Document RakO854z7mqQRBGLmNK0v5BEE

k- nu-Q6) 33 Ti 0 CO CO CO 00 O) Ol (GTF'ZAB) TRANS. HID. NO. 11i985 (1980) NTC. NO. GIGIENA TRUDA I PROFESSIONAL'NYE ZABOLEUANIIA. V* (5)28-32 (1930) Time course of the heart rate end dalvanic skin reflex during nidht sleep in patients with chronic occupational intoxication hy vinyl chloride* AUTHOR! Gnesina? E A TRANSLATOR: Livak date: July 1930 REQUESTED BY: D. Wrohleuski> 1803 TRANSLATION NO.: 80-7-32 R&S 133867 i //, ci?r w GO cq 50-7-32 r r Gigiena Truda i Professional' nye Zabolevaniia 1980, No. 5t 39-^2 TIME COURSE OF TEE HEART RATE AND GALVANIC SKIN REFLEX DURING NIGHT SLEEP IN PATIENTS WITH CHRONIC OCCUPATIONAL INTOXICATION BY VINYL CHLORIDE E. A. Gnesina and A. I.' Pshenitsyna 39 During various stages of sleep the heart rate (HR) and galvanic skin reflex (GSR), like other vegetative functions, undergo a number of regular changes (A. M. Vein). Thus, in the superficial stages of slow-wave sleep (SS) the HR, when compared with this index during the waking stage, decreases and disordered GSR appear*, in the deep stages of SS the HR increases and the GSR reach their maximum expression (L. P. Latash and coworkers; Coccagna and coworkers). Yvith the start of fast-wave sleep (FS) the pulse becomes more frequent and arrhythmic and extrasystoles arise. Here a variable rhythm is more characteristic for the FS than an increase in the HR; the GSR are usually absent in FS. It is usually assumed that the HR and GSR reflect the state of the emotional sphere (Bloch). From this standpoint the lability of the HR and FS correlates with experiencing emotionally colored dreams in this stage, but the greatest expression of the GSR in the deep stages of SS, or specifically delta sleep CDS), in the absence of dreams, represents a certain paradox. A study of the dynamics of the GSR during sleep disclosed that the maximum number of GSR is observed in the second and third cycles of DS, decreasing toward the end of the night, where the emotional nature of the dreams usually increases (V. P. Danilin /7 and L* P. Latash; V. 5. Rotenberg and coworkars). These data enabled L P Lataah to express the theory that DS, and the GSR accompanying it, has a damping role as regards the frequency and emotional nature of the dreams in subsequent episodes of FS. From the standpoint of the information theories (Gaardner), sleep represents a process that is characterized by continuous psychic activity, which proceeds either consciously, as dreams in FS, or unconsciously, as dreams in SS. In the opinion of L. P. Latash, the GSR are the stigma of the unconscious activity in SS. L. P, latash explains the practical absence of GSR in FS by the vegetative blockade mechanism, by analogy with the decrease in the muscle tone in this stage. Despite the fact that the presented data require further experimental and clinical confirmation, they can serve as a starting point when studying vegetative regulation in patients with sleep disturbances. '.Ve studied the HR and, GSR during the night sleep of patients with insomnia, which accompanies chronic occupational intoxication by vinyl chloride (VC.), a volatile narcotic that is widely used at the present time by the chemical industry in the production of synthetic polymers (E. A. Gnesina and V. A. Antonyuzhenko). Clinically, the intoxication is distinguished as two stages: the early stage, which proceeds with functionally dynamic shifts in the nervous system, and the later stage, where organic symptoms of damage to the trunk sections of the brain and trunk-hypothalamic paroxysms appear (V. A. Antonyuzhenko). We studied a total of 20 patients (9 in the early stage of intoxication, and 11 in the later stage), ranging in age from 30 to 50 years, and 5 healthy persons of the same age (control). The overall clinical tudy included a continuous polygraphic recording of night sleep by 133868 39 \ ^0 R&S 133869 the standard Rechtschaffen - Kales method, with recording of the EKG and GSR from a palmar surface by the I. R. Tarkhanov method. The stages of sleep were determined visually using the classification of the same authors. The HR in the episodes of the separate stages were calculated from the average Indices of the number of R*-R intervals on the EKG in three 20-second sections taken from the portions of the recording without motive artifacts. The difference between the maximum and minimum values of the HR in this stage was taken as the lability index in the FS. The absolute number and frequency of the GSR per minute in all of the episodes of the various stages of sleep were calculated during the entire polygraphic recording. The obtained data were processed statistically using the Wilcoxon - Mann - Whitney nonparametric criterion (E. V. Gubler and A. A. Genkin). The dynamics of the GSR and HR were compared with the answers of the patients regarding dreams during the time of the experimental night. The absolute number of GSR varied widely for the persons in the control group, and on the average was 1578. The frequency of the GSR in the first cycle predominated in the superficial stages of the SS (I, II), decreased