Document QXpowJV85L3R0ggRZJza39Dzk
DEAR CUSTOMER
DUE TO A CLERICAL ERROR, THERE ARE NO
ORIGINALS FOR THE BATES RANGE SHOWN
UHL 00929
*_
Photocopying Digital Pitting Document Imaging ManagementServices
Liver Angiosarcoma Cases
&Fxr
Circulation
Dr K S l/llliamson
t
Pr G Puddle
Dr D P Duffield
Dr W G F Adams - (5 copies - 1C1A,
Mr G J Sleddon/Mr J M Sheaff
Dr D W Plester
Mr L F 11111, Millbank
Hr Brian Hasler, Vinatex
Mr A E H Williams, BP
Mr R H Hards, B1P
Dr J T Carter, BP
Mr T L Phillips, BP
Dr P Lewis, CIA
Dr J R Tasslgnon, Solvay
Mr J C Thomas, Rhone-Poulenc
Dr Renzo Mattlussl, Montedison
Mr M Bonnefoy, Solvay
Dr B List, Lonza
Mr P G Claus, AFME
Dr J C Kammuller, Shell
Dr L de Boer, Shell
Mr S WeJdling, Kemanord
Mr C Rangnes, Norsk Hydro
Dr Terwiesch, CW11
Mr H Emmlnger, VKE
Mr P de Voogd, Shell
Dr E Lloyd-Jones, BP
Mr Owen Jones, Mlllhouse
Dr Brian Bennett, Hlllhouse
Dr Peter Wright, PCD Wilton
Dr F W Best, Everberg
Dr G Morcross, Everberg
Mr C DMlaenens, APME
Dr C Bishop, EMAS
Mr B Werner, EMAS
Dr Spirtas - NIOSH, Clnclnatti
Ms R Kaminski " N10S1I, Cinclnattl
AECl,
Duperial)
Dr J Stafford (8)
URL 00930
^
Dr T R Torkelson, Dow l)v^ l12, Mr J Lawrence, SP1
W'4lr J T Seavell, CMAWashington
Mr R N Wheeler, UCC Dr A Ross Adams, Air Products Dr Mayo Smith, Air Products
V-., ^
-< , *1 O
tO
^ ^
. to
CD
O
1
Dr John Rarr, Air Products Dr Walter D Harris, Uniroyal Inc Dr Robert K Hlnderer, BF Goodrich (Cleveland) Dr R A Krueger, BF Goodrich Dr M N Johnson, BF Goodrich Dr J Possberg, VJacker Dr J Rety, RP, St Fons Dr P Lazard, RP, St Auhan Dr I A Frledel, Berufsgenossenschaft der chcmiachen
Industrie, Heidelberg
Prof Dr Thless, BASF Dr D M Ferguson, IC1 Americas Mr D Ryerson, 1CI Americas Mr A J Wheeler, 1C1 Americas Mr M J S Gibbons ICI Americas Dr Cary Ter Haar, Ethyl Corporation Prof* C Maltoni, Bologna Dr J William Lloyd, Osha Dr David Bryson, AG Division Mr S Nakamura, Japanese PVC Association Dr Peter Baxter, CPC Atlanta
JS/UJT/D-58 l May 1980
t
Table Sequence
Relglum
Canada
Czechoslovakia
France
Germany
Italy
Japan
Norway
Sweden
UK
USA
Yugoslavia
Incidence of Cases pa (Table I)
Distribution of Cases
by Country
(Table 2)
Pattern of Cases by
Factory
(Table 3)
Latency Periods (Table 4)
Annual Geographical Incidence (Table 5)
URL 00931
IMPERIAL CHEMICAL INDUSTRIES LIMITED
plastics Division
LIVER ANGIOSARCOMA CASES (REVIEW DATA - 1 MAY 1980)
Acknowledgements Significant Changes & Comments
1 I Page II - German Case 13 - In the 8 January listing 1 did not notice a typographical error. This man was born 1904 and
2-3 not 1914. Tills error is corrected In the present Issue.
4 5-7 8-11 12 13 14 15 16-17 18-22 23 24
25
26
27 28
2 At the OSIIA/NIOSH/N1EHS Symposium at Bcthesda on 20/21 March 1980 Dr H WEBER of Der Staatliche Cewerbearzt stated that there were now 17 confirmed ASL cases In W Germany* I presume cases 13 and 14 are now histologically confirmed. Perhaps Dr Frledel or Mr Emminger would care to comment and also give me the data I don't yet have on case 14.
