Document QM30ad2Op8aN4112vpQvYpZ88
M m 6 - 2l>
455
V l / u a * ,, 3-273
DuPont-9478
TRADE SECRET Study Title
y^^j^^^yJ^HD aH^HurjatTtlOHapv^augbecShturdoymincRTatosxicity Volume 2 of 3
Laboratory Project ID: DuPont-9478
Test Guidelines: OUP.SP.TESPA87H0.e3a1l0th0E(1ff9e9c8ts) Test Guidelines AUTHOR: Gregory S. Ladies, Ph.D
Study Completed on: April 1,2003 Performing Laboratory: ENHEleaIk.wstkodaenurlklRP,LooDanabedtlo,darPwea.tNaOorer.eymB1foo9oux7rr1H5s40ea-a0nl0dt5hC0aonmdpEannvyironmental Sciences Work Request Number:j
Service Code Number: 3
Page 294 of 967
Company Sanitized. Does not contain TSCA CBJ
J-JJay ura.
Subchronic Toxicity avage Study in Rats
DuPont-9478
APPENDIX B INDIVIDUAL DOSE VOLUMES
-295-
Company Sanitized. Does not contain TSCA CBI
( yfUL!UaiylU ral U avageSttu9ucdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Male, I 0 mg/kg/day
654928
654993 654929 654972
654950 654953 654925 654987 654903 654966
654997 654971 654939 654919 654994
654949 654992 654909 654924 654943 654915 654927
65495.6
654910 654936
1.1 1.1 1.0 1.0 1.2 1.2 1.2 1.2
1.3 1.3 1.5 1.5 1.3 1.3 1.2 1.2 1.2 1.2
1.1 1.1 1.3 1.3 1.0 1.0 1.2 '1.2 1.2 1.2 1.0 1.0 1.1 1.1 1.2 1.2 1.1 1.1 1.2 1.2 1.1 1.1 1.3 1.3 2.1 1.2
1.0 1.0
1.2 1.2 1.1 1.1
Gavage ml.
Day 2
1.1 1.0 1.2 1.2 1.3 1.5 1.3 1.2 1.2 1.1 1.3 1.0 1.2 1.2 1.0 1.1 1.2 1.1 1.2 1.1 1.3 1.2 1.0 1.2 1.1
Gavage ml
Day 3
Gavage ml
Day 4
1.1 1.1 1.0 1.0 1.2 1.2 1.2 1.2
1.3 1.3 1.5 1.5
1.3 1.3 1.2 1.2 1.2 1.2
1.1 1.1
1.3 1.3 1.0 1.0 1.2 1.2 1.2 1.2 1.0 1.0 1.1 1.1 1.2 1.2 1.1 1.1 1.2 1.2 1.1 1.1 1.3 1.3 1.2 1.2 1.0 1.0 1.2 1.2 1.1 1.1
Gavage, ml
Day 5
1.1 1.0 1.2 1.2 1.3 1.5 1.3 1.2 1.2 1.1 1.3 1.0 1.2 1.2 1.0 1.1 1.2 1.1 1.2 1.1 1.3 1.2 1.0 1.2 1.1
Qavage ml
Day 6
1.1 1.0 1.2 1.2 1.3 1.5 1.3 1.2 1.2 1.1 1.3 1.0 1.2 1.2 1.0 1.1 1.2 1.1 1.2 1.1 1.3 1.2 1.0 1.2 1.1
Company Sanitized. Does not contain TSCA CB1
-296-
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1'.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.9 1.9 1.9 1.9 1.9 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
Jay Ural Gavage StudSyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Male, I 0 mg/kg/day
654928 1.3 1.3 654993 1.3 1.3 654929 1.4 1.4 654972 1.4 1.4 654950 1.6 1.6 654953 1.9 1.9 654925 1.6 1.6 654987 1.5 1.5 654903 1.5 1.5 654966 1,4 1.4 654997 1.6 1.6 654971 1.2 1.2 654939 1.5 1.5 654919 1.4 1.4 654994 1.2 1.2 654949 1.3 1.3 654992 1.5 1.5 654909 1.3 1.3 654924 1.4 1.4 654943 1.4 1.4 654915 1.5 1.5 654927 1.6 1.6 654956 1.3 1.3 654910 1.5 1.5 654936 1.5 1.5
Gavage ml
Day 14
1.5 1.5 1.7 1.6 1.8 2.1 1.8 1.7 1.7 1.6 1.9 1.5 1.8 1.6 1.4 1.5 1.8 1.5 1.6 1.6 1.8 1.9 1.5 1.8 1.8
Gavage ml
Day 15
Gavage ml
Day 16
1.5
1.5 1.7 1.6
1.8 .2.1
1.8 1.7 1.7
1.6 1.9 1.5 1.8
1.6 1.4 1.5
11.. 58
1.6 1.6 1.8 1.9 1.5 1.8 1.8
,
1.5
1.5 1.7
1.6 1.8 2.1
1.8 1.7 1.7
1.6 1.9 1.5 1.8 1.6 1.4
1.5 1.8
1.5 1.6 1.6 1.8 1.9
1.5 1.8 1.8
Gavage ml
Day 17
1.5 1.5 1.7 1.6 1.8 2.1 1.8 1.7 1.7 1.6 1.9 1.5 1.8 1.6 1.4 1.5 1.8 1.5 1.6 1.6 1.8 1.9 1.5 1.8 1.8
Gavage ml
Day 18
1.5 1.5 1.7 1.6 1.8 2.1 1.8 1.7 1.7 1.6 1.9 1.5 1.8 1.6 1.4 1.5 1.8 1.5 1.6 1.6 1.8 1.9 1.5 1.8 1.8
Company Sanitized. Does not contain TSCA CBI
-297-
DuPont-9478
tge ml
19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.5 1.5 1.7 1.7 1.7 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.6 1.6 1.8 1.8 1.8 1.8 1.8 2.0 2.0 2.0 2.1 2.1 2.4 2.4 2.4 1.8 1.8. 2.1 2.1 2.1 1.7 1.7 1.9 1.9 1.9 1.7 1.7 2.0 2.0 2.0 1.6 1.6 1.8 1.8 1.8 1.9 1.9 2.1 2.1 2.1 1.5 1.5 1.8 1.8 1.8 1.8 1.8 2.1 2.1 2.1 1.6 1.6 1.8 1.8 1.8 1.4 1.4 1.6 1.6 1.6 1.5 1.5 1.7 1.7 1.7 1.8 1.8 2.1 2.1 2.1 1.5 1.5 1.7 1.7 1.7 1.6 1.6 1.9 1.9 1.9 1.6 1.6 1.8 1-8 1.8 1.8 1.8 2.0 2.0 2.0 1.9 1.9 2.1 2.1 2.1 1.5 1.5 1.7 1.7 1.7 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.1 2.1 '2.1
_ay__O__ra_l_G_a_v_a_ge StupdSyuibnchRraotnsic Toxicity
INDIVIDUAL DOS VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Male, I 0 mg/kg/day
654928 654993
654929 654972 654950 654953 654925 654987 654903 654966 654997 654971 654939 . 654919 654994 654949 654992 654909 654924
654943 654915 654927
654956 654910 654936
1.7 1,7 1.8 1.8 2.0 2.4 2.1 1.9 2.0 1.8 2.1 1.8 2.1 1.8 1.6 1.7 2.1
1.7 1.9 1.8 2.0 2.1 1.7 2.1 2.1
1.7 1.7
1.8 1.8
2.0
2.4 2.1
1.9 2.0 1.8 2.1 1.8 2.1
1.8 1.6 1.7 2.1
1.7
1.9 1.8 2.0 2.1
1.7 2.1 2.1
Gavage ml
Day 26
Gavage ml
Day 27
1.7 1.7
1.8 1.8
2.0
2.4 2.1
1.9 2.0 1.8 2.1 1.8 2.1' 1.8 1.6
1.7 2.1
1.7
1.9 1.8 2.0 2.1
1.7 2.1 2.1
1.7
1.7 1.8 1.8
2.0 2.4
2.1 1.9 2.0 1.8 2.1 1.8 2.1 1.8 1.6
1.7 2.1 1.7
1.9 1.8 2.0 2.1
1.7 2.1 2.1
Gavage ml
Day 28
2.0 1.8 2.0 2.0 2.2 2.7 2.2 2.0 2.2 2.0 2.2 2.0 2.2 1.9 1.8 1.9 2.2 1.9 2.1 2.0 2.2 2.3 1.8 2.2 2.3
Gavage ml
Day 29
2.0 1.8 2.0 2.0 2.2 2.7 2.2 2.0 2.2 2.0 2.2 2.0 2.2 1.9 1.8 1.9 2.2 1.9 2.1 2.0 2.2 2.3 1.8 2.2 2.3
Gavage ml
Day 30
2.0 1.8 2.0 2.0 2.2 2.7 2.2 2.0 2,2 2.0 2.2 2.0 2.2 1.9 1.8 1.9 2.2 1.9 2.1 2.0 2.2 2.3 1.8 2.2 2.3
Company Sanitized. Does not contain TSCA CSI
-298-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
2 . 0 2.0 2.0 2.0 2.1
1.8 1.8 1.8 1.8 2.0
2.0 2.0 2.0 2.0 2.1
2.0 2.0 2.0 2.0 2.1
2.2 2.2 2.2 2.2 2.3
2.7 2.7 2.7 2.7 2.9
2.2 2.2 2.2 2.2 2.4
2 . 0 2.0 2.0 2.0 2.2
2.2 2.2 2.2 2.2, 2.4
2 . 0 2.0 2.0 2.0 1.7
2.2 2.2 2.2 2.2 2.3
2 . 0 2.0 2.0 2.0 2.2
2.2 2.2 2.2 2.2 2.4
1.9 1.9 1.9 1.9 2.0
1.8 1.8 1.8 1.8 1.9
1.9 1.9 1.9 1.9 2.1
2.2 2.2 2.2 2.2 2.3
1.9 1.9 1.9 1.9 2.0
22.. 01
2.1 2.0
2.1 2.0
2.1 2.0
2.2 2.1
2.2 2.2 2.2 2.2 2.4
2.3 2.3 2.3 2.3 2.5
1.8 1.8 1.8 1.8 2.0
2.2 2.2 2.2 2.2 2.5
2.3 2.3 2.3 2.3 2.5
yO-Day OraKjaavag^eSSttuuddiSyuibncRhraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Male, I 0 mg/kg/day
654928 2.1 2.1 654993 2.0 2.0 654929 2.1 2.1 654972 2.1 2.1 654950 2.3 2.3 654953 2.9 2.9 654925 2.4 2.4 654987 2.2 2.2 654903 2.4 2.4 654966 1.7 1.7 654997 2.3 2.3 654971 2.2 2.2 654939 2.4 2.4 654919 2.0 2.0 654994 1.9 1.9 654949 2.1 2.1 654992 2.3 2.3 654909 2.0 2.0 654924 2.2 2.2 654943 2.1 2.1 654915 2.4 2.4 654927 2.5 2.5 654956 2.0 2.0 654910 2.5 2.5 6549,36 2.5 2.5
Gavage ml
Day 38
2.1 2.0 2.1 2.1 2.3 2.9 2.4 2.2 2.4 1.7 2.3 2.2 2.4 2.0 1.9 2.1 2.3 2.0 2.2 2.1 2.4 2.5 2.0 2.5 2.5
Gavage ml
Day 39
2.1 2.0 2.1 2.1 2.3 2.9 2.4 2.2 2.4 1.7 2.3 2.2 2.4 2.0 1.9 2.1 2.3 2.0 2.2 2.1 2.4 2.5 2.0 2.5 2.5
Gavage ml
Day 40
Gavage ml
Day 41
2.1 2.1 2.0 2.0 2.1 2.1 2.1 2.1
2.3 2.3 2.9 2.9 2.4 2.4 2.2 2.2 2.4 2.4 1.7 1.7 2.3 2.3 2.2 2.2
2.4 2.4 2.0 2.0
1.9 1.9 2.1 2.1 2.3 2.3 2.0 2.0 2.2 2.2 2.1 2.1 2.4. 2.4 2.5 2.5 2.0 2.0 2.5 2.5 2.5 2.5
Gavage ml
Day 42
2.3 2.0 2.2 2.2 2.4 3.0 2.5 2.4 2.5 1.6 2.4 2.3 2.6 2.1 2.0 2.1 2.5 2.1 2.4 2.2 2.6 2.6 2.1 2.6 2.6
Company Sanitized. Does not contain TSCA CB!
-299-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
2.3 2.3 2.3 2.3 2.3 2.0 2.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 3.0 3.0 3.0 3.0 3.0 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 1.6 1.6 1.6 1.6 1.6 2.4 2.4 2.4 2.4 2.4 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.1 2.1 2.1 2.1 2.1 2.0 2.0 2.0 2.0 2.0 2.1 2.1 2.1 2.1 2.1 2.5 2.5 2.5 2.5 2.5 2.1 2.1 2.1 2.1 2.1 2.4 2.4 2.4 2.4 2.4 2.2 2.2 2.2 2.2 2.2 2 . 6 2 . 6 2.6 2.6 2 . 6
2 . 6 2 . 6 2.6 2.6 2 . 6 2.1 2.1 2.1 2.1 2.1 2 . 6 2 . 6 2.6 2.6 2 . 6
2 . 6 2 . 6 2.6 2.6 2 . 6
90-Day Oral Gavage tudyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Male, I 0 mg/kg/day
654928 654993 654929 654972 654950 654953 654925 654987
654903 654966
654997 654971 654939
654919 654994 654949
654992 654909
654924 654943 654915 654927 654956 654910 654936
2.3 2.0 2.2 2.2 2.4 3.0
2.5 2.4
2.5 1.6 - 2.4 2.3 2.6 2.1 2.0 2.1 2.5 2.1 2.4 2.2 2.6 2.62.1
2.6 2.6 .
2.3 2.1
2.2 2.2 2.4 3.0
2.6 2.4
2.5
1.9 2.5 2.4
2.8 2.2 2.1
2.3 2.6
2.3 2.4 2.3 2.7 2.7 2.2
2.8 2.6
Gavage ml.
Day 50
2.3 2.1 2.2 2.2 2.4 3.0 2.6 2.4 2.5 1.9 2.5 2.4 2.8 2.2 2.1 2.3 2.6 2.3 2.4 2.3 2.7 ' 2.7 2.2 2.8 2.6
Gavage ml
Day 51
2.3 2.1 2.2 2.2 2.4 3.0 2.6 2.4 2.5 1.9 2.5 2.4 2.8 2.2 2.1 2.3 2.6 2.3 2.4 2.3 2.7 2.7 2.2 2.8 2.6
Gavage ml
Day 52
2.3 2.1 2.2 2.2 2.4 3.0 2.6 2.4 2.5 1.9 2.5 2.4 2.8 2.2 2.1 2.3 2.6 2.3 2.4 2.3 2.7 2.7 2.2 2.8 2.6
Gavage ml
Day 53
2.3 2.1 2.2 2.2 2.4 3.0 2.6 2.4 2.5 1.9 2.5 2.4 2.8 2.2 2.1 2.3 2.6 2.3 2.4 2.3 2.7 2.7 2.2 2.8 2.6
Gavage ml
Day 54
2.3 2.1 2.2 2.2 2.4 3.0 2.6 2.4 2.5 1.9 2.5 2.4 2.8 2.2 2.1 2.3 2.6 2.3 2.4 2.3 2.7 2.7 2.2 2.8 2.6
Company Sanitized. Does not contain TSCA CBI
-300-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
2.3 2.5 2.5 2.5 2.5 2.1 2.2 2.2 2,2 2.2
2.2 2.4 2.4 2.'4 2.4
2.2 2,.3 2.3 2.3 2.3 2.4 2.5 2.5 2.5 2.5 3.0 3.2 3.2 3.2 3.2
2.6 2.7 2.7 2.7 2.7
2.4 2.5 2.5 2.5 2.5
2.5 2.6 2.6 2.6 2.6
1.9 1.9 1.9 1.9 1.9
2.5 2.6 2.6 2.6 2.6 2.4 2.5 2.5 2.5 2.5
2.8 2.8 2.8 2.8 2.8
2.2 2.1
22.. 03
22.. 03
22.. 03
22.. 03
2.3 2.4 2.4 2.4 2.4
2.6 2.8 2.8 2.8 2.8
2.3 2.3 2.3 2.3 2.3
2.4 2.5 2.5 2.5 2.5
2.3 2.3 2.3 2.3 2.3
2.7 2.8 2.8 2.8 2.8
2.7 2.8 2.8 2.8 2.8
2.2 2.3 2.3 2.3 2.3
2.8 2.9 2.9 2.9 2.9 2.6 2.7 2.7 2.7 2.7
90L-D_ay__O_r_a_l_G_a_v_a_g_e. KtujdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Male, I 0 mg/kg/day
654928 2.5 2.5 654993 2.2 2.2 654929 2.4 2.4 654972 2.3 2.3 654950 2.5 2.5 654953 3.2 3.2 654925 2.7 2.7 654987 2.5 2.5 654903 2.6 2.6 654966 1.9 1.9 654997 2.6 2.6 654971 2.5 2.5 654939 2.8 2.8 654919 2.3 2.3 654994 2.0 2.0 654949 2.4 2.4 654992 2.8 2.8 654909 2.3 2.3 654924 2.5 2.5 654943 2.3 2.3 654915 2.8 2.8 654927 2.8 2.8 654956 2.3 2.3
654910 2.9 2.9 654936 2.7 2.7
Gavage ml
Day 62
2.5 2.2 2.4 2.3 2.5 3.2 2.7 2.5 2.6 1.9 2.6 2.5 2.8 2.3 2.0 2.4 2.8 2.3 2.5 2.3 2.8 2.8 2.3 2.9 2.7
Gavage ml
Day 63
2.7 2.3 2.4 2.4 2.6 3.3 2.8 2.6 2.7 1.9 2.6 2.6 2.9 2.4 2.1 2.5 2.8 2.4 2.6 2.4 2.9 2.9 2.4 3.0 2.8
Gavage ml
Day 64
2.7 2.3 2.4 2.4 2.6 3.3 2.8 2.6 2.7 1.9 2.6 2.6 2.9 2.4 2.1 2.5 2.8 2.4 2.6 2.4 2.9 2.9 2.4 3.0 2.8
Gavage ml
Day 65
Gavage ml
Day 66
2.7 ' 2.3 2.4 2.4
2.6 3.3 2.8 2.6 2.7 1.9
2.6 2.6 2.9
2.4 2.1
2.5 2.8 2.4 2.6 2.4 2.9 2.9 2.4
3.0 2.8
2 .7 2.3 2.4 2.4 2.6 3.3 2.8 2.6 2.7 1.9
2.6 2.6 2.9 2.4 2.1
2.5 2.8 2.4 2,6 2.4 2.9 2.9 2.4
3.0 2.8
Company Sanitized. Does not contain TSCA CBI
-301 -
)
DuPont-9478
Gavage ml
Day 67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.3 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.6' 2.6 2.6 2.6 2.6 3.3 3.3 3.3 3.4 3.4 2.8 2.8 2.8 2.8 2.8 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.8 2.8 1.9 1.9 1.9 2.1 2.1 2.6 2.6 2.6 2.7 2.7 2.6 2.6 2.-6 2.7 2.7 2.9 2.9 2.9 3.0 3.0 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.3 2.3 2.5 2.5 2.5 2.6 2.6 2.8 2.8 2.8 2.9 2.9 2.4 2.4 2.4 2.5 2.5 2.6 2.6 2.6 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.9 2.9 2.9 2.9 2.9 2.9 2.9 2.9 3.0 3.0 2.4 2.4 2.4 2.4 2.4 3.0 3.0 3.0 3.1 3.1 2.8 2.8 2.8 2.9 2.9
?ay Oral Gava_g_e_S_tJuSduybicnhRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Male, I 0 mg/kg/day
Gavage ml
Day 74
654328 654993 654329 654972
654950
654353
654925 654987 654903 654966
654997 654971
654939 654919 654994 654949 654992 654909 654924
654943 654915
654927 654956 654910 654936
2.7 2.7 2.7
2.4 2.4 2.4
2.5 2.5 2.5
2.4 2.4 2.4
2.6 2.6 2.6
3-4 3.4 3.4
2.8 2.8 2.8
2.7 2.7 2.7
2.8 2.8 2.8
2.1
2.1 '
2.1
2.7 2.7 2.7
2.7 2.7 2.7
3.0 3.0 3.0
2.4 2.4 2.4
2.3 2.3 2.3
2.6 2.6 2.6
2.9 2.9 2.9
2.5 2.5 2.5
2.7 2.7 2.7
2.5 2.5 2.5
2.9 .2.9
2.9
3.0 3.0 3.0
2.4 2.4 2.4
3.1 3.1 3.1
2.9 2.9 2.9
Gavage ml
Day .75
Gavage ml
Day 76
2.7 2.4
2.5 2.4
2.6 3.4
2.8 . 2.7 2.8 2.1
2.7 2.7
3.0 2.4 2.3
2.6 2.9
2.5 2.7
2.5 2.9 3.0 2'.4 3.1 2.9
2.7 2.4 2.5 2.4
2.6 3.4
2.8 2.7
2.8 2.1 2.7 2.7 3.0 2.4 2.3 2.6 2.9 2.5 2.7
2.5 2.9
3.0 2.4 3.1 2.9
Gavage ml
Day 77
2.8 2.5 2.6 2.5 2.6 3.5 2.8 2.8 2.9 2.2 2.8 2.7 3.0 2.5 2.3 2.6 2.9 2.6 2.7 2.6 3.0 3.1 2.5 3.1 3.0
Gavage ml
Day 78
2.8 2.5 2.6 2.5 2.6 3.5 2.8 2.8 2.9 2.2 2.8 2.7 3.0 2.5 2.3 2.6 2.9 2.6 2.7 2.6 3.0 3.1 2.5 3.1 3.0
Company Sanitized. Does not contain TSCA CBI
-302-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
2.8 2.8 2.8 2.8 2.8 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 3.5 3.5 3.5 3.5 3.5 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.2 2.2 2.2 2.2 2.2 2.8 2.8 2.8 2.8 2.8 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 2.5 2.5 2.5 2.5 2.5 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.9 2.9 2.9 2.9 2.9 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 2,5 2.5 2.5 2.5 2.5 3.1 3.1 3.1 3.1 3.1 3.0 3.0 3.0 3.0 3.0
J-Uay Orai uavage StudSyuibncRhraotnsic Toxicity
INDIVIDUAL DOSE VOLUME^
Gavage ml
Day 84
Gavage ml
Day 85
Male, I 0 mg/kg/day
654928 654993
654929 654972 654950 654953 654925 654987
654903 654966 654997 654971 654939
654919 654994
654949
654992 654909
654924
654943
654915 654927 654956 654910 654936
2.9
2.5 2.6 2.5 2.6 3.5
2.9 2.9 2.9 2.3
2.8 2.8 3.1 2.5 2.3
2.7
3.0 2.6 2.7
2.6 3.1 3.1 . 2.5 3.1 3.0
2.9
2.5 2.6
2.5 2.6 3.5 2.9
2.9 2.9 2.3 2.8 2.8 3.1 2.5 2.3
2.7 3.0 2.6 2.7
2.6 3.1 3.1 2.5 '3.1 3.0
Gavage ml
Day 86
2.9 2.5 2.6 2.5 2.6 3.5 2.9 2.9 2.9 2.3 2.8 2.8 3.1 2.5 2.3 2.7 3.0 2.6 2.7 2.6 3.1 3.1 2.5 3.1 3.0
Gavage ml
Day 87
2.9 2.5 2.6 2.5 2.6 3.5 2.9 2.9 2.9 2.3 2.8 2.8 3.1 2.5 2.3 2.7 3.0 2.6 2.7 2.6 3.1 3.1 2.5 3.1 3.0
Gavage ml
Day 88
2.9 2.5 2.6 2.5 2.6 3.5 2.9 2.9 2.9 2.3 2.8 2.8 3.1 2.5 2.3 2.7 3.0 2.6 2.7 2.6 3.1 3.1 2.5 3.1 3.0
Gavage ml
Day 89
Gavage ml
Day 90
2.9
2.5 . 2.6 2.5 2.6 3.5 2.9 2.9
2.9 2.3 2.8 2.8 3.1 2.5 2.3
2.7 3.0 2.6 2.7
2.6 3.1 3.1 2.5 3.1 3.0
2.9 2.5
2.6 2.5 2.6 3.5 2.9 2.9 2.9 2.3 2.8 2.8 3.1
2.5 2.3
2.7 3.0 2.6
2.7 2.6 3.1 3.1 2.5 3.1 3.0
Company Sanitized. Does not contain TSCA CBI
-303-
Gavage ml
Day 91
Gavage ml
Day 92
2.9 2.9 2.5 2.5 2.6 2.6 2.6 2.6 2.7 2.7 3.3 3.3 3.0 3.0 2.9 2.9 3.0 3.0 2.3
2.9 2.8
3.1 2.5 2.3
2.7 3.0
2.6 2.8
2.6 3.1 3.1
2.5 3.2 3.0 3.0
)
DuPont-9478
3_-_P_a_y_O__r_a_l _G_a_v_a_g_e__St_udSyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Male, III: 1 mg/kg/day
654913 1.1 1.1 654947 1.1 1.1 654995 1.2 1.2 654938 1.3 1.3 654941 1.2 1.2 654946 1.4 1.4 654960 1.4 1.4 654908 1.3 1.3 654984 1.2 1.2 654932 1.3 1.3 654948 1.3 1.3 654904 1.2 1.2 654954 1.4 1.4 654945 1.1 1.1 654988 1.2 1.2
Gavage ml.
Day 2
1.1 1.1 1.2 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.3 1.2 1.4 1.1 1.2
Gavage ml
Day 3
1.1 1.1 1.2 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.3 1.2 1.4 1.1 1.2
Gavage ml
Day 4
1.1 1.1 1.2 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.3 1.2 1.4 1.1 1.2
Gavage ml
Day 5
1.1 1.1 1.2 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.3 1.2 1.4 1.1 1.2
Gavage ml
Day 6
1.1 1.1 1.2 1.3 1.2 1.4 1.4 1.3 1.2 1.3 1.3 1.2 1.4 1.1 1.2
Company Sanitized. Does not contain TSCA CBI
-304-
DuPont-9478
ige ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.5 1.5 1.5 1.5 1.5
w9_0_-_D_a__y_O__ra_l__G_a_v_a_g_e_S_tuIdSyubinchRraotns_ic__T_o_x_i_c_ity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Male, :til 1 mg/kg/day
654913 1.4 1.4 654947 1.4 1.4 654995 1.4 1.4 654938 1.6 1.6 654941 1.5 1.5 654946 1.7 1.7 654960 1.6 1.6 654908 1.5 1.5 654984 1.5 1.5 654932 1.6 1.6 654948 1.6 1.6 654904 1.4 1.4 654954 1.6 1.6 654945 1.2 1.2 654988 1.5 1.5
Gavage ml
Day 14
1.7 1.6 1.7 1.8 1.8 2.0 1.8 1.8 1.8 1.8 1.9 1.7 1.8 1.6 1.7
Gavage ml
Day 15
1.7 1.6 1.7 1.8 1.8 2.0 1.8 1.8 1.8 1.8 1.9 1.7 1.8 1.6 1.7
|-l CO
Gavage ml
Day 16
1.7 1.6 1.7 1.8 1-8 2.0 1.8 1.8
1.8 1.9 1.7 1.8 1.6 1.7
Gavage ml
Day 17
1.7 1.6 1.7 1.8 1.8 2.0 1.8 1.8 1.8 1.8 1.9 1.7 1.8 1.6 1.7
Gavage ml
Day 18
1.7 1.6 1.7 1.8 1.8 2.0 1.8 1.8 1.8 1.8 1.9 1.7 1.8 1.6 1.7
Company Sanitized. Does not contain TSCA CBI
-305-
)
DuPont-9478
Gavage ml
Day 19
Gavage .ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.7 1.7 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.0 2.0 2.0 2.0 2.0 2.2 2.2 2.2 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 '2.0 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.9 1.9 2.1 2.1 2.1 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.1 2.1 2.1
1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Male, I I I : 1 mg/kg/day
654913 1.9 1.9
654947 1.8 1.8
654995 1.9 1.9
654938 2.1 2.1
654941 2.0 2.0
654946 2.2 2.2
654960 2.0 2.0
654908 2.0 2.0
654984 2.0 2.0
654932 2.1 2.1
654948 2.1 2.1
66 55 44 9905 44
1.9 2.1
1.9 2.1
654945 1.8 1.8
654988 1-9 1.9
Gavage ml
Day 26
1.9 1.8 1.9 2.1 2.0 2.2 2.0 2.0 2.0 2.1 2.1 1.9 2.1 1.8 1.9
Gavage ml
Day 27
1.9 1.8 1.9 2.1 2.0 2.2 2.0 2.0 2.0 2.1 2.1 1.9 2.1 1.8 1.9
Gavage ml
Day 28
2.1 2.0 2.1 2.2 2.2 2.3 2.1 2.2 2.2 2.2 2.3 2.0 2.2 1.9 2.1
Gavage ml
Day 29
2.1 2.0 2.1 2.2 2.2 2.3 2.1 2.2 2.2 2.2 2.3 2.0 2.2 1.9 2.1
Gavage ml
Day 30
2.1 2.0 2.1 2.2 2.2 2.3 2.1 2.2 2.2 2.2 2.3 2.0 2.2 1.9 2.1
Company Sanitized. Does not contain TSCA CB
-306-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
2.1 2.0
2.1 2.0
22.. 01
2.1 2.0
2.2 2.1
2.1 2.1 2.1 2.1 2.2
2.2 2.2 2.2 2.2 2.3
2.2 2.2 2.2 2.2 2.3
2.3 2.3 2.3 2.3 2.5
2.1 2.1 2.1 2.1 2.2
2.2 2.2 2.2 2.2 2.3
2.2 2.2 2.2 2.2 2.4
2.2 2.2 2.2 2.2 2.3
2.3
2.0
2.3 2.0
2.3 2.0
22.. 03
2.4 2.2
2.2 2.2 2.2 2.2 2.4
1.9 1.9 1.9 1.9 2.0
2.1 2.1 2.1 2.1 2.2
3raTGavage jSOmSduybicnhRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Male, :III 1. mg/kg/day
654913 2.2 2.2
654947 2.1 2.1
654995
2..2 2.2
654938 2.3 2.3
654941 2.3 2.3
654946 2.5 2.5
654960 2.2 2.2
654908 2.3 2.3
654984 2.4 2.4
654932 2.3 2.3
654948 2.4 2.4
654904 2.2 2.2
654954 2.4 2.4
654945 2.0 2.0
654988 2.2 2.2
Gavage ml
Day 38
2.2 2.1 2.2 2.3 2.3 2.5 2.2 2.3 2.4 2.3 2.4 2.2 2.4 2.0 2.2
Gavage ml
Day 39
2.2 2.1 2.2 2.3 2.3 2.5 2.2 2.3 2.4 2.3 2.4 2.2 2.4 2.0 2.2
Gavage ml
Day 40
2.2 2.1 2.2 2.3 2.3 2.5 2.2 2.3 2.4 2.3 2.4 2.2 2.4 2.0 2.2
Gavage ml
Day 41
Gavage ' ml
Day 42
2.2 2.3 2.1 2.2 2.2 2.3
2.3 2.5
2.3 2.4 2.5 2.6 2.2 2.3 2.3 2.4
2.4 2.5 2.3 2.5
2.4 2.6 2.2 2.3 2.4 2.6 2.0 2.1 2.2 2.3
Company Sanitized. Does not contain TSCA CBI
-307-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
2.3 2.3 2.3 2.3 2.3
2.2 2.2 2.2 2.2 2.2
2.3 2.3 2.3 2.3 2.3
2.5 2.5 2.5 2.5 2.5
2.4 2.4 2.4 2.4 2.4
2.6 2.6 2.6 2.6 2.6
2.3 2.3 2.3 2.3 2.3
2.4 2.4 2.4 2.4 2.4
2.5 2.5 2.5 2.5 2.5
2.5 2.5 2.5 2.5 2.5
2.6 2.6 2.6 2.6 2.6
2.3 2.6
2.3 2.6
2.3 2.6
2.3 2.6
22.. 63
2.1 2.1 2.1 2.1 2.1
2.3 2.3 2.3 2.3 2.3
90-Day Oral Gavage Study in Rats Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Male, I3: 1 mg/kg/day
654913 2.3 2.4 654947 2.2 2.2 654995 2.3 2.4 654938 2.5 2.5 654941 2.4 2.4 654946 2.6 2.7 654960 2.3 2.3 654908 2.4 2.4 654984 2.5 2.5 654932 2.5 2.5 654948 2.6 2.6 654904 2.3 2.4
654954 2.6 2.7 654945 2.1 2.1 654988 2.3 2.4
Gavage ml.
Day 50
2.4 2.2 2.4 2.5 2.4 2.7 2.3 2.4 2.5 2.5 2.6 2.4 2.7 2.1 2.4
Gavage ml
Day 51
2.4 2.2 2.4 2.5 2.4 2.7 2.3 2.4 2.5 2.5 2.6 2.4 2.7 2.1 2.4
Gavage ml
Day 52
2.4 2.2 2.4 2.5 2.4 2.7 2.3 2.4 2.5 2.5 2.6 2.4 2.7 2.1 2.4
Gavage ml
Day 53
2.4 2.2 2.4 2.5 2.4 2.7 2.3 2.4 2.5 2.5 2.6 2.4 2.7 2.1 2.4
Gavage ml
Day 54
2.4 2.2 2.4 2.5 2.4 2.7 2.3 2.4 2.5 2.5 2.6 2.4 2.7 2.1 2.4
Company Sanitized. Does not contain TSCA CBI
-308-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
2.4 2.5 2.5 2.5 2.5
2.2 2.3 2.3 2.3 2.3
2.4 2.5 2.5 2.5 2.5
2.5 2. 6 2.6 2.6 2.6
2.4 2.5 2.5 2.5 2.5
2.7 2.8 2.8 2.8 2.8
2.3 2.4 2.4 2.4 2.4
2.4 2.5 2.5 2.5 2.5
2.5 2.5
2.7 2.6
22.. 67
2.7 2.6
2.7 2.6
2.6 2.7 2.7 2.7 2.7
2.4 2.5 2.5 2.5 2.5
2.7 2.8 2.8 2.8 2.8
2.1 2.2 2.2 2.2 2.2
2.4 2.5 2.5 2.5 2.5
9*0-Day.wOral Gavage S(tuJdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Male, III 1 mg/kg/day
654913 2.5 2.5 654947 2.3 2.3 654995 2.5 2.5 654938 2.6 2.6 654941 2.5 2.5 654946 2.8 2.8 654960 2.4 2.4 654908 2.5 2.5 654984 2.7 2.7 654932 2.6 2.6 654948 2.7 2.7 654904 2.5 2.5 654954 2.8 2.8 654945 2.2 2.2 654988 2.5 2.5
Gavage ml
Day 62
2.5 2.3 2.5 2.6 2.5 2.8 2.4 2.5 2.7 2.6 2.7 2.5 2.8 2.2 2.5
Gavage ml
Day 63
2.6 2.4 2.5 2.8 2.6 2.8 2.5 2.6 2.8 2.7 2.8 2.5 2.9 2.3 2.6
Gavage ml
Day 64
2.6 2.4 2.5 2.8 2.6 '2.8 2.5 2.6 2.8 2.7 2.8 2.5 2.9 2.3 2.6
Gavage ml
Day 65
2.6 2.4 2.5 2.8 2.6 2.8 2.5 2.6 2.8 2.7 2.8 2.5 2.9 2.3 2.6
Gavage ml
Day 66
2.6 2.4 2.5 2.8 2.6 2.8 2.5 2.6 2.8 2.7 2.8 2.5 2.9 2.3 2.6
Company Sanitized. Does not contain TSCA CBI
-309-
DuPont-9478
Gavage ml
Day 67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
2.6 3.6 2.6 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.7 2.7 2.8 2.8 2.8 2.9 2.9 2.6 2.6 2.6 2.7 2.7 2.8 2.8 2.8 3.0 3.0 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.8 2.8 2.8 2.9 2.9 2.'7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.5 2,5 2.5 2.6 2.6 2.9 2.9 2.9 3.0 3.0 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6
ravage tudyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Male, III 1 mg/kg/day
654913 2.7 2.7
654947 2.5 2.5
654995 2.7 2.7
654938 2.9 2.9
654941 2.7 2.*7
654946. 3.0 3.0
654960 654908
2.6 2.6
22.. 66
654984 2.9 2.9
654932 2.8 2.8
654948 2.9 2.9
654904 2.6 2.6
654954 3.0 3.0
654945 2.3 2.3
654988 2.6 2.6
Gavage ml.
Day 74
2.7 2.5 2.7 2.9 2.7 3.0 2.6 2.6 2.9 2.8 2.9 2.6 3.0 2.3 2.6
Gavage ml
Day 75
2.7 2.5 2.7 2.9 2.7 3.0 2.6 2.6 2.9 2.8 2.9 2.6 3.0 2.3 2.6
Gavage ml
Day 76
2.7 2.5 2.7 2.9 2.7 3.0 2.6 2.6 2.9 2.8 2.9 2.6 3.0 2.3 2.6
Gavage ml
Day 77
2.7 2.5 2.6 2.9 2.7 3.0 2.6 2.6 3.0 2.8 2.7 2.6 3.0 2.3 2.7
Gavage ml
Day 78
2.7 2.5 2.6 2.9 2.7 3.0 2.6 2.6 3.0 2.8 2.7 2.6 3.0 2.3 2.7
Company Sanitized. Does not contain TSCA CBI
-310-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
2.7 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.9 2.9 2.9 2.9 2.9 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3.0 3.0 2.8 2.8 2.8 2.8 2.8 2.7 2.7 2.7 2.7 2.7 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3.0 3.0 2.3 2.3 2.3 2.3 2.3 2.7 2.7 2.7 2.7 2.7
,,90-Day__Oral Gavage S_tuldSyubinchRraotnsic_T__o_x_ic_i_t_y
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Male, III: 1 mg/kg/day
654913 2.7 2.7 654947 2.5 2.5 654995 2.6 2.6 654938 2.9 2.9 654941 2.6 2.6 654946 3.0 3.0 654960 2.6 2.6 654908 2.7 2.7
654984 3.0 3.0 654932 2.9 2.9 654948 2.9 2.9 654904 2.7 2.7 654954 3.0 3.0 654945 2.4 2.4 654988 2.7 2.7
Gavage ml.
Day 86
2.7 2.5 2.6 2.9 2.6 3.0 2.6 2.7 3.0 2.9 2.9 2.7 3.0 2.4 2.7
Gavage ml
Day 87
2.7 2.5 2.6 2.9 2.6 3.0 2,6 2.7 3.0 2.9 2.9 2.7 3.0 2.4 2.7
Gavage ml
Day 88
2.7 2.5 2.6 2.9 2.6 3.0 2.6 2.7 3.0 2.9 2.9 2.7 3.0 2.4 2.7
Gavage ml
Day 89
2.7 2.5 2.6 2.9 2.6 3.0 2.6 2.7 3.0 2.9 2.9 2.7 3.0 2.4 2.7
Gavage ml
Day 90
2.7 2.5 2.6 2.9 2.6
32 ..06
2.7 3.0 2.9 2.9 2.7 3.0 ' 2.4 2.7
Company Sanitized. Does not contain TSCA
Gavage ml
Day 91
Gavage ml
Day 92
2.8 2.8 2.5 2.5 2.6 2.6 3.0 3.0 2.7 2.7 3.0 3.0 2.7 2.7 2.7 2.7 3.1 3.1 2.9 2.9 3.1 2.7
3.1
2.4 2.8
DuPont-9478
vu-uay Ural Uavage Stud[SyuibncRhraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Male, V 5 mg/kg/day
655005 1.2 1.2 654907 1.1 1.1 654980 1.1 1.1 654959 1.2 1.2 654961 1.3 1.3 654916 1.4 1.4 654911 1.3 1.3 654917 1.2 1.2 654998 1.2 1.2 654970 1.1 1.1 654926 1.3 1.3 654918 1.2 1.2 654981 1.0 1.0 654969 1.1 1.1 654967 1.1 1.1
Gavage ml
Day 2
1.2 1.1 1.1 . 1.2 1.3 1.4 1.3 1.2 1.2 1.1 1.3 1.2 1.0 1.1 1.1
Gavage ml
Day 3
1.2 1.1 1.1 1.2 1.3 1.4 1.3 1.2 1.2 1.1 1.3 1.2 1.0 1.1 1.1
Gavage ml
Day 4
1.2 1.1 1.1 1.2 1.3 1.4 1.3 1.2 1.2 1.1 1.3 1.2 1.0 1.1 1.1
Gavage ml
Day 5
1.2 1.1 1.1 1.2 1.3 1.4 1.3 1.2 1.2 1.1 1.3 1.2 1.0 1.1 1.1
Gavage ml
Day 6
1.2 1.1 1.1 1.2 1.3 1.4 1.3 1.2 1.2 1.1 1.3 1.2 1.0 1.1 1.1
Company Sanitized. Does not contain TSCA CBI
-312-
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 ' 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4
)_a_y_O__r_al__GaJvSaugbechSrtoundiyc iTnoRxiactisty
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Gavage ml
Day 14
Male, V 5 mg/kg/day
655005 1.4 1.4 1.7
654907 1.4 1.4 1.7
654980 1.4 1.4 1.7
654959
1.5
1.5
1.8
65.4961 1.7 1.7 2.0
654916 1.7 1.7 1.9
654911 1.6 1.6 1.9
654917 1.5 1.5 1.8
654998 1.6 1.6 1.8
654970 1.2 1.2 1.4
654926 1.6 1.6 1.8
654918 1.5 1.5 1.8
654981 1.3 1.3 1.6
654969 1.3 1.3 1.5
654967 1.4 1.4 1.6
Gavage ml
Day 15
1.7 1.7 1.7 1.8 2.0 1.9 1.9 1.8 1.8 1.4 1.8 1.8 1.6 1.5 1.6
Gavage ml
Day 16
Gavage ml
Day 17
1.7 1.7 1.7 1.8
2.0
1.9 1.9 1.8
1.8 ' 1.4 1.8 1.8
1.6 1.5 1.6
1.7 1.7
1.7 1.8
2.0 1.9
1.9 1.8 1.8 1.4 1.8 1.8
1.6 1.5 1.6
Gavage ml
Day 18
1.7 1.7 1.7 1.8 2.0 1.9 1.9 1.8 1.8 1.4 1.8 1.8 1.6 1.5 1.6
Company Sanitized. Does not contain TSCA CBI
-313 -
DuPont-9478
ige ml
19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.7 1.7 2.0 2.0 2.0 1.7 1.7 1.9 1.9 1.9 1.7 1.7 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 2.0 2.0 2.3 2.3 2.3 1.9 1.9 2.1 2.1 2.1 1.9 1.9 2.2 2.2 2.2 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1 1.4 1.4 1.6 1.6 1.6 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.0 2.0 2.0 1.6 1.6 1.8 1.8 1.8 1,5 1.5 1.7 1.7 1.7 1.6 1.6 1.8 1.8 1.8
90-Day _O_r_a_l G_ avage S|tQudsuybicnhRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Male, V 5 mg/kg/day
655005 2.0 2.0 654907 1.9 1.9 654980 2.0 2.0 654959 2.1 2.1
654961 2.3 2.3 654916 2.1 2.1 654911 2.2 2.2 654917 2.0 2.0 654998 2.1 2.1 654970 1.6 1.6 654926 2.1 2.1 654918 2.0 2.0 654981 1.8 1.8 654969 1.7 1.7 654967 1.8 1.8
Gavage ml.