toward the end of the cycle in the DS, and even more so in the SS; on the whole, the frequency of the GSR in the first cycle was lower than in the subsequent 3-^ cycles (Fig. 1). Beginning with the second cycle, a definite regularity appeared in the distribution of the GSR: the lowest indices ware observed in the superficial stages of the SS of all of the cycles, the highest ware observed in DS, while the transition from DS to FS was accompanied by a sharp drop in the frequency of the GSR. The frequency of the GSR in DS continued to R&S 133870 Fig. 1. Distribution of GSR during night sleep. Ordinate) frequency (number per minute) of GSR; abscissa) stage of slow-wave sleep (SS); FS) phase of fast sleep; A) line connecting average indices of GSR frequency in SS (I, II, III, and IV stages) and FS for persons in control group; 3) the same for the patients in the early stage of chronic occupational intoxication by vinyl chloride; C) in the later stage of intoxication. Fig. 2. Dynamics of HR during night sleep. Ordinate) ER (number of R--R intervals on EKG per minute; abscissa) the same as in Fig. 1; A) line connecting average indices of HR in SS (I, II, III, and IV stages) and FS for persons in control group; 3) the same for patients in early stage of chronic occupational intoxication by vinyl chloride; C) in the later stage of intoxication. R&S 133871 40 Increase from the second to the fourth cycle, and then it decreased, although the character of the distribution of the GSR was retained in the and 6th cycles (see Fig. 1). The HR for the awake persons in the control group immediately before placing the electrodes was 68 per minute. The transition to sleep was accompanied by a decrease in the HR. In the first cycle the lowest HR (59) was observed in the superficial stages (I and II) of SS, while in the deep stages of SS and FS the HR increased somewhat. Like the GSR, the dynamics of the HR in the first cycle differed from the dynamics of the HR in the subsequent cycles (Fig. 2). Beginning with the second cycle a high HR was observed in stage I of SS; the HR was lower in stages II- IV of SS. The frequency of the rhythm of the heart contractions increased again on going to FS, while extrasystoles appeared in the individual persons. The lability in FS increased toward the end of night up to 10.3 number/sec, and on the average reaching 8.8 number/sec. The range in the fluctuations of the HR, the difference between the extremes during the time of recording all of the HR values, was 12.0, After waking, when compared with being awake before sleep, the HR was observed to drop to 10.5 number/sec. The results obtained in studying the healthy persons testified to the complex nultistep reorganization of the vegetative regulation during sleep, with a variable coupling of the vagal (decrease in HR and GSR) and sympathicotonic (increase in HR and GSR) effects, and depicting the reciprocal relationship that exists between the DS and GSR when night starts and the constantly increasing decrease in the frequency and emotional nature of the dreams in the premorning cycles. R&S 133872 For the patients in the early stage of intoxication the total number of GSR was IO76, which is somewhat lower than for the persons in the control group, but the differences in the distribution of the GSR did not reach the confidence level (P > 0.05). The GSR distribution by cycles was similar to the distribution in the control group: minimum values in PS, and maximum values in DS. The highest GSR frequency was reached in the DS of the fourth cycle. The difference in the GSR distribution from the control group was related to the structure characteristics of sleep, by a reduction in its duration and a decrease in the number of cycles down to 4, and less frequently to 5* Judging by the GSR distribution (see Fig. 1), cycles were absent in which a decrease in the frequency of the GSR in DS and the arising of FS, accompanied by remembered emotional dreamy, could be expected. For the patients in the early stage of intoxication the HR prior to sleep was higher (70) than for the persons in the control group. The same as in the control group, a retardation of the HR was observed on going to sleep, but it began more gradually (see Fig. 2). In contrast to the control group, a tendency for reduction in the HR in the 4th and 5th cycles was not observed. V.hen compared with the control group, the lability in FS (4.2 number/sec) was lower (P < 0.05). The differences between the HR before and after sleep (5.0 number/sec; P < 0.01) and the range in the fluctuations of the HR (8 number/sec; P <0.0l) were smaller than for the healthy persons. Dreams were mentioned by 6 of the 9 patients in the early stage of intoxication. However, 3 of them after waking could not remember the contents of the dreams. The description of the dreams was fragmentary, included details of the scene, but not the entire picture. From the 41 standpoint of the clearness and remembrance of the dreams as a reciprcal function of DS saturation the GSR is high, while the depiction of the GSR in 3S| which did not decrease up to the