.7 2.1 2.8 2.4 2.1 2.5 2.8 2.4 2.4 2.5 2.7 2.5 2.3 2.6 2.4 2.6 2.4 2.6 2.6 2.5 2.4 oM . nI 2.5 2.7 ) DuPont-5386 Day 8 Day 9 Day 10 Day 11 8 2.8 2.8 2.8 2.8 9 2.9 2.9 2.9 2.9 0 3.0 3.0 3.0 3.0 2 3.2 3.2 3.2 3.2 5 3 .5 3.5 3.5 3.5 2 3.2 3.2 3.2 3.2 3 3.3 3.3 3.3 3.3 2 3.2 3.2 3.2 3.1 0 3.0 3.0 3.0 3.0 0 3.0 3.0 3.0 3.0 8 2.8 2.8 2.8 2.8 1 3.1 3.1 3.1 3.1 5 2.5 2.5 2.5 2.5 3 3.3 3.3 3.3 3.3 9 2.9 2.9 2.9 2.9 7 2.7 2.7 2.7 2.7 1 3.1 3.1 3.1 3.1 3 3.3 3.3 3.3 3.3 0 3.0 3.0 3.0 3.0 1 3.1 3.1 3.1 3.1 1 3.1 3.1 3.1 3.1 4 3.4 3.4 3.4 3.4 0 3.0 3.0 3.0 3.0 8 2.8 2.8 2.8 2.8 1 3 .1 3 .1 3.1 3.1 1 3.1 3.1 3.1 3.1 1 3.1 3 .1 3.1 3.1 0 3.0 3.0 3.0 3.0 x 3.1 3.1 3.1 3.1 3 3.3 3.3 3.3 3.3 3 3.3 3.3 3.3 3.3 0 3.0 3.0 3.0 3.0 3 3.3 3.3 3.3 3.3 0 3.0 3.0 3.0 3.0 3 3.3 3.3 3.3 3.3 Company Sanitized. Does not contain TSCA CBI ') I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3 .3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3.1 3 .0 3.1 3 .3 3.3 3.0 -)._-)> 3.0 3.3 2.8 2.9 3.0 3.2 3.5 3.2 3.3 3.2 3.0 3.0 2.8 3.1 2.5 3.3 2.9 2.7 3.1 3.3 3.0 3.1 3.1 3.4 3.0 2.8 3.1 3.1 3 .1 3.0 3.1 3.3 3.3 3.0 3.3 3.0 3.3 Day 14 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3 .5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3.6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 Day 15 3.1 3.5 3.6 3.7 4.1 3.7 3.7 3.7 3.5 3.4 3.3 3.6 2.9 3.8 3.2 3.2 3.7 3.7 3.5 3.7 3.7 4.0 3.6 3.1 3 .6 3.6 3.7 3.5 3.5 3.8 3.8 3.4 3.8 3.5 3.8 INDIVIDUAL DOSE VOLUMI Day 16 Day 17 Day 18 3.1 3.1 3.1 3.5 3.5 3.5 3.6 3.6 3.6 3.7 3.7 3.7 4.1 4.1 4.1 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.7 3.5 3.5 3.5 3.4 3.4 3.4 3.3 3.3 3.3 3.6 3.6 3.6 2.9 2.9 2.9 3.8 3.8 3.8 3.2 3.2 3.2 3.2 3.2 3.2 3.7 3.7 3.7 3.7 3.7 3.7 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 4.0 4.0 4.0 3.6 3.6 3.6 3.1 3.1 3.1 3.6 3.6 3.6 3.6 3.6 3.6 3.7 3.7 3.7 3.5 3.5 3.5 3.5 3.5 3.5 3.8 3.8 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.8 3.8 3.8 3.5 3.5 3.5 3.8 3.8 3.8 514 ) ES (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 3.1 3.1 3.5 3.5 3.5 3.5 3.5 3.9 3.9 3.9 3.6 3.6 3.9 3.9 3.9 3.7 3.7 4.3 4.3 4.3 4.1 4.1 4.5 4.5 4.5 3.7 3.7 4.2 4.2 4.2 3.7 3.7 4.1 4.1 4.1 3.7 3.7 4.1 4.1 4.1 3.5 3.5 3.9 3.9 3.9 3.4 3.4 3.7 3.7 3.7 3.3 3.3 3.7 3.7 3.7 3.6 3.6 3.9 3.9 3.9 2.9 2.9 3.3 3.3 3.3 3.8 3.8 4.1 4.1 4.1 3.2 3.2 3.7 3.7 3.7 3.2 3.2 3.6 3.6 3.6 3.7 3.7 4.2 4.2 4.2 3.7 3.7 4.2 4.2 4.2 3.5 3.5 3.8 3.8 3.8 3.7 3.7 4.2 4.2 4.2 3.7 3.7 4.2 4.2 4.2 4.0 4.0 4.5 4.5 4.5 3.6 3.6 3.9 3.9 3.9 3.1 3.1 3.5 3.5 3.5 3.6 3.6 4.0 4.0 4.0 3.6 3.6 4.0 4.0 4.0 3,7 3.7 4.2 4.2 4.2 3.5 3.5 3.9 3.9 3.9 3.5 3.5 4.0 4.0 4.0 3.8 3.8 4.1 4.1 4.1 3.8 3.8 4.3 4.3 4.3 3.4 3.4 3.9 3.9 3.9 3.8 3.8 4.3 4.3 4.3 3.5 3.5 3.9 3.9 3.9 3.8 3.8 4.2 4.2 4.2 ' am pany "O. contain TSCA c B1 )! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, V - 100 mg/kg/day 643250 3.5 3.5 643243 3.9 3.9 643311 3.9 3.9 643318 4.3 4.3 643247 4.5 4.5 643175 4.2 4.2 643314 4.1 4.1 643275 4.1 4.1 643257 3.9 3.9 643224 3.7 3.7 643169 3.7 3.7 643159 3.9 3.9 643286 3.3 3.3 643181 4.1 4.1 643206 3.7 3.7 643313 3.6 3.6 643182 4.2 4.2 643146 4.2 4.2 643312 3.8 3.8 643199 4.2 4.2 643267 4.2 4.2 643216 4.5 4.5 643244 3.9 3.9 643245 3.5 3.5 643301 4.0 4.0 643200 4.0 4.0 643255 4.2 4.2 643157 3.9 3.9 643238 4.0 4.0 643227 4.1 4.1 643164 4.3 4.3 643154 3.9 3.9 643156 4.3 4.3 643208 3.9 3.9 643190 4.2 4.2 Day 26 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 Day 27 3.5 3.9 3.9 4.3 4.5 4.2 4.1 4.1 3.9 3.7 3.7 3.9 3.3 4.1 3.7 3.6 4.2 4.2 3.8 4.2 4.2 4.5 3.9 3.5 4.0 4.0 4.2 3.9 4.0 4.1 4.3 3.9 4.3 3.9 4.2 INDIVIDUAL DOSE VOLUM: Day 28 Day 29 Day 30 3.9 3.9 3.9 4.2 4.2 4.2 4.2 4.2 4.2 4.6 4.6 4.6 4.8 4.8 4.8 4.5 4.5 4.5 4.3 4.3 4.3 4.5 4.5 4.5 4.1 4.1 4.1 4.0 4.0 4.0 4.0 4.0 4.0 4.3 4.3 4.3 3.6 3.6 3.6 4.4 4.4 4.4 3.8 3.8 3.8 3.9 3.9 3.9 4.6 4.6 4.6 4.5 4.5 4.5 4.0 4.0 4.0 4.7 4.7 4.7 4.5 4.5 4.5 4.9 4.9 4.9 4.3 4.3 4.3 3.8 3.8 3.8 4.4 4.4 4.4 4.4 4.4 4.4 4.6 4.6 4.6 4.2 4.2 4.2 4.1 4.1 4.1 4.5 4.5 4.5 4.7 4.7 4.7 4.2 4.2 4.2 4.7 4.7 4.7 4.1 4.1 4.1 4.5 4.5 4.5 515 ) ES (mL) Day 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 3.9 3.9 3.9 3.9 4.0 4.2 4.2 4.2 4.2 4.5 4.2 4.2 4.2 4.2 4.4 4.6 4.6 4.6 4.6 4.9 4.8 4.8 4.8 4.8 5.0 4.5 4.5 4.5 4.5 4.8 4.3 4.3 4.3 4.3 4.5 4.5 4.5 4.5 4.5 4.7 4.1 4.1 4.1 4.1 4.4 4.0 4.0 4.0 4.0 4.2 4.0 4.0 4.0 4.0 4.2 4.3 4.3 4.3 4.3 4.7 3.6 3.6 3.6 3.6 3.9 4.4 4.4 4.4 4.4 4.6 3.8 3.8 3.8 3.8 4.0 3.9 3.9 3.9 3.9 4.2 4.6 4.6 4.6 4.6 5.0 4.5 4.5 4.5 4.5 4.8 4.0 4.0 4.0 4.0 4.2 4.7 4.7 4.7 4.7 4.8 4.5 4.5 4.5 4.5 4.8 4.9 4.9 4.9 4.9 5.2 4.3 4.3 4.3 4.3 4.5 3.8 3.8 3.8 3.8 3.9 4.4 4.4 4.4 4.4 4.7 4.4 4.4 4.4 4.4 4.7 4.6 4.6 4.6 4.6 4.8 4.2 4.2 4.2 4.2 4.5 4.1 4.1 4.1 4.1 4.3 4.5 4.5 4.5 4.5 4.7 4.7 4.7 4.7 4.7 5.0 4.2 4.2 4.2 4.2 4.4 4.7 4.7 4.7 4.7 4.9 4.1 4.1 4.1 4.1 4.3 4.5 4.5 4.5 CO LO s COmpaV SanbK l- D<* "01 contain TSCA C8I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Male, V - 100 mg/kg/day 643250 4,0 5.9 643243 4.5 4.5 643311 4.4 4.4 643318 4.9 4.9 643247 5.0 5.0 643175 4.8 4.8 643314 4.5 4.5 643275 4.7 4.7 643257 4.4 4.4 643224 4.2 4.2 643169 4.2 4.2 643159 4.7 4.7 643286 3.9 3.9 643181 4.6 4.6 643206 4.0 4.0 643313 4.2 4.2 643182 5.0 5.0 643146 4.8 4.8 643312 4.2 4.2 643199 4.8 4.8 643267 4.8 4.8 643216 5.2 5.2 643244 4.5 4.5 643245 3.9 3.9 643301 4.7 4.7 643200 4.7 4.7 643255 4.8 4.8 643157 4.5 4.5 643238 4.3 4.3 643227 4.7 4.7 643164 5.0 5.0 643154 4.4 4.4 643156 4.9 4.9 643208 4.3 4.3 643190 4.8 4.8 Day 38 3.0 3.4 3.3 3.7 3.7 3.6 3.4 3.5 3.3 3.2 3.2 3.5 2.9 3.5 3.0 3.2 3.7 3.6 3.1 3.6 3.6 3.9 3.4 2.9 3.5 3.5 3.6 3.4 3.3 3.5 3.7 3.3 3.7 3.3 3.6 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 41 Day 42 3.0 3.0 3.0 3.1 3.4 3.4 3.4 3.5 3.3 3.3 3.3 3.5 3.7 3.7 3.7 3.8 3.7 3.7 3.7 3.9 3.6 3.6 3.6 3.8 3.4 3.4 3.4 3.6 3.5 3.5 3.5 3.7 3.3 3.3 3.3 3.4 3.2 3.2 3.2 3.3 3.2 3.2 3.2 3.3 3.5 3.5 3.5 3.6 2.9 2.9 2.9 3.1 3.5 3.5 3.5 3.7 3.0 3.0 3.0 3.1 3.2 3.2 3.2 3.3 3.7 3.7 3.7 3.9 3.6 3.6 3.6 3.7 3.1 3.1 3.1 3.2 3.6 3.6 3.6 3.7 3.6 3.6 3.6 3.8 3.9 3.9 3.9 4.1 3.4 3.4 3.4 3.5 2.9 2.9 2.9 3.0 3.5 3.5 3.5 3.6 3.5 3.5 3.5 3.7 3.6 3.6 3.6 3.8 3.4 3.4 3.4 3.6 3.3 3.3 3.3 3.5 3.5 3.5 3.5 3.8 3.7 3.7 3.7 3.9 3.3 3.3 3.3 3.4 3.7 3.7 3.7 3.9 3.3 3.3 3.3 3.4 3.6 3.6 3.6 3.8 Day 43 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3.4 3.8 DuPont-5386 Day 44 3 .1 3 .5 3. 5 3 .8 3 .9 3 .8 3 .6 3 .7 3 .4 3. 3 3. 3 3. 6 3 .1 3 .7 3 .1 3 .3 3 .9 3 .7 3 .2 3 .7 3 .8 4. 1 3 .5 3 .0 3 .6 3 .7 3 .8 3. 6 3 .5 3 .8 3 .9 3 .4 3 .9 3. 4 3 .8 Company Sanitized. Does not contain TSCACB1 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 45 Day 46 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3 .1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3.4 3.8 3.1 3.5 3.5 3.8 3.9 3.8 3.6 3.7 3.4 3.3 3.3 3.6 3.1 3.7 3.1 3.3 3.9 3.7 3.2 3.7 3.8 4.1 3.5 3.0 3.6 3.7 3.8 3.6 3.5 3.8 3.9 3.4 3.9 3.4 3.8 Day 47 INDIVIDUAL DOSE VOLUMES Day 48 Day 49 3.1 3.1 3.2 3.5 3.5 3.6 3.5 3.5 3.6 3.8 3.8 3.9 3.9 3.9 3.6 3.8 3.8 3.8 3.6 3.6 3.7 3.7 3.7 3.8 3.4 3.4 3.4 3.3 3.3 3.3 3.3 3.3 3.4 3.6 3.6 3.7 3.1 3.1 3.3 3.7 3.7 3.9 3.1 3.1 3.3 3.3 3.3 3.5 3.9 3.9 4.0 3.7 3.7 3.8 3.2 3.2 3.3 3.7 3.7 3.8 3.8 3.8 4.0 4.1 4.1 4.2 3.5 3.5 3.7 3.0 3.0 3.1 3.6 3.6 3.8 3.7 3.7 3.8 3 .8 3.8 4.0 3.6 3.6 3.8 3.5 3.5 3.7 3.8 3.8 4.0 3.9 3.9 4.1 3.4 3.4 3.6 3.9 3.9 4.1 3.4 3.4 3.6 3.8 3.8 3.9 517 (mL) 50 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4 .i 3.6 3.9 Day 51 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 Day 52 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 DuPont-5386 Day 53 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 COmPa"y Sani"'Z e i M conte,,, TSCA C B , ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, V - 100 mg /kg /day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3.8 4.0 4.2 3.7 3.1 3.8 3.8 4.0 3.8 3.7 4.0 4.1 3.6 4.1 3.6 3.9 3.2 3.6 3.6 3.9 3.6 3.8 3.7 3.8 3.4 3.3 3.4 3.7 3.3 3.9 3.3 3.5 4.0 3.8 3.3 3 .8 4.0 4.2 3.7 3.1 3 .8 3 .8 4.0 3 .8 3.7 4.0 4.1 3 .6 4.1 3.6 3.9 Day 56 INDIVIDUAL DOSE VOLUMES Day 57 Day 58 3.3 3.3 3.3 3.7 3.7 3.7 3.6 3.6 3.6 4.0 4.0 4.0 3.8 3.8 3.8 4.0 4.0 4.0 3.8 3.8 3.8 3.9 3.9 3.9 3.6 3.6 3.6 3.4 3.4 3.4 3.4 3.4 3.4 3.9 3.9 3.9 3.4 3.4 3.4 4.0 4.0 4.0 3.3 3.3 3.3 3.6 3.6 3.6 4.1 4.1 4.1 4.0 4.0 4.0 3.5 3.5 3.5 3.9 3.9 3.9 4.0 4.0 4.0 4.3 4.3 4.3 3.7 3.7 3.7 3.3 3.3 3.3 3.9 3.9 3.9 4.0 4.0 4.0 4.2 4.2 4.2 3.9 3.9 3.9 3.8 3 .8 3 .8 4.1 4.1 4.1 4.2 4.2 4.2 3.7 3.7 3.7 4.3 4.3 4.3 3.8 3.8 3.8 4.0 4.0 4.0 518 (mL) 59 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 Day 60 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3 .8 4.1 4.2 3.7 4.3 3.8 4.0 Day 61 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 ) DuPont-5386 Day 62 3.3 3.7 3.6 4.0 3.8 4.0 3.8 3.9 3.6 3.4 3.4 3.9 3.4 4.0 3.3 3.6 4.1 4.0 3.5 3.9 4.0 4.3 3.7 3.3 3.9 4.0 4.2 3.9 3.8 4.1 4.2 3.7 4.3 3.8 4.0 Company Sanitized. Does not contain TSCA CBt ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 64 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3 .8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3 .8 4.5 3.9 4.3 Day 65 INDIVIDUAL DOSE VOLUMES Day 66 Day 67 3.4 3.4 3.4 3.9 3.9 3.9 3.7 3.7 3.7 4.1 4.1 4.1 4.0 4.0 4.0 3.9 3.9 3.9 3.9 3.9 3.9 4.1 4.1 4.1 3.6 3.6 3.6 3.5 3.5 3.5 3.4 3.4 3.4 4.0 4.0 4.0 3.5 3.5 3.5 4.1 4.1 4.1 3.5 3.5 3.5 3.8 3.8 3.8 4.3 4.3 4.3 4.1 4.1 4.1 3.7 3.7 3.7 4.0 4.0 4.0 4.1 4.1 4.1 4.5 4.5 4.5 3.9 3.9 3.9 3.4 3.4 3.4 4.1 4.1 4.1 4.1 4.1 4.1 4.4 4.4 4.4 4.2 4.2 4.2 4.0 4.0 4.0 4.2 4.2 4.2 4.4 4.4 4.4 3.8 3.8 3.8 4.5 4.5 4.5 3.9 3.9 3.9 4.3 4.3 4.3 519 (mL) 68 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 69 3.4 3.9 3.7 4.1 4.0 3.9 3.9 4.1 3.6 3.5 3.4 4.0 3.5 4.1 3.5 3.8 4.3 4.1 3.7 4.0 4.1 4.5 3.9 3.4 4.1 4.1 4.4 4.2 4.0 4.2 4.4 3.8 4.5 3.9 4.3 Day 70 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 DuPont-5386 Day 71 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 Company Sanitized. Does not contain TS C A CBJ ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 72 Day 73 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.0 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.3 4.6 4.0 4.2 3.5 4.0 3.8 4.2 4.1 3.4 4.0 4.2 3.7 3.5 3.5 4.Q 3.6 4.3 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4.5 4.3 4.1 4.3 4.5 3.9 4.6 4.0 4.2 Day 74 INDIVIDUAL DOSE VOLUMES Day 75 Day 76 3.5 3.5 3.5 4.0 4.0 4.0 3.8 3.8 3.8 4.2 4.2 4.2 4.1 4.1 4.1 3.4 3.4 3.4 4.0 4.0 4.0 4.2 4.2 4.2 3.7 3.7 3.7 3.5 3.5 3.5 3.5 3.5 3.5 4.0 4.0 4.0 3.6 3.6 3.6 4.3 4.3 4.3 3.6 3.6 3.6 3.8 4.4 4.3 3.8 4.1 4.3 4.6 3.9 3.5 4.2 4.2 4. 5 4.3 4.1 4.3 4.5 3.9 4 .6 4.0 4.2 520 (mL) Day 77 Day 78 3.5 3.5 4.1 4.1 3.8 3.8 4.3 4.3 4.2 4.2 AK TEST DAY 77 4.0 4.0 4.2 4.2 3.8 3.8 3.6 3.6 3.6 3.6 4.1 4.1 3.7 3.7 4.4 4.4 3.5 3.5 Day 79 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 DuPont-5386 Day 80 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 Company Sanitized. Does not contain TSCA CBt )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ Day 81 Day 82 Male, V -- 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4b 3.5 3.5 4.1 3.8 4.3 4.2 4.0 4.2 3.8 3.6 3.6 4.1 3.7 4.4 3.5 Day 83 INDIVIDUAL DOSE VOLUMES Day 84 Day 85 3.5 3.6 3.6 4.1 4.1 4.1 3.8 3.9 3.9 4.3 4.3 4.3 4.2 4.2 4.2 4.0 3.6 3.6 4.2 4.1 4.1 3.8 3.8 3.8 3.6 3.7 3.7 3.6 3.6 3.6 4.1 4.0 4.0 3.7 3.8 3.8 4.4 4.5 4.5 3.5 3.7 3.7 521 (mL) 86 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 87 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Day 88 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 DuPont-5386 Day 89 3.6 4.1 3.9 4.3 4.2 3.6 4.1 3.8 3.7 3.6 4.0 3.8 4.5 3.7 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 90 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 3.7 4.2 3.9 4.4 4.3 4.0 4.1 3.9 3.7 INDIVIDUAL DOSE VOLUMES (mL) DuPont-5386 Company Sanitized. Does not contain TSCA CB! ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 0 Day 1 Male, VII - 250 mg/kg/day 643194 2.4 2.4 643252 2.2 2.2 643260 2.3 2.3 643315 2.4 2.4 643215 2.7 2.7 643193 2.7 2.7 643298 2.5 2.5 643201 2.7 2.7 643259 2.4 2.4 643174 2.8 2.8 643283 2.4 2.4 643149 2.6 2.6 643178 2.3 2.3 643152 2.9 2.9 643295 2.5 2.5 643289 2.1 2.1 643171 2.6 2.6 643158 2.6 2.6 643249 2.5 2.5 643161 2.6 2.6 643309 2.9 2.9 643248 2.6 2.6 643285 2.5 2.5 643278 2.4 2.4 643299 2.4 2.4 643274 2.4 2.4 643192 2.6 2.6 643222 2.6 2.6 643160 2.4 2.4 643191 2.7 2.7 643203 2.5 2.5 643282 2.8 2.8 643302 2.5 2.5 643317 2.5 2.5 643225 2.6 2.6 643296 2.7 2.7 643258 2.3 2.3 643316 2.4 2.4 643220 2.5 2.5 643236 2.5 2.5 643165 2.4 2.4 643266 2.5 2.5 643151 2.3 2.3 643234 2.8 2.8 643281 2.4 2.4 Day 2 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 Day 3 2.4 2.2 2.3 2.4 2.7 2.7 2.5 2.7 2.4 2.8 2.4 2.6 2.3 2.9 2.5 2.1 2.6 2.6 2.5 2.6 2.9 2.6 2.5 2.4 2.4 2.4 2.6 2.6 2.4 2.7 2.5 2.8 2.5 2.5 2.6 2.7 2.3 2.4 2.5 2.5 2.4 2.5 2.3 2.8 2.4 INDIVIDUAL DOSE VOLUMI Day 4 Day 5 Day 6 2.4 2.4 2.4 2.2 2.2 2.2 2.3 2.3 2.3 2.4 2.4 2.4 2.7 2.7 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2.7 2.7 2.7 2.4 2.4 2.4 2.8 2.8 2.8 2.4 2.4 2.4 2.6 2.6 2.6 2.3 2.3 2.3 2.9 2.9 2.9 2.5 2.5 2.5 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.6 2.6 2.6 2.9 2.9 2.9 2.6 2.6 2.6 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.7 2.7 2.7 2.5 2.5 2.5 2.8 2.8 2.8 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.7 2.7 2.7 2.3 2.3 2.3 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.5 2.5 2.5 2.3 2.3 2.3 2.8 2.8 2.8 2.4 2.4 2.4 523 ) ES (mL) Day 7 Day 8 Day 9 DuPont-5386 Day 10 Day 11 3.0 3.0 3.0 3.0 3.0 2.9 2.9 2.9 2.9 2.9 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 3.3 2.9 2.9 2.9 2.9 2.9 3.5 3.5 3.5 3.5 3.5 2.9 2.9 2.9 2.9 2.9 3.1 3.1 3.1 3.1 3.1 2.7 2.7 2.7 2.7 2.7 3.5 3.5 3.5 3.5 b 3.5 3.0 3.0 3.0 3.0 3.0 2.7 2.7 2.7 2.7 2.7 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.1 3.1 3.1 3.1 3.1 3.2 3.2 3.2 3.2 3.2 3.7 3.7 3.7 3.7 3.7 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 2.9 2.9 2.9 2.9 2.9 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.2 3.2 3.2 3.2 3 .2 3.2 3.2 3.2 3.2 3.2 3.0 3.0 3.0 3.0 3.0 3.4 3.4 3.4 3.4 3.4 3.2 3.2 3.2 3.2 3.2 3.5 3.5 3.5 3.5 3.5 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.3 3.3 3.3 3.3 3.3 3.4 3.4 3.4 3.4 3.4 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.1 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 2.8 2.8 2.8 2.8 2.8 3.4 3.4 3.4 3.4 3.4 3.0 3.0 3.0 3.0 3.0 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Male, VII - 250 mg/kg/day 643194 3.0 3.0 643252 2.9 2.9 643260 2.8 2.8 643315 2.9 2.9 643215 3.3 3.3 643193 3.4 3.4 643298 3.3 3.3 643201 3.3 3.3 643259 2.9 2.9 643174 3.5 3.5 643283 2.9 2.9 643149 3.1 3.1 643178 2.7 2.7 643152 3.5 3.5 643295 3.0 3.0 643289 2.7 2.7 643171 3.3 3.3 643158 3.4 3.4 643249 3.1 3.1 643161 3.2 3.2 643309 3.7 3.7 643248 3.1 3.1 643285 3.1 3.1 643278 2.9 2.9 643299 3.0 3.0 643274 3.0 3.0 643192 3.2 3.2 643222 3.2 3.2 643160 3.0 3.0 643191 3.4 3.4 643203 3.2 3.2 643282 3.5 3.5 643302 3.0 3.0 643317 3.0 3.0 643225 3.3 3.3 643296 3.4 3.4 643258 3.0 3.0 643316 3.0 3.0 643220 3.1 3.1 643236 3.1 3.1 643165 3.0 3.0 643266 3 .1 3.1 643151 2.8 2.8 643234 3.4 3.4 643281 3.0 3.0 Day 14 3.4 3.3 3.2 3 .3 3.7 3.8 3.8 3.8 3.4 3.9 3.4 3.6 3.1 4.1 3.4 3.1 3.9 3.9 3.6 3.6 4.2 3.5 3.5 3.4 3.5 3.5 3.7 3.7 3.3 3.8 3.7 4.1 3.5 3.5 3.7 3 .9 3.5 3.5 3.6 3.6 3 .5 3.7 3.3 3.8 3.4 Day 15 3.4 3.3 3.2 3.3 3.7 3.8 3.8 3.8 3.4 3.9 3.4 3.6 3.1 4.1 3.4 3.1 3.9 3.9 3.6 3.6 4.2 3.5 3.5 3.4 3.5 3.5 3.7 3.7 3.3 3.8 3.7 4.1 3.5 3.5 3.7 3.9 3.5 3.5 3.6 3.6 3.5 3.7 3.3 3.8 3.4 INDIVIDUAL DOSE VOLUMES Day 16 Day 17 Day 18 3.4 3.4 3.4 3.3 3.3 3.3 3.2 3.2 3.2 3.3 3.3 3.3 3.7 3.7 3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.9 3.9 3.9 3.4 3.4 3.4 3.6 3.6 3.6 3.1 3.1 3.1 4.1 4.1 4.1 3.4 3.4 3.4 3.1 3.1 3.1 3.9 3.9 3.9 3.9 3.9 3.9 3.6 3.6 3.6 3.6 3.6 3.6 4.2 4.2 4.2 3.5 3.5 3.5 3.5 3.5 3.5 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.7 3.7 3.7 3.3 3.3 3.3 3.8 3.8 3.8 3.7 3.7 3.7 4.1 4.1 4.1 3.5 3.5 3.5 3.5 3.5 3.5 3.7 3.7 3.7 3.9 3.9 3.9 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.6 3.6 3.5 3.5 3.5 3.7 3.7 3.7 3.3 3.3 3.3 3.8 3.8 3.8 3.4 3 .4 3.4 524 DuPont-5386 Day 21 Day 22 Day 23 4 3.8 3.8 3.8 3 3.7 3.7 3.7 2 3.5 3.5 3.5 3 3.7 3.7 3.7 7 4.2 4.2 4.2 8 4.3 4.3 4.3 8 4.2 4.2 4.2 8 4.3 4.3 4.3 4 3.9 3.9 3.9 9 4.5 4.5 4.5 4 3.7 3.7 3.7 6 4.0 4.0 4.0 1 3.4 3.4 3.4 1 4.6 4.6 4.6 4 3.8 3.8 3.8 1 3.5 3.5 3.5 9 4.5 4.5 4.5 9 4.4 4.4 4.4 6 3.9 3.9 3.9 6 4.2 4.2 4.2 2 4.7 4.7 4.7 5 3.9 3.9 3.9 5 3.9 3.9 3.9 4 3.8 3.8 3.8 5 3.9 3.9 3.9 5 3.9 3.9 3.9 7 4.2 4.2 4.2 7 4.1 4.1 4.1 3 3.8 3.8 3.8 8 4.2 4.2 4.2 7 4.2 4.2 4.2 1 4.7 4.7 4.7 5 3.9 3.9 3.9 5 3.9 3.9 3.9 7 4.1 4.1 4.1 9 4.4 4.4 4.4 5 4.0 4.0 4.0 5 4.0 4.0 4.0 6 4.0 4.0 4.0 6 4.1 4.1 4.1 5 4.0 4.0 4.0 7 4.1 4.1 4.1 3 3.6 3.6 3.6 8 4.3 4.3 4.3 4 3.9 3.9 3.9 Company Sanitized. Does not contain TSCA CB! ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Male, VII - 250 mg/kg/day 643194 3.8 3.8 643252 3.7 3.7 643260 3.5 3.5 643315 3.7 3.7 643215 4.2 4.2 643193 4.3 4.3 643298 4.2 4.2 643201 4.3 4.3 643259 3.9 3.9 643174 4.5 4.5 643283 3.7 3.7 643149 4.0 4.0 643178 3.4 3.4 643152 4.6 4.6 643295 3.8 3.8 643289 3.5 3.5 643171 4.5 4.5 643158 4.4 4.4 643249 3.9 3.9 643161 4.2 4.2 643309 4.7 4.7 643248 3.9 3.9 643285 3 .9 3.9 643278 3.8 3.8 643299 3.9 3.9 643274 3.9 3.9 643192 4.2 4.2 643222 4.1 4.1 643160 3.8 3.8 643191 4.2 4.2 643203 4.2 4.2 643282 4.7 4.7 643302 3.9 3.9 643317 3.9 3.9 643225 4.1 4.1 643296 4.4 4.4 643258 4.0 4.0 643316 4.0 4.0 643220 4.0 4.0 643236 4.1 4.1 643165 4.0 4.0 643266 4.1 4.1 643151 3.6 3.6 643234 4.3 4.3 643281 3.9 3.9 Day 26 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3.9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 Day 27 3.8 3.7 3.5 3.7 4.2 4.3 4.2 4.3 3 .9 4.5 3.7 4.0 3.4 4.6 3.8 3.5 4.5 4.4 3.9 4.2 4.7 3.9 3.9 3.8 3.9 3.9 4.2 4.1 3.8 4.2 4.2 4.7 3.9 3.9 4.1 4.4 4.0 4.0 4.0 4.1 4.0 4.1 3.6 4.3 3.9 INDIVIDUAL DOSE VOLUMI Day 28 Day 29 Day 30 4.1 4.1 4.1 4.0 4.0 4.0 3.8 3.8 3.8 4.0 4.0 4.0 4.5 4.5 4.5 4.6 4.6 4.6 4.5 4.5 4.5 4.6 4.6 4.6 4.3 4.3 4.3 4.9 4.9 4.9 4.0 4.0 4.0 4.4 4.4 4.4 2.9 2.9 2.9 5.0 5.0 5.0 4.1 4.1 4.1 3.8 3.8 3.8 4.8 4.8 4.8 4.6 4.6 4.6 4.2 4.2 4.2 4.5 4.5 4.5 5.0 5.0 5.0 4.2 4.2 4.2 4.2 4.2 4.2 4.1 4.1 4.1 4.2 4.2 4.2 4.2 4.2 4.2 4.6 4.6 4.6 4.4 4.4 4.4 4.0 4.0 4.0 4.4 4.4 4.4 4.5 4.5 4.5 5.1 5.1 5.1 4.2 4.2 4.2 4.2 4.2 4.2 4.3 4.3 4.3 4.7 4.7 4.7 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.3 4.5 4.5 4.5 4.3 4.3 4.3 4.5 4.5 4.5 4.0 4.0 4.0 4.6 4.6 4.6 4.2 4.2 4.2 525 iS (mL) Day 31 Day 32 Day 33 Day 34 DuPont-5386 Day 35 4.1 4.1 4.1 4.1 4.3 4.0 4.0 4.0 4.0 4.3 3.8 3.8 3.8 3.8 4.0 4.0 4.0 4.0 4.0 4.3 4.5 4.5 4.5 4.5 4.7 4.6 4.6 4.6 4.6 4.8 4.5 4.5 4.5 4.5 4.8 4.6 4.6 4.6 4.6 4.9 4.3 4.3 4.3 4.3 4.5 4.9 4.9 4.9 4.9 5.2 4.0 4.0 4.0 4.0 4.2 4.4 4.4 4.4 4.4 4.7 2.9 2.9 2.9 2.9 3.2 5.0 5.0 5.0 5.0 5.3 4.1 4.1 4.1 4.1 4.3 3.8 3.8 3.8 3.8 4.0 4.8 4.8 4.8 4.8 5.1 4.6 4.6 4.6 4.6 4.9 4.2 4.2 4.2 4.2 4.6 4.5 4.5 4.5 4.5 4.9 5.0 5.0 5.0 5.0 5.3 4.2 4.2 4.2 4.2 4.4 4.2 4.2 4.2 4.2 4.4 4.1 4.1 4.1 4.1 4.3 4.2 4.2 4.2 4.2 4.4 4.2 4.2 4.2 4.2 4.5 4.6 4.6 4.6 4.6 4.9 4.4 4.4 4.4 4.4 4.7 4.0 4.0 4.0 4.0 4.2 4.4 4.4 4.4 4.4 4.6 4.5 4.5 4.5 4.5 4.8 5.1 5.1 5.1 5.1 5.4 4.2 4.2 4.2 4.2 4.5 4.2 4.2 4.2 4.2 4.5 4.3 4.3 4.3 4.3 4.5 4.7 4.7 4.7 4.7 5.0 4.3 4.3 4.3 4.3 4.6 4.3 4.3 4.3 4.3 4.6 4.3 4.3 4.3 4.3 4.5 4 . 