3 In the 6 January Issue, I commented that, after a long Interval without any cases, the UK had had two new cases bringing the total to 4* This total unfortunately became five on 9 January! It Is curious that the five UK cases should have occurred 1 in 1972, 1 in 1974, 2 late In 1979 and 1 early 1980.
4 As a continuation of the above point 3, no one has commented to me on Table 5 and the geographical split of ASL deaths. I would repeat my questions. Have North American ASL deaths tapered off? Or is this just a temporary lull? Are West European ASL death rates Increasing? North America started to have ASL deaths a decade before W Europe. Has North America peaked out and (hopefully) finished before W Europe*
5 We still do not have any answers to the bizarre clustering of cases in certain factories* Even the distribution of "clusters" Is peculiar. Table 3 confronts us with the question why so few plants In N America have been affected while the ASL cases are more evenly and broadly distributed over W Europe plants*
J STAFFORD Division Manager Health and Environment Protection ICI Plastics Division Bessemer Road Welwyn Garden City Hertfordshire
URL 00933
1HPERIAL CMQHCAL industries LIMITED PLASTIC! OtVISION
LITER ln|lMirCNi Cam - (Rovlaw !*Ul 1 hj 1900)
* All late* oae UK t^itta
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PAT - MONTH -TEAR
Sheet |
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Occ M IRIS ri|e 338-340
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1941 1941
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PLASTICS DIV1SIAM
U V U I A L CnCHfCAL INDUSTRIES LIM ITED
LITER Angloaarcoaa Caaaa - (Review D atoi 1 Ih y 1900)
- -M T MONTH TEAK
Sheet 2
p i t l l i M* A ll Aatea uea UK eyatea
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Page J
URL 00936
IMPERIAL CHEMICAL INDUSTRIES LIMITER PLASTICS DIVISION
LIVER Aoflooorcono Caooo * (Rovlo* Datoi 1 Ihj i960)
Fraaco Him! I
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URL 0093?
IMPERIAL CHEMICAL lltlMISTRIF.S LIH1TEO PLASTICS DIVISION
LITRE AailturcMi Caaaa - (Ravlev Datet t Ihy 1J80)
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URL 00938
IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS niVtSlOM
LIVER AngiHircoa* (net - (Re|w Betel 1
1J0O)
France Sheet 3
Pat# 7
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URL 00940
inprrial chemical industries uniter
ELASTICS DIVISION
Cihi * (Ravlaw Datat 1 Hay tJBO)
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COUNTRY AND
reference
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21
21
13.11.75 I
Taa
(NIOSN
aaya 12)
08
00.00.17 Oynaalt Trol*4orf | 19.07.54 08.04.79 I 90
22
21 (25.12.79
Ta*
II
I
JI
jrvc - Haaa-
((aetata IShlft LaaOar
I I
(FVC HamrI factor* a*4 (all work (incl awto(cleaalng
(12 yra
1(1954-88) (Faraaaa Tack (Rev 8 yra 1(1987-1973)
I T---------------
(Falfwarkar
I
URL 00941
INPER1AL CHEMICAL INDUSTRIES UNITKR mimci Diviaion
USER ta|lMtrt*M Ceeee - (Review (tatci 1 Hay 1)60)
CtrMitf Sheet 3
Page 10
COUNTRY AND REFERENCE NO
CKRMANI
09
NAME DR INITIALS
DATS OP )
sitm I I
COWANT
I I
00.00.34 | cm
I 1
I
| PACTOST
I
4
FIRST TC exposure
11
---------------------- (---------------------------------- 1-----------------1
7
1 1
9
10
1IJ_________1 __________________
,
i
;n
1
DAT! OP I ACH AT | TEARS OP DIAGNOSIS ( DIAGNOSIS | RXPOSURR TO
( 1 DIAGNOSIS
TKARS OP EXPOSURE
DATE or ( HISTOLOGICAL | ESTIHATRD DEATH 1 CONFIRMATION j EXPOSURE
1 | LEVEL
!-------------------------- !