Day 26
2.0 1.9 2.0 2.1 2.3 2.1 2.2 2.0 2.1 1.6 2.1 2.0 1.8 1.7 1.8
Gavage ml
Day 27
2.0 1.9 2.0 2.1 2.3 2.1 2.2 2.0 2.1 1.6 2.1 2.0 1.8 1.7 1.8
Gavage ml
Day 28
2.2 2.0 2.2 2.4 2.5 2.2 2.4 2.1 2.3 1.8 2.3 2.2 2.0 1.8 2.0
Gavage ml
Day 29
2.2 2.0 2.2 2.4 2.5 2.2 2.4 2.1 2.3 1.8 2.3 2.2 2.0 1.8 2.0
Gavage ml
Day 30
2.2 2.0 2.2 2.4 2.5 2.2 2.4 2.1 2.3 1.8 2.3 2.2 2.0 1.8 2.0
Company Sanitized. Does not contain TSCA CBi
- 314 -
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.2 2.2 2.2 2.2 2.2 2.4 2.4 2.4 2.4 2.4 2.5 2.5 2.5 2.5 2.5 2.7 2.2 2.2 2.2 2.2 2.3 2.4 2.4 2.4 2.4 2.6 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 23 2.4 1.8 1.8 1.8 1.8 1.9 2.3 2.3 2.3 2.3 2.5 2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.1 1.8 1.8 1.8 1.8 2.0 2.0 2.0 2.0 2.0 2.1
raj rtJuSduybinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Male, V 5 mg/kg/day
655005 2.4 2.4 654907 2.2 2.2 654980 2.4 2.4 654959 2.5 2.5 654961 2.7 2.7 654916 2.3 2.3 654911 2.6 2.6 654917 2.3 2.3 654998 2.4 2.4 654970 1.9 1.9 654926 2.5 2.5 654918 2.4 2.4 654981 2.1 2.1
654969 2.0 2.0 654967 2.1 2.1
Gavage ml
Day 38
2.4 2.2 2.4 2.5 2.7 2.3 2.6 2.3 2.4 1.9 2.5 2.4 2.1 2.0 2.1
Gavage ml
Day 39
2.4 2.2 2.4 2.5 2.7 2.3 2.6 2.3 2.4 1.9 2.5 2.4 2.1 2.0 2.1
Gavage ml
Day 40
2.4 2.2 2.4 2.5 2.7 2.3 2.6 2.3 2.4 1.9 2.5 2.4 2.1 2.0 2.1
Gavage ml
Day 41
2.4 2.2 2.4 2.5 2.7 2.3 2.6 2.3 2.4 1.9 2.5 2.4 2.1 2.0 2.1
Gavage ml
Day 42
2.5 2.3 2.6. 2.7 2.8 2.4 2.7 2.5 2.6 1.9 2.6 2.5 2.2 2.1 2.2
C o m p a n y Sanitized. Does not contain TSCA CBI
-315-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
2.5 2.5 2.5 2.5 2.5 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.4 2.4 2.4 2.4 2.4 2.7 2.7 2.7 2.7 2.7 2.5 2.5 2.5 2.5 2.5 2.6 2.6 2.6 2.6 2.6 1.9 1.9 1.9 1.9 1.9 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.2 2.2 2.2 2.2 2.2 2.1 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2
vtHDa^5raKjavageSSttuudd'SyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Gavage ml
Day 50
Male, V 5 mg/kg/day
655005 2.5 2.5 2.5 654907 2.3 2.3 2.3 654980 2.6 2.7 2.7 654959 2.7 2.7 2.7 654961 2.8 2.8 2.8 654916 2.4 2.5 2.5 654911 2.7 2.7 2.7 654917 2.5 2.5 , 2.5 654998 2.6 2.6 2.6 654970 1.9 2 . 0 2 . 0 654926 2.6 2.8 2.8 654918 2.5 2.6 2.6 654981 2.2 2.3 2.3 654969 2.1 2.2 2.2 654967 2.2 2.3 2.3
Gavage ml
Day 51
2.5 2.3 2.7 2.7 2.8 2.5 2.7 2.5 2.6 2.0 2.8 2.6 2.3 2.2 2.3
Gavage ml
Day 52
2.5 2.3 2.7 2.7 2.8 2.5 2.7 2.5 2.6 2.0 2.8 2.6 2.3 2.2 2.3
Gavage ml
Day 53
2.5 2.3 2.7 2.7 2.8 2.5 2.7 2.5 2.6 2.0 2.8 2.6 2.3 2.2 2.3
Gavage ml
Day 54
2.5 2.3 2.7 2.7 2.8 2.5 2.7 2.5 2.6 2.0 2.8 2.6 2.3 2.2 2.3
Company Sanitized. Does not contain TSCA
O
/)
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
2.5 2.7 2.7 2.7 2.7
2.3 2.5 2.5 2.5 2.5
2.7 2.9 2.9 2.9 2.9
2.7 2.9 2.9 2.9 2.9
2.8 2.5
3.0 2.6
32.. 60
3.0 2.6
3.0 2.6
2.7 2.8 2.8 2.8 2.8
2.5 2.7 2.7 2.7 2.7
2.6 2.8 2.8 2.8 2.8
2.0 2.1 2.1 2.1 2.1
2.8 2.9 2.9 2.9 2.9
2.6 2.7 2.7 2.7 2.7
2.3 2.3 2.3 2.3 2.3
2.2 2.3 2.3 2.3 2.3
2.3 2.4 2.4 2.4 2.4
TSy Oral Gavage SPtu^SdyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Male, V 5 mg/kg/day
655005 2.7 2.7 654907 2.5 2.5 654980 2.9 2.9 654959 2.9 2.9 654961 3.0 3.0 654916 2.6 2.6 654911 2.8 2.8 654917 2.7 2.7 654998 2.8 2.8 654970 2.1 2.1 654926 2.9 2.9 654918 2.7 2.7 654981 2.3 2.3 654969 2.3 2.3 654967 2.4 2.4
Gavage ml
Day 62
2.7 2.5 2.9 2.9 3.0 2.6 2.8 2.7 2.8 2.1 2,9 2.7 2.3 2.3 2.4
Gavage ml
Day 63
2.8 2.6 3.0 3.0 3.1 2.6 3.0 2.8 2.8 2.1 2.9 2.8 2.4 2.3 2.5
Gavage ml
Day 64
2.8 2.6 3.0 3.0 3.1 2.6 3.0 2.8 2.8 2.1 2.9 2.8 2.4 2.3 2.5
Gavage ml
Day 65
2.8 2.6 3.0 3.0 3.1 2.6 3.0 2.8 2.8 2.1 2.9 2.8 2.4 2.3 2.5
Gavage ml
Day 66
2.8 2.6 3.0 3.0 3.1 2.6 3.0 2.8 2.8 2.1 2.9 2.8 2.4 2.3 2.5
Company Sanitized. Does not contain TSCA
o CD
DuPont-9478
ige ml
67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
2.8 2.8 2.8 2.9 2.9 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.1 3.1 3.1 3.1 3.1 3.2 3.2 2.6 2.6 2.6 2.6 2.6 3.0 3.0 3.0 3. 3.0 2.8 2.8 2.8 2.9 2.9 2.8 2.8 2.8 2.9 2.9 2.1 2.1 2.1 2.3 2.3 2.9 2.9 2.9 3.0 3.0 2.8 2.8 2.8 3.0 3.0 2.4 2.4 2.4 2.5 2.5 2.3 2.3 2.3 2.4 2.4 2.5 2.5 2.5 2.5 2.5
J.-..U...a.....O. raFGavage SytujSayubinchRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage
ml Day 73
Male, V 5 mg/kg/day
655005 2.9 2.9 654907 2.6 2.6 654980 3.0 3.0 654959 3.1 3.1 654961 3.2 3.2 654916 2.6 2.6 654911 3.0 3.0 654917 2.9 2.9 654998 2.9 2.9 654970 2.3 2.3 654926 3.0 3.0 654918 3.0 3.0 654981 2.5 2.5 654969 2.4 2.4 654967 2.5 2.5
Gavage ml
Day 74
2.9 2.6 3.0 3.1 3.2 2.6 3.0 2.9 2.9 2.3 3.0 3.0 2.5 2.4 2.5
Gavage ml
Day 75
Gavage ml
Day 76
2.9
2.6 3.0 3.1
3.2 2..6 3.0 2.9
2.9
. 2.3 3.0 3.0 2.5
2.4 2.5
2.9 2.6 3.0
3.1 3.2 2.6 3.0 2.9
2.9 2.3 3.0 3.0 2.5 2.4 2.5
Gavage ml
Day 77
2.9 2.7 3.2 3.1 3.3 2.6 3.1 3.0 3.0 2.4 3.0 3.0 2.5 2.5 2.6
Gavage ml
Day 78
2.9 2.7 3.2 3.1 3.3 2.6 3.1 3.0 3.0 2.4 3.0 3.0 2.5 2.5 2.6
Company Sanitized. Does not contain TSCA
O 00
)
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82'
Gavage ml
Day 83
2.9 2.9 2.9 2.9 2.9
2.7 2.7 2.7 2.7 2.7
3.2 3.2 3.2 3.2 3.2
3.1 3.1 3.1 3.1 3.1
3.3 3.3 3.3 3.3 3.3
2.6 2.6 2.6 2.6 2.6
3.1 3.1 3.1 3.1 3.1
3.0 3.0 3.0 3.0 3.0
3.0 3.0 3.0 3.0 3.0
2.4 2.4 2.4 2.4 2.4
3.0 3.0 3.0 3.0 3.0
3.0 3.0 3.0 3.0 3.0
2.5 2.5 2.5 2.5 2.5
2.5 2.6
2.5 2.6
22.. 65
2.5 2.6
2.5 2.6
udyuibnchRraotnsic Toxicity
)
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Male, V 5 mg/kg/day
655005 654907 654980
654959 654961 654916 654911 654917 654998 654970 654926 654918 654981 654969 654967
3.0
2.7 3.2 3.2
3.3 2.7 3.2 .
3.0 3.1 2.4 3.1 3.1 2.6 2.5 2.6
3.0 2.7
3.2 3.2 3.3 2.7 3.2 3.0 3.1 2.4 3.1 3.1 2.6 2.5
2.6
Gavage ml
Day 86
3.0 2.7 3.2 3.2 3.3 2.7 3.2 3.0 3.1 2.4 3.1 3.1 2.6 2.5 2.6
Gavage ml
Day 87
3.0 2.7 3.2 3.2 3.3 2.7 3.2 3.0 3.1 2.4 3.1 3.1 2.6 2.5 2.6
Gavage ml
Day 88
Gavage ml
Day 89'
3.0 3.0 2.7 2.7
3.2 3.2 3.2 3.2
3.3 3.3
2.7 2.7
3.2 3.2 3.0 3.0
3-1, 3.1 2.4 2.4
3.1 3.1 3.1 3.1 2.6 2.6
2.5 2.5 2.6 2.6
Gavage ml
Day 90
3.0 2.7 3.2 3.2 3.3 2.7 3.2 3.0 3.1 2.4 3.1 3.1 2.6 2.5 .2.6
Company Sanitized. Does not contain TSCA
O CD
Gavage ml
Day 91
Gavage ml
Day 92
2.9 2.9 2.8 2.8 3.3 3.3 3.2 3.2 3.4 3.4 2.8 2.8 3.2 3.2 3.1 3.1 3.0 3.0 2.4 3.2 3.1
22.. 66 2 . 6 2.6
DuPont-9478
?_ay__O_ral Oavage~5tJuSduybicnhRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Male, VII 25 mg/kg/day
655001 1.2 1.2 654975 1.1 1.1 654922 1.1 1.1 654940 1.2 1.2 654930 1.2 1.2 654958 1.2 1.2 654952 1.4 1.4 654923 1.3 1.3 654989 1.2 1.2 655006 1.3 1.3 654920 1.1 1.1 654912 1.1 1.1 654934 1.2 1.2 654964 1.3 1.3 654933 1.2 1.2
Gavage ml
Day 2
1.2 1.1 1.1 1.2 1.2 1.2 1.4 1.3 1.2 1.3 1.1 1.1 1.2
11.. 23
Gavage ml
Day 3
1.2 1.1 1.1 1.2 1.2 1.2 1.4 1.3 1.2 1.3 1.1 1.1 1.2 1.3 1.2
Gavage ml
Day 4
1.2 1.1 1.1 1.2 1.2 1.2 1.4 1.3 1.2 1.3 1.1 1.1 1.2 1.3 1.2
Gavage ml
Day 5
1.2 1.1 1.1 1.2 1.2 1.2 1.4 1.3 1.2 1.3 1.1 1.1 1.2 1.3 1.2
Gavage ml
Day 6
1.2 1.1 1.1 1.2 1.2 1.2 1.4 1.3 1.2 1.3 1.1 1.1 1.2 1.3 1.2
Company Sanitized. Does not contain TSCA CBI
-320-
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1-5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
90-Day Oral Gavage StujSduybinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Male, VII: 25 mg/kg/day
655001 654975 654922
654940 654930 654958 654952' 654923
654989 655006
654920 654912 654934
654964 654933
1.5 1.4
1.4 1.5 1.5 1.5 1.7 1.5 1.5
1.6 1.4 1.3 1.5
11.. 55
1.5 1.4 1.4
1.5 1.5 1.5 1.7 1.5 1.5 1.6
1.4 1.3
1.5 1.5 1.5
Gavage ml
Day 14
1.7 1.6 1.6 1.7 1.8 1.6 2.0 1.8 1.8 1.8 1.6 1.5 1.7
11.. 88
Gavage ml
Day 15
1.7 1.6 1.6 1.7 1.8 1.6 2.0 1.8 1.8 1.8 1.6 1.5 1.7
11.. 88
Gavage ml
Day 16
1.7 1.6 1.6 1.7 1.8 1.6 2.0 1.8 1.8 1.8 1.6 1.5 1.7
11.. 88
Gavage ml
Day 17
1.7 1.6 1.6 1.7 1.8 1.6 2.0 1.8 1.8 1.8 1.6 1.5 1.7 1.8 1.8
Gavage ml
Day 18
1.7 1.6 1.6 1.7 1.8 1.6 2.0 1.8 1.8 1.8 1.6 1.5 1.7 1.8 1.8
Company Sanitized. Does not contain TSCA CBI
-321 -
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.7 1.7 2.1 2.1 2.1 1.6 1.6 1.9 1.9 1.9 1.6 1.6 1.8 1.8 1.8 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.1 2..1 2.1 1.6 1.6 1.8 1.8 1.8 2.0 2.0 2.2 2.2 2.2 1.8 1.8 2.1 2.1 2.1 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.0 2.0 2.0 1.6 1.6 1.9 1.9 1.9 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.9 1.9 1.9 1.8 1.8 2.0 2.0 2.0 1.8 1.8 2.1 2.1 2.1
C9t0o-Df eayJ MOraHl GHavMageSSi tiubdcyhinr oRantsi c Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Male, VII 25 mg/kg/day
655001 2.1 2.1 654975 1.9 1.9 654922 1.8 1.8 654940 1.9 1.9 654930 2.1 2.1 654958 1.8 1.8 654952 2.2 2.2 654923 2.1 2.1 654989 2.0 2.0 655006 2.0 2.0 654920 1.9 1.9 654912 1.7 1.7 654934 1.9 1.9 654964 2.0 2.0 654933 2.1 2.1
Gavage ml
Day 26
2.1 1.9 1.8 1.9 2.1 1.8 2.2 2.1 2.0 2.0 1.9 1.7 1.9 2.0 2.1
Gavage ml
Day 27
2.1 1.9 1.8 1.9 2.1 1.8 2.2 2.1 2.0 2.0 1.9 1.7 1.9 2.0 2.1
Gavage ml
Day 28
2.4 2.1 2.0 2.1 2.3 1.9 2.3 2.2 2.2 2.2 2.1 1.8 2.0 2.2 2.3
Gavage ml
Day 29
2.4 2.1 2.0 2.1 2.3 1.9 2.3 2.2 2.2 2.2 2.1 1.8 2.0 2.2 2.3
Gavage ml
Day 30
2.4 2.1 2.0 2.1 2.3 1.9 2.3 2.2 2.2 2.2 2.1 1.8 2.0 2.2 2.3
Company Sanitized. Does not contain TSCA CBI
-322-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
2.4 2.4 2.4 2.4 2.6
2.1 2.1 2.1 > 2.1 2.2
2.0
2.0
2.0
2.0 1
2.2
2.1 2.1 2.1 2.1 2.2
2.3 2.3 2.3 2.3 2.5
1.9 1.9 1.9 1.9 2.0
2.3 2.3 2.3 2.3 2.5
2.2 2.2 2.2 2.2 2.4
2.2 2.2 2.2 2.2 2.3
2.2 2.2 2.2 2.2 2.3
2.1 2.1 2.1 2.1 2.2
1.8 1.8 1.8 1.8 2.0
2.0 2.0 2.0 2.0 2.2
2.2 2.2 2.2 2.2 2.4
2.3 2.3 2.3 2.3 2.5
0 90^-DayOBraHl GHaMvaBgeBS0tSuduybcinbRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Male, VII: 25 mg/kg/day
655001
654975 654922 654940
654930 654958 654952 654923 654989 655006
654920 654912 654934 654964 654933
2.6 2.2
2.2 2.2
2.5 2.0 2.5 2.4 .2.3 2.3 2.2 2.0 2.2
2.4 2.5
2.6 2.2 2.2
2.2
2.5 2.0 2.5 2.4 2.3 2.3 2.2 2.0 2.2
2.4 2.5
Gavage ml
Day 38
2.6 2.2 2.2 2.2 2.5 2.0 2.5 2.4 2.3 2.3 2.2 2.0 2.2 2.4 2.5
Gavage ml
Day 39
2.6 2.2 2.2 2.2 .2.5 2.0 2.5 ' 2.4 2.3 2.3 2.2 2.0 2.2 2.4 2.5
Gavage ml
Day 40
2.6 2.2 2.2 2.2 2.5 2.0 2.5 2.4 2.3 2.3 2.2 2.0 2.2 2.4 2.5
Gavage ml
Day 41
2.6 2.2 2.2 2.2 2.5 2.0 2.5 2.4 2.3 2.3 2.2 2.0 2.2 2.4 2.5
Gavage ml
Day 42
2.7 2.3 2.3 2.3 2.7 2.2 2.6. 2.5 2.5 2.5 2.4 2.1 2.3 2.6 2.7
Company Sanitized. Does not contain TSCA CBI
-323-
)
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
2.7 2.7 2.7 2.7 2.7 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.3 2.7 2.7 2.7 2.7 2.7 2.2 2.2 2.2 2.2 2.2 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.4 2.4 2.4 2.4 2.4 2.1 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7
t_9_0_-D__a_y__O_ra_l__G_av__ag__e SJStuidibycihnroRnaitcs To_x_ic_i_ty___
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Male, VII 25 mg/kg/day
655001 2.7 2.8 654975 2.3 2.4 654922 2.3 2.4 654940 2.3 2.4 654930 2.7 2.7 654958 2.2 2.2 654952 2.6 2.6 654923 2.5 2.5 654989 2.5 2.5 655006 2.5 2.5 .654920 2.4 2.5 654912 2.1 2.2 654934 2.3 2.4 654964 2.6 2.7 654933 2.7 2.9
Gavage ml.
Day 50
2.8 2.4 2.4 2.4 2.7 2.2 2.6 2.5 2.5 2.5 2.5 2.2 2.4 2.7 2.9
Gavage ml
Day 51
2.8 2.4 2.4 2.4 2.7 2.2 2.6 2.5 2.5 2.5 2.5 2.2 2.4 2.7 2.9
Gavage ml
Day 52
2.8 2.4 2.4 2.4 2.7 2.2 2.6 2.5 2.5 2.5 2.5 2.2 2.4 2.7 2.9
Gavage ml
Day 53
2.8 2.4 2.4 2.4 2.7 2.2 2.6 2.5 2.5 2.5 2.5 2.2 2.4 2.7 2.9
Gavage ml
Day 54
2.8 2.4 2.4 2.4 2.7 2.2 2.6 2.5 2.5 2.5 2.5 2.2 2.4 2.7 2.9
Company Sanitized. Does not contain TSCA CBI
-324-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
2.8 2.9 2.9 2.9 2.9
2.4 2.5 2.5 2.5 2.5
2.4 2.6 2.6 2.6 2.6
2.4 2.5 2.5 2.5 2.5
2.7 2.8 2.8 2.8 2.8
2.2 2.3 2.3 2.3 2.3
2.6 2.8 2.8 2.8 2.8
2.5
2.6'
2.6
2.6
2.6
2.5 2.7 2.7 2.7 2.7
2.5 2.6 2.6 2.6 2.6
2.5 2.6 2.6 2.6 2.6
2.2 2.3 2.3 2.3 2.3
2.4 2.5 2.5 2.5 2.5
2.7 2.8 2.8 2.8 2.8
2.9 3.1 3.1 3.1 3.1
90-Day Oral Gavage__S_tu[dSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Male, VII 25 mg/kg/day
655001 2.9 2.9 654975 2.5 2.5 654922 2.6 2.6 654940 2.5 2.5 654930 2.8 2.8 654958 2.3 2.3 654952 2.8 2.8 654923 2.6 2.6 654989 2.7 2.7 655006 2.6 2.6 654920 2.6 2.6 654912 2.3 2.3 654934 2.5 2.5 654964 2.8 2.8 654933 3.1 3.1
Gavage ml
Day 62
2.9 2.5 2.6 2.5 2.8 2.3 2.8 2.6 2.7 2.6 2.6 2.3 2.5 2.8 3.1
Gavage ml
Day 63
3.1 2.7 2.7 2.6 2.9 2.4 2.9 2.7 2.8 2.7 2.7 2.4 2.6 2.9 3.2
Gavage ml
Day 64
3.1 2.7 2.7 2.6 2.9 2.4 2.9 2.7 2.8 2.7 2.7 2.4 2.6 2.9 3.2
Gavage ml
Day 65
3.1 2.7 2.7 2.6 2.9 2.4 2.9 2.7 2.8 2.7 2.7 2.4 2.6 2.9 3.2
Gavage 'ml
Day 66
' 3.1 2.7 2.7 2.6 2.9 2.4 2.9 2.7 2.8 2.7 2.7 2.4 2.6 2.9
3.2
Company Sanitized. Does not contain TSCA CBI
-325-
DuPont-9478
ige ml
67
Gavage ml
Day 68
Gavage
ml Day 69
Gavage ml
Day 70
Gavage ml
Day 71
3.1 3.1 3.1 3.2 3.2 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.6 2.6 2.6 2.6 2.6 2.9 2.9 2.9 3.0 3.0 2.4 2.4 2.4 2.4 2.4 2.9 2.9 2.9 2.9 2.9 2.7 2.7 2.7 2.7 2.7 2.8 2.8 2.8 2.8 2.8 2.7 2.7 2.7 2.7 2.7
2.7 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.5 2.5 2.6 2.6 2.6 2.6 2.6 2.9 2.9 2.9 3.0 3.0 3.2 3.2 3.2 3.3 3.3
^ 9k0-DJ ayHOraMl GavMage S}tudSyubinchRratnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Male, VII: 25 mg/kg/day
655001 654975
654922
654940 654930 654958 654952 654923 654989 655006
654920 654912 654934
654964 654933
1.2 2.7
2.8. 2.6
3.0 2.4 2.9 2.7 2.8 2.7 2.7 2.5
2.6
3.0
3.3
3.2 2.7
2.8 2.6 3.0 2.4 2.9 2.7 2.8 2.7 2.7 2.5 2.6
3.0
3.3
Gavage ml
Day 74
3.2 2.7 2.8 2.6 3.0 2.4 2.9 2.7 2.8 2.7 2.7 2.5 2.6 3.0 3.3
Gavage ml
Day 75
3.2 2.7 2.8 2.6 3.0 2.4 2.9 2.7 2.8 2.7 2.7 2.5 2.6 3.0 3.3
Gavage ml
Day 76
3.2 2.7 2.8 2.6 3.0 2.4 2.9 2.7 2.8 2.7 2.7 2.5 2.6 3.0 3.3
Gavage ml
Day 77
3.2 2.8 2.9 2.7 3.0 2.4 3.0 2.7 2.9 2.8 2.8 2.6 2.7 3.0 3.3
Gavage ml
Day 78
3.2 2.8 2.9 2.7 3.0 2.4 3.0 2.7 2.9 2.8 2.8 2.6 2.7 3.0 3.3
Company Sanitized. Does not contain TSCA CBI
-326-
DuPont-9478
Gavage ral
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
3.2 3.2 3.2 3.2 3.2 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.7 2.7 2.7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 2.4 2.4 2.4 2.4 2.4 3.0 3.0 3.0 3.0 3.0 2.7 2.7 2.7 2.7 2.7 2.9 2.9 2.9 2.9 2.9 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2-7 2.7 2.7 3.0 3.0 3.0 3.0 3.0 3.3 3.3. 3.3 3.3 3.3
90-Day Oral Gava_g_e StJudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml .
Day 84
Gavage ml
Day 85
Male, VII: 25 mg/kg/day
655001 654975 654922 654940 654930 654958 654952 654923
654989 655006
654920 654912 654934
654964 654933
3.2 2.8 2.9 2.7
3.0
2.5 3.1 2.8 3.0 2.9
2.9 2.7 2.7
3.1 3.4
3.2 2.8 2.9 2.7
3.0 2.5 3.1 2.8 3.0
2.9
2.9 2.7 2.7
3.1 3.4
Gavage ml
Day 86
Gavage ml
Day 87
3.2 2.8 2.9 2.7
3.0 2.5 3.1 2.8 3.0
2.9 2.9 2.7 2.7
3.1 3.4 '
3.2 2.8 2.9
2.7
3.0 2.5 3.1 2.8 3.0 2.9
2.9 2.7 2.7
3.1 3.4
Gavage ml
Day 88
3.2 2.8 2.9 2.7 3.0 2.5 3.1 2.8 3.0 2.9 2.9 2.7 2.7 3.1 3.4
Gavage ml
Day 89
3.2 2.8 2.9 2.7 3.0 2.5 3.1 2.8 3.0 2.9 2.9 2.7 2.7 3.1 3.4
Gavage 1 ml Day 90
3.2 2.8 2.9 2.7 3.0 2.5 3.1 2.8 3.0 2.9 2.9 2.7 2.7 3.1 3.4
Company Sanitized. Does not contain TSCA CBI
-327-
Gavage ml
Day 91
Gavage ml
Day 92
3.3 3.3 2.9 2.9 2.9 2.9 2.8 2.8 3.1 3.1 2.5 2.5 3.1 3.1 2.8 2.8 3.1 3.1 2.9 2.9
2.9 2.7
2.8
3.1
3.4
DuPont-9478
IjM90-^DMayfOJ rHalHGHavBagBe S^tuudbycihnrRoantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Male, IX 125 mg/kg/day
654983
654965 654979
654986
655003 654921
654996 654951
654955 654914 654937 654962 654982 654931
654906 654985 654978 654974
654990
654976 65957 654973 654977 654942 654991
1.2 1.2 1.1 1.1
1.1 1.1 1.2 1.2
1.2 1.2 1.3 1.3 1.4 1.4 1.2 1.2
1.2 1.2 1.2 1.2
1.2 1.2 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1.2 1.0 1.0 1.0 1.0 1.1 1.1 1.2 1.2 1.1 1.1 1.3 1.3 1.3 1.3 1.0 1:0 1.2 1.2 1.2 1.2
Gavage ml.
Day 2
1.2 1.1 1.1 1.2 1.2 1.3 1.4 1.2 1.2 1.2 1.2 1.3 1.1 1.2 1.2 1.0 1.0 1.1 1.2 1.1 1.3 1.3 1.0 1.2 1.2
Gavage ml
Day 3
1.2 1.1 1.1 1.2 1.2 1.3 1.4 1.2 1.2 1.2 1.2 1.3 1.1 1.2 1.2 1.0 1.0 1.1 1.2 1.1 1.3 1.3 1.0 1.2 1.2
Gavage ml
Day 4
1.2 1.1 1.1 1.2 1.2 1.3 1.4 1.2 1.2 1.2 1.2 1.3 1.1 1.2 1.2 1.0 1.0 1.1 1.2 1.1 1.3 1.3 1.0 1.2 1.2
Gavage ml
Day 5
1.2 1.1 1.1 1.2 1.2 1.3 1.4 1.2 1.2 1.2 1.2 1.3 1.1 1.2 1.2 1.0 1.0 1.1 1.2 1.1 1.3 1.3 1.0 1.2 1.2
Gavage
ml Day
1.2 1.1
1.1 1.2
1.2 1.3 1.4 1.2 1.2 1.2 1.2 1.3 1.1 1.2
1.2 1.0 1.0 1.1
1.2 1.1 1.3 1.3 1.0 1.2 1.2
Company Sanitized. Does not contain TSCA CBI
-328-
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.5 1-5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4' 1.6 1.6 1.6 1.6 1.6
9Q-Day Oral Gavage Study in Rats Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Male, IX 125 mg/kg/day
654983 1.5 1.5 654965 1.3 1.3 654979 1.4 1.4 654986 1.5 1-5 655003 1.4 1.4 654921 1.6 1.6 654996 1.6 1.6 654951 1.5 1.5 654955 1.6 1.6 654914 1.5 1.5 654937 1.5 1.5 654962 1.5 1.5 654982 1.4 1.4 654931 1.5 1.5 654906 1.6 1.6
654985 1.2 1.2 654978 1.2 1.2 654974 1.4 1.4 654990 1.5 1.5 654976 1.3 1.3 654957 1.5 1.5 654973 1.6 1.6 654977 1.2 1.2
654942 1.4 1.4 654991 1.6 1.6
Gavage ml
Day 14
1.8 1.6 1.6 1.7 1.7 1.9 1.9 1.7 1.9 1.7 1.8 1.8 1.7 1.8 1.9 1.4 1.5 1.7 1.7 1.6 1.8 1.8 1.4 1.7 1.9
Gavage ml
Day 15
Gavage ml
Day 16
1.8 1.6 1.6 1.7 1.7
1.9 1.9 1.7
1.9 1.7 1.8 1.8 1.7 1.8 1.9 1.4 1.5 1.7 1.7
1.6 , 1.8 1.8 1.4 1.7 1.9
1.8 1.6 1.6 1.7
1.7 1.9 1.9
1.7 1.9 1.7 1.8 1.8
1.7 1.8 1.9 1.4 1.5 1.7
1.7 1.6 1.8
1.8 1.4 1.7 1.9
Gavage ml
Day 17
Gavage ml
Day 18
1.8
1.6 . 1.6 1.7 1.7 1.9 1.9
1.7 1.9 1.7
1.8 1.8 1.7 1.8 1.9 1.4 1.5 1.7 1.7
1.6 1.8 1.8 1.4 1.7
1.9 .
1.8 1.6 1.6 1.7 1.7
1.9 1.9 1.7
1.9 1.7
1.8 1.8 1.7 1.8 1.9 1.4 1.5 1.7 1.7
1.6 1.8 1.8 1.4 1.7 1.9
Company Sanitized. Does not contain TSCA CBi
-329-
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.8 1.8 2.0 2.0 2.0
1.6
1.6 '
1.8
1.8
1.8
1.6 1.6 1.8 1.8 1.8
1.7 ,
1.7
2.0
2.0
2.0
1.7 1.7 1.9 1.9 1.9
1.9 1.9 2.1 2.1 2.1
1.9 1.9 2.0 2.0 2.0
1.7 1.7 2.0 2.0 2.0
1.9 1.9 2.1 2.1 2.1
1.7 1.7 1.9 1.9 1.9
1.8 1.8 2.0 2.0 2.0
1.8 1.8 2.0 2.0 2.0
1.7 1.7 1.9 1.9 1.9
11.. 98
11.. 98
22.. 21
22.. 21
2.1 2.2
1.4
1.4.
.1.6
1.6
1.6
1.5 1.5 1.6 1.6 1.6
1.7 1.7 1.9 1.9 1.9
1.7 1.7 1.9 1.9 1.9
1.6 1.6 1.9 1.9 1.9
1.8 1.8 2.0 2.0 2.0
1.8 1.8 2.1 2.1 2.1
1.4 1.4 1.6 1.6 1.6
1.7 1.7 1.9 1.9 1.9
1.9 1.9 2.1 2.1 2.1
Jay Oral avage"S(tju)dSyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Gavage ml
Day 26
Male, IX 125 mg/kg/day
654983 2.0 2.0 2.0 654965 1.8 1.8 1.8 654979 1.8 1.8 1.8 654986 2.0 2.0 2.0 655003 1.9 1.9 1.9 654921 2.1 2.1 2.1 654996 2.0 2.0 2.0 654951 2.0 2.0 2.0 654955 2.1 2.1 2.1 654914 1.9 1.9 1.9 654937 2.0 2.0 2.0 654962 2.0 2.0 2.0 654982 1.9 1.9 1.9 654931 2.1 2.1 2.1 654906 2.2 2.2 2.2 654985 1.6 1.6 1.6 654978 1.6 1.6 1.6 654974 1.9 1.9 1.9 654990 1.9 1.9 1-9 654976 1.9 1.9 1.9 654957 2.0 2.0 2.0 654973 2.1 2.1 2.1 654977 1.6 1.6 1.6 654942 1.9 1.9 1.9 654991 2.1 2.1 2.1
Gavage
ml Day 27
Gavage ml
Day 28
2.0 1.8 1.8 2.0 1.9 2.1
2.0 2.0 2.1 1.9 2.0 2.0 1.9 2.1 2.2
1.61.6 1.9
1.9
1.9 . 2.0
2.1 1.6 1.9 2.1
2.2 2.0 2.0 2.2
2.0 2.3 2.1 2.2 2.3 2.1 2.2 2.2 2.1
2.3 2.4 1.7
1.8 2.1 2.1
2.0 2.2 2.2 1.7 2.0 2.4
Gavage ml
Day 29
2.2 2.0 2.0 2.2 2.0 2.3 2.1 2.2 2.3 2.1 2.2 2.2 2.1 2.3 2.4 1.7 1.8 2.1 2.1 2.0 2.2 2.2 1.7 2.0 2.4
Gavage ml
Day 30
2.2
2.0 2.0 2.2 2.0 2.3 2.1 2.2 2.3 2.1 2.2 2.2 2.1
22.. 43
1.7 1.8 2.1 2.1 2.0 2.2 2.2 1.7 2.0 2.4
Company Sanitized. Does not contain TSCA CBI
-330-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage
'ml Day 35
2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.1 2.0 2.0 2.0 2.0 2.1 2.2 2.2 2.2 2.2 2.4 2.0 2.0 2.0 2.0 2.1 2.3 2.3 2.3 2.3 2.4 2.1 2.1 2.1 2.1 2.3 2.2 2.2 2.2 2.2 2.3 2.3 2.3 2.3 2.3 2.5 2.1 2.1 2.1 2.1 2.2 2.2 2.2 2.2 2.2 2.4 2.2 2.2 2.2 2.2 2.4 2.1 2.1 2.1 2.1 2.3 2.3 2.3 2.3 2.3 2.5 2.4 2.4 2.4 2.4 2.6 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.8 1.9 2.1 2.1 2.1 2.1 2.2 2.1 2.1 2.1 2.1 2.2 2.0 2.0 2.0 2.0 2.1 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.2 2.3 1.7 1.7 1.7 1.7 1.8 2.0 2.0 2.0 2.0 2.1 2.4 2.4 2.4 2.4 2.5
90-Day Oral Gavage StJuSduybinchRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Male, IX 125 mg/kg/day
654983 654965 654979 654986 655003 654921 654996
654951 654955 654914
654937 654962
654982
654931 654906 654985 654978 654974 654990 654976
654957 654973 654977
654942 654991
2.4 2.1 2.1 2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4
2.3 2.5 . 2.6 1.8 1.9 2.2 2.2 2.1 2.2
2.3 1.8 2.1 2.5
2.4 2.1 2.1
2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4
2.3 2.5 2.6
1.8 1.9 2.2 2.2 2.1 2.2
2.3 1.8 2.1
2.5
Gavage ml
Day 38
2.4 2.1 2.1 2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4 2.3 2.5 2.6 1.8 1.9 2.2 2.2 2.1 2.2 2.3 1.8 2.1 2.5
Gavage ml
Day 39
Gavage ml
Day 40
to
2.4 2.1
2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4 2.3 2.5 2.6 1.8 1.9 2.2 2.2 2.1 . 2.2 2.3 1.8 2.1 2.5
2.4 2.1 2.1 2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4
2'.3
2.5 2.6 1.8 1.9 2.2 2.2 2.1 2.2
122... 183
2.5
Gavage ml
Day 41
Gavage ml
Day 42
2.4 2.1 2.1
2.4 2.1 2.4 2.3 2.3 2.5 2.2 2.4 2.4
2.3 2.5 2.6 1.8 1.9 2.2 2.2 2.1
2.2
12.. 83
2.1 2.5
2.5 2.2 2.2
2.6 2.2 2.5 2.3 2.4
2.6 2.4 2.5 2.4
2.4 2.6 2.8
1.9 2.0 2.4 2.3
2.3 2.3
12.. 94
2.3 2.7
Company Sanitized. Does not contain TSCA CBI
-331-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
2.5 2.5 2.5 2.5 2.5
2.2 2.2 2.2 2.2 2.2
2.2 2.2 2.2 2.2 2.2
2.6 2.6 2.6 2.6 2.6
2.2 2.2 2.2 2.2 2.2
2.5 2.5 2.5 2.5 2.5
2.3 2.3 2.3 2.3 2.3
2.4 2.4 . 2.4 2.4 2.4
2.6 2.6 2.6 2.6 2.6
2.4 2.4 2.4 2.4 2.4
2.5 2.5 2.5 2.5 2.5
2.4 2.4 2.4 2.4 2.4
2.4 2.4 2.4 2.4 2.4
2.6 2.6 2.6 2.6 2.6
2.8 2.8 2.8 2.8 2.8
1.9 1.9 1.9 1.9 i:9
2.0 2.0 2.0 . 2.0 2.0
2.4 2.4 2.4 2.4 2.4
2.3 2.3 2.3 2.3 2.3
2.3 2.3 2.3 2.3 2.3
2.3 2.3 2.3 2.3 2.3
2.4 1.9
2.4 1.9
2.4 1.9
12.. 94
2.4 1.9
2.3 2.3 2.3 2.3 2.3
2.7 2.7 2.7 2.7 2.7
90-Day Oral__G_a_v_a_g_e__S_tusduybicnhRroantisc Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Male, IX 125 mg/kg/day
654983
654965 654979 654986 655003 654921 654996 654951 ,
654955 654914 654937 654962 654982 654931 654906
654985 654978 654974 654990 654976 654957 654973 654977
654942 654991
2.5
2.2 2.2 2.6 2.2 2.5 2.3 .2.4 2.6 2.4 2.5 .2.4
2.4
2.6 2.8 1.9 2.0 2.4 2.3
2.3 2.3
12.. 94
2.3 2.7
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5
2.6 2.4 2.6 2.5
2.5 2.7 2.9
2.0 2.1
2.4 2.4
2.3 2.5 2.5 2.0
2.3 2.8
Gavage ml
Day 50
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5 2.6 2.4 2.6 2.5 2.5 2.7 2.9 2.0 2.1 2.4 2.4 2.3 2.5 2.5 2.0 2.3 2.8
Gavage ml
Day 51
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5 2.6 2.4 2.6 2.5 2.5 2.7 2.9 2.0 2.1 2.4 2.4 2.3 2.5 2.5 2.0 2.3 2.8
Gavage ml
Day 52
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5 2.6 2.4 2.6 2.5 2.5 2.7 2.9 2.0 2.1 2.4 2.4 2.3 2.5 2.5 2.0 2.3 2.8
Gavage ml
Day 53
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5 2.6 2.4 2.6 2.5 2.5 2.7 2.9 2.0 2.1 2.4 2.4 2.3 2.5 2.5 2.0 2.3 2.8
Gavage ml
Day 54
2.6 2.2 2.3 2.6 2.3 2.5 2.3 2.5 2.6 2.4 2.6 2.5 2.5 2.7 2.9 2.0 2.1 .2.4 2.4 2.3 2.5 2.5 2.0 2.3 2.8
Company Sanitized. Does not c o n ta in TSCA CBI
-332-
)
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
2.6 2.7 2.7 2.7 2.7
2.2 2.2 2.2 2t 2 2.2
2.3 2.4 2.4 2.4 2.4
2.6 2.8 2.8 2.8 2.8
2.3 2.4 2.4 2.4 2.4
2.5 2.7 2.7 2.7 2.7
2.3
2.4 .
2.4
2.4
2.4
2.5 2.6 2.6 2.6 2.6
2.6 2.7 2.7 2.7 2.7
2.4 2.5 2.5 2.5 2.5
2.6 2.7 2.7 2.7 2.7
2.5 2.7 , 2.7 2.7 2.7
2.5 2.6 2.6 2.6 2.6
2.7 2.9
2.8 3.0
2.8 3.0
2.8 3.0
32.. 08
2.0 2.1 2.1 2.1 2.1
2.1 2.2 2.2 2.2 2.2
2.4 2.5 2.5 2.5 2.5
2.4 2.5 2.5 2.5 2.5
2.3 2.4 2.4 2.4' 2 :4
2.5 2.5 2.5 2.5 2.5
2.5 2.6 2.6 2.6 2.6
2.0 2.1 2.1 2.1 2.1
2.3 2.4 2.4 2.4 2.4
2.8 3.0 3.0 3.0 3.0
t 90-Day Oral Gavag_e_S_tSuucblychinroRnaictsToxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Male, IX 125 mg/kg/day
654983 654965
654979 654986 655003 654921
654996 654951
654955 654914 654937 654962 654982 654931
654906 654985 654978
654974 654990 654976 654957
654973 654977
654942 654991
2.7 2.2
2.4 2.8 2.4 2.7 2.4
2.6 2.7 2.5 2.7 2.7 2.6 2.8 3.0 2.1 2.2
2.5 2.5
2.4 ' 2.5
2.6 2.1
2.4 3.0
2.7 2.2 2.4
2.8 2.4 2.7
2.4 2.6 2.7
2.5 2.7 2.7 2.6 2.8 3.0 2.1
2.2
2.5 2.5 2.4 2.5
2.6 2.1
2.4 3.0
Gavage ml
Day 62
Gavage ml
Day 63
2.7 2.2
2.4
2.8 2.4 2.7 . 2.4
2.6 2.7 2.5
2.7 2.7 2.6 2.8 3.0 2.1 2.2
2.5 2.5 2.4
2.5 2.6
2.1 2.4 3.0
. 2.8 2.3
2.5 2.7 2.4 2.7
2.3 2.7
2.8 2.6 2.8 2.7 2.6 2.8 3.1 2.1
2.2
2.6 2.6 2.2
2.6 2.6 2.1
2.5 3.0
Gavage ml
Day 64
2.8 2.3 2.5 2.7 2.4 2.7 2.3 2.7 2.8 2.6 2.8 2.7 2.6 2.8 3.1 2.1 2.2 2.6 2.6 2.2 2.6 2.6 2.1 2.5 3.0
Gavage ml
Day 65
2.8 2.3 2.5 2.7 2.4 2.7 2.3 2.7 2.8 2.6 2.8 2.7 2.6 2.8 3.1 2.1 2.2 2.6 2.6 2.2 2.6 2.6 2.1 2.5 3.0
Gavage ml
Day 66
2.8 2.3 2.5 2.7 2.4 2.7 2.3 2.7 2.8 2.6 2.8 2.7 2.6 2.8 3.1 2.1 2.2 2.6 2.6 2.2 2.6 2.6 2.1 2.5 3.0
Company Sanitized. Does not contain TSCA
O 03
)
DuPont-9478
Gavage ml
Day 67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
2.8 2.8 2.8 2.8 2.8
2.3 2.3 2.3 2.4 2.4
2.5 2,5 2.5 2.6 2.6
2.7 2.7 2.7 2.5 2.5
2.4 2.4 2.4 2.5 2.5
2.7 2.7 2.7 2.8 2.8
2.3 2.3 2.3 2.4 2.4
2.7 2.7 2.7 2.8 2.8
2.8 2.8 2.8 2.9 2.9
2.6 2.6 2.6 2.7 2.7
2.8 2.8 2.8 2.8 2.8
2.7 2.7 2.7 2.8 2.8
2.6 2.6 2.6 2.7 2.7
2.8 2.8 2.8 2.7 2.7
3.1 3.1 3.1 3.2 3.2
2.1
2.1 '
2.1
2.2
2.2
2.2 2.2 2.2 2.3 2.3
2.6 2.6 2.6 2.6 2.6
2.6 2.6 2.6 2.6 2.6
2.2 2.2 2.2 2.4 2.4
2.6
2.6
2.6 '
2.6
2.6
2.6 2.6 2.6 2.6 2.6
2.1 2.1 2.1 2.1 2.1
2.5 2.5 2.5 2.5 2.5
3.0 3.0 3.0 3.0 3.0
90-Day Oral Gavage.Study in Rats Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Male, IX 125 mg/kg/day
654983 2.8 2.8 654965 2.4 2.4 654979 2.6 2.6 654986 2.5 2.5 655003 2.5 2.5 654921 2.8 2.8 654996 2.4 2.4 654951 2.8 2.8 654955 2.9 2.9 654914 2.7 2.7
654937 2.8 2.8 654962 2.8 2.8 654982 2.7 2.7 654931 2.7 2.7 654906 3.2 3.2 654985 2.2 2.2 654978 2.3 2.3 654974 2.6 2.6 654990 2.6 2.6 654976 2.4 2.4 654957 2.6 2.6 654973 2.6 2.6 654977 2.1 2.1 654942 2.5 2.5 654991 3.0 3.0
Gavage ml
Day 74
2.8 2.4 2.6 2.5 2.5 2.8 2.4 2.8 2.9 2.7 2.8 2.8 2.7 2.7 3.2 2.2 2.3 2.6 2.6 2.4 2.6 2.6 2.1 2.5 3.0
Gavage ml
Day 75
Gavage ml
Day 76
2.8 2.4
2.6 2.5 2.5 2.8 2.4 2.8
2.9 2.7
2.8 2.8 2.7 2.7 3.2
2.2 2.3 2.6 2.6 2.4 2.6
2.6 2.1
2.5 3.0
2.8 2.4 2.6 2.5
2.5 2.8 2.4 2.8 2.9 2.7
2.8 2.8 2.7 2.7 3.2
2.2 2.3 2.6 2.6 2.4 2.6
2.6 2.1 2.5 3.0
Gavage ml
Day 77
.Gavage ml
Day 78
2.9 2.9 2.3 2.3 2.6 2.6 2.5 2.5
2.5 2.5 2.9 2.9 2.5 2.5 2.8 2.8
2.8 2.8 2.8 2.8 2.9 2.9 2.8 2.8 2.6 2.6 2.3 2.3 3.2 3.2
1.8 1.8 2.3 2.3 2.2 2.2 2.7 2.7
2.4 2.4 2.6 2.6
2.7 2.7 2.1 2.1
2.6 2.6 3.1 3.1
Company Sanitized. Does not contain TSCA CBI
-334-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
2.9 2.9 2.9 2.9 2.9 2.3 2.3 2.3 2.3 2.3 2.6 2.6 2.6 2.6 2.6 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.9 2.9 2.9 2.9 2.9 2.5 2.5 2.5 2.5 2.5 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.8 2.9 2.9 2.9 2.9 2.9 2.8 2.8 2.8 2.8 2.8 ' 2.6 2.6 2.6 2.6 2.6 2.3 2.3 2.3 2.3 2.3 3.2 3.2 3.2 3.2 3.2 1.8 1.8 1.8 1.8 1.8 2.3 2.3 2.3 2.3 2.3 2.2 2.2 2.2 2.2 2.2 2.7 2.7 2.7 2.7 2.7 2.4 2.4 2.4 2.4 2.4 2.6 2.6 2.6 2.6 2.6 2.7 2.7 2.7 2.7 2.7 2.1 2.1 2.1 2.1 2.1 2.6 2.6 2.6 2.6 2.6 3.1 3.1 3.1 3.1 3.1
90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Male, IX 125 mg/kg/day
654983 2.9 2.9 654965 2.4 2.4 654979 2.6 2.6 654986 2.7 2.7 655003 2.6 2.6 654921 2.8 2.8 654996 2.6 2.6 654951 2.8 2.8 654955 2.7 2.7 654914 2.9 2.9 654937 2.8 2.8 654962 2.7 2.7 654982 2.5 2.5 654931 2.7 2.7 654906 3.2 3.2 654985 1.9 1.9 654978 2.3 2.3 654974 2.5 2.5 654990 2.8 2.8 654976 2.5 2.5 654957 2.7 2.7 654973 2.8 2.8 654977 2.2 2.2 654942 2.6 2.6 654991 3.1 3.1
Gavage ml
Day 86
2.9 2.4 2.6 2.7 2.6 2.8 2.6 2.8 2.7 2.9 2.8 2.7 2.5 2.7 3.2 1.9 2.3 2.5 2.8 2.5 2.7 2.8 2.2 2.6 3.1
Gavage ml
Day 87
2.9 2.4 2.6 2.7 2.6 2.8 2.6 2.8 2.7 2.9 2.8 2.7 2.5 2.7 3.2 1.9 2.3 2.5 2.8 2.5 2.7 2.8 2.2 2.6 3.1
Gavage ml
Day 88
2.9 2.4 2.6 2.7 2.6 2.8 2.6 2.8 2.7 2.9 2.8 2.7 2.5 2.7 3.2 1.9 2.3 2.5 2.8 2.5 2.7 2.8 2.2 2.6 3.1
Gavage ml
Day 89
Gavage ml
Day 90
2.9 2.4 .