5 4.5 4.5 4.5 4.5 4.3 4.3 4.3 4.3 4.6 4.5 4.5 4.5 4.5 4.8 4.0 4.0 4.0 4.0 4.2 4.6 4.6 4.6 4.6 4.9 4.2 4.2 4.2 4.2 4.5 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 36 Day 37 Male, VII - 250 mg/kg/day 643194 4.3 4.3 643252 4.3 4.3 643260 4.0 4.0 643315 4.3 4.3 643215 4.7 4.7 643193 4.8 4.8 643298 4.8 4.8 643201 4.9 4.9 643259 4.5 4.5 643174 5.2 5.2 643283 4.2 4.2 643149 4.7 4.7 643178 3.2 3.2 643152 5.3 5.3 643295 4.3 4.3 643289 4.0 4.0 643171 5.1 5.1 643158 4.9 4.9 643249 4.6 4.6 643161 4.9 4.9 643309 5.3 5.3 643248 4.4 4.4 643285 4.4 4.4 643278 4.3 4.3 643299 4.4 4.4 643274 4.5 4.5 643192 4.9 4.9 643222 4.7 4.7 643160 4.2 4.2 643191 4.6 4.6 643203 4.8 4.8 643282 5.4 5.4 643302 4.5 4.5 643317 4.5 4.5 643225 4.5 4.5 643296 5.0 5.0 643258 4.6 4.6 643316 4.6 4.6 643220 4.5 4.5 643236 4.5 4.5 643165 4.6 4.6 643266 4.8 4.8 643151 4.2 4.2 643234 4.9 4.9 643281 4.5 4.5 Day 38 3.2 3.3 3.0 3.2 3.5 3.6 3.6 3.7 3.4 3.9 3.1 3.5 2.4 4.0 3.2 3.0 3.8 3.7 3.5 3.6 4.0 3.3 3.3 3.2 3.3 3.4 3.7 3.5 3.2 3.5 3.6 4.0 3.3 3.3 3.4 3.7 3.4 3.4 3.4 3.4 3.5 3.6 3.1 3.7 3.4 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 41 Day 42 3.2 3.2 3.2 3.4 3.3 3.3 3.3 3.4 3.0 3.0 3.0 3.1 3.2 3.2 3.2 3.4 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.8 3.6 3.6 3.6 3.7 3.7 3.7 3.7 3.9 3.4 3.4 3.4 3.6 3.9 3.9 3.9 4.0 3.1 3.1 3.1 3.2 3.5 3.5 3.5 3.7 2.4 2.4 2.4 2.7 4.0 4.0 4.0 4.1 3.2 3.2 3.2 3.4 3.0 3.0 3.0 3.2 3.8 3.8 3.8 4.0 3.7 3.7 3.7 3.8 3.5 3.5 3.5 3.7 3.6 3.6 3.6 3.7 4.0 4.0 4.0 4.1 3.3 3.3 3.3 3.5 3.3 3.3 3.3 3.4 3.2 3.2 3.2 3.4 3.3 3.3 3.3 3.5 3.4 3.4 3.4 3.5 3.7 3.7 3.7 3.9 3.5 3.5 3.5 3.7 3.2 3.2 3.2 3.3 3.5 3 .5 3.5 3.6 3.6 3.6 3.6 3.7 4.0 4.0 4.0 4.2 3.3 3.3 3.3 3.5 3.3 3.3 3 .3 3.5 3.4 3.4 3.4 3.6 3.7 3.7 3.7 3.8 3.4 3.4 3.4 b 2.9 3.4 3.4 3.4 3.5 3.4 3.4 3.4 3.5 3.4 3.4 3.4 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.6 3.8 3.1 3.1 3.1 3.2 3.7 3.7 3.7 3.8 3.4 3.4 3.4 3.4 Day 43 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 ) DuPont-5386 Day 44 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 Company Sanitized. Does not contain 526 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 45 Day 46 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3.2 3.8 3.4 3.4 3.4 3.1 3.4 3.6 3.8 3.7 3.9 3.6 4.0 3.2 3.7 2.7 4.1 3.4 3.2 4.0 3.8 3.7 3.7 4.1 3.5 3.4 3.4 3.5 3.5 3.9 3.7 3.3 3.6 3.7 4.2 3.5 3.5 3.6 3.8 2.9 3.5 3.5 3.5 3.6 3.8 3 .2 3.8 3.4 Day 47 INDIVIDUAL DOSE VOLUMES Day 48 Day 49 3.4 3.4 3.5 3.4 3.4 3.3 3.1 3.1 3.1 3.4 3.4 3.4 3.6 3.6 3.6 3.8 3.8 3.8 3.7 3.7 3.7 3.9 3.9 3.8 3.6 3.6 3.5 4.0 4.0 4.0 3.2 3.2 3.2 3.7 3.7 3.8 2.7 2.7 2.7 4.1 4.1 4.3 3.4 3.4 3.4 3.2 3.2 3.2 4.0 4.0 4.1 3.8 3.8 4.0 3.7 3.7 3.7 3.7 3.7 3.8 4.1 4.1 4.2 3.5 3.5 3.4 3.4 3.4 3.5 3.4 3.4 3.4 3.5 3.5 3.6 3.5 3.5 3.6 3.9 3.9 3.9 3.7 3.7 3.7 3.3 3.3 3.4 3.6 3 .6 3.7 3.7 3.7 3.8 4.2 4.2 4.4 3.5 3.5 3.6 3.5 3.5 3.5 3.6 3.6 3.6 3.8 3.8 3.9 2.9 2.9 3.3 3.5 3.5 3.6 3 .5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.4 3.8 3.8 3.9 3.2 3.2 3.3 3.8 3.8 3.9 3.4 3.4 3.6 527 (mL) ay 50 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 Day 51 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 Day 52 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 DuPont-5386 Day 53 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 mpany ^an,"t,zef. Does not contain TSCA C M ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 54 Day 55 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.5 3.3 3.1 3.4 3.6 3.8 3.7 3.8 3.5 4.0 3.2 3.8 2.7 4.3 3.4 3.2 4.1 4.0 3.7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3.3 3.6 3.5 3.6 3.4 3.9 3.3 3.9 3.6 3.5 3.3 3.1 3.4 3 .6 3.8 3.7 3.8 3.5 4.0 3.2 3 .8 2.7 4.3 3.4 3.2 4.1 4.0 3 .7 3.8 4.2 3.4 3.5 3.4 3.6 3.6 3.9 3.7 3.4 3.7 3.8 4.4 3.6 3.5 3.6 3.9 3 .3 3 .6 3.5 3.6 3.4 3.9 3.3 3 .9 3.6 Day 56 INDIVIDUAL DOSE VOLUMES Day 57 Day 58 3.6 3.6 3.6 3.4 3.4 3.4 3.2 3.2 3.2 3.4 3.4 3.4 3.7 3.7 3.7 3.1 3.1 b 3.1 3.9 3.9 3.9 3.8 3.8 3.8 3.5 3.5 3.5 4.1 4.1 4.1 3.2 3.2 3.2 3.9 3.9 3.9 2.8 2.8 2.8 4.3 4.3 4.3 2.9 2.9 2.9 2.9 2.9 2.9 4.1 4.1 4.1 4.1 4.1 4.1 3.8 3.8 3.8 3.9 3.9 3.9 3.7 3.7 3.7 3.5 3.5 3.5 3.5 3.5 3.5 3.6 3.6 3.6 3.7 3.7 3.7 3.7 3.7 3.7 4.0 4.0 4.0 3.8 3.8 3.8 3.5 3.5 3.5 3.7 3.7 3.7 3.8 3 .8 3.8 4.4 4.4 4.4 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 3.6 4.0 4.0 4.0 3.4 3.4 3.4 3.7 3.7 3.7 3.5 3.5 3.5 3.8 3.8 3.8 3.4 3.4 3.4 3.9 3.9 3.9 3.4 3.4 3.4 3.9 3.9 3.9 3.7 a 3.7 528 (niL) 59 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 Day 60 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.3 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3 .8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 Day 61 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 DuPont-5386 Day 62 3.6 3.4 3.2 3.4 3.7 3.1 3.9 3.8 3.5 4.1 3.2 3.9 2.8 4.3 2.9 2.9 4.1 4.1 3.8 3.9 3.7 3.5 3.5 3.6 3.7 3.7 4.0 3.8 3.5 3.7 3.8 4.4 3.6 3.6 3.6 4.0 3.4 3.7 3.5 3.8 3.4 3.9 3.4 3.9 3.7 Company Sanitized. Does not contain TSCA CBI I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 64 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 Day 65 INDIVIDUAL DOSE VOLUMES Day 66 Day 67 3.7 3.7 3.7 3.6 3.6 3.6 3.3 3.3 3.3 3.6 3.6 3.6 3.7 3.7 3.7 3.5 3.5 3.5 4.0 4.0 4.0 4.0 4.0 4.0 3.5 3.5 3.5 4.3 4.3 4.3 3.2 3.2 3.2 3.9 3.9 3.9 2.8 2.8 2.8 4.4 4.4 4.4 2.9 2.9 2.9 3.0 3.0 3.0 4.1 4.1 4.1 4.2 4.2 4.2 3.9 3.9 3.9 3.6 3.6 3.6 4.0 4.0 4.0 3.2 3.2 3.2 3.4 3.4 3.4 3.3 3.3 3.3 3.7 3.7 3.7 3.8 3.8 3.8 3.8 3.8 3.8 3.7 3.7 3.7 3.6 3.6 3.6 3.8 3.8 3.8 3.9 3.9 3.9 4.3 4.3 4.3 3.4 3.4 3.4 3.6 3.6 3.6 3.7 3.7 3.7 4.0 4.0 4.0 3.6 3.6 3.6 3.8 3.8 3.8 3.3 3.3 3.3 3.6 3.6 3.6 3.3 3.3 3.3 4.0 4.0 4.0 3.2 3.2 3.2 3.7 3.7 3.7 3.8 3.8 3.8 529 I (mL) 68 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3 .8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3 .3 3.6 3.3 4.0 3.2 3.7 3.8 Day 69 3.7 3.6 3.3 3.6 3.7 3.5 4.0 4.0 3.5 4.3 3.2 3.9 2.8 4.4 2.9 3.0 4.1 4.2 3.9 3.6 4.0 3.2 3.4 3.3 3.7 3.8 3.8 3.7 3.6 3.8 3.9 4.3 3.4 3.6 3.7 4.0 3.6 3.8 3.3 3.6 3.3 4.0 3.2 3.7 3.8 DuPont-5386 Day 70 Day 71 3.8 3.8 2.8 2.8 3.3 3.3 3.7 3.7 3.2 3.2 3.6 3.6 4.0 4.0 4.0 4.0 3.7 3.7 4.3 4.3 3.0 3.0 3.9 3.9 2.8 2.8 4.5 4.5 2.5 2.5 3.2 3.2 3.4 3.4 4.3 4.3 3.4 3.4 3.6 3.6 3.7 AK TEST DAY 3.0 3.0 3.3 3.3 3.6 3.6 3.6 3.6 3.8 3.8 3.9 3.9 3.9 3.9 3.6 3.6 3.8 3.8 4.0 4.0 3.7 3.7 2.8 2.8 2.9 2.9 3.8 3.8 3.2 3.2 3.6 3.6 3.8 3.8 3.3 3.3 3.8 3.8 3.5 3.5 4.0 4.0 3.2 3.2 3.3 3.3 3.8 3.8 Company Sanitized. Does not contain T S C A C B l ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 72 Day 73 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3.0 3.9 2. 8 4.5 2. 5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3.8 3.9 3.9 3.6 3.8 4. 0 3 .7 2.8 2.9 3.8 3.2 3.6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 3.8 2.8 3.3 3.7 3.2 3.6 4.0 4.0 3.7 4.3 3. 0 3.9 2.8 4.5 2.5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3 .8 3 .9 3. 9 3. 6 3.8 4.0 3.7 2. 8 2.9 3 .8 3.2 3. 6 3.8 3.3 3.8 3.5 4.0 3.2 3.3 3.8 Day 74 INDIVIDUAL DOSE VOLUMES Day 75 Day 76 3.8 3.8 3.8 2.8 2.8 2 . 8 3.3 3.3 3.3 3.7 3.7 3.7 3.2 3.2 3.2 3.6 3.6 3 . 6 4.0 4 . 0 4.0 4.0 4.0 4.0 3.7 3.7 3.7 4.3 4.3 4.3 3.0 3.0 3.0 3.9 3.9 3.9 2.8 2 . 8 2 . 8 4.5 4.5 4.5 2.5 2.5 2 . 5 3.2 3.4 4.3 3.4 3.6 3.0 3.3 3.6 3.6 3.8 3.9 3.9 3.6 3.8 4.0 3.7 2. 8 2.9 3.8 3 . 8 3.8 3 . 2 3.2 3.2 3.6 3 . 6 3.6 3.8 3.8 3.8 3.3 3 . 3 3.3 3.8 3.8 3.8 3.5 3.5 3.5 4 . 0 4.0 4.0 3.2 3.2 3.2 3.3 3.3 3.3 3.8 530 (iiL) 77 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 Day 78 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 Day 79 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 DuPont-5386 Day 80 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.8 3.8 3.8 3.9 3.9 3.9 3.9 3.1 3.1 3.1 3.1 3.8 3.8 3.8 3.8 3.4 3.4 3.4 3.4 3.6 3.6 3.6 3.6 2.9 2.9 2.9 2.9 3.9 3.9 3.9 3.9 3.0 3.0 3.0 3.0 3.8 3.8 3.8 3.8 Company SanRfead. Does not coni,ft, tsca CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 81 Day 82 Male, VII - 250 m g /kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 3.8 3.4 3.4 3.5 3 .7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3.9 3.0 3.8 3.8 3.4 3.4 3.5 3.7 3.8 3.7 4.1 3.4 4.4 3.3 4.0 2.6 4.5 3.2 3.8 3.9 3.1 3.8 3.4 3.6 2.9 3 .9 3.0 3.8 Day 83 INDIVIDUAL DOSE VOLUMES Day 84 Day 85 3.8 3.9 3.9 3.4 3.8 3.8 3.4 3.4 3.4 3.5 3.7 3.7 3.7 3.9 3.9 3.8 4.0 4.0 3.7 4.0 4.0 4.1 4.2 4.2 3.4 3.7 3.7 4.4 4.4 4.4 3.3 3.3 3.3 4.0 4.1 4.1 2.6 2.9 2.9 4.5 4.7 4.7 3.2 3.2 3.2 3 .8 4.0 4.0 3.9 4.2 4.2 3.1 3.6 3.6 3.8 3.9 3.9 3.4 3.5 3.5 3.6 3.9 3.9 2.9 3.6 3.6 3.9 4.1 4.1 3.0 3.4 3.4 3.8 3.8 3.8 531 (mL) 86 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 Day 87 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 Day 88 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 ) DuPont-5386 Day 89 3.9 3.8 3.4 3.7 3.9 4.0 4.0 4.2 3.7 4.4 3.3 4.1 2.9 4.7 3.2 4.0 4.0 4.0 4.0 4.2 4.2 4.2 4.2 3.6 3.6 3.6 3.6 3.9 3.9 3.9 3.9 3.5 3.5 3.5 3.5 3.9 3.9 3.9 3.9 3.6 3.6 3.6 3.6 4.1 4.1 4.1 4.1 3.4 3.4 3.4 3.4 3.8 3.8 3.8 Company Sanitized. Does not contain TSCA CBt J CO H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 90 Male, Vii - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 J \J 4 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 4.0 4.0 3.5 3.8 4.0 4.2 4.1 4.3 3.8 4.5 INDIVIDUAL DOSE VOLUMES (mL) 532 DuPont-5386 Company sa,,ftfe e i contain TSCAcBf ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 0 Day 1 Female, II - 0 mg/kg/day 643477 1.7 1.7 643374 1.8 1.8 643406 1.6 1.6 643486 1.8 1.8 643361 1.9 1.9 643463 2.2 2.2 643398 1.7 1.7 643436 1.8 1.8 643362 1.8 1.8 643354 1.6 1.6 643402 1.8 1.8 643383 1.7 1.7 643465 2.1 2.1 643484 1.8 1.8 643384 1.9 1.9 643352 1.9 1.9 643343 1.7 1.7 643459 2.1 2.1 643394 1.9 1.9 643480 2.0 2.0 643319 2.0 2.0 643350 1.9 1.9 643363 2.0 2.0 643397 1.9 1.9 643421 1.8 1.8 643420 2.1 2.1 643419 2 .1 2.1 643414 2.1 2.1 643401 1.8 1.8 643455 1.9 1.9 643378 2.2 2.2 643393 1.9 1.9 643447 1.9 1.9 643478 1.8 1.8 643386 1.8 1.8 643405 2.1 2.1 643425 2.0 2.0 643448 2.1 2.1 643426 1.8 1.8 643415 2.1 2.1 643453 2.0 2.0 643330 1.7 1.7 643336 2.0 2.0 643387 1.9 1.9 643377 2.0 2.0 Day 2 1.7 1.8 1.6 1.8 1.9 2.2 1.7 1.8 1.8 1.6 1.8 1.7 2.1 1.8 1.9 1.9 1.7 2.1 1.9 2.0 2.0 1.9 2.0 1.9 1.8 2.1 2.1 2.1 1.8 1.9 2.2 1. 9 1.9 1.8 1.8 2.1 2.0 2.1 1.8 2.1 2.0 1.7 2.0 1.9 2.0 Day 3 1.7 1.8 1.6 1.8 1.9 2.2 1.7 1.8 1.8 1.6 1.8 1.7 2.1 1.8 1.9 1.9 1.7 2.1 1.9 2.0 2.0 1.9 2.0 1.9 1.8 2.1 2.1 2.1 1.8 1.9 2.2 1.9 1.9 1.8 1.8 2.1 2.0 2.1 1.8 2.1 2.0 1.7 2.0 1.9 2.0 INDIVIDUAL DOSE VOLUMES Day 4 Day 5 Day 6 1.7 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.6 1.8 1.8 1.8 1.9 1.9 1.9 2.2 2.2 2.2 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.7 2.1 2.1 2.1 1.8 1.8 1.8 1.9 1.9 1.9 1.9 1.9 1.9 1.7 1.7 1.7 2.1 2.1 2.1 1.9 1.9 1.9 2.0 2.0 2.0 2.0 2.0 2.0 1.9 1.9 1.9 2.0 2.0 2.0 1.9 1.9 1.9 1.8 1.8 1.8 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 2.1 1.8 1.8 1.8 1.9 1.9 1.9 2.2 2.2 2.2 1.9 1.9 1.9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 1.8 1.8 2.1 2.1 2.1 2.0 2.0 2.0 2.1 2.1 2.1 1.8 1.8 1.8 2.1 2.1 2.1 2.0 2.0 2.0 1.7 1.7 1.7 2.0 2.0 2.0 1.9 1.9 1.9 2.0 2.0 2.0 533 ) DuPont-5386 Day 8 Day 9 Day 10 Day 11 0 2.0 2.0 2.0 2.0 1 2.1 2.1 2.1 2.1 9 1.9 1.9 1.9 1.9 9 1.9 1.9 1.9 1.9 1 2.1 2.1 2.1 2.1 4 2.4 2.4 2.4 2.4 9 1.9 1.9 1.9 1.9 0 2.0 2.0 2.0 2.0 1 2.1 2.1 2.1 2.1 7 1.7 1.7 1.7 1.7 9 1.9 1.9 1.9 1.9 9 1.9 1.9 1.9 1.9 2 2.2 2.2 2.2 2.2 9 1.9 1.9 1.9 1.9 2 2.2 2.2 2.2 2.2 1 2.1 2.1 2.1 2.1 9 1.9 1.9 1.9 1.9 3 2.3 2.3 2.3 2.3 3 2.3 2.3 2.3 2.3 3 2.3 2.3 2.3 2.3 3 2.3 2.3 2.3 2.3 1 2.1 2.1 2.1 2.1 3 2.3 2.3 2.3 2.3 3 2.3 2.3 2.3 2.3 0 2.0 2.0 2.0 2.0 3 2.3 2.3 2.3 2.3 4 2.4 2.4 2.4 2.4 5 2.5 2.5 2.5 2.5 8 1.8 1.8 1.8 1.8 1 2.1 2.1 2.1 2.1 4 2.4 2.4 2.4 2.4 3 2.3 2.3 2.3 2.3 -1 2.2 2.2 2.2 2.2 0 2.0 2.0 2.0 2.0 2 2.2 2.2 2.2 2.2 4 2.4 2.4 2.4 2.4 3 2.3 2.3 2.3 2.3 3 2.3 2.3 2.3 2.3 1 2.1 2.1 2.1 2.1 4 2.4 2.4 2.4 2.4 2 2.2 2.2 2.2 2.2 9 1.9 1.9 1.9 1.9 2 2.2 2.2 2.2 2.2 1 2.1 2.1 2.1 2.1 2 2.2 2.2 2.2 2.2 Company SamHzed. Does no, eonla,n T s n i CB) ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 12 Day 13 Female, II - 0 mg/kg/day 643477 2.0 2.0 643374 2.1 2.1 643406 1.9 1.9 643486 1.9 1.9 643361 2.1 2.1 643463 2.4 2.4 643398 1.9 1.9 643436 2.0 2.0 643362 2.1 2.1 643354 1.7 1.7 643402 1.9 1.9 643383 1.9 1.9 643465 2.2 2.2 643484 1.9 1.9 643384 2.2 2.2 643352 2.1 2.1 643343 1.9 1.9 643459 2.3 2.3 643394 2.3 2.3 643480 2.3 2.3 643319 2.3 2.3 643350 2.1 2.1 643363 2.3 2.3 643397 2.3 2.3 643421 2.0 2.0 643420 2.3 2.3 643419 2.4 2.4 643414 2.5 2.5 643401 1.8 1.8 643455 2.1 2.1 643378 2.4 2.4 643393 2.3 2.3 643447 2.2 2.2 643478 2.0 2.0 643386 2.2 2.2 643405 2.4 2.4 643425 2.3 2.3 643448 2.3 2.3 643426 2.1 2.1 643415 2.4 2.4 643453 2.2 2.2 643330 1.9 1.9 643336 2.2 2.2 643387 2.1 2.1 643377 2.2 2.2 Day 14 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2.3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2.2 2.7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 Day 15 2.1 2.3 2.1 1.9 2.2 2.7 2.1 2.3 2.4 1.9 2.2 2.0 2.4 2.1 2.4 2.3 2.1 2.5 2.4 2.4 2.4 2.2 2.6 2.5 2.2 2.5 2.6 2.6 2.0 2.2 2.7 2.4 2.4 2.1 2.2 2.7 2.4 2.3 2.3 2.6 2.5 2.1 2.5 2.4 2.4 INDIVIDUAL DOSE VOLUMES Day 16 Day 17 Day 18 2.1 2.1 2.1 2.3 2.3 2.3 2.1 2.1 2.1 1.9 1.9 1.9 2.2 2.2 2.2 2.7 2.7 2.7 2.1 2.1 2.1 2.3 2.3 2.3 2.4 2.4 2.4 1.9 1.9 1.9 2.2 2.2 2.2 2.0 2.0 2.0 2.4 2.4 2.4 2.1 2.1 2.1 2.4 2.4 2.4 2.3 2.3 2.3 2.1 2.1 2.1 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.6 2.6 2.6 2.5 2.5 2.5 2.2 2.2 2.2 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 2.0 2.0 2.0 2.2 2.2 2.2 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.2 2.2 2.2 2.7 2.7 2.7 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.5 2.5 2.5 2.1 2.1 2.1 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.4 534 ) DuPont-5386 1 Day 20 Day 21 Day 22 Day 23 1 2.1 2.4 2.4 2.4 3 2.3 2.4 2.4 2.4 1 2.1 2 . 2 2.2 2.2 9 1.9 2.1 2.1 2.1 2 2.2 2.6 2.6 2.6 7 2.7 2.7 2.7 2.7 1 2.1 2.3 2.3 2.3 3 2.3 2.4 2.4 2.4 4 2.4 2.5 2.5 2.5 9 1.9 2.1 2.1 2.1 2 2.2 2.3 2.3 2.3 0 2.0 2.2 2.2 2.2 4 2.4 2.7 2.7 2.7 1 2.1 2 . 2 2.2 2.2 4 2.4 2.5 2.5 2.5 3 2.3 2.5 2.5 2.5 1 2.1 2.3 2.3 2.3 5 2.5 2.6 2.6 2.6 4 2.4 2.5 2.5 2.5 4 2.4 2.5 2.5 2.5 4 2.4 2.7 2.7 2.7 2 2.2 2.3 2.3 2.3 6 2.6 2 . 6 2.6 2.6 5 2.5 2.6 2.6 2.6 2 2.2 2.3 2.3 2.3 5 2.5 2.8 2.8 2.8 6 2.6 2.9 2.9 2.9 6 2.6 2.8 2.8 2.8 0 2.0 2.1 2.1 2.1 2 2.2 2.4 2.4 2.4 7 2.7 2.9 2.9 2.9 4 2.4 2.6 2.6 2.6 4 2.4 2.6 2.6 2.6 1 2.1 2.3 2.3 2.3 2 2.2 2.4 2.4 2.4 7 2.7 2.8 2.8 2.8 4 2.4 2.7 2.7 2.7 3 2.3 2.5 2.5 2.5 3 2.3 2.6 2.6 2.6 6 2.6 2.7 2.7 2.7 5 2.5 2.7 2.7 2.7 1 2.1 2.2 2.2 2.2 5 2.5 2.7 2.7 2.7 4 2.4 2.5 2.5 2.5 4 2.4 2 . 6 2.6 2.6 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Female, II - 0 mg /kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2.9 2.8 2 .1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2.9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 Day 26 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2.9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 ay 27 2.4 2.4 2.2 2.1 2.6 2.7 2.3 2.4 2.5 2.1 2.3 2.2 2.7 2.2 2.5 2.5 2.3 2.6 2.5 2.5 2.7 2.3 2.6 2.6 2.3 2.8 2.9 2.8 2.1 2.4 2.9 2.6 2.6 2.3 2.4 2.8 2.7 2.5 2.6 2.7 2.7 2.2 2.7 2.5 2.6 INDIVIDUAL DOSE VOLUMES ay 28 Day 29 ay 30 2.4 2.4 2.4 2.5 2.5 2.5 2.3 2.3 2.3 2.1 2.1 2.1 2.7 2.7 2.7 2.9 2.9 2.9 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.6 2.6 2.2 2.2 2.2 2.4 2.4 2.4 2.2 2.2 2.2 2.8 2.8 2.8 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.6 2.4 2.4 2.4 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.9 2.9 2.9 2.7 2.7 2.7 2.4 2.4 2.4 2.9 2.9 2.9 3.1 3.1 3 .1 2.9 2.9 2.9 2.3 2.3 2.3 2.6 2.6 2.6 3.0 3.0 3.0 2.9 2.9 2.9 2.7 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.5 3.0 3.0 3.0 2.8 2.8 2.8 2.7 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 2.8 2.8 2.8 2.4 2.4 2.4 2.9 2.9 2.9 2.7 2.7 2.7 2.7 2.7 2.7 535 ) DuPont-5386 Day 33 Day 34 Day 35 4 2.4 2.4 2.6 5 2.5 2.5 2.6 3 2.3 2.3 2.4 1 2.1 2.1 2.2 7 2.7 2.7 2.8 9 2.9 2.9 3.1 4 2.4 2.4 2.6 6 2.6 2.6 2.7 6 2.6 2.6 2.8 2 2.2 2.2 2.3 4 2.4 2.4 2.5 2 2.2 2.2 2.4 8 2.8 2.8 2.7 3 2.3 2.3 2.4 6 2.6 2.6 2.8 6 2.6 2.6 2.8 4 2.4 2.4 2.6 7 2.7 2.7 2.9 7 2.7 2.7 2.8 7 2.7 2.7 2.9 7 2.7 2.7 2.9 4 2.4 2.4 2.5 9 2.9 2.9 3.0 7 2.7 2.7 2.8 4 2.4 2.4 2.5 9 2.9 2.9 3.2 1 3.1 3.1 3.2 9 2.9 2.9 3.1 3 2.3 2.3 2.3 6 2.6 2.6 2.6 0 3.0 3.0 3.2 9 2.9 2.9 3.0 7 2.7 2.7 2.9 4 2.4 2.4 2.4 5 2.5 2.5 2.5 0 3.0 3.0 3.2 8 2.8 2.8 2.9 7 2.7 2.7 2.8 7 2.7 2.7 2.9 0 3.0 3.0 3.0 8 2.8 2.8 2.9 4 2.4 2.4 2.5 9 2.9 2.9 3.0 7 2.7 2.7 2.9 7 2.7 2.7 2.9 Company Sanitized. Does ,, o ,c 0,,ta,n TSCACBI )> H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Female, II - Q mg/kg/day 643477 2.6 2.6 643374 2 . 6 2.6 643406 2.4 2.4 643486 2.2 2.2 643361 2.8 2.8 643463 3.1 3.1 643398 2.6 2.6 643436 2.7 2.7 643362 2.8 2.8 643354 2.3 2.3 643402 2.5 2.5 643383 2.4 2.4 643465 2 . 7 2.7 643484 2.4 2.4 643384 2.8 2.8 643352 2.8 2.8 643343 2.6 2.6 643459 2.9 2 . 9 643394 2.8 2.8 643480 2.9 2.9 643319 2.9 2.9 643350 2 . 5 2 . 5 643363 3 . 0 3.0 643397 2.8 2 . 8 643421 2 . 5 2.5 643420 3.2 3.2 643419 3.2 3.2 643414 3 . 1 3 . 1 643401 2.3 2.3 643455 2.6 2.6 643378 3.2 3 . 2 643393 3.0 3.0 643447 2 . 9 2 . 9 643478 2.4 2.4 643386 2 . 5 2.5 643405 3.2 3.2 643425 2.9 2.9 643448 2 . 8 2.8 643426 2.9 2.9 643415 3.0 3.0 643453 2.9 2.9 643330 2.5 2.5 643336 3.0 3 . 0 643387 2 . 9 2 . 9 643377 2 . 9 2.9 Day 38 2.0 1.9 1.8 1.7 2.1 2.3 2.0 2.0 2.1 1.7 1.9 1.8 2.1 1.8 2.1 2.1 2.0 2.1 2.1 2.2 2.2 1.9 2.3 2.1 1.9 2.4 2.4 2.3 1.8 1.9 2.4 2.3 2.2 1.8 1.9 2.4 2.2 2.1 2.2 2.2 2.2 1.9 2.2 2.2 2.1 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 41 Day 42 2 . 0 2.0 2.0 2.0 1.9 1.9 1.9 2.0 1.8 1.8 1.8 1.8 1.7 1.7 1.7 1.7 2.1 2.1 2.1 2.2 2.3 2.3 2.3 b 2.3 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 1.7 1.7 1.7 1.8 1 . 9 1.9 1.9 1.9 1.8 1.8 1.8 1.8 2 . 1 2 . 1 2.1 2.2 1.8 1.8 1.8 1.8 2.1 2 . 1 2.1 2.0 2 . 1 2.1 2.1 2.1 2.0 2.0 2.0 2.0 2 . 1 2 . 1 2.1 2.3 2 . 1 2 . 1 2 . 1 2.1 2.2 2.2 2.2 2 . 1 2.2 2.2 2.2 2.3 1.9 1 . 9 1.9 2.0 2.3 2 . 3 2.3 2.2 2 . 1 2.1 2 . 1 2.2 1.9 1.9 1.9 2.0 2.4 2.4 2.4 2.5 2 . 4 2.4 2.4 2.5 2 . 3 2 . 3 2 . 3 2.4 1.8 1.8 1.8 1.8 1.9 1 . 9 1.9 2.0 2 . 4 2.4 .4 2.4 2.3 2 . 3 2 . 3 2.3 2.2 2.2 2.2 2.2 1 . 8 1.8 1.8 1.9 1.9 1.9 1.9 2.0 2.4 2.4 2.4 2.6 2.2 2.2 2.2 2.2 2 . 1 2.1 2 . 1 2.1 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.2 2.2 2.2 2.3 1.9 1 . 9 1 . 9 2.0 2 . 2 2.2 2.2 2.3 2.2 2.2 2.2 2.2 2 , 1 2 . 1 2 . 1 2.2 Day 43 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 Day 44 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 23 2.2 1.9 2.0 2.6 2.2 2. 2.2 2.3 2.3 2.0 2.3 2.2 2.2 ) DuPont-5386 Day 45 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 4O, .J"3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 Company Sanitized. Does not contain TSCA CBI 536 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D a y 46 D a y 47 F e m a le , I I - 0 m g/ k g / d a y 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 to o 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 D a y 48 2.0 2.0 1.8 1.7 2.2 2.3 2.0 2.1 2.1 1.8 1.9 1.8 2.2 1.8 2.0 2.1 2.0 2.3 2.1 2.1 2.3 2.0 2.2 2.2 2.0 2.5 2.5 2.4 1.8 2.0 2.4 2.3 2.2 1.9 2.0 2.6 2.2 2.1 2.2 2.3 2.3 2.0 2.3 2.2 2.2 INDIVIDUAL DOSE VOLUMES D a y 49 D a y 50 D a y 51 2.0 2.0 2.0 2.1 2.1 2.1 1.9 1.9 1.9 1.8 1.8 1.8 2.4 2.4 2.4 2.3 2.3 2.3 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2 '. 1 2.1 1.9 1.9 1.9 2.0 2.0 2.0 1.9 1.9 1.9 2.2 2.2 2.2 1.9 1.9 1.9 2.1 2.1 2.1 2.2 2.2 2.2 2.1 2.1 2.1 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.1 2.1 2.1 2.4 2.4 2.4 2.3 2.3 2.3 2.0 2.0 2.0 2.6 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 1.8 1.8 1.8 2.0 2.0 2.0 2.6 2.6 2.6 2.4 2.4 2.4 2.3 2.3 2.3 2.0 2.0 2 . 0 2.0 2.0 2.0 2.7 2.7 2.7 2.3 2.3 2.3 2.1 2.1 2.1 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.4 2.0 2.0 2 . 