________________ ! ______________ 1________________________1________________
14 OCCUPATION
II
I
I
11(Marl
j 10.01.41
14.04.74 |
4|
13
14.03.74
Tee
High peek* 11 yre pelf
II
I
(worker teeI
tI
(lit awte-
Icleee
Irleaeleg
!I
IControl
1 yr
1
13 It
OTIIBB CAREER
mCHLICHTS
| j
j
OTHER COtMENTS
10/70 ConllrecO Average eapeeere IIret * pro 130 ppe, ecc >1000 ppa. iNeet 1 pro a*, |73 ppe. Laet.
yr ae 33 ppe
10 (NIOSN gleee
aa Ceee ll)| I I I
oo.oo.i4 I cm
(Marl
01.01.41
00.01.71 | I
40
It
10 07.03.77 |
Tee
(High peek* (10 yre poly1 |worker lael
1171 awteIclave (cleaning
Average eapeewre (Iret 9 yra 130 ppe. (ecc 1000 ppe. (Lent yr av 173 ppe. cm
letter el 21.04.70
II I 2200.07.29 Meeker
(ierg-
10.10.33 20.04.77 |
47
22 20.04.77 | Tee
High
|l yre ante-
(Niosn gtveel
Ikeueee
I
I jelave
ae Cnee IO)(
I I (cleaner
II
(19 yre
II
(niter
II
(operatar
12
00.00.34 Dyeaelt |Trele4orf 00.00.41 00.10.77 |
39
14
I
II
I
07.10.77 | I I
Tee
(PTC tfaauIfactwra (Aetoclave Iwerkar far (4 yre
I
URL 00942
iiipcriai. chemical itnmsTRiEn lihiteo pi-astics division
LIVER AfljtliMurcoH Dines - (Review IVito I liny, 1990)
ttcrtuiny Sheet 4
rage 11
11
I2
1
)
icountry and
I REFERENCE
| NO
iiame or
INITIALS
hath or niRTii I
1
4 CnilPAIIY
1 15 1 1 1
I FACTORY
1
X X X J_
1 91
1 1
FIRST VC |
7 IMTT OF
EXPOSURE | DIAGNOSIS
1
_________ L
R9
ACT. AT
YFARS OF
DIAGNOSIS EXPOSURE TO
DIAGNOSIS
X
ID
TEARS OF
EXPOSURE
II
DATE OF DEATH
12
HISTOLOGICAL COIIFf RIIATIOII
1 n 1* 1 15 1 IA
estihati:o
EXPOSURE
1J.VEL
OCCUPATION |
X
1
OTHER
CAREER 1
IIICIILIGirrS
I1TIIER
COHItNTS
JL_
Germany
1
n1
1
1 11
I1
loo.no.oA
Lanza
lUaldshst | 00.00.60 OR.OA.7B |
64
10
l 11
11
1 ii
1 14
119.05.78 |
1 11
Ho*
1 . .. 1
11
11
1 11
1 IA 1
i
100.00.27
CUII
1 lllnrt
1 | 03.12.56
1
t death! |
51!
1 1
22!
1 1 17
11
|129.07.76
llo*
11
11
11
11
11
11
11 11
1I
11
1 11 1 11
15 1
|on.o0.29 Uacker
1 Burghattsen 19.10.53 09.10.78 |
49
1
25
|1 20 123.10.78
Tea
11
11
11
1 (VKI aaral
1
11
11
1
1 25)
1
1
1
11
11
1 11
11
11
1
1 t1
I1
11
11
1 11
11
11
1
1 11
11
11
1|
1 11
1 16 1
1 fon.no.13
Oynaalt
11 ITrotadarf| 10.01.55
1
07.0t.78 |
44
1 11
23
1 20 107.08.78 |
Tes
1
1 1 1 1 1 |7 1 1 1
1
I
I 11
1
1 11
1
1 11
1
1 11
11
1 11
1
1 11
11
100.00.37
Oynantt
ITraledorfl 01.11.61
14. (It. 78 |
41
16
1 11
1
1 11
1
1 11
1 11
1
1 11
11
1 11
1 11
1 t1
1 11
1 11
1 11
1 II
128.08.78 |
1 11
1 11
1 11
1 tI
1 11
Yes
11
11
i I1
11
1
1
11 11
11
11
11
1 1_J________
11 11 11 |1 f1 11 11 11 11 _J1!
11 1 1 11 1 1 11 11 11 11 t1
1 11 1 11 1 1t 1 11 i 11 i 11 11 i 11 i 11 i 11
t J1
11
11
1
11
1
11
|
11 11
1
11
1
|l
|
1I
1
|1 t
Autoclave
1
I (cleaner and 1
1
Iworker.
1
1
(Drier
1
1
lope rater.
1
1 lifter ahlft 1
1
Ileader
1
1t
|
11
1
1
III ah
(Autoclave
1
1 1Iworker till
1 111964.