2.6 2.7 2.6 2.8 2.6 2.8 2.7 2.9'
2.8 2.7 2.5 2.7
3.2 1.9 2.3 2.5 2.8 2.5 2.7
2.8 2.2 , 2.6 3.1
2.9 2.4
2.6 2.7 2.6 2.8 2.6 2.8 2.7
2.9
2.8 2.7 2.5
2.7 3.2 1.9 2.3 2.5 2.8 2.5 2.7
2.8 2.2 2.6 3.1
Company Sanitized. Does not contain TSCA CBI
-335 -
Gavage ml
Day 91
Gavage ml
Day 92
3.0 3.0 2.6 2.6 2.7 2.7 3.0 3.0 2.7 2.7 2.9 2.9 2.7 2.7 2.9 2.9 2.8 2.8 3.0 3.0
2.9 2.8 2.7
2.8
3.4 2.1
2.4
2.7 2.9
2.7
2.7
2.8 2.2
2.6 3.2
DuPont-9478
90-Day Oral Gavage SJtu^SdyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Female, II 0 mg/kg/day
655031 655107
655098 655016
655079 655036 655025 655099 655032 655083
655093 655045 655065 655074 655035 655009 655068 655019 655062
655109 655101 655072 655015 655071 655022
0.9 0.9
0.8 0.9
0.9 1.1 0.9 1.0
1.0 1.0
0.8 0.9 0.9
1.0 0.9 ' 0.9 1.0
1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
0.9 0.9
0.8 0.9
0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9
1.0 0.9 0.9 1.0
1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Gavage ml
Day 2
0.9 0.9 0.8 0.9 0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9 1.0 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Gavage ml
Day 3
0.9 0.9 0.8 0.9 0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9 1.0 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Gavage ml
Day 4
0.9 0.9 0.8 0.9 0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9 1.0 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Gavage ml
Day 5
0.9 0.9 0.8 0.9 0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9 1.0 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Gavage ml
Day 6
0.9 0.9 0.8 0.9 0.9 1.1 0.9 1.0 1.0 1.0 0.8 0.9 0.9 1.0 0.9 0.9 1.0 1.0 1.0 1.0 1.0 1.0 0.8 0.9 0.9
Company Sanitized. Does not contain TSCA CBI
-336-
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
0.9 0.9 0.9 0.9 0.9
1.0 1.0 1.0 1.0 1.0
0.9 0.9 0.9 0.9 0.9
1.0 1.0 1.0 1.0 1.0
0.9 0.9 0.9 0.9 0.9
1.2 1.2 1.2 1.2 1.2
1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.1 1.1 1.1
1.1 1.1 1.1 1.1 1.1
1.1 1.1 1.1 1.1 1.1
0.8 0.8 0.8 0.8 0.8
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.1 1.1 1.1
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.1 1.1 1.1
1.1 1.1 1.1 1.1 1.1
1.0 1.0 1,0 1.0 1.0
1.1 1.2
1.1 1.2
1.1 1.2
1.1 1.2
11.. 21
1.2 1.2 1.2 1.2 1.2
0.9 0.9 0.9 0.9 0.9
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
(X90-DajHy HOrHalHGHavBagBejjSJtSuduybcinhRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Female, II 0 mg/kg/day
Gavage ml
Day 14
Gavage ml
Day 15
Gavage ml
Day 16
Gavage ml
Day 17
Gavage ml
Day 18
655031 655107
655098 655016 655079
655036 655025 655099
655032 655083
655093 655045 655065 655074 655035 655009 655068
655019 655062 655109 V. 655101 655072 655015
655071 655022
0.9 1.0
0.9 1.0 0.9 1.2
1.0 1.1 1.1 1.1
0.8 1.0 1.0 1.1 1.0 1.0 1.1 1.1 1.0 1.1 1.2 1.2 0.9
1.0
1.0.
0.9
1.0
0.9 1.0
0.9 1.2 1.0
1.1 1.1 1.1
0.8 1.0 1.0 1.1 1.0
1.0 1.1 1.1 1.0 1.1 1.2
1.2 0.9
1.0 1.0
1.0 1.0
1.0 1.1 1.0 1.3 1.1 1.2
1.1 1.2 0.9 1.1 1.1 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.3 1.2 1.0
1.0 1.1
1.0 1.0 1.0 1.1 1.0 1.3 1.1 1.2 1.1 . 1.2 0.9 1.1 1.1 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.3 1.2 1.0
1.0 1.1
1.0 1.0.
1.0 1.1 1.0 1.3
1.1 1.2 1.1 1.2 0.9 1.1 1.1 1.2 1.1
1.1 1.2 1.2 1.2 1.2 1.3 1.2 1.0
1.0 1.1
1.0
1.0 1.0 1.1
1.0 1.3 1.1 1.2
1.1 1.2 0.9 1.1 1.1 1.2 1.1
1.1 1.2 1.2 1.2 1.2 1.3 1.2 1.0
1.0 1.1
1.0 1.0 1.0 1.1
1.0 1.3 1.1
1.2 1.1 1.2 0.9 1.1 1.1 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.3 1.2
1.0
1.0 1.1
Company Sanitized. Does not contain TSCA CBI
-337-
)
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.0 1.0 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1.2 .1.2 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 0.9 0.9 1.0 1.0 1.0 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.2 1 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.4 1.4 1.4 1.2 1.2 1.4 1.4 1.4 1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.2 1.2 1.2
90-Day Oral Gavage S__tu|dSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Female, II 0 mg/kg/day
655031 1.1 1.1 655107 1.0 1.0 655098 1.1 1.1 655016 1.1 1.1 655079 1.0 1.0 655036 1.3 1.3 655025 1.2 1.2 655099 1.3 1.3 655032 1.2 1.2 655083 1.3 1.3 655093 1.0 1.0 655045 1.2 1.2 65565 1.2 1.2 655074 1.3 1.3 655035 1.2 1.2 655009 1.2 1.2 655068 1.3 1.3 655019 1.4 1.4 655062 1.2 1.2 655109 1.2 1.2 655101 1.4 1.4 655072 1.4 1.4 655015 1.0 1.0 655071
655022 1.2 1.2
Gavage ml
Day 26
1.1 1.0 1.1 1.1 1.0 1.3 1.2 1.3 1.2 1.3 1.0 1.2 1.2 1.3 1.2 1.2 1.3 1.4 1.2 1.2 1.4 1.4 1.0
1.2
Gavage ml
Day 27
Gavage
ml Day 28
1.1. 1.0 1.1 1.1 1.0 1.3 1.2 1.3 1.2 1.3 1.0 1.2 1.2 1.3 1.2 1.2 1.3 1.4 1.2 1.2 1.4 1.4 1.0
1.2
1.3 1.1 1.1 1.2 1.1 1.4 1.3 1.3 1.3 1.3 1.0 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.5 1.4 1.0
1.3
Gavage ml
Day 29
1.3 1.1 1.1 1.2 1.1 1.4 1.3 1.3 1.3 1.3 1.0 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.5 1.4 1.0
1.3
Gavage ml
Day 30
1.3 1.1 1.1 1.2 1.1 1.4 1.3 1.3 1.3 1.3 1.0 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.5 1.4 1.0
1.3
Company Sanitized. Does not contain TSCA CBI
-338-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage
ml Day 34
Gavage
ml Day 35
1.3 1.3 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.2 1.4 1.4 1.4 1.4 1.5 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.0 1.0 1.0 1.0 1.0 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1-3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.6 1.4 1.4 1.4 1.4 1.4 1.0 1.0 1.0 1.0 1.1 1.3 1.3 1.3 1.3 1.3
C 90B-DMafyliOHraHl HGaHvaHgBe SIlt^uudybcinhRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Gavage ml
Day 38
Female, II 0 mg/kg/day
655031 1.3 1.3 1.3
655107 1.1 1.1 1.1
655098 1.2 1.2 1.2
655016 1.2 1.2 1.2
655079 1.2 1.2 1.2
655036 1.5 1.5 1.5
655025 1.4 1.4 1.4
655099
1.4
1.4 ,
1.4
655032 1.3 1.3 1.3
655083 1.4 1.4 1.4
655093 1.0 1.0 1.0
655045 1.3 1.3 1.3
655065 1.4 1.4 1.4
655074 1.4 1.4 1.4
655035 1.4 1.4 1.4
655009 1.3 1.3 1.3
655068 1.4 1.4 1.4
655019 1.4 1.4 1.4
655062 1.3 1.3 1.3
655109 1.3 1.3 1.3
655101 1.6 1.6 1.6
655072 1.4 1.4 1.4
655015 1.1 1.1 1.1
655071
655022 1.3 1.3 1.3
Gavage ml
Day 39
Gavage ml
Day 40
1.3 1.1 1.2 1.2 1.2 1.5 1.4 1.4 1.3 1.4 1.0 1.3 1.4 1.4 1.4 1.3 1.4 1.4 1.3 1.3 . 1.6 1.4 1.1
1.3
1.3 1.1 1.2 1.2 1.2 1.5 1.4 1.4 1.3 1.4 1.0 1.3 1.4 1.4 1.4 1.3 1.4 1.4 1.3 1.3 1.6 1.4 1.1
1.3
Gavage ml
Day 41
Gavage ml
Day 42
1.3 1.1 1.2 1.2 1.2 1.5 1.4 1.4 1.3 1.4 1.0 1.3 1.4 1.4 ' 1.4 1.3 1.4 1.4 1.3 1.3 1.6 1.4 1.1
1.3
1.4 1.1
1.2 1.3 1.2 1.5 1.4 1.4 1.4 1.4 1.0 1.3 1.5 1.4 1.4 1.3 1.4 1.5 1.4 1.4 1.6 1.5 1.2
1.3
Company Sanitized. Does not contain TSCA CB1
-339 -
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
1.4 1.4 1.4 1.4 1.4
1.1 1.1 1.1 1.1 1.1
1.2 1.2
1.3 f 1-3
1.2 1.3
1.2 1.3
1.2 1.3
1.2 1.2 1.2 1.2 1.2
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.0 1.0 1.0 1.0 1.0
1.3 1.3 1.3 1.3 1.3
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.3 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4 1.4
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.3
90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity
)
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Female, II 0 mg/kg/day
655031 1.4 1.3 655107 1.1 1.1 655098 1.2 1.2 655016 1.3 1.3 655079 1.2 1.2 655036 1.5 1.5 655025 1.4 1.4 655099 1.4 1.4 655032 1.4 1.4 655083 1.4 1.4 655093 1.0 1.0 655045 1.3 1.4 655065 1.5 1.5 655074 1.4 1.4 655035 1.4 1.4 655009 1.3 1.4 655068 1.4 1.4 655019 1.5 1.5 655062 1.4 1.4 655109 1.4 1.4 655101 1.6 1.7 655072 1.5 1.6 655015 1.2 1.1 655071
655022 1.3 1.4
Gavage ml
Day 50
Gavage ml
Day 51
Gavage ml
Day 52
1.3 1.3 1.3
1.1. 1.1
1.1
1.2 1.2 1.2
1.3
1.3,
1.3
1.2 1.2 1.2
1.5 1.5 1.5
1.4 1.4 1.4
1.4 1.4 1.4
1.4 1.4 1.4
1.4 1.4 1.4
1.0 1.0 1.0
1.4 1.4 1.4
1.5 1-5 1.5
1.4 1.4 1.4
1.4 1.4 1.4
1.4 1.4 1.4
1.4 1.4 1.4
1.5 1.5 1.5
1.4 1.4 1.4
1.4 1.4 1.4
1.7 1.7 1.7
1.6 1.6 1.6
1.1 1.1 1.1
1.4 1.4 1.4
Gavage ml
Day 53
1.3 1.1 1.2 1.3 1.2 1.5 1.4 1.4 1.4 1.4 1.0 1.4 1.5 1.4 1.4 1.4 1.4 1.5 1.4 1.4 1.7 1.6 1.1
1.4
Gavage ml
Day 54
1.3 1.1 1.2 1.3 1.2 1.5 1.4 1.4 1.4 1.4 1.0 1.4 1.5 1.4 .1.4 1.4 1.4 1.5 1.4 1.4 1.7 1.6 1.1
1.4
Company Sanitized. Does not contain TSCA
oCD
>
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
1.3 1.4 1.4 1.4 1.4 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.2 1.3 1.3 1.3 1.3 1.5 1.6 1.6 1.6 1.6 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.0 1.1 1.1 1.1 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.6 1.6 1.6 1.6 1.6 1.1 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4
&90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Gavage ml
Day 62
Female, II 0 mg/kg/day
655031 655107 655098 655016
655079 655036 655025 655099 655032
655083 655093 655045 655065 655074
655035 655009
655068 655019 655062
655109 655101 655072
655015 655071 655022
1.4 1.2 1.2 1.3 1.3 1.6 1.5 1.5 1.5 1.5 1.1 1.4 1.6 1.4 1.5 1.4 1.5 1.6 1.4 1.4 1.7 1.6 1.2
1.4
1.4 1.2 1.2 1.3 1.3 1.6 1.5 1.5 1.5 ' 1.5 1.1 1.4 1.6 1.4 1.5 1.4 1.5 1.6 1.4 1.4 1.7 1.6 1.2
1.4
1.4 1.2 1.2 1.3 1.3 1.6 1.5 1.5 1.5 1.5 1.1 1.4 1.6 1.4 1.5 1.4 1.5 1.6 1.4 1.4 1.7 1.6 1.2
1.4
Gavage ml
Day 63
Gvage. ml
Day 64
1.4 1.2 1.3 1.4 1.3 1.6 1.5 1.4 1.5 1.5 1.1 1.4 1.6 1.5 1.5 1.5 1-5 1.6 1.4 1.5 1.8 ' 1.6 1.2
1.4
1.4 1.2 1.3 1.4 1.3 1.6 1.5 1.4 1.5 1.5 1.1 . 1.4 1.6 1.5 1.5 1.5 1.5 1.6 1.4 1.5 1.8 1.6 1.2
1.4
Gavage ml
Day 65
Gavage ml
Day 66
1.4 1.2 . 1.3 1.4 1.3 1.6 1.5 1.4 1.5 1.5 1.1 1.4 1.6 1.5 1.5 1.5 1.5 1.6 1.4 1.5 1.8 1.6 1.2
1.4
1.4 1.2 1.3 1.4 1.3 1:6 1.5 1.4 1.5 1.5 1.1 1.4 1.6 1.5 1.5 1.5 1.5 1.6 1.4 1.5 1.8 1.6 1.2
1.4
Company Sanitized. Does not contain TSCA CBI
-341 -
DuPont-9478
Gavage ml
Day 67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage xnl
Day 71
1.4 1.4 1.4 1.5 1.5 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.1 1.1 1.1 1.4 1.4 1.4 1.5 1.5 1.6 1.6 1.6 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.7 1.7 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4
C 90-Day Oral Gavage Study in Rats Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Gavage ml
Day 74
Female, II 0 mg/kg/day
655031
655107
6550.98 655016 655079 655036 655025 655099 655032 655083
655093 655045 655065 655074 655035 655009 655068 655019
655062 655109 655101 655072 655015 655071
655022
,
1.5 1.2 1.3 1.4 1.3 1.6. 1.6 1.5 1.5 1.5 1.1 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.8 1.7 1.2
1.4
1.5 1.2 1.3 1.4 1.3 1.6 1.6 1.5 1.5 1.5 . 1.1 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.8 1.7 1.2
1.4
1.5 1.2 1.3 1.4 1.3 1.6 1.6 1.5 1.5 1.5 1.1 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.8 1.7 1.2
1.4
Gavage ml
Day 75
Gavage ml
Day 76
1.5 1.2 1.3 1.4 1.3 1.6 1.6 1.5 1.5 1.5 1.1 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.8 1.7 1.2
1.4
1.5 1.2 1.3 1.4 1.3 1.6 1.6 1.5 1.5 1.5 1.1 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.5 1.5 1.8 1.7 1.2
1.4
Gavage ml
Day 77
1.5 1.2 1.3 1.4 1.4 1.6 1.6 1.5 1.6 1.6 1.2 1.5 1.7 1.5 1.5 1.5 1.5 1.6 1.6 1.5 1.8 1.7 1.2
1.5
Gavage ml
Day 78
1.5 1.2 1.3 1.4 1.4 1.6 1.6 1.5 1.6 1.6 1.2 1.5 1.7 1.5 1-5 1.5 1.5 1.6 1.6 1.5 1.8 1.7 1.2
1.5
Company Sanitized. Does not contain TSCA CBi
-342-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
1-5 1.5 1.5 1.5 1.5
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4
1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2
1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.8 1.8 1.8 1.8 1.8
1.7 1.7 1.7 1.7 1.7
1.2 1.2 1.2 1.2 1.2
1.5 1.5 1.5 1.5 1.5
w90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Female, II 0 mg/kg/day
655031 1.5 1.5 655107 1.3 1.3 655098 1.3 1.3 655016 1.5 1.5 655079 1.4 1.4 655036 1.7 1.7
655025 1.6 1.6
655099 1.5 1.5 655032 1.5 1.5
655083 1.6 1.6 655093 1 . 1 1 . 1
655045 1.4 1.4 655065 1.7 1.7 655074 1.5 1.5
655035 1.6 1.6
655009 1.5 1.5 655068 1.5 1.5
655019 1.6 1.6 655062 1.6 1.6
655109 1.5 1.5 655101 1.9 1.9
655072 1.6 1.6 655015 1 . 2 1 . 2
655071
655022 1.5 1.5
Gavage ml
Day 86
1.5 1.3 1.3 1.5 1.4 1.7
1.6
1.5 1.5
1.6 1.1
1.4 1.7 1.5
1.6
1.5 1.5
1.6 1.6
1.5 1.9
1.6 1.2
1.5
Gavage ml
Day 87
Gavage
ml
Day 88
-1.5 1.3
1.3 1.5 1.4 1.7
1.6
1.5
1.5
1.6 1.1
1.4 1.7 1.5
1.6
1.5 1.5
1.6 1.6
1.5 . 1.9
1.6 1.2
1.5
1.5 1.3 1.3 1.5 1.4 1.7
1.6
1.5 1.5
1.6 1.1
1.4 1.7 1.5
1.6
1.5 1.5
1.6 1.6
1.5 1.9
1.6 1.2
1.5
Gavage ml
Day 89
Gavage ml
Day 90
1.5 1.5 1.3 1.3 1.3 1.3 1.5 1.5 1.4 1.4 1.7 1.7
1.6 1.6
1.5 1.5 1.5 1.5
1.6 1.6 1.1 1.1
1.4 1.4 1.7 1.7 1.5 1.5
1.6 1.6
1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6
1.5 1.5 1.9 1.9
1.6 1.6 1.2 1.2
1.5 1.5
Company Sanitized. Does not contain TSCA CBI
-343-
Gavage ml
Day 91
Gavage ml
Day 92
Gavage ml
Day 93
1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.7 1.7 1.7
1.6 1.6 1.6
1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6 1.6 1.1
1.5
1.8
1.5
1.6 1.6
1.5
1.6 1.6
1.5
1.8 1.6
1.3
1.5
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Female, IV 1 mg/kg/day
655086 0.9 0.9 655041 0.9 0.9
655108 0.8 0.8
655040 0.9 0.9 655044 0.9 0.9
655013 1.0 1.0 655089 0.8 0.8
655091 0.9 0.9
655033 1.0 1.0 655090 1 . 1 1 . 1
655051 0.9 0.9
655018 1.0 1.0 655096 1.0 1.0 655057 0.8 0.8 655028 1.0 1.0
Gavage ml
Day 2
0.9 0.9
0.8
0.9 0.9
1.0 0.8
0.9
1.0 1.1
0.9
1.0 1.0 0.8 1.0
Gavage ml
Day 3
0.9 0.9
0.8
0.9 0.9
1.0 0.8
0.9
1.0 1.1
0.9
1.0 1.0 0.8 1.0
Gavage ml
Day 4
Gavage ml
Day 5
,Gavage
ml
Day 6
0.9 0.9 0.9
0.9 0.9 0.9
0.8 0.8 0.8
0.9 0.9 0.9
0.9 0.9 0.9
1.0 1.0 1 .0
0.8 0.8 0.8
0.9 0.9 0.9
1.0 1.0 1 .0
1.1 1.1 1.1
0.9 0.9 0.9
1 .49 1.0
1.0
1 . 1.0 1 .0
0.8 0.8 0.8 1.0 1.0 1.0
Company Sanitized. Does not contain TSCA CBI
-344-
DuPont-9478
Gavage ml
Day 7
Gavage
ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.0 1.0 1.0 1.0 1.0 1.0 1..0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.0 1.2
1.0 1.2
1.0 1.2
1.0 1.2
1.0 1.2
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1.1 1.1 1.1 1.1 1.1
1.2 1.2 1.2 1.2 1.2
1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.1 1.1 1.1
1.0 1.0 1.0 1.0 1.0
0.9
1.1
0.9
1.1
0.9
1.1
0.9
1.1
0.9
1.1
90-Day Oral Gavage StujSdyubinchRraotnsi_e__T_o_xicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12'
Gavage ml
Day 13
Gavage ml
Day 14
Female, IV 1 mg/kg/day
655086 1.0 1.0 1.0 655041 1.0 1.0 1.0 655108 1.0 1.0 1 . 1 655040 1.0 1.0 1 . 1 655044 1.0 1.0 1 . 2 655013 1 . 2 1 . 2 1.3 655089 1.0 1.0 1 . 1 655091 1.0 1.0 , 1 . 1 655033 1 . 1 1 . 1 1. 2 655090 1 . 2 1 . 2 1.3 655051 1.0 1.0 1.0 655018 1 . 1 1 . 1 1. 2 655096 1.0 1.0 1 . 1 655057 0.9 0.9 1. 0 655028 1 . 1 1 . 1 1 . 1
Gavage ml
Day 15
1.0 1.0 1.1 1.1 1.2
1.3
1.1 1.1 1.2
1.3
1.0 1.2 1.1 1.0 1.1
Gavage ml
Day 16
1.0 1.0 1.1 1.1 1.2
1.3
1.1 1.1 1.2
1.3
1.0 1.2 1.1 1.0 1.1
Gavage ml
Day 17
1.0 1.0 1.1 1.1 1.2
1.3
1.1 1.1 1.2
1.3
1.0 1.2 1.1 1.0 1.1
Gavage ml
Day 18
1.0 1.0 1.1 1.1 1.2
1.3
1.1 1.1 1.2
1.3
1.0 1.2 1.1 1.0 1.1
Company Sanitized. Does not contain TSCA CBI
-345-
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.0 1.0 1.1 1.1 1.1
1.0 1.0 1.1 1.1 1.1
1.1 1.1 1.1 1.1 1.1
1.1 1.1 1.2 1.2 1.2
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.3
1.1 1.1 1.2 1.2 1.2
1.1 1.1 1.2 1.2 1.2
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.3
1.0 1.2
1:0 1.2
1.1 1.2
1.1 1.2
1.1 1.2
1.1 1.1 1.2 1.2 1.2
1.0 1.0 1.1 1.1 1.1
1.1 1.1 1.2 1.2 1.2
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Female, IV 1 mg/kg/day
655086 1 . 1 1 . 1 655041 1 . 1 1 . 1 655108 1 . 1 1 . 1 655040 1. 2 1 . 2 655044 1. 2 1 . 2
655013 1.3 1.3
655089 1. 2 1 . 2 655091 1. 2 1 . 2 655033 1 . 2 1 . 2
655090 1.3 1.3
655051 1 . 1 1 . 1 655018 1. 2 1 . 2 655096 1. 2 1 . 2 655057 1 . 1 1 . 1 655028 1 . 2 1 . 2
Gavage ml
Day 26
1.1 1.1 1.1 1.2 1.2
1.3
1.2 1.2 1.2
1.3
.1 . 1 1.2 1.2 1.1 1.2
Gavage ml
Day 27
1.1 1.1 1.1 1.2 1.2
1.3
1.2 1.2 1.2
1.3
1.1 1.2 1.2 1.1 1.2
Gavage ml
Day 28
1.1 1.2 1.2 1.2
1.3 1.3
1.2
1.3 1.3 1.4
1.2
1.3 1.3
1.1
1.3
Gavage ml
Day 29
Gavage ml
Day 30
l.i
1.2 1.2 1.2
1.3
1.3
1.2
1.3
1.3 1.4
1.2
1.3
1.3
1.1
1.3
1.1 1.2 1.2 1.2
1.3 1.3
1.2
1.3
1.3 1.4
1.2
1.3
1.3
1.1
1.3
Company Sanitized, Does not contain TSCA CBI
-346-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage
ml Day 33
Gavage ml
Day 34
Gavage ml
Day 35
1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1 . 2 1 .2 1 .2 1 . 2 1.3 1 .2 1 .2 1. 2 1 .2 1.3
1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4
1 . 2 1 .2 1. 2 1 .2 1.3
1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.5
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3
1.1 1.1 1.1 1.1 1.2
1.3 1.3 1.3 1.3 1.3
90-Day Oral Gavage SItludSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Gavage ml
Day 38
Female, XV 1 mg/kg/day
655086 1. 2 1 . 2 1 .2
655041 1 .2 1 . 2 1. 2
655108 1.3 1.3 1.3
655040 1.3 1.3 1.3
655044 1.4 1.4 1.4
655013 1.4 1.4 1.4
655089 1.3 1.3 1.3
655091 1.4 1.4 1.4
655033
1.4
1.4
1.4
655090 1.5 1.5 1.5
655051 1 .2 1 .2 1. 2
655018 1.4 1.4 1.4
655096 1.3 1.3 1.3
655057 1. 2 1 . 2 1 . 2
655028 1.3 1.3 1.3
Gavage ml
Day 39
1.2 1.2
1.3 1.3 1.4 1.4 1.3 1.4 1.4 1.5
1.2
1.4 1.3
1.2
1.3
Gavage ml
Day 40
1.2 1.2
1.3 1.3 1-4 1.4 1.3 1.4 1.4 1.5
1.2
1.4 1.3
1.2
1.3
Gavage ml
Day 41
1.2 1.2
1.3 1.3 1.4 1.4 1.3 1.4 1.4 1.5
1.2
1.4 1.3
1.2
1.3
Gavage ml
Day 42
1.2 1 .3 1 .3 1 .4
1.5 1.4
1 .4 1 .4 1 .4 1 .5 1 .3 1 .5 1 .4 1 .3
1.3
Company Sanitized. Does not contain TSCA CBI
-347-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1,5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Gavage ml
Day 50
Female, IV 1 mg/kg/day
655086 1. 2 1 . 1 1 . 1
655041 1.3 1.3 1.3
655108 1.3 1 . 2 1. 2
655040 1.4 1.3 1.3
655044 1.5 1.4 1.4
655013 1.4 1.4 1.4
655089 1.4 1.4 1.4
655091
1.4
1.4 .
1.4
655033 1.4 1.4 1.4
655090 1.5 1.5 1.5
655051 1.3 1.3 1.3
655018 1.5 1.4 1.4
655096 1.4 1.4 1.4
655057 1.3 1 . 2 1 . 2
655028 1.3 1.4 1.4
Gavage ml
Day 51
Gavage ml
Day 52
1.1
1.3
1.2
1.3
1.4 1.4 .
1.4 ' 1.4
1.4
1.5
1.3 1.4
1.4
1.2
1.4
1.1
1.3
1.2
1.3
1.4 1.4
1.4 1.4
1.4
1.5
1.3 1.4
1.4
1.2
1.4
Gavage ml
Day 53
Gavage ml
Day 54
1.1
1.3 -
1.2
1.3
1.4
1.4
1 .4
1.4 ,
1.4
1 .5
1.3 1.4
1.4
1 .2
1.4
1 .1
1.3
1 .2 1 .3 1 .4 1 .4 1 .4 1 .4 1 .4 1 .5
1.3
1 .4 1 .4 1 .2
1.4
Company Sanitized. Does not contain TSCA CBI
-348-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
1.1 1.2 1.2 1.2 1.2
1.3
1.2
1.5 1.3
1.5 1.3
1.5 1.3
1.5 1.3
1.3 1.4 1.4 1.4 1.4
1.4 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.4 1.5 1.5 1.5 1.5
1.4 1.5 1.5 1.5 1.5
1.4 1.5 1.5 1.5 1.5
1.5 1.6 1.6 1.6 1.6
1.3 1.3 1.3 1.3 1.3
1.4 1.5 1.5 1.5 1.5
1.4 1.5 1.5 1.5 1.5
1 . 2 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4 1.4
Cl90-DJay OMral Gavage StudSyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage
ml Day 60
Gavage
ml Day 61
Gavage ml
Day 62
Gavage ml
Day 63
Female, IV 1 mg/kg/day
655086 1. 2 1. 2 1. 2 1.3
655041 1.5 1.5 1.5 1.4
655108 1.3 1.3 1.3 1.4
655040 1.4 1.4 1.4 1.4
655044 1.5 1.5 1.5 1.5
655013 1.4 1.4 1.4 1.5
655089 1.5 1.5 1.5 1.6
655091 1.5 1.5 1.5 1.5
655033
1.5
1.5 '
1.5
1.5
655090 1.6 1.6 1.6 1.6
655051 1.3 1.3 1.3 1.3
655018 1.5 1.5 1.5 1.6
655096 1.5 1.5 1.5 1.5
655057 1.3 1.3 1.3 1.3
655028 1.4 1.4 1.4 1.4
Gavage ml
Day 64
Gavage ml
Day 65
Gavage
ml
Day 66
1.3 1.3 1.3
1.4
1.4 .
1.4
1.4 1.4 1.4
1.4 1.4 1.4
1.5 1.5 1.5
1.5 1.5 1.5
1.6 1.6 1.6
1.5 1.5 1.5
1.5 1.5 1.5
1.6 1.6 1.6
1.3 1.3 1.3
1.6 1.6 1 .6
1.5 1.5 1 .5
1.3 1.3 1.3
1.4 1.4 1.4
Company Sanitized. Does not contain TSCA CBI
-349-
DuPont-9478
Gavage ml
Day 67
Gavage
ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5
1.5 1.5 1.5 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.3 1.3 1.3 1.3 1.3
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.5 1.5
90-Day Ora_l G_ a_vag,,e^.S^tSuduybicnhRroantsi_c__T_o_x_i_c_it_y
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Female, IV 1 mg/kg/day
655086 1.3 1.3 655041 1.5 1.5 655108 1.4 1.4 655040 1.5 1.5
655044 1.6 1.6
655013 1.5 1.5
655089 1.6 1.6 655091 1.6 1.6
655033 1.5 1.5
655090 1.6 1.6
655051 1.3 1.3
655018 1.6 1.6
655096 1.5 1.5 655057 1.3 1.3 655028 1.5 1.5
Gavage ml
Day 74
1.3 1.5 1.4 1.5
1.6
1.5
1.6 1.6
1.5
1.6
1.3
1.6
1.5 1.3 1.5
Gavage ml
Day 75
1.3 1.5 1.4 1.5
1.6
1.5
1.6 1.6
1.5
1.6
1.3
1.6
1.5 1.3 1.5
Gavage ml
Day 76
1.3 1.5 1.4 1.5
1.6
1.5
1.6 1.6
1.5
1.6
1.3
1.6
1.5 1.3 1.5
Gavage ml
Day 77
.Gavage ml
Day 78
1.3 1.5 .
1.4 1.5
1.6
1.5
1.6
1.5
1.5 1.7
1.4 1.7
1.5 1.4
1.5
1.3 1.5
1.4
1.5
1.6
1.5
1.6
1.5 1.5 1.7
1.4 1.7
1.5 1.4
1.5
Company Sanitized. Does not contain TSCA CBI
-350-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.4 1.4 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5
90-DAayHOHralHGaWvag^euSbtucdyhirnoRnatisc Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Gavage
ml
Day 86
Female, IV 1 mg/kg/day
655086 1.3 1.3 1.3
655041 1.5 1.5 1.5
655108 1.4 1.4 1.4
655040 1.5 1.5 1.5
655044 1.6 1.6 1.6
655013 1.5 1.5 1.5
655089 1.7 1.7 1.7
655091 1.6 1.6 1.6
655033
1.6
1.6 '
1.6
655090 1.7 1.7 1.7
655051 1.4 1.4 1.4
655018 1.7 1.7 1.7
655096 1.5 1.5 1.5
655057 1.4 1.4 1.4
655028 1.5 1.5 1.5
Gavage ml
Day 87
Gavage
ml
Day 88
1.3
1.5 1.4
1.5
1.6
1.5
1.7
1.6 1.6
1.7
1.4 1.7
1.5 1.4
1.5
1.3
1.5 1.4 1.5
1.6
1.5 1.7
1.6 1.6
1.7
1.4 1.7
1.5 1.4
1.5
Gavage ml
Day 89
Gavage ml
Day 90
1.3
1.51.4
1.5
1.6
1.5 1.7
1.6 1.6
1.7
1.4 1.7
1.5
1.4 1.5
1.3
1.5 1.4 1.5
1.6
1.5 1.7
1.6 1.6
1.7
1.4 1.7
1.5 1.4
1.5
Company Sanitized. Does not contain TSCA CBI
-351-
Gavage ml
Day 91
Gavage ml
Day 92
Gavage ml
Day 93
1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4' 1.5 1.5 1.5
1.6 1.6 1.6
1.5 1.5 1.5 1.7 1.7 1.7
1.6 1.6 1.6 1.6 1.6 1.6
1.7 1.7 1.7 1.4 1.7
1.6
1.4
1.5
DuPont-9478
90-Day Oral Gava_g_e__S_t_uduybcinhrRoantisc Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Female, VI 5 mg/kg/day
655054 655038
655034 655039 655029 655067 655020 655087 655066 655042
655059 655064 655050 655021
655017
0.8
0.9
0.9 0.9
0.9
1.0
0.7
0.9
1.0 1.1 0 .8. 1.0 1.0 0.8
0.9
0.8
0.9
0.9
0.9
0.9
1.0
0.7
0.9
1.0 1.1 0.8 1.0 1.0 0.8
0.9
Gavage ml
Day 2
Gavage ml
Day 3
0.8 .
0.9
0.9
0.9
0.9
1.0
0.7
0.9
1.0 1.1 0.8 1.0 1.0 0.8
0.9
0.8
0.9
0.9
0.9
0.9
1.0
0.7
0.9
1.0 1.1 0.8 1.0 1.0 0.8
0.9
Gavage ml
Day 4
0.8
0.9 0.9 0.9 0.9
1.0
0.7 0.9
1.0 1.1 0.8 1.0 1.0 0.8
0.9
Gavage ml
Day 5
.Gavage ml
Day 6
0.8
0.9 .
0.9
0.9
0.9
1.0
0.7
0.9
1.0 1.1 0.8 1.0 1.0 0.8
0.9
0 .8
0.9
0.9 0.9
0.9 1.0
0.7
0.9
1 .0 1.1 0.8 1.0 1 .0 0.8
0.9
Company Sanitized. Does not contain TSCA CBI
- 352
DuPont-9478
Gavage ml
Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
1.1 1.0
1.1 1.0
1.1 1.0
1.1 1.0
1.1 1.0
1.1 1.1 1.2
1.1 1.1 1.2
1.1 1.1 1.2
1.1 1.1 1.2
1.1 1.1 1.2
0.9
1.0
0.9
1.0
0.9
1.0
0.9
1.0
0.9
1.0
1.0 1.0 1.0 1.0 1.0
0.9 0.9 0.9 0.9 0.9
1.0 1.0 1.0 1.0 1.0
_9_0_-_D__a_y_O__ra_l_GSauvbacghrennSitfu*d. TyoinxiRciatyts_________
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Female, VI 5 mg/kg/day
655054 1.0 1.0
655038 1.0 1.0
655034 1.0 1.0
655039 1.0 1.0
655029 1.0 1.0
655067
1.1
1.1
655020 1.0 1.0
655087 1 . 1 1 . 1
655066 1 . 1 1 . 1
655042 1.2 1.2
655059 0.9 0.9
655064 1.0 1.0
655050 1.0 1.0
655021 0.9 0.9
655017 1.0 1-0
Gavage ml
Day 14
1.0 1.1 1.1 1.1 1.1 1.2 1.1 1.2 1.2
1.3
1.0 1.1 1.2 1.0 1.1
Gavage ml
Day 15
1.0 1.1 1.1 1.1 1.1 1.2 1.1 1.2 1.2
1.3
1.0 1.1 1.2 1.0 1.1
Gavage
ml Day 15
Gavage
ml Day 17
Gavage
ml Day 18
1.0 1 .0 1 .0 1.1 1.1 . 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1 . 1 1 .1 1 .1 1 .2 1 .2 1 .2 1.1 1.1 1-1 1.2 1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3
1.0 1.0 1.0 1.1 1.1 1.1 1.2 1.2 1.2 1.0 1.0 1.0 1.1 1.1 1.1
Company Sanitized. Does not contain TSCA CBi
-353 -
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage
ml Day 22
Gavage ml
Day 23
1.0 1.0 1.1 1.1 1.1
1.1 1. 1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4
1.0 1.0 1.0 1.0 1.0
1.1 1.1 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2
1.0 1.0 1.1 1.1 1.1
1.1 1.1 1.1 1.1 1.1
L 90-jDBaMy OMraMl GBavMagBe^SStuudbycinh rRoantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Gavage ml
Day 26
Female, VI 5 mg/kg/day
655054 1 . 1 1 . 1 1 . 1
655038
1.2
1.2
1.2
655034 1 . 1 1 . 1 1 . 1
655039 1. 2 1 . 2 1 . 2
655029 1. 2 1 . 2 1 . 2
655067 1.3 1.3 1.3
655020 1 . 1 1 . 1 1 . 1
655087 1.3 1.3 1.3
655066
1.3
1.3 '
1.3
655042 1.4 1.4 1.4
655059 1.0 1.0 1.0
655064 1.3 1.3 1.3
655050 1. 2 1 . 2 1 .2
655021 1 . 1 1 . 1 1 . 1
655017 1 . 1 1 . 1 1 . 1
Gavage ml
Day 27
1.1 1.2 1 . 1 1.2 1.2
1.3
1.1
1.3 1.3 1.4
1.0
1.3
1.2 1.1 1.1
Gavage ml
Day 28
1.2 1.2 1.2 1.2
1.3 1.4
1.2
1.3 1.4 1.4
1.1
1.3 1.3
1.2 1.2
Gavage ml
Day 29
1.2 1.2 1.2 1.2
1.3 1.4
1.2
1.3 1.4 1.4
1.1
1.3 1.3
1.2 1.2
Gavage ml
Day 30
1.2 1.2 1.2 1.2
1.3 1.4
1.2
1.3 1.4 1.4
1.1
1.3 1.3
1.2 1.2
Company Sanitized. Does not contain TSCA CBI
-354-
)
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml.
Day 34
Gavage ml
Day 35
1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4
1 . 2 1.2 1.2 1.2 1.3
1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.6
1.1 1.1 1.1 1.1 1 . 1
1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2
^ 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Gavage ml
Day 38
Female, VI 5 mg/kg/day
655054 1. 2 1 . 2 1 .2
655038 1.3 1.3 1.3
655034 1. 2 1. 2 1 .2
655039 1.3 1.3 1.3
655029 1.3 1.3 1.3
655067 1.4 1.4 1.4
655020 1.3 1.3 1.3
655087 1.4 1.4 1.4
655066
1.4
1.4 '
1.4
655042 1.6 1.6 1.6
655059 1 . 1 1 . 1 1 . 1
655064 1.4 1.4 1.4
655050 1.3 1.3 1.3
655021 1 .2 1 .2 1 .2
655017 1. 2 1 .2 1 .2
Gavage ml
Day 39
1.2
1.3
1.2
1.3 1.3 1.4 1.3 1.4 1.4
1.6 1.1
1.4 1.3
1.2 1.2
Gavage ml
Day 40
1.2
1.3
1.2
1.3 1.3 1.4 1.3 1.4 1.4
1.6 1.1
1.4 1.3
1.2 1.2
Gavage ml
Day 41
1.2
1.3
1.2
1.3 1.3 1.4 1.3 1.4 1.4
1.6 1.1
1.4 1.3
1.2 1.2
Gavage ml
Day 42
1.2
1.4 1.3 1.4 1.3 1.4 1.4 1.5 1.5
1.6 1.2
1.5 1.4
1.2
1.3
Company Sanitized. Does not contain TSCA
oCD
DuPont-9478
Gavage ml
Day 43
Gavage
ml Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage
ml Day 47
1.2 1.2 1.2 1.2 1.2
1.4 1.4 1.4 1.4 1.4
1.3 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4 1.4
1.3 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.4 1.4
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.2 1.2 1.2 1.2 1.2
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.2 1.2 1.2 1.2 1.2
1.3
1.3
1.3
1.3 '
1.3
90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49%
Female, VI 5 mg/kg/day
655054 1 . 2 1 . 2
655038 1.4 1.3
655034 1.3 1 . 2
655039 1.4 1.4 655029 1.3 1.3 655067 1.4 1.4 655020 1.4 1.4 655087 1.5 1.4 655066 1.5 1.4
655042 1.6 1.5 655059 1.2 1 . 2 655064 1.5 1.6
655050 1.4 1.4
655021 1 . 2 1.3
655017 1.3 1.3
Gavage ml
Day 50
1.2
1.3
1.2
1.4 1.3 1.4 1.4 1-4 1.4 1.5
1.2 1.6
1.4 1.3 1.3
Gavage ml
Day 51
1.2
1.3
1.2
1.4 1.3 1.4 1.4 1.4 1.4 1.5
1.2 1.6
1.4 1.3 1.3
Gavage ml
Day 52
1.2
1.3
1.2
1.4 1.3 1.4 1.4 1.4 1.4 1.5
1.2 1.6
1.4 1.3 1.3
Gavage ml
Day 53
Gavage ml
Day 54
1.2
1.3 .
1.2
1.4
1.3 1.4
1.4
1.4 1.4
1.5
1.2 1.6
1.4
1.3
1.3
1.2
1.3
1.2
1.4
1.3 1.4
1.4
1.4 1.4
1.5
1.2 1.6
1.4
1.3
1.3
Company Sanitized. Does not contain TSCA
CoD
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
1 . 2 1.3 1.3 1.3 1.3
1.3 1.4 1.4 1.4 1.4
1 . 2 1.3 1.3 1.3 1.3
1.4 1.5 1.5 1.5 1.5
1.3 1.4 1.4 1.4 1.4
1.4 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.4 1.5 1 ;5 1.5 1.5
1.4
1.5
1.5
1.5 .
1.5
1.5 1.7 1.7 1.7 1.7
1.2 1.2 1.2 1.2 1.2
1.6 1.6 1.6 1.6 1.6
1.4 1.4 1.4 1.4 1.4
11.. 33
11.. 33
11.. 33
1.3 1.3
1.3 1.3
J-Day_U__ra_l_G_ avage jSQtusduybicnhRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml.