0 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.3 537 (m L ) 52 Day 53 Day 54 DuPont-5386 Day 55 2.0 2.1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2 .1 2.4 2.2 2.2 2.3 2 .1 2.4 2.3 2 .0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2 .1 2 .3 2.4 2.4 2 .0 2.4 2.3 2.3 2.0 2 .1 1.9 1.8 2.4 2.3 2.0 2 .1 2 .1 1.9 2.0 1.9 2.2 1.9 2 .1 2.2 2.1 2.4 2.2 2.2 2.3 2 .1 2.4 2.3 2 .0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2 .1 2.3 2.4 2.4 2 .0 2.4 2.3 2.3 2.0 2 .1 1.9 1.8 2.4 2.3 2.0 2.1 2.1 1.9 2.0 1.9 2.2 1.9 2.1 2.2 2.1 2.4 2.2 2.2 2.3 2 .1 2.4 2.3 2.0 2.6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2 .1 2.3 2.4 2.4 2 .0 2.4 2.3 2.3 2.0 2.1 1.9 1 .8 2.4 2.3 2 .0 2 .1 2 .1 1.9 2.0 1.9 2.2 1.9 2 .1 2.2 2 .1 2.4 2.2 2.2 2.3 2.1 2.4 2.3 2 .0 2 .6 2.6 2.5 1.8 2.0 2.6 2.4 2.3 2.0 2.0 2.7 2.3 2 .1 2.3 2.4 2.4 2.0 2.4 2.3 2.3 Company SmBwL Does no, co,,|a|) TSCA^ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 56 Day 57 Female, II - 0 mg/ kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.0 2.1 1.9 1.9 2 .5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2 .1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2 .1 2.6 2 .7 2.6 2.0 2 .1 2.5 2.5 2 .3 2.0 2.1 2 .7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2 .4 2.4 2.0 2.1 1.9 1.9 2 .5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2 .1 2.3 2 .1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2 .1 2.6 2.7 2.6 2.0 2 .1 2.5 2.5 2 .3 2.0 2 .1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 Day 58 2.0 2.1 1.9 1.9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2 .1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2 .5 2.2 2 .1 2.6 2.7 2 .6 2.0 2.1 2.5 2.5 2.3 2.0 2 .1 2.7 2.4 2.3 2 .4 2.4 2.4 2.0 2.4 2.4 2 .4 INDIVIDUAL DOSE VOLUMES Day 59 Day 60 Day 61 2.0 2.1 1.9 1 .9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2 .1 2.4 2 .1 2.3 2.4 2.1 2 .5 2.2 2.1 2.6 2.7 2 .6 2.0 2 .1 2.5 2 .5 2.3 2.0 2 .1 2 .7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 2.0 2.1 1.9 1.9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2 .1 2.3 2 .1 2.4 2 .1 2.3 2.4 2 .1 2.5 2.2 2 .1 2.6 2 .7 2 .6 2.0 2 .1 2 .5 2.5 2.3 2 .0 2 .1 2.7 2.4 2.3 2.4 2 .4 2.4 2 .0 2.4 2.4 2.4 2.0 2 .1 1.9 1.9 2.5 2.5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1.9 2.1 2.3 2.1 2.4 2.1 2.3 2.4 2.1 2.5 2.2 2 .1 2.6 2 .7 2.6 2.0 2.1 2.5 2.5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2.0 2.4 2.4 2.4 538 (m L) 62 Day 63 Day 64 DuPont-5386 Day 65 2.0 2.1 1.9 1.9 2.5 2 .5 2.2 2.2 2.2 2.0 2.0 2.1 2.3 1 .9 2.1 2.3 2.1 2.4 2 .1 2.3 2.4 2.1 2 .5 2.2 2 .1 2 .6 2.7 2.6 2.0 2.1 2 .5 2 .5 2.3 2.0 2.1 2.7 2.4 2.3 2.4 2.4 2.4 2 .0 2.4 2.4 2.4 2 .1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2 .0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2.1 2.6 2 .5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2 .5 2.4 2.5 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2 .1 2.7 2.7 2 .6 1.9 2.1 2.6 2.5 2.4 2 .0 2 .1 2.7 2.4 2.3 2.4 2.6 2.4 2 .1 2 .5 2.4 2.5 2 .1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2.7 2.7 2.6 1.9 2.1 2.6 2.5 2.4 2 .0 2 .1 2.7 2.4 2.3 2.4 2.6 2.4 2.1 2 .5 2.4 2.5 Company Sanitized, Does not contain TSCA CB( ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 66 Day 67 Female, II - 0 mg / kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2 .1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2 .5 2.2 2.1 2.7 2.7 2.6 1.9 2 .1 2.6 2.5 2.4 2.0 2.1 2.7 2.4 2.3 2.4 2.6 2.4 2 .1 2.5 2.4 2.5 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2 .0 2.3 2.2 2.2 2.4 2.2 2 .5 2.2 2 .1 2.7 2.7 2.6 1.9 2 .1 2.6 2.5 2 .4 2.0 2 .1 2.7 2.4 2.3 2.4 2 .6 2.4 2 .1 2.5 2.4 2.5 Day 68 2 .1 2.2 2.0 2.0 2 .6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2 .5 2.2 2.1 2.7 2.7 2.6 1.9 2 .1 2.6 2 .5 2.4 2 .0 2.1 2.7 2 .4 2.3 2.4 2.6 2.4 2.1 2.5 2.4 2.5 INDIVIDUAL DOSE VOLUMES Day 69 Day 70 Day 71 2.1 2.2 2.0 2.0 2.6 2.5 2.2 2.2 2.3 2.0 2.0 2.1 2.3 1.9 2.2 2.2 2.0 2.3 2.2 2.2 2.4 2.2 2.5 2.2 2.1 2 .7 2.7 2.6 1.9 2 .1 2.6 2.5 2.4 2.0 2 .1 2.7 2.4 2.3 2.4 2.6 2.4 2 .1 2 .5 2 .4 2.5 2 .1 2.3 2 .1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2.1 2.7 2 .7 2.7 2.0 2 .1 2.6 2.5 2.4 2.0 2 .1 2.8 2.4 2.3 2 .5 2.8 2 .5 2 .1 2 .5 2.5 2.5 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2 .2 2.4 2.2 2 .5 2.3 2 .1 2 .7 2.7 2.7 2.0 2 .1 2.6 2 .5 2.4 2.0 2 .1 2.8 2.4 2.3 2.5 2.8 2 .5 2 .1 2.5 2 .5 2 .5 539 I (mL) Day 72 Day 73 Day 74 DuPont-5386 Day 7 5 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2 .1 2.7 2.7 2.7 2.0 2.1 2.6 2.5 2.4 2.0 2 .1 2.8 2.4 2.3 2.5 2 .8 2.5 2 .1 2.5 2.5 2.5 2.1 2.3 2.1 2.0 2.6 2 .5 2.2 2.2 2.3 2 .1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2 .1 2.7 2 .7 2.7 2.0 2 .1 2 .6 2 .5 2.4 2 .0 2 .1 2 .8 2.4 2.3 2 .5 2.8 2.5 2.1 2 .5 2.5 2.5 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2 .1 2.1 2.2 2.4 1.9 2.2 2.3 2.2 2.4 2.2 2.2 2.4 2.2 2.5 2.3 2 .1 2.7 2.7 2.7 2.0 2.1 2.6 2.5 2.4 2 .0 2.1 2.8 2.4 2.3 2.5 2.8 2 .5 2.1 2.5 2.5 2 .5 2.1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2.1 2.2 2.4 1.9 2.2 2 .8 2.4 2.3 2.5 2.8 2.5 2.1 2 .5 2.5 2.5 o-npavsanrazed. Does not contain TSCACBf ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 76 Day 77 E'emale, II - 0 mg/ kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2 .1 2.3 2.1 2.0 2.6 2.5 2.2 2.2 2.3 2.1 2 .1 2.2 2.4 1.9 2.2 2.8 2.4 2.3 2 .5 2.8 2.5 2 .1 2 .5 2.5 2.5 2 .1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2 .1 2 .0 2.2 2.4 2 .0 2.3 2.7 2 .4 2 .3 2.6 2 .9 2 .5 2 .1 2 .5 2.5 2 .6 Day 78 2 .1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2.0 2.2 2.4 2.0 2.3 2 .7 2.4 2.3 2.6 2.9 2 .5 2 .1 2.5 2.5 2.6 INDIVIDUAL DOSE VOLUMES Day 7 9 Day 80 Day 81 2.1 2 .1 2 .1 2.3 2.3 2.3 2.0 2.0 2.0 2.0 2.0 2.0 2.7 2.7 2.7 2.5 2 .5 2 .5 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.3 2.1 2.1 2 .1 2.0 2.0 2.0 2.2 2.2 2.2 2.4 2.4 2.4 2.0 2.0 2 .0 2.3 2.3 2.3 2.7 2 .7 2.7 2.4 2.4 2.4 2.3 2.3 2.3 2.6 2.6 2.6 2.9 2.9 2.9 2.5 2 .5 2.5 2.1 2 .1 2.1 2 .5 2.5 2 .5 2.5 2.5 2.5 2.6 2 .6 2.6 540 (mL) 82 Day 83 Day 84 DuPont-5386 Day 85 2 .1 2.3 2.0 2.0 2.7 2 .5 2.2 2.3 2.3 2 .1 2.0 2.2 2.4 2.0 2.3 2 .1 2.3 2.0 2.0 2.7 2.5 2.2 2.3 2.3 2.1 2 .0 2.2 2.4 2.0 2.3 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2 .1 2 .1 2.2 2.4 2 .0 2.3 2.2 2.4 2 .0 1.9 2 .8 2 .6 2.3 2.3 2.4 2 .1 2 .1 2.2 2.4 2.0 2.3 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.9 2.9 3.0 3.0 2.5 2.5 2.5 2.5 2.1 2.1 2.2 2.2 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.5 2.5 'w pany Sanitized, D oes n o , co n tain T sr j , . a .  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 86 Day 87 Female, II - 0 mg/ kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2.1 2.1 2.2 2.4 2.0 2.3 2.7 2.4 2.3 2.6 3.0 2.5 2.2 2.5 2.5 2.5 2.2 2.4 2.0 1.9 2 .8 2 .6 2.3 2.3 2.4 2 .1 2 .1 2.2 2.4 2 .0 2.3 2.7 2.4 2.3 2 .6 3.0 2 .5 2.2 2.5 2.5 2 .5 Day 88 2.2 2.4 2.0 1.9 2.8 2 .6 2.3 2.3 2.4 2 .1 2.1 2.2 2.4 2 .0 2.3 2.7 2.4 2.3 2.6 3 .0 2.5 2.2 2.5 2.5 2.5 INDIVIDUAL DOSE VOLUMES (mL) Day 89 Day 90 Day 91 Day 92 2.2 2.4 2.0 1.9 2.8 2 .6 2.3 2.3 2.4 2.1 2 .1 2.2 2.4 2.0 2.3 2.2 2.4 2.0 1.9 2.8 2.6 2.3 2.3 2.4 2.1 2.2 2.5 2.1 1.9 3.0 2.6 2.3 2.4 2.3 2.2 2.2 2 .5 2.1 1.9 3.0 2.6 2.3 2.4 2.3 2.2 2.7 2.4 2 .3 2.6 3.0 2 .5 2.2 2.5 2.5 2.5 541 ) DuPont-5386 Company Sanitized. Does nt contain TSCACBi )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Day 2 Female, IV - 2 5 m g / kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 1.7 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2 .1 2.2 2 .0 1 .7 1 .9 2.0 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 AK TEST 2.1 1.7 1.9 1.8 1.7 2 .1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2 .0 2.1 2.2 2.0 1.7 1.9 2.0 DAY 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 0 2.1 1.7 1.9 1 .8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1 .9 1 .9 2.0 2.1 2.2 2.0 1 .7 1.9 2.0 Day 3 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2.1 2.2 2.0 1.7 1.9 2.0 INDIVIDUAL DOSE VOLUME Day 4 Day 5 Day 6 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1 .9 1.8 1.7 2 .1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2 .1 2 .2 2.0 1 .7 1.9 2 .0 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2 .1 2.0 2.1 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2.0 2 .1 2.2 2.0 1.7 1.9 2.0 1.8 2.0 1.7 1.9 1.8 1.9 1.9 1.8 1.8 1.8 1.8 2.1 1.7 1.9 1.8 1.7 2.1 2.0 ni 2.0 2.0 2.3 1.9 2.2 1.9 1.9 1.9 2 .0 2.1 2.2 2.0 1.7 1.9 2.0 542 IS (m L ) Day 7 Day 8 Day 9 DuPont-5386 Day 10 Day 11 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2.0 2 .0 1 .9 2.4 2.2 2.3 2.3 2.2 2 .6 2.1 2.5 2.2 2.3 2.2 2.3 2.2 2.5 2.2 1.9 2.1 2.3 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2 .0 1.9 1.9 2 .0 2.2 1.9 2.0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2.3 2.2 2.3 2.2 2 ,5 2.2 1.9 2.1 2.3 1.9 2.3 1.9 2.2 2 .1 2.3 2.1 2.0 1.9 1.9 2 .0 2.2 1.9 2.0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2 .1 2.5 2.2 2.3 2.2 2.3 2.2 2.5 2.2 1.9 2.1 2.3 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2.0 2 .0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2.3 2.2 2.3 2.2 2.5 2.2 1.9 2.1 2.3 1.9 2.3 1.9 2 .2 2 .1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2 .0 2 .0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2.3 2.2 2.3 2.2 2.5 2.2 1.9 2.1 2.3 Company Sanitized. Doe* ____________________ 65 not contain TSCAr.R. ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 12 Day 13 Female, IV - 2 5 m g / kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2.0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2.1 2.5 2.2 2.3 2.2 2.3 2.2 2 .5 2.2 1.9 2.1 2.3 1.9 2.3 1.9 2.2 2.1 2.3 2.1 2.0 1.9 1.9 2.0 2.2 1.9 2.0 2.0 1.9 2.4 2.2 2.3 2.3 2.2 2.6 2 .1 2 .5 2.2 2.3 2.2 2 .3 2.2 2.5 2.2 1 .9 2.1 2.3 Day 14 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2 .1 2.1 2.4 2.1 2.2 2.3 2 .1 2.6 2.4 2.5 2.5 2.4 2 .7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2 .0 2.3 2.5 Day 15 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2 .5 INDIVIDUAL DOSE VOLUMES Day 16 Day 17 Day 1 8 ` 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2 .1 2.4 2.1 2.2 2.3 2 .1 2.6 2.4 2 .5 2.5 2.4 2.7 2.3 2.7 2.3 2 .5 2.4 2.6 2.4 2 .5 2.4 2 .0 2.3 2 .5 2.0 2.5 2.3 2.4 2.2 2.4 2 .1 2.2 2.2 2.1 2 .1 2.4 2.1 2.2 2 .3 2 .1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2 .0 2.3 2.5 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2.1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2 .4 2.5 2.4 2 .0 2 .3 2.5 543 ) (mL) Day 19 Day 20 Day 21 Day 22 DuPont-5386 Day 23 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2 .1 2.1 2.4 2.1 2.2 2.3 2.1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2.0 2.3 2.5 2.0 2.5 2.3 2.4 2.2 2.4 2.1 2.2 2.2 2 .1 2.1 2.4 2 .1 2.2 2.3 2 .1 2.6 2.4 2.5 2.5 2.4 2.7 2.3 2.7 2.3 2.5 2.4 2.6 2.4 2.5 2.4 2 .0 2.3 2 .5 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2 .3 2.3 2.3 2.7 2.2 2 .5 2.4 2.4 2 .8 2 .6 2.7 2.7 2.5 3.0 2.4 3 .0 2.6 2.7 2 .6 2.8 2.7 2 .8 2.6 2.1 2 .5 2.6 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3 .0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 2 .1 2.5 2.6 2.2 2 .8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2 .5 2.4 2.4 2.8 2 .6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2 .6 2.8 2.7 2.8 2.6 2 .1 2.5 2.6 Company Sanitized. Does not contain TSCA C B l i)I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________________________________ DuPont-5386 Day 24 Day 25 Female, IV - 2 5 mg / kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 21 2.5 2 .6 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2.6 2.8 2.7 2.8 2.6 n, j1. 2.5 2.6 Day 26 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3 .0 2.4 3.0 2.6 2.7 2 .6 2.8 2.7 2.8 2.6 2.1 2.5 2 .6 Day 27 2.2 2.8 2.5 2.7 2.4 2.6 2.3 2.4 2.3 2.3 2.3 2.7 2.2 2.5 2.4 2.4 2.8 2.6 2.7 2.7 2.5 3.0 2.4 3.0 2.6 2.7 2 .6 2.8 2.7 2.8 2.6 2.1 2.5 2.6 INDIVIDUAL DOSE VOLUMES (mL) Day 28 Day 2 9 Day 3 0 Day 31 2.4 2.8 2.7 2.9 2.4 2.7 2.4 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2 .6 2 .7 2.4 2.4 2.4 2.8 2.8 2.8 2.7 2.7 2.7 2.9 2.9 2.9 2.4 2.4 2.4 2.7 2.7 2.7 2 . 4 SE TEST DAY 2 9 2.6 2.6 2.6 2.4 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.7 2.7 2.7 2.3 2.3 2.3 2.5 2.5 2.5 2.6 2.6 2.6 2.5 2.5 2.5 2.9 2.9 2.9 2.9 2.9 2.9 2.8 2.8 2.8 2.9 2.9 2.9 2.8 2.8 2.8 3.1 3.1 3.1 2.6 2.6 2.6 3.1 3.1 3.1 2.6 2 .6 2.6 2.8 2.8 2.8 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 3.0 2.9 2.9 2.9 2.8 2.8 2.8 2.3 2.3 2.3 2.6 2.6 2.6 2.7 2.7 2.7 Day 32 2.4 2.8 2.7 2.9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 Day 33 2.4 2.8 2.7 2.9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2.6 2.7 Day 3 4 Day 3 5 2.4 2.8 2.7 2.9 2.4 2.7 2.6 2.4 2.4 2.3 2.7 2.3 2.5 2.6 2.5 2.9 2.9 2.8 2.9 2.8 3.1 2.6 3.1 2.6 2.8 2.7 3.0 3.0 2.9 2.8 2.3 2 .6 2.7 2.5 3.0 2.8 2.9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3.0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 Company Sanitized. Does not contain TSCA CB! 544 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 3 6 Day 37 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.5 3.0 2.8 2.9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3.0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 2.5 3.0 2.8 2.9 2.6 2.9 2.7 2.6 2.5 2.5 2.8 2.4 2.6 2.7 2.6 3.0 2.9 2.8 3.0 2.9 3.5 2.7 3.2 2.8 3.0 2.7 3.1 3.1 3.0 2.9 2.4 2.7 2.8 Day 3 8 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2 .1 1.8 2.0 2.1 INDIVIDUAL DOSE VOLUMES (mL) Day 3 9 Day 40 Day 41 Day 42 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2 .1 1.8 2.0 2.1 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1 .9' 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2.3 2.3 2 .1 1.8 2.0 2.1 1.9 2.3 2.1 2.2 2.0 2.2 2.0 1.9 1.9 1.9 2.1 1.8 2.0 2.0 2.0 2.3 2.2 2.1 2.2 2.1 2.6 2.0 2.4 2.1 2.2 2.1 2.3 2 .3 2.3 2.1 1.8 2.0 2.1 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2 .5 2.2 1.9 2.0 2.2 Day 43 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 Day 4 4 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 DuPont-5386 Day 45 1 .9 2 .3 2 .1 2 .3 2 .1 2 .3 2 .0 2 .0 1 .9 1 .9 2 .1 1 .9 2 .1 2 .1 2 .0 2 .4 2 .1 2 .2 2 .4 2 .2 2 .8 2 .2 2 .5 2 .1 2 .3 2 .2 2 .4 2 .4 2 .5 2 .2 1 .9 2 .0 2 .2 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 46 Day 47 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2.2 1.9 2.0 2.2 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1 .9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2 .2 1 .9 2.0 2.2 Day 48 1.9 2.3 2.1 2.3 2.1 2.3 2.0 2.0 1.9 1.9 2.1 1.9 2.1 2.1 2.0 2.4 2.1 2.2 2.4 2.2 2.8 2.2 2.5 2.1 2.3 2.2 2.4 2.4 2.5 2 .2 1.9 2.0 2.2 INDIVIDUAL DOSE VOLUMES Day 49 Day 50 Day 51 2.0 2.3 2.2 2.3 2.1 2.3 2.0 2.3 2.2 2.3 2.1 2.3 2.0 2.3 2.2 2.3 2.1 2.3 2.1 2.1 2.1 2.0 2.0 2.0 2.0 2 .0 2 .0 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2 .1 2.2 546 ) (mL) 52 Day 53 Day 54 DuPont-5386 Day 55 2.0 2.3 2.2 2.3 2 .1 2.3 2 .1 2 .0 2.0 2.0 2.3 1.9 2 .1 2.2 2 .1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2 .1 2.2 2 .0 2.3 2.2 2.3 2 .1 2.3 2 .1 2.0 2.0 2.0 2.3 1.9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 2.0 2.3 2.2 2.3 2.1 2.3 2 .1 2.0 2 .0 2.0 2.3 1.9 2.1 2.2 2 .1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2 .5 2.0 1.9 2 .1 2.2 2.0 2.3 2.2 2.3 2.1 2.3 2 .1 2.0 2.0 2 .0 2.3 1 .9 2.1 2.2 2.1 2.4 2.3 2.2 2.4 2.2 2.9 2.2 2.5 2.2 2.4 2.2 2.5 2.4 2.5 2.0 1.9 2.1 2.2 Company Sanitized. Does not contain TSCA CB1 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 56 Day 57 Female, IV - 2 5 m g / kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2.0 2 .1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2 .9 2 .2 2.7 2.2 2 .4 2.3 2.6 2.5 2.4 2 .2 2.0 2.1 2.2 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2 .0 2.1 2.2 2 .1 2.4 2.3 2.3 2 .5 2.2 2 .9 2.2 2 .7 2.2 2.4 2 .3 2 .6 2 .5 2.4 2.2 2.0 2 .1 2.2 Day 58 2 .1 2.4 2.4 2.4 1.8 2.4 2.2 2 .1 2.0 1.9 2.2 2 .0 2.1 2.2 2.1 2.4 2.3 2.3 2 .5 2.2 2 .9 2.2 2.7 2 .2 2.4 2.3 2 .6 2.5 2.4 2.2 2.0 2.1 2 .2 INDIVIDUAL DOSE VOLUMES Day 59 Day 60 Day 61 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2 .0 1.9 2.2 2.0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2.3 2.6 2.5 2.4 2.2 20 2.1 2.2 2.1 2.4 2.4 2.4 1 .8 2.4 2.2 2.1 2.0 1.9 2.2 2 .0 2.1 2.2 2.1 2.4 2.3 2.3 2.5 2.2 2 .9 2.2 2.7 2.2 2.4 2.3 2 .6 2 .5 2.4 2.2 zo,. <nj 2 .1 2.2 2.1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2 .0 2.1 2.2 2 .1 2.4 2.3 2.3 2.5 2.2 2 .9 2.2 2.7 2.2 2.4 2.3 2.6 2 .5 2.4 2.2 2.0 2 .1 2.2 547 ) (m L ) 62 Day 63 Day 64 DuPont-5386 Day 65 2 .1 2.4 2.4 2.4 1.8 2.4 2.2 2.1 2.0 1.9 2.2 2.0 2 .1 2.2 2 .1 2.4 2.3 2.3 2.5 2.2 2.9 2.2 2.7 2.2 2.4 2 .3 2 .6 2 .5 2.4 2.2 2 .0 2 .1 2.2 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2 .1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2 .1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2 .5 2.2 2.0 2.2 2.3 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2 .1 2.1 2.0 2.3 2 .1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 Company Sanitized, Does no! contain TSCA CBt ) 11-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 66 Day 67 Female, IV - 2 b m g / kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2 .1 2.5 2.3 2.5 2.2 2.3 2.2 2 .1 2.1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2 .3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2.1 2 .0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2 .2 2.3 Day 68 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2 .1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2.3 INDIVIDUAL DOSE VOLUMES Day 69 Day 70 Day 71 2.1 2.5 2.3 2.5 2.2 2.3 2.2 2.1 2 .1 2.0 2.3 2.1 2.2 2.2 2.2 2.5 2.3 2.2 2.5 2.3 2.9 2.2 2.7 2.3 2.4 2.3 2.7 2.6 2.5 2.2 2.0 2.2 2 .3 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2 .1 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2.0 2.2 2.3 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2 .0 2.2 2.3 548 (m L ) 72 Day 73 Day 74 DuPont-5386 Day 75 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2 .1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2 .0 2.2 2.3 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 b 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2 .5 2.3 2.0 2.2 2.3 2 .1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2.1 2.3 2.3 2.2 2.5 2.4 2.3 2.5 2.4 3.0 2.3 2.7 2.2 2.4 2.3 2.7 2.6 2.5 2.3 2.0 2.2 2.3 2 .1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2 .1 2.0 2.3 2.1 2.3 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 76 Day 77 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.1 2.6 2.4 2.6 2.3 2.4 2.2 2.2 2.1 2.0 2.3 2.1 2.3 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2 .1 2.2 Day 78 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2 .0 2.3 2 .1 2.2 INDIVIDUAL DOSE VOLUMES (mL) Day 7 9 Day 80 Day 81 Day 82 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2 .1 2.2 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2 .3 2 .1 2.2 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2 .0 2.3 2 .1 2.2 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2 .1 2.2 Day 83 2.2 2.7 2.4 2.6 2.2 2.4 2.2 2.3 2.2 2.0 2.3 2 .1 2.2 Day 84 2.2 2 .7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2 .1 2.3 DuPont-5386 Day 8 5 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2 .0 2.3 2.1 2.3 Company Sanitized. Does not contain TSCA CB 549 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 86 Day 87 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2.1 2.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2.1 2.3 Day 88 INDIVIDUAL DOSE VOLUMES (mL) Day 89 Day 90 Day 91 Day 92 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.0 2.3 2 .1 0.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2 .0 2.3 2 .1 2.3 2.2 2.7 2.5 2.6 2.2 2.4 2.3 2.2 2.2 2.2 2.7 2.5 2 .7 2.2 2.4 2.3 2.3 2.2 2.2 2.7 2 .5 2.7 2.2 2.4 2.3 2.3 2.2 DuPont-5386 Company Sanitized. Does not contain TSCA CB 550 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 1 .9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1 .7 1.9 1.9 1 .9 2.0 2.0 2.0 1.8 1.9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 Day 2 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1,9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 Day 3 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1 .7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 INDIVIDUAL DOSE VOLUMI Day 4 Day 5 Day 6 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1 .7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1 .8 1.8 1.8 1.6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1 .9 2.0 2.0 2.0 1.8 1 .9 1.9 1.8 1.7 1.7 1.9 2.1 2.0 1.6 1.7 1.7 1.8 1.8 1.8 1 .6 1.9 1.8 1.8 2.2 1.9 1.9 2.0 1.8 1.8 2.1 1.8 2.1 1.7 1.9 1.9 1.9 2.0 2.0 2.0 1.8 1.9 551 ) IS (mL) Day 7 Day 8 Day 9 DuPont-5386 Day 10 Day 11 2.1 2.0 2 .0 2 .0 2.2 2 .6 2.3 1.8 2.0 1.9 2.1 2.0 2 .1 1.8 2.3 2.1 2 .1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2.1 2.2 2 .0 2.1 2 .1 2.0 2.2 2 .2 2.2 2 .1 2.2 2.1 2.0 2.0 2.0 2.2 2 .6 2.3 1.8 2.0 1.9 2 .1 2.0 2 .1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2 .1 2.2 2 .0 2 .1 2 .1 2 .0 2.2 2.2 2 .2 2 .1 2 .2 2.1 2 .0 2.0 2 .0 2.2 2.6 2.3 1.8 2.0 1.9 2 .1 2.0 2.1 1.8 2.3 2 .1 2 .1 2.4 2.2 2.2 2.2 2 .1 2.0 2.4 2 .1 2.2 2 .0 2 .1 2 .1 2 .0 2.2 2.2 2 .2 2 .1 2.2 2 .1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2 .0 1.9 2.1 2.0 2 .1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2 .1 2 .0 2.4 2 .1 2.2 2.0 2 .1 2.1 2.0 2.2 2.2 2 .2 2 .1 2.2 2.1 2.0 2.0 2 .0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2 .1 2 .1 2.4 2.2 2.2 2.2 2 .1 2 .0 2.4 2.1 2.2 2 .0 2.1 2 .1 2.0 2.2 2.2 2 .2 2 .1 2.2 Company Sanitized. Does not contain TSCA CBI !I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2 .1 1.8 2.3 2 .1 2.1 2.4 2.2 2.2 2.2 2.1 2.0 2.4 2 .1 2.2 2 .0 2 .1 2 .1 2.0 2.2 2.2 2 .2 2 .1 2.2 2.1 2.0 2.0 2.0 2.2 2.6 2.3 1.8 2.0 1.9 2.1 2.0 2.1 1.8 2.3 2.1 2.1 2.4 2.2 2.2 2.2 2 .1 2 .0 2.4 2 .1 2.2 2 .0 2 .1 2 .1 2.0 2.2 2 .2 2 .2 2 .1 2.2 Day 14 2.3 2.2 2.2 2 .1 2.3 2.8 2.5 2 .0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2 .5 2.3 2.2 2.6 2 .3 2.5 2 .1 2.3 2.3 2.3 2.3 2.5 2 .4 2.3 2 .5 Day 15 2.3 2.2 2.2 2.1 2.3 2.8 2 .5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2 .5 2.3 2.2 2.6 2.3 2.5 2 .1 2.3 2.3 2.3 2.3 2 .5 2.4 2.3 2 .5 INDIVIDUAL DOSE VOLUMI Day 16 Day 17 Day 18 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2 .5 2.3 2.2 2 .6 2 .3 2.5 2.1 2.3 2.3 2 .3 2.3 2 .5 2.4 2.3 2 .5 2.3 2.2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2.8 2.4 2.3 2 .5 2.3 2.2 2.6 2.3 2.5 2 .1 2.3 2.3 2.3 2.3 2 .5 2 .4 2.3 2.5 2.3 2.2 2.2 2 .1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2 .0 2.4 2.3 2.2 2 .8 2.4 2.3 2 .5 2.3 2 .2 2 .6 2 .3 2.5 2.1 2.3 2.3 2.3 2.3 2 .5 2 .4 2 .3 2 .5 552 IS (mL) Day 19 Day 20 2.3 2.2 2.2 2 .1 2.3 2.8 2.5 2.0 2 .1 2 .1 2.3 2 .1 2.2 2 .0 2.4 2.3 2.2 2 .8 2.4 2.3 2.5 2.3 2.2 2 .6 2.3 2.5 2 .1 2.3 2 .3 2.3 2.3 2 .5 2.4 2.3 2.3 2 .2 2.2 2.1 2.3 2.8 2.5 2.0 2.1 2.1 2.3 2.1 2.2 2.0 2.4 2.3 2.2 2 .8 2.4 2.3 2.5 2.3 2.2 2.6 2.3 2.5 2 .1 2.3 2.3 2.3 2.3 2.5 2.4 2.3 2 .5 DuPont-5386 21 Day 22 Day 23 2 .5 2 .4 2 .3 2 .3 2 .6 2 .9 2 .7 2 .1 2 .2 2 .3 2 .5 2 .3 2 .4 2 .2 2 .7 2 .5 2 .4 2 .8 2 .5 2 .4 2 .7 2 .3 2 .3 2 .9 2 .4 2 .7 2 .2 2 .4 2 .5 2 .4 2 .5 2 .6 2 .5 2 .4 2 .6 2 .5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2 .3 2.3 2.9 2.4 2.7 2.2 2.4 2 .5 2.4 2.5 2.6 2.5 2.4 2.6 2.5 2.4 2.3 2.3 2 .6 2 .9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2 .5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2 .9 2.4 2 .7 2.2 2.4 2.5 2.4 2.5 2 .6 2 .5 2.4 2.6 lO <N Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 24 Day 25 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2 .5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2 .5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2 .5 2.4 2 .5 2 .6 2.5 2.4 2 .6 2.5 2.4 2.3 2.3 2.6 2 .9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2 .5 2.6 2.5 2.4 2.6 Day 26 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2.5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2 .5 2 .6 2.5 2.4 2.6 Day 27 2.5 2.4 2.3 2.3 2.6 2.9 2.7 2.1 2.2 2.3 2.5 2.3 2.4 2.2 2.7 2.5 2.4 2.8 2 .5 2.4 2.7 2.3 2.3 2.9 2.4 2.7 2.2 2.4 2.5 2.4 2 .5 2 .6 2.5 2.4 2.6 INDIVIDUAL DOSE VOLUMES Day 28 Day 29 Day 30 2.6 2.6 2.6 2.4 2.4 2.4 2.5 2 .5 2 .5 2.5 2.5 2.5 2.7 2 .7 2.7 3.0 3.0 3.0 2.8 2.8 2.8 2.2 2.2 2.2 2.3 2.3 2.3 2.4 2.4 2.4 2.5 2.5 2.5 2.0 2.0 2.0 2.4 2.4 2.4 2.3 2 .3 2.3 2.8 2.8 2.8 2.6 2 .6 2 .6 2.6 2.6 2.6 3.0 3.0 3 .0 2.6 2.6 2.6 2.6 2 .6 2 .6 2.8 2 .8 2 .8 2.6 2.6 2.6 2.4 2.4 2.4 3.1 3 .1 3.1 2.6 2.6 2.6 2.9 2.9 2.9 2.5 2.6 2.5 2.6 2.6 2.8 2.6 2.4 2.8 2 .5 2.6 2.5 2 .6 2 .6 2 .8 2 .6 2 .4 2 .8 2 .5 2 .6 2 .5 2.6 2 .6 2 .8 2 .6 2.4 2 .8 553 ) DuPont-5386 Day 33 Day 34 Day 3 5 6 2.6 4 2.4 2.6 2.4 5 2.5 5 2.5 7 2.7 2.5 2.5 2.7 0 3.0 3.0 8 2 .8 2.8 2 2.2 2.2 3 2.3 2.3 4 2.4 2.4 5 2.5 2.5 0 2.0 2.0 4 2.4 2.4 3 2.3 2.3 8 2.8 2.8 6 2.6 2.6 6 2 .6 2 .6 0 3.0 3.0 6 2.6 2.6 6 2.6 2.6 8 2.8 2.8 6 2.6 2.6 4 2.4 2.4 1 3 .1 3.1 6 2 .6 2 .6 9 2.9 2.9 5 2 .5 2 . 