end of sleep, correlated with some impoverishment of the dream activity for the patients In the early stage of intoxication. It is obvious that a more uniform distribution of the HR, and a decrease in the lability of the HR in FS when compared with the control group, both reflected a decrease in the emotional nature of the dreams experienced by these patients during sleep. For the patients in the later stage of intoxication the absolute number of GSR in the polygrams was lower than for the control group and for the patients in the early stage, and on the average was 459*5 (P < 0.05). A definite distribution of the GSR by stages within the cycles was absent} when compared with the control group the GSR frequency in SS was lower (P <0.01), and higher in SS (P <0.05)4 a tendency to establish a GSR maximum in the DS of the third and fourth cycles, like for the patients in the early stage, was not observed (see Fig. 1). The starting HR prior to sleep for the patients in the later stage of intoxication was reduced to 58* "when compared with the control group, a reliable decrease was observed in the range of the HR fluctuations (5.5 number/sec; P < 0.05) and the lability of the EH in FS (5 number/sec} P < 0.01). Here the HR, after an initial retardation in the first cycle, tended to show a steady increase in subsequent cycles. To sum up, the ER after awaking exceeded the HR before sleep by 7-2 number/sec (P < 0*01). The dream activity for the patients in the later stage of intoxication was characterized by a scantiness, and the dreams were rare (for 4 of 11 patients) and simple in content. It must be assumed that in the later stage of intoxication one of the factors, present in the general R&S 133873 pathogenetic chain with an impoverishment of the dream activity, can be the low and monotonic, not differentiated by stages and cycles, depiction of the HR and GSR. As a result, an analysis of the distribution of the GSR and HR during sleep for patients with chronic occupational intoxication by VC disclosed characteristic differences in the distribution of the vegetative indices in different stages of intoxication. Based on our previously obtained data, the insomnia'syndrome, arising during chronic occupational intoxication by VC, is related to an enhancement of the physical activation shifts in the early stage of intoxication and a predominance of the tonic activation in the later stage (E. A. Gnesina and V. A. Antonyuzhenko). This gives reason to believe that the change in dream activity and the picture of the vegetative ornamentation of sleep for the patients studied by us reflects a nonoptimum course of the information processes and disturbance of the vegetative regulation on a background of the activation shifts. The results of our studies permit an approach to understanding the pathogenesis of the emotional and vegetative disturbances that accompany the insomnia syndrome during intoxication by VC, and also by other narcotic poisons, and, in addition, they give basis for solving the problem of the pathogenetically based therapy of these disturbances. SUMMARY 1. A change in the number and distribution of the HR and GSR during sleep is observed in the insomnia syndrome that accompanies chronic occupational intoxication by VC. 2. In the early stage of intoxication the differences in depicting R&S 133874 R&S 133875 42 the GSR in the DS episodes during the night are counterbalanced; the lability of the HR and FS is reduced. 3. In the later stage of intoxication the number of GSR decreases and a definite distribution of the GSR by phases and cycles disappears; the lability of the HR in FS is low, and the differences in the HR in SS and FS are smoothed out. LITERATURE CITED A/ Antonyuzhenko, V. A*, Zh. Nevropatol. i Psikhiatr., 1973, No. 3, 377-382. /2/ Vein, A. M. , Disturbances of Sleep and While Awake /in Russian/, Moscow (1974). /3/ Gnesina, E. A., and Antonyuzhenko, V. A*, in the book: All-Union Symposium on the Clinics, Diagnosis, and Curing Ailments of Chemical Etiology, Abstracts of Papers /in Russian/, Kiev (1977), pp 65- 67. /4/ Gubler, E. V, and Genkih, A. A., Application of Criteria of Nonparametric Statistics to Evaluate theDifferences of Two Groups of Observations in Medicobiological Studies /in Russian/, Moscow (1969)/5/ Danilin, V. P. , and Latash, L. P., Fiziol. Zh. SSSR, 1975, No. 3, 362 - 366. /6/ Latash, L. P., in the book: Physiology of Man and Animals /in Russian/, Moscow (1975), pp. 94- 152. /7/ Rotenberg, V. S., Kochubei, B. N., and Shakhnarovich, V. M. , Zh. Vyssh. Nervn. Deyat. , 1975, No. 4, 858 - 86l. /8/ Bloch, V., Ann. Psychol., 2^ 97 (1952). /9/ Coccagna, G., Mcscheu, R., Vela, A., et al., Rev. Nevral., 17, 491- 506 (1977). /10/ Gaardner, X. , Arch. Gen. Psychiat. , 14, 253 - 261 (1966). -1 /ll/ Rechtschaffen, A., and Kales, A. , A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages ox Human Subjects, Bethesda (1968). Translated by: John Livak Aug. 16, 1980 COAEPJKAHHE CONTENTS JIETABET A. A. K 35*JieTino Bmhkom noOexbt 1 LETAVET, A. A. On the 35th Anniversary of the Great Victory EAEAEB A. E. TitrneHa Tpyaa npn