Document QkeoQyX4j3z3oxGqQ5O35o5j5

AR226-3074 gTliriv T i t l e Inhalation Toxicity Screen with T,n^r-a t-Qrv P ro ject-IB HL-1997-00599 author David P. Kelly gmriv Completed July 11. ISS"7 porformir" Laboratory b- I. du Pont de Nemours and Company Toxicology and Industrial Medicine Haskell Laboratory for Toxicology Elkton Road, P. 0. b o x ou Company Sanitized. Does not contain TSCA CBI Page 1 of 2 Tnhaiaf ion Tpv;^itv screen .Jta H-22484 Ln inhalation toxicity screen was ducMd procShe" ^ AI005-T. The tours to H-22484 according s^ aying Systems Nebulizer. The aerosol :est substance was aerosolize analysis of filter samples. After itmosphere was analyzedbygra me ilter>.werB innnediately weighed to iilter samples were collected. After overnight drying in a letermine the wet aerosol cn=e^ f ^ _ hed to determine the dry aerosol lesiccator. the filter the four-hour exposure were /eight. The mean aerosol ^o^centr fterosoi mass median aerodynamic 110 mg/m3 (wet) and 400 mg/m (dry> ' t showed a diminished alerting liameter was 4 pm. During the exposure q however all rats died within response. No deaths occurred 'our days of exposure. Upon unloading the chamber, clinical signs of 484 re irregular respiration and observe i. the r.te hour, eft.r expo-- *. on. Lethargy. Three of six rat* rat died on the day after exposur . died two days after exposure and exposure. After the exposure rats the remaining rat died three f ^ ^ Clinical signs observed during the continued to lose weight yhunched posture and irregulayggpxration. ^ ^ ^ ^ r iz a tion of Hvmber ftTMPhexfi- PHamber ftarosol an Cone. SD Range g/m3) ft /ilrv AAf) Pfirt-i c l e BiTif ftPa l v s l s MMAD* GSIT %<lpni %<3pm *<10um Mortality Deaths/Exposed Work by ' 1l - 7 ,/fL M. A. Pulliam, B.S. Toxicology Technician Study Director t Inhalation y. Kelly, B.S. ellular Toxicology 3 m m a d = Mass Median Aerodynamic Diameter (pm) b g S D = Geometric Standard Deviation w t Company Sanitized. Does no! contain TSCA CBI