5 6 2.6 2.6 5 2.5 2.5 6 2.6 2.6 6 2.6 2.6 8 2.8 2.8 6 2.6 4 2.4 2.6 2.4 8 2.8 2.8 2.7 2.6 2.6 2.6 2 .8 3.2 2.9 2.4 2.4 2.5 2.6 2.0 2.5 2.2 2.8 2.8 2.6 3.1 2.8 2.7 2.9 2.7 2.5 2.8 2.6 3.0 b 2.5 2.7 2.7 2.7 2.7 2.9 2.8 2.6 2.9 Company Sanitized. Does not contain TSC A CB l H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 36 Day 37 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.7 2.6 2.6 2.6 2.8 3.2 2.9 2.4 2.4 2.5 2.6 2.0 2.5 2.2 2.8 2.8 2.6 3.1 2.8 2.7 2.9 2.7 2 .5 2.8 2.6 3.0 2.5 2.7 2.7 2.7 2.7 2.9 2 .8 2.6 2.9 2.7 2.6 2.6 2.6 2.8 3.2 2.9 2.4 2.4 2 .5 2.6 2.0 2.5 2.2 2.8 2.8 2.6 3.1 2.8 2.7 2.9 2.7 2 .5 2.8 2.6 3.0 2 .5 2.7 2.7 2.7 2.7 2 .9 2 .8 2.6 2 .9 Day 3 8 2.0 2.0 2.0 2.0 2.1 2.4 2.2 1.8 1.8 1.9 1.9 1.5 1.9 1.7 2.1 2.1 2.0 2.3 2.1 2 .1 2.2 2.0 1.9 2 .1 2.0 2.2 1.9 2.0 2.0 2.0 2 .1 2.2 2 .1 2.0 2.2 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 4 0 Day 41 Day 42 2.0 2.0 2.0 2.0 2 .1 2.4 2.2 1.8 1.8 1.9 1.9 1.5 1.9 1.7 2 .1 2.1 2.0 2.3 2.1 2 .1 2.2 2.0 1.9 2 .1 2.0 2.2 1.9 2 .0 2 .0 2 .0 2 .1 2.2 2 .1 2 .0 2.2 2.0 2.0 2 .0 2.0 2 .1 2.4 2.2 1.8 1.8 1-9 . 1.9 1 .5 1.9 1.7 2.1 2.1 2.0 2.3 2.1 2.1 2.2 2 .0 1.9 2 .1 2.0 2.2 1.9 2.0 2 .0 2.0 2 .1 2.2 2.1 2.0 2.2 2.0 2.0 2.0 2.0 2 .1 2.4 2.2 1.8 1.8 1.9 1 .9 1.5 1.9 1.7 2.1 2.1 2.0 2.3 2 .1 2.1 2.2 2.0 1.9 2.1 2.0 2.2 1.9 2 .0 2 .0 2.0 2 .1 2.2 2 .1 2 .0 2.2 2.1 2.0 2.0 2 .1 2 .1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2 .1 2.1 2.2 2 .1 2.0 2 .1 2.0 2.3 2.0 2 .1 2 .1 2 .1 2.1 2 .3 2 .2 2 .0 2.3 Day 43 2.1 2.0 2.0 2.1 2 .1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2 .0 1.9 2.3 2.2 2.1 2.4 2 .1 2.1 2.2 2.1 2 .0 2 .1 2 .0 2.3 2.0 2 .1 2 .1 2 .1 2.1 2.3 2.2 2 .0 2.3 Day 44 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2 .1 2 .0 2.3 2.0 2 .1 2 .1 2.1 2.1 2.3 2 .2 2.0 2.3 DuPont-5386 Day 45 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2 .1 2.0 2.3 2 .0 2.1 2.1 2.1 2.1 2.3 2 .2 2 .0 2.3 lompany Sanitized. Does not contain TSC A CBl I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 46 Day 47 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2 .1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2.1 2.1 2.3 2 .2 2.0 2.3 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2 .1 2 .1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2 .1 2 .1 2.3 2 .2 2 .0 2.3 Day 48 2.1 2.0 2.0 2.1 2.1 2.5 2.2 1.9 1.9 2.0 2.0 1.4 2.0 1.9 2.3 2.2 2.1 2.4 2.1 2.1 2.2 2.1 2.0 2.1 2.0 2.3 2.0 2.1 2.1 2 .1 2 .1 2.3 2 .2 2 .0 2.3 INDIVIDUAL DOSE VOLUMES Day 49 Day 50 Day 51 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2 .1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2 .1 2.2 2.2 2.3 2.3 2 .1 2.3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2.1 2 .3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2 .1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2 .1 2.2 2 .1 2.2 2.2 2.3 2 .3 2.1 2.3 555 ) (m L ) 52 Day 53 Day 54 DuPont-5386 Day 55 2.1 2.1 2.0 2 .1 2.2 2.4 2.2 1.9 1 .9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2 .3 2.1 2.4 2.1 2.2 2 .1 2.2 2.2 2.3 2 .3 2.1 2 .3 2.1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1 .9 2.0 1.7 2.0 1.9 2.3 2.2 2 .1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2 .1 2.2 2.2 2.3 2 .3 2.1 2.3 2.1 2 .1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2 .1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2.3 2 .1 2.3 2 .1 2.1 2.0 2.1 2.2 2.4 2.2 1.9 1.9 1.9 2.0 1.7 2.0 1.9 2.3 2.2 2.1 2.4 2.2 2.3 2.3 2.2 2.0 2.3 2.1 2.4 2.1 2.2 2.1 2.2 2.2 2.3 2 .3 2.1 2.3 Company Sanitized. Does not contain TSCA CBI I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 56 Day 57 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2 .1 2.3 2.2 2.2 2.2 2.4 2 .3 2.0 2.3 2.1 2.2 2.0 2.1 2.2 2.4 2 .3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2 .3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2 .1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 Day 58 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2 .1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 INDIVIDUAL DOSE VOLUMES Day 59 Day 60 Day 61 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2 .3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2 .3 2.0 2.3 2.1 2 .2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2 .3 2.0 2.3 2.1 2.2 2.0 2.1 2.2 2.4 2 .3 1.9 1 .9 2.0 2.1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2 .3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 556 I (mL) 62 Day 63 Day 64 DuPont-5386 Day 65 2.1 2.2 2.0 2.1 2.2 2.4 2.3 1.9 1.9 2.0 2 .1 1.7 2.0 1.9 2.2 2.3 2.1 2.3 2.2 2.3 2.3 2.2 2.1 2.3 2.1 2.4 2.1 2.3 2.2 2.2 2.2 2.4 2.3 2.0 2.3 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 2.2 2.2 2.0 2.2 2.2 2.5 2 .3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2 .1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 Company Sanitized. Does not contain T S C A C B t ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 66 Day 67 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2 .0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2 .1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2 .3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2.4 2.3 2.1 2.4 Day 68 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2 .3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2.1 2.3 2.1 2 .4 2.3 2.1 2.4 INDIVIDUAL DOSE VOLUMES Day 69 Day 70 Day 7 1 2.2 2.2 2.0 2.2 2.2 2.5 2.3 2.0 2.0 2.1 2.1 1.8 2.1 1.9 2.3 2.3 2.2 2.4 2.2 2.3 2.3 2.2 2.0 2.4 2.1 2.5 2.1 2.3 2 .1 2 .3 2.1 2.4 2.3 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2 .4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2 .3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2 .1 2.5 2 .1 2.4 2 .2 2.4 2 .2 2.3 2.1 2.4 2.4 2.1 2.4 557 ) (mL) 72 Day 73 Day 74 DuPont-5386 Day 7 5 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2 .1 2.5 2.1 2.4 2.2 2.4 2 .2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2 . 12.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.4 2.2 2.4 2.2 2.4 2.4 2.3 2.1 2.5 2.1 2.4 2.2 2.4 2.2 2.3 2.1 2.4 2.4 2.1 2.4 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 76 Day 77 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 6 4 34 /0 643434 643349 643454 643333 643460 2.2 2.3 2.0 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 Day 78 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2 .0 2.2 2.2 1.9 2 .1 2.0 2.4 INDIVIDUAL DOSE VOLUMES (mL) Day 79 Day 80 Day 81 Day 82 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.0 1.9 2.1 2.0 2.4 2.2 2.4 2 .1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 b 2.2 1.9 2 .1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 Day 83 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.1 2.0 2.2 2.2 1.9 2.1 2.0 2.4 Day 84 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 DuPont-5386 Day 85 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 86 Day 87 Female, VI - 1 0 0 mg/ kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 Day 88 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 INDIVIDUAL DOSE VOLUMES (mL) Day 89 Day 90 Day 91 Day 92 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2.3 1.9 2.2 2.0 2.3 2.2 2.4 2.1 2.3 2.3 2.4 2.4 2.0 2.0 2.2 2 .2 2.4 2.1 2.3 2.4 2.5 2.4 2.1 2.0 2.1 2.2 2.4 2.1 2.3 2.4 2.5 2.4 2.1 2.0 2.1 DuPont-5386 Company Sanitized. Does not contain TSCA CBI )) H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 1 Day 2 Female, VIII - 2 5 0 mg/ kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1 .9 2.2 2.0 1.9 1.8 2 .1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 Day 3 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 INDIVIDUAL DOSE VOLUMI Day 4 Day 5 Day 6 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 1.9 2.0 2.0 1.8 1.7 1.7 1.7 1.9 1.8 2.0 1.7 2.0 1.8 1.6 2.2 2.0 1.8 2.2 1.8 2.0 2.1 1.8 2.1 1.8 1.9 1.9 2.0 2.1 2.1 2.0 1.7 1.9 2.2 2.0 1.9 1.8 2.1 1.9 1.8 1.9 1.9 2.0 1.7 1.9 1.7 560 I 2S (mL) Day 7 Day 8 Day 9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2 .2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2 .3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2 .2 2.3 1.9 2.2 1.9 DuPont-5386 10 Day 1 1 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2 .1 2.1 2.1 1 .9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2 .3 2.0 2.3 2.0 2.2 2.2 2.3 2.5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2 .5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 Company Sanitized. Does not contain TSC A CBf )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 12 Day 13 Day 14 Female, VIII - 2 5 0 mg/ kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2 .3 2.5 2.5 2.3 2.0 2.2 2 .4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.1 2.4 2.2 2.0 1.9 1.9 1.9 2.1 2.1 2.1 1.9 2.2 2.1 1.9 2.5 2.3 2.0 2.5 2.1 2.2 2.3 2.0 2.3 2.0 2.2 2.2 2.3 2 .5 2.5 2.3 2.0 2.2 2.4 2.3 2.1 2.0 2.5 2.1 2.0 2.1 2.2 2.3 1.9 2.2 1.9 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2 .4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2 .7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2 .4 2.2 2.4 2.2 Day 15 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2 .2 2.4 2.2 INDIVIDUAL DOSE VOLUM: Day 16 Day 17 Day 18 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2 .5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2 .2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 561 ES (mL) Day 1 9 Day 2 0 Day 21 Day 2 2 DuPont-5386 Day 23 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2.5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2.3 2.3 2.4 2.4 2.2 2.4 2.2 2.3 2.6 2.5 2.2 2.2 2.0 2.1 2.4 2.4 2.4 2.1 2.4 2.2 2.0 2.7 2.4 2.1 2.8 2.2 2.3 2.4 2.2 2.6 2.2 2.4 2.3 2 .5 2.7 2.8 2.6 2.2 2.3 2.8 2.6 2.3 2.2 2.7 2.3 2 .3 2.3 2.4 2.4 2.2 2.4 2.2 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2 .5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2 .6 2.9 2.9 2.7 2.4 2.5 2.9 2 .7 2.5 2.2 2.9 2.3 2.4 2.4 2 .5 2.6 2 .2 2 .6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2,4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2 .6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2 .5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2 .7 2.4 2 .5 2.9 2.7 2.5 2.2 2.9 2 .3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 Company Sanitized. Does not contain TSCA CB! )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 24 Day 25 Day 2 6 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2 .9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2 .9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2 .9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2 .9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 2.4 2.9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2 .5 2.3 2.5 2 .3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2 .9 2 .7 2 .5 2.2 2 .9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 Day 27 2.4 2 .9 2.6 2.2 2.3 2.3 2.3 2.6 2.5 2.5 2.3 2.5 2.3 2.2 2.9 2.5 2.3 3.0 2.4 2.5 2.6 2.4 2.8 2.4 2.6 2.4 2.6 2.9 2.9 2.7 2.4 2.5 2.9 2.7 2.5 2.2 2.9 2.3 2.4 2.4 2.5 2.6 2.2 2.6 2.3 INDIVIDUAL DOSE VOLUMI Day 28 Day 2 9 Day 30 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3 .1 3 .1 2.8 2.5 2.5 3 .0 2.9 2.5 2.3 2 .9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2 .9 2.5 2 .7 2.6 2.8 3 .1 3.1 2.8 2.5 2 .5 3.0 2.9 2.5 2.3 2 .9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3 .1 3 .1 2.8 2.5 2.5 0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2 .8 2.3 2.7 2.5 562 :S (mL) 31 Day 3 2 Day 33 Day 3 4 DuPont-5386 Day 3 5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3 .1 3 .1 2.8 2 .5 2.5 30 2 .9 2.5 2.3 2.9 2 .5 2.5 2.4 2.6 2.8 2.3 2 .7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3.1 3 .1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2.9 2 .5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2.5 3.1 2.5 2.7 2.8 2.5 2.9 2.5 2.7 2.6 2.8 3 .1 3 .1 2.8 2 .5 2.5 3 .0 2.9 2.5 2.3 2.9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.5 2.9 2.7 2.3 2.5 2.3 2.4 2.7 2.8 2.7 2.4 2.6 2.4 2.4 3.0 2.7 2 .5 3 .1 2.5 2.7 2.8 2.5 2.9 2 .5 2.7 2 .6 2.8 3 .1 3 .1 2.8 2.5 2.5 3.0 2.9 2.5 2.3 2 .9 2.5 2.5 2.4 2.6 2.8 2.3 2.7 2.5 2.7 3.2 2.8 2.4 2.6 2.5 2.6 2.7 2 .9 2.8 2.5 2.6 2.6 2.4 3.1 2.8 2.5 3.1 2.6 2.8 3.0 2.6 3.0 2.6 2.9 2.7 2.9 3.2 3.3 3.0 2.6 2.8 3 .1 3.0 2.6 2.4 3 .1 2.6 2.5 2.5 2.7 2.8 2.4 2.8 2.5 Company Sanitized. Does not contain TSC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 3 6 Day 37 Day 3 8 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.7 3.2 2.8 2.4 2.6 2.5 2.6 2.7 2.9 2.8 2.5 2.6 2.6 2.4 3 .1 2.8 2.5 3.1 2 .6 2 .8 3 .0 2.6 3 .0 2.6 2.9 2.7 2.9 3.2 3.3 3.0 2.6 2.8 3 .1 3 .0 2.6 2.4 3 .1 2.6 2.5 2.5 2.7 2 .8 2.4 2.8 2.5 2.7 3.2 2.8 2.4 2.6 2.5 2.6 2.7 2.9 2.8 2.5 2.6 2.6 2.4 3.1 2 .8 2 .5 3 .1 2.6 2.8 3.0 2.6 3 .0 2.6 2.9 2.7 2.9 3.2 3.3 3.0 2.6 2.8 T1 3.0 2.6 2.4 3 .1 2.6 2.5 2.5 2.7 2 .8 2.4 2.8 2.5 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2.1 1.9 INDIVIDUAL DOSE VOLUMES (mL) Day 39 Day 40 Day 4 1 Day 42 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2 .2 2.1 1.9 2 .0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2 .2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2.1 1.8 2 .1 1.9 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2.1 1.9 2.4 1.9 2.1 2.2 2 .0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2 .3 1.9 1.9 1.9 2.0 2 .1 1.8 2.1 1.9 2.0 2.4 2.1 1.8 1.9 1.9 1.9 2.0 2.2 2.1 1.9 2.0 1.9 1.8 2.3 2 .1 1.9 2.4 1.9 2.1 2.2 2.0 2.2 1.9 2.2 2.0 2.2 2.4 2.4 2.3 1.9 2.1 2.3 2.2 2.0 1.8 2.3 1.9 1.9 1.9 2.0 2 .1 1.8 2.1 1.9 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2 .4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 Day 43 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2 .4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2 .3 1.9 2.2 2.0 Day 44 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2 .4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 DuPont-5386 Day 4 5 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2 .5 2.3 2.0 2.1 2 .4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 Company Sanitized. Does not contain TSCA CBI 563 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 46 Day 47 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2. 4 2.3 2.0 1.9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2.0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2 .4 2.3 2.0 1. 9 2.4 2.0 2.0 1.9 2.1 2.3 1.9 2.2 2.0 ay 48 2.1 2.5 2.2 1.9 2.1 2.0 2.0 2.1 2.2 2.1 1.9 2.0 2.1 1.9 2.4 2.2 2.0 2.4 2. 0 2.1 2.3 2.0 2.3 1.9 2.3 2.1 2.2 2.4 2.5 2.3 2.0 2.1 2.4 2.3 2.0 1.9 2.4 2.0 2.0 1. 9 2.1 2.3 1.9 2.2 2.0 INDIVIDUAL DOSE VOLUMES Day 49 Day 50 Day 51 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2. 5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 O1 . *A3 2.4 2. 1 1. 9 2.2 1. 6 2. 0 1.9 2. 2 2.3 1. 9 2. 3 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 ' 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2. 0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2. 0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2. 1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2. 4 2.4 2. 1 1. 9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 564 ) (mL) Day 52 Day 53 Day 54 DuPont-5386 Day 55 2.1 2 .5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 1.7 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 2.1 2.1 2.5 2.5 2.2 2.2 1.9 1.9 2 .0 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.3 2.3 2.2 2.2 2.0 2.0 2.1 2.1 2.2 2.2 1.8 1.8 2.4 2.4 2 .1 2.1 2.0 2.0 2.5 2.5 2.0 2.0 2.2 2.2 2.4 2.4 2.1 2.1 2.4 2.4 2 .1 2.1 2.4 2.4 AK TEST DAY 53 2.2 2.2 2 .5 2.5 2.5 2.5 2.3 2.3 2.0 2.0 2.2 2.2 2.4 2.4 2.4 2.4 2.1 2 . 1 1.9 1.9 2.2 2.2 1.6 1.6 2.0 2 .0 1.9 1.9 2.2 2.2 2.3 2.3 1.9 1.9 2.3 2.3 2.0 2.0 2.1 2.5 2.2 1.9 2.0 2.0 2.0 2.1 2.3 2.2 2.0 2.1 2.2 1.8 2.4 2.1 2.0 2.5 2.0 2.2 2.4 2.1 2.4 2.1 2.4 2.2 2.5 2.5 2.3 2.0 2.2 2.4 2.4 2.1 1.9 2.2 1.6 2.0 1.9 2.2 2.3 1.9 2.3 2.0 Company Sanitized. Does not contain TS C A CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 56 Day 57 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2 .5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2 .2 2.5 2.5 2.2 2.0 2.2 2 .4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2 .0 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2 .2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 Day 58 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2 .4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 INDIVIDUAL DOSE VOLUMES Day 59 Day 60 Day 61 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2 .2 2.0 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2 .5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2 .1 2.3 1.9 2.2 2.0 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2 .5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2.5 2.5 2.2 2.0 2.2 2.4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2.2 2.0 565 (mL) 62 Day 63 Day 64 DuPont-5386 Day 65 2.1 2.5 2.3 1.9 2.2 1.9 2.0 2.1 2.3 2.3 2.0 2.1 2.1 1.3 2.5 2.1 2.0 2.5 2.0 2.2 2.4 2.0 2.2 2.0 2.4 2.2 2 .5 2.5 2.2 2.0 2.2 2 .4 2.3 2.1 1.9 1.8 1.7 1.8 1.9 2.1 2.3 1.9 2 .2 2.0 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2.5 2.5 2 .1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2 .0 1.6 2.2 2 .0 1.9 2.0 2.0 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2 .5 2.1 2.0 2 .4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1 .9 2 .5 2.5 2 .1 1.9 2.3 2.4 2.3 2.1 2.0 2.3 1.9 2.0 1 .6 2.2 2.0 1.9 2.0 2.0 Company Sanitized. Does not contain TSCA CBI 1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 66 Day 67 Female, VIII - 2 5 0 mg / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.3 2 .3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2 .3 2.4 2 .3 2.1 2.0 2.3 1.9 2.0 1.6 2 .2 2.0 1.9 2 .0 2.0 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2 .4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2 .3 2.4 2 .3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 Day 68 2.1 2.3 2.3 1.9 2.1 1.9 2.0 2.0 2.4 2.1 2.0 2.2 2.2 1.8 2.5 2.1 2.0 2.4 2.1 2.2 2.3 2.0 1.8 2.0 2.5 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2 .3 2.1 2.0 2.3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 INDIVIDUAL DOSE VOLUMES Day 69 Day 7 0 Day 71 2.1 2.1 2 . 3 2.2 2.3 2.3 1.9 1.9 2.1 2.2 1 . 9 2.0 2.0 2.1 2.0 2.1 2.4 2.4 FD TEST DAY 69 2.0 1.9 2.2 2.2 2.2 2.2 1.8 1 . 