Day 61
Female, VI 5 mg/kg/day
655054 1.3 1.3 655038 1.4 1.4 655034 1.3 1.3 655039 1.5 1.5 655029 1.4 1.4 655067 1.5 1.5 655020 1.4 1.4 655087 1.5 1.5 655066 1.5 1.5 655042 1.7 1.7
655059 1 . 2 1 . 2 655064 1.6 1.6
655050 1.4 1.4 655021 1.3 1.3 655017 1.3 1-3
Gavage ml
Day 62
1.3 1.4 1.3 1.5 1.4 1.5 1.4 1.5 1..5 1.7
1.2 1.6
1.4 1.3 1.3
Gavage ml
Day 63
1.3 1.5 1.3 1.5 1.4 1.5 1.5
1.6 1.6
1.7 1.3
1.6
1.5 1.3 1.3
Gavage ml
Day 64
Gavage ml
Day 65
Gavage ml
Day 66
1.3 1.3 1.3
1.5
1.5
1.5
1.3 1.3 1.3
1.5. 1.5 1 .5
1.4 1.4 1.4
1.5 1.5 1.5
1.5 1.5 1.5
1.6 1.6 1.6
1.6 1.6 1.6
1.7 1.7 1.7
1.3 1.3 1.3
1.6 1 .6 1 .6
1.5 1.5 1.5
1.3 1.3 1.3
1.3 1.3 1.3
Company Sanitized. Does not contain TSCA CBI
-357-
DuPont-9478
Gavage ml
Day 67
Gavage
ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
1.3 1.3 1.3 1.3 1.3
1.5 1.5 1.5 1.5 1.5
1.3 1.3 1.3 1.4 1.4
1.5 1.5 1.5 1.6 1.6
1.4 1.4 1.4 1.4 1.4
1.5 1.5 1.5 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.6 1.6 1.6 1.5 1.5
1.7 1.7 1.7 1.7 1.7
1.3
1.6
1.3
1.6
1.3
1.6
1.3
1.6 '
1.3
1.6
1.5 1.5 1.5 1.5 1.5
11.. 33
1.3 1.3
1.3 1.3
1.4 1.4
1.4 1.4
( S>uj-HDaHy OIr^aHl GHav^aIgQe SStuudbycihnrRoantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Gavage ml
Day 74
Female, VI 5 mg/kg/day
655054 1.3 1.3 1.3
655038 1.5 1.5 1.5
655034 1.4 1.4 1.4
655039 1.6 1.6 1.6
655029 1.4 1.4 1.4
655067 1.6 1.6 1.6
655020 1.5 1.5 1.5
655087 1.6 1.6 1.6
655066
1.5
1.5 '
1.5
655042 1.7 1.7 1.7
655059 1.3 1.3 1.3
655064 1.6 1.6 1.6
655050 1.5 1.5 1.5
655021 1.4 1.4 1.4
655017 1.4 1.4 1.4
Gavage ml
Day 75
1.3 1.5 1.4 1.6 1.4 1.6 1.5 1.6 1.5 1.7 1.3 1.6 1.5 1.4 1.4
Gavage ml
Day 76
1.3 1.5 1.4 1.6 1.4 1.6 1.5 1.6 1.5 1.7 1.3 1.6 1.5 1.4 1.4
Gavage ml
Day 77
1.3 1.5 1.4 1.6 1.5 1.6 1.5 1.6 1.6 1.8 1.3 1.7 1.5 1.4 1.4
Gavage ml
Day 78
1.3 1.5 1.4 1.6 1.5 1.6 1.5 1.6 1.6 1.8 1.3 1.7 1.5 1.4 1.4
Company Sanitized. Does not contain TSCA C81
- 358-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.8 1.8 1.8 1.8 1.8 1.3 1.3 1.3 1.3 1.3 1.7 1.7 1.7 1.7 1.7 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4
CL90-Day Oral Gavage Study in Rats Toxicity
)
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Female, VI 5 mg/kg/day
655054 1.4 1.4
655038 1.5 1.5
655034
1.4. 1.4
655039 1.6 1.6
655029 1.4 1.4
655067 1.6 1.6
655020 1.5 1.5
655087 1.6 1.6
655066 1.6 1.6
655042 1.8 1.8
655059 1.3 1.3
655064 1.7 1.7
655050 1.5 1.5
655021 1.4 1.4
655017 1.4 1.4
Gavage ml
Day 86
1.4 1.5 1.4
1.6
1.4
1.6
1.5
1.6 1.6 1.8
1.3 1.7 1.5 1.4 1.4
Gavage ml
Day 87
1.4 1.5 1.4
1.6
1.4
1.6
1.5
1.6 1.6 1.8
1.3 1.7 1.5 1.4 1.4
Gavage ml
Day 88
1.4 1.5 1.4
1.6
1.4
1.6
1.5
1.6 1.6 1.8
1.3 1.7 1.5 1.4 1.4
Gavage ml
Day 89
Gavage ml
Day 90
1.4 1.5 . 1.4
1.6
1.4
1.6
1.5
1 .6' 1.6 1.8
1.3 1.7 1.5
1.4
1.4
1.4
1.5
1.4
1.6
1.4
1.6
1.5
1.6 1.6 1.8
1.3 1.7
1.5
1.4
1.4
Company Sanitized. Does not contain TSCA
CoO
Gavage ml
Day 91
Gavage ml
Day 92
Gavage ml
Day 93
1.3 1.3 1.3 1.5 1.5 1.5 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.8 1.8 1.8
1.3 1.7
1.5 1.4
1.4
DuPont-9478
90-_D_a_y Oral Gavage StuIdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Female, VIII 25 mg/kg/day
655058 0.9 0.9 655076 0.9 0.9
655047 0.8 0.8
655055 0.9 0.9 655105 0.9 0.9
655078 1.0 1. 0
655073 0.9 0.9 655011 0.9 0.9
655085 1.0 1.0 655012 1.0 1.0
655043 0.9 0.9
655082 1.0 1.0
655060 0.9 0.9
655056 0.8 0.8
655081 0.9 0.9
Gavage ml
Day 2
0.9 0.9
0.8
0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9
0.8
0.9
Gavage ml
Day 3
0.9 0.9
0.8
0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9
0.8
0.9
Gavage ml
Day 4
0.9 0.9
0.8
0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9
0.8
0.9
Gavage ml
Day 5
0.9 0.9
0.8
0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9
0.8
0.9
Gavage ml
Day 6
0.9 0,9
0.8
0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9
0.8
0.9
Company Sanitized. Does not contain TSCA CBI
-360-
DuPont-9478
Gavage ml
Day 7
Gavage
ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.0 1.0 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0
0.9
1.0
0.9
1.0
0.9
1.0
0.9
1.0
0.9
1.0
1.0 1.0 1.0 1.0 1.0
1 .2 1 .2 1 . 2 1.2 1 .2
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1 . 1 1 . 1 1.1 1.1 1 . 1
1.1 1 . 1 1 . 1 1 . 1 1 . 1
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1.0 1.0
1.0
10..18
1.0
10..18
1.0
10..18
1.0
10..18
1.0
10..18
'ay Oral Gavage StuJdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Gavage ml
Day 14
Female, VIII 25 mg/kg/day
655058 1.0 1.0 1 . 1
655076 1.0 1.0 1 . 1
655047 0.9 0.9 1. 0
655055 1.0 1.0 1 . 1
655105
1.0
1 .0"
1.1
655078 1 . 2 1 . 2 1.3
655073 1.0 1.0 1 . 1
655011 1.0 1.0 1 . 1
655085 1 . 1 1 . 1 1 . 2
655012
1.1
1.1
1.2
655043 1.0 1.0 1 . 1
655082 1.0 1.0 1. 2
655060 1.0 1.0 1 . 1
655056 0.8 0.8 1.0
655081 1 . 1 1 . 1 1 . 1
Gavage ml
Day 15
1.1 1.1 1.0 1.1 1.1
1.3
1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.0 1.1
Gavage ml
Day, 16
1.1 1.1 1.0 1.1 1.1
1.3
1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.0 1.1
Gavage ml
Day 17
Gavage ml
Day 18
1.1 1.1 . 1.0 1.1 1.1
1.3
1.1 1.1 1.2 ' 1.2 1.1 1.2 1.1 1.0 1.1
1.1 1.1 1.0 1.1 1.1
1.3
1.1 1.1 1.2 1.2 1.1 1.2 1.1 1.0 1.1
Company Sanitized. Does not contain TSCA CBI
-361 -
DuPont-9478
Gavage ml
Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.1 1.1 1.2 1.2 1.2
1.1 1.1 1.2 1.2 1.2
1.0 1.0 1.1 1.1 1.1
1.1 1.1 1.2 1.2 1.2
1.1 1.1 1.1 1.1 1.1
1.3 1.3 1.3 1.3 1.3
1.1 1.1 1.2 1.2 1.2
1.1 1.1 1.2 1.2 1.2
1.2 1.2
1.2 1.2
1.3 1.3
1.3 1.3
1.3 1.3
1.1 1.2
1.1 1.2
1.1 1.2
1.1 1.1 1.2 1.2
1.1 1.1 1.2 1.2 1.2
1.0 1.0 1.0 1.0 1.0
1 . 1 1 . 1 1.3 1.3 1.3
l90-Day Oral Gavage Stu_dSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Female, VIII 25 mg/kg/day
655058 1 . 2 1 . 2 655076 1 . 2 1 . 2 655047 1 . 1 1 . 1 655055 1 . 2 1 . 2 655105 1 . 1 1 . 1
655078 1.3 1.3
655073 1 . 2 1. 2 655011 1 . 2 1 . 2
655085 1.3 1.3 655012 1.3 1.3
655043 1 . 1 1 . 1 655082 1 . 2 1 . 2 655060 1 . 2 1 . 2 655056 1.0 1 .0
655081 1.3 1.3
Gavage ml
Day 26
1.2 1.2 1.1 1.2 1.1
1.3
1.2 1.2
1.3 1.3
1.1 1.2 1.2 1.0
1.3
Gavage ml
Day 27
1.2 1.2 1.1 1.2 1.1
1.3
1.2 1.2
1.3 1.3
1.1 1.2 1.2 1.0
1.3
Gavage ml
Day 28
1.2 1.2 1,1 1.2 1.1
1.4 1.3 1.3 1.4 1.3
1.2
1.3 1.3
1.1
1.3
Gavage ml
Day 29
1.2 1.2 1.1 1.2 1.1
1.4
1 .3
1.3 1.4 1.3
1.2
1.3 1.3
1.1
1.3
Gavage ml
Day 30
1.2 1.2 1.1 1.2 1.1
1.4
1 .3
1.3 1.4 1.3
1.2
1.3 1.3
1 .1
1.3
Company Sanitized. Does not contain TSCA
o OJ
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
1.2 1.2
1.2 1.2
1.2 1.2
1.2 1.2
1.3 1.3
1.1 1.2
1.1 1.2
1.1 1.2
1.1 1.2
1.2
1.3
1 . 1 1 . 1 1 . 1 'l.l 1 .2
1.4 1.4. 1.4 1.4 1.5
1.3 1.3 1.3 1.3 1.3
1.3 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4 1.5
1.3 1.3 1.3 1.3 1.4
1.2 1.2 1.2 1.2 1.2
1.3 1.3 1.3 1.3 1.4
1.3 1.3 1.3 1.3 1.3
1.1 1.1 1.1 1.1 1.2
1.3 1.3 1.3 1.3 1.4
)ay Oral Gavage StuFdSyuibnchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Gavage ml
Day 38
Female, Viri 25 mg/kg/day
655058 1.3 1.3 1.3
655076 1.3 1.3 1.3
655047 1. 2 1 .2 1 . 2
655055 1.3 1.3 1.3
655105 1 .2 1 .2 1. 2
655078 1.5 1.5 1.5
655073
1.3
1.3
1.3
655011 1.3 1.3 1.3
655085 1.5 1.5 1.5
655012 1.4 1.4 1.4
655043 1 . 2 1 . 2 1 .2
655082 1.4 1.4 1.4
655060 1.3 1.3 1.3
655056 1. 2 1 . 2 1 .2
655081 1.4 1.4 1.4
Gavage ml
Day 39
1.3 1.3
1.2
1.3
1.2
1.5 1.3 l.s3 1.5 1.4
1.2
1.4 1.3
1.2
1.4
Gavage ml
Day 40
1.3 1.3
1.2
1.3
1.2
1.5 1.3 1.3 1.5 1.4
1.2
1.4 1.3
1.2
1.4
Gavage ml
Day 41
1.3
1 .3 1.2
1.3
1.2
1.5 1.3 1.3
1 .5
1.4
1.2
1.4 1.3
1.2
1.4
Gavage ml
Day 42
1 .4 1 .4 1 .3 1 .4 1 .3 1 .6 1 .4 1 .4 1 .5
1.4
1 .3 1 .5 1 .4 1 .2
1.4
Company Sanitized. Does not contain TSCA CBI
-363 -
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage nil
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.3 1 ;3 1.3 1.3 1.3
1.6 1.6 1.6 1.6 1.6
1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4
1.2 1.2 1.2 1.2 1.2
1.4 1.4 1.4 1.4 1.4
a 90-D-afylHOrHalHGMavaNgeySStuiidbycihnrRoantsic _T_o_x_i_ci_t_y
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Female, VIII 25 mg/kg/day
655058 1.4 1.3 655076 1.4 1.3
655047 1.3 1 . 2
655055 1.4 1.3
655105 1.3 1 . 2 655078 1.6 1.6
655073 1.4 1.3 655011 1.4 1.3 655085 1.5 1.5 655012 1.4 1.4
655043 1.3 1 . 2
655082 1.5 1.5 655060 1.4 1.5
655056 1. 2 1 . 2
655081 1.4 1.5
Gavage ml
Day 50
1.3 1.3
1.2
1.3
1.2 1.6
1.3 1.3 1.5 1.4
1.2
1.5 1.5
1.2
1.5
Gavage ml
Day 51
1.3 1.3
1.2
1.3
1.2 1.6
1.3 1.3 1.5 1.4
1.2
1.5 1.5
1.2
1.5
Gavage ml
Day 52
1.3 1.3
1.2
1.3
1.2 1.6
1.3 1.3 1.5 1.4
1.2
1.5 1.5
1.2
1.5
Gavage ml
Day 53
1.3 1.3
1.2
1.3
1.2 1-6
1.3 1.3 1.5 1.4
1.2
1.5 1.5
1.2
1.5
Gavage ml
Day 54
1.3 1.3
1.2
1.3
1.2 1.6
1.3 1.3 1.5 1.4
1.2
1.5 1.5
1.2
1.5
Company Sanitized. Does not contain TSCA CBI
-364-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
1.3 1.4 1.4 1.4 1.4
1.3 1.4 1.4 1.4 1.4
1 . 2 1.3 1.3 1.3 1.3
1.3
1.4
1.4
1.4
1.4
1 . 2 1.4 1.4 1.4 1.4
1.5 1.8 1.8 1.8 1.8
1.3 1.4 1.4 1.4 1.4
1.3 1.5 1.5 1.5 1.5
1:5 1.6 1.6 1.6 1.6
1.4 1.5 1.5 1.5 1.5
1 . 2 1.3 1.3 1.3 1.3
1.5 1.5 1.5 1.5 1.5
1.5 1.6 1.6 1.6 1.6
1 . 2 1.3 1.3 1.3 1.3
1.5 1.6 1.6 1. 6 1. 6
c*90-Day Oral G__a_v_a_g_e _StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
VIII 25 mg/kg/day
655058 655076
655047 655055 655105 655078 655073 655011
655085 655012 655043 655082 655060 655056 655081
1.4
1.4
1.3 1.4
1.4
1.8
1.4 1.5
1.6
1.5
1.3 1.5
1.6
1.3
1.6
.
1.4
1.4
1.3 1.4
1.4
1.8
1.4 1.5
1.6
1.5
1.3 1.5
1.6
1.3
1.6
Gavage ml
Day 62
1.4 1.4 1.3 1.4 1.4
1.8
1.4 1.5
1.6
1.5 1.3 1.5
1.6
1.3
1.6
Gavage ml
Day 63
1.4 1.4 1.3 1.4 1.4 1.7 1.5 1.5
1.6
1.5 1.3
1.6 1.6
1.3
1.6
Gavage ml
Day 64
1.4 1.4 1.3 1.4 1.4 1.7 1.5 1.5
1.6
1.5 1.3
1.6 1.6
1.3
1.6
Gavage ml
Day 6.5
Gavage
ml
Day 66
1.4 1 .4
1.4 1.4
1.3 1 .3
1.4 1.4 1.4 1.4 1.7 1.7
1.5 1-5 1.5 1.5
1.6 1.6
1.5 1.5
1.3 1.3
1.6 1 .6 1.6 1.6
1.3 1.3
1.6 1.6
Company Sanitized. Does not contain TSCA CBI
-365-
DuPont-9478
Gavage ml
Day 67
Gavage
ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
1.4 1.4 1.4 1.4 1.4
1.4 1.4 1.4 1.5 1.5
1.3 1.3 1.3 1.4 1.4
1.4 1.4 1.4 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.7 1.7 1.7 1.8 1.8
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.7 1.7
1.5 1.5 1.5 1.6 1.6
1.3
1.6
1.3 1.6
1.3 1.6
1.3 1.3
1 .6 1.6
1.6 1.6 1.6 1.6 1.6
1.3 1.3 1.3 1.4 1.4
1.6 1.6 1.6 1.6 1.6
90-Day Oral Gavag_e__StuIdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Female, VIII 25 mg/kg/day
655058 1.4 1.4 655076 1.5 1.5 655047 1.4 1.4 655055 1.5 1.5 655105 1.4 1.4
655078 1.8 1. 8
655073 1.5 1.5 655011 1.5 1-5 655085 1.7 1.7
655012 1.6 1.6
655043 1.3 1.3
655082 1.6 1.6 655060 1.6 1.6
655056 1.4 1.4
655081 1.6 1.6
Gavage ml
Day 74
1.4 1.5 1.4 1.5 1.4
1.8
1.5 1.5 1.7
1.6
1.3
1.6 1.6
1.4
1.6
Gavage ml
Day 75
1.4 1.5 1.4 1.5 1.4
1.8
1.5 1.5 1.7
1.6
1.3
1.6 1.6
1.4
1.6
Gavage ml
Day 76
Gavage ml
Day 77
Gavage ml
Day 78
1.4
1-5 .
1.4 1.5
1.4
1.8
1.5 1.5 1.7
1.6
1.3
1.6 1.6
1.4
1.6
1.5 1.5
1.4 1.5
1.4
1.9
1.6 1.6 .
1.7
1.6
1.4
1.6
1.7 ,
1.4 1.7
1.5 1.5
1.4 1.5
1.4 1.9
1.6 1.6
1.7
1.6
1.4
1 .6
1.7
1.4 1.7
Company Sanitized. Does not contain TSCA CB
-366-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
Day 82
Gavage ml
Day 83
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.9 1.9 1.9 1.9 1.9
1.6 1-6 1.6 1.6 1.6
1.6 1-6 1.6 1.6 1.6
1.7 1.7 1.7 1.7 1.7
1.6 1.6 1.6 1.6 1.6
1.4 1.4 1.4 1.4 1.4
1.6 1.6 1.6 1.6 1.6
1.7 1.7 1.7 1.7 1.7
1.4 1.7
1.4 1.7
1.4 3.7
h1..47
11.. 74
c90-Day Oral Gavage__S_t_uSdyubicnhRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Female, VIII 25 mg/kg/day
655058 655076
655047 655055
655105 655078 655073 655011
655085 655012
655043 655082
655060 655056 655081
1.5 1.5
1.4 1.4
1.4
1.8 1.6 1.6
1.7
1.6
1.4
1.6
1.7
1.4 . 1.7
1.5
1.5
1.4 1.4
1.4
1 . 8 1.6 1.6
1.7
1.6
1.4
1.6
1.7
1.4
1.7
Gavage ml
Day 86
1.5 1.5 1.4 1.4 1.4
1.8 1.6 1.6
1.7
1.6
1.4
1.6
1.7 1.4 1.7
Gavage ml
Day 87
1.5 1.5 1.4 1.4 1.4
1.8 1.6 1.6
1.7
1.6
1.4
1.6
1.7 1.4 1.7
Gavage ml
Day 88
1.5 1.5 1.4 1.4 1.4
1.8 1.6 1.6
1.7
1.6
1.4
1.6
1.7 1.4 1.7
Gavage ml
Day 89
Gavage ml
Day- 90
1.5
1.5
1.4 '
1.4
1.4
1.8 1.6 1.6
1.7
1.6
1.4
1.6
1.7
1.4 1.7
1.5
1.5 1.4
1.4 1-4
1.8 .1 . 6 1.6
1.7
1.6
1.4
1 .6
1.7 1.4 1.7
Company Sanitized. Does not contain TSCA CBI
-367-
Gavage ml
Day 91
Gavage ml
Day 92
Gavage ml
Day 93
1.5 1.5 1.5 1.5 1.3 1.3 1.5 1.5
1-4 1.4 1.8 1.8 1.6 ' 1.6 1-6 1.6 1-7 1.7
1.6 1.6 1.4 1.6 1.7 1.4 1.7
1.5 1.5 1.3 1.5
1.4 1.8 1.6 1.6 1.7
1.6
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 0
Gavage ml
Day 1
Female, X 125 mg/kg/day
655097 0.9 0.9
655052 1.0 1.0 655063 0.8 0.8
655103 0.9 0.9 655026 0.9 0.9
655095 1.0 1.0
655023 0.9 0.9 655007 0.9 0.9
655053 1.0 1.0 655092 1.0 1.0
655046 0.9 0.9
655027 1.0 1.0
655104 0.9 0.9
655106 0.8 0.8 655024 1.0 1.0
655037 0.9 0.9
655088 1.0 1.0 655010 1.0 1.0 655077 1.0 1.0 655030 1.0 1.0 655075 1.0 1.0 655100 1 . 1 1 . 1 655049 0.8 0.8 655084 0.8 0.8 655061 0.8 0.8
Gavage ml
Day 2
Gavage ml
Day 3
0.9
1.0 0.8
0.9
0.9
1.0
0.9
0.9
1.0 1.0
0.9
1.0
0.9
0.8 1.0
0.9
1.0 1.0 1.0 1.0 1.0 ! 1.1 0.8 0.8 0.8
0.9
1.0 0.8
0.9
0.9
1.0
0.9
0.9
1.0 1.0
0.9
1.0
0.9
0.8 1.0
0.9
1.0 1.0 1.0 1.0 1.0 1.1 0.8 0.8 0.8
Gavage ml
Day 4
Gavage ml
.Day 5
0.9 0.9
1.0 1.0
0.8 0.8 0.9 0.9
0.9 0.9
1.0 1.0
0.9 0.9
0.9 0.9
1.0 1.0 1.0 1.0
0.9 0.9
1..0 1.0
0.9 0.9
0.8 0.8 1.0 1.0
0.9 0.9
1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
1.1 1.1
0.8 0.8 0.8 0.8 0.8 0.8
Gavage ml
Day 6
0.9
1.0
0.8 0.9 0.9
1.0
0.9 0.9
1.0 1.0
0.9
1.0
0.9 0.8
1.0
0.9
1.0 1.0 1.0 1.0 1.0
1.1 0.8 0.8 0.8
Company Sanitized. Does not contain TSCA CBi
-368-
DuPont-9478
ige ml Day 7
Gavage ml
Day 8
Gavage ml
Day 9
Gavage ml
Day 10
Gavage ml
Day 11
1.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 1.1 0.9 0.9 0.9 0.9 0.9 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 1.1 1.1. 1.1 1.1 1.1 1.0 1.0 1.0 1.0 1.0 0.8 0.8 0.8 0.8 0.8 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 0.9 0.9 0.9 0.9 0.9 1.0 1.0 1.0 1.0 1.0 0.9 0.9 0.9 0.9 0.9
90-Day Oral GavagBeUStuJdSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 12
Gavage ml
Day 13
Gavage ml
Day 14
Female, X 125 mg/kg/day
655097 1.0 1.0 1.1
655052 1.1 1.1 1.1
655063 0.9 0.9 1.0
655103 1.1 1.1 1.2
655026 1.1 1.1 1.2
655095 1.1 1.1 1.3
655023 1.0 1.0 1.1
655007 1.0 1.0 , 1.1
655053 1.1 1.1 1.2
655092 1.1 1.1 1.2
655046 1.0 1.0 1.1
655027 1.1 1.1 1.2
655104 1.0 1.0 1.1
655106 0.8 0.8 0.9
655024 1.1 1.1 1.2
655037 1.1 1.1 1.2
655088 1.1 ,1.1 1.2
655010 1.1 1.1 1.2
655077 1.1 1.1 1.1
655030 1.1 1.1 1.3
655075 1.1 1.1 1.2
655100 1.2 1.2 1.3
655049
0.9
0.9
1.0
655084 1.0 1.0 1.1
655061 0.9 0.9 1.0
Gavage ml
Day 15
1.1 1.1 1.0 1.2 1.2 1.3 1.1 1.1 1.2 1.2 1.1 1.2 1.1 0.9 1.2 1.2 1.2 1.2 1.1 1.3 1.2 1.3 1.0 1.1 1.0
Gavage ml
Day 16
1.1 1.1 1.0 1.2 1.2 1.3 1.1 1.1 1.2 1.2 1.1 1.2 1.1 0.9 1.2 1.2 1.2 1.2 1.1 1.3 1.2 1.3 1.0 1.1 1.0
Gavage ml
Day 17
Gavage
ml Day 18
1.1 1.1 1.0 1.2
1.2 1.3
1.1 1.1 1.2 1.2
1.1 1.2 1.1 0.9 1.2 1.2 1.2
1.2. 1.1 1.3 1.2 1.3
1.0
1.1 1.0
1.1
1.1 1.0 1.2 1.2 1.3 1.1 1.1
1.2 1.2 1.1 1.2 1.1 0.9 1.2 1.2 1.2 1.2 1.1
1.3 1.2
1.3 1.0
1.1
1.0
Company Sanitized. Does not contain TSCA CBI
-369-
DuPont-9478
Gavage
ml Day 19
Gavage ml
Day 20
Gavage ml
Day 21
Gavage ml
Day 22
Gavage ml
Day 23
1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.2 1.2 1.2 1.0 1.0 1.1 1.1 1.1 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.1 1.1 1.2 1.2 1.2 1.1 1.1 1.1 1.1 1.1. 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.2 1.2 1.2 0.9 0.9 1.0 1.0 1.0 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.3 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.2 1.2 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.0 1.0 1.1 1.1 1.1
1.1 1.1 1.2 1.2 1.2 1.0 1.0 1.2 1.2 1.2
90-Day Oral Gavage StJuSduybinchRroatnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 24
Gavage ml
Day 25
Female, X 125 mg/kg/day
655097
655052 655063 655103 655026
655095 655023 655007
655053 655092
655046 655027 655104 655106 655024
655037
655088 655010 655077
655030 655075 655100 655049 655084 655061
1.2 1.2 1.2 1.2 1.1 1.1 1.3 1.3 1.3 1.3 1.4 1.4 1.2 1.2 1.1 1.1 1.3 ' 1.3 1.3 1.3 1.2 1.2 1.3 1.3 1.2 1.2
1.0 1.0 1.3 ' 1.3
1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3
1.4 1.4 1.4 1.4
1.4 1.4
1.1 1.1 1.2 1.2 1.2 1.2
Gavage ml
Day 26
1.2 1.2 1.1 1.3 1.3 1.4 1.2 1.1 1.3 1.3 1.2 1.3 1.2 1.0 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.1 1.2 1.2
Gavage ml
Day 27
1.2 1.2 1.1 1.3 1.3 1.4 1.2 1.1 1.3 1.3 1.2 1.3 . 1.2 1.0 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.1 1.2 1.2
Gavage ml
Day 28
1.2 1.2 1.1 1.4 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.4 1.3 1.0 1.3 1.4 1.4 1.3 1.3 1.5 1.4 1.5 1.1 1.2 1.2
Gavage ml
Day 29
1.2 1.2 1.1 1.4 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.4 1.3 1.0 1.3 1.4 1.4 1.3 1.3 1.5 1.4 1.5 1.1 1.2 1.2
Gavage ml
Day 30
1.2 1.2 1.1 1.4 1.3 1.4 1.3 1.2 1.4 1.4 1.3 1.4 1.3 1.0 1.3 1.4 1.4 1.3 1.3 1.5 1.4 1.5 1.1 1.2 1.2
Company Sanitized. Does not contain TSCA CBI
-370-
DuPont-9478
Gavage ml
Day 31
Gavage ml
Day 32
Gavage ml
Day 33
Gavage ml
Day 34
Gavage ml
Day 35
1.2 1.2 1.2 1.2 1.3 1.2 1.2 1.2 1.2 1.3 1.1 1.1 1.1 1.1 1.1 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.2 1.2 1.2 1.2 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.0 1.0 1.0 1.0 1.1 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.4 1.3 1.3 1.3 1.3 1.4 1-5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.1 1.1 1.1 1.1 1.1 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2
90-Day Oral Gavage StuidSyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 36
Gavage ml
Day 37
Female, X 125 mg/kg/day
655097 1.3 1.3 655052 1.3 1.3 655063 1.1 1.1 655103 1.4 1.4 655026 1.4 1.4 655095 1.4 1.4 655023 1.3 1.3 655007 1.3 1.3 655053 1.4 1.4 655092 1.4 1.4 655046 1.4 1.4 655027 1.4 1.4 655104 1.4 1.4
655106 1.1 1.1 655024 1.4 1.4 655037 1.4 1.4 655088 1.4 1.4 655010 1.4 1.4 655077 1.4 1.4
655030 1.5 1.5 655075 1.5 1.5 655100 1.5 1.5 655049 1.1 1.1 655084 1.2 1.2 655061 1.2 1.2
Gavage ml
Day 38
1.3 1.3 1.1 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.1 1.2 1.2
Gavage ml
Day 39
1.3 1.3 1.1 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.1 1.2 1.2
Gavage ml
Day 40
1.3 1.3 1.1 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.1 1.2 1.2
Gavage ml
Day 41
1.3 1.3 1.1 1.4 1.4 1.4 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.1 1.2 1.2
Gavage ml
Day 42
1.3 1.4 1.2 1.4 1.4 1.5 1.4 1.3 1.4 1.5 1.4 1.4 1.4 1.1 1.4 1.5 1.5 1.4 1.4 1.5 1.6 1.6 1.1 1.3 1.3
Company Sanitized. Does not contain TSCA CBi
-371-
DuPont-9478
Gavage ml
Day 43
Gavage ml
Day 44
Gavage ml
Day 45
Gavage ml
Day 46
Gavage ml
Day 47
1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.2 1.2 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.1 1.1 1.1 1.1 1.1 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.1 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3
90-Day Oral GavageUSJtSuduybcinhRroantsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 48
Gavage ml
Day 49
Female, X 125 mg/kg/day
655097 1.3 1.3 655052 1.4 1.3 655063 1.2 1.1 655103 1.4 1.4 655026 1.4 1.4 655095 1.5 1.5 655023 1.4 1.4 655007 1.3 1.3 655053 1.4 1.4 655092 1.5 1.4 655046 1.4 1.5 655027 1.4 1.5 655104 1.4 1.4 655106 1.1 1.1 655024 1.4 1.5 655037 1.5 1.5 655088 1.5 1.6 655010 1.4 1.5 655077 1.4 1.4 655030 1.5 1.6 655075 1.6 1.7 655100 1.6 1.6 655049 1.1 1.1 655084 1.3 1.3 655061 1.3 1.3
Gavage ml
Day 50
Gavage ml
Day 51
1.3
1.3 1.1 1.4.
1.4 1.5 1.4 1.3 1.4 1.4
1.5 1.5
1-4, 1.1
1.5 1.5 1.6 1.5 1.4 1.6 1.7 1.6 1.1 1.3 1.3
1.3 1.3
1.1 1.4 1.4
1.5 1.4 1.3 1.4 1.4 1.5 1.5 1.4 1.1 1.5
1.5 1.6 1.5 1.4 1.6 1.7 1.6 1.1 1.3 1.3
Gavage ml
Day 52
1.3 1.3 1.1 1.4 1.4 1.5 1.4 1.3 1.4 1.4 1.5 1.5 1.4 1.1 1.5 1.5 1.6 1.5 1.4 1.6 1.7 1.6 1.1 1.3 1.3
Gavage ml
Day 53
1.3 1.3 1.1 1.4 1.4 1.5 1.4 1.3 1.4 1.4 1.5 1.5 1.4 1.1 1.5 1.5 1.6 1.5 1.4 1.6 1.7 1.6 1.1 1.3 1.3
Gavage ml
Day 54
1.3 1.3 ICI 1.4 1.4 1.5 1.4 1.3 1.4 1.4 1.5 1.5 1.4 1.1 1.5 1.5 1-6 1.5 1.4 1.6 1.7 1.6 1.1 1.3 1.3
Company Sanitized. Does not contain TSCA CBI
-372-
DuPont-9478
Gavage ml
Day 55
Gavage ml
Day 56
Gavage ml
Day 57
Gavage ml
Day 58
Gavage ml
Day 59
1.3 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.1 1.2 1.2 1.2 1.2 1.4 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.5 1.6 1.6 1.6 1.6 1.4 1.4 1.4 1.4 1.4 1.3 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.4 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.1 1.1 1.1 1.1 1.1 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1,6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.4 1.5 1.5 1.5 1.5 1.6 1.7 1.7 1.7 1.7 1.7 1.8 1.8 1.8 1.8 1.6 1.4 1.4 1.4 1.4 1.1 1.1 1.1 1.1 1.1 1.3 1.3 1.3 1.3 1.3 1.3 1.4 1.4 1.4 1.4
( 9K0-DJaSy BOrBaliGmavKagjeSSutubdcyhinr Ro antsi c Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 60
Gavage ml
Day 61
Female, X 125 mg/kg/day
655097 655052
655063 655103 655026 655095 655023 655007
655053 655092
655046 655027
655104 655106 655024
655037 655088' 655010 655077 655030 655075 655100 655049
655084 655061
1.4 1.4
1.2 1.5 1.4 1.6 1.4 1.4
1.6 1.5
1.6 1.5 1.5 1.1 1.5
1.6 1.6 1.5 1.5 1.7 1.8
1.4 1.1 1.3 1.4
1.4 1.4 1.2 1.5 1.4 1.6 1.4 1.4 1.6 1.5 1.6 1.5 1.5 1.1 1.5 1.6 1.6
1.5 1.5 1.7 1.8
1.4 1.1 1.3 1.4
Gavage ml
Day 62
1.4 1.4 1.2 1.5 1.4 1.6 1.4 1.4 1.6 1.5 1.6 1.5 1.5 1.1 1.5 1.6 1.6 1.5 1.5 1.7 1.8 1.4 1.1 1.3 1.4
Gavage ml
Day 63
1.5 1.4 1.2 1.5 1.5 1.7 1.4 1.4 1.6 1.5 1.6 1.5 1.5 1.1 1.5 1.6 1.6 1.5 1.5 1.7 1.8 1.6 1.2 1.3 1.4
Gavage ml
Day 64
Gavage ml
Day 65
1-5 1.4.
1.2 1.5
1.5 1.7 1.4 1.4 1.6 1.5
1.6 1.5 1.5 1.1 1.5 1.6
1.6 1.5 1.5 1.7 1.8
1.6 1.2 1.3 1.4
1.5 1.4 1.2 1.5 1.5 1.7 1.4 1.4 1.6 1.5 1.6 1.5 1.5 1.1 1.5 1.6 1.6
1.5 1.5 1.7
1.8 1.6 1.2 1.3 1.4
Gavage ml
Day 66
1.5 1.4 1.2 1.5 1.5 1.7 1.4 1.4 1.6 1.5 1.6 1.5 1.5 1.1 1.5 1.6 1.6 1.5 1.5 1.7 1.8 1.6 1.2 1.3 1.4
Company Sanitized. Does not contain TSCA CBi
-373-
DuPont-9478
Gavage ml
Day 67
Gavage ml
Day 68
Gavage ml
Day 69
Gavage ml
Day 70
Gavage ml
Day 71
1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.2 1.2 1.2 1.3 1.3 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.7 1.7 1.7 1.7 1.7 1.4 1.4 1.4 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.6 1.6 1.1 1.1 1.1 1.2 1.2 1.5 1.5 1.5 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.6 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.4 1.4 1.7 1.7 1.7 1.6 1.6 1.8 1.8 1.8 1.8 1.8 1.6 1.6 1.6 1.6 1.6 1.2 1.2 1.2 1.2 1.2 1.3 1.3 1.3 1.4 1.4 1.4 1.4 1.4 1.4 1.4
90-_D_a_y__Oral Gavag_e_St^uSduybcinhrRoantisc Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 72
Gavage ml
Day 73
Female, X 125 mg/kg/day
655097 655052
655063 655103
655026 655095 655023 655007
655053 655092 655046 655027 655104
655106 655024 655037 655088
655010 655077 655030 655075 655100 655049 655084 655061
1.5 1.4
1.3 1.5
1.5 1.7
1.5 1.4
1.6 1.5 1.6 1.5 ' 1.6 1.2 1.6 1.6 1.6 1.5 1.4
1.6 1.8 1.6 1.2 1.4 1.4
1.5 1.4 1.3 1.5
1..5 1.7
1.5 1.4 1.6 1.5 1.6 . 1.5 1.6 1.2 1.6 1.6 1.6 1.5 1.4
1.6 1.8 1.6 1.2
1.4 1.4
Gavage ml
Day 74
1.5 1.4 1.3 1.5 1.5 1.7 1.5 1.4 1.6 1.5 1.6 1.5 1.6 1.2 1.6 1.6 1.6 1.5 1.4 1.6 1.8 1.6 1.2 1.4 1.4
Gavage ml
Day 75
1.5 1.4 1.3 1.5 1.5 1.7 1.5 1.4 1.6 1.5 1.6 1.5 1.6 1.2 1.6 1.6 1.6 1.5 1.4 1.6 1.8 1.6 1.2 1.4 1.4
Gavage ml
Day 76
1.5 1.4 1.3 1.5 1.5 1.7 1.5 1.4 1.6 1.5 1.6 1.5 1.6 1.2 1.6 1.6 1.6 1.5 1.4 1.6 1.8 1.6 1.2 1.4 1.4
Gavage ml
Day 77
1.5 1.4 1.3 1.5 1.5 1.7 1.5 1.5 1.6 1.5 1.7 1.5 1.6 1.2 1.6 1.7 1.6 1.5 1.5 1.7 1.8 1.7 1.2 1.4 1.5
Gavage ml
Day 78
1.5 1.4 1.3 1.5 1.5 1.7 1.5 1.5 1.6 1.5 1.7 1.5 1.6 1.2 1.6 1.7 1.6 1.5 1.5 1.7 1.8 1.7 1.2 1.4 1.5
Company Sanitized. Does not contain TSCA CBI
-374-
DuPont-9478
Gavage ml
Day 79
Gavage ml
Day 80
Gavage ml
Day 81
Gavage ml
82
Gavage ml
Day 83
1.5 1.5 1.5 1.5 1.5
1.4 1.4 1.4 1.4 1.4
1.3 1.3 1.3 1.3 1.3
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.7 1.7 1.7 1.7 1.7
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.7 1.7 1.7 1.7 1.7
1.5 1.5 1.5 1.5 1.5
1.6 1.6 1.6 1.6 1.6
1.2 1 .2 1 . 2 1 .2 1 . 2
.1.6 1.6 1.6 1.6 1. 6
1.7 1.7 1.7 1.7 1.7
1.6 1.6 1.6 1.6 1.6
1.5 1.5 1.5 1.5 1.5
1.5 1.5 1.5 1.5 1.5
1.7
1.7
1.7
1.7 '
1.7
1.8 1.8 1.8 1.8 1. 8
1.7 1.7 1.7 1.7 1.7
1.2 1 .2 1 . 2 1 .2 1 . 2
1.4 1.4 1.4 1.4 1.4
1.5 1.5 1.5 1.5 1.5
~90-Day Oral Gavage StuJSdyubinchRraotnsic Toxicity
INDIVIDUAL DOSE VOLUMES
Gavage ml
Day 84
Gavage ml
Day 85
Female, X 125 mg/kg/day
655097 1.6 1.6
655052 1.5 1.5 655063 1.3 1.3
655103 1.6 1.6
655026 1.5 1.5 655095 1.7 1.7
655023 1.5 1.5 655007 1.5 1.5 655053 1.7 1.7
655092 1.6 1.6
655046 1.7 1.7
655027 1.6 1.6 655104 1.6 1.6 655106 1. 2 1 . 2 655024 1.6 1.6
655037 1.7 1.7
655088 1.6 1.6
655010 1.5 1.5 655077 1.5 1.5
655030 1.8 1.8
655075 1.9 1.9 655100 1.7 1.7
655049 1. 2 1 . 2
655084 1.5 1.5 655061 1.4 1.4
Gavage ml
Day 86
1.6
1.5 1.3
1.6
1.5 1.7 1.5 1-5 1.7
1.6
1.7
1.6 1.6 1.2 1.6
1.7
1.6
1.5 1.5
1.8
1.9 1.7
1.2
1.5 1.4
Gavage ml
Day 87
1.6
1.5 1.3
1.6
1.5 1.7 1.5 1.5 1.7
1.6
1.7
1.6 1.6 1.2 1.6
1.7
1.6
1.5 1.5
1.8
1.9 1.7
1.2
1.5 1.4
Gavage ml
Day 88
1.6
1.5 1.3
1.6
1.5 1.7 1.5 1.5 1.7
1.6
1.7
1.6 1.6 1.2 1.6
1.7
1.6
1.5 1.5
1.8
1.9 1.7
1.2
1.5 1.4
Gavage ml
Day 89
1.6
1.5 1.3
1.6
1.5 1.7 1.5 1.5 1.7
1.6
1.7
1.6 1.6 1.2 1.6
1.7
1.6
1.5 1.5
1.8
1.9 1.7
1.2
1.5 1.4
Gavage ml
Day 90
1.6
1.5 1.3
1.6
1.5 1.7 1.5 1.5 1.7
1.6
1.7
1.6 1.6 1.2 1.6
1.7
1.6
1.5 1.5
1.8
1.9 1.7
1.2
1.5 1.4
Company Sanitized. Does not contain TSCA CB!
-375-
Gavage ml
Ddy 91
Gavage ml
Day 92
Gavage ml
Day 93
1.5 1.5 1.5 1.4 1.4 1.4 1.4 1.4 1.4 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6 1.6 1.5 1.5 1.5 1.6 1.6 1.6 1.7 1.7 1.7 1.6 1.6 1.6 1.8
1.6
1.6
1.3 1.6
1.7 1.6
1.6
1.5
1.7
1.8
1.7
1.2
1.4 1.4
DuPont-9478
^90-_D_a_y__O_r_a_l_G__a_v_a_g_e _S_tu^dSyubinchRroatnsi_c_T__o_x_ic_i_t_y
DuPont-9478
APPENDIX C INDIVIDUAL BODY WEIGHTS
-376-
Company Sanitized. Does not contain TSCA CB1
90-Day Oral Gavage Stu_dSyuibncRhraotnsic Toxicity
INDIVIDUAL BODY
Body weight g
Day 0
Male, I 0 mg/kg/day
gBody Weight Day 7
gBody Weight Day. 14
gBody Weight Day 21
gBody Weig] Day 28
654928 654993 654929
654972
654950 654953 654925
654987 654903 654966 654997 654971 654939 654919 654994 654949
654992 654909
654924
654943 654915 654927 654956 654910 654936
214.3 208.4 237.6 242.9
264.2 299.7 251.3
237.7 243.4
223.6 267.8 202.9 244.9 235.7 195.0 213.4 238.8 213.7
231.3 229.2 254.3
249.5 196.5 239.4 225.8
256.8 260.0 289.7 288.4
318.2 371.8 311.3 292.6 300.3 277.5 322'. 2 247.4 307.0 277.0 238.9 261.1 301.7 261.7 284.6
283.3 309.9 317.7 252.3
295.6 291.6
296.8
298.1 330.0 329.9
363.6 423.6 369.5
34^.3 345.0 318.5 372.9 294-7 363.7
317.6 286.9 307.6 357.0 307.7
326.7 329.5 360.2 374.1
298.7 358.6 355.5
346.6 337.2 367.3 369.6 409.3
483.6 418.0 387.3 397.7 ' 360.3 412.9
351.2 416.4 358.5 327.9 349.8 410.3 344.3 372.7 362.2 407.8 426.9
340.8 421.7 410.2
390.4 362.3 396.1 393.9 .439.0 536.8 448.0
395.9 441.1
397.0 437.5 391.9 443.1 384.9 360.9
379.3 438.2 376.1
412.2 390.6 446.7
460.2
369.3 446.5 450.2
Company Sanitized. Does not contain TSCA CBI
-377-
DuPont-9478
WEIGHTS
Body Weight
g g gDay 35
Body Weight Day 42
Body Weight Day 49
Body Weight g
Day 56
428.1 391.9 421.9 415.9
461.3 575.9 486.3 447.2 471.9
341.5 462.9
434.8 483.4 407.4 384.2 410.4 469.5
403.6 439.8 419.6 481.7
495.5 406.5 492.5 492.6
457.1 407.2 433.4 434.4
482.9 607.2
502.6 474.3 492.3
313.3 483.8 460.9
519.7 425.5 407.0 428.7
495.8 429.8 477.3
441.8 514.4 517.6 428.6 521.4 524.2
469.5 417.1 441.4
441.6
482.8 607.1
517.9 483.9 503.8
374.6 496.6 482.4 550.9 438.6 414.0 450.7
521.8 451.6
485.8 457.7 531.3
543.9 444.8 550.1
521.3
500.8 448.9 471.7 457.5
499.7 638.8 537.5 505.4 529.8 384.8 514.7 497.2 568.9
461.3 402.4 475.9 550.4
467.0 503.0 467.7 557.3 568.1 466.0 576.8 542.6
90-Day Oral Gavag_e__StuldSyubinchRraotnsic Toxicity
}
DuPont-9478
INDIVIDUAL BODY WEIGHTS
gBody Weight Day 63
Male, I 0 mg/kg/day
gBody Weight Day 70
gBody Weight Day 77
gBody Weight Day 84
gBody Weight Day 91
gBody Weight Day 93
gBody Weight Day 98
gBody Weight Day 105
gBody Weight Day 112
654928 654993 654929 654972
654950 654953
654925 654987 654903 654966 654997 654971 654939 654919
654994 654949 654992
654909 654924 654943
654915 654927 654956 654910 654936
530.1
468.0 487.0
472.9 512.6 660.1
550.6
528.0 545.6 380,8 525.5 512.1 575.1 477.5 423.2 501.7
563.4 486.1 522.5
486.8
574.5 579.3 481.9 601.7
566.6
547.1 482.5 501.2
481.8 525.2 680.6 563.0
539.3 569.4
424 .'8
545.8 536.1 591.0 489.2 450.4
522.0 575.8 497.3 539.2
498.5 589.8 600.7 485.2 619.5
588.9
556.8 494.9 510.6
492.8 512.9 692.0
566.9 556.6 580.8 442.1 557.7 545.6 606.1 500.0
458.3 527.7 586.2 510.6 544.7 510.0
603.9 614.1 495.9 626.5 597.8
574.1 500.9 516.0
499.3 526.8 698.3 584.1
571.1 589.2 454.8 562.0 558.3 617.0 498.7
460.1 533.7
596.6 520.6 532.7
515.6 611.7 614.3 494.7
626.6 606.8
586.7 507.2 525.3
512.3 548.5
659.9 596.2
580.5 603.1
468.7 572.4 562.4 629.9 504.1
466.3 539.1
601.6 529.1
556.8 516.4
619.4 621.7 498.9 634.7
609.6
566.3 486.8 506.1 498.8 520.7 646.3 575.8 566.4 578.5
583.7
493.6 578.2
577.3 634.9 511.2
484.7 557.8
609.5 535.1 576.1 538.5
630.0 632.3 509.8 651.9
448.9 586.1
543.7 . 647.2 509.2 497.1 563.7 626.5 554.8 592.2 552.2
652.6 644.8 519.9 660.8
473.1 606.2 . 548.7 660.2 511.3 503.0 572.9
636.3 567.2 597.0 551.0
653.6 656.2 523.1 664.9
Company Sanitized. Does not contain TSCA CBI
-378-
90-Day Oral Gavage StuPdSyuibncRhraotnsic Toxicity
') DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
_D aygg 1_.1_9
gg Day 126
Male, I 0 mg/kg/day
Body Weight gg
Day 133
Body Weight Body Weight
gg Day 140
gg Day 147
Body Weight gg
Day 154
Body Weight og
Day 161
Body Weight g
Day 168
Body Weight
g Day 175
654928 654993 654929
654972 654950 654953 654925 654987 654903 654966 654997 654971
654939 654919
654994 654949 654992 654909
654924 654943 654915 654927 654956 654910
654936
490.9 610.7
576.2 676.0 518.5
508.7 579.9 644.3 567.2 605.2 560.2 666.4 657.3 529.0 673.5
52315 628.5 591.9 687.7 526.4
520.9 586.7
662.5 572.5 619.4 569.7 680.4 671.8 547.3 693.8
541.4 632.0 600.3 697.7 533.1 527.8 597.1
661.3 576.4 627.6 583 .'3 697.0
684.3 553.9 692.3
540.8 619.5 590.3 712.4 528.9 520.0 597.8 656.4 576.1 623.0 585.5 694.1
685.2 555.6 694.4
552.8 624.7 576.7 715.1 529.8
526.3 602.4 659.4 578.9 629.5 592.9 705.6
693.8 562.9 707.3
537.5 635.0 598.8 728.6 541.7 530.6 606.8 669.6 583.4
628.6 605.6 721.5 703.9 572.1 710.7
509.9 643.9
572.2 738.8 544.9
529.5 609.7
667.7 592.2
637.3 609.7
723.0 691.9 574.0 .
