Document RJkvqpOQnO9ZmZZrGYpVKw8gz

\n Annals Hew York Academy of Sciences Cltemie. W. Focrst, Ed. Vol, 14: 306. Urban A Schwarzenbcrg. MUnchen, West Germany. v-- ----------------- 100. Oster, R. 11., C. J. Carr A 3. C. Krantz. 1947. Ancslbesin. XXV11. Narcosis with vinyl chloride. Anesthesiology 8: 339. 101. Ostermayer, H. 1967. Vlnylchlorid. In Ullmanns Encyklopkdle der technischen Chemie. W. Foerst, Ed-Vol. 18: 87.JJrban A Schwarzenberg. MUnchen, West Germany. 102. Orro, P., P. H. Kjiaose. H. G. Jester, F. W. Scuaudt A X. H. Glatzel. 1972. Idiopathische portale Hypertension. Med. Klin. (Munich) 67; 447. 103. Parmeggiani, L. A C. Sassi. 1955. Rischl e patologia professionals net la pro- duzionc e nella lavorazione di alcune malerie plistiche. Med. Lavoro 46: 14. 104. Patty, F. A., W. P. Yamt A C. P. Waite. 1930. Acute response of guinea pigs to vapors of some new commercial organic compounds. V. Vinyl chloride. Public Health Rep.^5: 1963. ... Pi W.-Faasctt-dL-P. D. Irish, Edi Jnd-edih-interscien _ ____ 107. Peoples, A. S. A C. O. I.EAitE.cSisil.'The anesthetic action of vinyl chloride./J. Pharmacol Fxntl. Ther 48: 284 v------ ronat hypertension (band's syndrome). Ann. Jnlemal Med. 56t oze. Popper, H., F. Paronetto, F. Schaffner A V. Perez. 1961. Studies on hepatic fibrosis. Lab. Invest. 10s 265.^ _ __ HlypgnEtnlon^NToll>hlarirolC *Cd-Gee7^g-JPhieme-V<^^g.^3(ut^gm7^^yest-Qer^ eV v-tenailJrnIlylTT 111. Popper, 11. A F. Hutterer. 1970. Hepatic fibrogenesis and disturbance of hepatic circulation. Ann. N.Y. Acad. Sci. 170: 88. 112. Popper, 11. A S. Upenfriend. 1970. Hepatic fibrosis. Correlation of biochemical and morphologic investigations. Am. J. Med. 49t 707. 113. PustttN, G. A. 1965. O porashenii peienl l zeltnylkh pule: u raboiikh' zan- jalyikh w proizwodstwc nckatoryikh widow plaslmass. Sov. Med. 28: 132. 114. PVC producers see good business ahead. 1969. Chcm. Eng. News August 4: 18. 115. Quooss, H. 1959. Gesundheitsgefahren in der Kunstsloffindustrie, Johann Am- brosius Oarili Vcrlag. Leipzig, East Germany. 116. Ramalinoaswamj, V., K. L. Wto A S. K. Sama. 1962. Cirrhosis of the liver in ,, Northern India--a ctinicqpalhological study. Arch. Internal Med. llOt 350. OP'"'ll7. Ramalinoaswami, V. A N. C. Nayak. 1970. Liver disease in Indie. In Progress in W> liA'lfSH'/ NLievwerYDoisrke.asNe..YH. . Popper A F. Schaitner, Eds. Vol. Ill: 222. Grune A Stratton. 118. Rappaport, A. M;, M. Knoblauch. R. G. Black A S. Oiiira. 1970. Hepatic microcirculatory changes leading to portal hypertension. Ann. N.Y. Acad. Sci. 170t 48. 119. Ravenna, P. 1940. Band syndrome (fibrocongestive splenomegaly). Definition, 120. 121. classification and pathogenesis. Arch. Internal Med. 66: 879. Reaimer, H. 1970. The role of the liver in drug metabolism. Am. J. Med. 49: 617. Reynolds, T. D. A A. G. Redeker. 1965. Hepatic hemodynamics and portal hy pertension. In Progress in Liver Disease. H. Popper A F. SchatTner, Eds. Vol. II: 457. Grune A Stratton. New York, N.Y. 122. Rotii, F. 1957. Arsen, Leber, Tumorcn (lUmangiocndothtliom). Z. Krebsforsch. 61: 468. 123. Rousselot, L. M. 1940, The late phase of congestive splenomegaly (Band's syn drome) with bematemesis but without cirrhosis of the liver. Further observa tions on die etiology of Band's syndrome and the effect on prognosis of certain variations in the portal venous pattern. Surgery It 34. 124. Sama, S. X., S. Bharoava, N. Gofi Natii, J. R. Talwar, N. C. Nayak, B. N. Tandon & K. L. Wto. 1971. Noncirrhotic portal fibrosis. Am. J. Med. 51: 160. 