1 1|Leader and
1 1(aaster
|1 11
|
1
1 1Hlfth
IAutoclave
1 1(worker
11
1
t1 11
1 1
11
1
No
11
1
11
1
11
1
11
(
11
1
11
1
I1
1
11
1
11
(
11
1
1 1 J___
1 |Not yet Iconlirncd
1
1
(Hot yet (confirned
1 1 lAnglosarcona (ctwif Irned ID9/79
1 1 1
1 1 lAnplosarcone |ennflrned
1 1
I
1 I lAnRloaarcona IconfIrned
1 1 1
1
1 1 1 1 1 1 1 1 1 1 1
At the NIOSII/OSMA/llfFIIR Synpoitlini In Hetheada 20/21 March IWfl Hr Ueher said there were now 17 confirned cases Is Oernany. 1 preaune cases I) and 19 are now hlstoloittcally roafIrned
J
URL 00943
IMPERIAL CMMICAI. imUSlAlRS UHITUI FUSTICS DIVISION
(.(VCR lM|t**iew Cams - ((*vtf ffcttni 1 fcj I960)
* IhwU iKI* CAM W tMMtl (fM
th* lUtl N10SH 4w It m ttwlr
tpplvwwtary (lit nliiliit t
JS IfS/It
low wrlitt*.
n* ii
COUMTRT AND REpeREftCE NO
1TALT
01
(On NIOSH npptwnttrf Ut)
I
NAME OR j DATE OF INITIALS j R1RTN
_______
\
I __
T
f COHFAMT '| FACTOR?
}
10 I u
*1
TT
MAST VC | DATS Of | ACC AT |
TSARS Of | TEARS Of j BATE Of
MTOSWAB
j OlACNOStS
j 0IACN09IS j
TORiroSORC
(
)HPOS0R8
MATH
I
I
| DIAGNOSIS j
j
-I------- 1-
15.04.94
I
I I 00,00.45 I I9.04.7t
94
I
\
I
04
12
HISTOLOGICAL CONf (RMATION
T
(3 14
ESTIMATED f EIPOSVRE | OCCUPATION
LEVEL |
(PTC N| Ititrwltr
-!-----------1-
(
T
02
II.It.29 j MMtdUnifort
I 00.00.97 ( 19.12.72
43
13
( 04 (00.12.72 t
Tm
| |Hnr|Arn
I
ItolpMittr
I
(1
<mtR CAREER RICULfCNTS
14
OTHER COMMENTS
IrlNff tlMMf
Mr k< 4*en
i*r(cn(lM.
lot 4m*'
|tMM wit4
atlwr ciHi
21 1(403
14.03.20 | Solva?
jprrrn 00.01.99 | 10.07.73
S3
22
10.07.93
1i
IAhimIhmc
I
( (l
I
|S JVR
ItotKlm
(operator
I 1*2 pro
-f-------------- 1-
-i-------b
I ______
*POA t ( *t
Mnnlk
rwridl
II
A
I 09 (14.04.ft
I I
URL 00944
IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION
LIVER Ai|lMircNi Canoe - (Review Detei f May 1900)
Page f]
COUNTRY AND RRFF.RP.NCR NO
I
T
NAME OR | DATE OP INITIALS j RIRTN
I
COMPANY,
FACTORY
JAPAH
Ol
(Tonojl | Mori
II
0t.0S.22 iHtteel iToatew
Noya
I (no coanont
(by Jap PVC I
lAeeec)
I
I
I FIRST PC I DATE OP tXPOSURR | DIAGNOSIS
I
00.04.53 | 24.10.2) I
10 II
I------------------- 1-------------- 1---------
ACE AT
| TEARS OP | TEARS OP ) DATE OP
DIAGNOSIS I BKPOSORE TO j EXPOSURE | DEATR
I DIAGNOSIS I
II
1
I
I
53 22
I) {24.10.25
I
02 Iso
02.OS.39 | I I
00.It.50 i 10.00.76
I I I I
_________I__________ |
37
17 | 13 il0.00.76
12 13 14
IS
I
16
HISTOLOGICAL ) ESTIMATED j
)
CONFIRMATION ) EXPOSURE I OCCUPATION j
| LEVEL j
|
I
7
II tI
I I
Tee
IPTC Aeeec |I3 fra aato-l
leave net (clave
|
Iknown.