710.7
528.0
649.3 577.9 741.9 548.7
536.6 613.3
674.5 591.0 647.6 621.5
732.9 701.9 570.5 712.0
489.7
655.1
575.7 743.6
551.1
5 3 5 .8
614.7
683.7 593.7
658.7 625.5
751.4
703.2
569.6
718.8
Company Sanitized. Does not contain TSCA CB1
379
Company Sanitized. Does not contain TSCA C81
90-Day Oral Gavage StJudSyuibnchRraotnsic Toxicity
Body Weight Body Weight
g Day 182
g Day 183
Male, X 0 mg/kg/day
654928
654993 654929
654972 654950
654953 654925 654987
654903 654966
654997 654971 654939 654919 654994
654949 654992 654909 654924 654943
654915 654927 654956
654910 654936
?
543.9 623.7 680.7 598.6 658.6 631.2 754.8 697.7 570.9
715.8
521.1 601.2
656.3 578.3 631.4 605.8
725.9 674.6 551.9 691.5
INDIVIDUAL BODY WEIGHTS
-380-
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
g Day 0
g Day 7
Male, :III 1 mg/kg/day
Body Weight g
Day 14
Body Weight g
Day 21
Body Weight g
Day 28
Body W3eight
Day 35
Body Wgeight
Day 42
Body Wgeight
Day 49
Body gWeight
Day 56
654913 654947 654995 654938 654941 654946 654960
654908 654984 654932
654948 654904 654954 654945 654988
224.8
221.2
230.5 250.0 241.2
271.8 283.0
255.8 236.4 252.4
255.3 233.0 272.2 217.1
239.2
280.3 273.5 287.2 311.2 305.9
337.5 325.6 302.9 302.8 31-4.8 315.7 281.2 319.0 236.8 292.9
334.3 323.4 342.4 367.5 358.2
393.7
361.3 356.4 352.7
365.7 372.2 336.5 363.6 314.6 347.1
376.2
361.7 381.4 415.0 404.4 436.3 401.6 396.6 396.1 413.7
417.5 370.5 411.7 352.0
388.8
410.8 391.3 411.4
441.2 437.0
465.8 417.9 438.4 437.7
441.8 454.2 401.4 448.5 376.1 416.7
436.6 416.2 446.8 467.2 468.2
501.0 440.7 458.1 471.7
467.5 489.5 436.5 481.4 400.2 444.2
464.0
433.4 469.3 493.6 472.2
525.5 457.6 476.0
491,5 493.2 512.0 459.5 511.7 412.7
465.0
473.1 445,9 472.3 504.9 476.9 532.1 455.4 475.4
501.5 500.2
524.8 477.7 530.1 425.4 478.9
499.7 467.2 495.0 527.8
498.0
556.7 484.5 503.2 535.5 519.1 542.7 490.4 557.7 443.3 505.9
Company Sanitized. Does not contain TSCA CBI
- 381 -
0 90-Day Oral Gavage St_udSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
9 Day 63
g Day 70
Male, III 1 mg/kg/day
Body Weight g
Day 77
Body Weight g
Day 84
Body Weight g
Day 91
Body Weight g
Day 93
Body Weight g
Day 98
Body Weight
g Day 105
Body Weight g
Day 112
654913 654947
654995 654938 654941
654946 654960 654908 654984
654932 654948 654904 654954 654945 654988
515.5
479.9 508.9 552.8
514.0 568.8 498.9 510.6 556.7 533.5 561.4
500.8 574.5 454.4 517.3
537.1
491.3 532.7
570.4 533.4
596.3 512.7 513.9 584,5 554.7 574.7 511.7 590.1 455.1 529.9
546.9
502.3 529.8 576.3
543.9
598.8 522.9
529.7 594.0 561.5
543.2 528.4 593.5 464.4 535.8
537.9
503.4 526.5 574.6 524.3
599.0 529.5 532.0 607.4 570.6
587.4 532.0 600.9 471.9 545.4
557.6 509.0
528.2 600.7 540.3
595.3 540.5 541.0 623.1
584.8 610.0
543.5 611.1 474.7
554.9
534.1 489.6 514.1 579.4 515.8 577.7 513.2 516.1 601.8 566.1
'
625.3 551.0 618.2 480.0
565.1
640.9
563.6 636.0 497.2 576.4
649.3 565.5 '635.0 498.1
573.9
Company Sanitized. Does not contain TSCA CB1
-382-
9_0__-D__a_y O__r_a_l _G_a_v_a_g_e__StuIdSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
9 Day 119
3 Day 126
Male, III 1 mg/kg/day
Body Weight g
Day 133
Body Weight g
Day 140
Body Weight g
Day 147-
gBody Weight Day 154
gBody Weight Day 161
gBody Weight Day 168
gBody Weight Day 175
654913 654947 654995 654938 654941
654946
654960 654908 654984 654932 654948 654904 654954 654945 654988
661.4
576.0 642.5 514.3 580.9
674.0
590.0 661.2 511.1
586.0
689.4 601.9
661.0 529.0
594.5
699.6
598.8 661.2 532.4 586.9
713.9
606.3 674.3 540.4 597.1
721.2 614.0 680.2 553.0
607.6
727.0 613.7 683.1 553.0 609.3
729.2 619.9 687.6 562.3
612.5
738.3
616.7 690.9 572.6 613.2
Company Sanitized. Does not contain TSCA CBI
-383 -
_9_0_-_D__a_y_O__ra_l_G___v_a_g_e_StujSduybicnhRroantisc__T_o_x_i_c_it_y
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight g
Day 0
Male, V 5 mg/kg/day
Body Weight g
Day 7
Body Weight
g Day 14
Body Weight
g Day 21
Body Weight g
Day 28 '
Body Weight
g Day 35
Body Weight
g Day 42
Body Weight
g Day 49
Body Weight g
Day 56
655005 654907 654980
654959 654961 654916 654911 654917 654998
654970 654926 654918 654981 654969 654967
235.1
226.4 227.0
249.3 268.1 275.8 260.6 238.8 248.3
213.2 269.8 243.5 208.9 227.6
220.2
288.9 281.8 289.9
309.6
330.2 333.7 327.3 298.7 311.9 249 I 9
320.4 297.7 260.2 261.4 275.8
345.7 333.3 348.4 366.6 396.3 375.8 388.8 355.2 368.1
285.6 369.1
350.8 316.9 297.3
327.9
400.1
375.6 405.5 424.4 452.5 413.1 439.2 400.3 415.5 325.6 423.4 399.6 368.8 330.8 367.7
439.5 405.3 448.1
474.2 497.7 441.6 486.0 426.6 453.5
353.2 467.2 435.4 394.6 360.3 399.2
470.0 433.5 487.2
504.7 537.0 466.1 517.7 457.5 489.3
372.3 509.6 471.6 424.1 390.2
428.5
498.9 453.0 522.5 536.3 552.1 478.3 546.5 497.5 519.9 385.7 529.6 493.6 435.9 414.9
446.3
509.4
455.9 535.6 547.4 558.7 491.4 539.7 508.7 518.5 399.8
554.3 518.5 453.2 433.9 451.7
538.2 493.7 576.4
572.2 600.3 514.0 566.6 536.4 550.2 413.6 574.7
545.7 469.9 456.8
478.5
Company Sanitized. Does not contain TSCA CBI
-384-
INDIVIDUAL BODY WEIGHTS
Body Weight g
Day 63
Male, v 5 mg/kg/day
Body Weight g
Day 70
Body.Weight g
Day 77
Body Weight g
Day 84
Body Weight g
Day 91
Body Weight
g Day 93
Body Weight g
Day 98.
Body Weight
g Day 105
Body Weight
g Day 112
655005 654907 654980 654959
654961 654916 654911 654917
654998 654970
654926 654918 654981 654969 654967
565.3 510.3 597.7
600.2 621.6 519.9 591.9 568.1
565.0 429.4 589.1
569.9 483.1 468.4 496.6
576.2
520.3 607.4
613.6 642.9 516.2 606.7 580.2 575.8 451.8 606.6
590.0 500.8 489.6 508.2
589.4 530.4 630.1
623.7 653.1 522.9 622.8 597.8 598.2 474.4 598.7
596.8 503.8 505.5 518.3
596.5 544.2 645.1 633.9
666.1
544.1 638.2 600.9
617.8 481.7
614.0
610.1 513.0 508.3 523.8
587.6 553.5 661.6 649.1
672.7 550.2 638.0 63.3
608.2 477.3
641.3 619.2 524.7 511.5 528.0
567.8 532.9 626.5 621.1 643.3 526.3 619.9 587.8 587.6
513.3
496.9
651.0 632.2 530.5 , 524.5
508.6 657.1
646.2 531.6 534.4
513.4 667.4
648.6 540.8 525.8
Company Sanitized. Does not contain TSCA
O CD
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight g
Day 119
Male, V 5 mg/kg/day
Body Weight 9
Day 126
Body Weight g
Day 133
Body Weight g
Day 140
Body Weight g
Day 147:
Body Weight g
Day 154
Body Weight g
Day 161
Body Weight g
Day 168
Body Weight g
Day 175
655005 654907
654980
654959 654961
654916 654911
654917 654998
654970 654926 654918 654981 654969 654967
517.6
675.5 667.3 550.7 542.0
529 !2
691.2 669.2 560.0 553.3
535.6
697.0
686.6
572.5 558.1
532.9
703.6
699.5 575.7 528.4
540.7 719.7
704.8 577.1 549.4
550.4
718.6 713.5 588.5 564.5
545.6
724.1
719.0 589.1 569.6
546.2 726.6 727.2 585,3 569.9
542.4
722.1
726.8 589.1 582.0
Company Sanitized. Does not contain TSCA CBI
-386-
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
9 Bay 0
g Day 7
Male, VII 25 mg/kg/day
Body Weight
g Day 14
Body Weight g
Day 21
Body Weight g
Day 28
Body Weight 9
Day 35
Body Weight
9
Day 42
Body Weight g
Day 49
Body Weight g
Day 56
655001
654975 654922 654940
654930 654958 654952 654923 654989
655006 654920 654912 654934 654964 654933
230.8 219.2 218.7
238.9 238.0
248.9 277.3 251.5 236.3 251.9
227.9 217.7
235.0 252.8
245.5
290.9
275.1 270.6
296.2 305.2
290.8 334.9 308.3 297.2
310.4 274.7 264.6 294.2 307.4
302.8
348.1
327.6
3-17.5 340.6
360.9 325.6 390.1
363.6 357.6
363.7 325.5 305.4 334.8 357.6
364.8
417.7
378.0
366.2 387.5 416.1
358.7 437.8 412.8 399.0 409.5 376.6 339.8 371.1 405.7
420.4
470.7
410.7 400.7
414.2 464.1 382.3 459.7 447.4 438.7
440.2 416.1 364.9 396.6 443.2 457.7
517.2 433.2
433.9 442.2
502.8 409.2 494.7 477.5 469.4 467,9 448.6 395.6 433.3 480.6 506.4
543.8 467.4
469.1
467.8 534.6 432.1 523.0 498.3 496.0 495.4 475.6 423.6 455.8 510.9
543.9
552.5
473.0 480.1
474.4 542.1 439.1 526.6 503.8 503.6 500.1 491.0 441.8 474.9
534.2 578.7
588.9 502.7
523.7 496.5 566.8 454.9 556.7
519.7 533.0 522.7 523.6 466.6 500.1 558.2 613.0
Company Sanitized. Does not contain TSCA
O00
-387-
'ral G_a_v_a_g_e_SStuudbychinroRnaictsToxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
gg
Day 63
Day 70
Male, VII 25 mg/kg/day
Body Weight 3
Day 77
Body Weight g
Day 84
Body Weight
g Day 91
`
Body Weight
g Day 93
Body Weight
g Day 98
Body Weight
g Day 105
Body Weight
g Day 112
655001
654975 654922
654940 654930 654958 654952 654923 654989 655006 654920 654912 654934 654964
654933
612.3 530.6
543.4 516.2 584.3 471.2
576.2 533.3 557.2
542.3 540.6 488.8 510.8 576.1
636.1
630.5 542.1 555.8
529.8 597.7 480.7 575.4 533.8
565.1 549 1
549.9 504.1 520.1 590.3
651.0
641.2 553.4
572.5 543.7 598.8 486.6 592.7 548.5 582.9 556.4 560.1 527.0 531.3 604.1
668.5
646.1
558.9 580.3 542.2 602.4 496.9 617.2 560.9 600.2 573.2 576.8 532.7
544.2 611.0
674.3
661.8 580.6 583.5
554.6 619.4 506.6 620.7 566.3
612.7 575.2 588.0 531.7 554.7 627.4
685.4
641.7
554.9 555.6 534.8 596.1 483.1 598.4 539.3
580.5 557.0
591.8
543.3 566.6 639.7
692.4
602.8
551.8 571.7 646.5
700.4
607.2
554.7 563.4 655.8 715.2
Company Sanitized. Does not contain TSCA CBI
-388-
0 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body WOgeight
Day 119
Body CglWeight Body Wrgeright
Day 126
Day 133
Male, VII 25 mg/kg/day
Body Wrge,ight
Day 140
Body Wg,,eight
Day 147
Body W~geight Body Wg.eight
Day 154
Day 161
Body Weight g
Day 168
Body Weight g
Day 175
655001 654975 654922 654940 654930 654958 654952 654923 654989 655006
654920 654912 654934 654964
654933
619.8
555.9 583.1 662.7 732.1
638.2
576.0 591.9 674.0
752.0
648.3
581.7 597.4 679.4 767.0
642.3
580.2 604.5 681.3 775.5
652.4
590.0 607.1
687.5 791.1
672.1 606.0 616.0 702.3 811.1
676.8
595.3 614.4 701.3 806.9
680.0 617.5 616.4
717.7 821.9
688.0
622.5 618.7
723.2 816.8
Company Sanitized. Does not contain TSCA CBI
-389-
90-Day Oral Gavage StuJSdyubinchRroatnsic Toxicity
INDIVIDUAL BODY
Body Weight Body Weight
gg
Day 0
Day 7
Male, IX 125 mg/kg/day
Body Weight g
Day 14
Body Weight g
Day 21
Body Weight g
Day 28
654983
654965 654979,
654986 655003
654921 654996
654951 654955 654914 654937 654962 654982 654931
654906
654985 654978 654974
654990 654976 654957
654973 654977 654942 654991
236.6 211.9
218.3 243.8
231.8
269.5 275.4
248.9
238.8 248.3 234.6 266.3 222.9 240.9 248.1
194.0 201.7 214.6 234.9 ,216.4 253.6 261.7 194.1 234.0 236.1
298.9 260.9 273.2 295.7
278.0 323.2 325.6
296.2 310.9
298.'9 298.6 299.4 280.1 301.6
316.0 233.5 248.2 276.1 290.2 269.2 308.8
316.6 232.0 286.6 311.4
351.7 315.8
329.8 346.1
334.5 377.7 371.5
349.4 376.9 344.1
358.5 353.6 338.7 364.4
379.6 274.6 291.0 334.6 336.2 326.6
360.2 368.2 285.7 339.5 374.3
396.7
357.0 363.5
405.8 374.5
416.7 400.9
392.1
428.6 383.8 409.9
406.5 386.1 421.9
438.7
318.9 329.7 378.2 373.7 373.6
400.5 411.9 321.6 377.2 429.1
437.1 393.1
391.5
444.3 401.3 454.1 426.4
430.6 462.1
414.0 446.6 443.9 419.8 462.7 476.0
345.1 357.4 421.2 415.0 404.8 431.4 446.6 344.5 403.1 476.6
Company Sanitized. Does not contain TSCA CBI
-390-
DuPont-9478
WEIGHTS
Body Weight Body Weight Body Weight Body Weight
g gg g
Day 35
Day 42
Day 49
Day 56
470.5 412.9 423.4
480.5
421.6 481.8 454.4
456.4 490.2 441.9 476.5 472.2 456.2 496.5 516.8 359.8 378.7 447.9 440.9 424.6 449.4
465.3 367.9 425.9 509.2
504.4 438.7
446.2
516.1 449.2 501.6 460.2
487.3 513.9 475.5 500.0 485.6 477.5 519.5 550.3
387.4 398.2 471.4 462.8 455.3 469.0 488.9 388.8 455.8 540.8
510.9 438.7 459.9
518.9
456.5 503.4 457.6
499.1 522.5 486.5 518.8 505.6 500.1 541.3 581.1
395.9 410.4 488.3 481.6 469.7 493.1 496.6 404.3 462.4 566.0
'
530.4 442.8 484.1
553.3 473.7 533.9 485.6
522.7 544.3 503.8 538.8 530.0 527.8 562.7 607.8 416.2 430.3 506.6 495.4 482.4 505.7
510.2 414.4 484.5 593.6
t90-Day Oral Gavage__S_tu_dSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
9g
Day 63
Day 70
Male, IX 125 mg/kg/day
Body Weight 9
Day 77
Body Weight g
Day 84
Body Weight 9
Day 91
Body Weight Day 93
Body Weight
g Day 98
Body Weight
g Day 105
Body Weight g
Day 112
654983 654965 654979 654986 655003 654921
654996 654951 654955 654914
654937 654962 654982 654931 654906 654985 654978 654974 654990
654976 654957 654973 654977
654942 654991
555.0 462.0 497.6 538.3 486.4
546.9 462.4 541.0 557.4
516.7 557.9
536.4 519.9 569.0 623.5 427.9
4 4 3 .6
528.9
516.2
438.9 516.7 523.6
425.4
500.3 606.9
559.3 478.9
516.0
508.0 499.3 553.6 485.1 552.8 571.8
53-8.0 564.1 561.4
536.7 537.5 647.3 435.0 456.5 520.9
529.9
486.5 519.5 527.8 414.0
503.6 608.1
570.3 460.1
522.0
493.1 500.1 570.7
495.8 558.1 562.0
553.7 576.3 561.9 511.2 464.6 641.8 369.9 456.3 438.2
537.5 484.2 529.4 548.4
427.8 512.1
616.5
574.4 488.1'
525.7 536.4 511.6 567.4 520.6 565.7
533.8 576.1 569.1
545.9 501.1 541.0 639.7 388.5 464.9 497.8 555.9
506.1 537.3 557.3 441.9
513.0
629.3
596.3 510.5 546.5
605.1 530.9
579.7 534.8 573.2
568.1 591.0 581.8
550.5 531.5 559.7 672.1 421.4 484.4 533.0
583.6 531.0
544.9 560,7 444.1
522.3
639.3
569.9 483.6 512.4
575.0 506.1 553.2 508.6 555.0
542.5 563.5
588.8 570.6 533.4 580.1 687.9 430.8 499.1 560.5
589.4 539.0
556.5 566.6
456.9 528.5
651.3
611.2 580.8 543.9 600.7 713.8 441.1 504.3 566.6
592.8 549.0
558.9 579.8 472.5
536.8
665.5
622.2
579.7 564.9 608.1 712.5 446.5 514.1 579.6
587.6 542.4 568.3 587.2 477.4
542.3
669.6
Company Sanitized. Does not contain TSCA CBJ
-391 -
90-Day Oral Gavage_S_t_uSdyubicnhRroantsic Toxicity
)
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
gg
Day 119
Day 126
Male, IX 125 mg/kg/day
gBody Weight Day 133
gBody Weight Day 140
gBody Weight Day 147'
gBody Weight Day 154
gBody Weight Day 161
gBody Weight Day 168
gBody Weight Day 175
654983 654965 654979
654986 655003 654921 654996 654951 654955
654914 654937 654962 654982 654931
654906 654985 654978 654974
654990 654976 654957 654973
654977 ' 654942 654991
633.6 581.9 575.0 610.9 734.9 451.3
513.6 585.4
603.0 558.7 581.2 602.5 482.1
551.5 683.4
657.6 594.1 584.2 627.6
758.8 449.4 535.0 606.4 621.5 574.2 588.9 612.2
496.5 574.4 708.6
665.9 596.4 595.4 642.0 777.3 451.7
540.1 625.0 639.3 574.9
604.5 630.7 501.9 582.6 726.6
670.1 592.2 613.8 645.2 773.5 456.4
539.3 633.9
631.2 580.7
612.3 637.0 492.8 579.4 735.7
684.6 595.8 627.8 653.8
778.0 460.7
545.5 640.1
648.9 587.1 619.2 648.2
494.6 595.1 742.9
704.4 606.0 636.5 672.1
785.7 492.5 556.7 658.8 668.4 601.1
623.5 660.9 504.0 608.9 756.1
703.1
613.0 646.3 678.2 786.0 490.3
562.6 662.0
678.0 593.9 619.8 656.9 499.0 606.2 752.7
725.9 626.7 678.3 690.1 796.4 498.5
566.6 683.2 690.1 605.5 617.9 665.0 502.2 624.6 766.2
704.7
623.3 667.9 692.3 801.5 498.8 565.4 685.6 682.1 603.8 622.2 662.4 508.4 630.8 772.8
Company Sanitized. Does not contain TSCA CBI
-392-
Company Sanitized. Does not contain TSCA CBi
P9-0-Da--y Oral Gavaige StuSdyubicnhRroantsic Toxicity
Body Weight Body Weight
9 Day 182
3 Day 183
Male, IX 125 mg/kg/day
654983 654965 654979
654986 655003 654921 654996 654951
654955 654914 654937
654962 654982 654931 654906 654985
654978 654974 654990 654976 654957 654973 654977 654942
654991
505.5 572.6 702.9 694.3 613.5 635.5 669.1
517.4 651.0
784.9
475.3
552.6 673.0 667.9 597.1 616.9 642.7 492.6
620.8 759.7
INDIVIDUAL BODY WEIGHTS
-393 -
)
DuPont-9478
90-Day Oral Gav__a_ge_S_tuj dSyuibnchRraotnsic Toxicity
INDIVIDUAL BODY
Body Weight Body Weight
gg
Day 0 ,
Day 7
Female, II 0 mg/kg/day
Body weight g
Day 14
Body Weight g
Day 21
Body Weight g
Day 28
655031 655107 655098
655016 655079 655036 655025
655099 655032 655083
655093 655045 655065 655074 655035 655009 655068
655019 655062 655109 655101 . 655072
655015 655071
655022
174.3 174.0 163.3 .
181.5 174.1
214.7 179.5 195.9 200.4 203.8 163.7 183.9 188.4 193.6 181.4 177.0 200.3
200.2
191.7 191.6 208.8 204.6 155-1 179.2
183.5
187.9
190.1
181.6
199.3 183.3
232.8 203.7
212.1
213.9
220'. 3 168.4
202.2
207.9
219.9
202.6
195.3
217.0 218.6 203.6 210.7
238.4 233.3
172.4
202.6
201.9
207.2 199.3 203.1
212.7 194.9
252.5 226.1
242.5 223.6
234.0 180.5 226.7 229.5 236.5 220.7 219.0 242.1 247.3 231.5 235.9 261.6 248.9 190.9 196.4
224.1
229.7 206.5 216.3 218.3 205.2 266.2 247.6 256.9 245.6 250.7 193.1 241.9 247.0 259.4 242.6 241.5 257.9 270.2 245.1 247.7 285.8 271.7 198.2
240.6
251.4 214.1 222,5 233.8
220.2
285.0 257.6 267.1 256.0 259.0 194.9 244.2 260.7 262.8 252.3 252.2 267.9 276.3 261.1 256.6 302.3 286.4 198.6
259.0
Company Sanitized. Does not contain TSCA CBI
-394-
DuPont-9478
WEIGHTS
Body Weight Body Weight Body Weight Body Weight
gggg
Day 35
Day 42
Day 49
Day 56
257.8 219.5 232.1 239.1 233.0 299.1 271.3 276.4 266.2 275.1
200.1
261.1 283.5 278.2 273.5 261.2 285.5 289.9 268.9 267.9 313.6 286.7 218.9
265.9
275.0 226.9 241.5 255.6 242.5 301.2 283.8 287.8 282.4 280.2 207.3 269.7 296.5 286.9 276.0 265.4 284.5 299.1 275.4 278.6 329.7 305.4 231.9
269.6
267.8
220.2
239.1 251.6 238.2 294.8 277.1 276.3 278.3 278.2 209.2 271.6 305.1 284.7 285.0 274.4 287.2 301.6 280.1 279.1 338.2 312.0 223.5
274.9
285.6 234.4 246.0 269.8 258.4 315.7 295.7 292.3 298.1 295.8 213.2 274.5 314.5 284.1 294.3 286.6 294.4 311.8 288.9 288.1 344.1 320.4 232.5
286.4
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
gBody Weight Body Weight g
Day 63
Day 70
Female, II 0 mg/kg/day
gBody Weight Day 77
gBody Weight Day 84
gBody Weight Day 91'
Body Weight 3
Day 94
Body Weight 3
Day 98
Body Weight 3
Day 105
Body Weight 3
Day 112
655031 655107 655098
655016 655079
655036 655025 655099 655032
655083
655093 655045 655065 655074 655035 655009
655068 655019 655062 655109 655101 65E>072
655015 655071
655022
287.2 234.3 250.9 282.6 259.3 320.5 299.9 289.8 300.1 297.3 213.3 286.6 326.0 294.0 297.8 292.2 294.0 315.8 289.7 292.5 362.5 315.2 239.8
288.6
301.3 245.5 265.5 282.6 267.0 325.7 317.2 299.5 302.4
308'. 8
224.2 294.4 340.7 297.4 298.4 296.4 301.7 321.1 299.9 299.7 358.6 330.2 240.4
288.5
306.4 245.3 264.8 289.4 272.3 329.4 319.9 302.1 312.1 314.7 231.1 294.5 339.3 309.5 305.0 294.5 298.5 322.6 310.2 297.9 366.5 331.2 241.0
293.9
309.2 251.9 266.3 301.1 276.4 337.3 315.7 302.9 300.8 324.0 229.4 289.8 340.2 308.2 311.2 304.3 306.0 322.2 315.2 304.2 374.1 328.6 243.8
296.6
300.2 250.1 268.3 296 ^1 282.0 338.7 320.7 302.1 317.3 326.0 229.3 300.5 352.2 305.0 311.1 312.4 298.6 326.5 312.1 306.9 366.5 323.7 250.5
293.1
292.6 238.5 261.1
286.5 266.8
322.5 301.7 284.9 302.9
310.8
236.7 298.2 356.0 305.9 309.7 314.7 304.6 331.7 319.9 308.1 381.8 343.4 240.0
301.2
234.5 313.2 362.6 318.1 321.4 318.5 317.5 333.1 332.4 311.4 381.9 338.9 238.1
298.9
234.7 310.9 365.0 316.0 324.8 328.3 324.2 332.0 330.9 308.5 377.8 340.7 251.4
306.5
Company Sanitized. Does not contain TSCA CBi
-395-
90-Day Oral Gavage Stu}dSyubinchRraotnsic Toxicity
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
3g
Day 119
Day 126
Female, II 0 mg/kg/day
Body Weight g
Day 133
Body Weight g
Day 140
gBody weight Day 147
gBody Weight Day 154
gBody Weight Day 161
gBody Weight Day 168
gBody Weight Day 175
655031 ' 655107 655098 655016 655079
655036 655025 655099
655032 655083 655093 655045 655065 655074
655035 655009
655068 655019
655062 655109
655101 655072 655015 655071
655022
237.8 306.1 377.4 316.1 321.1 324.2 319.7 337.2 342.1 313.5 375.5 338.6 265.3
308.3
240.9 307.3 377.0 325.7 333.2 328.7 327.1 340.5 358.8 320.8 387.9 356.0 278.6
308.3
242.9 305.7 372.3 326.9 331.8 327.4 330.8 343.9 349.0 314.9 404.7 357.5 286.1
310.5
246.6 308.7 377.4 336.3, 331.6 334.2 335.3 353.9 353.1 321.0 395.7 345.5 290.3
312.4
246.5 321.1 387.8 341.1 335.3 338.5 340.5 352.2 349.6 324.8 411.0 360.6 295.2
313.4
248.8 325.4 395.2 341.4 319.6 339.4 339.7 362.1 358.0 328.8 409-.7 366.4 300.7
315.4
245.3 321.9 376.6 338.8 313.6 331.8 339.1 352.3 355.0 321.5 400.7 354.9 299.2
316.4
249.3 330.4 371.7 348.9 326.8 337.9 347.8 362.7 365.4 322.9 413.7 354.0 313.1
320.1
252.5 336.3 378.0 345.8 329.5 338.1 347.0 365.3 367.3 326.1 420.9 360.7 308.3
316.9
Company Sanitized, Does not contain TSCA CBI
-396-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
Body Weight Body Weight
g Day 182
g Day 183
Female, II 0 mg/kg/day
655031 65507
655098
655016 655079 655036 655025
655099 655032 655083 655093 655045 655065 655074 655035 655009
655068 655019 655062 655109 655101 655072 655015 655071
655022
343.5 329.2
352.1 370.7
371.5 328.7 420.5 364.0 306.9
322.8 317.1
329.8 347.7 344.4 309.3
405.9 340.9 288.4
INDIVIDUAL BODY WEIGHTS
-397-
>
DuPont-9478
O90h-DBayMOraBl GHavBageWStudSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
g Day 0
g Day 7
Female, IV 1 mg/kg/day
Body Weight g
Day 14
Body Weight g
Day 21
Body Weight g
Day 28'
Body Weight
g Day 35
Body Weight
g Day 42
Body Weight
g Day 49
Body Weight
g . Day 56
655086 655041 655108 655040 655044
655013 65508.9 655091
655033
655090 655051 655018 655096 655057
655028
172.1
186.9 168.1
182.6 177.2
201.2
152.0
181.2 194.4
211.0
171.3 203.4 199.8 161.4
.195.0
191.8 192.1
192.3 205.2 203.1
231.3
200.2
207.8 214.2
235.2 191.4 220.4 206,0 183.4
211.3
209.5 209.7
213.6 229.5 230.9 254.4
221.6
221.3 232.0 250.7
205.2 239.6 225.0 203.6 224.9
218.3 229.6 225.4 243.5 243.4 269.5 237.3 239.5 249.0
267.0
217.8 247.2 238.6 217.2
237.0
223.5 238.3 243.0 247 !5 .
255.7 269.4 245.3 255.9 265.3 281.1
234.7
264.6 250.1 226.8 250.4
235.8 246.0 257.1 267.5 274.5 283.7 262.8 274.9 276.6 297.9
249.3 281.6 258.1 241.7
257.2
241.8
267.6 261.6 275.8' 293.0 289.3 275.5 282.6 283.3 301.5
254.6
294.0 275.9
250.8 264.2'
228.4
260.9 248.1 264.5 278.5 274.7 273.6
274.9 272.8
291.6 256.0 287.1 277.2
245.0 274.5
248.7 292.3 266.6 286.7 296.3 287.2 304.5 292.8 298.5
315.2
259.9 307.2 290.3 262.4 288.0
Company Sanitized. Does not contain TSCA CBI
-398-
90-Day Oral Gavage S_tudSyuibnchRraotnsic Toxicity
INDIVIDUAL BODY WEIGHTS
DuPont-9478
Female, XV 1 mg/kg/day
655086 655041 655108 655040 655044 655013 655089 655091
655033
655090 655051
655018 655096 655057 655028
254.2 287.3 281.7 283.5 307.4
295.3 318.6 300.7
292.5
326.6 263.5 316.0 294.8 261.6 286.6
256.6 293.9 284.7
295.5 318.7
303.8 325.7 310.7
306.5 329'.3 262.0 326.8 305.0 266.7
292.2
257.5 298.3 289.9
299.9 324.4
306.1 327.4 305.5 309.0
333.4 274.8
332.9 297.7 273.1 301.7
258.6 299.9 284.7 301.5 324.6
302.6 338.3 318.6
317.0
343.5 277.0 337.2 303.0 273.4
307.2
254.3 290.0 284.7
305 i6
329.3 309.3 340.1 315.0
310.2
342.6 283.8
331.1 310.2 270.0 298.0
243.3 276.1 269.3 293.1 317.2
299.4 317.9 302.6
303.6 323.5
290.6
344.4 319.3 276.5 302.4
300.6
349.6 314.3 283.4 307.3
299.0
349.4 320.6 280.2 313.5
Company Sanitized. Does not contain TSCA CBI
-399-
90-Day Oral Gavage StJudSyuibnchRraotnsic Toxicity
'
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Wgeight
Body Weight g
Day 119
Day 126
Female, IV 1 mg/kg/day
Body Weight g
Day 133
Body Weight g
Day 140
Body Weight g
Day 147
Body Weight g
Day 154
Body Weight
g Day 161
Body Weight g
Day 168
Body Weight
g Day 175
655086 655041 655108
655040 655044
655013 655089 655091 655033 655090
655051 655018 655096 . 655057 655028
298.8 353.8 321.6 .282.2
311.9
305.4
361.1 326.2 286.7 316.1
311.5 367.0 332.7 289.2 321.7
306.3 364.0 342.1 288.3 327.1
307.9
373.5 341.5 290.1
325.0
313.2 370.2 354.7 290.1 328.3
318.0 368.6 345.7 292.6
327.3
322.0 367.9 356.3 296.4 337.4
322.3
364.3 365.1
296.2 332.9
Company Sanitized. Does not contain TSCA CBI
400
'90-Day Or_al Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
ET
Day 0
Day 7
J
Female, VI 5 mg/kg/day
Body Weight
g Day 14
Body Weight g
Day 21
Body Weight g
Day 28
Body Weight
g Day 35
Body Weight
g Day 42
Body Weight
g Day 49
Body Weight g
Day 56
655054
655038 655034.
655039 655029 655067 655020 655087 655066
655042 655059 655064 655050 655021 655017
169.6 183.2
170.3
178.4
185.3 204.8 148.6 189.3 196.1
210.9 162.7 190.0 193.3 162.5
188.6
193.7
207.6 192.7
202.9 206.4
225.5 197.9 219.2
212.6
235.6 182.2 205.7 209.3 177.7 198.8
209.4
224.7
211.7
218.8
222.8
244.7
222.6
241.6 241.7
254.1 197.0
226.5 231.5 194.7
214.1
214.5
242.6 223.0
240.8 246.5
267.9
221.8
252.5 260.3 274.8 206.4 252.3 241.9 213.0 226.3
231.6 248.6
231..7
249.8
255.9 274.9 237.4 261.0 274.3 286.7 218.4 269.6 258.5 232.2 232.7
237.2
261.0 243.3
261.8
263.9 285.9 254.5 287.3 289.1 311.4 226.5 286.7 269.6 232.7 249.6
239.9 277.4 257.6
284.6
251.3 288.9 277.7 298.0 298.1 317.8 240.5 302.3 280.1 248.6 261.3
236.1 264.7
248.5
277.5 262.6 286.0 274.5
288.8 286.9 308.3' 239.3 311.5 275.9 254.2
259.9
260.6 280.2 258.6
295.5 279.5 301.7 282.3 296.9 309.6 343.4 246.8 324.5 289.9 265.9 266.6
Company Sanitized. Does not contain TSCA
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
a Day 63
g Day 70 ,
Female, VI 5 mg/kg/day
Body Weight
g Day 77
Body Weight
g Day 84
Body Weight
g. Day 91
Body Weight
g Day 94
Body Weight
g Day 98
Body Weight g
Day 105
Body Weight g
Day 112
655054 655038 655034
655039 655029 655067 655020 655087 655066 655042 655059 655064 655050 655021 655017
261.8 293.6 265.3
296.6 279.3
305.0 300.6 321.7 314.3 347.2 ' 251.2 324.0 295.5 264.4 269.7
261.7 302.4 270.1
313 ;2 288.1
311.8 307.1
319.1 306.9 349.3 . 257.6 329.6 293.9 271.6 278.3
269.8 306.1 275.8 318.4 291.2
314.5 306.2 312.7 318.1 359.2 259.4 339,4 296.8 276.1 281.2
273.1 302.2 271.6
315.3 287.2
311.1 306.9 311.4 324.2 355.6 258.5 338.2 301.5 277.2 278.6
266.6 307.1 277,5 309.4 290.1
311.6 312.6 329.0 326.1 351.9
260.6 333.6 301.8 273.7 285.4
252.3 292.7 259.1
301.3 279.9 291.4 301.6 314.7 308.1 339.8
268.0 346.7 313.1 284.3
287.2
259.2
351.8 308.8 290.2 289.0
263.7
356.7 316.5 296.4 295.3
Company Sanitized. Does not contain TSCA CBI
-402-
)
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight 3
Day 119
Body Weight g
Day 126
Body Weight
g Day 133
Body Weight
g Day 140
Body Weight g
Day 147
Body Weight g
Day 154
Body Weight
g Day 161
Body Weight
g Day 168
Body Weight
g Day 175
VI 5 mg/kg/day
655054
655038 655034
655039 655029 655067
655020 655087
655066 655042 655059 655064 655050 655021 655017
272.6 358.5
317.0 293.6 304.5
273.2 369.3 322.6 297.1 310.2
277.4 382.3 318.4 302.7
318.0
278.1 373.9 323.8 305.6 320.2
274.3 389.2 329.2 306.0
324.0
284.8 405.2 325.3 309.6 331.8
283.3 393.7 327.5 305.9
328.9
287.0 405.7 328.9
312.6 335.4
286.6 408.4 328.5 321.6 334.5
Company Sanitized. Does not contain TSCA
O03
_90-Day Oral Gavage Stu'dSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
3 Day 0
g Day 7
Female, VIII 25 mg/kg/day
Body Weight
g Day 14
Body Weight g
Day 21
Body Weight g
Day 28
Body Weight g
Day 35
Body Weight
g Day 42
Body Weight g
Day 49
Body Weig'
g Day 56
655058 655076 655047
655055 655105 655078 655073
655011 655085
655012 655043 655082 655060 655056 655081
172.7 184.2 161.2
177.3 177.2
208.8 171.7 185.1
200.2
197.9
173.4 196.7 187.1 155.7 189.4
197.1 204.8 177.4 204.5 192.8 235.6 199.8 206.6
223,. 6
226.6 190.0
205.0 203.3 161.9 213.2
220.3 211.7 207.8
225.1
212.1
260.2 226.4
226.3 248.5 245.8
214.5 239.0 220.7 198.7 228.8
233.6 243.5 210.3 240.1 225.6 266.7 236.2 239.5 267.3 259.1 223.6
248.3 243.2 209.2 251.6
245.9 249.5 224.3 246.7 227.4 288.6 25.7
260.9 288.3 264.5
232.9 268.7 261.8 213.6 265.5
265.0 252.8 233.1 261.0 248.1
300.6 260.7
269.8 303.0 278.1
248.4 284.9 266.5 238.3 283.6
272.3 271.1 255.5
273.5 251.2 329.8 276.1 277.4 308.7 286.4
257.5 291.8 289.7
248.2 288.8
251.8 258.7 242.3
254.7 243.7 321.8 266.6 267.9 296.7 279.9
249.7 302.7 297.7 247.4 298.9
272.1 279.2 269.2 275.9 272.7 350.1 287.2 296.8 321.6 307.9
259.7
309.4 316.8 251.9 310.7
Company Sanitized. Does not contain TSCA CBI
-404-
90-Day Oral Gavage Study in Rats Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
gg
Day 63
Day 70
Female, VIII 25 mg/kg/day
Body Weight g
Day 77
Body Weight
g Day 84
Body Weight g
Day 91
Body Weight Day 94
Body Weight g
Day 98
Body Weight g
Day 105
Body Weight g
Day 112
655058 655076 655047
655055 655105
655078 655073 655011 655085 655012
655043 655082 655060 655056 655081
281.5 277.7 264.1 281.4 275.6
340.3 291.4 301.6 324.2
299.9 261.0 311.0 320.5 263.9 322.1
289.4
290.4 273.3 293.8 283.4 368.1 309.2 304.4 331.3
312.3 264.8 319.4 329.5 278.0 328.5
294.3 298.5 278.6 294.1 278.8 370.5 317.3
311.6 340.0 317.8
273.1 321.0 339.1 279.6 343.8
290.1
303.8 274.0 287.4 283.6 364.9 318.0
319.9 347.3 320.6 277.9 327.0 337.5
271.9 345.3
293.1 303.3 264,8
292.5 279.2
361.4 313.9 319.5 339.3 326.1 273.4 325.2 342.6 283.8 341.0
278.2 297.0 264.9
279.5 268.8 351.3 305.3 306.7 317.9 305.6
293.8 335.1 349.5 295.5 340.8
295.9 340.5 349.9 293.2 354.9
292.0
348.0 353.1 296.2 358.9
Company Sanitized. Does not contain TSCA CBI
-405-
)
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
Body Weight Body Weight
g Day 119
g Day 126
Female, VIII 25 mg/kg/day
Body Weight
g Day 133
Body Weight
g Day 140
Body Weight 0
Day 147
Body Weight g
Day 154
Body Weight g
Day 161
Body Weight g
Day 168
Body Weight g
Day 175
655058 655076 655047 655055 655105 655078 655073 655011
655085 655012 655043 655082 655060 655056
655081
303.1 363.4 363.6 307.6
364.9
300.0
377.3 373.3 307.2 373.2
304.7 382.0 370.8 317.0
381.9
300.4 383.3 379.2 316.9
378.2
315.8 395.1 369.5 309.7
383.8
306.2
393.4 388.7 319.5 387.9
302.9
401.0 383.6 318.2 402.3
313.1 410.0 387.4 320.6
410.5
305,6
405.8 393.7 311.8 417.3
Company Sanitized. Does not contain TSCA
O CD
)
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL BODY WEIGHTS
g gBody Weight Body Weight
Day 0
Day 7
Female, X 125 mg/kg/day
gBody weight Day 14
gBody Weight Day 21
gBody Weight Day 28
gBody Weight Day 35
gBody Weight Day 42
gBody Weight Day 49
gBody Weight Day 56
655097
655052 655063 655103 655026 655095 655023
655007 655053
655092 655046 655027 655104 655106 655024 655037
655088
655010 655077 655030
655075 655100 655049 655084 655061
179.5 193.1 165.6 189.9 181.1 209.1 180.1
186.9 203.7 204.9 183.8 202.5 183.9 151.4 192.9 187.2
204.4
198.9 195.4 205.8 207.0
210.3 160.3 168.8 165.4
195.9
211.4 185.0 218.5
211.1
222.4
201.6
207.2 218.3 226.2 203.3 221.5 205.6 161.7 213.5 211.9
223.2
225.3 210.5 229.0 228.1
237.5 177.9 195.1
182.8
216.7 227.1 204.1
239.8 231.4 255.7 227.4
225.8 236.6 248.5 218.6 244.8 228.5 184.0 230.9 241.1
244.6 240.1 229.9 252.5 248.1
260.0 198.9 214.9 209.5
233.9 234.1
211.0
258.5
253.0 275.5 236.2
228.5 258.6 261.7
247.4 259.7 246.2 194.2 254.3 262.4
261.9 257.4
250.0 275.7 275.3 279.1 210.3 236.8
230.7
239.1 249.3 219 ..7
274.5 260.5 283.9 250.9 247.9
277.3 274.1 263.5 270.7
255.3 202.5 267.2 273.0
284.1 266.7 265.9 294.1 287,2 293.0 212.7 241.8 242.5
252.7 258.5 229.9
278.4 281.7 283.6 263.8 262.1 288.1 287.1 280.9 280.9 277.2 210.9
274.2 287.0
285.8 281.1
272.5 301.6 306.2
300.6 222.1 243.1 247.1
267.5 272.2 233.8
282.3 277.6 309.2 271.9
264.3 286.6 291.0 284.1 286.2 280.1 218.4 284.1 297.2
294.2
280.5 271.8 309.5 326.2
314.3 229.1 261.0 262.3
264.0
261.0 223.3 281.2 273.8 302.3 270.4 258.3
273.8 282.3 300.0 290.2 289.7
216.1 295.2 303.9
310.9 294.6
284.3 317.0 340.3 319.5 223.4 267.8 266.3
283.3 279.4 245.3 294.7 288.7 319.4 277.5
277.4 310.6
303.5 313.0 302.9 299-. 9 225.6 307.4 317.3 311.6 298.0 290.6 338.6 355.4 285.3 229.5 267.4
279.0
Company Sanitized. Does not contain TSCA CBI
-407-
90-Day Oral Gavage _S_tu^dSyuibnchRraotnsic Toxicity
INDIVIDUAL BODY
Body Weight Body Weight
gg
Day 63
Day 70
Female, X 125 mg/kg/day
Body Weight g
Day 77
Body Weight g
Day 84
Body Weight g
Day 91
655097 655052 655063
655103 655026
655095 655023
655007 655053 655092 655046 655027
655104 655.106 655024 655037
655088 655010
655077 655030 655075 655100
655049 655084 655061
290.0 280.3 246.8
302.5 294.7 334.2 ' 285.6
288.3 315.0 304.4 324.0 303.3 301.6 227.5 304.1 322.6
,315.2 301.7
292.4 334.7 363.5 318.9
235.0 265.1 275.7
294.2 288.4 250.7
303.6 307.5 332.3 292.3 286.2 313.8 296 .'5 324.2 306.7
310.4 234.1 314.7 327.1
310.3 302.3 285.1 329.2 359.2 324.9 240.4 278.4 288.3
301.8
278.6 251.7
305.8 296.8 336.6 292.1
290.3 317.9
308.0 332.4 309.5 314.0 239.8 323.3 335.2 311.1
297.5 291.2 331.9
359.8 333.1 242.0 284.7 290.5
315.9
293.4 265.8
314.5 300.9 336.1 298.1
307.2 332.0 315.6 343.5 317.8 329.6 248.3 323.8
342.3 315.0 306.1 291.8
,352.0 371.3 341.4 241.0 293.2
285.5
309.7
289.8 272.2 310.i
298.8
324.6 304.2 310.1 333.9 310.7 350.9 318.6 326.3 251.0 319.5
349.9 314.7
318.0 299.2 343.6 360.3 332.1 241.5 280.7 283.8
Company Sanitized. Does not contain TSCA CBI
-408-
)
DuPont-9478
WEIGHTS
g g g gBody Weight Body Weight Body Weight Body weight
Day 94
Day 98
Day 105
Day 112
294.8 277.8 251.5 294.3 283.1
317.1 282.7
283.0 305.9 299.4
357.2 314.6 335.7 263.2 333.0 349.3 322.2 297.1
304.4 364.8 366.4 335.7 246.8 286.2 288.1
354.4 304.1 332.4 264.1 340.7
: 348.7 328.0 302.3 305.3 358.0 361.9 337.8 244.2 291.6 294.2
371.1
314.9 340.0 256.5 340.4 351.0
294.0 300.5 311.1
364.5 374.6 341.1
245.6 292.6 288.9
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
DuPont-9478
INDIVIDUAL BODY WEIGHTS
gBody Weight Body Weight 9
Day 119
Day 126
Female, X 125 mg/kg/day
9Body weight Day 133
gBody Weight Day 140
Body Weight g
Day 147
Body Weight g
Day 154
gBody Weight Day 161
gBody Weight Day 168
gBody Weight Day 175
655097
655052 655063 655103 655026 655095 655023 655007 655053 655092
655046 655027 655104 655106 655024 655037
655089 655010 655077 655030 655075 655100 655049
655084 655061
375.6 322.7 334.0 262.5 342.9 350.9 332.5 301.6 323.7 376.1 384.1
342.4 246.5
289.5 289.1
389.0 336.4 354.6 273.7 355.2 372.5 358.3
311.3 332.0 406.1 402.6 358.0 252.7
294.5 304.9
388.9 336.7 347.7 282.5 355.1 384.5 373.6 314.6
324.8 413.5 410.2
359.8 253.9 304.1 308.6
397.5 332.8 356.8 281.3 351.8 379.0
368.1 312.2 319.2 420.4 409.1
362.6 253.0 305.7
300.5
398.5 335.3 348.1 288.1 357.5 384.0 382.1
318.0 332.9 438.7
422.3 370.6 259.1
304.8 302.1
400.2 340.0 380.4 286.5 357.7 395.5
381.9 324.2 338.2 449.3
427.5 364.7 263.2 311.7 305.7
405.5 334.7
384.9 283.6 353.2 395.8 386.5 313.1
333.9 444.3
429.5 365.1 258.5
313.8 306.0
415.1 340.3 381.0 290.9 365.2 402.3
395.3 314.8 331.2 467.0
445.4 369.5 261.1 314.2 313.3
418.3 346.2 372.1 296.0 364.0 403.2 404.3 323.1
339.1 479.5
449.4 376.6 262.2 312.2 308.4
Company Sanitized. Does not contain TSCA CBI
-409-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StJuSduybicnhRroatnsic Toxicity
Body Weight Body Weight
g Day 182
g Day 183
Female, X 125 mg/kg/day
655097 655052 655063
655103 655026
655095 655023 655007
655053 655092
655046 , 655027 655104 655106 655024 655037 655088 655010 655077
655030 655075 655100 655049 655084
655061
416.9 391.8 327.7 347.2 480.0 456.5 370.6
266.5 320.3
309.7
394.4 374.8 306.3 326.6 455.3 432.2 358.5 249.7 302.1
289.3
INDIVIDUAL BODY WEIGHTS
-410-
/)
DuPont-9478
Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
APPENDIX D INDIVIDUAL FOOD CONSUMPTION
-411 -
Company Sanitized. Does not contain TSCA CB!