125. Saragoca, A., M. H. Tavares, F. &. Barros A I. Da Silva Horta. 1972. Some clinical and ;accrtory findings in patients injected with thorium dioxide. Study of 153 esse:. Am, J. Gastroenterol. 57t 301. 126. Schaffner, .". A H. Popfer. 1963. Capillarizaiion of hepatic sinusoids In man. Gastrcer.'.:rc:c;y 44t 239. TOOSCGfrZ Z0S9EOH9 Marstcllcr el at.: Splcnomegalic Liver Disease 127. ScitAUMANN, O. 1934. Uebcr die llcrzwirkung einiger Inhelttior.ir.Erkstica. Medi* zin A Chemie. Abhandlungen aus den Mcdizinisch-chcmischcr. .-cricf.ungsstStten der I.G. Farbenindustrie A.G. Vol. II. Bayer-Meisur Lucius. Leverkusen, West Germany. 128. Sciiaumann, O. 1938. In Toxikologic und Hygiene der technischen Lbsungsmittel. K. B. Lehmann A F. Flury, Eds. p. 130 (Monochlor'athylen). Julius Springer. Berlin, Germany. 129. Sciimid, M. 1968. Zur Leberhistologie der verschiedenen Formen des porlalen Hochdruckes. In The Therapy of Portal Hypertension. N. G. Markoff, Ed. Georg Thieme Vertag. Stuttgart, West Germany. 130. Schmidt. F. W. 1969. Gcringer Aktivitaisansiieg der Scrum-Transaminasen. Deut. Med. Wocbschr. 941 2250. 131. Sciinack, H., L. SroCKtNOER A F. Wewalka. 1967. Adventitious connective tissue cells in the space of Disse and their relation to fibre formation. Rev. Intern. Hdpatol. 17i 85J. -132. Gimohus, ll.'TC.'TC. 1. Wutn-A-M^^M)iCEU)W^4949Hiandbook~Trf~PllStlCf. 2IHl /,,>,, ^edii n ajuatAiiunii r n rr'i,~uiiiii-rA,vr)4a.-- 133. Slater, T. F. 1972. Free radical mechanisms In tissue Injury. Plon Ltd. London, England. 134. Smoron, G. L. A H. A. Battifora. 1972. Thorotrast-Induced hepatoma. Cancer 30t 1232. 13J. Smyth, H. F., Jr. 1956. Improved communication. Hygienic standards for daily inhalation. Am. Ind. Hyg. Assoc. J. 17: 129. 136. Soloway, R. D., A. H. Bagoenstoss, L. J. Sciioenpield el nl. 1971. Observer error and sampling variability tested in evaluation of hepatitis and cirrhosis by liver biopsy. Am. J. Digest. Diseases 16: 1082. 137. Stein, G., S. JOiie, C.-E. Lanoe A G. Veltman. 1973. BandfSrmige Osteolysen in den Endphalangen des Handskelelts. Fortschr. Gebiete Roenlgenslrahlen Nu- klearmed. 118: 60. 138. STENGER, R. J. 1965. Fibrogenesis along the hepatic sinusoids in carbon-lelra- chloride-induced cirrhosis. An electron microscopic study. Exptl. Mol. Pathol. 4t 357. 139. Stutz, F. H., D. C. Toamey A J. Blom. 1973. Hemangiosarcoma and pathologic rupture of the spleen. Cancer 31: 1213. 140 Suctu, I., I. Drejman A M. Valasxai. 1963. Contributii la sludiul imbolnavirilor produse de clorura de vinil. Med. Interna 15: 967. 141. Suctu, I., I. Drejman A M. Valasxai. 1967. Elude des maladies dues au chlorure de vinyle. Med. Lavoro 58: 261; Abitr. Hyg. 43: 430 f 196*5 142. Summerskill, W. H. J. 1974. Chronic active ' M hj mined: prognosis hopeful. Gaslroenterology 66: 450. W -- r> 143. Sussman, E. B., 1. Nvoick A G. F. Gray. 197- M M helial sarcoma of the liver and hemochromatosis. Arch. Pathol 1 === k 144. SyManski, H. Ed. 1963. Handbuch der gesam Ed. Vol. IV/2: Arbeitshygiene. Urban A Sc t. E. W. Baader, ichen, West Ger- many. 145. Tandon, B. N., R. Laksiiminarayanan, S. BttA 1970. Utlrastruciure of the liver in non-cirri UC A S. K. Sama. i with portal hy- pertension. Gut 11: 905. 146. Tisdale. W. A., G. Klatskin A W. W. L. GLe bleeding esophageal varices. Their occurret hepatic and ejctrahcpatic obstruction of the p 209. 