fcleener
I
I* Japan
IIV44 -
|
iTInee
{evelgneA to |
|ln4lcit(A (different
Ion 2S.10.?5|vork olnce
leepoenree (had 111
jofton at
ikeattb
(3000 ppn wpj
Ito 1974
|
I --___ I___________
OTHER
CAREER HIGHLIGHTS
j OTHER | ComeNTS I
Japan Tinea 25.10.25 6 Jepaneee PTC Aaaec letter of 31.03.71
Tee
(Net known
|In polynar- j
llastloo werk| jlaclodlag |
lavtoclave (donning
| (
II
Japan*oe PVC Aeaaclotion Iletter of III.03.70
jstilaoo | Sato
Shlgeo Tanaka
------------------------- J----------------
Buk-
(Nagoya
contrectorl
to Ml tool |
Tootan
j
I
Hltaul Toataw
I Nagoya
CASES NOT YET CONFIRMED
TOT
Nov lit!
IT
IT
li.oi.H
1-----------------------
|Reactor (cleaner (1964-1974
1 ( 1
Recwyoohl I
Ono
j
f 1 11
1 1 1 -----------1---------------------
I Mltanl I Toatan ( | _______ 1______________
1 1 1 1
(Nagoya 1 f
1
1 1 1 |
| 1 1
1
11
i
11
i
11
i
i-------------------- "i-------------------------------- 1------------------------
\I i1
1 ---------------------- 1----------------- ----------------- 1
Dec 1967
1 1
47
i i
1 | 11 |
1 J_____________ _J__________
i i i i \
Dae I967| 1 1 1 1
1 1 1 1 1
1 1 | j
1
1 1 1
1 1
I i i
1 i
T--------------------------------
|Pre-cancerowo jdlnordor of
Iliver jjapee Tinea
I2S.ID.7S net (confined kjr
Jap PVC Aeeoc lapen Tinea (27.10.75 (ciom (flgarea Uncertain kaA (print). Not (eonflrned ky (jao PVC Aaaoe 1
(Japan Tlnec l27.IO.7S. Not (conflrnad ky |Jap PVC Aaaoe
1
URL Q0945
IHPRRIAL CHEMICAL INDUSTRIES LIMITED plastics division
LIVEN tailMirccM Coeee * (Review Dotet 1 Hay 1990)
I
rt t*
COUNTRT ANN I NAME OR I DATE Of } REFERENCE I INITIALS | IINTO I NO
CONTANT
NORWAY ni
Ian
21.12.15 ) Neroh
I Hydro
I fIRST VC FACTORT BXrOSURI
MTS or DIAGNOSIS
NerofR
00.05.50 21.12.71
ACE AT DIAGNOSIS
51
10 IK It 1) H
15
I
TRASS or i TSARS Of
EXPOSURE TO | EXPOSURE
01ARNOSIB I
DATE OP
NISmORICAL I ESTIMATED j
I
DRAIN I CONFIRMATION EXPOSURE
OCCUPATION I
I
ILEVEL
I
______ I
OTNER CAREER DIRHLICtfTS
II
1 II
22 21 01.01.72 |
Tee
I Nigh
|PTMn I
I lAeteclove J I jwHwwrvtMr
I
I
I
II
OTHER COMMENTS
ctAdrwj hp
Pr ThlloInm of NN. At APMR Nt| of 9 June 1978 Mr P Rongooo toted thot AN hod hven o oeoher of o urt*F too*. TCH A PVC wore Ml* li HN Utilising. The VCH weo froe ecetpleoe
URL 00946
IMPERIAL CHEMICAL INDUSTRIES LtNITCD PLASTICS OlftltOR
LIVED A|lenrcM Caeea - (Review total 1 hf i960)
Peg* IS
CnUKTRT AND 1 REFERENCE I NO
NAME OR INITIALS
DATE OP BIRTH
COHPANT
I ----- p-
f1
I
( | PIDST VC | MTV OP | ACE At
I PACTORT I UrOSURK | DIACNOSIS | DIACNOSIS
till -i-------------- 1-
NU
02 IL
JI.04.J/ Keaeeerd 27.tl.ll | Kanrd
(Suadevallj 14.OS.St | 20.10.70
j-------------- 1
ISwadevallt 00.01.AS | 00.0S.I2
I
I
|
43
41
II
10 II IZ 13 14
IS
14
TEARS Of EIPOSURE TO
DIACNOSIS
IV
| TEARS OP PATE OP HISTOLOGICAL \ ESTIMATED i
| EXPOSURE | MATH I CONFIRMATION | EXPOSURE | OCCUPATION
||
LEVEL I
____ 1 I
II II IS (20.10.70 (
Tea
IPolyworker {
OTHER CAREER BICNLICtfTS
OTHER
COWiENn
27
27 114.00.72 I
Tea
Hlgli IVCN
I |productloa
I
|nr SJoella'e jletter el
(SB Merck 1970 Icoaflrae SL (vae a annoaer (worker who mi jkaaellT
(eapoeed. Iprohekly even (aara ao than
1a normal reactor leleaner
0) NX
04 AL
|I0.04.10 Reaaaord SunJaeallt OO.OS.47
-------- rI
I
114.11.14 ( EeaaaorA (Suiwlavalll 00.00.44
(
IB.0S.74 |
I
12.05.77 |
45 44
IV
21 (IV.OS.74
Taa
Hlgli
Poljrworker
I
SI ( St (12.05.77 I
Tea'
I EtgK
11944-1950
II
jpolyoerllaatloa
Iwerker (It I
(yra> 4 195S-I |lV77 fereaenl
1(19 pra)
|
I!