9 2 . 5 2.6 2.1 1 . 7 2.0 1 . 9 2.4 2.4 2.1 2.1 2.2 2.2 2 . 3 2.2 2.0 1.5 1.8 1 . 5 2.0 1.7 2 . 5 2.1 1.9 2.5 2.5 2.1 1.9 2.3 2.4 2.3 2.1 2.0 2 .3 1.9 2.0 1.6 2.2 2.0 1.9 2.0 2.0 2.2 2.4 2.4 2.2 2.0 2 .4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 566 (mL) 72 Day 73 Day 74 DuPont-5386 Day 75 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2 .4 2.5 2.1 2 .0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2 .1 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2.4 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 1.7 1.9 2.4 2.1 2.2 2.2 1.5 1.5 1.7 2.1 2.2 2.4 2.4 2.2 2.0 2r 2.5 2.1 2.0 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 2.2 1.9 2.6 2.0 2.4 1.9 2.0 2.0 2.2 2.0 2.0 2.2 2.1 Company Sanflized. Does no! contain TS C A CB1 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 7 6 Day 7 7 Female, VIII - 2 5 0 mg / kg/ day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.1 2.2 2.3 1.9 2.2 2.0 2.1 2.1 2.4 1.9 2.2 b 2.2 1.9 2.6 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.0 2.4 2.4 1.9 1.9 2.0 2.0 2.0 2 . 1 2.2 2.2 2.0 2 . 1 2.0 1.8 2.2 2 . 3 2.1 1 . 9 Day 7 8 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1 .7 2.2 1.9 1.8 2.1 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 INDIVIDUAL DOSE VOLUMES Day 7 9 Day 80 Day 81 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1 .7 2.2 1.9 1.8 2 .1 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2 .5 1.7 2.2 1 .9 1.8 2.1 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 2.0 2.4 1.9 2.0 2.1 2.2 2.1 1.8 2.3 1.9 2.0 2.4 1.9 2.0 2 .1 2.2 2.1 1.8 2.3 1.9 567 (m L ) 82 Day 83 Day 84 DuPont-5386 Day 8 5 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.0 2.2 2.3 1.9 2.1 2.0 2.0 2.1 2.5 1.7 2.2 1.9 1.8 2.1 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2.0 2.3 2.3 2.0 2.5 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2 .0 2.3 2.3 2.0 2.5 2.0 2.0 2.0 2.0 2 . 4 2 . 4 2.6 2.6 1.9 1.9 2.1 2.1 2.0 2.0 2.2 2.2 2 . 1 2.1 2 . 1 2 . 1 2.2 2.2 2 . 3 2.3 2 . 1 2.1 2 . 3 2.3 1 . 8 1.8 2.0 2.0 2.3 2.3 2.5 2.5 1.9 1.9 2.1 2.1 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 86 Day 87 Female, VIII - 2 5 0 mg/ kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 64344S 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2.5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2.1 Day 88 2.2 2.5 2.4 1.9 2.2 2.1 2.1 2.3 2 .5 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2 .1 2.3 2.3 2 .0 2.5 2.1 INDIVIDUAL DOSE VOLUMES (mL) Day 89 Day 90 Day 91 Day 92 2.2 2.2 2.2 2.2 2 . 5 2 . 5 2.6 2.6 2 . 4 2 . 4 2.2 2.2 1.9 1.9 1.9 1.9 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.1 2.0 2.0 2.3 2.3 2.3 2.3 2 . 5 2 . 5 2.6 2.6 2.0 2.3 2.3 2.0 2.5 2.0 2.6 2.1 2.2 2.1 2.3 2.3 2.0 2.5 2 .1 DuPont-5386 Company Sanitized. Does not contain TSCA CBt H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX C INDIVIDUAL BODY WEIGHTS Company Sanitized. Does not contain TSCA CBI 569 H -24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS EXPLANATORY NOTES DuPont-5386 Critical Dates D ay 7 4 jy|a]e an(j fema]e rats designated for reproduction evaluations were co-housed. Body weights collected during the cohabitation and post-mating periods are reported in the Reproductive Toxicology section. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day o f non-fasted body weight data collection for rats designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day o f non-fasted body weight data collection for rats designated for the 3-month recovery period. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extrem is Company Sanitized. Does not contain TSCA GBI 570  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Male, I -- 0 mg/ kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 278.0 237.5 237.1 262.8 282.1 246.7 235.8 253.6 254.9 254.0 264.6 263.0 244.5 274.2 236.7 246.4 277.8 237.8 207.6 249.3 265.9 243.4 231.5 257.2 253.4 268.6 252.9 244.2 244.9 240.4 251.3 281.7 236.4 245.1 242.2 298.8 243.1 254.1 256.0 227.0 211.2 227.3 220.3 248.7 265.6 Day 7 347.0 296.9 291.5 313.3 345.3 311.5 290.4 323.7 320.6 304.8 321.1 309.7 292.8 336.3 291.4 296.4 341.8 282.6 255.6 300.5 311.9 285.4 279.3 317.0 306.4 335.4 315.7 307.5 295.6 294.8 313.7 352.7 277,9 290.7 300.1 357.6 297.0 311.4 315.6 286.3 261.4 284.3 268.7 291.4 322.1 Day 14 INDIVIDUAL BODY Day 2 1 Day 28 4 0 9 .. 3 3 4 7 ..2 340 .0 3 5 6 .. 7 409 .6 3 6 1 .6 340 .4 383 .9 3 7 7 .6 3 5 0 ..2 3 7 7 ..0 338 .8 3 4 2 ..8 383 .7 3 4 3 ..2 3 4 5 .. 3 3 9 1 .5 3 1 6 .6 2 9 8 .. 9 3 4 7 ..8 3 5 9 .0 3 2 6 ..2 3 3 6 .. 3 3 8 2 .. 3 3 5 1 ..0 3 9 3 ,.3 3 6 4 .. 9 356 .2 3 5 0 .. 4 3 4 8 ..8 3 5 8 ..7 4 2 2 .,7 3 2 1 ,.0 3 3 6 .. 3 3 4 6 ..6 4 2 6 .. 4 3 5 2 .. 7 3 7 2 ..2 3 7 0 .. 4 3 4 3 ..9 3 0 3 ..5 3 3 1 .,6 3 0 5 .7 3 3 4 .6 3 7 0 .. 7 4 5 1 .2 392 .9 381 .3 4 0 9 .0 4 5 9 .2 4 1 3 .8 362 .3 431 .3 422 .4 392 .1 433 .9 381 .3 396 .9 429 .6 384 .1 382 .5 432 .3 352 .1 330 .0 392 .6 402 .9 3 5 9 .2 375 .5 4 2 5 .2 392 .3 4 4 3 .0 4 1 5 .. 5 401 .4 3 8 9 .. 9 3 8 9 .. 5 3 9 6 .. 8 4 6 6 .. 9 3 6 0 ..2 3 6 7 ,. 4 3 8 0 .. 9 4 6 7 ,.6 4 0 4 ..2 4 2 1 .. 4 4 2 6 ..6 3 8 9 ..2 3 3 8 ,, 4 3 6 5 ..0 3 3 4 ..2 3 6 9 .. 7 4 0 7 ..6 497 .6 423 .9 419 .4 447 .6 511 .4 459 .6 3 8 3 .1 468 .9 459 .8 4 2 7 .6 468 .7 396 .6 416 .7 464 .4 414 .4 4 1 2 .6 4 7 3 ..6 371 .3 351 .7 427 .3 434 .6 3 8 9 ..8 4 0 7 .6 4 7 0 .. 9 423 .7 4 8 2 ..2 4 4 5 ..2 4 3 4 .. 9 4 1 7 .. 9 4 1 5 .. 4 4 3 4 ..0 n5 0 2 . 3 9 0 .. 9 3 9 6 ..2 4 0 7 .. 6 5 0 1 ..7 4 3 1 ..4 4 5 2 ..5 4 6 3 .. 9 433 .7 3 7 0 ,, 3 3 9 1 .,1 3 6 6 ..5 3 9 7 .. 1 4 4 7 ..8 571 WEIGHTS (g) Day 3 5 Day 42 Day 49 522.6 455.5 442.7 473.2 53 5 . 6 488.3 409.2 492.0 483.3 444.7 504.2 410.7 440.4 489.6 438.3 445.1 501.1 388.2 373.4 451.9 456.5 420.4 442.7 499.1 445.2 524.1 473.0 464.8 435.3 432.1 464.8 542.2 406.0 413.9 426.8 533.1 456.5 493.0 490.3 471.4 391.1 415.9 396.8 433.7 468.8 5 4 9 .7 483 .5 463 .6 504 .0 5 7 1 .7 514 .2 4 2 6 .9 5 2 0 .1 5 1 2 .9 4 7 1 .0 524 .6 428 .1 4 7 5 .7 5 2 2 .0 4 6 1 .4 4 5 9 .8 5 3 5 .2 410 .2 403 .1 4 8 0 .0 478 .7 434 .9 4 7 2 .2 5 3 1 .5 464 .3 548 .7 493 .2 4 9 7 .1 4 5 5 .0 4 5 4 .4 4 8 6 .7 5 6 5 .8 4 2 9 .5 4 4 0 .8 4 6 0 .0 562 .4 490.6 517 .7 5 1 6 .2 502 .6 418 .0 426.5 4 2 0 .8 4 5 9 .3 4 9 4 .1 571.4 501.2 474.5 517.2 584.1 521.8 430.0 515.9 515.0 492.5 545.3 450.8 489.4 542.2 474.4 481.2 555.9 422.3 412.5 493.7 506.2 455.5 489.0 558.3 488.8 574.8 514.0 525.7 478.1 490.8 502.6 600.1 446.6 474.4 479.3 577.3 510.1 543.6 534.6 531.3 436.4 436.8 437.4 481.9 500.7 DuPont-5386 Day 56 589.6 530.7 492.2 538.3 599.1 549.9 443.8 545.3 539.1 492.2 561.8 452.3 489.5 564.1 491.5 498.7 578.0 437.6 428.9 503.9 529.5 461.7 516.2 583.4 507.0 600.3 539.2 545.5 495.4 528.8 526.7 620.2 463.8 495.9 501.9 592.1 537.3 560.1 569.2 549.6 450.9 416.9 455.2 477.8 521.4 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY EIGHTS (g) Day 63 Day 7 0 Male, I - 0 mg / kg / day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 607.0 554.5 496.9 546.8 622.4 565.9 461.8 568.6 556.6 512.5 558.0 476.2 489.4 582.8 502.5 508.0 597.3 452.8 442.9 525.7 548.2 480.5 536.5 606.7 518.8 619.7 553.9 571.0 514.1 551.5 539.4 646.7 479.4 515.0 523.1 609.6 545.9 573.9 586.1 568.3 466.6 401.9 471.1 495.0 542.5 621.5 570.0 508.2 563.6 632.0 584.2 474.4 583.2 566.5 528.8 583.0 490.3 501.0 600.6 508.3 509.9 620.1 463.8 451.8 533.9 558.2 506.4 557.2 628.5 533 .2 643.8 568.9 589.1 524.1 568.0 564.1 676.8 490.4 530.2 540.0 634.0 570.3 592.2 607.0 5 7 9 .8 480.7 416.8 481.9 504.0 557.6 Day 74 603.0 510.3 512.4 629.2 469.0 458.8 534.3 568.8 504.9 563.1 624.9 531.3 644.0 573.1 586.3 531.5 593.7 562.4 682.3 478.3 Day 77 625.0 582.2 516.7 575.1 640.7 596.8 475.8 600.7 582.7 532.8 575.4 505.9 511.4 505.6 544.4 545.0 641.7 579.1 600.4 620.8 594.0 496.4 378.9 495.6 564.4 Day 84 Day 90 637.6 5 9 4 .8 522.5 584.9 657.5 607.1 485.5 613.5 600.6 551.0 589.5 524.7 511.0 640.6 601.4 524.1 593.0 665.2 602.7 492.0 628.9 610.2 546.8 573.8 530.6 522.9 Day 9 8 560.0 609.2 547.9 523.9 507.0 550.0 559.9 643.8 599.8 598.8 629.3 607.2 504.3 402.4 515.2 590.1 5 1 0 .. 5 5 5 7 ..8 5 7 2 ..6 6 6 1 ..1 6 0 5 ,. 5 6 0 8 ..8 6 3 4 ..6 6 1 6 ..0 5 0 8 ..2 4 1 3 .. 3 5 2 2 .. 0 595 .4 5 2 5 ..6 5 7 7 ..0 5 7 7 .. 3 6 8 5 ..8 6 3 7 ..0 6 3 2 ..1 6 4 9 .. 7 6 4 0 .. 5 5 2 2 .. 5 4 4 8 .. 1 5 3 6 .. 6 Day 1 0 5 576.6 631.3 533.8 528.2 5 2 6 .. 7 5 9 4 ..0 5 9 1 ..4 6 9 6 ..6 6 4 5 .3 6 5 4 ..2 6 6 3 ..2 6 5 7 .. 4 532 .4 417 .3 544 .3 DuPont-5386 Day 112 587.3 648.2 546.4 533.8 5 3 3 .. 0 6 0 2 .,7 6 1 8 ..6 7 0 0 .. 1 6 5 4 .. 4 6 6 4 .. 3 6 7 3 .. 9 6 6 7 .. 9 544 .0 448 .3 554 .5 C o m p a n y S a n itize d . Does not contain TSCA CBI 572 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) ay 1 1 9 Day 1 2 6 Male, I - 0 m g / kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 596.0 601.4 547.3 5 3 3 .8 536.4 609.3 621.1 702.0 661.4 678.7 673.0 671.7 539.2 434.2 578.7 622.5 548.2 538.2 555.3 Day 133 600.9 636.3 556.5 548.9 549.0 Day 1 4 0 Day 1 4 7 600.0 657.5 578.8 553.5 610.7 672.6 593.0 569.2 5 6 9 . 0 57 3 . 0 546.0 Day 154 616.7 678.3 601.7 579.6 558.4 Day 1 6 1 620.1 693.2 606.0 579.4 573.3 Day 1 6 8 618.8 697.8 621.4 574.1 583.2 1 DuPont-5386 Day 1 7 5 632.6 720.7 644.4 585.5 594.1 Company S a n itize d . Does not contain TSCA CBI 573 1) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 1 8 1 Male, I - 0 mg/ kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 606.2 687.8 617.5 576.9 557.8 574 ) DuPont-5386 Company Sanitized. Does not contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ! INDIVIDUAL BODY Day 0 Day 7 Male, III - 2 5 mg / kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 239.1 214.9 227.0 246.5 276.0 259.3 273.4 254.7 240.6 261.6 229.4 259.8 216.0 272.6 245.5 205.8 263.6 261.9 258.0 192.6 251.8 261.5 261.6 231.5 242.3 242.7 273 .5 256.8 241.7 252.6 255.0 241.1 262.6 269.4 228.7 302.6 272.0 277.8 300.7 346.4 326.3 332.3 302.4 302.8 313.9 281.6 316.0 259.7 319.4 299.3 255.4 331.6 310.9 322.2 243.1 309.3 325.0 320.0 278.3 292.7 305.5 340.7 318.7 297.3 315.8 312.5 287.6 322.4 327.0 282.5 Day 14 Day 2 1 Day 28 3 5 0 .. 3 3 2 3 ..6 3 2 5 .. 4 3 4 5 .. 8 4 0 7 .. 7 3 8 6 .. 4 390 .6 3 5 9 ..8 3 6 2 .. 0 3 7 0 .. 9 3 2 7 ..0 3 6 4 ..2 301 .6 3 6 8 ..2 352 .5 302 .0 3 9 6 .0 350 .4 3 7 4 .. 9 2 9 4 ..6 3 6 5 .. 3 3 7 4 .. 6 3 8 4 .2 3 3 7 .. 7 3 4 7 .. 4 3 5 7 .. 8 4 0 2 .. 4 3 7 9 .. 9 3 4 0 .. 9 3 7 7 .2 3 5 5 ..7 3 2 9 .. 5 3 6 8 .. 7 383 .1 323 .1 3 8 4 .. 9 3 5 7 .. 9 3 5 4 .. 9 3 8 6 .2 450 .9 4 2 4 .. 1 4 2 9 .0 3 7 7 .. 9 3 9 5 .. 4 4 1 0 .. 4 3 5 6 .. 7 4 1 3 .. 5 331 .0 4 0 1 .. 3 391 .4 337 .8 4 3 8 .. 5 3 8 0 .0 412 .6 3 2 9 ..2 4 1 5 ..2 415 .9 421 .9 3 7 2 .. 1 375 .3 402 .5 447 .9 4 1 8 .. 5 3 6 9 .. 5 4 2 0 ..1 3 9 1 .. 5 3 5 8 .. 1 4 0 4 .. 3 416 .9 3 5 6 .. 1 4 2 3 ..0 3 9 7 .. 1 3 9 4 ..8 424 .0 4 9 3 .. 7 4 6 4 .. 8 4 6 5 ..1 4 1 1 ..6 4 3 7 .. 0 4 4 3 .. 9 3 8 4 .. 8 4 4 9 .. 6 365 .6 4 2 1 ..8 422 .9 369 .6 4 7 9 .. 3 410 ,3 4 4 9 .. 1 3 6 6 .. 6 4 5 5 .. 3 460 .9 4 4 9 .. 8 4 1 1 .. 4 4 1 6 .. 0 4 3 9 .. 7 4 8 9 .6 4 5 9 .. 9 384 .5 4 5 1 ..4 4 1 8 .2 3 8 1 .. 9 4 4 4 ..8 4 5 6 .. 9 3 8 8 .. 9 575 ) WEIGHTS (g) Day 3 5 Day 4 2 Day 4 9 DuPont-5386 Day 56 4 7 0 ,.2 4 3 3 ..2 4 1 2 .. 3 4 5 7 ,. 9 5 4 0 ,.2 4 9 8 .. 7 5 0 4 .. 4 4 3 3 .. 6 4 7 8 .. 1 4 6 2 ..1 4 1 1 ..0 4 7 5 .. 5 3 8 8 .. 1 4 5 6 ..8 4 6 1 .. 6 3 9 7 .. 0 5 0 5 ..2 433 .9 4 7 8 ..6 3 8 5 .. 9 4 8 7 .. 5 4 8 7 .. 4 4 8 7 ,.0 4 4 3 .. 3 4 5 3 .. 5 4 7 4 .. 8 5 2 2 .. 3 4 9 0 .. 4 3 9 6 ,.2 4 8 7 ..2 4 4 0 ..8 4 0 9 .. 5 4 8 0 .. 5 4 8 9 .. 3 4 1 6 ..2 4 7 7 ,.0 462 .5 4 3 4 .. 7 483 .0 5 6 0 .. 1 5 2 0 .. 4 5 2 7 .8 4 4 6 .. 3 5 0 9 .. 5 4 7 9 ..6 4 2 8 .. 5 4 9 4 .6 407 .9 4 6 8 .8 4 7 9 .. 7 4 1 2 .. 1 5 2 2 .. 5 4 4 4 .8 4 9 8 .. 5 4 0 9 ..2 5 1 6 ..2 5 0 5 ..8 5 0 3 .. 9 4 5 7 .. 3 4 6 0 .. 1 4 9 2 .. 0 5 3 6 ..6 5 1 3 .. 4 4 1 3 .. 5 5 0 0 ,. 3 4 6 2 .,4 4 2 2 .. 4 5 0 5 .. 7 5 1 1 ..2 4 3 0 ,. 1 4 9 0 .. 5 4 7 2 .6 444 .7 4 8 9 .0 5 7 0 .. 3 5 2 9 ..1 5 3 6 .6 445 .4 5 1 8 .. 4 4 8 0 .8 446 .9 5 0 2 ..0 407 .3 487 .3 4 9 9 .0 4 2 2 .8 5 4 7 .8 461 .7 5 1 3 .0 4 2 4 .6 5 3 5 .8 510 .3 5 2 4 .0 4 8 6 .6 470 .1 5 1 3 .. 4 5 6 3 .. 7 5 3 1 .. 7 4 2 0 ..6 5 0 8 ..6 4 7 5 .0 428 .4 5 3 0 ..2 5 3 2 ..8 4 5 6 ..4 5 1 1 ..6 5 0 2 ..0 4 5 9 ..8 5 0 2 ..5 6 0 1 ..8 5 5 3 ..1 5 6 4 ..2 4 5 7 ..0 5 3 4 ..6 4 9 7 .. 9 4 4 4 ..1 5 2 2 .. 3 4 2 0 .. 1 4 9 6 .. 7 5 2 2 .. 4 4 3 6 ..0 5 8 2 .. 7 4 7 3 .. 4 5 2 3 ,, 3 4 3 8 .. 4 5 5 3 .. 3 5 3 1 .. 7 5 4 6 ..0 5 0 6 .. 9 4 9 2 .. 3 5 3 2 .. 3 582 .2 5 5 1 .. 9 4 3 6 .. 4 5 2 0 ..8 4 8 8 .. 9 3 9 2 .. 3 5 4 7 ..5 5 4 9 ..3 4 7 0 ..9 Company Sanitized. Does no! contain TSCA CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 63 Day 7 0 Male, III - 2b mg/ kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 524.4 513.5 487.6 520.8 625.8 564.5 589.3 468.4 554.5 495.5 448.4 535.0 426.4 512.2 540.9 448.0 602.5 489.3 546.0 456.7 582.8 548.6 569.2 526.3 511.4 549.2 589.5 568.2 433.2 537.4 502.2 440.6 565.1 572.6 479.7 528.6 529.0 504.8 534.8 646.0 588.3 603.8 482.3 553.3 514.6 459.8 554.8 438.1 530.6 553.4 466.8 614.3 4 9 5 .6 564.5 474.3 600.0 557.6 591.6 552.5 525.4 562.8 605.3 591.3 441.2 553.7 516.6 460.8 576.7 586.0 493.3 Day 74 464.4 627.9 498.8 562.9 469.4 604.5 574.2 594.0 559.7 536.0 566.0 624.1 593.3 461.8 555.7 523.6 480.3 585.6 587.9 495.4 Day 77 544.9 544.5 520.7 537.5 663.3 600.9 622.6 488.9 557.5 525.3 466.6 553.1 444.8 537.2 547.1 Day 84 Day 90 540.5 561.0 538.4 536.4 685.3 625.9 635.0 4 9 9 .6 576.5 541.1 471.6 565.6 461.3 543.1 553.5 514.0 573.3 549.4 541.3 699.3 630.5 651.5 507.7 573.7 543.5 483.2 567.1 464.0 549.6 562.8 Day 98 489.9 581.8 482.5 564.1 579.5 Day 1 0 5 500.1 597.1 485.5 578.7 587.6 ) DuPont-5386 Day 1 1 2 508.4 580.5 490.4 597.1 607.7 Company Sanitized. Does not contain TSC A CBI 576 1 f ) ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________________________________________ DuPont-5386 INDIVIDUAL BODY WEIGHTS (g) Day 1 1 9 Day 1 2 6 Male, III - 25 mg/ kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 509.3 565.5 471.9 609.8 606.0 509.9 572.8 479.5 590.0 574.3 Day 1 3 3 521.6 595.9 503.7 581.0 603.1 Day 1 4 0 518.4 605.8 503.3 604.0 617.6 Day 1 4 7 525.8 623.0 514.4 617.7 628.8 Day 1 5 4 532.0 620.3 511.9 630.9 637.5 Day 1 6 1 534.7 626.3 517.1 638.6 644.0 Day 1 6 8 541.9 635.2 529.6 653.5 650.3 Day 17 5 550.2 640.2 531.8 672.8 653.7 Company Saniffcetf. Does not contain TSCA CBl 577 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g Day 1 8 1 Male, III - 2 5 mg/ kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 523.6 618.7 514.8 644.7 620.2 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY Day 0 Day 7 Male, V - 100 mg/ kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 229.7 230.7 236.3 260.0 280.3 260.0 263.1 271.8 236.3 253.3 231.9 267.5 210.0 280.8 239.5 206.6 248.0 275.5 244.2 241.3 248.4 271.2 249.9 231.1 255.1 244.3 256.6 241.6 257.0 262.7 250.5 243.9 266.4 245.0 273.7 275.3 288.5 297.5 321.5 353.1 321.8 328.2 323.6 302.8 302.9 277.3 306.7 252.5 333.0 286.7 266.7 310.5 327.6 303.7 311.3 310.4 337.7 303.2 276.2 311.6 307.8 314.2 295.0 307.2 330.3 325.4 297.9 330.2 302.6 333.5 Day 14 Day 21 Day 28 3 1 1 .. 4 347 .9 3 5 5 ..8 373 .2 4 1 3 ..5 3 7 0 ..2 3 7 1 ., 5 3 6 5 ..2 3 4 7 ..1 3 4 1 ..1 3 2 6 ..1 3 5 6 ..6 2 8 6 ..5 3 7 7 .. 1 3 2 4 .. 4 3 1 5 ..4 3 7 2 ,.2 3 7 3 .. 7 3 4 7 ..0 3 7 3 .. 9 3 7 0 .. 9 3 9 8 .. 3 3 5 6 ..6 3 1 3 ..6 3 6 1 .. 5 3 6 1 ..8 372 .5 3 4 7 ..0 3 4 9 .. 9 3 8 0 .. 1 3 8 2 ..1 3 4 0 .. 4 3 8 1 .. 4 3 4 7 .. 3 3 8 4 ,.1 3 5 2 .. 4 3 8 6 ..2 3 8 5 .. 5 4 2 8 .. 9 4 4 9 .. 9 4 2 3 ,. 3 4 1 0 .. 1 4 0 7 .2 3 8 7 .. 3 3 7 4 .. 5 3 6 7 .. 6 3 9 4 ..2 327 .5 409 .5 366 .0 3 5 6 ..1 421 .5 420 .0 383 .5 422 .1 418 .1 450 .8 392 .8 3 4 8 .. 4 4 0 3 ..0 402 .1 420 .5 3 8 7 .2 396 .5 411 .4 426 .5 387 .0 428 .0 390 .3 422 .4 3 8 5 .. 1 4 2 0 ..0 4 1 8 .. 7 4 6 2 ..6 4 7 7 ..0 4 5 3 ..1 4 3 1 ..8 4 4 7 .. 9 4 0 8 .. 9 4 0 4 .. 5 4 0 0 ..8 4 3 1 .. 5 361 . 4 4 3 7 .. 5 3 8 4 .. 6 3 9 4 .. 4 463 .8 4 5 2 ..0 4 0 3 .. 6 466 .4 4 5 1 .2 488 .1 426 .7 3 7 8 .. 3 4 3 9 .. 3 4 4 2 .. 9 4 6 0 .. 7 421 .9 411 .0 448 .5 4 7 1 .1 4 1 5 ..0 4 6 7 .. 0 411 .9 450 .4 579 ) WEIGHTS (g) Day 3 5 Day 42 Day 4 9 DuPont-5386 Day 56 3 9 5 .. 5 4 4 7 .. 4 4 4 4 ..2 4 9 4 .. 4 4 9 6 ..7 4 8 0 .. 4 4 5 2 ..1 4 6 9 ..6 4 3 6 .,2 4 2 0 ..0 4 2 0 ..2 4 6 6 ..1 3 8 9 .. 5 4 6 2 ..1 397 .7 4 2 0 ..1 4 9 6 .. 5 479 .7 4 1 8 .. 1 4 8 2 .0 483 .7 5 2 2 .6 447 .3 3 9 1 .. 4 4 6 6 .. 3 4 6 6 .. 1 480 .4 4 5 3 .2 434 .9 469 .4 499 .8 437 .8 492 .5 433 .8 4 8 1 .2 4 0 8 .. 9 4 6 9 .2 4 6 6 .3 5 1 2 .8 5 2 6 .. 4 5 0 3 .,8 4 7 7 ..8 4 8 8 ..0 4 5 1 ..8 4 3 6 .. 4 4 3 9 ..8 4 8 0 .. 7 4 1 1 .. 9 4 9 0 ..6 4 1 8 ..0 4 4 2 .. 7 5 1 3 ..6 4 9 5 ..2 4 3 3 ..0 488 .3 5 0 1 .. 5 545 .1 4 6 9 .6 4 0 3 .. 4 4 8 4 .. 5 4 9 6 ..6 5 1 3 .. 1 4 7 8 .. 9 460 .5 500 .7 5 1 9 .. 7 4 5 9 ..2 5 1 8 .. 3 4 5 8 .8 502 1 4 2 2 ..1 4 8 1 .1 4 7 5 .2 5 2 3 ..8 4 8 0 .. 4 5 0 9 ..0 4 9 2 ,.6 5 0 0 ,.2 4 5 9 .. 5 4 4 6 ..2 4 4 9 ,. 4 4 9 8 .. 9 4 3 5 ,. 9 5 1 8 .. 5 443 .3 466 .4 5 2 8 .. 5 512 .3 4 3 9 ..0 507 .9 5 3 3 .6 565 .4 490 .9 418 .6 5 0 4 .1 5 ] 1 .8 5 3 9 .6 503 .9 4 8 8 .2 531 .6 546 .4 4 8 0 .6 549 .9 481 .7 5 2 1 .2 4 4 0 ..1 4 9 6 ..8 4 8 1 .. 7 5 3 8 .3 5 0 4 ..2 5 3 2 ..2 5 0 5 .,1 5 2 1 ..0 4 7 4 .. 9 4 5 0 ..1 4 4 7 ..0 5 1 5 ,,8 4 4 7 .. 5 5 3 3 .. 3 4 4 0 .. 1 485 .4 5 4 8 ,. 9 5 2 7 ..2 4 6 3 ..6 5 1 9 .. 5 5 3 5 .. 7 578 .5 494 .6 4 3 7 .. 0 5 2 1 .. 7 5 2 9 .. 4 5 5 7 .6 522 .3 511 .5 548 .9 5 6 6 .2 4 9 4 ..2 5 7 4 .. 7 500 .5 538 .7 company Sanitized, Does not contain TSCA C B I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 63 Day 7 0 Male, V -- 100 mg/ kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 458.6 520.0 494.5 549.9 527.4 526.3 516.8 541.3 485.0 467.1 448.5 532.6 471.8 541.8 460.9 502.2 567.2 544.7 486.8 529.0 545.3 597.9 520.1 459.4 540.3 546.4 583.6 555.1 528.7 561.0 581.6 509.0 598.7 519.4 567.0 472.1 532.4 508.7 563.5 545.3 454.6 531.0 560.5 496.1 471.5 469.4 536.5 484.2 570.7 473.7 511.2 582.9 573.3 502.0 544.7 568.2 607.6 514.6 469.9 559.1 564.3 601.7 575.1 547.4 577.4 602.5 516.2 615.1 529.6 562.5 Day 74 514.2 588.1 573.8 513.4 551.5 570.1 605.8 508.5 468.8 561.0 570.6 612.3 576.5 547.3 589.1 602.9 514.9 610.9 529.4 561.8 Day 7 7 Day 84 Day 90 470.0 543.5 511.3 570.8 555.9 397.4 538.2 562.2 501.5 480.8 475.8 544.8 490.8 590.3 472.9 485.1 548.3 519.3 575.6 562.6 \K TEST DAY 476.3 542.8 513.3 491.0 486.1 534.0 501.8 599.8 489.0 77 492.6 554.5 526.4 593.3 572.4 529.3 541.2 520.6 490.7 488.4 532.7 498.4 599.1 496.3 Day 98 506.9 545.3 496.8 588.8 501.8 Day 1 0 5 514.8 427.7 509.2 613.1 502.8 DuPont-5386 Day 112 515.4 463.3 513.5 63 8 . 1 496.8 ,`ompany Sanitized. Does not contain TS C A C B t H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 1 1 9 Day 1 2 6 Male, V - 1 0 0 mg/ kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 497.5 515.1 503.2 636.4 506.4 517.7 539.7 461.5 631.3 505.3 Day 1 3 3 510.3 555.0 504.4 635.1 520.8 Day 1 4 0 523.2 574.0 527.3 657.0 521.1 ly 147 Day 154 535.0 587.4 544.4 676.0 532.0 548.3 609.0 556.8 688.4 533.0 Day 161 555.9 611.1 557.1 706.6 542.4 Day 168 569.3 620.0 563.7 738.4 548.5 DuPont-5386 Day 175 574.5 626.5 579.6 7 57.2 555.4 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 1 8 1 Male, V - 1 0 0 mg/ kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 555.3 608.8 558.5 729.9 534.3 DuPont-5386 Company Sanitized. Does not contain TSCA CBl 582 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY Day 0 Day 7 Male, VII - 2 5 0 mg / kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 238.2 224.4 230.1 236.0 267.2 265.5 251.8 266.4 242.1 275.9 238.2 261.9 226.2 286.4 250.2 211.8 263.8 264.8 249.1 255.7 285.9 256.2 249.3 235.1 239.6 237.1 261.3 260.1 244.4 273.4 2 52 .4 277.8 246.7 250.3 263.9 274.6 234.0 236.7 249.0 246.7 239.2 248.3 234.2 281,8 239.4 296.9 287.0 281.8 289.8 326.9 335.0 325.1 334.3 294.4 348.3 294.3 313.8 274.0 353.0 303.9 268.2 334.8 337.4 307.1 319.2 367.2 310.3 307.8 293.7 300.4 298.9 322.5 321.7 297.8 335.9 315 5 349.2 303.2 302.3 326.3 340.6 301.5 296.6 311.4 312.8 299.5 312.4 284.8 343.2 299.2 Day 14 336.6 332.4 320.5 330.8 372.9 383.2 379.6 379.8 344.4 394.7 342.9 356.5 306.3 412.6 340.2 307.3 394.0 388.3 355.1 362.8 419.8 350.0 350.4 337.6 350.8 348.7 374.0 366.1 331.5 381.9 366.7 410.4 353.5 350.8 371.9 391.8 352.8 350.5 360.1 362.7 354.3 367.0 326.3 384.9 342.7 Day 21 382.6 372.1 352.4 372.3 417.5 433.3 424.0 429.6 392.9 449.4 371.5 400.3 338.0 464.9 381.6 350.7 452.4 435.2 390.6 418.9 472.0 392.0 386.0 378.3 391.3 390.7 419.7 413.4 375.7 423.0 417.0 472.5 393.9 393.4 407.9 438.5 401.4 398.2 401.7 410.4 399.1 412.8 364.6 427.2 387.8 Day 28 410.4 404.1 379.5 402.8 448.1 461.1 452.9 462.1 427.9 485.4 398.4 438.8 293.0 504.9 406.6 380.3 481.7 463.2 421.9 453.0 504.2 419.9 418.6 408.7 418.1 422.9 459.2 444.6 401.0 443.7 4 5 3 .8 510.6 423.4 423.0 433.1 469.3 431.7 429.9 432.6 445.4 432.0 451.1 396.0 458.1 422.6 583 WEIGHTS (g) Day 3 5 Day 4 2 Day 49 DuPont-5386 Day 56 432 .4 433 .9 3 9 5 ..6 4 2 8 ..6 4 6 8 .,1 4 7 9 .. 