CTpoitTtibCTBe HypeKCKoft I"3C 3 BABAEV, A. B. Industrial hygiene during the construction of the Nurekskaya Hydroelectric Station :VBOPOB C. B.. THXOBA T. C.. nOJIHKO- BA B. A.. UBETKOBA H. H.. ' FIAUJHHHHA O. M,, BOTATblPEB n. H.. KPAKOnA A. C,, BOPOHOBHUKAJf JL A. K nonpocy o aAOpoabe MemmuHCKtix cecrep c tohkh apcHHR riiriicmJ rpyjta ii npocpeccitoHa.ibHOH naTo.iorim 6 SUVOROV. S. V., TIKHOVA. T. S,, POLIA KOVA. V. A., TSVETKOVA. I. N,, PASHININA. O. M., BOGATYREV. P, I, KRAKOPA, A. S,, VORONOVITSKAYA, L. A On the occupational health of nurses CyBOPOB T. A- KOCCOBCKHH H. H., fJJEFIMAH Jl. C.. MHKiMHHCKHn A. M. K liopMiipOB3Hmo -lOKa.ibHofl B6pauHir Bbtco- KOMac-roTHoro ananaaona 10 SUVOROV. G. A.. KOSSOVSKY, N. N.. SHEIMAN. L. S.. MIKULINSKY. A. M. On standards for local high-frequency vibration MEHHFIJIO H. H.. TPHUEHKO B. C,, TETMAHEU. A. A., CHPQTA H. <t>. d>H3iio;ioroaproHOMHHecKoe oOocHOBaHHe MHHitManbHofi BbicOTbi pa6onero npocTpaHCTBa noA MexaHitanpoBaiiHow xpenbio 14 MENIAILO. N. I.. GRITSENKO. V. S. GETMANETS. A. A.. SIROTA. N. F. Proposed minimal height of the working space under mechanized timbering in mines CHJlAHTbEB B. B. K oueHxe btuihhhh th- HtccTit Tpyaa Ha nmcKonorHHecKyio 3a6o.3eBa- CMOCTb 17 1 SILANTIEV, V. V. Mathematical modeling in the evaluation of the effect of work intensity on gynecologic morbidity ilOMHHH C I\, APOHOBA T. B,, OOMHHA A. C. O Mcxamt3Me noBpewaaiomero AeiiCTBHH COCAHHCHHH ajUOMHHHH 20 DOMNIN. S. G,, ARONOVA, G. V.. FOMI NA, A. S. On the mechanism of injurious acti on of aluminum compounds APOHOBA T. B.. EOPOflyJlHHA C H.. KAUHE/IbCOH E. A., nOCTOBCKHPI H. H. O CBH3H xiiMimecKoro crpoeHHH h npOTHaocit.ItlKOTMMeCKHX CBOHCTB B pHfly *teTUpex3a.MeUlCHHUX aMIIH03l|)l!p0B nOJIHMeTaKpHAOBOH Kiic.ioTU (K Bonpocy o bo3mojkhocth Hanpas.lemioro CIlHTe33 npOTHBOCHAHKOTHHeCKIIX no.iHMepoa) 23 ARONOVA. G. V.. BORODULINA. S. N.. KATSNELSON, B. A., POSTOVSKY. I. Ya. On the relationship of chemical structure to antisilicotic properties in the series of tetrasubstituied amino esters of polymethacrylic acid (On the possibility of directed synthesis of antisilicotic compounds) EAEyUIKHHA Jl. I\. BEJIHHKOB- CKHn E. T. Po.ib numiAOB b MexaKHaMe rn- Oe.au KOHitotparOB 25 BABUSHKINA, L. G.. VELICHKOVSKY. B. T. Role of lipids in the mechanism of co- niophage death CAHOUKHn H. B.. JfABTHH P. M.. TJiy- | 28 SANOTSKY, I. V.. DAVTIAN, R. M.. GLU- LUEHKO B. H. HayneHiie MyntcKoit penpo-. SHCHENKO, V. I. Study of the reproductive ayKTiiBiiOM cfiyiiKUHH npii AeflCTSHii HexoTo- function in men exposed to chemicals pux xnMimecKHX BetuecTB u HA3APET3H P. A.. BAEAflH 3. A.. CAPY- 32 NAZARETIAN. R. A. BABAIAN. E. A.. SA- </) XAHHH >K. r,, MAPTHP0C3H A. C., AAPEUHHH T. B. O BO3MOWH0CTH npitMeHciiHJt RUKHAN1AN, Zh. G,, MARTIROSIAN, A S,, DARBINIAN, G. V. On possible uses of Y-aMiiiioMacJjHHoii khcaotu aas .leHemiH xpo* GABA in the treatment and prevention of co miHCCKiix intTOKCMKamn'i KCaiiTorcHaTaMii chronic intoxication by xanthates co 03 MH-THLUHHKOBA B. B.. CAMCOHO- 35 MILISHNIKOVA. V. V.. SAMSONOVA, N. F,, BA H. O., JIHXAMEB IO. n.. TOJIOBH- LIKHACHEV. Yu. P,, GOLOVINA. N. B.. HA II. E. FOPH30HTOBA M. H.. LIAJIAry- G0R1Z0NT0VA, M. N., PALAGUSHINA UJIIHA A, II. K Donpocv o AitaniocTii'iccKiix A. I. On the diagnostic capabilities of bron- bobmojkiioctbx OpoHxottHiOpocKonmi c npOBe- chofiberscopv-cum-transbronchial lung biopsy aciihcm TpaiicCpoii.xHa.Tbiioii fiuoncmi .acrKoro under roentgenologic control in a clinic of b K.ntiiiiKC npotpcccHoiia.xbiiux 3aCo.icBamu'i occupational diseases rHECIIHA E. A., niilEHHUblHA A. II. Rn- | 39 GNESINA. E. A.. PSHENITSINA. A. I. iiaMiiKa MacTOTU cepaesnbix coKpamemiH x Time course of the heart rate and galvanic KOJKiio-ra.ibBaitii'tccKitH petpACKC bo Bpe.MH skin reflex during night sleep in patients with HOHiioro cna v Oo.abnux c xponiciccboii npo- chronic occupational intoxication by vinyl (pCCCIIOlia.TbHOH MHTOKCIIKamieii BIIIlll.3X.30pH- chloride 59 iy.< KpatKHe cooGtueHHa Brief Communications HPVEBUM T. C., DOrOMOJIEU H. H-. BE- {42 BRUEVICH. T. S,, BOGOMOLETS. N. N.. PE30BCKIin A. R. O ccHcH6H.iH3HpyiomeM BEREZOVSKY, A. D. On the sensitizing jl'mctihih cooaimcHHH aparoueHHbix uerasi- action of compounds of noble metals (gold, .ioa -- 3o.ioTa, naaTHHU, pyTeHHH, poaHH, ce- platinum, ruthenium, rhodium, and silver) peGpa POJKKOBCKAJI T. n. B.iHHHHe wacaa h 6eH- |44 ROZHKOVSKAYA. G. P. Effect of oil and aitHa i(3 cnocoOiiocrb MacaopacTBopHMOH conn gasoline on the ability of the oil-soluble salt aHUHKaoreKCHaaMKHa npoHHKaTb nepe3 Heno- of dicyclohexylamine to penetrate through in BpextAeimyio kO/Kv tact skin J1HTAV B. r.. K3XHOBCKHn T.-EL osyXOBA M. O., PA31IHKHH C. M, /IEKAPEBA T. A. K Bonpocy 06 oneHKe ereneHH onachocth noBTopnoro BoaacficTBKB cwecH JieTy'iHx npOaVKTOB TCpMOOKHC.lHTC.3bHOA PCCTpyKHHH CMaaoHiiux uace.i 46 LITAU, V. G.. YUKHNOVSKY, G. D.. OBUK HOVA. M. F,, RAZINKIN. S. M.. LEKAREVA, T. A. On the evaluation of hazards from repeated exposure to mixtures of volatile thermal oxidation breakdown products of lubricating oils KPATIOTKHHA M. A.. TA/1HUKA3 B. A-. nPOMblC-IOBA A. R.. lOUIKEBHM Jl. 5. TAPKABEHKO O: C. MaTepHa.iw k oOochoBaHHio npeae.it.Ho aonycriiMoA kohixcHTpauhh CcCaUHKOBOH KI1C.10TU B B03ayXC pafiOHCH 30- Hbl 48 KRAPOTKINA. M. A.. GALITSKAYA.