147. Torkelson, T. R., F. Oyen A V. K. Rowe. IS as determined by repealed exposure of labor U " (J W ~ w> typerlension and : of both intratgl.l. Med. 261: if vinyl chloride i. Ind. Hyg. As- soc. J. 22: 354; Bull. Hyg. 37s 357. 148. Tribukii, S. L, N. P. Tikhomirova, S. V. Levin Iruda i meropriyatiya po ikh ozdorovleniyi khlorvinilovykh plostiieskikh mass. Gigiena S 149. TRumRT, L. 1959. Aspects loxicologiques de I .a w Q\ 1949. Usloviya i izpol'zovanii t iires plasliques. Arch. Maladies Profess. 10t 43. 150. U.S. Department op Health, Eoucation. and Welfare--Public Health Ser vice: Center for Disease Control. 1974. Angiosarcoma of the liver among polyvinyl chloride workers--Kentucky. Morbidity Mortality Weekly Rep. 23(6): 49. VNOTICE TIilS ' 284 PROCEEDINGS the testes with epididymes in the control rats was 4.(11 grains us con trasted with 1.64 grams average weight in the experimental rats. The average weight of the prostate gland in the controls was 0.S3S gram; 0.162 gram in the experimental animals. The average weights of the seminal vesicles in the control and experimental groups was 0.467 and 0.063 gram respectively. Histologic study of sections of the sex glands showed an atrophy of the glandular elements of the prostate gland and seminal vesicles and of the germinal layers of the seminiferous tubules of the testis, par ticularly a disintegration of the primary and secondary spermatocytes and of the spermatids, in the rats fed beef testis. No change of moment was noticed in the interstitial cells of Leydig. The stroma of the differ ent sex glands did not show any definite change, though the Btromal portion of the tissues appeared relatively prominent on account of the atrophy of the glandular elements. The Anesthetic Action of Vinyl Chldride. Anderson 8. Peoples and C. D. Leake, University of California. Vinyl chloride (CH -- CHC1), first prepared in 1833, is a gas at ordi nary temperature (B.P. --13.9 C.), heavier than air and with an ethereal odor. In concentrations of 4 to 20 per cent in air it may be burned, but with difficulty. It is doubtful if It polymerises to any great extent in the absence of light. In studying its toxicity, Patty et al. (Pub. Health Rep., 1930, xlv, 1963) noted its narcotic action. We found its minimal anesthetic range on mice exposed for ten minutes to be 3.6 to 5 millimols in air, while its minimal lethal range at ten minutes exposure is 10 to 12 millimols in air. It thus has a wider margin of safety than ethyl chloride, although it is not quite so powerfully anesthetio. At a con centration of 7 millimols in air it anesthetises larger animals such as rabbits and dogs within a minute. Recovery U very rapid, and with no apparent untoward effects oven after prolonged anesthetization. Recovery of Morphine from the Tissues of Tolerant and Non-Tolerant Dogs. O. H. Plant and I. H. Pierce, State University of Iowa. A method is described for the extraction and estimation of small amounts of morphine, which gave Connietunt results (95 to 110 per cent recovery) when the alkaloid is added to normal tissues. The experiments were planned so that the results could be directly compared between tolerant and non-tolcrant dogs under identical condi tions. Results are given for the reoovery of morphine from liver, muscle, central nervous system, heart, lungs and blood and from the excretory 4-' organs and excretions. Twenty-four dogs were used, half of which had received hypodermioally a single dose to 60 mgm. morphine sulphate pi per kilogram and half had received daily a dose of the. same