9 4 7 8 .. 7 4 9 4 ..2 4 5 1 .. 3 5 1 9 .. 7 4 1 9 .. 7 4 6 6 .. 9 3 1 8 .. 3 5 3 1 .. 9 4 3 2 .8 404 .3 5 0 9 .. 5 494 .3 462 .4 4 8 6 .. 5 5 2 9 .. 5 4 4 2 ..6 440 .5 4 2 7 .. 5 4 4 1 .2 4 5 3 .2 491 .9 471 .4 4 2 2 .8 4 6 0 .. 0 481 .1 5 3 6 .8 445 .5 446 .3 454 .4 4 9 5 .8 4 5 6 .2 4 5 5 .8 447 .4 4 5 3 ,.8 460 .5 482 .7 4 1 5 .6 494 .4 451 .1 448 .2 4 5 4 .7 4 1 2 .. 4 4 4 7 ..8 4 7 8 ..6 5 0 1 ..6 4 9 2 .. 4 5 1 5 .. 9 4 7 3 .. 5 5 3 1 ..7 4 2 9 ..6 4 9 7 .. 5 3 5 7 ,. 7 5 5 1 .. 7 4 5 2 ..6 4 2 0 .2 5 3 8 .. 4 512 .5 491 .5 4 9 9 ..0 5 4 6 .. 7 4 6 0 .. 5 4 5 3 ,.6 4 5 5 .. 7 4 6 5 .2 472 .4 514 .7 4 9 0 .6 435 .8 4 7 6 ..8 497 .0 5 5 7 .. 7 463 .3 464 .2 4 7 5 .2 507 .4 391 .0 471 .5 460 .5 4 6 6 .. 9 4 7 5 .. 4 504 .1 4 2 6 .2 505 .0 459 .7 463 .5 440 .2 4 1 0 .4 4 4 7 .. 5 4 7 3 .. 4 5 0 3 ., 5 4 9 6 ..8 5 0 2 .. 7 4 7 1 ..6 5 3 4 .. 4 4 2 0 ,. 4 5 0 9 ,. 1 3 5 4 ..8 5 7 0 ..6 4 5 6 ..0 426 .6 5 4 3 .2 5 3 3 .8 4 9 8 .0 5 1 1 .. 7 558 .3 457 .8 460 .7 449 .7 4 7 7 .0 484 .5 5 2 3 .2 4 9 5 .6 450 .4 4 8 8 .8 505 .9 586 .7 474 .5 473 .1 4 7 7 .6 518 .9 4 3 9 .6 485 .6 471 .7 4 8 1 .2 458 .4 519 .9 437 .9 5 2 5 .8 483 .8 4 8 0 .8 4 5 4 .9 4 2 6 .4 4 5 1 .1 493 .0 4 1 7 .0 5 2 3 .. 4 5 1 0 .. 7 4 6 1 .. 7 5 4 5 ..2 4 3 0 .. 5 5 1 5 .. 7 3 6 9 ..1 5 7 0 ..5 3 9 1 ..6 3 8 3 .. 9 5 4 4 .. 4 5 4 9 .. 3 513 .0 5 1 7 ..0 4 9 9 .. 3 4 7 0 ,, 7 4 6 8 .. 7 4 7 8 .. 5 4 9 0 .. 5 4 9 5 .. 0 5 2 7 .. 8 5 1 0 ,. 3 4 6 4 .. 1 4 9 5 ..0 5 1 0 ..0 5 8 3 .. 4 4 8 1 .. 8 4 7 9 .. 3 4 8 1 .. 7 5 3 4 ..8 4 5 6 ..7 4 9 6 .6 462 .3 5 0 5 .. 3 4 5 8 ..2 5 2 5 .. 5 4 4 8 .. 8 5 2 5 .. 9 496 .5 Company Sanitized. Does not contain TSCACBf )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS {g ) Day 63 Day 7 0 Maie, VII - 2b0 m g / kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 487.4 4.7 7 . 1 445.3 4 7 3 .8 497.7 470.9 532.0 532.0 469.7 568.0 423.1 514.8 368.7 587.5 389.3 398.5 548.8 558.9 514.5 482.2 531.7 426.0 457.2 444.8 489.0 501.4 507.5 494.7 4 7 3 .8 508.7 519.4 579.0 458.2 477.3 497.9 539.4 479.0 505.6 437.7 481.6 434.2 534.5 431.8 489.4 508.1 501.3 369.1 446.4 489.8 426.3 485.5 537.0 532.0 495.7 578.6 394.7 523.6 369.4 595.6 3 3 7 .8 423.4 453.0 573.0 457.9 478.4 487.8 396.8 439.9 474.1 480.2 502.0 518.2 520.8 480.4 511.1 530.9 499.3 375.0 393.0 511.2 427.7 480.1 504.8 444.3 500.0 460.8 537.4 427.7 437.7 510.8 Day 74 Day 77 373.5 513.8 561.0 491.4 462.4 AK TEST DAY 70 430.7 434.7 488.8 438.6 454.9 529.3 515.9 472.5 512.5 487.3 559.5 414.4 459.2 511.7 502.9 451.7 453.5 463.5 487.2 506.9 492.7 549.4 453.6 580.3 440.3 527.4 351.7 595.9 420.7 509.0 515.4 416.0 502.3 455.7 485.3 393.2 525.3 396.1 504.5 Day 84 518.8 502.2 458.6 497.2 515.2 537.3 530.1 564.4 498.0 590.3 443.4 547.2 386.9 624.5 432.9 Day 90 532.9 530.3 463.6 501.1 533.1 562.2 544.4 576.8 509.9 596.3 471.1 543.9 394.5 628.3 456.8 528.1 563.5 473.8 521.7 470.0 518.5 481.1 549.2 4 5 4 .6 512.2 545.3 581.2 498.5 528.7 476.1 543.5 508.2 564.1 458.5 503.6 Day 98 482.4 549.7 408.2 643.9 454.9 555.1 593.9 512.8 538.2 483.6 545.0 536.6 576.8 476.0 536.2 Day 1 0 5 497.2 543.2 407.9 661.0 457.9 568.1 610.2 532.9 557.9 485.4 553.3 532.6 580.3 477.6 548.4 DuPont-5386 Day 112 471.8 548.0 413.9 678.4 454.9 570.1 618.5 537.0 568.4 498.2 578.2 544.9 593.2 482.1 550.9 Zowpany Sanitized. Does not contain TSCACBf 584 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 1 1 9 Day 12 6 Male, VII - 2 5 0 mg/ kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 483.5 554.9 411.6 694.2 466.1 576.3 627.0 539.7 575.0 515.5 570.9 560.3 591.6 495.6 566.1 493.1 550.8 421.1 708.0 477.0 Day 13 3 511.7 574.8 429.9 726.3 487.8 Day 140 526.6 582.0 446.5 728.7 499.4 Day 1 4 7 547.4 609.1 454.5 743.7 513.4 Day 1 5 4 560.7 610.6 460.9 750.7 528.9 Day 1 6 1 567.8 622.9 470.7 756.5 551.5 585 DuPont-5386 Day 1 6 8 Day 1 7 5 585.2 637.2 479.4 782.9 554.0 596.1 643.6 484.4 782.6 546.5 Company Sanilfeed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) Day 1 8 1 Male, VII - 2 5 0 mg/ kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 575.2 619.1 457.7 770.5 522.5 586 DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY Day 0 Day 7 Female, II - 0 mg/ kg/day 643477 643374 643406 643486 643351 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 173.9 184.0 161.9 181.9 189.3 224.2 174.1 182.1 184.2 162.0 178.9 167.2 213.8 177.2 190.9 185.0 170.9 212. 5 188.6 197.8 197.9 186.0 202.8 185.6 184.2 207.1 209.9 209.5 176.5 191.1 221.0 194.8 191.3 177.5 183.8 214.9 202.5 209.3 183.1 205.4 203.0 172.6 201.4 191.5 197.9 202.3 212.6 185.0 185.2 214.0 243.9 188.9 201.4 208.4 173.4 193.2 189.9 219.3 194.5 215.3 214.3 185.4 228.4 226.2 226.6 228.3 206.9 234.0 225.3 203.9 234.3 243.5 246.8 183.6 213.2 241.8 228.2 224.8 201.2 216.5 240.1 231.0 229.9 207.8 243.7 223.1 188.2 216.4 211.0 217.5 Day 14 213.3 230.6 207.7 190.6 222.4 265.8 209.5 225.0 236.4 191.7 221.3 204.0 243.7 210.7 236.1 229.7 210.4 248.5 238.0 239.1 241.9 219.7 256.4 249.2 215.5 250.7 263.2 261.6 204.5 223.4 272.9 244.9 240.8 209.6 224.3 265.7 243.4 229.8 231.4 256.1 252.2 206.3 247.9 236.9 237.7 Day 21 Day 28 236.3 240.1 216.1 208.4 258.1 268.1 229.0 243.1 253.7 210.1 233.9 220. 5 266.7 216.6 249.1 253.6 228.8 257.1 251.0 253.8 268.5 229.4 261.7 262.7 234.4 279.8 286.5 279.7 205.7 240.7 286.9 257.4 257.0 227.7 239.7 283.8 266.5 245.3 259.8 273.9 269.6 220.9 265.0 254.7 264.4 239.5 246.9 226.2 208.0 272.6 292.2 243.0 258.1 258.8 217.9 239.9 219.5 278.2 233.0 261.6 262.2 241.5 273.3 266.2 270.1 273.2 243.2 288.6 270.7 238.9 285.6 305.0 291.4 227.2 255.4 300.7 286.9 269.9 236.6 251.7 304.6 278.5 270.4 273.1 301.4 279.1 239.0 290.6 274.2 273.5 587 WEIGHTS (g) Day 3 5 Day 42 Day 4 9 DuPont-5386 Day 56 2 6 4 .. 5 2 5 6 .. 5 2 4 3 ..6 2 2 1 .,8 2 8 4 ..2 3 0 5 ., 4 2 6 2 ..2 2 7 1 .. 7 2 7 6 .. 8 2 2 6 ..2 2 4 8 .3 2 3 8 .,0 2 7 4 ..2 2 3 6 ., 7 2 7 9 ..6 2 8 0 ..2 2 6 2 ..6 2 8 5 .. 3 2 7 7 .,0 2 8 6 ..8 2 9 3 ,. 7 2 5 3 .. 5 3 0 2 ,.6 2 7 7 ..2 2 5 3 .. 9 319 .5 3 2 4 ..2 3 0 7 .. 3 2 3 4 .,0 2 5 7 ..2 3 2 1 ..8 3 0 0 .. 3 2 8 9 ,. 4 2 4 3 ,. 3 2 5 4 ..8 3 1 8 .. 5 2 9 2 ., 7 2 8 1 .. 9 2 9 1 .. 4 2 9 6 ..6 2 9 0 ..8 254 .1 2 9 8 .. 5 2 9 4 .,2 2 8 5 .. 9 2 7 1 ..1 2 6 8 .. 4 2 4 5 ..8 2 2 6 ..2 2 9 3 ..1 3 0 9 .. 4 2 6 0 .. 7 2 7 4 ..1 2 8 2 .. 4 2 4 3 ,.8 2 5 1 .. 4 2 4 4 .. 3 2 8 7 ..1 2 3 9 .. 9 2 7 1 .. 6 2 8 4 ..2 2 6 3 ..2 3 0 3 .. 4 2 7 7 .. 3 2 8 4 .. 5 3 0 3 .. 7 2 6 2 .0 2 9 7 ..6 287 .7 2 6 6 .. 3 3 3 1 .2 3 3 6 .. 5 3 1 9 ,6 2 3 9 ..8 2 6 4 ,. 7 3 2 2 ..6 3 0 9 .. 3 299 ,1 n2 4 8 . 2 6 5 ..8 3 4 0 .. 3 2 9 8 .. 9 282 .5 297 .1 3 0 7 .6 3 0 7 .. 7 2 6 1 .8 3 1 1 .8 2 9 3 .1 2 9 9 .. 4 2 7 2 .. 7 2 7 9 .. 9 2 5 5 ..2 2 3 7 ,.6 3 1 8 ..8 3 0 8 .. 3 2 7 2 .0 2 7 6 .8 2 8 5 .2 259 .4 2 6 7 .. 0 2 5 9 ,. 7 2 9 7 .. 7 2 4 9 ..6 2 8 4 .. 3 295 .4 2 7 4 .. 4 3 1 6 .6 291 .1 289 .9 3 0 9 .. 9 274 .8 3 1 5 ..1 301 .9 270 .9 347 .8 349 .3 3 3 0 .. 3 2 4 4 .. 3 2 7 2 .6 3 4 4 .. 7 319 .4 3 0 7 .. 8 2 6 1 .0 269 .7 3 5 4 .6 307 .3 280 .5 301 .9 315 .4 3 1 5 .2 266 .3 318 .1 3 0 7 .0 309 .7 2 7 0 ..8 2 8 2 ..6 2 5 9 .,8 2 5 6 ..2 3 3 1 ..0 3 2 7 ,. 7 2 8 8 ..1 2 9 5 .. 9 2 9 2 ..0 2 6 5 ..0 2 6 4 ..8 2 7 5 ..1 3 0 5 .. 4 2 4 6 .. 7 2 8 1 .. 9 3 0 0 ,.6 2 8 2 .. 9 3 2 1 ,.1 2 8 0 ..6 300 .3 3 1 9 .. 1 2 8 5 .. 7 3 3 5 .. 0 2 9 3 .6 2 7 5 ,.6 3 5 2 .1 3 5 9 ,.1 3 4 0 ..8 2 6 4 ..2 2 7 4 .. 3 3 3 6 .. 3 3 2 9 .. 8 3 1 1 ..8 2 6 9 ..2 2 8 0 .. 3 357 .7 3 1 7 ..8 300 .5 3 1 8 .. 9 326 .1 3 1 9 ..1 2 7 0 .6 315 .9 3 1 7 ..8 3 2 2 .. 5 ompany Sanitized. Does not contain TSCA CB1 )I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 70 Female, Ii - 0 mg/ kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 281.2 292.0 269.3 260.1 342.4 333.9 296.2 288.4 303.9 2 7 2 .8 270.0 278.4 301.6 2 5 1 .9 295.6 298.5 2 7 0 .5 313.1 287.6 298.5 316.1 288.8 328.8 296.3 279.2 358.5 360.0 344.4 249.6 276.1 343.3 333.1 320.0 271.9 282.2 3 5 4 .1 316.2 310.2 321.8 347.8 320.1 276.1 329.7 323.0 338.8 285.9 304.5 276.6 264.3 353.0 336.2 297.9 298.9 305.2 280.0 274.9 290.1 314.4 255.6 299.1 306.6 288.4 323.6 293.9 294.6 318.4 292.4 327.9 304.9 286.5 358.2 358.2 355.4 263.0 278.1 342.8 335.7 325.9 268.0 282.2 367.3 3 2 6 .1 310.7 3 3 3 .9 373.1 333.4 281.3 329.7 333.3 338.4 Day 74 INDIVIDUAL BODY Day 77 Day 84 307.9 2 7 7 .6 320.8 287.6 3 0 2 .6 321.2 294.2 323.5 306.4 284.3 354.9 361.2 351.7 265.9 276.5 345.5 332.8 325.0 267.4 2 7 7 .0 284.0 3 1 3 .1 2 7 3 .0 263.3 359.9 336.7 295.6 301.7 309.7 2 8 3 .8 271.2 297.3 3 1 4 .8 2 6 0 .0 303.2 358.9 324.2 310.6 341.8 381.4 330.6 279.8 328.3 330.3 342.4 2 8 6 .8 313.7 2 7 2 .5 257.9 378.1 341.3 303.8 307.2 315.8 2 8 4 .8 286.0 296.9 3 2 4 .1 2 6 8 .0 311.0 3 6 0 .0 325.4 3 1 2 .6 349.9 395.9 334.7 2 8 8 .5 33 2 .9 3 3 9 .9 3 3 9 .6 WEIGHTS (g) Day 91 Day 98 DuPont-5386 Day 1 0 5 Day 11 2 2 9 7 .. 9 3 2 7 .. 7 2 8 0 .. 6 2 4 9 .. 7 3 9 5 ,,0 3 5 1 .. 3 3 0 9 ..2 3 2 3 .. 9 312 .4 286 .8 280 .1 301 .1 3 2 4 ..8 267 .4 299 .3 2 8 0 ,.8 282 .9 3 2 9 ..8 2 6 6 .. 7 3 1 9 .. 0 2 9 0 ..0 263 .4 3 3 0 ..2 2 7 4 ..8 3 1 6 .. 7 295 .5 279 .6 3 3 9 .. 4 283 .7 313 .3 3 6 5 .. 3 3 3 3 .. 7 3 1 5 .. 4 3 5 1 .,7 4 0 0 ..2 3 3 2 ..0 2 3 4 .. 3 3 2 8 ..2 3 3 9 .. 4 3 4 6 ..1 377 .7 3 3 3 .. 3 3 4 6 ..0 3 5 9 ..8 4 1 8 .. 5 3 5 2 .. 3 2 6 9 .. 3 3 4 6 .. 5 349 .8 3 4 9 .,0 3 8 5 .. 9 3 4 7 ,,2 3 5 0 .. 7 3 7 3 .. 3 4 2 6 .. 3 3 5 5 .. 3 2 8 7 ,. 3 3 2 6 .. 1 3 6 7 ..2 3 6 1 ..7 3 8 9 .2 374 .8 350 .0 387 .4 447 .5 364 .9 301 .3 SE TEST :DAY 369 .0 374 .0 Company Sanitized. Does not contain TSCA CB? H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 1 1 9 Day 1 2 6 Female, II - 0 mg/ kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 287.9 280.1 318.3 287.1 319.1 278.4 281.8 319.5 281.6 301.8 389.5 384.6 350.9 395.3 450.3 368.2 301.9 SE TEST DAY 365.1 378.5 105 Day 1 3 3 293.4 296.8 331.6 296.9 323.4 INDIVIDUAL BODY WEIGHTS Day 140 ly 1 4 7 Day 1 5 4 293.8 303.9 329.2 290.9 321.1 298.5 313.5 334.5 302.0 328.0 295.0 322.1 349.1 295.1 320.2 Day 16 1 299.2 322.7 352.3 314.9 325.3 Day 1 6 8 305.0 340.6 356.5 311.9 334.0 DuPont-5386 Day 175 303.8 334.0 355.8 314.1 333.0 Company Sanitized. Does not contain TS C A CBI )) ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________ __ ______ _________ DuPont-5386 Day 1 8 1 Female, j. 1 - 0 mg / kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 294.9 312.7 345.9 294.6 315.0 INDIVIDUAL BODY WEIGHTS (g) Company Sanitized. Does not contain TSCA CBI 590 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 Day 14 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 175.0 201.1 174.8 193.5 184.4 194.5 193.2 175.9 179.6 175.9 184.6 173.3 208.1 168.6 192.5 183.9 169.8 208.9 200.3 205.8 202.8 196.6 225.8 185.1 224.1 194.4 194.4 190.4 195.7 205.7 217.1 204.9 165.8 189.6 198.5 189.2 231.6 194.6 218.3 207.5 228.9 208.1 202.3 194.8 186.6 202.4 AK TEST DAY 0 224.3 187.7 204.3 196.2 185.7 237.1 218.2 225.2 230.0 215.2 262.3 206.4 251.8 219.9 228.8 219.8 230.4 218.5 251.8 223.3 189.0 209.2 225.8 201.5 254.6 233.7 240.2 215.6 238.2 209.3 219.8 216.2 209.7 214.9 239.8 205.8 223.1 227.6 214.4 255.4 237.1 247.8 254.8 237.3 273.5 226.6 270.8 228.9 251.3 237.0 256.1 244.2 249.4 242.0 199.8 230.4 245.3 INDIVIDUAL BODY Day 21 Day 28 223.6 284.1 247.0 268.4 236.2 264.3 233.8 242.6 230.8 227.7 225.2 269.2 218.0 246.3 242.2 239.4 275.7 258.7 266.7 274.1 249.4 302.3 242.2 298.1 256.2 273.9 256.7 276.5 274.0 276.7 26 3 . 6 212. 9 253.0 255.0 240.3 283.8 265.5 285.2 240.3 274.9 236.7 256.0 244.4 239.4 228.9 270.0 231.8 253.8 256.1 247.4 291.9 291.2 278.7 287.5 279.3 314.5 261.8 305.3 264.5 282.1 268.8 300.1 300.6 288.2 276.4 228.2 256.8 267.1 591 WEIGHTS (g) Day 35 Day 42 249.5 303.4 275.9 294.2 262.0 288.1 SE TEST DAY 2 9 270.0 258.1 248.0 247.9 257.3 307.5 282.5 305.4 275.2 301.2 266.3 264.3 258.9 254.2 279.4 239.2 260.0 268.5 260.8 304.4 294.0 284.8 299.1 286.0 351.5 270.4 319.3 278.4 296.8 274.4 313.3 305.0 303.7 285.2 241.3 268.9 275.1 283.5 253.1 275.6 280.0 273.3 314.2 285.1 295.3 317.5 298.1 366.9 289.1 334.5 285.4 306.4 293.5 325.4 315.9 329.3 290.5 247.3 271.0 289.3 Day 49 270.2 312.3 293.3 308.7 280.6 312.6 278.5 266.4 267.1 260.4 303.0 254.4 281.5 287.8 277.8 324.0 311.8 299.6 324.0 297.6 380.6 299.1 336.9 289.3 322.7 296.5 335.0 323.2 336.5 267.3 251.2 282.9 291.5 ) DuPont-5386 Day 56 274.3 321.1 316.6 322.5 245.9 315.2 287.1 284.4 271.2 254.0 296.1 265.7 283.3 290.5 281.0 319.8 301.9 303.1 327.3 299.3 387.5 297.5 354.2 298.4 320.1 305.3 349.6 329.0 322.6 298.2 263.4 282.3 292.7 Company Sanitized. Does not contain TSC A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 70 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 283.6 334.4 304.9 330.6 292.7 312.4 290.8 279.5 274.3 268.7 308.4 275.7 289.3 289.7 287.8 327.6 309.2 298.6 330.8 302.6 392.2 296.2 355.4 301.4 3 1 7 .5 305.7 355.1 344.7 339.2 298.9 272.4 287.6 300.2 281.6 349.3 319.6 341.4 306.2 316.7 289.9 295.4 285.8 271.5 312.3 282.5 303.5 302.5 294.6 328.9 314.2 309.9 335.1 313.8 398.6 305.9 365.2 295.7 318.8 307.8 356.7 343.7 331.6 305.3 266.8 293.4 310.1 Day 74 301.2 292.5 328.3 312.9 306.0 337.8 305.3 395.9 302.5 368.6 307.5 274.5 311.1 360.7 341.2 341.2 310.8 269,0 294.6 303.2 INDIVIDUAL BODY WEIGHTS (g) Day 77 Day 84 Day 9 1 288.3 355.7 322.6 349.5 298.3 319.8 294.8 300.6 295.2 267.6 304.9 278.7 298.3 291.1 361.8 331.7 348.7 295.8 325.7 304.5 299.7 299.8 273.0 304.7 284.7 300.4 286.8 359.1 328.6 353.5 290.1 323.4 303.1 303.1 296.5 280.9 312.6 294.6 302.8 Day 98 288.4 330.0 294.7 309.3 Day 1 0 5 283.7 329.7 297.8 319.4 DuPont-5386 Day 112 290.3 339.8 312.3 325.9 Company Sanitized. Does no! contain TS C A CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 1 1 9 Day 1 2 6 Female, IV - 2 5 mg/ kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 293.3 346.9 317.0 325.5 289.2 345.8 315.7 320.1 Day 1 3 3 298.2 358.8 321.9 330.6 INDIVIDUAL BODY WEIGHTS (g) Day 1 4 0 Day 1 4 7 Day 1 5 4 294.8 365.1 329.7 344.4 307.3 376.2 326.5 3 4 4 .8 314.6 371.9 340.6 349.9 Day 1 6 1 309.8 380.4 334.1 353.0 Day 1 6 8 313.3 387.9 337.7 355.6 DuPont-5386 Day 1 7 5 319.4 389.6 343.4 351.5 ;enipany Sanitized. Does not contain TSCA CB1 593 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Female 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 Day 1 8 1 2 5 mg/ kg/day 299.7 368.1 326.8 343.1 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 Company Sanitized. Does not contain TSCA CB!  H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 Female, VI - 100 mg/ kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 1 8 6 .5 184 .6 1 7 1 .5 173 .6 194 .9 2 1 4 .8 2 0 3 .2 164 .8 174 .8 1 6 6 .7 1 8 4 .6 1 8 0 .3 184 .9 1 6 1 .6 1 9 2 .7 1 7 9 .7 178 .2 2 1 8 .7 193 .5 1 8 6 .8 202 . 1 1 7 7 .0 1 7 5 .8 20 8 .5 1 8 3 .3 210 . 7 1 6 6 .3 1 9 2 .8 187 .4 1 8 5 .5 1 9 9 .9 201.3 200. 7 1 8 4 .6 1 9 4 .0 212 .. 9 2 0 3 ..1 198 .5 202 .,4 220 ..2 2 5 5 ..4 2 2 8 .. 9 1 8 0 .. 3 1 9 7 ..1 1 9 1 .,8 2 1 3 ..6 202 .. 4 2 0 6 ..0 1 8 4 ..6 2 2 6 ,. 1 2 12..1 2 0 6 .. 3 2 3 7 ,.1 2 1 6 ..6 2 1 5 ..2 2 2 2 ..8 2 0 5 ..0 200 ..8 2 4 0 .. 9 2 0 6 ..6 220 ..8 1 9 6 ..0 2 1 1 ..6 2 1 0 ..6 1 9 8 ..9 2 20..0 22 1 ., i 2 1 9 ,, 1 2 0 6 ..3 224 .8 Day 14 2 3 0 .. 5 2 2 1 ..6 2 2 1 ..2 2 1 3 ,. 3 2 3 4 ..2 2 7 6 .. 3 2 5 0 ..1 1 9 7 ..1 2 0 7 ..6 212 .. 9 2 3 2 .. 9 2 0 7 ..8 2 1 8 .. 5 2 0 1 ..6 2 3 6 ..1 2 3 3 .. 1 223 .6 2 7 5 ..6 2 3 6 ,. 5 2 3 1 .. 0 2 5 3 .. 3 2 2 9 .. 4 2 1 8 .6 259 .5 2 2 8 .8 253 .6 2 1 3 ..2 2 2 7 .. 4 2 3 2 ,. 6 2 2 6 ,. 9 2 2 8 .. 4 2 4 9 .. 5 2 4 4 .. 1 2 2 9 .. 1 2 4 8 .. 5 INDIVIDUAL BODY Day 2 1 Day 28 2 4 7 ..8 2 4 3 .. 7 2 3 0 .. 7 2 3 3 ..0 2 5 8 ,.0 2 9 4 ..8 2 7 2 .. 3 2 1 4 .. 9 2 1 9 .. 9 2 3 4 ..8 2 5 0 .,0 2 3 4 ..6 2 3 6 .. 7 2 2 2 ..1 2 6 6 ..0 2 5 2 .. 5 2 3 9 ..9 2 7 8 .. 4 2 5 2 ..6 2 4 1 ..2 2 6 7 .. 7 2 3 4 .. 1 2 2 6 .0 2 8 5 .. 9 244 .2 2 7 3 .. 9 2 1 9 .. 7 2 4 0 .. 7 2 4 8 ..6 2 4 0 ,. 9 2 5 0 ..6 2 6 1 .. 8 2 5 3 .. 5 2 3 9 .. 7 2 6 1 .. 3 2 6 1 ..8 2 4 0 .. 7 2 4 6 .. 6 2 4 8 .. 9 2 6 8 .. 4 300 .1 2 8 2 .. 4 2 2 3 .. 3 2 3 2 ,. 9 2 4 3 .. 8 2 5 3 .. 0 1 9 8 ..4 244 .1 2 3 3 .0 279 .9 2 6 3 .. 7 2 6 0 .. 9 300 .3 263 .9 261 .5 280 .8 262 . X 243 .6 3 1 1 .0 257 .9 293 .9 245 .7 2 5 6 .8 2 5 1 .8 261 .5 262 .9 2 8 1 .6 2 6 3 .6 243 .9 275 .1 595 ) WEIGHTS (g) Day 35 Day 4 2 Day 49 DuPont-5386 Day 56 2 7 1 ., 3 2 6 2 ..6 2 6 2 .. 5 2 6 4 ..0 2 7 9 .. 4 3 2 4 .. 3 2 8 7 ,,8 2 3 6 .. 7 2 4 2 ..0 2 4 8 ..0 2 5 9 .. 9 1 9 6 .. 4 2 4 9 ..2 222 . 3 2 7 9 .0 2 7 8 .. 5 2 6 3 .. 9 3 0 7 .. 3 2 7 5 .. 1 2 7 3 .. 7 293 .4 267 .5 251 .3 284 .4 2 6 4 .2 297 .9 2 5 4 .1 2 7 0 .. 6 2 7 0 .. 3 269 .2 273 .5 294 .9 279 .9 260 .7 2 8 9 ..0 2 8 0 ..8 2 6 2 ..8 2 6 1 ..6 2 8 3 ..5 2 7 9 ,.6 3 3 1 .. 7 2 9 4 ..8 2 5 5 .. 7 2 5 9 ..0 2 6 6 ,,2 2 7 0 .. 9 1 8 8 .. 6 2 6 3 ..6 2 4 8 ,. 7 3 0 0 .. 4 2 9 6 ..5 2 7 5 .. 4 3 1 9 .. 7 2 8 3 ..2 2 7 7 ..8 2 9 2 .. 4 283 .5 267 .8 275 .3 269 .3 3 1 0 .. 8 2 7 3 .. 1 2 8 4 ,. 7 2 8 2 .. 3 2 8 5 ..2 2 7 7 ..2 3 0 0 .6 296 .4 263 .3 3 0 2 .. 4 2 7 8 .. 3 2 8 4 ..1 2 6 9 ..5 2 8 5 .. 5 2 8 7 .. 3 3 1 4 ,. 7 2 9 9 .. 7 2 5 1 ..1 2 5 0 .,8 2 5 5 ., 7 2 7 3 ,,0 2 2 4 .8 2 6 8 ..6 2 5 6 .5 3 0 7 ..0 2 9 6 .. 9 2 8 3 ..0 3 2 2 .. 4 2 8 9 .5 3 0 3 ..2 310 .7 290 .7 267 .3 308 .9 2 7 5 .6 3 1 7 ..0 2 7 4 .9 2 9 9 .. 4 2 8 2 .. 3 289 .4 2 9 3 .2 306 .8 305 .5 2 7 5 .0 3 1 0 .. 4 2 7 9 .6 293 .3 268 .8 2 8 4 ..5 2 9 6 ..8 3 2 3 .. 3 303 .5 2 4 9 .. 5 2 5 7 ..7 2 6 7 .. 3 2 7 5 ..0 2 3 1 ,,8 2 6 9 ..2 2 5 9 ,. 9 2 9 3 .. 4 3 0 6 ., 1 2 8 4 .. 9 3 1 1 ..2 2 9 6 .. 2 3 0 4 .0 308 .3 290 .5 275 .8 304 .4 2 8 3 .8 3 2 1 ..2 2 8 4 ..0 3 0 0 .. 6 2 8 7 .. 6 291 .3 292 .5 313 .4 309 .1 2 7 2 .2 313 .5 C om pany Sanitized. D oes not co n tain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 63 Day 7 0 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 289.7 290.2 272.4 297.5 292.2 327.7 305.1 264.3 262.5 274.2 285.9 238.9 274.3 251.7 307.2 305.6 290.1 318.3 293.9 309.2 308.6 299.4 269.8 319.2 284.1 330.6 285.5 307.5 284.5 305.4 284.7 316.7 304.0 275.8 317.1 290.8 312.1 272.6 305.7 304.5 320.5 315.7 274.5 264.9 290.8 296.4 252.4 282.7 264.8 300.3 316.3 293.2 315.6 292.5 313.7 315.1 306.1 278.1 338.6 280.4 325.5 288.0 317.3 290.3 308.8 281.6 313.4 313.6 284.2 316.9 Day 74 316.2 296.9 314.7 290.6 310.0 323.7 311.0 274.0 298.5 274.5 327.7 291.0 317.5 286.8 310.7 291.6 315.1 309.9 280.5 315.3 INDIVIDUAL BODY WEIGHTS Day 77 Day 84 Day 91 295.4 315.7 278.2 307.6 302.7 324.3 314.9 275.9 263.4 290.4 293.6 257.3 284.2 260.8 317.6 294.0 315.0 276.7 311.5 305.7 316.9 320.3 271.2 270.1 293.3 302.8 254.5 298.9 261.2 311.3 295.7 319.2 281.9 313.0 315.0 328.1 318.3 277.0 270.6 286.1 300.7 258.5 296.6 261.3 314.5 Day 98 306.2 270.7 298.2 256.5 301.6 Day 1 0 5 306.5 276.0 301.9 267.9 305.8 DuPont-5386 Day 1 1 2 318.8 270.9 311.1 227.2 314.1 Company Sanitized. D oes not contain TSCA CBI ) I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________ ________________________________ _ DuPont-5386 Day 1 1 9 Day 1 2 6 Female, VI - 1 0 0 m g / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 321.8 220.9 312.3 242.5 313.6 317.8 263.9 311.3 248.1 325.1 Day 1 3 3 317.5 277.8 329.7 265.7 316.3 INDIVIDUAL BODY WEIGHTS (g) Day 1 4 0 Day 1 4 7 Day 1 5 4 Day 1 6 1 323.5 278.1 321.6 265.2 327.2 333.9 281.1 327.2 269.6 342.7 334.4 281.5 342.6 283.6 338.3 339.7 291.7 338.9 280.0 348.5 Day 1 6 8 341.4 293.1 342.1 281.5 351.7 Day 1 7 5 348.0 294.2 342.2 283.3 3 6 4 .6 Company Sanitized. Does not contain TSCA CBI 597 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 181 Female, VI - 1 0 0 mg / kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 327.2 286.1 328.1 277.7 356.8 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 CSmPa"y Ssm1fee<t D "Ol contain TSCACBr )> H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 0 Day 7 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 186.4 202.6 195.9 181.0 168.9 173.1 166.9 191.2 184.7 196.2 169.0 196.1 180.8 164.2 224.7 197.0 181.1 217.9 181.7 197.2 205.9 175.6 211.6 181.8 190.6 188.2 196.4 209.8 206.8 201.9 172.8 193.0 215.0 204.2 189.5 175.6 205.8 188.1 178.2 186.6 189.9 203.8 168.8 192.9 171.0 212.8 239.1 221.5 198.5 192.0 187.3 190.0 211.5 212.0 213.7 194.4 215.4 210.2 185.1 246.4 226.2 201.7 250.1 208.0 220.0 230.4 196.4 234.6 198.0 220.0 215.3 227.8 245.4 253.5 233.3 196.1 215.4 237.4 227.7 213.7 197.7 251.0 210.9 203.9 207.0 215.8 229.6 189.3 221.5 190.9 Day 14 233.2 261.6 246.1 216.8 217.0 202.0 211.3 240.5 239.1 244.9 210.4 236.2 220.6 204.0 266.1 240.3 213.8 278.8 221.6 234.7 244.6 223.4 261.2 223.5 243.6 234.9 249.3 271.6 275.5 256.6 217.5 232.4 275.6 258.2 232.5 224.4 274.7 230.8 227.9 226.9 235.4 244.6 217.8 244.5 220.3 INDIVIDUAL BODY Day 21 Day 2 8 244.7 294.3 256.2 224.9 234.4 227.1 227.2 257.6 249.3 252.2 231.3 250.6 227.3 222.6 291.6 252.2 230.6 298.3 242.8 251.0 264.1 237.1 284.3 235.3 261.0 237.1 261.7 293.6 292.2 268.0 236.5 250.4 288.9 272.6 245.3 222.7 288.9 230.3 242.4 235.8 254.4 255.8 221.8 256.7 230.8 252.1 289.3 268.3 234.3 251.6 232.4 244.1 268.5 278.2 269.5 240.8 259.1 236.8 238.4 300.9 270.5 245.8 314.8 251.7 265.5 281.5 250.6 290.3 246.3 274.8 259.4 281.8 310.1 313.9 276.1 253.8 757 1 299.7 289.3 249.2 232.8 289.7 252.4 246.9 235.6 262.5 275.1 230.0 270.1 245.1 599 ) WEIGHTS (g) ay 3 5 Day 42 Day 4 9 DuPont-5386 Day 56 2 6 6 .. 