-V. A. PROMYSLOVA. A. D., YUSHKEVICH. L. B.. GARKAVENKO. 0. S. A proposed maximum allowable concentration for sebacic acid in the air of work areas P0U111H A. B.. KA3HM0B M. A. O b-thhhhh saiianna iia rcnepaTHSHVio 4>yHKnHJ0 axcnepHMCHTa.lbllbtX MIIBOTHUX 49 ROSHCHIN. A. V.. KAZIMOV. M. A. Effect of vanadium on the generative function of experimental animals MEJlbHHKOBA H. H. Xapaicrep KOMnnexcHoro acitcTBHH TpcxcepHHcroft cypbMW h pacnpeae.icHHe ee b opraHH3Me 51 MELNIKOVA. N. N. Complex action of anti mony trisulfide and its distribution in the body UIA/IAEBA M. n,, MOPnBEPT E. Jl. K bufiony onTHMa-ibHOH cxe.Mbi onpe,ae.ieHHH y.ib- TpiiMa.iux Ko.nmccTB 2II>Pb b kocthoh tkshh h CiiocyOcrpaTax 52 SHALAEVA. M. P., MORDBERG. E. L. Se lection of an optimal scheme for determining minute amounts of 3,0Pb in bone tissue and biological substrates ME.TiilIHKOBA C. A.. KABAKHH A. M., OP.IOBA T. B. H3yMeHe aKTHBHbix khohux rpynn iia noBcpxiiocTH HacTHir yrnefl pa3JiHHliwx CTaaini MeT3M0p$H3Ma 54 MELNIKOVA. S. A.. KABAKCHI. A. M, ORLOVA, T. V. Activity of acid groups on the surface of particles of coals having various degrees of metamorphism CbCSatl, COBeWaHHH, KOHIpCpCHUHH MEPEHHMK A H. Padonee cOBemaHHe mctoaiiMccKoii ccKuirti sCaHiiTapHO-rHriieHHHecKiie acncKTbi iiayHciniH npoH3BoacTBa mhkpoCho.lorH'iccKoro cmiTC3a Bcecojo3Hon npodneMiioft KOMitcciiii <HayHiibie ochobu nirweHbi Tpvaa it npod>ccciioHa.ibHofi naTo.iorim> (r. Kiipiiuni .IcmmrpaacKofi odnacTH, 2-- 3 oKTuOpa 1979 r.) Congresses, Conferences, and Other Ateelings 56 CHEREDNIK. A. N. Working session of the Methodological Section on Health Aspects of Studies on Microbiological Synthesis under the All-Union Problem Commission on Scien tific Bases of Occupational Health held 2-- 8 October 1979 in the town of Kirishi in the Leningrad Region PeUCH3HH K03IIK II. B. PcueH3iin Ha KHnry B. M. MaKOTHCIIKO, .1. O. .Mlixafl-IOBCKOH, B. Jl. LUeHHHiia h ap. rttniena Tpyaa h npo<t>eccHOHajtbnux aaGo.icaaiiHH b MCTa.i.ioodpadaTbiBaiomefi npoMuui.iciiHocTH. KneB, 3aopoB-H, 1979, 136 c. 3bIGK0BELl FI. Jl. PeueH3HH Ha KHtiry A. If. KiiKo.iOBa. y.MCTBeHHWH Tpya h smomm. AL. McaimiiHa, 1978, 368 c. Book Reviews 57 K0Z1K. I. V. Review of the book ``Occupatio nal Health in the Metal-Working Industry", by V, M. Makolchenko, L. F. Mikhailovskaya, B, Ya. Sheinin. et al.; Kiev. Zdoroviva, 1979, 136 p. 57 ZYBKOYETS. P. Ya, Review of the book "In tellectual Work and Emotions", by A. I, Ki- kolov; Moscow, Mcditsina. 1978, 368 pp. PexaxuHOH P. B. EOF E. H. B A. H. KOF A. M. MO pa), M. H. Ptain*ou E, E. AATt bo), m. t. A. B. SAB B. C BOA H. K. ABO TST11EHKO (Mocxoicxa HgmHH (. CEpeim), ^ (Motoi). rpA). K>. xmet). 30 (Moot**). R CO -------- --- Axpee M Tea. lCO-C 00 3i. peaa 00 Tcsm. p CFJspjHhHoT)h 60 a-7-22- VJlK SJ3.M2+l J.9|.-57S.7.22l-0$2: [612.172.1+ I2.79.0M.<231.-812.321.7 . A. THECHHA. A. M. IKUEHHUblHA (r. TopbicHu) AMHAMHKA HACTOTbl CEPAEHHblX COKPA1UEHHH M KO/KHO-rAAbBAHHHECKMR PEOJ1EKC BO BP EMA H04H0T0 CHA y EOJlbHbJX C XPOHH4ECKOH IlPO<bECCHOHAJIbHOH HHTOKCHKAUHEH BHHHJ1XAOPMAOM HiiCTitTyT rHfHCHbi Tpy^a u npocpaafioaeaaHHM Bo Bpe.Mii pa3.iu4Hbix CTaAHfl cHa MaCTOTa cepAeinbix coKpameHHH (MCC) ii KO/Kiio-ra.ibBaHHHecKHA peiJiAeKC (KTP), Kan h Apyrne BereTaTHBHbie ijiyiiKUini, npeTcpneBaiOT pnA 3aKonoMcpHbix H3MeHeHiiH (A. M. BeiiH). Tax, b noBepxHOCTHbix ctbahhx <|>a3bi MeA.leHHOBoAnoBoro CHa (MC) MCC no cpaBHeHiiio c 3Tm noKa3aT&neM npH OOApCTBOBaHHM CHHACaeTCH, HOHBAHK>Tch SecnopBAOBHbie KPP; b rayfioKHX CTaaiinx MC MCC B03pacTaer, KKP AOCTHraiOT MaKCHMa.TbHOH BblpalKeHHO* cth (Jl. n. JlaTam a coaBT.; Coccagua n coaBT.). C HaaaAOM t}5331*1 SbiCTposo.iHOBoro cua (5C) nyAbc ct3hobhtcs yHaUieHHbIM II apHTMHHHbIM, B03HHK3I0T 3KCTpaCHCT0.1bl. I"IpH 3TOM AJ1H BC 60-iee xapaKTepua BapitafieAbHOCTb pHTua. weM noBbiuiCHHe MCC; Krp b BC OfibJHHO OTCyTCTBVIOT. ripHHSTO CHHraTb. hto MCC a KTP oxpaJKaiOT coCTOflHiie 3MomiOHa.ibHOH c<|)epbi (Be* och). C 3TOH TOHKH 3pCHHH AafiHAbHOCTb MCC b BC KoppeanpyeT c nepextHBaimeM b 3TOH CTaAim 3MomiOHa.ibHo OKpameHaux chobhachiih, OAHano HaaCo.ibmaa nhipaxteHHOCTb KFP b rAyfiokhx cTaAiinx MC -- Ae.ibTa-cHe (IlC) npn oTcyTCTBiui CHOBHAeHHM npeACTaB.iHex aeKOTOpbiK napaAOKC. H3yaeHHe AiiaaMiiKH KrP bo BpeMH CHa noxa3a.10. HTO MaKCIIMa.IbHOe KOJIHHeCTBO Krp aafi.iiOAacTca b ilC BToporo h Tpexbero uiik.iob, yGuBaa k KOHay hohh, noraa 3MOmiOH3AbHOCTb CJIOBIIAeHHH OfiblHHO B03pacTacr (B. n. JlamiAHH h Jl. FI. JlaTam; B. C. PoTCHCcpr a coaBT.). 