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 7
Day 14
Day 21
Male, I 0 mg/kg/day
Food Cons. Food C ons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day g/anm/day
Day 28
Day 35
Day 42
Day 49
Food Cons.
g/anm/day Day 56
Food Cons. Food Cons
g/anm/day g/anm/day
Day 63
Day 70
654928 654993 654929 654972 654950 654953 654925 654987 654903
654966 654997 654971
654939 654919 654994 654949
654992 654909 654924 654943 654915 654927
654956 654910
654936
22.6
23.2 28.5 25.7 27.7 34.9 28.4 30.0 28.6 27.6 29.0 22.9
30.5 25.3
21.9
25.1
28.0 23.8 25.3 26.0
28.3 30.3 24.6
28.9 26.9
14.2
24.5 28.2 25.6 28.5 35.8 30.4 29.7 30.0 28'.7 29.7
25.4 33.2 26.2 25.3
25.5 30.3 27.5 27.1
28.3 29.5 31.9 26.9
31.4 ' 34.0
25.7 25.8 28.5 26.9 30.3 35.9 30.6 30.4 33.3 28.6 29.6
30.0 34.1 28.0 24.3 26.6
30.3 27,5 28.3 28.2
31.0 37.5. 27.7
34.0 31.9
28.1 26.8 30.3 26.9 31.5 38.6 30.1 26.4 36.0
31.8 31.2 31.7
34.5 29.0 25.2 27.8
30.6 26.9 30.1 29.9
33.4 34.5
27.5
30.8 32.7
29.5
27.4 30.3 26.4 32.2 40.7 30.3 29.0 34.7
7.8
31.2 33.6 36.4 28.1 24.9 28.2
31.1 27.7 29.8 30.6
37.2 34.6 30.5 34.2
33,3
28.6 26.1 28.0 26.1
32.8 38.5 29.2 29.6 34.4 10.4 29.9
31.5 38.6 29.3 25.4 27.2
29.3 27.9 28.3
28.9 32.6 31.6 28.3
32.5 33.6
25.7 22.9 25.5 23.6
27.5 33.2 27.9 26.9 30.6 25.8 30.1 32.0 37.8 29.8 24.1 28.7
30.8 26.0 27.5 29.9
32.8 31.6 27.5 34.9
27.8
28.8
26.5 29.7 26.1 29.9 36.2 30.7 28.9 31.7 26.2
30.4 30.9 35.8 28.9 23.0 29.5
31.4 25.0 26.1
27.1 31.1 32.0 27.9 33.9
28.6
28.8 25.8 28.6 25.0 29.1 36.3 28.8 28.8 30.8 16.3 27.2 29.1 31.4 28.1
20.9 30.2
29.6
26.3 26.0 28.1
31.0 ' 30.2 27.7
33.9 30.2
28.0 24.5 28.1 25.0 29.4
3 7 .8
26.5 28.2 34.1 24.6
30.2 32.2 33.9 29.0 25.3 29.5
29.8 27.0 27.2
28.6
29.6 32.7 27.1 32.1
30.5
Company Sanitized. Does not contain TSCA CBI
-412-
0 |9K0-aDfaHy HOrHal lGHavBag^eSSituibdyc hinrRoantsic Toxicity
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Male, I 0 mg/kg/day
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 98
Day 105
Day 112
Day 119
Day 126
Day 133
Day 140
654928
654993 654929
654972 654950 654953 654925
654987 654903 654966
654997 654971 654939 654919
654994 654949 654992 654909
654924 654943 . 654915 654927
654956 654910 654936
27.5 24.8 28.7
26.0
22.8
36.1 28.5
29.8 31.9 27.1
30.8
30.6 34.3 29.2
23.3 27.6 30.5 26.9 26.8 28.2
30.3 32.6 26.9 29.9 29.5
28.0 23.7 28.6
24.7 31.8
34.8 28.0 28.2 33.1 28.7 28.7 .
29.3 33.7 25.7
23.1
27.8 29.0 26.2
24.4 26.8 29.1 28.5 25.5 29.4 30.4
28.1
23.6 28.2 26.5
30.6
18.9 28.1
28.0 32.3 28.2 30.1
30.7 34.5 27.4
24.2 27.9 29.5 25.8
25.8 24.9 29.2 28.6 24.6 29.4
30.6
25.1 28.1 27.0 24.5 26.2 27.5 29.0 29.5 25.1 29.9
23.7
26.5 29.6 27.6 27.9
28.5 31.4 30.6 27.4 30.6
24.9 27.7 30.8 28.4
28.6 28.5 30.8
31.5 26.8 30.0
23.2 27.0 29.9 26.7 28.5 23.1 30.4
31.0 26.1 30.1
24.7
27.3 31.0 24.9
26.6 27.1 29.7
30.0 25.8 29.7
25.5 27.3 30.0 25.5 26.7 29.1
31.6 31.6 26.2 27.5
22.4 26.9 29.2 26.2
25-9 28.4
29.9 31.7 28.5 31.6
Company Sanitized. Does not contain TSCA CBI
-413-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StuJdSyuibnchRraotnsic Toxicity
INDIVIDUAL FOOD CONSUMPTION
Food Cons. Food Cons,
g/anm/day g/anm/day
Day 147
Day 154
Male, X 0 rag/kg/day
Food Cons. Food Cons,
g/anm/day g/anm/day
Day 161
Day 168
Food Cons, g/anm/day
Day 175
Food Cons, g/anm/day
Day 182
654928
654993 654929 654972 654950 654953 654925
654987 654903 654966 654997 654971 654939 654919 654994 654949 654992 654909
654924 654943
654915 654927
654956 654910
654936
23.2 26.8 28.8
'2 1 . 8
25.5
25.3 30.0
30.6 26.6 29.5
23.6 26.8 28.4 24.9 25.3
28.5
30.9 30.4 26.8 29.3
24.2 26.9 28.6 26.3 28.0
28.3 32.1 30.3 27.3 30.6
25.5 28.3 30.7 25.6 28.6
30.4
31.9 29.1 25.0 29.7
24.8 26.6 30.4 24.5
29.6 26.5
33.8 29.9 25.7 30.4
25.0
26.6 27.7 26.3
27.6 26.8 32.4
29.9 26.6 29.9
-414-
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
)
DuPont-9478
Food Cons. g/anm/day
Day 7
Food Cons.
g/anm/day
Day 14
Male, III 1 mg/kg/day
Food Cons.
g/anm/day
Day 21
INDIVIDUAL FOOD CONSUMPTION
Food Cons.
g/anm/day
Day 28
Food Cons.
g/anm/day
Day 35
Food Cons.
g/anm/day
Day 42
Food Cons g/anm/day
Day 49
654913 654947 654995 654938 654941
654946 654960
654908 654984 654932 654948 654904 654954
654945 654988
26.4 27.2 27.2 28.9
30.8 33.7 30.0
29.2 30.8
29.9 30.6 26.6
28.2 22.7 28.0
30.2 29.7 29.5 31.6 32.0
35.0 29.4
30.6 30.9
30.fe
31.0 27.3 29.0 25.7 29.3
30.2 29.8 30.5 32.2 34.2
33.9 29.3 35.4 29.7 31.7 32.1 28.2 31.7 28.7 31.0
29.2 29.2 27.1 30.4 32.6 29.7 26.7
31.3 30.8 30.4
32.3 28.3 31.4
26.9 30.2
30.8 28.0 29.1 25.1 34.2
31.9 28.3 31.9 31.6
30.2 32.7 30.3 33.1
28.1 30.6
29.8 27.0 28.9 30.4 30.4
32.4 27.7 32.8 31.5
29.8 30.4 29.7
32.0 28.2 29.3
25.3 24.4 25,2 27.0 25.6
28.6 24.1 27.0 25.3
27.5 30.2 28.4
31.1 27.6 29.8
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 56
Day 63
Food Cons
g/anm/day Day 70
29.4 27.8 26.9 30.1 28.9
30.5 29.9 30.4
30.3 29.3 29.2
27.0 32.0 28.3 28.7
29.2 26.7 27.9 30.7 28.9
29.7 29.0 ,30.0 32.2
30.4 30.2 25.3 31.0 26.2 28.5
29.8 27,4 29.6 31.9 30.9
33.1 27.0 28.8 33.4
30.6 30.3 27.0 31.6 24.1 28.9
Company Sanitized. Does not contain TSCA CBi
-415-
90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity
Food Cons. g /aran/day
Day 77
Food Cons. Food Cons
g/anm/day g/amn/day
Day 84
Day 91
Male, III 1 mg/kg/day
654913 654947
654995 654938 654941
654946 654960 654908
654984 654932 654948 654904 654954 654945 654988
29.2 26.9 27. r
30.7 31.3 30.7
28.2 30.0 32.4
29.9 37.7 30.4 31.8 25.3 28.5
27.1
27.1 26.2 28.7
26.8 28.3 27.2 28.6 30.3 29.1 29.9 26.9 28.8 25.3 29.6
30.0 27.0 28.1 31.7
27.3 28.3 28.1 27.4
29.2 30.6 31.4 28.0 31.7 25.1 30.0
)
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-416-
90-Day Oral Gavag_e SJtuSdyubicnhRroantsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons,
g/anm/day Day 7
Food C ons. Food Cons,
g/anm/day g/anm/day
Day 14
Day 21
Male, V 5 mg/kg/day
Food Cons. Food Cons
g/anm/day g/anm/day
Day 28
Day 35
Food Cons, g/anm/day
Day 42
Food Cons,
g/anm/day Day 49
Food Cons, g/anm/day
Day 56
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 63
Day 70
655005. 654907
654980 654959 654961 654916 654911 654917 654998 654970 654926 654918 654981 654969 654967
26.5 25.5 28.4 31.3
29.5 30.5 30.7 28.4 29.6 21.4 27.3 27.4 22.7
21.1
27.4
28.9
28.8 30.6 34.O' 33.7 30.1
35.4
31.3 31.1 23.2 28.7 30.6 25.6
22.6
29.9
30.6
27.6 32.4 35.0
36.9 31.3 36.7
30.5 31.8 24.7 32.1 31.6 27.4
22.6
29.3
31.7 27.9
33.2 36.1
'36.6 30.6 37.7
29.5 32.9 26.1 33.4 32.8 28.1
23.7
29.6
30.7
27.3 35.0 35.1
38.3 30.7 36.9
31.5 33.6 25.2 35.8 33.8 27.9 25.7
30.3
30.9
27.9 34.8 . 35.3 ' 34.4 30.5
37.5 33.8 32.1 23.3 32.3 31.5 25.9 24.2 29.0
28.5
23.5 30.2 31.9
30.4 27.4 31.2 30.1 30.1
24.5 33.8 32.2 25.8 24.5 25.2
31.2
28.0 33.9 32.1
33.2 30.1 34.7
30.6 31.5 23.6 32.2 32.6 24.6 25.3 29.2
32.3
27.0 324 33.7
34.0 28.0 34.0
32.9 32.1 23.8 32.2 32.0 24.5 24.0 28.6
31.0
27.4 31.1 31.8 35.3 28.3 32.3 30.0 32.4 26.3 33.8 32.1 27.1 26.1
28.6
Company Sanitized. Does not contain TSCA CBI
-417-
90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity
Food Cons.
g/anm/day Day 77
Food Cons. g/anm/day
Day 84
Food Cons
g/anm/day Day 91
Male, V 5 mg/kg/day
655005 654907
654980 654959 654961
654916 654911 654917 654998 654970
654926 654918 654981 654969
654967
32.0
25.3 33.4 32.0
33.5 29.2 32.7 30.7 32.7
27.2 30.5 30.8 25.9 26.7 28.4
30.3
26.6 31.3 31.0
32.0 31.4 34.2 30.3 32.1 26.1 28.9 31.4 26.4 25.8 27.4
27.4 26.6
32.9 33.3 30.2 30.4 32.0 31.0 25.4 24.6 33.6 28.0 27.2 25.4 26.0
)
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
-418-
90-Day Oral Gavage StjudSyuibnchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food C ons. Food Cons,
g/anm/day g/anm/day
Day 7
Day 14
Male, VII 25 mg/kg/day
Food Cons. Food C o n s . Food Cons. Food C ons. Food Cons. Food Cons. Food Cons-,
g/anm/day Day 21
g/anm/day Day 28
g/anm/day Day 35
g/anm/day Day 42
g/anm/day Day 49
g/anm/day Day 56
g/anm/day Day 63
Food Cons. g/anm/day
Day 70
655001
654975 654922 654940 654930 654958 654952 654923 654989
655006
654920 654912 654934 654964
654933
31 .6 26..2
25..5
28,.7
28,.2
26 .4
27 .9
26 .9
30..2
31..7
24..8
23 .4
27 .8
29 .7
30 .2
34..0
29..5
28..1
30..3
32..6
27,.7
31..1
31..9
33.,.7
31,.3
27..7
24,.4
27..8 29,.8
33 .3
38 .6 30..8 30..0 31..2
33..7
2.8..0 31..1
32 .4
31..9
31,.2
29,.5
24..1 28 .6 30 .6 35 .8
40..9
28..4
28..2
29..7
34..8 27..6 30..1
32..9
32..1 30..6
29..7
24..5
26 .8
30..9
36,.2
41.,3
28.,3
30.2 32,,2 36..8 30..0
32..7
31,.4
32..2
31..5
30.,1 24..8
29..5
33..4
38..6
37..6
28.,4
30..5
30..9
35..8 28..2 32..0
30..5
32..0 32,. 1 30..1 24,.8 27..6 34..0 38.. 1
33..5
26..0
27..4
27..5
31..7
25..6 28..2
26..5
27..6
26..9
29..2 24..8 29..2 33,.6
38..5
37.,5
28. 8 34..1 28. 8
31.,9
27..6 31..6
29.;7
33.,1 31..1
30.,9
26..3
30..1 32.,8
37,.9
37..9
30.,5
33 ..2 30.,6 34..2
27..5
31..2 28..8
32,.7
29,.9
30..8
26..7
29..3 34,.3
36,.7
37.,4
27 .,6
30.,5
31..1 33 ..8
27.,5
29.,2
26..5
31..0
29..7
29..2 26..1 28,.1 30..8
34,.4
Company Sanitized. Does not contain TSCA CBI
-419-
p M90M-DayHOBraHl GHaHvaBgeRSStuudbycihn rRoantsic Toxicity
Food Cons. Food Cons. Food Cons.
g /aran/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Male, VII 25 mg/kg/day
655001 654975 654922
654940 654930 654958
654952
654923 654989
655006
654920 654912 654934 654964 654933
36.4. 27.7 32.1
30.4 32.2 27.0
32.4 27.9
31.3 27.7 29.2
27.7 27.8 30.9 34.3
32.7 27.0 29.7
28.4 28.3 26.9
31.0 29.1 30,.9
28.5
28.9 24.7 29.1 29.6 33.3
35.3 30.5 30.2
28.7 30.5 27.6
30.3 27.2 32.3
27.5 29.7 24.3 31.5 34.2
34.5
)
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-420-
90-Day Oral_G__a_v_a_g_e_SStuubdcyhirnonRicatTs oxicity
)
DuPont-9478
Fg o/ oadnmC/odnasy
Day 7
Food Cons. Food Cons
g/anm/day g/anm/day
Day 14
Day 21
Male, IX 125 mg/kg/day
654983 654965 654979
654986 655003 654921 654996 654951 654955 654914
654937
654962 654982 654931 654906 654985 654978 654974
654990 654976 654957 654973 654977
654942 654991
28.5
23.7 24.8
28.5 26.2 29.5
28.0 27.7 30.4 27.4
27.0
26.4 25.4 26.5 28.9 22.3 23.2 25.7
26.0 23.6 27.8 28.5
20.8
27.9 30.1
30.9
26.9 26.5 29.3 29.5 31.7 29.0 28.8 33.1 29.1
29.7 30.4 28.0 29.8 31.7 24.1 24.8 29.0 27.0 28.9
30.4 28.8
25.5 30.1 33,2
31.4 28.1
26.3 31.8 28.6 31.7 28.6 30.2 37.1
27.9
31.5
33.7 30.4 32.6 34.5 26.2 26.0 29.1
27.1 29.6 30.2 28.3
25.0 30.4 34.6
INDIVIDUAL FOOD CONSUMPTION
Food Cons.
g/anm/day Day 28
Food Cons,
g/anm/day Day 35
Food Cons. Food Cons. Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day g/anm/day g/anm/day
Day 42
Day 49
Day 56
Day 63
Day 70
31.2
27.5 25.7 31.9
27.9 31.6 27.0 30.8 34.6 28.3
30.3 32.2 29.5 31.3 32.2 25.0 25.0 29.2
27.6 26.7
28.7 28.0
23.5 28.2 34.6
33.4 27.7
27.9 33.5 27.6
34.1 29.9 31.6 33.7
30.5
31.3
33.6 31.6 32.0
36.9 23.9 25.2 29.8
28.0 27.7 29.7
29.9 26.2 29.2
35.4
33.7
27.5 27.4
33.4 28.6 28.7 26.5 31.3 33.0 29.4
31.2
32.0 30.7 32.6 36.7 26.9 25.1 29.4
26.9 27.0 28.7 27.6
24.5 29.9
35.6
29.5 24.6 26.1 28.5 26.9 28.1 24.9
28.5 29.2 27.1
30.8
31.7 31.4 32.2 38.0 26.1 24.1 28.6
27.7 26.8 28.9
25.7 23.9
29.5
35.6
30.0 23.6
27.3 32.9 29.3 32.7
29.6 29.6 31.2 27.9 29.2
32.2 31.0 30.3 35.5 25.3 26.1 27.5
26.2 26.3 28.2 26.3 23.8 28.5 36.3
, 31.5 27.4
27.624.7 27.8 31.9
21.1
29.3 31.0 28.8
30.8 29.8 23.7 28.1 34.9 25.6 24.5 28.4
27.8 19.3 27.3 13.9
24.3 32.1
28.9
30.2 25.7
28.1 17.4 25.1
29.8 25.9 27.4 31.6 27.2
29.6
31.2 27.7 17.7
35.8 22.5 25.9 24.8 27.6 26.8 25.7 26.7
17.9 27.9 28.8
Company Sanitized. Does not contain TSCA CBI
421
f^B90M-DBayMOBraBl GBaBvaBgeBSjStuudbycinhrRoantsic Toxicity
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. g/anm/day
Day 77
Food Cons. g/anm/day
Day 84
Food Cons. g/anm/day
Day 91
Food Cons. g/anm/day
D a y 98
Food Cons. g/anm/day
Day 105
Food Cons. g/anm/day
Day 112
Food Cons.
g/anm/day Day 119
Food Cons. g/anm/day
Day 126
Food Cons. g/anm/day
Day 133
Food Cons g/anm/day
Day 140
Male, IX 125 mg/kg/day
-
654983 654965
654979 654986 655003 654921 654996 654951 654955 654914
654937 654962 654982 654931
654906 654985 654978 654974 654990
654976 654957
654973 654977 654942 654991
29.8
19.5 26.8
22.6
26.3 31.6 25.9 27.8 26.4
30.1 29.7 30.4
20.8 11.6
33.7
12.0
25.6 9.5
27.4 25.1 27.4
29.0 24.2 28.5 29.6
26.0
31.9 26.1
33.3 26.6 28.4 29.9 24.9
12.2
29.5 24.6 25.4 27.3 31.8 26.3 17.1
25.4 23.7
29.8 29.9
27.3 27.4 23.5 24.6
32.0
30.2
30.6
27.8 36.5 28.1 30.4 30.1 28.8 35.2 30.6 28.8 30.3 31.7 28.1
35.6 23.9 25.9 30.7 29.7
29.3 26.2
26.0 21.5 25.7
32.7
18.6
25.1 28.2
25.6 25.4
25.5 '26.2
22.0
25.5 33.3
19.8 25.2 27.5 26.2 25.4
26.2 26.2 23.4 25.1
33.9
22.5
26.3 27.8 27.4
25.1 26.7 25.4
23.1 24.6 31.6
22.5 24.3
26.0
29.0
26.6
27.4
27.2
22.8
25.8
33.8
14.9 25.7 28.2 29.0
26.6 27.2 27.2 23.4 27.0 32.6
22.6
25.0 29.2
30.3 25.3
28.3 27.5 22.9 26.5
33.7
24.5 25.7
30.2 29.2
26.9 31.3 29.7 23.0 26.4 33.8
Company Sanitized. Does not contain TSCA CBI
-422-
Company Sanitized. Does not contain TSCA CBI
^ f9lH0-DHaByHOrHalBGHavHag^efSt^tuudbycihn rRoantsic Toxicity
INDIVIDUAL POOD CONSUMPTION
Food Cons. .Food Cons,
g/anm/day g/anm/day
Day 147
Day 154
Male, IX 125 mg/kg/day
Food Cons, g/amn/day
Day 161
Food Cons, g/anm/day
Day 168
Food Cons, g/anm/day
Day 175
Food Cons, g/anm/day
Day 182
654983
654965 654979 654986 655003 654921 654996 654951 654955 654914
654937 654962
654982 654931
654906 654985 654978 654974
654990 654976 654957
654973 654977 654942 654991
19.0
24.1 28.7
30.0 26.1
28.9 28.0
21.8
25.6
31.7
28.1 24.8 27.6
29.5 25.8 26.4 27.2 21.7 26.8 30.4
23.5
24.5 28.0
30.1
24.5 25.9
25.7
21.8
26.2 31.1
25.1 24.5 31.1 30.5 26.4 .26.6 28.2
23.0 27.6 32.2
22.4
23.5 29.0 27.5 25.7 26.5 25.8 23.3 27.0 33.0
21.0
24.8 30.2 28.1 25.8 28.2 26.6
22.8
28.5
33.8
-423-
)
DuPont-9478
"X 90-Day Oral Gavage Study in Rats Toxicity
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. cj/anm/day
Day 7
Food C ons. Food Cons.
g/anm/day g/anm/day
Day 14
Day 21
Female, II 0 mg/kg/day
Food Cons. g/anm/day
Day 28
Food Cons. g/anm/day
Day 35
Food Cons. g/anm/day
Day 42
Food Cons. g/anm/day
Day 49
Food Cons. g/anm/day
Day 56
Food Cons. Food. Cons
g/anm/day g/anm/day
Day 63
Day 70
655031 655107
655098 655016 655079
655036 655025
655099 655032 655083 655093 655045 655065 655074
655035 655009
655068 655019 655062
655109 655101. 655072
655015 655071 655022
16.7 17.6 18.2 19.2 16.1 20.4
19.5 23.1
20.1 .
20.3 14.9
18.8 20.5 19.7 19.6
19.9 20.7
21.1 20.8
20.4
22.0
21.4 18.2 18.1 18.4
19.3
16.8 18.0 18.2
15.0
19.7
20.0
23.7
19.-8 19.4
15.2 19.5
20.8 20.1 21.0
20.9
22.2 21.2 20.1
20.5
21.6 21.1
18.4
14.8 19.3
21.5 16.6 19.1 18.9 17.1
22.2
21.9
22.8 22.1 20.8
17.2 21.7 22.4
22.1
22.5 23.6 23.0 24.1
21.8 21.2
23.0 22.5 17.7
20.8
20.8
21.4
16.3
16.0
18.7
17.9
19.6
19.3
16.8
16.9
21.4 ' 20.9
2 1 . 1 21.4
22.6
23.7
21.4
21.7
20.3
20.4
15.7
16.9
20.3
21.4
22.8
24.6
21.1 22.1
20.2
21.3
22.3
22.2
20.5
22.5
23.1
23.4
19.8
22.8
20.8
20.4
. 23.5
25.1
21.7
21.6
17.6
19.8
20.0 20.0
22.8
17.7 18.6
20.8
17.6
22.5 22.5
23.9 23.5
21.1
17.4 20.5 23.8 21.9 22.3 23.4
20.2
23.5 22.5
20.1
24.0
22.0
18.7
19.5
19.1 14.4 15.3 18.4
16 ;6 20.1
19.8
22.2 21.2
19.9 15.7
20.2
23.1
20.8 21.6
24.1 19.7 21.4 20.9 18.9
23.9
20.6
15.8
18.6
22.4 17.9 18.8
21.2
18.3
21.8
21.4 23.0 23.5 23.4 17.9 21.9
27.0 19.3 19.9 23.8
21.6
22.4
21.8
20.5 23.1
20.2
18.6
19.8
22.2
17.3 17.3
22.1
17.5 21.3
22.0 21.6 2 1 .5 20.8
17.2
21.8
26.2
21.1
21.7 24.9
20.0 2 .2 22.0
19.6 23.0 20.4 18.9
19.2
22.0 17. 7
17.8
20.6
17.4 19.6
2 2 .3
22.3
21.8 22.2
17 .5 19.5 24.0
21.1 2 1 .5
23.0 20.4
21.0 22.2
18.7 22.9 20.5 17.1
18.7
Company Sanitized. Does not contain TSCA CB1
-424-
90-Day Oral Gavage Stu|SdyubinchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Female, IX 0 mg/kg/day
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 98
Day 105
Day 112
Food Cons.
g/anm/day Day 119
Food Cons. g/anm/day
Day 126
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 133
Day 140
655031 655107
655098 655016 655079
655036 655025
655099 655032
655083 655093 655045 655065 655074 655035 655009
655068 655019 655062 655109 655101 655072 655015 655071 655022
21.5 16.6 17.0 19.8 18.1 21.4
22.0 21.8
22.3
22.1
18.0 20.3 23.8 21.7 . 23.3 24.0 19.7
20.2
24.0 18.6' 21.9 20.7 18.0
20.2
20.2
16.5 17.3 20.9 17.0 22.3
21.2 22.0
18.0
2 2.T
17.4 20.7 25.9
20.1
21.5 24.1
20.0
19.5 24.3 19.6 24.8 19.5 17.3
18.3
18.1 16.4 15.9 19.7 16.9 20.5 21.7 17.9 21.7 21.4 16.9
20.1
25.0 21.7 19.8 22.9 17.5
20.2 21.6
18.0 22.3 19.0 18.4
18.2
18.3
20.9
19.0 19.6
22.0
16.2
22.3
22.0
15.6
22.6
23.5
21.0 20.1
26.1
19.0
22.6
20.3
14.8
20.6
25.1
23.3 20.4 25.1
20.1
22.3
21.0
19.2
20.4
20.2
19.2 19.4
25.6
18.8
20.8 20.8 20.2
21.9
21.3
21.2
21.7
27.3
18.8
23.0
23.0
20.2
21.2 22.6 .2 1 . 8 21.8
24.1
17.3
26.0
20.6
21.3
20.9
24.7 22.4 24.2 24.9 19.2
23.3
21.0
21.4
Company Sanitized. Does not contain TSCA CBI
-425-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudbyuibncRhraotnsic Toxicity
INDIVIDUAL FOOD CONSUMPTION
Food Cons.
g/anm/day Day 147
Food Cons. Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day g/anm/day
Day 154
Day 161
Day 168
Day 175
Female, II 0 mg/kg/day
Food Cons
g/anm/day 'Day 182
655031 655107
655098
655016 655079
655036
655025 655099
655032 655083 655093 655045 655065 655074
655035 655009 655068 655019 655062 655109 655101 655072
.655015 655071
655022
7.3
22.2 21.6 22.1
23.8 18.5
22.4
21.0
20.5
15.1 20.5 19.7 23.9 23.9 18.4
22.4 21.7
21.3
16.2
21.2 2 1 .4
21.7
25.8 17.1
22.3
20.5
18.8
22.0
22.3
22.1
24.4
26.1
18.1
22.6 20.2
21.5
21.4 21.4 23.0 23.8 25.0 18.9
24.4
22.6 21.1
24.3
20.2 21.6
24.2
25.0 18.1
23.9
23.6
20.6
-426-
)
DuPont-9478
)9_0_-D__a_y_O__r_a_l_G_avage Stu|dSyubinchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 7
Day 14
Day 21
Female, IV 1 mg/kg/day
Food Cons. Food C ons.
g/anm/day g/anm/day
Day 28
Day 35
Food Cons. Food Cons. Food Cons
g/anm/day 'g/anm/day g/anm/day
' Day 42
Day 49
Day 56
655086 655041 655108' 655040 655044 655013 655089
655091 655033 655090 655051 655018 655096 655057 655028
18.0 18.1
18.8
22.0
20.3 22.4
19.8
20.4 ' 19.1
23.2 18.1
22,5 18.9
17,.3 19.1
18.2 18.9 19.2
21.9
21.1
21.3
20.2
20.3 19.1
20.'8
16.5
20.4 19.1 17.9
19.3
18.8 20.9 20.5 23.9 22.9 23.0
22.4 19.6
20.6
23.9 17.9
22.1 20.0
18.6 19.9
17.3 19.0 20.4
20.6
21.7
19.8 20.7
22.2 20.1
22.7 17.6
22.7
18.6 18.1
19.5
18a.1
19.3 23.5 21.4 20.4
22.2 22.8
20.5 23.0 18.7 23.3 19.1 19.9 19.6
18.7 23.9
19.1
23.1
22.1
19.8
22.3
22.2 21.8 22.2
19.3
22.4
20.8 20.1 20.8
16.0 19.516.9
18.9 18.8 17.6
21.0 20.1
18.5 20.7
18.0 20.5 19.1 18.6
18.8
19.4 24.6
20.5
21.8 20.6
19.8
24.4
23.4
21.2
23.6 < 17.5
25.5 20.5
20.6
19.5
Food, Cons. Food Cons
g/anm/day g/anm/day
Day 63
Day 70
18.5
20.8
20.3 21.7
22.1
19.3 24.2
22.6
20.3 23.0 17.4
24.7 20.9
19.0
19.3
18.9 21.4
19.5
22.2
21.3
19.6 23.7
21.9
21.2
22.4 13,2
26.1
20.1
18.8
19.5
Company Sanitized. Does not contain TSCA CBI
aInaccurate data; food consumption value not calculated.
90-Day Oral Gavage SftfugdSyubinchRraotnsic Toxicity
Food Cons. Food Cons. Food Cons
g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Female, IV 1 mg/kg/day
655086 655041
655108 655040 655044
655013 655089 655091 655033 655090 655051 655018 655096 655057
655028
18.1
20.2 20.2 22.0 21.2
19.9 23.5
20.6
18.9
23.9 18.3 24.3 18.4 18.7
21.0
17.3
19.0
18.5
21.8
19.2
20.1
23.1
21.3
20.8
22.-5 17.6
24.3
20.1
18.4
19.9
17.1
17.0
18.6
22.5
20.1
19.0 20.5
21.0 20.1 20.2
19.1
22.2
19.9 19.0
19.3
)
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
- 428 -
90-D_a_y_O__r_a_l _O_a_v_a_g_e_StudSyuibncRhraotnsic Toxicity
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. Food Cons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 7
Day 14
Day 21
Female, VI 5 mg/kg/day
Food Cons. Food cons.
g/anm/day g/anm/day
Day 28
Day 35
Food Cons. g/anm/day Day 42
Food Cons.
g/anm/day Day 49
Food Cons. g/anm/day
Day 56
Food Cons. Food Cons
g/anm/day g/anm/day
Day 63
Day 70
655054
655038 655034 655039 655029 655067 655020
655087 655066 655042
655059 655064 655050 655021
655017
19.6
21.1
19.5 19.6 20.3
20.1
19.1
21.0 22.6
23.5
17.3 17.9 19.7 16.6
19.0
19.5
20.0
18.0 19.3 19.5 19.5
20.1 21.6
23.7 23 .'1
18.0 18.4 19.4 15.9 18.2
20.0 21.8 20.2 21.0
22.5
21.6
18.4
21.5 25.5 25.5
18.8 21.5 21.3 19.0
19.6
20.5
21.0
19.8
20.9
20.6
21.3
20.2 22.2
24.3
24.6
19.1
21.3
21.0
19.3
18.7
19.8
20.8 20.6 21.0 21.1 20.6 22.8
23.9 26.0
25.3
19.3
22.6
20.9 17.7
20.6
18.9
22.4
20.9 23.8 16.0 21.4 22.9
20.9 24.1 24.1
19.2
22.8 21.2
18.9 20.4
18.7
18.7 18.5 20.5 18.9 18.9 21.7
20.3 21.4
25.3 17.9 23.5
20.1
19.1
19.4
20.8
22.7
20.4
22.0 20.8
21.3
25.1
23.2 23.3
25.8
19.2 24.1
22.1
18.9
21.8
20.0
23.0
20.8
23.7
18.5
21.1
24.7
24.3
21.8
23.8
18.7
23.9
21.4
18.4
20.1
20.8
21.4
20.1 2 2 .7 20.6
19.7
21.9
21.0 21.2
23.3
19.1
22.8
20.4
16.9
19.5
Company Sanitized. Does not contain TSCA CBI
- 429 -
90-Day Oral Gavage Stud|SyuibncRhraotnsic Toxicity
Food Cons. Food Cons.
g/anm/day g/anm/day
Day '77
Day 84
Food Cons
g/anm/day Day 91
Female, VI 5 mg/kg/day
655054 655038 655034
655039 655029
655067 655020
655087 655066
655042
655059 655064
655050 655021
655017
20.7
21.6 20.6 22.2
19.4
18.6
23.3
20.0
23.3 24.1
18.7
22.9
21.4 17.0
20.4
19.2
21.8
20.5
20.2
19.0
18.5
22.9
21.2 22.0 22.2
19.3
21.1 20.1
17.3
19.5
19.8
20.8 20.6
19.4
20.1
19.7
20.6 22.1
20.4
21.4
18.7
21.4
21.2
17.1
20.2
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
430
Q 90t-aD^aByBOBraBl GMaBvaBgeBS0tSuduybcinhRroantsic Toxicity
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons,
g/anm/day Day 7
Food Cons. Food Cons.,
g/anm/day g/anm/day
Day 14
Day 21
Female, VIII 25 mg/kg/day
Food C ons. Food Cons,
g/anm/day g/anm/day
Day 28
Day 35
Food Cons. Food Cons,
g/anm/day g/anm/day
' Day 42
Day 49
Food Cons,
g/anm/day Day 56
Food Con s . Food Cons,
g/anm/day g/anm/day
Day 63
Day 70
655058 655076 655047
655055 655105 655078 655073 655011 655085
655012 655043 655082 655060 655056 655081
19.6 19.4 16.6
19.6 18.0
23.1
20.3
19.3
2 1 .7 22.0
18.5
21.2
18.0 16.5
19.4
19.0 18.7 18.2
18.8 17.4
22.8 21.0
19.8
21.4
20.-9
17.9
20.8
17.4
18.3
20.8
20.3 22.3 17.7 28.3 20.9
25.4
22.1
21.3 23.6
22.2
18.7 21.4 19.6 18.3 24.4
19.5
19.9
18.1
20.0
17.8
25.1
22.0 21.8
24.5
21.5
19.9
22.1
19.4
19.3
21.2
21.8 20.2
19.0
20.7 19.8
27.4
21.1 21.2
24.7
21.6
20.5
23.9 19.0 21.3
22.8
19.5 21.4 20.3 20.4 19.7
30.7 23.1
20.9 22.9
21.5 19.9
22.1 22.8
20.7 23.8
17.0 18.6 17.4 19.0 17.7 25.1 20.3
19.1
21.2
19.9 18.7
25.3
21.6 20.2
24.4
20.8
21.3 20.5
22.4
22.8
26.4
24.0
24.3
22.9
24.2
21.8 22.8
24.5
22.6
23.7
21.2
21.3
18.8
20.0 20.0
25.4
23.0 23.1
22.8 21.6
18.7 23.2
22.2
22.5
22.9
23.7
22.8
18.5
20.4 19.5
26.5
23.1
20.9
23.4
21.8 20.1 20.6
22.3
22.9
25.2
Company Sanitized. Does not contain TSCA CBI
-431 -
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
Food C o n s . Food C ons. Food Cons.
g/anm/day g/anm/day g/anm/day
Day 77
Day 84
Day 91
Female, VIII 25 mg/kg/day
655058 655076 655047 655055
655105 655078 655073 655011
655085 655012 655043 655082 655060 655056
655081
21.8 22.3 18.6 20.4 17.9 26.2
21.5 22.1 24.8 21.8 19.8 21.8 23.2 22.2 24.7
19.7 21.6 17.4
19.9 19.0 23.5 22.2 21.9 24.2 21.8
19.9 22.6 22.6 20.4 23.3
18.8 23.1 16.9 19.4 17.7 18.5
20.1 21.9 22.4 21.5
18.2 22.0 21.0 21.4
21.9
INDIVIDUAL FOOD CONSUMPTION
)
DuPont-9478
Company Sanitized. Does not contain TSCA C8I
-432-
90-Day Oral Gavage rtudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food cons,
g/anm/day Day 7
Food Cons, g/anm/day
Day 14
Female, X 125 mg/kg/day
Food Cons,
g/anm/day Day 21
Food Cons, g/anm/day
Day 28
Food cons,
g/anm/day Day 35
Food Cons g/anm/day
'Day 42
Food Cons, g/anm/day
Day 49
Food Cons, g/anm/day
Day 56
Food Cons. g/anm/day
Day 63
Food Cons, g/anm/day
Day 70
655097 655052 655063
655103 655026 655095 655023 655007 655053 655092 655046 655027 655104 655106 655024 655037
655088 655010 655077 655030 655075 655100 655049 655084 655061
18.4
18.6 16.2
19.9
18.8
20.2
19.4 18.4
19.7
19.6 19.3 19.3
19.5 14.7 19.7
19.5
22.0 21.1
18.6 20.7
20.7
22.6
16.0
18.3 17.3
19.3
18.9 16.7
21.3
19.1
23.1
20.0
19.2
20.2 20.1 20.6
20.5 21.3 16.7 19.6
22.1 22.8
21.4
20.1 21.6 22.2
23.0
18.2
18.6
18.7
21.2
19.4 18.2
22.3
20.7 23.5
21.6
19.5
22.9
21.5 24.5 20.3
22.1
16.9
21.4
23.3
26.4 21.9
20.9
22.8
23.8
23.4
18.6 19.8
20.1
19.2
20.4 17.3
20.6 20.1
23.6
21.8
20.9
22.2
21.3 23.3
20.2
22.7 16.4
20.4 23.3
24.0
21.1
20.7
22.2
23.2
23.2
17.9
18.6
19.7
20.8
19.1
17.2 20.4
21.5
22.8 21.1
22.9 23.1
20.7 23.9
20.2
24.4 16.9
21.5 23.8
23.8
21.6 20.2 21.1
25.9 23.7 18.8
20.0
20.5
22.2
19.6 17.7
19.9
20.6
24.5
21.1
19.8
22.2
19.6
21.8
19.6
22.2
15a.7
22.8
22.5 20.9
19.2
21.6
24.7 23.2
17.2 19.1
20.0
19.8
18.0 15.2
18.6
17.7 21.7
20.0
18.9
19.8
19.1 23.8
20.8
24.3 15.8
22.1
22.5
28.0
22.8
20.4 21.4
28.2 23.5
15.1 19.7
19.1
22.0 21.1
18.7
21.4
21.8
25.8
20.6
21.7
24.2
21.4 24.5 20.7 24.3 16.6
21.2
23.3
21.2 22.1
19.7
23.8
25.9 26.1
16.6
17.5
21.2
21.3
20.2
16.7
21.3
20.1
25.9
20.2
21.5
22.2
19.6
21.2
19.0 21.9 16.5
19.7
22.1
23.3 20.9
18.8
20.1
23.925.4
16.9
18.7
20.1
21.0
19.9 17.8
19.5 21.5
24.4
20.0
19.1 21.5
19.3
22.6
18.4 23.1 16.5
21.5
22.0
21.5 22.3
19.2 17.8 22.7 24.1
16.4
19.9 20.5
Company Sanitized. Does not contain TSCA CBI
Inaccurate data; food consumption value not calculated.