II
II
II
(la ftret 12
Ijermeplaoyfment
keen heavily (aapoaed. la 1(974, liver jebnoraalltr
iand aecroata dlagnaaed. (Data confirmed (la Dr D Byrea {latter IS.8.77
(to curie
URL 00947
inrnui chemical industries limited N.ASTICS DIVISION
LIVER AR|lHrewi Geeee - (Review Detei 1 Ihy 1?0O
me
Sheet I
Pe* 16
I COtfNTHT AND I
reference |
NO I
NANS OR J
initials
rI
DATS or I BIRTH I I
COHrANT
UK
01
MJ
I
I 20.04.01 | lei
II
J------ 1- I
*
I I rust vc I datc or | acs at
I ractorr | ixposurs i niACNosis I diagnosis
till
!_________ I___________
1------------- 1-------------
1I
II
Itdlttiowoef 04.04.44 03.1X.7X I
71
II
(ret 6
|
Osltler |
I rarer urij
2X.IX.7X) |
03 BIN
j02.06.37 IP I
iserrf
I
00.0X.6t
00.12.74 |
I I
37
TEARS AT EXPOSURE TO
DIAGNOSIS
28
09
10 I H
TEARS Of j DATE Of EXPOSURE j DEATH
I
12 1 |3 ----------- 1 r1--------------------------- 1
----------------------------------
14 |
19
!
1
11
HISTOLOGICAL j ESTIMATED CONFIRMATION j EXPORIIRI
1 OCCUPATION I
OTHER CAREER
1 LEVEL
I NICMLICItTS j
1(
II I
XX I01.1X.72
Tea
II o
T
I I
11944-7 VCH
I I
I
l(Po 6
)l947-S Drier}
I Collier
Ipipcr
lease
I 11446-41
I Autoclave
lorereler
23.12.72)
(194I-66 jDrier
16
OTHER COMMENTS
3.9 1X4.12.74
I I
I___________
T
Tee
I RlRh
Aetectaee
cleaner
jE*|eere
Ilotted te
2.66 - 9.69
04 JSR
(23.06.20 ICI
Nlltheweel 26.04.36 00.06.79 | 99
23
IS 11.10.79
Tee
Me4l
(54-3
Pre-war fleh
I
kith
|R*ait
pecker
II
|flent
mv^rrsrSjr
I
|33-4
vehicle
iDrler Pleat alnteeanee
156-38
1943-54
1 Autoclave
fleh eecker
|worker
156-61
IChergehenJ
(Drier
Irient
|6l-72
(Pereean
(C 2/3 Plant
URL 00948
imperial cucmcAt. umusTEirr. i.iiiitcb
plastics division
LIVER Anr,lnircMM Uh'H (Ruvtcii lintel t May I4MI)
lift
Sheet 1
Page 17
1
12
(5
|1
1
COUNTRY Atilt
IIAME OR | MATE OF
reference 1 initials i BIRTH 1
NO 1
i
X
4 COMPANY
I5
6
7| 0
| 1
1 1 FACTORY
FIRST VC EXPOSURE.