7 3 1 8 .3 2 8 2 .. 7 2 4 1 ..2 2 5 7 .. 1 2 5 1 .. 3 2 5 7 .. 4 2 7 0 .. 6 2 8 9 ,. 4 2 8 2 ..0 2 5 2 ,. 7 2 6 2 ..6 2 5 5 .. 5 240 .6 3 1 0 ..2 278 .2 2 5 1 .6 3 1 4 .. 6 2 5 7 .. 9 278 .4 2 9 6 .. 5 261 .7 298 .1 2 5 7 ..8 288 .5 267 .9 2 9 0 .. 7 321 .3 3 2 6 .1 301 .4 2 5 9 .6 275 3 3 1 0 .2 297 .3 263 .1 241 .7 312 .7 2 5 9 .2 251 .5 247 .7 269 .1 2 8 4 .2 235 .1 280 .7 2 5 4 .0 2 7 6 .0 3 3 4 ..2 289 .1 2 4 8 ..6 2 7 9 .,8 2 6 8 .7 2 6 0 .. 3 2 8 5 .. 3 2 9 4 ,.2 2 8 0 ..0 2 5 9 .. 7 2 6 7 ..0 2 7 5 ..6 2 5 3 ,. 4 3 2 0 ..1 2 8 7 ..0 2 6 1 .6 3 2 2 ..6 2 6 2 .. 1 2 8 3 ..2 3 0 6 .. 4 2 7 0 ..6 308 .5 2 5 6 .. 3 3 0 4 .. 4 2 8 0 .. 4 2 8 7 .. 5 3 2 5 ..2 3 3 0 ..2 3 0 6 .8 2 6 3 .. 7 2 8 4 .8 3 1 6 .6 3 0 9 .. 1 2 6 6 ..1 251 .5 3 1 8 ,.8 2 6 4 ..2 2 6 9 .6 2 5 0 .. 9 2 7 6 ,. 5 300 .4 2 5 0 ..6 2 8 7 .8 266 .9 2 7 4 .. 7 3 3 8 ..0 292 .7 2 5 2 .. 3 2 7 2 ..8 2 6 1 ., 3 2 6 6 .. 3 2 8 5 .. 7 3 0 7 ..0 2 9 7 ..1 2 6 4 .. 4 2 7 4 .. 7 2 9 4 ,.6 2 3 9 .. 3 3 2 6 .. 5 2 8 6 .. 1 2 6 2 .2 3 3 9 ..8 2 7 0 .. 1 2 8 8 ..6 3 2 0 .. 1 2 7 4 .. 9 3 1 4 .8 2 7 3 ,. 7 3 1 5 .. 4 2 3 2 ..2 2 9 4 .8 3 3 6 .. 7 3 3 3 .2 311 .8 2 6 9 .2 297 .3 317 .1 315 .5 2 8 3 .6 259 .9 287 .3 219 .7 272 .0 258 .3 289 .9 313 .1 257 .1 3 0 5 .0 2 6 9 .6 279.5 329.9 302.5 254.3 287.5 252.4 269.5 286.6 310.1 300.5 271.3 273.7 276.4 178.9 333.3 284.9 261.4 336.5 271.6 292.2 319.9 269.2 290.1 268.3 325.4 AK TEST DAY 297.2 334.2 331.9 292.2 266.6 299.4 323.9 305.6 281.0 256.4 238.7 230.1 235.9 255.3 281.8 312.1 251.5 293.1 271.4 Company Sanitized. Does not contain TSCA CBI I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 63 Day 70 Female, VIII - 2 5 0 m g / kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 543456 643423 643345 643351 643358 643444 643474 643441 643481 283.2 308.7 307.5 251.8 280.2 246.8 268.6 272.0 317.7 274.4 265.1 287.2 290.1 235.9 334.5 275.8 260.3 323.0 276.1 295.1 313.1 267.2 240.7 269.8 328.3 2 5 1 .4 332.5 332.0 279.3 249.8 310.3 324.1 305.6 279.2 265.8 306.1 249.6 268.3 210.5 288.1 270.3 254.3 263.5 271.8 285.9 297.0 307.5 250.0 291.0 268.7 274.4 284.0 325.5 FD TEST DAY 252.3 292.4 291.1 247.5 342.4 231.5 255.4 320.5 279.0 292.5 298.3 204.8 195.7 229.9 281.5 297.8 324.5 325.9 288.7 261.0 315.7 332.2 279.8 263.7 263.7 324.2 248.7 268.2 262.0 287.1 262.8 261.6 299.5 274.2 Day 7 4 214.9 229.0 326.6 283.5 289.5 283.0 261.7 269.0 278.6 325.4 310.2 331.4 297.6 267.5 232.5 316.9 326.0 297.9 221.0 INDIVIDUAL BODY Day 77 Day 84 2 6 9 ..9 2 8 9 .. 4 3 0 1 ..9 2 5 7 .,0 2 7 5 .. 9 2 6 4 ,.2 2 6 2 .. 7 2 8 5 ..1 3 2 8 .. 9 2 3 0 .. 7 2 8 7 ..0 2 5 6 ..0 2 4 4 ..0 2 8 5 ..8 2 9 9 .. 5 3 3 1 .. 1 3 1 3 .. 6 2 5 7 ..8 288 .9 279 .4 278 .1 3 0 2 ,. 7 339 .7 272 .7 308 .7 3 0 0 .2 264 .3 330 .1 265.2 319.4 250.2 262.2 276.3 290.8 283.4 238.9 307.7 255.5 268.1 345.7 279.1 290.0 275.6 309.7 311.7 267.9 328.2 274.3 600 WEIGHTS (g) Day 9 1 Day 98 Day 1 0 5 2 9 9 .0 3 4 8 .6 2 9 6 .9 2 5 4 ..5 2 9 7 ..6 2 7 7 .,4 2 6 8 .. 3 3 0 2 ..8 3 4 9 ..8 2 7 4 ..0 3 1 2 .. 3 3 0 8 .. 7 2 6 1 .. 5 3 4 7 ..9 276 1 298 7 317 6 272 7 369 5 280.6 298.7 324.0 271.5 384.6 DuPont-5386 Day 1 1 2 284.3 303.2 326.8 285.8 398.5 276.7 337.1 283.5 280.5 280.0 323.1 313.9 269.3 336.0 285.9 275 329 288 296 283 333 303 280 350 296 1 2 9 9 3 1 2 2 7 3 275.2 335.1 297.0 307.9 292.1 350.1 307.9 275.1 354.2 301.9 277.7 333.4 310.5 328.3 300.2 358.7 308.9 282.5 368.9 311.8 Company Sanitized. Does not contain TSC A CBI II H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 119 Day 126 Female, VIII - 250 mg/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 286.2 308.6 325.5 283.6 404.8 277.7 340.7 309.7 328.5 301.5 372.2 323.0 280.1 382.3 313.6 280.8 310.4 331.7 290.9 411.1 Day 133 288.9 331.5 343.4 289.1 416.6 INDIVIDUAL BODY WEIGHTS (g) Day 140 ly 147 Day 154 292.1 348.6 335.9 291.3 422.0 305.5 365.2 348.0 296.9 431.4 318.0 373.2 357.9 297.0 437.3 Day 161 316.4 384.4 364.6 302.4 442.6 Day 168 316.7 363.1 373.9 297.6 444.5 ) DuPont-5386 Day 175 322.9 359.2 376.9 298.6 450.8 Company Sanitized. Does not contain TSCA CB 601 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 181 Female, VIII - 250 mg/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 312.0 341.1 368.9 286.1 429.7 INDIVIDUAL BODY WEIGHTS (g) DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX D INDIVIDUAL FOOD CONSUMPTION Company Sanitized. Does not contain TSCA CW 603 H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION EXPLANATORY NOTES DuPont-5386 Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed. Last day o f food consumption data collection for rats designated for reproduction evaluation. Day 83-89 Rats designated for the 3-month recovery period were temporarily housed in metabolism cages for urine and feces collection. Food consumption data was not collected for these animals during this period. Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for 90-day exposure period were sacrificed. Day 119 Last day o f food consumption data collection for animals designated for the one-month recovery period. Day 125 Male and female rats designated for the one-month recovery period were sacrificed Day 175 Last day o f food consumption data collection for animals designated for the 3-month recovery period. Day 181 Male and female rats designated for 3-month recovery period were sacrificed. Abbreviations AK Accidentally Killed FD Found Dead SE Sacrificed in extrem is company Sanitized. Does not contain TSCA CBI 604 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL! t'UUJJ uuNSUMPTION Day 7 Day 14 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 6431S5 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 28.6 25.0 25.4 25.8 29.3 26.5 25.0 29.4 27.7 23.8 25.3 24.0 24.1 28.4 24.3 23.3 26.8 22.9 22.4 23.6 26.0 22.7 24.7 28.6 26.3 29.7 26.5 26.5 25.2 24.4 28.4 29.7 21.5 23.8 25.2 30.0 26.6 24.3 27.3 26.5 23.0 25.3 24.4 23.2 27.7 31.1 26.4 27.7 25.9 30.4 28.6 27.4 33.6 29.4 25.4 27.2 22.1 27.2 29.1 27.0 25.8 27.7 22.6 23.8 25.7 25.3 24.1 27.2 31.8 27.9 32.6 27.7 26.1 26.6 25.8 31.8 33.2 23.0 23.5 27.0 32.9 29.1 27.7 30.4 28.3 25.5 27.0 23.5 24.6 28.2 Day 21 28.7 27.4 27.0 29.1 32.5 30.5 25.2 32.2 31.7 25.3 29.9 25.7 30.5 31.5 28.8 26.2 29.0 24.7 23.9 27.4 27.0 25.0 27.8 30.6 28.8 33.2 29.0 29.4 27.7 28.9 31.4 32.0 24.9 22.7 25.7 31.8 30.4 28.5 31.7 29.6 25.7 28.2 24.6 26.3 27.4 Day 28 31.4 27.0 28.8 29.6 33.0 31.2 24.6 31.7 31.2 26.9 30.0 22.2 29.0 30.6 27.6 26.5 30.9 24.1 23.2 28.0 26.9 24.8 28.4 31.7 30.5 32.1 28.7 28.3 26.4 27.0 32.0 32.4 25.3 24.0 25.1 31.0 29.4 27.1 29.4 29.9 24.9 27.4 24.2 25.5 30.3 Day 35 31.3 29.2 28.4 29.0 33.6 32.1 25.5 30.9 30.5 25.8 32.3 26.4 29.3 29.5 27.7 26.4 30.3 23.9 23.8 28.2 27.3 25.1 29.2 30.4 29.9 32.8 27.3 28.1 25.2 25.3 30.8 31.9 23.9 23.8 25.2 31.6 28.7 29.2 29.6 32.7 27.2 28.1 27.3 29.2 29.8 Day 42 31.5 30.1 27.4 30.3 34.6 31.2 24.9 31.7 31.6 26.5 29.8 27.1 29.9 31.1 29.2 27.5 30.0 24.2 25.8 29.3 27.0 24.8 30.1 33.1 27.5 31.6 27.4 28.6 24.8 27.3 31.3 32.4 24.9 25.2 27.2 31.4 29.6 27.7 29.0 33.2 28.0 24.4 25.3 27.2 29.9 605 (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 29..2 26..5 26 .8 28 .4 30..1 27 .1 25..4 28..8 30..0 28..3 30..4 28..7 30 .7 32 .8 29 .0 29 .1 32..0 23 .8 24 .5 27 .7 28 .2 25,.5 31 .2 34..8 31 .1 34 .3 29..2 31..6 27 .6 30 .4 31..2 35 .9 25 ,.9 27..3 27 .7 31..9 30 .1 30..1 29..6 32 .2 27 .2 26..9 26..8 29..4 27 .8 31..2 32.,0 28..6 30 ..8 34 .,6 31..6 26. 8 33..2 34..2 25. 1 30..9 27 .6 30 .0 30 .2 27..3 27 .6 29..6 23 ,.0 25..1 26 .3 28 .3 24..0 29 ,.3 33 .5 30..0 34..3 29..3 30 .,6 26..5 31..2 31..2 35 .2 25 .5 26..5 29..5 30..3 29 ,9 28 ..7 31..2 30 .7 27..0 24.,0 26..2 27..6 28 .8 33..3 33 .1 29..4 28..5 37..4 31..3 27..5 34..3 33 ,.8 24..7 23..0 26..6 24..0 31..3 26..5 26 .6 29..8 22 .8 25 .6 28 .6 28 .5 24..2 29 .8 35..0 29 .2 34 .3 28..8 30,.0 26 .9 31 .0 30..8 35 .0 26 .5 27..8 28 .7 33 .1 30 .4 29 .7 30,.1 30..4 28..0 12..8 26 .1 26..3 29..9 29,.5 30..4 26..9 30..3 33 .3 32 .5 27..2 33..2 29 .9 27 .4 29..3 25 .4 26..7 32..5 26..9 22 .9 30,.1 23 .5 24 .2 27 .1 27 .8 26..2 29..8 34..2 28 .5 34 .1 28 .9 30 .0 26 .2 32 .2 32..7 35 .9 25 _9 27..3 29..0 32..6 32..8 28 .7 30..6 29..7 27,.9 19..9 26 .1 27,.4 28 .5 impany Sanitized. Does not contain TSC A CB1 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 74 Day 77 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 34.0 28.7 30.9 32.2 26.0 26.1 27.7 30.6 27.0 31.2 33.4 28.5 35.6 30.6 32.5 30.1 38.5 33.1 40.3 24.7 30.2 28.6 27.3 30.7 32.5 29.7 25.9 34.2 32.8 27.3 25.2 30.3 26.4 26.4 28.0 28.0 30.4 32.8 23.5 30.1 28.4 26.3 17.3 25.0 27.7 Day 84 29.0 29.0 27.0 30.7 33.6 29.7 26.3 32.5 32.2 26.7 27.9 30.4 25.9 24.2 26.6 27.8 30.1 32.0 24.9 28.1 28.4 26.9 15.9 24.9 30.4 INDIVIDUAL FOOD CONSUMPTION Day 90 Day 98 Day 105 28.5 27.5 25.2 28.3 33.1 25.1 25.5 32.7 31.5 22.9 21.2 27.8 24.6 26.9 31.1 27.9 26.4 27.4 31.0 29.0 27.3 23.8 27.2 28.2 29.4 29.2 25.6 28.5 27.6 24.6 24.2 25.0 28.8 24.9 27.4 26.3 33.5 33.1 28.7 29.1 30.8 26.8 25.4 27.0 24.0 28.2 28.6 32.6 31.6 31.6 29.6 32.6 28.0 12.4 26.3 606 (g/day) Day 112 Day 119 Day 126 DuPont-5386 Day 133 23 .6 31..0 27 .6 26..0 28 6 17 1 25 8 24 6 27.6 28.5 27.4 26.1 27.4 28.1 29.5 25.0 23.5 27.8 29.9 31.4 32.5 31.3 29.0 32.3 27.2 28.2 28.7 23 1 27 4 29 7 29 5 32 8 30 8 27 3 30 6 25 4 14 4 26 1 27.1 27.5 Company Sanitized. Does not contain TSCA CBf I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 140 Day 147 Male, I - 0 mg/kg/day 643241 643300 643143 643205 643235 643288 643150 643189 643185 643210 643268 643232 643265 643239 643270 643148 643284 643229 643196 643176 643218 643207 643280 643271 643211 643163 643197 643242 643251 643155 643147 643276 643237 643226 643195 643246 643253 643262 643172 643303 643304 643162 643254 643145 643204 28.3 33.1 29.3 21.3 27.7 29.2 30.7 30.2 26.0 13.9 Day 154 29.9 31.7 31.4 26.8 32.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 Day 168 Day 175 Day 181 33.0 33.9 32.2 28.5 29.7 30.2 31.8 27.5 29.2 34.5 33.1 27.4 24.7 28.8 27.5 24.3 34.7 28.4 29.8 23.7 607 ) DuPont-5386 ,,ampany Sanitized. Does not contain TSCA CBi ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 29..4 23..2 23..6 25..6 23 .8 26..7 27 .2 25..0 25 .4 26 .4 24 .4 23 .2 23 .6 23 .5 24 .8 19 .1 29 .3 24 .6 29 .8 22 .1 26 .5 28 .0 28 .9 24 .4 23 .6 26 .3 30 .2 28 .2 27..7 27 .0 26 .5 7.3 .0 ">"!7.-"J3 28 .7 26..0 29..9 24 .9 26..6 25..6 30 .9 30 ,.9 29..1 24..9 28..6 28..1 25..4 27 .9 24,.2 25..6 26 .4 21 .2 32..4 25..4 29 .6 24 .1 27 .8 29 .2 33 .7 27 .7 26..7 28 .3 33 .2 31 .4 27..7 29 .6 25 .6 23 .5 28 7 28 .6 27 .0 Day 21 29..3 26..3 25..6 27..7 32 .3 31,.7 29..3 23..3 29..2 29 .3 25..4 31 .1 24..1 25..9 27..2 21 .5 32 ,.8 25 .7 30 .4 24 .2 29 .2 31 .1 33 .4 25 .8 26 .0 31 .8 34 .5 30 .3 26 .4 29 .8 25 .2 22 .9 28 .5 28 .0 27 .4 INDIVIDUAL FOOD CONSUMPTION Day 28 Day 35 Day 42 29..9 26..6 26..3 28..6 32 .,7 31..2 29,.1 23,.6 29.,4 28..7 25..0 30 .9 24 .9 25..4 26 .4 21 .6 32..1 26..7 30 .3 25 .5 30..2 31 .9 31 .6 27 .6 27..7 30 .1 35 .4 32 .5 23..7 29 .8 24 .6 22 .6 29..2 28 .5 28 .0 32..8 28.,4 26..0 29..8 35.,4 34.,0 31..2 26..0 32..1 28..7 26..6 33..3 27..4 27 ,.1 30..4 23 .9 31..1 27..0 32 .0 24 .3 30..6 30..8 32 .2 27 .4 28..9 32..7 34..0 32 .0 19 .7 29 .8 26 .5 24 .2 29 .5 29 .4 28 .6 29 .0 29 .0 27 .2 29..2 33 .6 34..9 31..7 24..4 32 .4 28 .1 25..5 33..4 28 ,.1 25..4 28 .4 22 .9 31,.6 25 .3 31..1 25 .2 30..8 29 .0 32 .3 25 .5 26,.0 30..3 32 .5 30 .8 27..7 29 .3 27 .0 23 .2 31 ,2 29 .3 28 .3 608 ) (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 27 .4 25..3 24 .8 26..1 30 .0 29 .5 28 .6 23 .4 27 .8 25..6 27 .7 30 .1 22 .0 26..7 29 .5 22 .9 32 ,.7 25..7 30 .4 25..3 31..2 13..2 33 .2 28..4 25..2 31..0 35..2 31..9 25. 0 29..1 27 .8 23 .8 32..1 29 .5 28 .9 30 ,.7 29..7 26 .3 29..2 35..5 34,.4 33 .1 25 .1 31 .4 28 .6 25 33 .0 25..8 26..3 30 .4 23 .2 34 .0 25..1 29 .5 26 .0 30,.5 28 .8 33 .1 28 .7 29..1 31 .4 35 .4 32 .0 2 4 ..9 29 .2 27 .6 14..2 31,.1 29..6 29 .2 29 .3 28..4 27 ,.8 29..3 35.,1 32..5 34..0 24..1 30..1 24 .4 23 .3 30..5 25..3 26..6 29..9 23 ,.3 32 .7 26..0 31,.5 25..8 31..8 29..4 32..9 27..7 29..2 31..8 33 .8 30 .6 21..5 30..8 27 .3 23 .6 30..8 30..2 29 .0 27 .1 28..6 28 .3 28 .0 33 .,3 35,.0 31..9 22..8 26..1 27..2 24..8 33 .0 24..3 27..4 28 .8 23..2 32..1 25..0 32 .0 25 .9 32,.0 29..0 34 .4 28 .5 29..4 32 .2 32 .8 32 .5 22..8 30..6 26..6 24 .9 30..2 30 .2 28 .8 company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 74 Day 77 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 22.3 33.9 25.8 29.7 25.0 31.1 33.3 32.1 30.3 29.7 29.9 36.2 32.8 33.6 32.0 28.8 270 31.1 30.9 27.8 29.3 28.9 27.4 24.6 33.0 33.4 30.8 22.1 25.6 26.3 24.2 29.8 22.9 25.3 27.0 Day 84 25.0 29.7 29.8 26.6 33.8 32.8 30.9 23.2 28.8 28.6 24.4 28.2 24.7 26.1 26.0 INDIVIDUAL FOOD CONSUMPTION ig/day) Day 90 Day 98 Day 105 Day 112 20.5 27.9 29.8 24.1 30.6 32.6 30.4 23.4 27.7 26.0 23.2 24.6 22.5 24.8 26.7 24.0 29.3 25.3 26.0 29.3 26.2 31.3 24.4 28.7 28.0 26.3 27.0 25.3 30.3 29.7 Day 119 26.2 27.0 18.4 29.0 28.9 Day 126 25.9 27.4 25.0 26.8 26.1 DuPont-5386 Day 133 26.5 32.7 28.3 16.2 28.9 "'ompany Sanitized. Does not contain TSCA CB1 609 {1-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 140 Day 147 Male, III - 25 mg/kg/day 643173 643290 643272 643292 643228 643308 643264 643240 643180 643179 643202 643310 643306 643305 643293 643287 643188 643230 643170 643144 643277 643214 643261 643166 643153 643177 643198 643291 643184 643167 643223 643233 643183 643219 643263 25.0 30.6 26.9 31.4 29.6 26.7 31.7 27.7 31.4 30.2 Day 154 28.6 30.9 29.1 31.9 32.7 INDIVIDUAL FOOD CONSUMPTION (g/'day) Day 161 Day 168 Day 175 Day 181 27.1 29.7 26.9 29.2 31.2 26.9 30.6 27.5 29.7 31.3 27.5 30.2 26.3 30.0 30.9 23.1 27.4 23.0 25.8 25.2 DuPont-5386 Company Sanitized. Does no! contain TS C A CBl _ !) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 23,.8 25..9 26..8 26..5 29..5 25..9 28 .9 28 .0 26..1 24..1 22 .4 23 .4 20..8 24 .6 21..6 23 .4 26..3 27 .6 27 .,6 29 .3 26,.4 28..4 24..9 22 .5 28..1 27 .8 26..7 25..8 28 .3 26..9 27 .3 25..5 28,,4 26 .3 28 .0 23 .1 30. 2 29. 5 27 .7 32 .3 28 ,.0 30. 8 27 .8 26..9 24.,5 25..5 27 .1 21..6 27 .9 22 .8 25..1 30..7 29..2 28 .2 31..8 29..1 32 .,7 27 .5 24..4 29,.4 30..2 30 .0 28 .9 26..4 30..1 30. 3 27 .3 30..0 27 ,4 30..0 Day 21 INDIVIDUAL FOOD CONSUMPTION Day 28 Day 35 Day 42 25..3 28 .7 27 .2 30..4 28 .7 28 .5 29 .6 27. 2 26..3 24.,9 26..2 27 .,4 22 .9 28..1 24 .5 24 .9 31..7 29..2 27..8 31..9 29 .7 33..5 26 .1 24 .6 29 .8 30..2 30..2 29 .4 27 .8 28..4 29 .4 27 .9 29 .9 26 .1 28 .9 25. 8 2 8 .0 28 .1 29. 6 29. 7 29 .7 28. 8 28. 7 25. 4 26..0 26..8 28. 3 26..1 28 ..9 24..0 26. 1 32..8 30..6 27..8 35..4 30. 3 33 ..4 27..8 24..2 31..2 30..9 30..9 32 .3 28..5 30. 1 31. 5 28 ..3 .6 25 .9 29..3 24. 4 31. 3 29 .5 29 .6 58 .6 29 ..8 29. 0 28. 6 27..3 24..8 27 ..0 30..6 27..3 29..4 24 ..1 26. 5 32..8 30 ..8 28 ..1 33 .0 31..3 33 .,6 28..2 24..8 31..5 29 ..1 30..0 30 ..6 28 ..6 2 8 .5 31. 1 27 .9 32 .,8 27 ..7 30 .9 22 .9 30..0 30..1 29 .1 31..8 30 .2 31..0 28,.4 27..6 25..1 26..4 29 .1 26,.6 31..6 23 .8 27..4 31..7 30 .0 27 .8 32 .1 30 .4 33 .5 29 .4 23 .8 30 .0 30..3 31 .1 30 .5 28 .0 29..5 32 ,.6 27 .1 31 .4 28 .5 30 .2 611 ) (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 22..9 28. 6 2 6 .4 25. 8 15 .1 27 .4 28. 8 26. 7 24..5 23.,4 26..9 29..7 27..9 31..1 28..4 29..8 31..9 29..5 26..7 32 .1 30 .9 32 .9 29..0 25..4 30 .7 30..3 32..4 31..1 31..2 31..2 31..6 27..1 33 .3 28..9 30..2 24.,5 30..8 27 .6 28..8 27 .1 31.,8 30..8 30.,8 26..6 26..1 26 .9 29..9 26..8 31..4 25 .3 27..0 32..2 30..4 28 .5 31 .0 30 .7 33 .9 27 .1 25 .3 31 .4 31..6 31..3 31 .0 30 .5 30..2 30,.6 26 .0 34 .5 29 .8 31 .6 26..2 30. 8 28..8 29 ..0 30..7 27..7 30..8 31.,3 25..6 26..1 21..4 28 .3 27 ,.6 27..1 25 .4 29..2 32..5 30..7 30 .3 29 .6 29 .5 31..3 27 .2 27 .6 31 .9 31 .5 33 .7 32 .1 29 .2 35..5 30..6 26 .3 34 .1 28 .7 33 .1 25..3 30. 4 28. 1 28..0 30..7 8..5 32..6 30..7 25..6 24..6 26..6 27 .8 27 .1 30..9 26..3 26..5 31..9 32..8 29..0 30 .9 30..9 30..8 25 .0 26 .5 32 .4 31 .0 33..0 33 .7 31 .5 29..6 32..3 26..4 34 .4 27 .8 29 .7 :om pany S anitized D o not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 74 Day 77 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 25.7 32.1 28.2 28.5 28.8 30.6 29.8 23.5 22.8 30.4 35.5 32.3 29.5 29.6 34.6 20.8 28.5 29,1 30.6 26.4 23.3 30.2 26.7 26.5 28.6 6.8 32.0 30.1 24.6 24.0 26.6 26.9 25.1 29.7 24.7 Day 84 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 90 Day 98 Day 105 Day 112 23.4 27.3 27.0 25.0 27.9 AX TEST DAY 77 16.9 24.6 24.5 24.9 27.1 20.0 25.1 31.4 24.8 23.6 27.8 25.8 25.7 29.7 26.8 19.5 23.7 22.5 28.1 2 0 .5 23.7 24.9 23.4 31.1 26.5 21.8 23.0 24.6 29.9 1.4 24.6 31.2 24.7 27.7 18.5 23.7 32.9 22.2 Day 119 22.5 28.9 20.5 31.0 24.7 Day 126 29.1 30.1 15.3 29.4 23.6 DuPont-5386 Day 133 27.1 29.8 28.4 24.6 26.6 Com pany Sanitized. Does not contain TSCA CBI 612 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 140 Day 147 Male, V - 100 mg/kg/day 643250 643243 643311 643318 643247 643175 643314 643275 643257 643224 643169 643159 643286 643181 643206 643313 643182 643146 643312 643199 643267 643216 643244 643245 643301 643200 643255 643157 643238 643227 643164 643154 643156 643208 643190 27.7 13.7 32.5 33.5 26.7 30.6 32.3 31.4 36.3 28.1 Day 154 30.3 33.8 30.0 35.0 26.9 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 Day 168 Day 175 Day 181 29.6 32.5 28.0 36.4 27.8 30.3 32.2 27.6 40.3 27.8 28.0 30.3 30.0 37.8 27.2 24.2 27.5 26.4 32.1 24.7 DuPont-5386 Company Sanitized. Does not contain TSCA CBI 613 )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 26..4 25..9 25,,4 23 .6 26..6 26..6 26..7 28 .3 25..1 30..8 23 .8 24 ,.9 23 .1 29 .0 24 .2 23 .4 30..7 29..5 25..8 25..6 32 .5 27..7 25..0 25..2 26..4 24 .7 28 ,.4 28 .3 28..0 26..4 26,. 1 29..2 24 ..7 25..9 27 ..5 29..8 24 ..7 24 ..7 25 .. 6 26..6 25 .4 28 .. 1 20 ., 9 35 ..7 20.. 5 25..1 27..5 26..0 24 .0 27..5 28..8 29..2 29,.8 27 .7 33 .0 26..3 28.,1 25..2 31..1 26.,7 25..8 33 .5 31..9 27..6 27 .7 34..6 27 .1 27..3 26..5 28..6 26..9 29 .7 27 .4 27 .7 28..6 29.. 1 32 . H 27 ..4 29 .6 29..3 31..3 28 ..6 29 ..2 29 .,7 28 ..4 29 .6 3 1 .. 6 22 .. 6 29..9 27.,7 Day 21 INDIVIDUAL FOOD CONSUMPTION Day 28 Day 35 Day 42 25. 6 26..6 25..4 24.,9 26..9 29..4 27.,3 28..7 28 .3 32 .3 24..8 26..9 24 ,.0 31..7 27..7 25..7 33..1 30,.5 24..9 30..5 33 .4 28..8 26..4 25..7 27..6 26..9 30..2 28 .4 29.,2 28..0 29..8 34 .. 7 27..7 29 .. 8 28.. 0 31.. 5 28..3 27 .. 8 27.. 5 29.. 1 27.. 9 30 .. 0 21.. 8 29 . 9 26..2 25..6 29..1 27 .2 27..5 28 .5 28..9 27 .,3 29 .5 29..2 32..4 25..6 30 .0 9..1 32..6 27 ,.8 26..8 33 .6 30..3 27..4 30..6 32..0 30..3 29..3 26 .3 27 .6 27 .0 29 .7 28 .8 30..0 26..3 30..6 34 ..2 27 .3 30,.7 29 .0 32 .4 27 ..6 28.. 9 26 . 6 29.. 8 28..7 31 .. 5 24..4 30 . 6 28..1 25..1 30..4 26..0 26..0 27 .7 27..6 27..5 29 .7 30 ,,2 34,.1 25 .3 31 .6 20 .7 33 .2 29 .5 27 .8 35 .5 31 .0 31 .5 31 .7 33 .2 31 .4 29 .5 28 .4 28 .4 29 .7 30 .2 29 .2 30 .6 27 .2 30 .3 33 . 5 26 .3 28 .8 29 . 2 31 . 0 27 . 2 28 .6 26 .0 27 .8 28 . 6 32 . _L 23 . 6 31 .3 28 .1 25..0 29. 0 26..8 26.,0 27..5 29..6 27 .1 30 .3 30..1 35..1 24 .0 32 .5 25..5 32 .9 29..7 27..6 34 .9 31..9 30.,7 28 ,.8 31..3 30,.7 28..5 26..8 28 .3 28 .0 31,.7 29..5 30..2 26..8 29.. 1 33 ..2 26..5 29..0 27 .3 29 . 5 12..7 27 ..6 25 .9 27..6 27 ..6 23 .. 7 22 ..4 28 . 