9B0-BDBayBOBraHl GMaHvaBgeBS^tSuduybcinhRroantsic Toxicity
DuPont-9478
INDIVIDUAL FOOD CONSUMPTION
Food Cons. g/anm/day
Day 77
Food C ons. Food Cons.
g/anm/day g/anm/day
Day 84
Day 91
Female, X 125 mg/kg/day
Food Cons. Food Cons.
g/anm/day g/anm/day
Day 98
Day 105
Food Cons. Food C o n s . Food Cons.
g/anm/day g/anm/day g/anm/day
'Day 112
Day 119
Day 126
Food Cons..
g/anm/day . Day 133
Food Cons
g/anm/day Day 140
655097
655052 655063 655103 655026
655095 655023 655007
655053 655092 655046 655027 655104 655106 655024 655037 655088 655010 655077 655030
655075 655100 655049 655084 655061
22.0
18.4
17.2 19.3 19.0
26.2 19.3 20.3
22.6 20.1
23.5 18.3 22.9 15.7 19.9 21.4
20.3 19.1 19.6
20.2
20.7 23.7 16.1 18.7
19.5
23.7
18.5
20.4
20.8 6.1
18.6 20.7
23.8
21 .,8 2 0 .3
24.4 19.7
25.3
17.5
20.1 22.6 21.1
20.7 18.4
23.4
27.2
22.1
15.0
19.8 19.2
20.5
19.0 20.7
19.3 18.6
23.5
21.0
23.5 21.4 18.4 24.0 12.7 25.2 16.8
20.1
22.3 19.4
23.2
18.9 24.4 19.2
20.8
14.4 16.2
17.8
20.5
21.2
' 17.2
18.1
22.6
22.4 21.5 15.2
17.0
18.5
19.0 24.1
19.4 18.2 22.4
22.2
23.3
14.8 20.5 17.7
19.7
17.9
21.6
20.3
20.6
24.4
24.6 14.9
18.9 17.2
21.3
21.8 20.0 20.1
24.3
27.9 24.8 14.8
18.2
18.1
23.4 25.6 22.4 18.7 28.1
27.0 26.6 15.0 17.7 19.6
23.5
26.6 23.5 17.8 27.5
26.0 27.4
14.9 18.4 18.5
22.6
24.6 25.9 18.7
26.9 24.5 28.8
18.6 21.7 22.5
Company Sanitized. Does not contain TSCA CBI
-434-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage Study in Rats Toxicity
INDIVIDUAL FOOD CONSUMPTION
Food Cons, Food C ons. Food Cons,
g/anm/day g/anm/day g/anm/day
Day 147
Day 154
Day 161
Female, X 125 mg/kg/day
Food Cons, g/anm/day
Day 168
Food Cons, g/anm/day
Day 175
Food cons
g/anm/day Day 182
655097 655052 655063 655103 655026
655095 655023 655007 655053 655092 655046 655027 655104 655106 655024 655037 655088 655010 655077 655030
655075 655100 655049 655084
655061
22-,.0 22 .5
23..9
19,.4 26,.9
25..2
26..5
15,.4.
20..0 17,.1
23..4
24..9
24..5
18..8 28..6
24..9
26,.0
15..7
17..9
17..4
22 3 22 4 24 6
18 3 24 5
26 5 27 5
15 3 17 9
17 6
22.3
26.3 29.6 18.6 29.3
27.5 29.2
16.3 25.5 20.5
21.4 23.2
20.9 18.8 28.7 23.2
. 23.6 15.4 18.2
17.6
17.6
21.8
20.9 18.9 24.5
22.9 23.7
17.5 20.5 17.4
-435-
DuPont-9478
^ ^ m m ^ B H 0 ^ S u b c h r o n i c Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
APPENDIXE INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
-436-
Company Sanitized. Does not contain TSCA CBi
Company Sanitized. Does not contain TSCA CBI
(9H0-MDaHy OHraHl IGHavBagHe SStuudbycihnrRoantsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
MI
654928 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right.
Sacrificed by design
MI
654993 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654929 General-observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Shoulder, Bilateral, Brown
Sacrificed by design
MI
654972 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654950 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hyperreactive
Hair Loss, Forepaw, Bilateral
Protrusion, Umbilical Hernia
MI
654953
Sacrificed by design General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 0-42,49-93 . 48,93 93 0-42,49-93 48,93 93 0-21,91-93 48,93 28-42,49-84 93 0-42,49-93 48,93 93 0-14 48,93 70-93 28-42,49-93 21-42,49-93 93 0-42,49-93 48,93 93
-437-
)
DuPont-9478
jSubchronic Toxicity 90-Day Oral Gavage Study in Rats
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
MI
654925
Observation General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654987 General observation, No Abnormality Detected
Eye Observations, Enophthalmus, Right
Eye Observations, Bled via Orbital for Clin Path, Right
Discharge, Eye right, Black
Sacrificed by design
MI
654903 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MX
654966 General observation, No Abnormality Detected
Eye Observations, Bled via .Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MX
654997 General observation, No Abnormality Detected
Eye Observations, Bled, via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
MI
654971
Sacrificed by design General observation. No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Right
Days 0-42,49-93 48.93 93 0-21,35-42,49-93 28 48.93 28 93 0-42,49-93 48.93 93 0,7,14-84,91,98-175 10,21 0-4,35,56,77,90,94-105,119,133,154,175 175 0,7,14-84,91,98-175 56 0-4,10,21,35,77,90,94-105,119,133,154, 175 175 0,7,14-84,91,98-133 147-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175
-438-
_9_0_-D_ ay Oral Gavage_StufdSyubinchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
MI
654971 Discharge, Eye right, Black
Sacrificed by design
MI
65.4939 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Corneal Opacity, Right
Discharge, Eye right, Black
Hair Loss, Forelimb, Bilateral
Hair Loss, Forelimb, Left
Hair Loss, Forepaw, Bilateral
Hair Loss, Forepaw, Left
Swollen Observations, Face
Sacrificed by design
654919 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
Discharge, Nose, Black Hair Loss, Nose Wound, Superficial, Nose Sacrificed by design
Days 140-147 175 0,7,14-21 94-105,119,133,154 0-4,10,21,35,56,77,90,175 91.98- 175 91.98- 105 42-84,91,98-175 28-35 42-84,91,98-175 28-35 91,98 175 0,7,14-84,91,105,126-140,168-175 35 0-4,10,21,56,77,90,94-105,119,133,154, 175 98 119 112,147-161 175
Company Sanitized. Does not contain TSCA CBI
-439-
Company Sanitized. Does not contain TSCA CBI
___________
LSubchronic Toxicity
90-Day Oral Gavage Study in Rats
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
MX
654994 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Face, Red
Stain Fur/Skin, Head, Red
Sacrificed by design
MI
654949 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
MI
654992
Accidentally killed General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Face, Red
Stain Fur/Skin, Head, Red
Sacrificed by design
MI
654909 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hyperreactive
Stain Fur/Skin, Dorsal Body, Red
Sacrificed by design
MI
654924 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654943 General observation. No Abnormality Detected
Days 0-140 183 147-183 147-183 183 0-183 183 183 0-140 183 147-183 147-183 183 0-119,133-140 183 126 147-183 183 0-183 183 183 0-126
-440-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
MI
654943 Eye Observations, Bled via Orbital for Clin Path, Right
Discharge, Eye right, Black
Hair Loss, Face, Right
Sacrificed by design
MI
654915 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654927 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654956 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Face, Red
Sacrificed by design
MX
654910 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MI
654936 General observation, No Abnormality Detected
Eye observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 183 133-161,183 168-183 183 0-183 183 183 0-183 183 183 0-119 183 147-183 126-183 183 0-183 183 183
0-42,49-93 48,93 93
-441 -
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyubirci hRraotns_ic__T_o_x_i_c_it_y
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA'
Sex Group Animal ' Observation M III 654913 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design III 654947 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design III 654995 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design III 654938 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design III 654941 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design III 654946 General observation, No Abnormality Detected Eye Observations, Bled via. Orbital for Clin Path, Right Sacrificed by design III 654960 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design
Days 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-35 48.93 49-93 42,49-93 93
-442-
)
DuPont-9478
0 t9h0M-DaHyIOBrHal HGaMvaBge^S|StuudbycihnrRoantsic Toxicity
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation M III 654908 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Side, Right Sacrificed by design M III 654984 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design M III 654932 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design M I'll 654948 General observation, No Abnormality Detected Eye Observations, Bled via,Orbital for Clin Path, Right
M III
654904
Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Stain Fur/Skin, Forelimb, Left, Brown Stain Fur/Skin, Shoulder, Left, Red Stain Fur/Skin, Ventral body, Red Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left
Days
0-42,49-70
48.93
77-93
93
0-42,49-93 93
'
48
93
0-42,49-93
48.93
93
0,7,14-56,98-126
0-4,10,21,35,56,77,99,94-105,119,.133, 154,175
161-175
133-154
63-84,91
154-175
154-175
175
0,7,14-84,91,98.-175
10
Company Sanitized. Does not contain TSCA CBI
-443-
0 90^-Day Oral Gavage fS^tPuSdyubinchRroatnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal M III 654904
M III 654954
Observation Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design General observation. No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Right
M III
Hair Loss, Forelimb, Bilateral Sacrificed by design General observation, No Abnormality Detected Eye Observations, Exophthalmus, Bilateral Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Stain Fur/Skin, Dorsal Body, Red Sacrificed by design 654988 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right Hair Loss, Forepaw, Left Hair Loss, Forepaw, Right Sacrificed by design
Days 0-4,21,35,56,77,90,94-105,119,133', 154,175 175 0,7,28-84,91,98-105 112-175 0-4,10,21,35,56/77-, 90,94-105,119,133, 154,175 14-21 175 0,7 21 35 10 0-4,21,56,77,90,94-105,119,133,154,175 14-84,91,98-175 154-175 175 0,7,49-77,91,98,133-175 42 0-4,10,21,35,56,77,90,94-105,119,133,154,175 14-42 105-126 84 175
Company Sanitized. Does not contain TSCA CBI
-444-
90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND
Sex Group Animal Observation
MV
655005 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654907 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654980 General- observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654959 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654961 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654916 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Comments, animal out of cage
Stain Fur/Skin, Ventral body, Brown
Stain Fur/Skin, Face, Brown
Wet Fur, Ventral body, Ventral
Sacrificed by design
Company Sanitized. Does not contain TSCA CBI
-445-
MORTALITY DATA
Days 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 0-42,49-63,77-93 48.93 70 70 70 70
93
DuPont-9478 '
90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
MV
654911 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Forelimb, Left
Hair Loss, Forepaw, Bilateral
Sacrificed by design
MV
654917
General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
MV
654998
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
MV
654970 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
MV
654926
Discharge, Nose, Black Discharge, Eye right, Black Sacrificed by design General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 0-7 48.93 35-42,49-93 14-42,49-93 93 0-42,49-93 48.93 93 0-42,49-93 48.93
93
0,7,14-35,56-84,105-175 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 42-49,98 91 175 0,7,14-28,42-84,91,98-175 35 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 175
Company Sanitized. Does not contain TSCA CBI
-446-
90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
MV
654918
Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
MV
654981
Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
MV MV
Stain Fur/Skin, Dorsal Body, Red Stain Fur/Skin, Face, Red Sacrificed by design 654969 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, excessive, bleeding Sacrificed by design 654967 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design
bays 0,7,14-84,91,98-175 0-4-, 10,21,35,56,77,90,94-105,119,133, 154.175 175 0,7,14-84,91,98-147 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 154-175 154-175 175 0,7,14-84,91,98-175 105,154 0-4,10,21,35,56,77,90,94-98,119,133,175 133 175 0-42,49-93 48,93 93
Company Sanitized. Does not contain TSCA CBI
-447-
Company Sanitized. Does not contain TSCA CBI
ISubchronic Toxicity 90-Day Oral Gavage Study in Rats_________
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
M VII 655001 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VIX
654975 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VII 654922 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VII
654940 General observation, No Abnormality Detected
" Eye Observations, Bled via.Orbital for Clin Path, Right
Vocalization, No Abnormality Detected
Hair Loss, Forelimb, Bilateral
Hair Loss, Forepaw, Bilateral
Sacrificed by design
M VII
654930 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VII
654958 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 0-42,49-93 93 48 93 0-42,49-93 93 48 93 0-42,49-93 48,93 93
0
48,93 21,28,35,42 28-42,49-93 7-42,49-93 93 0-42,49-93 48,93 93 0-42,49-93 48,93 93
-448-
DuPont-9478
,)
Subchronic Toxicity
90-Day Oral Gavage Study in Rats
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND
Sex Group Animal Observation
M VII 654952 General observation. No Abnormality Detected
Absent, Toe, Forepaw Right
Eye Observations, Bled via Orbital for Clin Path, Right
Swollen Observations, Forepaw, Right
Sacrificed by design
M VII 654923 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
M VII
654989
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VII - 655006 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
M VII
654920 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
M VII
654912
Stain Fur/Skin, Head, Red Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped Sacrificed by design
-449-
DuPont-9478
MORTALITY DATA
Days 0-28 35-42,49-93 48.93 35-42,49-63 93 0-42,49-93 48.93 93 0-42,49-93 48.93 93 . 0-42,49-93 48.93 93 0,7,14-84,91,98-147 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 154-175 175
0,7,14-84 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 86,91,98-175
175
'90-Day Oral Gavage S^tuSduybicnhRroantsic Toxicity
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
M VII
654934
Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right
M VII
654964
Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
M VII
654933
Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days
0,7,14-84,91,98-175
56
0-4,10,21,35,77., 90,94-105,119,133,154, 175
175
0,7,14-84,91,98-175
0-4,10,21,35,56,77,90,94-105,119,133, 154.175
175
0,7,14-84,91,98-175 0-4,10,21,35,56,77,90,94-105,119,133, 154.175
175
Company Sanitized. Does not contain TSCA CBI
-450-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
M IX
654983' General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Hyperactive
Sacrificed by design
M IX
654965 General observation, No Abnormality Detected
Eye Observations, Enophthalmus, Right
Eye Observations, Exophthalmus, Right
Eye Observations, Bled via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Corneal Opacity, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Discharge, Eye right, Black
Hair Loss, Face, Right
Wound, Superficial, Head
Sacrificed by design
M IX
654979 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
M IX
654986 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Days 0-35 48,93 49-93 42,49-84 93 0-42 63-93 56 93 48 63-93 77-93 84-93 49-56 63-93 70-77 93 0-42 48,93
49-93 93 0-42,49-70 48,93
-451 -
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
w90~-DjfattyHOHraHl GHaMvaHgeBSltSuudybcinhRroantsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
M IX
654986
Observation General Teeth Observations, Clipped
General Teeth Observations, Striated
Sacrificed by design
M IX
655003 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
M IX
654921 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
M IX
654996 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Sacrificed by design
.
M IX
654951 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
H IX
654955 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General' Teeth Observations, Clipped
Days 75-93 75-93 93 0-42 48,93 49-93 93 0-42 48,93 49-93 93 0-42 48,93 75-93 49-93 93 0-42,49-56 48,93
63-93 ' 93
0-42,49-70 48,93 77-93
-452-
)
DuPont-9478
90-Day Oral Gavage Stu}dSyuibnchRraotns_ic__T_o_x_i_c_it_y
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
M IX
654955 General Teeth Observations, Striated
M IX
654914
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Aggressive Behavior
Hyperreactive
Discharge, Nose, Red
Sacrificed by design
M IX
654937 General observation. No Abnormality Detected
Eye Observations, Bledvia Orbital for Clin Path, Bilateral
Eye Observations, Bledvia Orbital for Clin Path, Right
Eye Observations, Bledvia Orbital for Clin Path
General Teeth Observations, Clipped
General Teeth Observations, Striated
Sacrificed by design
M IX
654962 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped General Teeth Observations, Striated Sacrificed by design
Days 77-93 93 0-35 48,93 49-93 42,84-93 70-93 42 93 0,7,14-12 77 0-4,10,21,35,56,90,94-105,119,133,154 175 126-175 49-84,91,98-175 175 0,7,14-42 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 77-84,91,98-17549-84,91,98-175
175
Company Sanitized. Does not contain TSCA CBI
-453-
_90_-_D__ay__O__ra_l_G__a_v_a_g_e StuIdSyubinchRraotnsic Toxicity
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal M IX 654982
Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
M IX
654931
General Teeth Observations, Clipped General Teeth Observations, Striated Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
M IX M IX
General Teeth Observations, Clipped General Teeth Observations, Striated Sacrificed by design 654906 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped General Teeth Observations, Striated Sacrificed by design 654985 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Absent General Teeth Observations, Clipped General Teeth Observations, Striated
Days 0,7,14-42 0-4,10,21,35,56,77,90,94-105,119,133, 154.175 63-84,91,98-175 49-84,91,98-175 17S 0,7,14-56 0-4,10,21,35,56,<77,90,94-105,119,133, 154.175 74- 84,91,98-175 63-84,91,98-175 175 0,7,14-70 133,154 90 0-4,10,21 ,'35,56,77,94-105,119,175 75- 84,91,98-175 84,91,98-175 175 0-7 183
91-183 77-183 49-183
-454-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral GaVage tudSyuibncRhraetrsnie Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
M IX
654985 Discharge, Nose, Black
Discharge, Eye right, Black
Hair Loss, Forelimb, Bilateral
Hair Loss, Forepaw, Bilateral
Sacrificed by design
M IX
654978 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
M IX
654974 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth observations. Clipped
General Teeth Observations, Striated
Aggressive Behavior
Hyperreactive
Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Face, Red
Sacrificed by design
M IX
654990 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Hair Loss, Forelimb, Bilateral
Days 77 77-98 35-147 14-147 183 0-42,183 183 49-182 183 0-42 183 75-183 49-183 112-119 161-168 147-183 175-183 183 0-42 183 112-183
49-183 56-175
-455-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StjudSyubinchRraotns_ic__T_o_x_i_c_it_y
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
M IX
654990 Hair Loss, Forelimb, Left
Hair Loss, Forepaw, Bilateral
Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Face, Red
Sacrificed by design
M IX
654976 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Discharge, Nose, Black
Hair Loss, Forelimb, Right
Hair Loss, Forepaw, Bilateral
Hair Loss, Forepaw, Right
Sacrificed by design
M IX,
654957 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Wound, Superficial, Shoulder, Right
Sacrificed by design
M IX
654973 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Days 182-183 70-183 147-183 147-183 183 0-14 183 77-183 175-183 56 ' 21-56 63-84 183 0-7 183 91-183 49-183
14-56 183 0-42 183 126-183 49-182
-456-
)
DuPont-9478
Company Sanitized. Does not contain TSCA C8I
^^90-D ayaOHraHl GflalvHagMe ^SStuudbycinh rRoantsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
M IX
654973
Observation Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Head, Red
Sacrificed by design
M IX
654977 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Head, Red
Sacrificed by design
M IX
654942
General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Head, Red
Sacrificed by design
M ' IX
654991 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Stain Fur/Skin, Dorsal Body, Red
Stain Fur/Skin, Head, Red
Sacrificed by design
Days 147-183 147-183 183 0-140,175-183 183147-168 183 0-42 183 84-183 49-183 147-183 147-182 183 0-56 183 63-183 77-182 147-183 147-183 183
-457-
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
^ j9j0^-^D^aymOmralmGa^vBageS Sutubdcyhinr oRantsi c Toxicity
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F II
655031 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655107 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655098 General, observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Wound, Superficial, Shoulder, Left Sacrificed by design
F II
655016 General observation, No Abnormality Detected
Eye Observations,. Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via .Orbital for Clin Path, Right
Sacrificed by design
F II
655079 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655036
General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655025 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Dark, Right
Days 0-94 49,94 94 0-94 49,94 94 0,21-94 49,94 7-14 94 0-94 49 94 94 0-94 49,94 94 0-94 49,94 94 0-42,56-94 49,94 49
-458-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
^ j9^0^-D^a^yBOrHalHGaBva^gSe Sutubdcyhinr oRantsi c Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
F II 655025 F II 655099
F II 655032
F II 655083
F II 655093
Observation Sacrificed .by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Wound, Superficial, Shoulder, Right Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via. Orbital for Clin Path, Right Arches back during handling Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design General observation, No Abnormality Detected Eye Observations, Closed, Bilateral Eye Observations, Enophthalmus, Bilateral Eye Observations, Enophthalmus, Right Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, corneal Opacity, Right Eye Observations, tail vein
Days
94 0-7,21-94 49,94 14 94 0-35,49-94 49,94 42 94 0-94 49,94 94 0 119-175 42-84,91,98-112 21-35 28-35 7,14 10,21 0-4,35,56 35-84,91,98-175 7,14-28 77,90,94-105,119
-459-
)
DuPont-9478
90-DayC>ral Gavage Stu|dSyuibnchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
F II 655093
F II 655045
Observation Discharge, Eye left, Black Discharge, Eye right, Black Hair Loss, Face, Left Hair Loss, Face, Right Scab, Face Sacrificed by design General-observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
F II
655065
Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
F II
655074
Hair Loss, Inguen, Right Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
F II
655035
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Forelimb, Bilateral
. Hair Loss, Forepaw, Bilateral
Ear twitch, Bilateral
Days
28-35 7,14 35-42 21-28 21-49 175 0,7,14-84,91,98-175 015- 44,,11705,2 1 ,3 5 ,5 6 ,7 7 ,9 0 - , 9 4 -1 0 5 ,1 1 9 ,1 3 3 , 175 0,7,14-28,49-84,91,98-175 015-44,,1107 5,2 1 ,3 5 ,5 6 ,7 7 ,9 0 ,9 .4 - 1 0 5 ,1 1 9 ,1 3 3 , 35-42 175 0,7,14-84,91,98-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 175 0-35 183 56-183 56-183 42-49
Company Sanitized. Does not contain TSCA CBI
-460-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F II
655035
Ear twitch Sacrificed by design
F II
655009 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hyperactive
Hyperreactive Discharge, Eye bilateral, Black
Discharge, Eye right, Black
Discharge, Eye right. Red
Ear twitch, Bilateral
Sacrificed by design
F II
655068 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655019 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655062 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Forelimb, Bilateral
Hair Loss, Forepaw, Bilateral
Sacrificed by design
Days 63-70 183 0-14,28-35,56-70,154-182 183 77-140 42-49 98-105,183 112 126-147 21 183 0-183 183 183 0-183 183 183 0-7
183 14-183. 28-183 183
-461 -
DuPont-9478
9_0__-D__a_y_O__r_al__Gavag_e__S_tuSduybicnhRroantisc Toxicity
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F II
655109 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch, Bilateral
Arches back during handling
Sacrificed by design
F II
655101 General observation. No Abnormality Detected
Eye Observations, Bled via.Orbital for Clin Path, Right
Hair Loss, Forelimb, Bilateral
Hair Loss, Forepaw, Bilateral
Sacrificed by design
F II
655072 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F II
655015 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right.
Stain Fur/Skin, Head, Red
Sacrificed by design
F II
655071 General observation. No Abnormality Detected
Accidentally killed
F II
655022 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Stain Fur/Skin, Head, Red
Sacrificed by design
Days 0-21,35-183 183 28 28 183. 0-7,70-77,154-183 183 14-63,84.-147 28-63 183 0-183 183 183 0-147,182-183 183 154-175 183 0-14 19 0,7,14-84,91,98-133
0-4,10,21,35,56,77,90,94-105,119,133,154,175 140-175 175
-462-
Company Sanitized. Does not contain TSCA CBI
^ 90-DJHayHOHraHl GHaBvaHgBe SJtSuudybcinhRroantsic Toxicity
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F IV
655086 General observation, No Abnormality Detected
Eye Observatipns, Bled via Orbital for Clin Path, Right
F IV
655041
Sacrificed by design General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Forelimb, Left
Hair Loss, Forepaw, Left
F IV
655108
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Vocalization, No Abnormality Detected
Hyperactive
Ear twitch, Bilateral
Arches back during handling
Sacrificed by design
F IV
655040 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch, Bilateral
Arches back during handling
Sacrificed by design
F IV
655044 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Misshapen Observations, Ear, Bilateral
Days 0-94 49.94 94 0-14,70-94 49.94 21-63 21-63 94 0-14,28,49-70,84,94 49.94 35,42 35-42 21.77 21,77,91 94 0-21,35-70,84-94 49.94 28 28.77
94 0 49.94 35-94
-463-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
^ ^90^-JDIaHy OBraHl GHavBag^e uStbudcyhinr oRnatsi c Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F IV
655044 Misshapen Observations, Ear, Left
Sacrificed by design
F IV
655013 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F IV
655089 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F IV
655091 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Discharge, Mouth, Clear
Wet Fur, Hindpaw, Bilateral
Wet Fur, Thoracic, Ventral,.
Wet Fur, Face, Right
Sacrificed by design
F IV
655033 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Dark, Left
Sacrificed by design
F IV
655090 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F IV
655051 General observation, No Abnormality Detected
Days 7-28 94 0-94 49,94 94 0-94 49,94 94 0-7,21-94 49,94 14 14 14 14 94 0-42,56-94 49,94 49 94 0-94 49,94 94 0,7,14-84,91,98-175
-464-
)
DuPont-9478
90-Day Oral Gavage StudyuibnchRraotnsic Toxicity
>
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F IV
655051 Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F IV
655018 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Dark, Right
Discharge, Eye right. Black
F IV
655096
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Forelimb, Right
Hair Loss, Forepaw, Right
Sacrificed by design
F IV
655057 General observation, No Abnormality Detected
Eye Observations, Exophthalmus, Right
Eye Observations, Bled via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Corneal Opacity, Right
Hair Loss, Face, Right
Sacrificed by design
F IV
655028 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 0-4,10,21,35,56,77,90,94-105,119,133,154,175
175 !
0,7,14-84,98-105,133-175 90 0-4,10,21,35,56,77,94-105,119,133,154,175 91,112-126 91 175 0,7,14-28,49-56,119-175 0-4,10,21,35,56,77,90,94-105,119,133,154,175 35-42 63-84,91,98-112 175 0,7,14-84,91,98-119,133 147-175 154,175 0-4,10,21,35,56,77,90,94-105,119,133 140-175 126 175 0,7,14-84,91,98-175 0-4,10,21,35,56,77,90,94-105,119,133,154,175 175
-465-
Company Sanitized. Does not contain TSCA CBi
_90-_D_a_y__O_ral G_avage StJuSduybinchRroatnsi_c__T_o_x_i_c_it_y
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F VI
655054 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F VI
655038 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F VI
655034 General,observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch, Bilateral
Arches back during handling
Sacrificed by design
F VI
655039 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F VI
655029 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Comments, excessive salivation
Stain Fur/Skin, Chin, Red
Stain Fur/Skin, Face, Red
Sacrificed by design
F VI
655067 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch. Bilateral
Days 0-94 49,94 94 0-94 49,94 94 0-21,35-77,94 49,94 28 28,84-91 94 0-94 49,94 94 0-35,49-94 49,94 40 42 42 94
0-35,49-94 49,94 42
-466-
)
DuPont-9478
^ P H H H g ^ S u b c h t o n i c Toxicity - ay Oral GavageStudy in Rats ___
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F VI
655067 Arches back during handling
Sacrificed by design
F VI
655020 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch. Bilateral
Arches back during handling
Sacrificed by design
F 'VI
655087 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hyperactive
Arches back during handling
Sacrificed by design
F VI
655066 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F VI
655042 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital' for Clin Path, Right
Sacrificed by design
F VI
655059 General observation. No Abnormality Detected
Eye Observations, Enophthalmus, Right
Eye Observations, Bled via Orbital for Clin Path, Left
Eye Observations, Bled via Orbital for Clin Path, Right
Days 42 94 0-21,35-94 49.94 28 28 94 0-21,35-94 49.94 28 28 94 0-94 49.94 94 0-94 49.94 94 0,56-84,91,98 112-175
133 0-4,10,21,35,56,77,90,94-105,119,154, 175
Company Sanitized. Does not contain TSCA C8I
-467-
?0-Day Oral Gavage StudsyuibnchRraotnsic Toxicity
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
F VI
655059 Eye Observations, Corneal Opacity, Right
Eye Observations, Dark, Right
Hair Loss, Forelimb, Bilateral
Hair Loss, Forepaw, Bilateral
Hair Loss, Forepaw, Left
Sacrificed by design
F VI
655064 General, observation, No Abnormality Detected
.Eye Observations, Bled via Orbital for Clin Path, Right
F VI
655050
Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
F VI
655021
Discharge, Eye right, Black Sacrificed by design General observation. No Abnormality Detected Eye Observations,. Bled via Orbital for Clin Path, Right
F VI
655017
Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days
119-175 105-133 28-49 28-49
7,14-21
175 0,7,14-84,91,98-175
0-4,10,21,35,56,77,90,94-105,119,133, 154,175 175 0,7,14-84,98-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 91
175 0,7,14-84,91,98-175
0-4,10,21,35,56,77,90,94-105,119,133, 154,175
175 0,7,14-84,91,98-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 175
Company Sanitized. Does not contain TSCA CBI
-468-
Company Sanitized. Does not contain TSCA CBi
C>^-DpaHy BOHralBGHavHagBe^SStuudbycihn rRoantsi_c__T_o_x_i_c_it_y
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation F VIII 655058 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Breathing Observations, Noise Sacrificed by design F VIII 655076 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Sacrificed by design F VIII 655047 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Ear twitch, Bilateral Arches back during handling Sacrificed by design F VIII 655055 General observation. No Abnormality Detected Eye Observations, Bled via.Orbital for Clin Path, Right Hyperactive Ear twitch, Bilateral Arches back during handling Sacrificed by design, F VIII 655105 General observation, No Abnormality Detected , Eye Observations, Bled via Orbital for Clin Path, Right Hyperactive
Days 0-56,70-94 49,94 63 94 0-35 49,94 49-94 42 94 0-28,42-94 49,94 35 35 94 0-77,91-94 49,94 84 84 84 94
0-21,35-94 49,94 28
-469-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage Stu^dSyuibnchRraotnsic Toxicity
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animai
F Vili 655105
Observation Arches back during handling
Sacrificed by design
F Vili 655078 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hyperactive
Ear twitch, Bilateral
Ear twitch
Sacrificed by design
F Vili 655073 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
F Vili 655011 General observation, No Abnormality Detected
Eye Observations, Bled via .Orbital for Clin Path, Right
Sacrificed by design
F Vili 655085 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
F Vili
655012
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Hair Loss, Shoulder, Right
Sacrificed by design
F Vili 655043 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Bilateral
Days
28 94 . 0-28,42-56,70-9 49,94 35,63 35 63 94 0-94 49,94 94 0-94 49,94 94 0-94 49,94 94 0-7,21-94 49,94 14 94 0,7,14-84,91,9 175
-470-
)
DuPont-9478
' 90-Day O_r_a_l Gavage StJuSduybinchRroatnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal F VIII 655043
Observation Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design F VIII 655082 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
F VIII
655060
Hair Loss, Forelimb, Left Stain Fur/Skin, Head, Red Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
Eye Observations, Dark, Right Sacrificed by design F VIII 655056 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye. Observations, Bled via Orbital for Clin Path, Right Hair Loss, Face, Right Wound, Superficial, Face Sacrificed by design F VIII 655081 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
Sacrificed by design
Days 0-4,10,21,35,56,77,90,94-105,119,133, 154 175 0,7,14-84,91,98-147 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 175 154-175 175 0,7,14-84,105-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 . 91,98 175 0,7,14-35,56-84,91,98-175
35,56 0-4,10,21,77,90,94-105,119,133,154,175 42-49 42 175 0,7,14-84,91,98-175 0-4,10,21,35,56,77,90,94-105,119,133, 154,175 175
Company Sanitized. Does not contain TSCA CBi
-471-
Company Sanitized. Does not contain TSCA CBI
iSubchronic Toxicity 90-Day Oral Gavage Study in Rats
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
Fx
655097 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655052 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General. Teeth Observations, Striated
Sacrificed by design
FX
655063 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655103 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Hyperreactive
Sacrificed by design
FX
655026 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655095 General observation, No Abnormality Detected
Days' 0-42 49,94 49-94 94 0-42 49,94 49-94 94 0-42 49,94 49-94 94 0-56 49,94 84-94 77-94 63-94 94 0-42
49,94 49-94 94
0-14
-472-
}
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
"50-Day Oral Gavage StufdSyubinchRraotnsic Toxicity
)
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
FX
655095 Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Hair Loss, Forelimb, Bilateral
Ear twitch, Bilateral
Arches back during handling
Sacrificed by design
FX
655023 General, observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Arches back during handling
Sacrificed by design
FX
655007 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655053 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655092 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Hyperactive
Days 49,94 49-94 21-42 35 35 94 0-21,35-42 49,94 49-94 28,84 94 0-42 49,94 49-94 94 0-42 49,94 49-94 94 0-42 49,94
77-94 77-84
-473-
)
DuPont-9478
90-Day Oral Gavage StupdSyuibncRhraotnsic Toxicity
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA'
Sex Group Animal Observation
FX
655092 Hair Loss, Forepaw, Bilateral
Arches back during handling
Sacrificed by design
FX
655046 General observation, No Abnormality Detected
Eye Observations,Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
General.Teeth Observations, Striated
Sacrificed by design
J
FX
655027 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Bilateral
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations,. Striated
Discharge, Eye right, Black
Wound, Deep, Mouth
Comments, animal caught teeth on fcage, nose was stuck
Swollen Observations, Face
Swollen Observations, Nose
Sacrificed by design
FX
655104 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Days 49-94 70 94 0,7,14-70 133 0-4,10,21,35,56,77,90,94-105,119,154,175 77-84,91,98-175 175 0,7,14-42 133,154,175 0-4,10,21,35,56,77,90,94-98,105,119 104- 175 49-84,91,98-140 161-175 112-119 104 105- 119 105 175 0,7,14-42
0-4,10,.21,35,56,77,90,94-105,119,133, 154,175 126-175 49-84,91,98-175
-474-
( P ^ J h H H H H B ^ S u b c h r o n ic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-9478
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal
FX
655104
FX
655106
Observation Sacrificed by design General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
FX
655024
Sacrificed by design General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
FX
655037
Sacrificed by design General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right ' General Teeth Observations, Striated
FX
655088
Sacrificed by design General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Discharge, Eye bilateral, Black
Discharge, Nose, Black
Comments, teeth caught in cage
Stain Fur/Skin, Forepaw, Bilateral, Red
Stain Fur/Skin, Face, Red
Days
175 0,7,14-42 0-4,10,21,35,56,77,90,94-105,119,133,154,175 49-84,91,98-175 175 0,7,14-42 0-4,10,21,35,.56,77,90,94-105,119,133,154,175 147-175 49-84,91,98-175 175 0-42 183 49-183 183 0-42 183 112-183 49-183 112 112 112 112 112
Company Sanitized. Does not contain TSCA CBI
-475-
Company Sanitized. Does not contain TSCA CBI
t V a v (MSubchronic Toxicity 90-Day Oral Gavage Study in Rats
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
'
FX
655088. Swollen Observations, Face
Days 112
FX
Sacrificed by design 655010 General observation. No AbnormalityDetected
183 0-35
Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped General Teeth Observations, Striated
183 77-183 49-183
Wound, Superficial, Mouth Ear twitch, Bilateral
119-126 42
Arches back during handling Sacrificed by design
42-49 183
FX
655077 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
0-35 183
General Teeth Observations, Striated Hyperactive Ear twitch, Bilateral Arches back during handling
49-183 70-140 42,70 42,70
FX
Sacrificed by design 655030 General observation, No Abnormality Detected
^ 183 0-42
Eye Observations, Bled via Orbital for Clin Path, Right
\ 183
FX
General Teeth Observations, Clipped General Teeth Observations, Striated Sacrificed by design 655075 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right
105-183 49-183 183 0-42 183
-476-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
90-DaJyHOrMal GMavaSgeuSbtucdyh inn .Rmatsc Toxicity
INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA
Sex Group Animal Observation
FX
655075 General Teeth Observations, Clipped
General Teeth Observations, Striated
Sacrificed by design
FX
655100 General observation. No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Clipped
General Teeth Observations, Striated
Sacrificed by design
FX
655049 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Stain Fur/Skin, Head, Red
Stain Fur/Skin, Neck, Red
Sacrificed by design
FX
655084 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
General Teeth Observations, Striated
Sacrificed by design
FX
655061 General observation, No Abnormality Detected
Eye Observations, Bled via Orbital for Clin Path, Right
Ear twitch, Bilateral
Arches back during handling'
Sacrificed by design
Days 112-183 49-183 183 0-42 183 105-183 49-183 183 0-49 183 56-182 91-183 126-183 183 0-42 183 49-183 183 0-28,42-84,98-183 183
35,91 35,91 183
-477-
)
DuPont-9478
Subchronic Toxicity "90-Day Oral Gavage Study in Rats
DuPont-9478
APPENDIX F INDIVIDUAOLPHOTPHHATLHMAOLMLOOGLYOGRIECPAOLRTOBASNEDRVATIONS
-478-
Company Sanitized. Does not contain TSCA CBI
Toxicity **90-Day Oral Gavage Study in Rats ___
DuPont-9478
NANCY M. BROMBERG, V.M .D., M.S. EYE CLINIC FOR ANIMALS 611 MASSACHUSETTS AVE BETHESDA,MD 20816
STUDY INFORMATION:
Study No. (3690 102fl HSp#e:c2ies:4B i6t 9 1 J
Study Director: Greg Ladies
OPHTHALMOExLaOmGinICatAioLn EDXatAe;MMINayAT17IO,2N00S2UMMARY Study Interval: Day 87
MMSeEaxlTe HODS:
Indirect Ophthalmoscopy following 1% Tropicamide mydriasis
mGIroup#
A65n4i9m25al#
Observation . Food retinal degeneration OD
654932 Focal retinal degeneration OS
Female n
665545906752
Focal retina] degeneration OS Focal retinal degeneration OD
COMMENTS/DISCUSSION Four (4) animals were identified with ophthalmoscopic lesions, three (3) males and one
(1) female. In all three males, the retinal changes can be attributed to trauma to the globe and/or orbit during orbital sinus bleeding. In the female, it is considered to be an incidental finding.
No compound related ocular abnormalities were identified.
-479-
Company Sanitized. Does not contain TSCA CBI
Company Sanitized. Does not contain TSCA CBI
^^M JB B U ^B H H H S ub chronic Toxicity 90-Day Oral Gavage Study in Rats
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation
MI
654928 No Ophthalmological Abnormalities Detected
MI
654993 No Ophthalmological Abnormalities Detected
MI
654929 No Ophthalmologi cal Abnormalities Detected
MI
654972 No Ophthalmological Abnormalities Detected
MX
654950 No Ophthalmological Abnormalities Detected
M .1
654953 No Ophthalmological Abnormalities Detected
MI
654925 Retina, Retinal Degeneration Focal, Right
MI
654987 No Ophthalmological Abnormalities Detected
MI
654903 No Ophthalmological Abnormalities Detected
MX
654994 No Ophthalmological Abnormalities Detected
MI
654949 No Ophthalmological Abnormalities Detected
MI
654992 NO Ophthalmological Abnormalities Detected
MX
654909 No Ophthalmological Abnormalities Detected
MX
654924 No Ophthalmological Abnormalities Detected
MI
654943 No Ophthalmological Abnormalities Detected
MI
654915 NO Ophthalmological Abnormalities Detected
MI
654927 No Ophthalmological Abnormalities Detected
,M I
654956 NO Ophthalmological Abnormalities Detected
MI
654910 No Ophthalmological Abnormalities Detected
MI
654936 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
87 87
-480-
)
DuPont-9478
90-Day Oral Gavage StusduybcinhRroantsi_c__T_o_x_i_c_it_y
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal
M III 654913
M III 654947
M III 654995
M III 654938
M III 654941
M III 654946
M III
654960
M III 654908
M III 654984
M III 654932
Observation No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected o Ophthalmological Abnormali ties Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected Retina, Retinal Degeneration Focal, Left
Days 87 87 87 87 87 87 87 87 87 87
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-481 -
90-Day Oral Gavage StuJSdyubinchRraotnsic Toxicity
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation
MV
655005 No Ophthalmological Abnormalities Detected
V 654907 No Ophthalmological Abnormalities Detected
MV
654980 No Ophthalmological Abnormalities Detected
MV
654959 No Ophthalmological Abnormalities Detected
MV
654961 No Ophthalmological Abnormalities Detected
M V.
654916 No Ophthalmological Abnormalities Detected
MV
654911 Retina, Retinal Degeneration. Focal, Left
MV
654917 No Ophthalmological Abnormalities Detected
MV
654998 No Ophthalmological Abnormalities Detected
MV
654967 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-482-
tt9t0a-^DfalyllOBraHl GNaBvaMge SStuudbyc ihnrRoantsic Toxicity
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animai Observation
M VII 655001 No Ophthalmological Abnormalities Detected
M VII
654975 No Ophthalmological Abnormalities Detected
M VII 654922 No Ophthalmological Abnormalities Detected
M VII
654940 No Ophthalmological Abnormalities Detected
M VII
654930 No Ophthalmological Abnormalities Detected
M VII 654958 No Ophthalmological Abnormalities Detected
M VII
654952 No Ophthalmological Abnormalities Detected
M VII
654923 No Ophthalmological Abnormalities Detected
M VII
654989 No Ophthalmological Abnormalities Detected
M VII
655006 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87
>
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-483-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation
M IX
654983 NO Ophthalmological Abnormalities Detected
M IX
654965 Globe, Phthisis bulbi, Right
.M IX
654979 No Ophthalmological Abnormalities Detected
M IX
654986 No Ophthalmological Abnormalities Detected
M IX
655003 No Ophthalmological Abnormalities Detected
M IX
654921 No Ophthalmological Abnormali ties Detected
M IX
654996 No Ophthalmological Abnormalities Detected
M IX
654951 No Ophthalmological Abnormalities Detected
M IX
654955 No Ophthalmological Abnormalities Detected
M IX
654914 No Ophthalmological Abnormalities Detected
M IX
654985 No Ophthalmological Abnormalities Detected
M IX
654978 No Ophthalmological Abnormalities Detected
M IX
654974 No Ophthalmological Abnormalities Detected
M IX
654990 No Ophthalmological Abnormalities Detected
M IX
654976 No Ophthalmological Abnormalities Detected
M IX
654957 No Ophthalmological Abnormalities Detected
M IX
654973 No Ophthalmological Abnormalities Detected
M IX
654977 No Ophthalmological Abnormalities Detected
M IX M IX
654942 654991
No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
87 87 87
-484-
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
l90-Day Oral Gavage Stud[SyuibncRhraotnsic Toxicity
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation
F II
655031 No Ophthalmological Abnormalities Detected
F II
655107 No Ophthalmological Abnormalities Detected
F II
655098 No Ophthalmological Abnormalities Detected
F II
655016 No Ophthalmological Abnormalities Detected
F II
655079 No Ophthalmological Abnormalities Detected
F II
655036 No Ophthalmological Abnormalities Detected
F II
655025 No Ophthalmological Abnormali ties Detected
F II
655099 No Ophthalmological Abnormalities Detected
F II
655032 No Ophthalmological Abnormalities Detected
F II
655083 No Ophthalmological Abnormalities Detected
F II
655035 No Ophthalmological Abnormalities Detected
F II
655009 No Ophthalmological Abnormalities Detected
F I
655068 No Ophthlmological Abnormalities Detected
F II
655019 No Ophthalmological Abnormalities Detected
F II
655062 No Ophthalmological Abnormalities Detected
F II
655109 No Ophthalmological Abnormalities Detected
F II
655101 NO Ophthalmological Abnormalities Detected
F II
655072 Retina, Retinal Degeneration Focal, Right
F II
655015 No Ophthalmological Abnormalities Detected
F II
6,55071 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
87 87
-485-
)
DuPont-9478
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
INDIVIDUAL OPHTHALMOLOGICL OBSERVATIONS (Test Day 87)
Sex Group Animal
F IV
655086
F IV
655041
F IV
655108
F IV
655040
F IV
655044
F IV
655013
F IV
655089
F IV
655091
F IV
655033
F IV
655090
Observation No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-486-
90-Day Oral Gavage SJtu^SdyubinchRraotnsic Toxicity
)
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation
F VI' ' 655054 No Ophthalmological Abnormalities Detected
F VI
655038 No Ophthalmological Abnormalities Detected
F VI
655034 No Ophthalmological Abnormalities Detected
F VI
655039 No Ophthalmological Abnormalities Detected
F VI
655029 No Ophthalmological Abnormalities Detected
F VI
655067 No Ophthalmological Abnormalities Detected
F VI
655020 No Ophthalmological Abnormalities Detected
F VI
655087 No Ophthalmological Abnormalities Detected
F VI
655066 No Ophthalmological Abnormalities Detected
F VI
655042 No Ophthalmological Abnormalities Detected
,
Days 87 87 87 87 87 87 87 87 87 87
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-487-
[Subchronic Toxicity 90-Day Oral Gavage Study in Rats
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animal Observation F VIII 655058 No Ophthalmological Abnormalities Detected F VIII 655076 No Ophthalmological Abnormalities Detected F VIII 655047 No Ophthalmological Abnormalities Detected F VIII 655055 No Ophthalmological Abnormalities Detected F VIII 655105 No Ophthalmological Abnormalities Detected F VIII 655078 No Ophthalmological Abnormalities Detected F VIII 655073 No Ophthalmological Abnormalities Detected F VIII 655011 NO Ophthalmological Abnormalities Detected F VIII 655085 No Ophthalmological Abnormalities Detected F VIII 655012 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-488-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
INDIVIDUAL OPHTHALMOLOGICAL OBSERVATIONS (Test Day 87)
Sex Group Animai Observation
FX
655097 No Ophthalmological Abnormalities Detected
FX
655052 No Ophthalmological Abnormalities Detected
FX
655063 No Ophthalmological Abnormalities Detected
FX
655103 No Ophthalmological Abnormalities Detected
FX
655026 No Ophthalmological Abnormalities Detected
FX
655095 No Ophthalmological Abnormalities Detected
FX
655023 No Ophthalmological Abnormalities Detected
FX
655007 No Ophthalmological Abnormalities Detected
FX
655053 No Ophthalmological Abnormalities Detected
FX
655092 No Ophthalmological Abnormalities Detected
FX
655037 No Ophthalmological Abnormalities Detected
FX
655088 No Ophthalmological Abnormalities Detected
FX
655010 No Ophthalmological Abnormalities Detected
FX
655077 No Ophthalmological Abnormalities Detected
FX
655030 No Ophthalmological Abnormalities Detected
FX
655075 No Ophthalmological Abnormalities Detected
FX
655100 No Ophthalmological Abnormalities Detected
FX
655049 No Ophthalmological Abnormalities Detected
F X.