size for periods of approximately one year to more than four years. Environ mental and nutritional conditions of all the dogs were oarefully con trolled. All were kept in metabolism cages and both food and water were given by stomach tube for intervals before the tissues wore exam ined. Tissues from an equal number of both tolerant and non-tolerunt zuosm-z Gd a u> ON Ur O -1^ i PROCEEDINGS 285 dogs were analyzed for morphine 4 hours and 24 hours ufler the dose. The tissues and body fluids sampled amounted to 54 to 66 per cent of the body weight. The average total recovery from the six tissues examined four hours after the dose was greater (42.8 per cent) in the non-toleront dogs, while in the same tissues, examined 24 hours after the dose the average total recovery was greater (46.2 per cent) in the tolerant animals. The average concentration in these times showed the same type of difference. Of the individual times, muscle yielded the largest amounts but the concentration in muscle was of the same order as the other times. The central nervous system in the tolerant dog contained less than the nontolerant ones. The blood of tolerant animals contained more than of non-tolerant. The average concentration in the liver was greater than in the other tissues. The amount of morphine in the kidneys and urine was practically the same in tolerant and non-tolerant dogs at the end of four hours, but it was greater in the tolerant dogs at the end of twenty-four hours. The alimentary canal and its contents yieldod much more morphine in the tolerant animals than in the non-tolerant ones in both tqe four-hour and in the twenty-four-hour group. The percentage of the dose recovered in the tissues and excretory organs of non-tolerant animals was distinctly less in the twenty-four^ hour group than in the four-hour group, while in the tolerant dogs the percentage of the dose recovered was greater twenty-four hours after the dose. The results suggest there is a difference in the manner in which mor phine is handled in tolerant and non-tolerant dogs. The larger amounts recovered from tolerant animals, as compared with non-tolerant ones, twenty-four hours after the doso, indicates that increased ability to "destroy" morphine is not a (actor in tolorunce. Thera Is some evi dence of storage of morphine in the tissues as well as in the alimentary canal. A Comparison of the Action of Pentobarbital (Nembutal) and Sodium Barbital in Rabbits as Related to the Detoxicating Power of the Liver. T. W. Pratt, Univorsity of Wisconsin. In rabbits there exists a close relationship between the functional activity of the liver, as determined by absorption of bromsulphalein from the blood, and the duration of the action of pentobarbital (nem butal). In animals poisoned by phosphorus or carbon tetrachloride so as to significantly delay the disappearance of bromsulphalein from the blood, thoro is found a prolonged period of depression by pentobarbital. On the contrary, the durution of the action of sodium barbital docs not appeur to be influenced by tho excretory function of the liver. Conse quently, one is justified in concluding that the short period of depression by pentobarbital is due to its destruction in the liver. The long dura tion of action of Imrbitul, on llio othor hand, lining unchanged by livor poisoning, is obviously due to tho fact that it is so stable it is normally excreted by the kidneys up to.approximately 86 per cent. BFG36505 n 2493666* cs a oOw i i TOT I