1 1
tlATT or 1 Am AT
diagnosis i DIAGNOSIS
|X X
1 1
UK
0% |K
10.01.14 BP
Barry
00.01.1! 00.10.79
69
T9lT
BP
____
Berry
____
TfeT
09.01.00
<
9 tears nr EXPOSURE Tn DIAGNOSIS
20
10
10 II
years nr EXPOSURE
DATE Or DEATH
21 19.11.79
T2 09.01.00
12
ItlSTtllOGICAt. COMriRMATlOII
15
ESTIIIATFO
exposure level
14 1 | 1 1
OCCUPATION 1 1
1991-52 Potyclcaner 1952-55 Latex 1955-60 Polyfloor 1960-64 Poly Giargehand 1964-70 Clwrgtng operator 1970-72 drier operator
Creeaer on Poly floor
15
OTHER CAREER HIGUI.IGIITS
I I 16
J__________________ I I other I coitiF.irre
l
J__________________ I l
l
I
i l f
I l I I I l I l l l I
J__________________ l l__________________ I In their (eiipplenentary | ltat nwsii lare attll
I quoting Ian
|02 fron I0C0 Iwlilch Haa heen (discounted tn |the UK. toco Inprend uny Ipolyaere (Including P9C lonto fabrics. | The UK
ICnveriment |Medical
IAdvisory (Service also |know of tvo
(further conIflrnvd ARL lease* In Iplastics (fabrication
|worker* but |lt Is dubious (whether they
lever handled IPVC
URL 00950
IMPERIAL CHEMICAL IMMISHIII LIMITER PLASTICS 0ITIS1ON
LtTM tnglHtrcsn Caoea -
Duttl f IVy 1900
*01 tgitM at 4li AAV - MONTH - TEAR
USA
Sktfl 2
h|* If
1----------------------------- 1------------------------ 1---------------------- 1---------------------------1
1
1
--------------------------- ,--------------------------------|-------------------------1---------------------- 1---------------------------------- (---------------------------1----------------------------- 1----------------------------------1--------------------------------- ,
(1
12 1 3| 4 |3|6
7
t|
f | 10 1 II |
12
| 13
|
14
|
IS
|
14 |
1 1-1______ 1
1 1i
jcOUNTRT ARO
NAHI OR | OATS OP |
| REFERENCE
INITIALS I SlRTfl |
1 MO
II
A______ ________1
11
lUSA
11
____________ 1 1
| COMPART |
__ ______ A________________ 1 r | FIRST VC
FACTO*T | CIPOSURB
II
1____________J____________ 1 1
RATE OP tIACNOStS
1 1 11 1 III
1 III
I 1
AOS AT | TEARS OP j TEARS OP | DATE OP | HISTOLOGICAL | ESTIMATED |
|
DIAGNOSIS | 8IPOSURRTO j EXPOSURE j DEATH j CONFIRMATION 1 EXPOSURE 1 OCCUPATION j
I DIAGNOSIS III
1 LEVEL 1
1
OTHER
'J
CAREER
|
NICHLtONTt 1
___________
1 1 1
1!_______ 11
1
!1111
1 r1
1
1
OTHER COtMNTS
______
1 1
| | j
1
1 1
11
1
11
11
1 of
Rajnand lot.11.31 | IPC
|Lola-
2t.OS.4S 01.03.74
43 | 2f
24 lll.03.7S
Taa
2000 ppa
|Raf 1 haa
|
Gattla- I
1 villa
11
Iwrong (Igwraa |
PlMgetf
1
|
|
1
Ira flrat
1
11 11
I1 !1
laapaanra. iLoalaallta
| j
11
11
|
11
1
1 11 11 11
iTIaaa (2t.10.74, II2.1.7S,
1(0.3.76
1 I 1
11
1
1
1---------------------- 1
I
11 11
|baf 1
1 10
II6.09-I3 | Gaadaaar |Niagara
12.06.SI OO.OS.6B
ss 1 1?
17 ll0.0S.6R
Taa
1 11
11
11
1 _________________I______________ 1 1 11
______________________ _______________________
1 11
U7.OS.Of | Caodpaar Nla*ara
14.10.46 00.03.70
61 1 23
1 23 Il6.03.70
Taa
1 Rat 1
II 1 1--------------------------- 1
1
1
1 II 1 1 11
______________________ _______________________
1 11
Prancta A Il7.lt.IB 1
Rachaan }
|
11
11
I1
11
Mraataaa
Mtaiaml 13,07.f
11 1 1
02.0S.6f
SO 20 1
1 1 1 1
1 It |O2.0S.6f 11
11 11 1t 11
Taa .