8 28..1 614 (g/day) Day 49 24..8 19..3 22..6 21..1 23 .2 24..7 24..2 22 .8 23 .4 26..5 21 .6 28 .9 20 .8 32 .5 26,.9 25..6 29 .1 32 .4 28..2 29..0 29 .6 27 .0 27,.2 22..6 25 .9 26 .0 28 .0 28 .0 30 .7 27 .2 27..1 31 .8 25..8 26 .1 24 .7 30 .4 24 .5 27..5 24 .5 26 .4 19 .8 30 .0 23 .0 28 .8 26 .8 Day 56 27 .5 23 .9 24 .5 22 .8 26..4 9..9 28..0 26 .5 23 .1 31..0 24 .3 29..2 24.,5 31..3 12 .5 13 .6 32 .5 32..4 29..5 27 .4 18 .4 27 .6 26..8 29 .5 28..2 24,.7 27 .0 29..2 30 ,.1 25..2 27..3 29..1 25.,1 26..1 26 .2 30,.9 28 .0 28 .0 21..8 30 .0 23 ,.9 28 .7 23 .7 26..0 28..7 Day 63 27 .0 30. 2 25..2 26..4 25..3 23..2 27..9 29..3 22..6 33..4 19..9 23 .2 23 .4 27 .4 14..5 23 .5 31..6 29..2 25..3 17..4 28..9 15..8 24..9 21..0 22..9 24..3 19,.8 22 .5 28..3 25..8 27..5 26..2 19..1 20 .6 29 .8 28..3 27..1 27 .3 18..2 22 .2 21..3 27 .9 20 .7 16 .8 28..0 DuPont-5386 Day 70 29 .9 4 .0 25. 8 27 .5 13 .6 24. 7 27. 2 27 .4 30..0 31. 1 14 .7 27..4 24. 4 28..0 12 .2 28..0 12 .0 28..5 14..6 23..0 23..4 14.,0 20..8 28.,5 22 .2 24 .6 23 .6 27 .9 26,.3 26..0 26..4 5..2 6..4 6..4 29..1 4 .4 24..5 25 .4 19 .6 26 .9 28..1 26 .0 22 .0 12 .3 25 .8 om pany Saoffized. D oes not com eta TSCA CB. ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 74 Day 77 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 28.8 25.4 25.9 22.8 31.8 21.0 20.0 30.8 18.9 28.8 29.1 28.5 18.6 27.9 28.8 10.1 34.3 27.4 26.7 18.7 AX TEST DAY 70 27.8 25.3 31.6 15.5 13.5 27.6 27.7 23.2 26.7 16.9 36.4 25.3 37.4 26.2 30.2 11.6 25.6 26.9 22.3 10.4 23.8 13.9 28.0 27.3 Day 84 INDIVIDUAL FOOD CONSUMPTION Day 90 Day 98 Day 105 26.9 29.5 24.7 26.9 29.1 28.5 27.0 29.0 26.7 27.4 23.0 25.8 20.8 31.4 22.0 27.4 29.9 24.1 21.0 28.8 27.8 23.9 26.7 26.1 27.8 24.5 20.5 18.8 26.4 24.3 24.2 25.5 20.7 30.3 23.4 25.4 23.3 19.4 31.5 25.0 26.6 32.4 27.2 26.1 22.9 31.0 31.7 26.5 18.1 29.6 26.0 31.3 26.9 24.0 22.6 29.5 30.0 27.4 20.1 17.5 26.3 30.3 25.1 26.5 22.5 23.5 27.2 27.5 21.1 26.7 27.4 31.3 26.6 29.9 21.0 25.5 25.3 25.1 21.9 25.8 615 g/'day) 112 Day 119 Day 126 DuPont-5386 Day 133 18.9 24.0 19.6 31.7 23.9 20.5 24.7 19.5 32.4 22.9 23.1 26.2 20.7 31.5 24.2 23.0 27.3 21.3 32.0 25.4 26..7 30..5 23 .5 27..8 21 .6 27 .7 24 .8 25 .7 20 .4 23 .1 26..8 29..5 23 .7 27..3 24 .6 24 .6 26..7 27..8 23 .6 25 .8 Com pany Sanitized. Doas noi contain TSCA CBI ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) Day 140 Day 147 Male, VII - 250 mg/kg/day 643194 643252 643260 643315 643215 643193 643298 643201 643259 643174 643283 643149 643178 643152 643295 643289 643171 643158 643249 643161 643309 643248 643285 643278 643299 643274 643192 643222 643160 643191 643203 643282 643302 643317 643225 643296 643258 643316 643220 643236 643165 643266 643151 643234 643281 27.0 28.8 24.6 29.9 24.3 28.9 31.0 24.1 31.0 28.8 Day 154 30.5 30.5 24.6 32.4 29.4 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 Day 168 Day 175 Day 181 30.6 30.5 25.4 35.9 31.0 31.6 31.5 25.7 34.9 30.7 29.2 29.9 23.7 33.1 28.5 25.9 25.8 20.8 31.1 22.8 J DuPont-5386 company Sanitized. Does not contain TSCACB 616 I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Female, il - 0 mg/kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643 393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 18 .9 19..8 17 ,.0 14. 8 18. 3 18. 9 16..4 18.,7 18 .9 15 .9 15,.4 17 .5 17 ,.2 16..8 16..6 18 ,.7 17 .3 17 .7 20 .2 18..6 18 .5 17 .3 20 .0 17 .5 18..1 19 .8 22 .2 19..8 14..6 17 .7 21..2 20 7 18 ,.9 18..4 18..5 22 .0 20 .X 22..6 19 .i 21.,8 19..3 21 .4 18..8 19..2 18 .8 18 .5 19..6 17 .7 13 .4 18 .9 20..7 18..2 18 .9 19..8 16,.5 20 .5 17 .1 20..7 16 .9 19..0 20,.7 19..8 20..2 20 .6 21 .4 19..5 18..0 22..0 22..0 19 .4 22 .1 23 .4 22..7 17 .8 18 .8 23 .5 22..8 20..9 19..7 19 .1 24 .7 22..0 20 .9 19..9 24..0 22 .2 18 .7 21..6 19..9 18 .9 Day 21 INDIVIDUAL FOOD CONSUMPTION ay 28 Day 35 Day 42 19 .8 18 .3 17 .2 15..8 22 .3 21..0 18..0 18 .6 20 .5 18..4 19 .0 18 .9 20..2 17 .9 17..8 21..0 19 ,.5 18 .8 19..4 20 .8 20 .9 12 .8 20 .6 20 .7 18 .8 24 .7 24,.2 21 .8 16 .7 18 .9 22 .2 22 _5 19..5 18..9 17 .7 22 .9 21 .1 19 .6 20 .9 22..4 21 .4 19 .5 22..1 21 .2 19..8 18. 8 18..0 19 .0 14. 4 20. 1 20..8 18..1 22..3 19,.2 16 .7 20..3 16..6 19..2 15 .3 17 ,.7 20,,7 19..1 19 .4 18,.7 20..0 21..0 17..5 22..6 19 .3 17..4 22 .2 22 .3 19 ,.7 18..0 18..2 20 .6 24.,6 20 .3 16..5 17 .1 23 .9 21 .1 19..5 20 .2 24 .2 21..0 18 .8 22..2 22..4 19 .8 21..9 18 .5 19..1 15. 9 21..5 21..7 20..9 21..3 20..9 17 .8 22.,2 19..8 20 .3 17 ,.9 21 .4 22 .2 22 .3 21..5 21..0 21..7 22..9 18..6 22 .7 19..4 18..8 27 .6 25..7 22 .5 17..9 17 .7 22..3 23 .4 22 .0 17..4 17 .4 24 .7 19 .5 20 ,.7 22 .1 22 .1 21..8 21 .3 21..8 23 .4 21..2 20. 4 21. 9 18 .4 17. 0 19. 8 19. 9 18..2 18 .4 22 .,0 19 .4 23 .0 20 .,4 19..9 15 .6 17..1 20,.3 19 .8 22 ,.8 18 .7 19..7 21 .0 18..9 21..4 20 .0 20 .5 25 .9 24 .8 22 .5 16..9 18 .9 21 .3 22 .6 21 .8 17..6 17 .5 24 .7 21 .5 20..8 20..0 21..4 21..1 19 .3 21..1 23 .1 20 .3 617 I (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 18 ,5 18 .2 18..0 16..7 26..1 19..4 18..8 17 .6 19 .1 20..4 25 .2 22 ,.6 21..7 18..1 19 .3 21..1 21..1 22 .1 21..1 20 .7 2 0 ..9 18..8 21..9 21,.3 18..8 27 .2 24 .9 23 .3 19 ,.3 18..2 22 .6 22,,7 21..2 18 .4 18..5 24..1 20..2 19 .7 20..2 20,.7 20 .8 19.,2 21..2 24..0 20..3 18..8 20 .1 19..8 20..5 24..4 23..8 22..1 21..4 21..5 21,.2 23 .1 24..4 22 .0 16 .9 18 .8 20..0 20..5 19..6 17 .0 20 .7 21..9 20..5 24..7 19..1 20 .3 24 .2 23 .9 22 .7 19..9 18..0 20 .2 24..0 21..1 17..6 18.,5 24..0 20..6 22..5 20..6 21..6 20..5 19..6 20..0 23..5 21..7 20. 6 22 .4 20 .6 19 .2 24 .,9 22..7 21. 3 18..8 21..9 20 .9 20 .8 21..9 20..9 17 .2 19,.8 20 .3 16 .8 20..1 19 .8 20 .0 2 0 ..6 20..4 22 .8 19..0 19 .0 24..9 23 .3 23 .5 18 ,.2 19..2 21..9 22 .0 22 .,7 18..3 19..0 22.,0 21..3 23 .8 21..3 26.,3 21..0 19 ,.9 21..2 22 .,8 22 .8 18 .6 22..4 19..2 19 ,.5 24..5 21..5 21.,8 20.,7 21,.0 18..7 22..1 23 .6 22..3 18..5 18..9 20..0 19,.8 21..1 18 .7 20 .3 21..4 19..1 21..9 18..8 19..7 22 .2 21..2 23..1 18..3 18 .5 21 .3 23 .1 20..3 17..5 18..3 22 .8 20..8 20..0 22 .9 30..2 20..7 20 .3 22 .3 22..7 21..5 mpany Sanitized. Does not contain TS C A CPI I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 74 Day 77 Female, II - 0 mg/kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 23.4 19.2 21.4 19.0 23.3 22.5 19.8 22.1 23.2 20.5 24.4 24.5 23.9 21.1 19.4 24.5 23.3 23.5 19.8 19.2 17.7 24.2 18.6 16.6 25.0 23.1 23.2 21.0 21.0 20.2 20.5 25.5 20.9 19.0 19.5 20.8 20.8 20.7 21.5 27.8 18.7 19.2 18.7 22.3 21.7 Day 84 INDIVIDUAL FOOD CONSUMPTION Day 91 Day 98 Day 105 19.2 20.2 33.5 16.2 24.9 21.3 22.7 21.8 20.7 19.9 21.7 21.1 21.2 16.0 18.6 20.0 22.2 18.5 13.3 24.4 19.7 20.4 21.9 19.3 19.9 20.3 20.3 18.5 16.4 16.6 21.0 17.7 21.1 16.2 18.7 20.4 10.7 20.5 18.1 17.5 21.0 19.8 22.3 22.5 29.5 19.9 19.3 21.6 20.3 19.3 21.9 18.6 17.3 18.5 25.4 18.5 7.9 19.2 20.2 19.7 21.4 19.4 25.2 19.6 27.1 21.1 14.2 20.3 22.7 20.1 21.9 23.9 24.3 22.3 27.0 20.8 22.9 15.8 26.8 23.2 618 ) (g/day) Day 112 Day 119 Day 126 DuPont-5386 Day 133 21.0 18.9 17.5 17.3 18.4 20.8 19.9 16.5 17.2 15.9 21.0 21 .3 19.7 19.0 15.9 23.9 22.1 20.7 19.3 20.1 21.5 22.5 25.1 24.9 22.7 21.2 23.1 24.1 27.8 27.0 21.3 22.3 22.5 21.2 SE TEST DAY 105 22.5 20.9 22.6 25.0 jompany Sanitized. Does not contain TSCA CBI )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 140 Day 147 Female, II - 0 mg/kg/day 643477 643374 643406 643486 643361 643463 643398 643436 643362 643354 643402 643383 643465 643484 643384 643352 643343 643459 643394 643480 643319 643350 643363 643397 643421 643420 643419 643414 643401 643455 643378 643393 643447 643478 643386 643405 643425 643448 643426 643415 643453 643330 643336 643387 643377 21.9 23.1 18.9 17.9 18.9 23.2 23.7 21.9 20.7 19.8 Day 154 24.1 26.9 24.8 19.7 20.7 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 Day 168 Day 175 Day 181 25.3 27.1 23.6 23.0 21.9 23.2 27.8 22.8 19.8 19.0 22.0 22.2 21.9 18.7 19.6 21.3 19.3 20.6 15.7 18.7 ) DuPont-5386 Company Sanitized. Does not contain TSCACBI 619 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Female, IV - 25 mg/kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643483 643411 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 15.8 20.6 18.6 19.3 19.1 19.1 15.4 17.2 15.9 16.2 17.6 AK TEST DAY 0 19.0 17.1 16.0 16.8 15.5 18.7 17.2 18.4 20.0 18.0 21.9 16.9 22.2 18.6 18.1 17.6 21.2 18.8 22.9 17.7 17.3 17.7 39.0 16.4 22.0 23.1 20.0 18.4 18.1 14.7 17.8 16.3 17.9 17.1 20.1 18.3 17.4 20.2 17.4 19.0 18.7 20.3 21.7 18.9 22.0 17.5 18.7 20.1 19.6 18.3 23.2 21.4 19.9 20.1 17.3 19.0 39.6 Day 2 INDIVIDUAL, LOUD CONSUMPTION Day 28 Day 35 Day 42 18 0 23 6 21 2 23 8 18 9 21 5 18 4 19 17 46 18 7 17 9 21 7 18 8 18 7 19 9 18 8 19 6 18 7 20 9 20 2 20 7 23 6 ]7 5 22 5 22 0 21 7 19 0 24 0 23 5 19 5 21 3 18 9 19 9 40 0 17 .5 20..6 22 .3 23..2 17..9 21..0 17 .0 19..3 16.,8 18 .9 17..2 20..2 18,.5 17..9 19..9 18 .0 20.,6 21..1 21..3 21..4 22..5 24..6 19..4 22..2 21..8 18..2 17 .9 24..1 23 .2 20 .0 19 .7 18 .5 17 .9 39..9 18..6 20..4 23 .8 21..5 23 .1 22..0 22 .2 22..7 20..0 21.,7 21..5 22..8 SE TEST DAY 29 21..0 19 .9 19 .3 18..7 20.,8 20 .6 20,.1 19..0 20,,3 18 .3 18..8 21..7 19 .2 21..4 20..1 21..7 20..9 20 .9 28..4 20..1 21,.7 20..7 19..2 18..3 22 .2 22..7 21..0 20,.2 19..2 18 .0 37..4 20..5 21..2 18..9 20..2 18 ,.4 22..2 17 .8 22..0 22 .1 23 ,.3 27 .8 19..8 22 .8 21..1 20..9 18..3 22 .9 21 .5 22..7 20..9 19..1 18 .4 36..7 (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 19..5 20..4 23 .0 19..7 19,.3 21..7 21..7 18.,0 18..0 19..6 22 .0 19 .6 18..1 20 ..5 17..6 20..2 21.,9 21.,4 20..9 19..3 26..1 20..7 24..7 22..0 22 .5 18..5 24..2 21..8 23. 1 8..3 20 ..1 18. 2 38..6 20 .0 23 .3 25..7 22 .5 12 .,6 21..6 20..7 23 .6 19,.8 19..1 20 .7 19..7 26..0 19..9 18 .4 19..8 18 .5 20..0 21..5 18 .1 23 .3 17 ,.7 23 .,9 22 .1 20 .0 18..6 24 ,.3 21..1 19 .2 22 .9 19..9 18 .6 38..3 21..0 23 .7 23 ..4. 21..7 17 .7 21..7 21..1 20,.7 21 .3 20 .5 22..0 20..4 19.,6 18..8 18..7 20,.3 19..0 20..3 21 .8 18 .1 22 .6 19 .5 24..7 23 .7 18 .9 18..0 23 .0 22..4 21..9 21,.1 20..9 19.,7 20 .3 20. 2 28..7 24. 2 21..9 20..5 20..4 21..3 21..4 20..9 18..9 20.,9 20..1 19..3 20..5 17 .3 17..5 19..8 19..6 20 .7 19..2 21..6 18..2 23..5 20..7 18..3 16..6 22 .2 20 .9 20.,4 20..3 18 .0 18..6 18..5 Company Sanitized. Does not contain TSCA CB i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Female, IV 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643411 643483 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 ' 74 Day 77 25 mg/kg/day 20.5 28.5 22.6 21.2 18.6 21.1 22.1 21.5 20.3 21.1 19.8 19.6 21.0 21.0 23.0 18.4 21.9 20.3 24.9 25.5 8.8 19.8 25.9 22.6 26.8 22.5 21.9 21.5 20.0 17.9 19.1 19.7 18.1 Day 84 20.0 29.1 24.4 21.6 16.4 20.4 21.6 19.6 20.3 19.5 18.9 20.0 18.5 INDIVIDUAL FOOD CONSUMPTION (g/'day) Day 91 Day 98 Day 105 Day 112 17.0 23.8 21.5 20.0 16.0 18.8 19.8 21.6 18.3 18.2 17.7 18.6 15.6 18.7 21.4 18.5 17.5 18.6 21.2 20.6 19.7 19.0 22.5 21.5 19.9 Day 119 19.8 22.0 20.9 18.8 Day 126 19.8 22.5 21.7 18.5 DuPont-5386 Day 133 18.7 22.7 20.9 19.3 Company Sanitized. Does not contain TSCA CBr I) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) Day 140 Day 147 Female, IV - 25 mg/kg/day 643390 643396 643380 643433 643389 643410 643321 643324 643458 643364 643411 643483 643379 643391 643437 643399 643334 643464 643369 643490 643342 643438 643445 643418 643325 643479 643403 643376 643422 643452 643475 643372 643400 643395 643457 20.0 23.4 22.5 22.1 22.5 24.0 21.2 21.2 Day 154 22.2 24.4 23.6 22.1 Day 161 20.9 23.7 20.6 20.0 Day 168 20.8 23.6 22.0 20.5 Day 175 21.2 23.9 21.6 17.7 Day 181 16.7 20.3 18.4 17.4 DuPont-5386 Jsmpany Sanitized. Does not contain TSCA CBI 622 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 r'ema1e , Vi - 100 mg /kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 18.,6 17,.5 16 .1 18 .9 18 .5 21..7 17 .7 13 .5 16 .4 16,.9 17 ,.1 16 .0 17 ,.4 15.,1 17 .7 18,.3 18,.6 20..4 17 .8 17 ,.8 17..0 17..9 1 8 ..1 2 1 ..5 17..9 17 .7 17 ,.8 17 .1 18 .5 18 .0 17 .9 18 .0 20 .3 18..6 19 ,.7 18 .9 16..7 17 ,.4 19.,1 19. 5 21..7 18.,9 15..5 16..1 18..1 18..6 16 ,5 17 .4 16.>i 17.,2 19..1 20 .0 21..5 19..4 18..5 18 .9 19..5 17..3 20..9 19..9 19,.9 16..7 17 ,.0 18..3 20..0 17 .7 18..5 19..6 18..1 19..7 Day 21 19. 1 18. 9 17 .8 20..0 20. 9 22 .2 19 .3 16 .0 16..7 19 .8 20 .5 19 .8 19 ,.5 17..7 20..5 21.,2 22..7 20 .2 19 .9 19..3 19..7 19..0 19..3 22..9 21..3 23 .,7 17 .9 18 .4 20..2 20..4 19 .6 ^o 4 20. 6 19..8 20 .7 INDIVIDUAL FOOD CONSUMPTION Day 28 Day 35 Day 42 19 .7 17 .5 17 .1 21..6 21.,9 22 .3 19..5 17 .4 18 .1 21..3 19..3 6 .6 19 . 16..8 21..5 23 .0 21 .2 22 .3 19..3 19..7 18 .3 21 .6 19..4 24..3 22 .2 22 .2 20 .1 18 .7 19 .9 21 .0 19 .1 21..4 20..4 18 .2 20 .9 19.,6 19 ..0 18..9 21,,8 19..4 23 ..1 1.7..9 17 ,.2 16,.6 19.,1 18.,0 9 .7 18 .8 15..8 20..2 22..2 19..9 22 .8 18 .2 21..3 19..2 21 .2 18..6 18,.2 19..8 21 .7 18..1 19..5 20..3 20 .7 19..4 19..8 20..6 18,.9 21..2 17. 9 17. 4 16 .,7 21..8 18. 8 20 .2 18..1 17 .4 17..6 20 .1 17..0 10..5 18..5 17..6 19. 21..7 20..1 20 .3 19..3 20..0 18,.5 20..3 19..3 7 .0 19 .2 19..1 19..l 18 ,6 18 .7 19,.9 18..3 19 .0 21..4 17 .2 19 .8 (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 16..3 2 1 ..4 18 .1 19..8 18.,6 16..5 17..0 14 ..6 16..5 17 .9 18 ,9 17 ,1 18 .9 19..9 2 1 ,,8 2 2 ..2 19 ..8 2 1 ..6 19 .5 2 2 .9 19.. 8 2 1 .7 19.. 2 25..2 2 1 .0 23 .4 20 .6 2 0 ..2 19..5 2 1 .9 22 .0 2 1 :6 24 .1 19.. 0 22 .7 19..3 2 2 .,7 17 .4 2 1 .9 2 2 ,.5 2 1 .9 18 .9 16..9 19 .0 2 1 .0 2 1 .1 22 .7 19 .1 18..7 19..3 23 .3 20 .7 2 0 .0 18.. 8 21 .1 19 .3 21 .6 19 .1 19 .9 21 .2 24 .2 20 .2 20 .9 19 .7 20 .3 19 .8 20 .2 23 .4 19 .3 21 .1 2 0 .,3 2 0 .6 19.,4 2 1 ..8 19.. 8 2 0 .4 19.. 6 17 ..0 18 .2 2 0 .8 2 0 .5 12 .1 17.. 2 16.. 2 2 1 .3 2 0 .5 18 .7 20 .2 18 .0 21 .1 18 .0 23 .4 18.. 0 22 .4 18 .9 20 .8 18 .1 2 0 ..2 18 .0 22 .4 17 .6 19 .8 21 .2 20 .0 20 .7 18. 0 23. 2 18. 9 2 2 ..0 2 0 .3 16..1 19..2 17 ,.5 18..0 2 1 ..8 2 0 .6 2 1 ..0 18..0 19..7 2 0 .4 2 1 .9 19..5 19.. 8 17 ..1 2 1 .5 19.. 6 2 1 .4 18.. 8 24..5 18..5 2 0 ..8 17..4 19.. 6 18..4 21 .8 17 .4 19..0 2 2 .5 19 .7 19 .4 Jompan, t a t o * Dm s ,, olcon|a|n TSCA cM H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 74 Day 77 Female, VI - 100 mg/kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2 1 .0 20.9 18.9 17.6 2 1 .2 2 1 .1 23.8 19.2 9.8 19.1 22.3 2 0 .5 2 1 .2 19.2 24.2 21.4 20.3 2 2 .2 2 0 .2 2 0 .9 18 5 20 5 18 6 22 7 19 6 18 4 17 2 17 8 17 4 20 1 20 8 16 5 19 5 16 9 23 9 Day 84 18.2 19.1 17.3 20.5 21.5 15.5 18.9 17.4 17.3 19.8 2 2 .2 17.9 19.9 17.7 20.4 INDIVIDUAL FOOD CONSUMPTION (g/dayj Day 91 CCTOi Day 105 Day 112 16.6 20.9 16.7 19.3 2 1 .0 18.8 17.9 14.5 15.3 15.4 17.1 15.7 17.6 15.0 18.1 17.7 18.2 17.0 14.2 18.1 19.3 15.3 19.5 17.8 19.3 20.9 16.4 2 0 .2 1 0 .1 2 1 .8 Day 119 20.9 7.4 2 0 .6 15.5 20.3 Day 126 2 0 .1 23.4 19.5 16.8 23.2 DuPont-5386 Day 133 19.2 19.0 2 2 .5 18.2 2 2 .6 Company S a n itize d . Does noi contain TSCACBf 624 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 140 Day 147 Female, VI - 100 mg/kg/day 643322 643489 643409 643366 643367 643461 643462 643392 643472 643323 643412 643382 643381 643360 643373 643320 643488 643428 643439 643353 643385 643339 643473 643337 643416 643407 643357 643331 643427 643470 643434 643349 643454 643333 643460 2 2 .6 30.7 2 0 .0 18.5 2 2 .2 22.4 29.3 23.0 2 1 .0 26.6 Day 154 2 1 .0 18.4 23.6 20.4 23.2 INDIVIDUAL FOOD CONSUMPTION (g/'day) Day 161 Day 168 Day 175 Day 181 2 2 .9 25.6 21.3 18.4 24.9 2 2 .8 20.5 2 1 .1 18.0 24.2 21.7 18.0 20.7 18.8 25.8 18.4 32.5 19.0 19.2 23.7 DuPont-5386 L ompany Sanitized. Does not contain TSCACBI 625 )) H-24516: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Day 7 Day 14 Female, VIll - 250 mg/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 17 .5 2 1 .3 17 .7 16..7 15..8 15..8 15.. 6 18 .1 16,.7 16..7 16..3 16 .8 17 ..6 15 .4 19 .7 20 .0 15..1 19..9 17 .3 18 .2 18..9 17.. 2 19 .6 1.6 .5 18..5 18.. 0 19..0 22 .3 2 1 .4 2 0 .8 17..2 18 .4 19..3 17..9 37.. 6 16 .0 20 .9 17 .1 19..2 14..9 18..6 17 ,.9 16..7 20 .1 17..9 18..2 2 2 ,,6 19..1 2 0 ..0 16..9 18 .3 17 ,.9 2 0 .4 19 ..0 19 .7 17..0 18 .2 18 .5 2 0 .9 18.. 2 23 .3 2 1 ..2 2 1 .1 18..9 18.. 6 2 0 .0 19.. 0 2 1 .3 19.. 0 19.. 2 18 .4 19..4 23 .3 2 2 .5 19..8 18..2 18 .8 2 2 .0 19..7 18 .9 17..7 20 .9 17 .6 18 ..8 18..3 18 .5 18 .5 17 .4 19 .2 18 .0 Day 21 19,.0 25,.9 2 0 .3 19 ..1 19 .1 18..1 18..3 2 0 .3 19.. 0 19 ,.3 17.. 8 19 .0 18 .1 19.. 6 23 .2 20 .6 17.. 0 2 0 .4 19 .5 19 .6 2 2 ,.5 22 .3 25,.4 22 .0 2 1 ..6 19 .7 22 .4 26 .2 23 .9 2 2 .4 2 2 .1 2 2 .0 24 .4 2 1 .9 2 1 .4 IS .2 23 .3 17 .8 21 .6 19 .4 22 .1 2 1 .5 17 .8 20 .9 2 1 .5 INDIVIDUAL FOOD CONSUMPTION Day 28 Day 35 Day 42 17.6 23.3 19.5 17.7 20.4 17.9 2 0 .0 20.4 21.4 20.3 17.9 18.5 2 0 .1 19.9 21.5 21.5 17.8 2 0 .6 19.7 19.2 2 1 .8 19.0 2 1 .2 19.4 19.4 2 0 .2 2 0 .8 26.8 25.7 21.9 20.4 18.7 23.0 20.5 17.9 17.3 2 0 .5 18.4 18.5 18.5 19.4 2 0 .6 16.4 18.6 18.7 18.9 24.3 19.2 17.2 19.2 20.3 20.5 19.9 20.9 2 1 .6 17.7 17.8 22.3 19.6 23.3 2 2 .9 18.6 19.7 19.6 19.5 23.2 19.3 2 2 .1 2 0 .6 21.5 19.0 2 1 .6 26.6 25.1 24.2 20.5 20.3 22.9 2 1 .8 2 1 .1 17.9 2 2 .9 17.7 2 0 .2 18.2 18.4 2 1 .2 17.8 19.7 19.3 18.0 23.8 17.4 18.2 2 0 .1 18.8 17.9 20.7 18.7 19.8 17.4 14.9 22.4 19.7 2 1 .6 22.7 16.6 20.4 18.7 19.3 2 1 .6 17.9 2 0 .2 18.8 2 2 .1 19.1 19.2 24.2 24.6 2 0 .1 19.5 18.4 2 0 .1 20.4 18.7 16.7 2 1 .0 16.5 20.7 16.2 17.7 22.5 17.5 2 0 .2 19.9 626 (g/day) Day 49 Day 56 Day 63 DuPont-5386 Day 70 17 ..6 23..1 17 .7 16.. 6 17 .4 15..3 16..8 2 0 ,.3 2 0 .0 2 1 .3 16..1 17 .2 23 ..6 14 .5 2 1 .3 2 1 ..0 18..3 2 1 ..6 2 0 .3 2 0 .3 2 2 .5 19.. 2 19.. 8 20 .8 2 2 ..0 1 0 ..2 19..1 25 .8 2 2 ,.7 2 1 ..6 18..4 2 0 ..2 2 1 .4 2 0 .5 22 .2 18 .4 15 .6 6 ..8 16..9 18 .1 18 .9 2 2 .9 17 .3 19 .8 19 .0 18. 5 19. 0 2 0 ..6 15. 8 2 1 ..0 19. 0 17.,5 18.,1 2 1 ..3 19. 8 17..3 15..2 2 1 ..6 19.,7 19..3 15..7 2 1 ..5 2 2 .3 24 ,.5 12 .4 18,.7 15..8 19..5 32..8 2 0 ,.2 2 2 .4 2 .5 19..4 23.. 8 2 1 ,.6 2 1 .3 15..4 18.. 2 16.. 2 2 2 .7 17 .7 20 .1 19 .1 21 .1 19 .1 23 ..2 19..0 17 .3 14.. 6 16 .1 6 .4 21 .5 18 .4 2 2 ,.8 19..9 AK TEST DAY 53 19 .8 12 ..8 26 .8 25 .7 24 .6 2 1 .9 17,. 0 13 .3 19..3 1 2 ..6 2 2 ..2 2 1 .4 22 .0 18 .9 19.. 2 18 ..8 21 .0 19 .8 18 .9 18 .0 7 .3 2 1 .9 1 2 .3 2 0 .5 1 1 .4 19 .5 17 .5 10 .3 18 .8 21 .2 24 .7 1 1 .4 18 .9 17 .6 16 .1 10 .5 19 .4 18 .5 18.7 1 1 .0 18.7 17.2 18.5 19.6 18.9 19.2 21.3 FD TEST 1 2 .6 18.6 20.9 17.0 2 1 .0 9.7 14.7 15.4 18.5 18.1 13.0 1 .8 1.9 1 0 .2 1 2 .1 26.8 24.7 19.4 17.7 18.9 19.5 18.0 1 0 .0 15.4 17.1 25.8 16.6 17.3 2 1 .8 17.9 9.7 16.8 16.4 19.4 e itpany Sanitized. Does no! contain TSCA CB! )) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____ Day 74 Day 77 Female, VIII - 250 ir.g/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 6.8 9.5 18.2 20.6 20.0 16.3 25.5 28.3 22.6 40.1 52.1 26.2 14.4 13.1 8.4 21.0 18.2 20.6 4.0 15.8 15.4 17.8 17.4 16.3 16.2 14.8 18.9 23.6 1 2 .9 15.5 1 0 .6 16.8 5.1 19 .i 2 0 .3 12 .2 17..7 2 0 .9 19..1 17 .4 13 .4 26 .3 14 .8 Day 84 2 1 .6 29.2 2 0 .1 16.9 19.8 24.6 25.3 2 2 .9 23.4 19.7 2 2 .1 23.1 2 0 .9 24.3 2 1 .4 24 .2 23 .3 23 .3 17 .3 22 .1 29 .2 21 .3 25 .3 2 1 .3 INDIVIDUAL nOOd CONSUMPTION Day 91 Day 98 Day 105 18.4 25.7 14.0 14.1 16.9 18.5 15.5 18.9 24.4 16.6 17.7 20.4 17.1 24.3 16.9 15.6 19.9 17.6 26.9 17.0 14.8 2 1 .1 17.1 27.2 18 .1 18 .1 18 .0 18..0 16..1 2 0 .7 20 .2 16 .8 23 .4 18 .1 24..7 19 .1 18..3 2 0 .7 16..4 2 1 ..0 16 .7 16 .8 24 .3 2 0 .4 24 ..2 18 .7 18 .5 2 1 .4 18 .8 23 .1 20 .0 16 .4 26 .2 20 .4 627 ) (y/duy) Day 112 Day 119 Day 126 DuPont-5386 Day 133 16.8 14.8 17.4 2 0 .1 25.8 16.9 16.4 18.6 18.5 24.0 16.2 17.4 18.0 18.2 22.9 15.8 19.6 18.9 16.4 2 1 .0 20.4 17.6 18.3 20.9 17.8 2 0 .1 18.3 16.9 2 2 .1 19.2 1 2 .1 19.1 19.0 22.9 17.3 23.0 2 1 .0 17.3 22.3 2 0 .2 Company Sanitized. Does not contain TSCA CBI )}) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________________________________________________ DuPont-5386 Day 140 Day 147 Female, VIII - 250 mg/kg/day 643341 643370 643446 643435 643466 643332 643404 643408 643359 643340 643487 643356 643329 643388 643450 643467 643443 643417 643413 643338 643335 643468 643440 643430 643431 643368 643326 643365 643375 643328 643348 643346 643449 643429 643424 643347 643456 643423 643345 643351 643358 643444 643474 643441 643481 17,4 24.5 17.1 2 1 .6 21.3 19.7 25.2 19.9 2 2 .8 23.7 Day 154 21.3 25.7 21.5 2 0 .1 26.0 INDIVIDUAL FOOD CONSUMPTION (g/day) Day 161 Day 168 Day 175 Day 181 2 0 .1 26.5 2 1 .1 21.3 23.8 20.4 22.4 2 2 .6 20.9 24.9 19.5 18.4 22.7 19.3 23.3 19.0 19.4 18.5 18.3 2 2 .0 Company Sanitized. Does not contain TSCCBI 628