3th Aamibie no3Do.ia.iH Jl. n. JlaTainy bucK33aTb npcAno.io*eaae o AeMnc{>HpyiomCH pOAH HC C COnpOBOJKAaiOmHMH cro KTP n OTiiouieHiia Macroxu h 3momiona.ibiiocTa ciiOBiiAcaaa b nocneAylomax 3mi30jax BC. C no3auaa aacjiopMamioiiitbix xcopiia (Gaardner) coh npcjCTan.iHCT co6oa npouecc, xapaKTepii3ycMua aenpcpbiDHoa ncaxaMecKoa aktjiBiiocTbto, npOTeKaiomeH oco3HaBaeM0 -- B BHAC CIIOOIiaeHHH B BC HAH Heoco3iiaBac.MO--b MC. Cthtmoh aeoco3Haaac.MoA aKTiiBHOCTji b MC, no Mae* hhio Jl. n. Jlaxama, hbahkttch KrP. ripaKTHHecKoe OTcyrctbhe KrP b BC Jl. n. JlaTam o6"bHCHHeT no aHaAoraw co CHHJKeHaeM MUineiHoro TOHyca b 3T0H CTHAHH MeXaHH3M0M BerexaTHBHofi CjiOKaAbJ. HecMOTpa na to hto npaBeAeHHbie AaHHbie HyxtAaioTCH b AaAbHeftme.M BKCnepiiMeHxaAbHOM h kahhhnecKOM noATBepacAeHHH, ohh MoryrcayJKHTb OTnpaBHbIM nyHKTOM npH HCCAeAOBaHHH BereTaTHBHofi peryASUHH y SoAbHbIX C paCCTpOHCTBaMH CHa. Mu H3yua.iH MCC h KPP bo BpeMH HOMHOTO caa y Go.IbHbIX C CHHApOMOM OeccoHHHUbi, conyTCTByroiHHM xpoHHHeCKOH npO(|)eCCHOHaAbHOH HHT0KCHK3I1HH BHHH.lX.IOpHAOM (BX) -- OAHHM H3 AeTyHHX HapKOTHKOB, UIHpOKO HpHMeHHeMblM B COBpeMeHHOH XHMHHeCKOH npOMblUl.ieHHOCTH CKHTeTHHeCKHX HOAHMepoB (E. A. PHeciiHa h B. A. Ahtohjo- xteHKo). K-iHHHaecKH pa3AHiaioT paH- HH3K3 CT3AHIO HHTOKCHKaUHH, DpOTeKa- roiuyro c tfiyH^miOHaAbHO-AHHaMKHecKH* MH CABHraMH CO CTOpOHU HepBHOH CHC- Te.Mbl, a n03AHI0K3, Ha KOTOpoii BblHBAH- 10TCH opraHiiaecKaH caMnTOMaxHKa no- paJKeHHH CTBOAOBbIX OTAeJIOB rOAOBHOTO M03ra a CTBo.ioBO-ranoTaAaMHHeCKHe napOKCH3MbI (B. A. Ahtohio^chko) . Bcero 6u.io ofic.ieAOBaHO 20 Soabhux (9 Ha paHHeft CTaAHH HHTOKCHKaUHH, 1 ] Ha no3AHefl) b B03pacxe 30--50 act H 5 3AOpOBbIX Aim TOTO JKe B03paCTa (KOHTpoAb). OfimeKAHHHHecKoe oficieAoaaHiie BK-iioHaAO HenpepbiBHyio noAHrpacJmaecKVKD perHCTpauaw hohhoto CHa no CTaHAapxHoa MeroAHKe Rechtschaffen it Kales c 3anacbio 3KP h KrP c A3aohhoh noBepXHoCTH no H. P. TapxaHOBy. Ct3Ahh CHa onpeae-iHAH BH3yaAbHo no K.iacciK^iiKamia Tex Ate 3btopOB. MCC B 3nil30AaX OTAeAbHblX CTa AHH noACHHTbiBa.ia no ycpeAHeHHbiM noK33axe.iHM KO.umecTBa HHTepBaAOB Ha 3KT b Tpex 20-ceKyHAHbix otpe3Kax b ynacTnax 3anaca 6e3 AsaraTe-ibKbix apxeipaKTOB. 3a noKa3aTeAb .lafia.ibHOCTH b BC npHHHMana pa3HOCTb MeAtjy M3KCIIM3AbHbIM H MHHH* Ma.lbHblM 3HaieHHHMH MCC B 3TOM CTa- m Pwc. 1. Pacnpe.ie^cHHe KTP bo BpeMH hohhoi-o ciia. n<a <x opawK-ar -- <r*cTora (icojiHqecTBo a uftKyry) KTP; no cna (MC); ocm DC --06eauaiiccC--uccTtpaolHroKcnaM;CA^/ic--MKjOihBhOh^aK, OcBoocro- .'lHMHtotuaa ycpcJiH^KHWc aoKaa4Te.iH <ucTOtu KTP a MC (t. IK ilK IV cTaAHif) i BC y -nun Konrpo-ibnoA rpynaw; B -- to xe y tiojifcftwx ua paHHeft crinuu xpoHnneocofl npo^eccnoHa^ikHoA KRTOKcxicaiiMjt bmhh-i- x.'iopttaoM: C -- Ha noJaweB cTanuif KHToKCHKanax. ZLiui. Ha npoTSJKeHHH Bceii noJinrpac^HtccKori. 3anncn npoBOAHAH noAcneT a6co.itoTHoro Ko.uiqecTBa h nacTOTU KrP d MimyTy bo Bcex 3nn30Aax pa3AHHHHX CTaam'i CHa. FIoAyHeHHHe AaHHbie o6pa6aTUBa.ni CTaTHCTHHecKH c noMoiUbio iienapaMeTpimecKoro npHTepHH Bhakokcona -- MaHHa -- Yhthh (E. B. TyfiTOp H A. A. TeHKHH). HHHaMHKy KrP ii HOC conocTaBjiHJiM c OTHeTaMH 6oAb- HUX O CHOBHfleHHHX BO BpeMH BKCnepH-MCHTa.TbHOH HOHH. y .mu KOHTpojibHoft rpynnu a6coTKJTIIOe KOAHHeCTBO KFP LUHpOKO BapbiipoBa.To, coCTaB.iHS b cpeAHeM 1578. Hactotb KTP b nepBOM UHKAe npeo6AaAaAa b noBepXHOCTHUx cthahhx MC (I, II), CHiiwtaHCb b KOHue uHKJia bJXC Pnc. 2. AHHauHxa HCC bo Bpews HoiHoro cna. Ho opauHir --MCC (kojikicctho HTfpn,no* a--U h< 3KT i nHH>Ty); no och iOcuhcc -- to we, tTO na put, I; A arhhi, coeANKmoma* ycp4* HcHHUt OOOJ47UR HCC a MC (K IK UK IV cTaana) DC y ana aoHTpovikHoA rpynnu; B --* to X( y 6o- mui na paHHtA ctijhh xpoHHHecicoA npo<txtcyoHaafc- aCoTAa^HHHHTBowaTcOHiaccaruixaaauaaa, HHHJix^opicAou; C --- ha bojamcA h eiue 6oAbuie-- b BC; b ueAOM nacTO- Ta KrP b nepBOM UHKJie 6buia HH>Ke, Mew b nocJieayromHX 3--4 miKAax (pnc. 1). Ha^HHaa- co BToporo uhkas BbiHB.iH.Tacb onpeAeJieHHaa 3aKOHOMep- Hoctb pacnpeAeJieHHH KTP: HaH6o.nee HH3KH6 noKa3aTeJiH Ha6.nioAa^HCb b HOBepXHOCTHUX CT2AHHX MC BCeX UHK- jiob, HaH6ojiee bucokhc -- b HC, nepe- xoa ot JXC k BC conpoBOjKAaJica pe3- khm naiieHHeM aacTOTu KrP. HacroTa KrP b JXC npoAtwijKaJia B03pacTaTb ot BToporo ao aeTBepToro muuia, 33Tm CHH^cajiac^, xoth xapaierep pacnpeae- AeHHH KrP COXpaHHACH B HHTOM -- rnecTOM UHKJiax (cm. pHC. 1). HCC y jihu KoirrpojibHofi rpynnu bo BpeMH GOApCTBOBaHHH HenocpeACTBeHHO nepeA Ha.ioxceHHeM 3JieKTpoAOB cocraB- ahah 68 b MHHyTy. riepexoA ko CHy co- npoBOJKAaACH CHHJKeHHeM HCC. B nep BOM UHKJie HaHfionee HH3Kas HCC (59) OTMenanacb b noBepxHOCTHux CTaAwnx (I H II) MC, B TJiy6oKHX CTaAHHX MC h BC HCC HecKoJJbKO B03pacTa.ia. ZIh- HaMHKa HCC, xax h KrP, b nepBOM mifcne oTAH^anacb ot AHHaMHKH HCC b nooieAyiomHX iXHKJiax (pnc. 2). HaqH- Hasi co BToporo UHicna BucoKaa HCC OTMenanacb b I ctbahh MC; bo II-- IV CTaAHHX MC HCC 6una 6onee HH3- koh. I7pH nepexoAe k BC BHOBb ynamancH pHTM cepAeHHUx coKpameHHfi, y OTAejibHUx HccneAyeMUX noHBAHAncb 3KCTpaCHCT0AU, JIafiHAbHOCTb B BC B03- pacTa^a k KOHiiy hohh ao 10,3 koji/c. AOCTiiran b cpeAHeM 8,8 koa/c. Pa3Max KOAe6aHHH HCC -- pa3HOCTb MejKAy KpaHHHMH H3 npOTHIKeHHH Bceii 3ann- CH 3HaHeHHHMH HCC -- COCT3BAH.T 12,0. IlocAe npo6yjKAeHHH no cpaBHe- HHK3 C 60ApCTB0BaHHCM AO CHa OTMeHa- nocb ypeweHHe HCC Ha 10,5 koa/c. noAyneHHue npn nccAeAOBaHHH 3ao- pOBblX AHU pe3yAbTaTbl CBHASTeAbCTBO- BaAii o cao>khoh MHoroaTanHOH nepe- CTpowKe BereTaTHBHOH peryAHUHH bo BpeMH CHa C pa3AHHHb!M COHeTaHHeM Bara.nbHUx (cHHWeHHe HCC, KrP) if CHMnaTii KO-TOHHHecKiix (noBUineHHe HCC, KTP) 3cJx|)eKT0B h peminpoKHUM OTHOiueHiieM npeACTaBAenHocTH JXC