M|h 10 fra 10 ft* aa
Utllltp 6
(Rat 1 lattar
raactar ap. Saralca ap. lot 26 April
(not claanar gaggar
|l97t troa
- acparata Drpar ap.
iRwaaall A Part
craw claaaad Stripping ap. |ta J T Saawait
autoclavaa) 3 jra prlar
lot MCA
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URL 00955
Page 24
Incidence of ASL Cases Per Annum
1955 6 7
B
9 1960
1
2
3 4 5 6 7 8 9 1970
1
2 3 4 5 6 7 8 9 1980
By date of diagnosis
1
0
1
0
0
0
1
1
0
1
0
1
3 4
2
4 2 4 9 7
10
13 7 (excluding 2 Removals) 8 4 1
By date of death
1 0 1 0 0
0 1
1 0 1
0 1 1
5 3 2 3 5 6 6 11
12
8 (excluding 2 Removals)
10
4
1
Total
84 (excluding 2 Removals from US list + 2/3 vague Japanese cases)
83 (excluding 2 removals from US list + 2/3 vague Japanese cases)
N*B* 1 Does not Include Italian 01 but does Include German 03*
2 Does not include Japanese suspect cases* Since post mortem examinations are rare events in Japan, confirmation of ASL is a problem as Indeed is its discovery*
Distribution of ASL Cases by Country
URL 00956
TABLE 2
Page 25
USA Canada W Germany France Sweden Yugoslavia Italy UK Czechoslovakia Norway Belgium Japan
Total *
24 *** 10 17 ** 13
4 ess* 3 *****
2* 5 2 1 1 2 84 (allowing for 2 removals from US list due to mls-diagnosls and omitting 2/3 111
defined Japanese cases reported some years ago In Japanese newspapers)*
* Omit ItOl - atypical case of PVC bag extruder* ** Includes CEO3 aerosol can filler* *** Includes US17 - man still alive after ASL diagnosed 11.10.74 but removes Cases 24 and 25 where ASL not confirmed.
**** Includes one monomer worker* ***** Includes two monomer workers*
le*
North America Western Europe Rest of World
34 (excluding 1 alive and 2 earlier cases removed) 43 (Includes C03 aerosol can filler)
7 (excluding 2/3 suspect cases)
TABLE 3
URL 00957
Page 26
Pattern of ASL Cases by Factory
(a) W Europe
Of the A3 cases In 1) Europe* 35 have occurred In clusters at 10 factories* Of the 17 German cases, 15 have occurred In clusters at A factories*
ASL Cases
Kemanord, Sundsvall PCUK, Brignoud Dynamlt, Trolsdorf RP, St Fons Macke r, Burghausen CV/H, Marl ICI, lllllhouse BP, Barry Solvay, Tavaux Lonza, Waldshut
A 5 6 A A 3 2 3 2 2
35
(b) N America
Of the 3A cases In N America, 31 have occurred at four factories out of a total of 53 factories - In N America A6 plants have not had ASL cases*
ASL Cases
BFG, Shawlnigan BFG, Louisville UCC, S Charleston Goodyear, Niagara
10 11
6 A
31
(c) Rest of World The 7 ASL cases are believed to be in 1 cluster of 3 and 2 clusters of 2 cases
rib
URL 00958
TABLE 4
Page 27
Latency Periods (Years from first Exposure to Diagnosis)
U Europe
No of Cases
Belgium
1
France
13
Germany
17
Italy
2
Norway
1
Sweden
4
H America
UK
5 43
US 24
Rest of World
Canada
10 34
Czechoslovakia
2
Japan
2
Summary
Yugoslavia
3 7
W Europe
43
H America
34
Rest of World
7 64
Total Years 16
298 305
37 22 106 108 894
557 204 761
31 39 65 135
894 761 135 1790
Average 18 22.9 * 17*9 * 18*5 22 26.5 21.6 20*8
23*2 * 20.4 22.38
15.5 19.5 21.7 19.3
20.8 22.38 19.3 21.3
* Of the countries with> 10 cases, France and USA have average latency period above world average and Germany well below*
* I <nn - ^ f
URL 00959
TABLE 5
Page 28
Annual Incidence of ASL Cases (Pate of Death) by Geographical Area
1 1935 17 1 1961 12 14
6 7 8 9 1970 1 2 3 4 5 6 7 8 9 1980
1 1 Western Europe
1 | 1 | | |
1 11
1 |1 11 |1
14 |1
13 16 16 16 18 14 11 I *43
11 North America
1
111
111
111
111
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|
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2
1
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Rest of World
1
2 1 1 2
7
1 1 Annual Total
1 lit 111 111 111 |1|
11 11 15 13 12 13 15 16 t6 1 11 1 12 18 18 14
1 1 ` 83
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