Document RpMQx38Ng90xMxpJZpEX2wpYv

AR226-2841 vy Copies toil Haskell L a b ! cLoLryf froro Troxi"co^log*y !anfd 4IndCTMustpr"ia>'l Medicine HASKELL LABORATORY REPORT NO. 372-73 """ L Procedure: ChR-CD male analysis. Th*. f-Qcf- material, as rats in single doses. an aqueous Survivors ACUTE ORAL TEST Results: Dose lmg/kg)tr 3,400 2,250 1,500 1,000 670 450 Solution -- .( W 15 15 15 15 15 15 Mortality** D - 5 d. D - 4 d. D - 8 d. S - 14 d. S - 14 d. S - 14 d. Liver 22.46 19.16 19.22 Liver Wt. Body Wt. x 100 7.41 5.74 6.82 -------------- - Signs _______ S v'hof Lacrimation and salivation on rufflfd f 08 " 2`25Sm8/kg; lethargy, hromnH Ur* r<*-t*n6e`l nose and mouth, f 5oS ^ / v yrre\ and W6t Peri ^ l area at death 8/kg a"d above; eight loss until Nonlethal Doses: Lethargy from 3-4 days f 670 "8/k* *" above; ruffled fur from 2-4 days after dosing at 1,000 mg/kg; weight loss from 1-3 days, ALD 1 ,5 0 0 mg /kgIF i f ys; *?="> t - I Z frittnicce^d ( ) days after dosing. Based on product as received. Company Sanitized. Does not contain TSCA CBI * 2- - sl*ghtly toxic when administered orally to young adult ChR-CD male rats in single doses- its Approximate LethaTbose (AID) is 1,500 mg/kg of body weight. The compound produced liver enlargement in animals which were dosed at 450 mg/kg and above and which were sacrificed after 14 days. NCD:dhg Date : August 21, 1973 Report No. 372-73 Report by: Approved by: '( / Nancy C. Dale Oral Toxicology Section Jr. ^Director t Company Sanitized. Does net contain TSC CSi