n KTP b HaHaae hohh c B03pacTaromeH no Mepe hx naAeHHH qacTOTofi h 3Moixho- H3AbHOCTblO CHOBHAeHHH B npeAyTpCHHHX UHK.iaX. Y 6o.ibHUX na paHnefi ctbahh hhtok- CHKamm ofimee koahhcctbo KFP 6uao HCCKOAbKO HVfHfe. HeM y AHA KORTpOAb- hoh rpynnu,-- 1076, ho pa3AHHHH b ho pacnpeAeAe. y IOC n ine c; 33 p Hi fi :ne 5- 0) :hn Ui ot: Be CO CO k; 00 :of 3a 0o0 d6 CO HC Ui( CO H(t C (cm. pHC. 1 KOTOpUX MC HHH HaCTOTJ HHH EC. ( SMOUHOHaAl CHOBHAeHHH HCC y HHT0KCHK3I Aa Burne hoh rpynm KaK H B KO Aocb 3aMe; OAHaKO, 6o TeHAeHUHH TOM H nHT KOHTpOAbHf JlafillAbHOC HeHHKD C } CHHJKeHa HCC AO p<0,01) (8 koa/c; y 3AOpOBU O CHOBI GOAbHUX UHH. OAHT AeHHH He HHe CHOBH 6uao c})pa; AH CUeHU, uhh peunn H 3anoM: CUUieHHOC CHHJKaram AeHHOCTb HeKOTOpOH CKOH aKTli CT3AHH H Aee oahoc CHHJKeHHe cpaBHeHHf paHiaAH > nepejKiiBa fiOAbHUXw y 60Ab TOKCHK3U; KTP B n .ix.'ivra nfjnMttai::-V Syt? -*8Eh UeaOM H3CTO- : Gbi.ia mime, 3--4 uiiK.iax Toporo miKaa 3 33K01!0MCp- P: itaitGoaec -HOja.IHCb B AC Bcex uhk- 3 HC, nepe- 0>KJ3.1CB pc3- \TP. HaCTOTa 303paCTaTb OT HK.ia. 33TCM cp pacnpeae- B flHTOM -- 1). )l tc K 3) bi no teHHO rraB- 0: H C/A/J ? CO- nep- ai (591 HI CO CO IttHX C- 00 MC pa 00 Hh'P. BOM 1.M1 C 8 tc. . jHH- iconaa HCC MC;; bo II-- a Goaee hh3* BHonb yna- coKpauiemu'i, : noaB.iB.iiicu :Tb B BC B03- 3 10,3 K0.1/C. oa/c. Pa3Max 3CTb MCJKJV i see A 3ami-- COCTaB-ia.T no cpaBiiecua OTHena- 5 Koa/c. lOBaHHH 330- iiaejenbCTBO- 3 n h o it nepc- ryanuHH no coMCTaimeM ZC, KrP) it (noBbimettiKi eunnpoKMiJM I0CTH HC It iCTatotucft no It 3MOU1IO- peayipemtiix aaim iihtok> KTP Gbiao III KOHTpO-lb- pa3aH3llB B pacnpeaeaenint KrP He aoc-.ttrnaH ypoBHfl aocTOBepnocTH (/>>0,05).\jjac- npeaeaemte KrP no uHioiaM Gbiao b KOHTpoabHOH rpynne it y GoabHbix Ha paHHeH CTaanH,-- b cpeaHeM 459,5 (P<0,05). HeTepMHHHpOBaHHoe pac- cxoatto c pacnpeaeaeHHeM b KOHTpoab- npeaeaeHHe KFP "no craaitHM BHyTpn nott rpynne: MHHHMaabHbie 3HaneHHH b UHKaoB oTCyTCTBOBaao: no cpaBHeHHio 5C, MaKciiMaabHbie -- b ZIC. HanGoab- c KOHTpoabHOH rpynnoA nacTOTa KFP b tueA nacTOTbJ KFP aocTHraaH b ZIC neT- MC Guaa Hnnce (P<0,01), a b BC -- aepToro minaa. Ot.ihhhc pacnpeaeaeHHH Bbiine (P<0,05); TeHaeHUHH k ycTaKFP ot KOHTpo-ibHOH rpynnu Gbiao cbh- HOBaeHino MaKCHMVMa KrP b ZIC aaito c ocoGeHHOCTHMH CTpyKTypbi CHa -- TpeTbero h neTBepToro unicaoB, KaK y coKpauiemteM aaiiTeabHOCTH ero h yMeHb- GoabHbix na paHHefi CTaaHH, He orwe- tuciiiieM KoannecTBa uhiuiob 30 4, pe naaocb (cm. pnc. 1). nce -- 5. Cyan no pacnpeaeneHHio KrP HcxoaHan HCC nepea 3acwnaHHeM ( CM. pltC. 1 ), OTCVTCTBOBanH UHKJlbl, B y GoabHux Ha no3aHefi CTaaHH hhtokch- KOTOpUX MOJKHO Gbiao OIKHaHTb CHHJKe- KauHH Ghiaa CHHJKeHa ao 58. OTMena- HHH H3CT0TL1 KFP B ZIC II B03HHKHQBe- aocb aocTOBepHoe no cpaBHeHHio c HtiH BC. conpoBoncaaeMOro HanGoaee KOHTpoabHOH rpynnoA CHHJKeHHe pa3- BMOUIIOHa.TbHblMH, 3anOMHHaK3IIIHMHCH Maxa KoaeGaHHH HCC (5,3 Koa/c; cnoBiiaeintHMH. P<0,05) h aaGnabHOCTH HCC b BC HCC y GoabHUx Ha paHHefi CTaaHH (3 Koa/c; P<0,01). npH stom HCC itHTOKCiiKamui nepea 3acwnaHHeM Gbi- nocae nepBOHanaabHoro 3aMeaJieHHH b aa Bbtine (70), ^eM y aHu KOHTpoab- nepBOM liHKae oGHapyiKHaa TeHaeHUHio noft rpvnnu. FIpH nepexoae ko CHy, k HeyicaoHHOMy B03pacTaHHio b nocae- Kan h b KOHTpoabHOH rpynne, HaGaioaa- ayiowHX UHicaax: B HTore HCC nocae aocb aaMcaaemie HCC, KacTynaBinee, npoGymaeHHH npeBbiinaaa HCC ao CHa oanako, Goaee noCTeneHHO (cm. pHC.2). Ha 7,2 Koa/c (P<0,01). TeHaeHuint k CHHJKeHino HCC b neTBep- CHOBiiaeHneCKaH aKTHBHoerb y Goab- TOM it nUTOM UHKaax B OTHHHHe OT hmx Ha no3aHeA CTaaHH HHTOKCHKauHH KOHTpoabHOH rpynnbi He HaGaioaanocb. OTannaaacb cKyaHOCTbio, CHOBHaeHHH .la6iiabiiocTb b BC (4,2 Koa/c) no cpaB- Gbian peaKHMH (y 4 GoabHbix H3 11), ncmtio c KOHTpoabHOH rpynnoA Gbiaa npocTbiMii no coaepHtaHHio. CaeayeT cmtJKeiia (P<0,05). Pa3H0CTb Memay noaaraTb, ^to Ha no3aHeA CTaaitH hh- HCC 30 n nocae CHa (5,0 Koa/c; TOKCHKamiH oaHHM H3 t^aKTOpOB, CTOH- P<0,01) it pa3.\iax KoaeGaHHH HCC mitx b oGmen naToreHeTHnecKoA uenn (8 Koa/c; P<0,01) Guan MeHbine, neM c oGeaHeHHOCTbio CHOBHaeHHecKOH aK- y 33opoBbix aim.' TIIBHOCTH, MOH<eT GbITb HH3K3H H MOHO- O ciioBitaeHHHX cooGmuan 6 H3 9 TOHHaH, He aHtp^epeHintpOBaHHan no uoabitbix na paHHefi ct33hh hhtokchk3- CTaaitHM 11 UHKaaM npeacTaBaeHHOCTb tiHit, OanaKO 3 H3 hhx nocae npoGync- KFP h HCC. aemiH tie Moran BcnoMHHTb coaepHta- TaKHM o6pa30M, aHaaH3 paenpeaeae- 1I1IC CHOBHaeHHH. OnncaHHe CHOBHaeHHH hhh KTP h HCC bo BpeMH CHa y Goab Gbiao (pparMeHTapHbiM, BKaioHaao aeTa- Hbix c xpOHitnecKOH npotpeccnoHaabHoA ,ni cnciiu, a He bck) KapTHHy. C no3H- HHTOKCHKamteA BX BbiHBita xapaKTep- IIIIH peUltnpOKHOH 3aBHCJIMOCTH HpKOCTH Hbie pa3aH*iHH b pitcyHKe paenpeaeae- :t aanoMtiHaeMOCTH CHOBHaeHHH or Ha- hhh BereTaTitBHbix noKa3aTeaeA Ha paa- cumemtocTii ZIC KrP BbiconaH, He Hbix CTaailHX HHTOKCHKauHH. cttuncaioiiiancH ao KOHua ca npeacTaB- Flo paHee noayHeHHUM hjmh aaH- acmtocTb KFP b ZIC KoppeanpoBaaa c HblM, aHCCOMHHMeCKHH CHHapOM, B03HH- itcKOTopon ofieaHeHHOCTbio cHOBiiaeHne- KaKnuHft npn xpoHHnecKOH npotJieccHO- CKoft aKTitBHOCTH v GoabHbix Ha paHHeit HaabHOH HHTOKCHK3UIIII BX, CBH33H C cTaann miTOKCtiKauHit. OneBitaHO, 60- ycnaeHiteM c{)H3HqecKHX aKTHBaunoH- acc oanoo6pa3HOe pacnpeaeaeHHe HCC, Hbix caBjtron na paHHeA CTaaHH hhtok- citiincenne aaGitabHOCTit HCC b BC no CHKauttn it npeoGaaaaHtteM tohhhcckoh cpamicimio c KOHTpoabHOH rpynnoA ot- aKTHBamtH Ha no3aHet"i (E. A. FHecttHa pancaatt yMeHbtneHHe sMomtOHaabHOCTH h B. A. AHTOHioiKeHKo). 3to aaeT oc- nepc/KHBaHiiH bo Bpevtn CHa y 3thx HOBaHIte CHHTaTb, MTO H3MeHeHHe CHO 6oabttbix. BHaeHHecKOH aKTitBHOCTH it pitcyHKa V GoabHbix Ha no3aHeft CTaaHH hh- BereraTtiBHoA opHaMeHTaunn CHa y H3- TOKcitKamtH aGcoaKJTHoe KOvinnecTBO yneHHbix H3mh GoabHbix OTpamaer He- KTP b noanrpaMMax Gbiao HH/Ke, neM onTHMaabHoe TeneHite HHtpopMaunoH- 41 ubix npoueccoB 11 HapyiueHHe BereraTHBnoft pery.iHixini Ha 4>OHe aKTHBamtoHiiux canwroB. Pc3v.TbTaThi npoBejeHHHx HccjieaoB3HHH J103BO.THIOT nOTtOHTH K OOHHMahhk3 naroreHe3a BMomioHa^bHMx h BereTaTHBHbix HapymeHUH, conpoBOJK^aK3I11IIX ailCCOMHIIHeCKJIH CHHApOM npit HHTOKCHKamui BX, a Taicute apyrtiMH HapKOTlmeCKHMH fljaMH, H, KpOMe Toro, jaroT ocHOBaHiie ana peuieHHS 3aAann naToreHeniHCCKH ofiocHOBaHHofi Tepanim 3THX HapyujcHHii. BblBOAbl. 1. npH AHCCOMHHHeCKOM cmupoMe, conpoBo>KjiaiomeM xpOHHaeckvhd npotfiecciioita.ibHyio hhtokchk3uiiio BX, oTMeiaeTCH H3MeHeHne koahnecTBa h pacnpeje-ieHHH MCC h KrP bo Bpevtfl ciia. 2. Ha paiiHCH cTaAim HHTOKCHKaunn HiiBe.iHpyraTCH pa3.niHHH b npeacraB- .lenHocTH KTP b 3mi30^ax HC Ha npo- TB/KeHII II HOHli; CHlIIKaeTCfl Jia6Hjlb- HOCTb MCC H BC, 3. Ha no33HCH cramm HHTOKCHKamui KO-IIIMCCTBO KTP vMeHbmaeTCH H HCqe- 3aeT acrepMHHitpoBaHHOe pacnpeae-ie- He KrP no (pa3aM h uhkji3m; JiaOHJib- IIOCTb MCC B 5C HH3K3H, pa3jlHqiIH MCC b MC ii BC cr.Ta>KeHbi. .1HTEPATVPA Ahtomoxckko B. A.-->K. ReBponaTOJi. h nciixHarp.. 1973. X 3. c. 377--382. Bcuh A. 31. HapvuicmiH CHa h SoapcTnosaHHa. M.. 1974. rmtuNcJE. A., AHTomoxeHKO B. A. -- B kh.: Bce- fCI03!Jb)fl CHMIT03HyM HO JCAHHHKe, AHarHOCTHKe 3aPoJI6BaHKH XHMHHCCKOH BTHOAOrilH. l-H. teiHChi AOiKxaAOB. Khcs, 1977, c. 65--67. rjQAzJ E. B... remain A. A. npHMCHeHMe KpHTe- Phcb HenapaMeTpHiecKOH CTaTHCTHKH aah oueH- kh pa3.iHiHH rbvx rpyira HaC.noneHMH b mcahKo-6iioaorHiecKHX HCCAeAOBanHHX. M.. 1969. ttamuiuH B. 77., Jlajaui JJ. 77. -- <t>K3H0,i. jk. CCCP. 1975. -V* 3. c. 362--366. JJaram JI, IT. -- B kh.: <X>H3HOAorHH qesoBeKa h jkhbothwx. M,, 1975, c. 94--152. PorenSepe B. C., Konyded B. H., LUoxnapoetiH B. M. -- JK. Bbicui, HepBH. flejrr., 1975, Vi 4, c. 858--861. Bloch V. -- Ann. Psychol., 1952. v, 52, p. 97. Coccagna 0.. Moscheu 7?., Vela A. et al. -- Rev. Nevral., 1977, v. 17. S. 491--506. Gaardner K. -- Arch. gen. PsychiaL, 1966, v, 14. p. 253--261. Rechtschaffen A., Kales A. -- A Manual of Stan dardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Bethesda, 1968. nocrytt8*ia pci*>cuh>o 21/VIII 1979 r< TIME COURSE OF THE HEART RATE AND GALVANIC SKIN REFLEX DURING NIGHT SLEEP IN PATIENTS WITH CHRONIC OCCU PATIONAL INTOXICATION BY VINYL CHLO RIDE. E. A. Gnesina and A. 7. Pshenilsina The heart rate and galvanic skin reflex were studied in polygraphic records of night sleep in 20 patients with chronic occupational intoxicati on by vinyl chloride, a compound with narcotic action. A correlation was established between the impoverishment of the dream pattern and the changes in the heart rate and galvanic skin reflex distribution patterns. Characteristic dif ferences between these patterns at different stages of intoxication are described. KPATKHE COOBLUEHHJI >AK I.S-0S.4J^>S7-<W:|S,S+M6.S2+S4.9# + 54.S7 T. C. DPVEBHM, H. H. EOrOMOTIELL A. 71. EEPE30BCKHFf (MocKsa) O CEHCHCHJIH3HPyiOLUEM EEflCTBIIH COEflHHEHHB 7I.PArOU,EHHbLX METAJ1J10B -- 30710TA, nJIATHHbl. PYTEHHJI, POAHH. CEPEBPA IlitCTHiyr rumens! Tpyja n npotpaifio.ieBaHiiii AMH CCCP A.3.ieprHiccKiie AepMaTHTM npa Kouiairre c pacTBopoM ttiiainicroro ao.iora 6waii oniicaHU E. A. Cohobum ii T. 71. Xai'iuoBCKHM b 1964 r, IhsecTiiu. c-iy*i3H Cutoboh a.i-ieprHH. paatiRBlUCl'lCB BO:e3CTBIIC IIOUICHHH 3030TUX H33C.1Mik (Comaish; Elgart u Higdon). 42 A. A. AHTOHbCB Hafi.noaaa 3 Oo.ibHux npo- [JieCCHOHaniiHOH SKSeMOk, B03HHKineH OT KOHT3K* Ta c asaTiiHox-iopHCTOBOflopoanofi kiicjiotoA. 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UttaRHCTUH KaAHft, a3one KHC-ioe 3Ke.ie30, ejiari t: H3 44 padorawmHX bi ah o6c.iejOBaHbi 34 atw 40 ACT CblAO 14 HCAOBCI 18. erapme 50 act -- 2 : paSoTU Ha aaBoje ( I aexax) jo 5 -ieT 6ns y 10 act -- y 9, canine 1 (h3 hhx y 7 canine 20 .' AaAH CTaxtHpOBaHHne pi CTBO COACH AparOaeHBliJ iocs Ha saBOAe 6osee K BeK CpOKH padOTU B ECI'(23 padoraxH ao 5 act). nan eneHiiaAH3anHX p>6- 15 -- cc pa a 4 HeAO mi AaAHS. H3 34 p pOBaHHblWH np0H3B0AC7! K0B3.ieH7Ha COeAHHeHHH HBAeaa y ! Bau ahSH BH.iacb na wymeeTBeH H n-iaTHHb1 Pacnpe is JO {*> CO art: teas ~-x CO CO 00 ,-o k: id* 00 JSH2 to j p>- BbJH! peaxnnA i c IC OKasaAOCb nun: y 10 leAOBeic, TpKXio; rHApOXCBAXAOpHA --- >' Ahh -- y 3 h AayxAO? nAaTHHOXAOpHCTOBOAOpC AOBCK. K PC3HHC (ncpB- CTBH-reAbHOCTb pa3BHAa ne padoTaBinttx c bthm Hbie BeuiecTua peaimHi TaKHM o6pa3on, Ha renauH oxaaa.iHcb coe coah AHnHaHaypaTa xa co.ib cepefipa a.TAeprcr Aa.ia. B paBHoii crest AeAcrsHe OKaanBa-iH c