655084 No Ophthalmological Abnormalities Detected
FX
655061 No Ophthalmological Abnormalities Detected
Days 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87 87
-489-
DuPont-9478
ISubchronic Toxicity "90-Day Oral Gavage Study in Rats
DuPont-9478
APPENDIX G INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
490-
Company Sanitized. Does not c o n ta in TSCA CBI
,,90_-_D_a_y__O)_r_a_l_G__a_v_a_g_e_SStuubdcyhirnonRicatTs oxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group I Omg/kg/day
BASELINE
NAunmimbaelr 654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
Forelimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.63 0.53 0.46
0.54
0.66 0.62 0.62
0.63
0.46 0.65 0.65
0.59
0.46 0.53 0.58
0.52
0.56 0.52 0.40
0.49
0.51 0.66 0.66
0.61
0.41 0.41 0.32
0.38
0.49 0.40 0.41
0.43
0.72 0.61 0.52
0.62
0.41 0.56 0.45
0.47
Hindlimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.26 0.38 0.41
0.35
0.48 0.41 0.27
0.39
0.24 0.27
0.29
0.27
0.27 0.38 0.22
0.29
0.23 0.22 0.23
0.23
0.48 0.29 0.27
0.35
0.31 0.40 0.35
0.35
0.22 0.31 0.23
0.25
0.39 0.26 0.38
0.34
0.23 0.22 0.20
0.22
Company Sanitized. Does not contain TSCA CBI
491-
m90-D- ayJO--ral Gavage StpujdsyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group III 1mg/kg/day
BASELINE
NAunmimbaelr 654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
Trial 1 0.77 ' 0.57 0.47 0.42 0.70 0-52 0.62 0.80 0.64 0.61
Forelimb Grip Strength (kat
Trial 2 Trial 3 ThMreeeaTnroiafls
0.46 0.56
0.60
0.37 0.54
0.49
0.58 0.69
0.58
0.40 0.36
0.39
0.46 0.45
0.54
0.39 0.60
0.50
0.74 ' 0.64
0.67
0.76 0.72
0.76
0.72 0.82
0.73
0.48 0.63
0.57
Hindlimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.28 0.27 0.36
0.30
0.26 0.25
0.36
0.29
0.32 0.20 0.21
0.24
0.19 0.27 0.25
0.24
0.46 0.36 0.23
0.35
0.40 0.43
0.42
0.42
0.31 0.38
0.28
0.32
0.38 0.37 0.30
0.35
0.28 0.18 0.26
0.24
0.47 0.33 0.29
0.36
Company Sanitized. Does not contain TSCA CBI
492-
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group V 5 mg/kg/day
BASELINE
NAunmimbaelr 654911 654916 654917 654959 654961 654967 654998 654907 654980 655005
Trial 1 0.68 0.56 0.61 0.56 0.76 0.56 0.45 0.52 0.61 0.76
Forelimb Grip Strength (kg)
Trial 2 Trial 3 ThMreeeanTroiafls
0.85 0.71. 0.75
0.42 0.58
0.52
0.59 0.56
0.59
0.64 0.48
0.56
0.85 0.69
0.77
0.56 0.45
0.52
0.53 0.52
0.50
0.37 0.38
0.42
0.44 0.42
0.49
0.53 0.56
0.62
Hindlimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
0.23 0.27 0.32
0.27
0.29 0.25 0.26
0.27
0.36 0.24 0.22
0.27
0.34 0.31
0.30
0.32
0.35 0.27 0.30
0.31
0.22 0.18 0.20
0.20
0.23 0.22 0.22
0.22
0.35 0.47 0.28
0.37
0.23 0.25 0.28
0.25
0.20 0.46 0.28
0.31
Company Sanitized. Does not contain TSCA C8I
493-
90-Day
)
Oral
Gavage
StuJdSyubinchRroantsic,
Toxicity
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group VII 25 mg/kg/day
BASELINE
NAunmimbaelr 654922 654923
654952 654958
654975 654989 655001 655006 654930 654940
Forelimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.70 0.45 0.61
0.59
0.53 0.64 0.76
0.64
0.72 0.85 1.01
0.86
0.61 0.56 0.48
0.55
0.54 0.55 0.49
0.53
0.45 0.66 0.51
0.54
0.44 0.58 0.56
0.53
0.47 0.49 0.56
0.51
0.54 0.53 0.51
0.53
0.69 0.71 0.65
0.68
Hindlimb Grip Strength (ke)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.32 0.32 0.30
0.31
0.19 0.20 0.23
0.21
0.29 0.35
0.41
0.35
0.45 0.25
0.31
0.34
0.36 0.20 0.29
0.28
0.31 0.25 0.21
0.26
0.21 0.22 0.31
0.25
0.26 0.20 0.24
0.23
0.29 0.22 0.25
0.25
0.34 0.49 0.33
0.39
Company Sanitized. Does not contain TSCA CBI
494-
__90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group IX 125 mg/kg/day
BASELINE
NAunmimbaelr 654942 654957 654973 654974 654976. 654977 654978 654985 654990 654991
Forelimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
0.67 0.48 0.59
0.58
0.60 0.57 0.76
0.64
0.91 0.72 0.75
0.79
0.60 0.61 0.66
0.62
0.35 0.28 0.63. 0.42
0.57 0.69 0.61
0.62
0.41 0.36 0.47
0.41
0.67 0.73 0.53
0.64
0.40 0.60 0.50
0.50
0.51 0.50 0.65
0.55
Hindlimb Grip Strength ike)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.19 0.18
0.19
0.19
0.65 0.37
0.34
0.45
0.34 0.26
0.22
0.27
0.29 0.38 0.26
0.31
0.26 0.20
0.30
0.25
0.23 0.19
0.28
0,23
0.33 0.18
0.20
0.24
0.31 0.22 0.28
0.27
0.30 0.35
0.25
0.30
0.25 0.18 0.19
0.21
Company Sanitized. Does not contain TSCA CBI
-495-
)
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group I 0 mg/kg/day
WEEK 13
NAunmimbaelr 654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
Forelimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
1.85 1.55 1.19
1.53
1.58 1.37 1.20
1.38
1.46 0.75 0.84
1.02
1.31 1.76 1.40
1.49
0.97 1.16 1.11
1.08
0.85 1.32 0.94
1.04
1.52 1.31 1.19
1.34
0.59 1.07 1.02 0.89
1.08 1.06 1.00
1.05
0.59 0.46 0.52
0.52
Hindlimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.46 0.47 0.61
0.51
0.66 0.69 0.55
0.63
0.34 0.38
0.44
0.39
0.73 0.63
0.61
0.66
0.67 0.74 0.58
0.66
0.46 0.38 0.41
0.42
0.30 0.53
0.51
0.45
0.39 0.29 0.44
0.37
0.79 0.95 0.65
0.80
0.34 0.53
0.22
0.36
Company Sanitized. Does not contain TSCA CBI
496-
5ubchronic Toxicity 90-Day Oral Gavage Study in Rats
)
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group HI 1mg/kg/day
WEEK 13
Forelimb Grip Strength (kg')
Hindlimb Grin Strength (kg)
NAunmimbaelr
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
654908
1.47 1.01 1.19
1.22
0.66 0.54 0.75
0.65
654913 ' 1.35 0.75 0.75
0.95
0.22 0.42
0.41
0.35
654932
0.77 1.34 1.45
1.19
0.61 0.76 0.66
0.68
654938
0.78 1.12 1.07
0.99
0.77 0.51
0.47
0.58
654941
0.97 L00 0.97
0.98
0.63 0.58 0.55
0.59
654946
0.95 1.07 1.23
1.08
0.49 0.59
0.48
0.52
654947
0.95 1.28 1.05
1.09
0.52 0.36 0.37
0.42
654960
1.52 0.96 1.46
1.31
0.51 0.67 0.65
0.61
%
654984
L52 1.09 1.58
1.40
0.58 0.71
0.65
0.65
654995
1.43 1.59 1.28
1.43
0.85 0.71
0.72
0.76
Company Sanitized. Does not contain TSCA CBI
497-
'90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
>
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group V 5 mg/kg/day
WEEK 13
NAunmimbaelr 654911 654916 654917 654959 654961 654967 654998 654907 654980 655005
Trial 1 1.06 ' 0.92 1.52 0.96 1.56 1.06 1.07 1.44 1.15 1.60
Forelimb Grip Strength (kg')
Trial 2 Trial 3 ThMreeeanTroiafls
1.59 1.22
1.29
1.14 0.87
0.98
1.03 1.48
1.34
1.25 1.67
1.29
1.80 1.03
1.46
1.27 0.94
1.09
1.09 0.95
1.04
1.11 1.19
1.25
0.72 0.81
0.89
1.55 1.41
1.52
Hindlimb Grin Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.62 0.67
0.56
0.62
0.38 0.51
0.53
0.47
0.54 0.39 0.49
0.47
0.58 0.74 0.42
0.58
0.66 0.62
0.71
0.66'
0.57 0.61
0.50
0.56
0.33 0.31
0.42
.35
0.45 0.33 0.51
0.43
0.55 0.53 0.41
0.50
0.59 0.74 0.59
0.64
Company Sanitized. Does not contain TSCA CBI
498-
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group VII 25 mg/kg/day
WEEK 13
NAunmimbaelr 654922 654923 654952 654958 654975 654989 655001 655006 654930 654940
Trial 1 1.01 1.27 1.45 0.95 1.67 0.99 1.29 0.96 1.27 1.51
Forelimb Grip Strength (kg)
Trial 2 Trial 3 ThMreeeanTroiafls
1.33 0.85
1.06
1.09 1.64
1.33
1.67 1.24
1.45
1.20 0.71
0.95
1.62 1.19
1.49
1.38 1.18
1.18
1.25 1.50
1.35
0.95 1.56
1.16
1.44 0.98
1.23
1.38 1.49
1.46
\
Hindlimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.40 0.46
0.54
0.47
0.63 0.71
0.68
0.67
0.84 0.56 0.57
0.66
0.60 0.51
0.46
0.52
0.63 0.57
0.85
0.68
0.51 0.65
0.69
0.62
0.31 0.43
0.31
0.35
0.35 0.31
0.41
0.36
0.51 0.65
0.55
0.57
0.81 0.90 0.85
0.85
Company Sanitized. Does not contain TSCA CBt
499-
tH B M flH H ^H H H (JSubchronic Toxicity 90-Day Oral Gavage Study in Rats
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Male Rats/Group IX 125 mg/kg/day
WEEK 13
NAunmimbaelr 654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
Trial 1 1.56 ' 1.24 1.30 1.16 1.36 0.66 1.00 0.57 0.75 1.23
Forelimb Grip Strength (kg)
Trial 2 Trial 3 ThMreeeanTroiafls
1.18 1.51
1.42
1.32 1.33
1.30
1.73 1.41
1.48
1.32 1.04
1.17
1.55 1.22
1.38
1.03 0.66
0.78
1.29 1.31
1.20
0.46 0.72
0.58
0.99 1.13
0.96
1.31 0.88
1.14
Hindlimb Grin Strength fke)
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
0.46 0.51
0.42
0.46
0.95 0.61
0.64
0.73
0.59 0.56 0.56
0.57
0.42 0.40 0.42
0.41
0.65 0.49 0.49
0.54
0.31 0.25
0.31
0.29
0.48 0.47
0.44
0.46
0.35 0.19
0.27
0.27
0.44 0.62 0.61
0.56
0.40 0.65 , 0.82
0.62
Company Sanitized. Does not contain TSCA CBI
-500-
90-Day Oral Gavage iudSyuibnchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group II 0 mg/kg/day
BASELINE
NAunmimbaelr 655019 655071 655062 655068 655009 655015 655035 655072 655101 655109
Trial 1 0.65 - 0.73 0.44 0.45 0.51 0.72 0.47 0.60 0.54 0.54
Forelimb Grip Strength (kel
Trial 2 Trial 3 ThMreeeaTnroiafls
0.41 0.63
0.56
0.76 0.67
0.72
0.41 0.55
0.47
0.54 0.48
0.49
0.43 0.67
0.54
0.57 0.50
0.60
0.56 0.40
0.48
0.67 0.51
0.59
0.62 0.79
0.65
0.50 0.59
0.54
Hindlimb Grip Strength (kg!
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.69 0.35
0.43
0.49
0.45 0.36 0.36
0.39
0.37 0.25 0.31
0.31
0.29 0.29 0.37
0.32
0.27 0.34 0.35
0.32
0.33 0.27 0.27
0.29
0.36 0.32 0.33
0.34
0.39 0.38 0.20
0.32
0.46 0.53 0.47
0.49
0.42 0.42 0.40
0.41
Company Sanitized. Does not contain TSCA CB1
-501-
_9__0_-D__ay Oral Gavage StudSyuibnchRraotnsic Toxicity
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group IV 1mg/kg/day
BASELINE
NAunmimbaelr 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
Trial 1 0.74 ' 0.60 0.71 0.61 0.59 0.57 0.73 0.66 0.73 0.44
Forelimb Grip Strength (kg)
Trial 2 Trial 3 ThMreeeanTroiafls
0.66 0.76
0.72
0.51 0.46
0.52
0.57 0.45
0.58
0.75 0,77
0.71
0.56 0.50
0.55
0.70 0.52
0.60
0.69 0.57
0.66
0.72 0.77
0.72
0.73 0.72
0.73
0.55 0.56
0.52
Hindlimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.39 0.46 0.31
0.39
0.50 0.28 0.24
0.34
0.31 0.28 0.26
0.28
0.35 0.34 0.28
0.32
0.32 0.34 0.31
0.32
0.22 0.32 0.44
0.33
0.45 0.42 0.35
0.41
0.32 0.29 0.30
0.30
0.34 0.49 0.51
0.45
0.41 0.32 0.29
0.34
Company Sanitized. Does not contain TSCA CBI
-502-
90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group VI 5 mg/kg/day
BASELINE
NAunmimbaelr 655020 655029 655034 655039 655042 655066 655067 655087 655038 655054
Forelimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.61 0.63 0.44 0.56
0.43 0.64 0.43
0.50
0.58 0.71 0.70
0.66
0.66 0.75 0.85
0.75
0.66 0.76 0.55
0.66
0.70 0.51 0.62
0.61
0.57 0.65 0.57
0.60
0.61 0.91 0.73
0.75
0.73 0.57 0.59
0.63
0.78 0.93 0.68
0.80
Hindlimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.34 0.24' 0.39
0.32
0.43 0.44 0.31
0.39
0.42 0.38 0.33
0.38
0.34 0.44 0.28
0.35
0.27 0.41 0.32
0.33
0.42 0.28
0.26
0.32
0.39 0.36 0.32
0.36
0.31 0.36 0.36
0.34
0.51 0.30 0.39
0.40
0.33 0.49 0.26
0.36
Company Sanitized. Does not contain TSCA CBI
-503-
' 90-D_ay Oral Gavage SJtuSduybicnhRroantsic Toxicity
)
DuPont-9478
INDIVIDUALFORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group VIII 25 mg/kg/day
BASELINE
NAunmimbaelr 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
Trial 1 0.90 0.80 0.59 0.66 0.56 0.45 0.56 0.62 0.59 0.44
Forelimb Grip Strength (ka)
Trial 2 Trial 3 ThMreeeaTnroiafls
0.72 0.56
0.73
0.62 0.66
0.69
0.49 0.65
0.58
0.57 0.48
0.57
0.79 0.65
0.67
0.38 0.58
0.47
0.66 0.75
0.66
0.61 0.53
0.59
0.44 0.79
0.61
0.49 0.44
0.46
Hindlimb Grin Strength fkel
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
0.50 0.43 0.51
0.48
0.44 0.40 0.41
0.42
0.22 0.26 0.26
0,25
0.36 0.37 0.26
0.33
0.23 0.31 0.32
0.29
0.36 0.31 0.34
0.34
0.47 0.34 0.35
0.39
0.58 0.41
0.42
0.47
0.31 0.36 0.28
0.32
0.28 0.20 0.22
0.23
Company Sanitized. Does not contain TSCA CBi
-504-
'90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group X 125mg/kg/day
BASELINE
NAunmimbaelr 655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
Trial 1 0.42 ' 0.58 0.61 0.54 0.67 0.69 0.80 0.59 0.71 0.71
Forelimb.Grip.Strength (kg)
Trial 2 Trial 3 ThMreeeanTroiafls
0.50 0.51
0.48
0.65 0.51
0.58
0.41 0.46
0.49
0.66 0.36
0.52
0.46 0.48
0.54
0.69 0.75
0.71
0.68 0.72
0.73
0.66 0.53
0.59
0.58 0.45
0.58
0.72 0.75
0.73
Hindlimh Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.23 0.29 0.25
0.26
0.40 0.44
0.38
0.41
0.31 0.29 0.28
0.29
0.28 0.27 0.41
0.32
0.35 0.44 0.41
0.40
0.38 0.34 0.32
0.35
0.20 0.22 0.41
0.28
0.26 0.34
0.33 0.31
0.27 0.31
0.21
0.26
0.45 0.38 0.45
0.427
Company Sanitized. Does not contain TSCA CBi
-505-
O 9^0M-DHayHOrHalHGaHvaSgeI ^Sutubdyc binrRoantsic Toxicity
)
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group II 0 mg/kg/day
WEEK 13
Forelimb Grip Strength (kg)
NAunmimbaelr
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
655019
1.02 0.88 0,74
0.88
655071 1
655062
1.04 0;76 0.80
0.87
655068
0.85 0.53 0.58
0.65
655009
1.24 0.94 0,82
1.00
655015
0.99 0.70 0.76
0.82
655035
1.23 1.23 1.13
1.20
655072
1.21 1.34 0.96
1.17
655101
0.74 0.75 0.78
0.76
655109
0.62 0.53 0.66
0.60
Hinrilimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.56 0.70 0.76
0.67
0.47 0.49 0.45
0.38 0.28 0.36
0.54 0.51
0.49
0.41 0.69 0.45
0.49 0.44 0.68
0.33 0.57 0.52
0.61 0.59 0.67
0.38 0.45 0.36
0.47 0.34 0.51 0.52 0.54 0.47 0.62 0.40
Company Sanitized. Does not contain TSCA
iRat accidentally killed on test day 19.
O03
J H H H H H H ^ ^ u b c h ro n ic Toxicity W-Day Oral Gavage Study in Rats
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group IV 1mg/kg/day
WEEK 13
NAunmimbaelr 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
Forelimb Grip Strength (ke)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
1.23 1.10 0.81
1.05
0.57 1.10 1.09
0.92
1.20 0.99 0.53
0.91
0.84 1.36 0.96
1.05
1.40 1.05 1.10
1.18
0.71 0.61 0.50
0.61
1.21 1.05 1.14
1.13
1.22 1.10 0.97
1.10
0.97 1.55 1.46
1.33
1.16 0.83 1.01
1.00
Hindlimb Grip Strength (kel
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.51 0.52 0.51
0.51
0.34 0.45 0.29
0.36
0.45 0.37 0.40
0.41
0.35 0.60 0.31
0.42
0.35 0.41 0.32
0.36
0.31 0.22 0.29
0.27
0.43 0.47 0.48
0.46
0.26 0.27 0.39
0.31
0.61 0.56 0.57
0.58
0.24 0.38 0.46
0.36
Company Sanitized. Does not contain TSCA CBI
-507-
90-Day Oral Gavage tdyubinchRraotnsie Toxicity
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group VI 5 mg/kg/day
WEEK 13
NAunmimbaelr 655020 655029 655034 655039 655042 655066 655067 655087 655038 655054
Forelimb,Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
1.29 0.64 1.07
1.00
1.05 1.30 0.92 1.05 0.84 0.80 1.42 ,1.12 1.36 0.95 0.89 1.20
1.09 0.90 1.30 1.01
1.19 0.98 1.24
1.14
1.12 0.88 0.84
0.95
0.73 0.92 0.98
0.88
1.27 1.18 1.42
1.29
0.83 1.08 0.88
0.93
Hindlimb Grin Strength fort
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.55 0.60
0.54
0.56
0.46 0.53
0.68
0.56
0.44 0.48
0.48
0.47
0.62 0.61
0.46
0.56
0.70 0.45
0.44
0.53
0.73 0.54 0.43
0.57
0.29 0.48
0.41
0.39
0.34 0.37 0.41
0.37
0.47 0.62
0.56
0.55
0.30 0.39
0.30
0.33
Company Sanitized. Does not contain TSCA CBI
-508-
*90-Day Oral Gavage StuIdSyubinchRraotns_ic__T_o_x_i_c_it_y
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group VIII 25 mg/kg/day
WEEK 13
NAunmimbaelr 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
Foreiimb Grip Strength (kg)
Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls
1.18 1.23 1.34
1.25
1.21 0.82 1.00
1.01
1.19 1.13 0.96
1.09
1.00 1.10 0.90
1.00
0.99 1.26 1.52
1.26
0.72 0.77 0.66
0.72
0.71 0.92 0.78
0.80
1.24 1.19 0.95
1.13
0.88 0.63 0.90
0.80
0.77 0.96 0.79
0.84
Hindlimb Grip Strength (kg')
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.75 0.84 0.73
0.77
0.39 0.42 0.41
0.41
0.28 0.30 0.37
0.32
0.58 0.43 0.46
0.49
0.34 0.33 0.35
0.34
0.50 0.42
0.39
0.44
0.59 0.45
0.56
0.53
0.65 0.61
0.50
0.59
0.28 0.41
0.54
0.41
0.42 0.46 0.36
0.41
Company Sanitized. Does not contain TSCA
O03
90-Day Oral Gavage Stu|SdyubinchRroatnsic Toxicity
')
)
DuPont-9478
INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH
Female Rats/Group X 125 mg/kg/day
WEEK 13
NAunmimbaelr 655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
Forelimb Grin Strength (kel
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.96 0.65 0.68
0.76
1.08 1.06 0.81
0.98
0.96 1.15 0.94
1.02
1.03 1.19 1.13
1.12
1.10 0.76 1.05
0.97
0.95 0.81 0.80
0.85
1.15 0.88 0.91
0.98
1.01 0.94 1.46
1.14
0.88 0.84 0.63
0.78
0.85 1.24 1.11
1.07
Hindlimb Grip Strength fkg)
Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls
0.33 0.34 0.56
0.41
0.59 0.51 0.49
0.53
0.46 0.52 0.55
0.51
0.44 0.55
0.38
0.46
0.52 0.56 0.41
0.50
0.61 0.46 0.47
0.51
0.44 0.43
0.31
0.39
0.57 0.45 0.41
0.48
0.31 0.33 0.28
0.31
0.65 0.45 0.46 . 0.52
Company Sanitized. Does not contain TSCA CBI
-510-
ISubchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-9478
APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT
-511-
Company Sanitized. Does not contain TSCA CBI
f9e0j-|DBa^yfOlHraBl GiHavHagHe0SStuudbycinh rRoantsic Toxicity INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT
Male Rats/Group I: 0 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
ANNUMIMBAELR
ASSESSMENT PERIOD
APPROACH & TOUCH
654909 Baseline
0
Week 13
0
654910 Baseline
0
Week 13
0
654915 Baseline
0
Week 13
0
654924 Baseline
0
Week 13
0
654927
654943 654949 654956 654992 654994
Baseline
Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13
0
0 0 0 0 0 0 0 0 0 0 0
AUDITORY STIMULUS
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
PRUEPSIPLOLANRSEY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 1 0 0 1 0 1 0 1 1 1 0 0 1 1 0 0 0 0 1
URINATION 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1 1 0 1 1
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-512-
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
Male Rats/Group III: 1 mg/kg/day
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT
MANIPULATIONS
MOTOR ACTIVITY
ANNUIMMBAELR
APESRSEIOSDSMENT
APPROACH & TOUCH
654908 Baseline
0
Week 13
0
654913 Baseline
0
Week 13
0
654932 Baseline
0
Week 13
0
654938 Baseline
0
Week 13
0
654941 Baseline
0
Week 13
0
654946 Baseline
0
Week 13
0
654947 Baseline
1
Week 13
0
654960 Baseline
0
Week 13
0
654984 Baseline
0
Week 13
0
654995 Baseline
0
Week 13
0
ASTUIDMITUOLRUYS 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
PRUEPSIPLOLANRSEY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 1 0 1 0 1 0 1 0 1 0 0 0 1 1 1 0 0 1 0
URINATION 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 0 1 1
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-513-
90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity
Maie Rats/Group V: 5 mg/kg/day
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT
MANIPULATIONS
MOTOR ACTIVITY
ANIMAL NUMBER
PAESRSIEOSDSMENT
APPROACH TOUCH
&
654911 Baseline
0
Week 13
0
654916 Baseline
0
Week 13
'0
654917 Baseline
0
Week 13
0
654959 Baseline
0
Week 13
0
654961 Baseline
0
Week 13
0
654967 Baseline
0
Week 13
0
654998 Baseline
0
Week 13
0
654907 Baseline
0
Week 13
0
654980 Baseline
0
Week 13
0
655005 Baseline
0
Week 13
0
ASTUIDMIUTOLURYS 0 0 0 0 0 0 0 0, 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PRUEPSIPLOLNASREY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 0 0 1 0 1 1 1 0 0 1 1 0 1 0 1 0 1 o 1 1
URINATION 1 1 1 1 1 1 1 0 1 1 1 1 1 1 1 1 1 1 1 1
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
-514-
"90-Day Oral GaVage StudSyuibncRhraotnsic Toxicity
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group VII: 25 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
ANNUMIMBAELR
ASSESSMENT PERIOD
APPROACH & TOUCH
654922 Baseline
0
Week 13
0
654923 Baseline
0
Week 13
0
654952 Baseline
0
Week 13
0
654958 Baseline
0
Week 13
0
654975 Baseline
0
Week 13
0
654989 Baseline
0
Week 13
0
655001 Baseline
0
Week 13
0
655006 Baseline
0
Week 13
0
654930 Baseline
0
Week 13
0
654940 Baseline
0
Week 13
0
AUDITORY STIMULUS
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PUPILLARY RESPONSE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 0 0 0 0 0 1 0 0 1 0 0 1 1 0 0 0 0 0 1
URINATION 1 1 1 0 1 1 1 1 1 1 1 1 1 0 1 0 1 1 1 1
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-515-
90-Day Oral Gavage SuIdSyubinchRraotnsic Toxicity
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group IX: 125 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
NAUNIMMBAELR
PAESRSIEOSDSMENT
APPROACH & TOUCH
654942 Baseline
0
Week 13
0
654957 Baseline
0
Week 13
'0
654973 Baseline
0
Week 13
0
654974 Baseline
0
Week 13
0
654976 Baseline
0
Week 13
0
654977 Baseline
0
Week 13
0
654978 Baseline
0
Week 13
0
654985 Baseline
0
Week 13
0
654990 Baseline
0
Week 13
0
654991 Baseline
0
Week 13
0
AUDITORY STIMULUS
0 .0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PRUEPSIPLOLNASREY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 o0 0 0 0
DEFECATION 0 0 1 0 1 1 1 0 0 0 0 0 0 1 1 1 0 1 0 0
URINATION 1 1 1 0 0 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-516-
Company Sanitized. Does not contain TSCA CBI
^ 90-D^ay OralGav ageRSStuiidbycihnfRoattisic Toxicity
)
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group II: 0 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
ANNUIMMBAELR
PAESRSIEOSDSMENT
APPROACH & TOUCH
655019 Baseline
0
Week 13
0
655071 Baseline
0
Week 13a
655062 Baseline
0
Week 13
0
655068 Baseline
0
Week 13
0
655009 Baseline
0
Week 13
0
655015 Baseline
0
Week 13
0
655035 Baseline
0
Week 13
0
655072 Baseline
0
Week 13
0
655101 Baseline
0
Week 13
0
655109 Baseline
0
Week 13
0
ASTUIDMIUTOLURYS 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PRUEPSIPLOLNASREY 0 0 0
DEFECATION 1 1 0
URINATION 1 0 1
0 11 001 001 001 0 10 0 11 000 001 001 000 001 0 11 001 001 0 11 00 1
aRat accidentally killed on test day 19.
-517-
)
DuPont-9478
'90-Day Oral Gavage SBtu^dSyubinchRraotnsic Toxicity
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group IV: 1 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
ANNUIMMBAELR PAESRSIEOSDSMENT APPTROOUACCHH &
655013 Baseline
0
Week 13
0
655033 Baseline
0
Week 13
0
655040 Baseline
0
Week 13
0
655041 Baseline
0
Week 13
0
655044 Baseline
0
Week 13
0
655086 Baseline
0
Week 13
0
655089 Baseline
0
Week 13
0
655090 Baseline
0
Week 13
0
655091 Baseline
0
Week 13
0
655108 Baseline
0
Week 13
0
ASTUIDMITUOLURYS 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PRUEPSIPLOLNASREY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 0 0 1 0 1 0 1 1 0 0 0 0 1 0 1 1 1 0 1
URINATION 1 1 1 1 1 1 1 1 1, 1 0 1 1 1 1i 1 1 1 1
DuPont-9478
Company Sanitized. Does not contain TSCA C8I
-518-
90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VI: 5 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
ANIMAL ASSESSMENT APPROACH &
NUMBER PERIOD
TOUCH
655020 Baseline
0
Week 13
0
655029 Baseline
0
Week 13
'0
655034 Baseline
0
Week 13
0
655039 Baseline
0
Week 13
0
655042 Baseline
0
Week 13
0
655066 Baseline
0
Week 13
0
655067 Baseline
0
Week 13
0
655087 Baseline
0
Week 13
0
655038 Baseline
0
Week 13
0
655054 Baseline
0
Week 13
0
AUDITORY STIMULUS
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PUPILLARY RESPONSE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 'o 0 0
DEFECATION 1 0 0 1 1 0 1 1 0 1 1 1 1 1 1 0 1 1 0 1
URINATION 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1
)
i
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-519-
|jk90. -Day Oral Gavage StudyubinchRraotnsic Toxicity
)
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VIII: 25 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
NAUNMIMBAELR PAESRSIEOSDSMENT APPTROOUACCHH &
655011 Baseline
0
Week 13
0
655012 , Baseline
0
Week 13
0
655047 Baseline
0
Week 13
0
655055 Baseline
0
Week 13
0
655058 Baseline
0
Week 13
0
655073 Baseline
0
Week 13
0
655076 Baseline
0
Week 13
0
655078 Baseline
0
Week 13
0
655085 Baseline
0
Week 13
0
655105 Baseline
0
Week 13
0
ASTUIDMIUTOLURYS 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAIL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
PRUEPSIPLOLNASREY 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 1 0 0 1 1 1 1 0 1 1 0 1 0
,0 0 1 0 0 1
URINATION 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 0 1 1 1 1
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-520-
J t90-DjHayHOHralHGBavHagfeRStuubdyc hinrRoantsic Toxicity
)
INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group X: 125 mg/kg/day
MANIPULATIONS
MOTOR ACTIVITY
NAUNMIMBAELR
PAESRSIEOSDSMENT
APPROACH & TOUCH
655010 Baseline
0
Week 13
0
655030 Baseline
0
Week 13
0
655037 Baseline
0
Week 13
0
655049 Baseline
0
Week 13
0
655061 Baseline
0
Week 13
0
655075 Baseline
0
Week 13
0
655077 Baseline
0
Week 13
0
655084 Baseline
0
Week 13
0
655088 Baseline
0
Week 13
0
655100 Baseline
0
Week 13
0
AUDITORY STIMULUS
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
TAEL PINCH 0 0 0 0 0 0 0 0 0 0 0 0 90 0 0 0 0 0 0
PUPILLARY RESPONSE
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
DEFECATION 1 0 1 1 1 1 1 1 0 0 1 1 1 0 0 0 1 1 1 0
URINATION 1 1 1 1 1 1 1 1 1 P 1 1 0 1 1 1 1 1 1 1
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-521-
Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
APPENDIX I INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
- 522 ' ,
Company Sanitized. Does not contain TSCA CBI
ISubchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline Male Rats/Group I: 0 mg/kg/day
NAunmimbaelr
1
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
395 398 440 359 383 324 396 419 363 350
Successive 10-Minute Intervals
2345
336 162
0 14
273 151
13
389 282
59
1
325 246
22
0
364 35
1 36
247 215 214. 280
288 201
30
3
375 260
66
259 373
99
321 230 112
0 17 0
6 1 10 2 0 12 217 0 12 6 11
Baseline Male Rats/Group III: 1 mg/kg/day
Animal Number
1
Successive 10-Minute Intervals 234S
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
345 270 249 236
4
442 366 384 213
19
423 307 262
40
3
420 397 254 202
6
322 311 195 0 2
377 340 321 364 175
353 280 316 188
13
409 368 394 276 125
396 345 295 23 45
535 457 449
85 439
6 145 12
3 0 0 73 8 0 3 95
Total 908 836 1173 952 831 1497 918 1132 1117 1024
Total 1249 1436 1038 1279 830 1650 1158 1572 1107 2060
-523 -
Company Sanitized. Does not contain TSCA CBi
(9 0-Day Oral Ga vage MSt^uSdyubinchRraotms_c__T_o_x_i_c_it_y__________________________________ ________________DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline Male Rats/Group V: 5 mg/kg/day
NAunmimbaelr 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
Successive 10-Minute Intervals 123456
420 292 160
77
3
3
370 323 211 40 19
0
431 320 356 321 331 266
357 314 168 22 12
4
324 271 243
96
9
4
420 426 387 326 319 279
411 361 267 235 268 129
426 342 284 328
35
7
405 315 216 239 119
6
450 374 247
38
8 21
Baseline Male Rats/Group VU: 25 mg/kg/day
Animal Number
12
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
393 345 384 260 384 233 328 196 405 299 434 295 398 314 399 197 454 392 400 391
Successive 10-Minute Intervals 345
323 344 103
288 216
34
141 0 0
31 3 0
249 231 245
229 270 245
205 35
0
2 20
275 79
2
252 280
48
6 48 2 13 0 181 316 15 5 14 6
Total 955 963 2025 877 947 2157 1671 1422 1300 1138
Total 1556 1184 771 558 1610 1789 967 605 1216 1377
-524-
Company Sanitized. Does not contain TSCA CB)
__ l? | Subchronic Toxicity ^90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline
Male Rats/Group IX: 125 mg/kg/day
NAunmimbaelr
I
2
Successive 10-Minute Intervals 345
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
413 500 415 390 351 337 451 355 416 388
328 471 310 359 265 320 390 233 438 315
72 478 343 257 111 331 317 304 374 227
67 420 226 11
0 334 315 51 119 94
3 231 222
1 0 120 316 4 2 5
6 0 77 220 20 0 40 142 4 1 5
Total 883 2177 1736 1038 727 1482 1931 951 1350 1034
-525-
Company Sanitized. Does not contain TSCA CBI
__ | Subchronic Toxicity ^O-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline Female Rats/Group II: 0 mg/kg/day
NAunmimbaelr
I2
655009 655015 655019 655035 655062 655068 655071 655072 655101 655109
329 155 317 118 324 262 425 377 351 247 407 313 460 443 326 314 338 243 424 178
Successive 10-Minute Intervals 345
279 215 232
2 145 189
261 234 126
283 336
31 .
172 101
2
322 261 198
380 355 400
380 175 208
248 306 188
101 277 314
Baseline
Female Rats/Group IV: 1 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 12345
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
446 365' 305 361 338
363 288 160 187 310
388 312 229
20
8
322 266 337 243 254
361 294 212 174
4
370 216 106 288 130
357 239 191
53 185
336 284 231
81
1
525 482 419 444 484
424 278 254 222 116
6 103 141
4 7 1 155 157 66 217 265
6 339 157
3 66 0 68 158 1 481 176
Total 1313 912 1211 1459 874 1656 2195 1469 1540 1559
Total 2154 1465 960 1488 1045 1178 1183 934 2835 1470
-526-
Company Sanitized. Does not contain TSCA CBI
Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline Female Rats/Group VI: 5 mg/kg/day
NAunmimbaelr 655020 655029 655034 655038
655039
655042 655054 655066 655067 655087
Successive 10-Minute Intervals I 23456
413 63 59 330 290 158
334 233 207 198 1 3
341 322 181 5 6 10
349 289 194 272 152 268
339 350 263 263 38 11
339 307 283 247
40
2
371 269 216 313 299 285
404 344 317 258 247 164
392 410 307 422 237 299
362 239 311 248 231 196
Baseline Female Rats/Group VUI: 25 mg/kg/day
NAunmimbaelr
12
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 ,
301 123 400 290 329 360 394 264 306 198 385 243 384 331 391 91 433 334 410 359
Successive 10-Minute Intervals
3 -4
5
178 i l l
7
291 192 205
262 223 319
191 144
0
97 160 190
196 198 288
307 265 231
192 312
34
290 116 ' 2
340 275 252
6 66 11 98 0 107 175 47 56 1 168
Total 1313 976 865 1524 1264 1218 1753 1734 2067 1587
Total 786 1389 1591 993 1058 1485 1565 1076 1176 1804
-527-
Company Sanitized. Does not contain TSCA CBI
subchronic Toxicity ~90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Baseline
Female Rats/Group X: 125 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 12345
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
392 345 285
77
0
336 285 188 312 263
466 472 428 410 255
423 286 272 271 267
303 283 200 264 205
391 337 353 311 276
274 257 119 36 49
294 285 300 192
43
337 286 266 225 148
453 369 313 266 308
6 0 187 105 246 298 243 0 1 120 246
Total 1099 1571 2136 1765 1553 1911 735 1115 1382 1955
-528 -
Company Sanitized. Does not contain TSCA CBI
| Subchronic Toxicity '90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Male Rats/Group I: Omg/kg/day
NAunmimbaelr
1
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
405 317 417 371 394 411 415 431 358 312
Successive 10-Minute Intervals
2345
324 313 227 249
276 191 215
96
371 259 280 170
315 245 169 196
384 368 318 287
341 283 254 258
333 277 350 213
349 341 321 331
284 268 289 231
295 335 276 229
6 3 27. 185 77 263 254 217 255 128 173
Total 1521 1122 1682 1373 2014 1801 1805 2028 1558 1620
Week 13
Male Rats/Group El: 1 mg/kg/day
NAunmimbaelr
1
Successive 10-Minute Intervals 2 3 -4 5
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995a
386 368 294 273 299
390 365 258 282 274
388 350 343 237 100
428 365 261 302 334
320 281 206 164
24
415 358 344 296 252
381 346 312 283 130
463 346 331 363 291
385 329 307 295 140
518 529 469 441 516
6 Total 200 1820 238 1807 42 1460 180 1870 15 1010 250 1915 50 1502 162 1956 10 1466 459 2932
aData inaccurate due to sensor malfunction; data excluded from summary table and statistical analysis
-529-
Company Sanitized. Does not contain TSCA CB)
____________________ Subchronic Toxicity ~90-Day Oral Gavage Study in Rats_________
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Male Rats/Group V: 5 mg/kg/day
NAunmimbaelr 654911 654916 654917 654959 654961 654967 654998 654907 654980 655005
Successive 10-Minute Intervals
1 2 3 4 5
309 . 446
301 200 360 338
248 226
104 130
414 328 290 273 147
363 278 210 38 55 .
375 332 264 206 203
455 353 220 131 265
385 375 252 166 206
370 264 262 163
3
379 373 191 265 195
401 362 211 371 324
Week 13
Male Rats/Group VII: 25 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 1 23 45
654922 654923 654952 654958 654975 654989 655001 655006 654930 654940
395 320 229 244 188
455 361 138 256
20
399 321 208 114
70
459 381 318 236 232
387 224 162 194
90
398 180
0
2
0
417 295 337 280
94
381 335 272 262 218
433 367 351 186 205'
410 292 264 324 175
6 9 278 9 157 281 144 131 7 5 26
6 236 65 172 186 202
1 113 149 224 230
DuPont-9478
Total 1171 1778 1461 1101 1661 1568 1515 1069 1408 1695
Total 1612 1295 1284 1812 1259 581 1536 1617 1766 1695
-530-
Company Sanitized. Does not contain TSCA CBI
Q H H H H H H H M Q Subchronic Toxicity ^90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Male Rats/Group IX: 125 mg/kg/day
NAunmimbaelr
12
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
290 236 456 372 391 380 339 303 340 232 476 423 472 317 360 252 460 393 466 358
Successive 10-Minute Intervals 34 5
61 21
0
314 348 328
276 276 236
288 151 202
98 21
8
385 379 336
369 378 239
228 243 109
388 232 206
340 155 357
6 119 250 . 170 254
2 317 261
2 119 182
Total 727 2068 1729 1537 701 2316 2036 1194 1798 1858
-531 -
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage Study in Rats__________
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Female Rats/Gxoup II: 0 mg/kg/day
NAunmimbaelr
I2
655019 655071" 655062 655068 655009 655015 655035 655072 655101 655109
368 267
...
390 227 378 244 347 345 342 279 362 283 357 289 406 305 497 365
Successive 10-Minute Intervals 345
237 233 206
210 252 166 236 246 204 292 311 256 140 156 136 238 291 239 258 203 185 231 219 187 292 126 245
6 157
246 247 215 32 201 128 308 281
DuPont-9478
Total 1468 1491 1555 1766 1085 1614 1420 1656 1806
Week 13 Female Rats/Grup IV: 1 mg/kg/day
Animal Number
I2
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
385 272 358 278 375 298 431 306 387 356 367 141 471 259 463 340 477 402 364 289
Successive 10-Minute Intervals 345
256 211 174
139 227
74
317 293 274
206 250 185
282 180 142
195 270 135
221 310 226
364 279 172
261 358 265
215 114 173
6 Total 243 1541 56 1132 319 1876 182 1560 184 1531 34 1142
0 1487 26 1644 281 2044 179 1334
aRat accidentally killed on test day 19.
-532-
Company Sanitized. Does not contain TSCA CBI
pH H B H B H H H H H ^Subchrom c Toxicity 90-Day Oral Gavage Study in Rats_________
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Female Rats/Group VI: 5 mg/kg/day
NAunmimbaelr 655020 655029 655034 655039 655042 655066 655067 655087 655038 655054
Successive 10-Minute Intervals
12 3 4 5
451 307 263 49 10
380 398
349 233
287 142
227 67
223 200
419 356
259 265
102 T57
118 322
38 187
393 381 243 204 180
460 348
332 261
135 172
i02 118
216 218
413 315 318 205 110
458 412 293 251 127
6 229 119
5 191 181 114 284 181 107 292
Week 13
Female Rts/Group VUI: 25 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 1. 2. 3 4 5
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
369 250 175 228
18
447 327 243 210 194
378 290 211 216
15
348 217 171 121 137
284 152 147 144
71
464 352 313 288 201
457 318 321 197 178
415 370 250 103 206
415 332 243 377 191
496 376 266
47 212
6 148 218 142 103 83 260 198 239 113 251
DuPont-9478
Total 1309 1585 1045 1127 1468 1515 1529 1298 1468 1833
Total 1188 1639 1252 1097 881 1878 1669 1583 1671 1648
-533 -
Company Sanitized. Does not contain TSCA C8I
te H H H B M H H d L s u b c h ro m c Toxicity * ^ M ^ ^ U ^ T O a v a g ? ^ d y in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS
Week 13 Female Rats/Group X: 125 mg/kg/day
NAunmimbaelr
12
655010 655030 655037a 655049 655061 655075 655077 655084 655088 655100
381 297 394 295 493 484 396 333 400 204 454 352 381 279 470 326 313 228 439 405
Successive 10-Minute Intervals 345
235 261 177
257 260 201
427 503 408
255 260 188
169 276 190
331 64 291
105 187
49
274 247 351
219 187 135
322 292 272
6 66 202 . 95 129 268 222 ' 1 169 0 321
Total 1417 1609 2410 1561 1507 1714 1002 1837 1082 2051
aData inaccurate due to sensor malfunction; data excluded from summary table and statistical analysis
-534-
Company Sanitized. Does not contain TSCA CBI
Subchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
APPENDIX J INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
-535-
Company Sanitized. Does not contain TSCA CBI
iSubchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline Male Rats/Group I: Omg/kg/day
Animal Number
I
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
132 146 88 146 138 129 137 139 135 159
Successive 10-Minute Intervals
2145
141 86
2 10
165 133 2 5
115 128
42
3
132 143
19
1
148 - 36
1 20
138 145 144 153
141 154
39
7
133 150
58
0
127 124 97 13
146 142 103
2
6 5 10 6 2 9 136 2 16 9 17
Baseline
Male Rats/Group HI: 1 mg/kg/day
NAunmimbaelr
I
Successive 10-Minute Intervals 2345
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
141 135 126 159
9
119 139 139 140
15
146 151 132
38
5
145 145 131 137 119 118
97 1
48
150 133 143 177 158
125 121 131 113
10
130 139 134 143
96
134 146 159 26 35
59 62 64 15 54
6 97 17 7 0 0 84 5 0 11 8
Total 376 461 382 443 352 845 480 496 505 569
Total 667 569 479 526 379 845 505 642 511 262
-536-
Company Sanitized. Does not contain TSCA CBI
pubchronic Toxicity ^O-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline Male Rats/Group V: 5 mg/kg/day
NAunmimbaelr 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
Successive 10-Minute Intervals
I 2345
134 140
91
138 162 141
67 5 53 . 17
124 163 143 141 157
149 138 128 30 14
157 136 140 92 19
122 116 126 128 126
130 136 148 133 147
128 161 146 159 129 132 120 159
31 84
109 120 129
38
9
Baseline Male Rats/Group VH: 25 mg/kg/day
NAunmimbaelr
12
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
158 143 120 123 157 135 141 136 142 137 128 138 126 142 141 130 130 134 133 150
Successive 10-Minute Intervals 345
153 142
88
130 152
30
100 4 4
40 5 2
134 151 159
136 .161 130
113 -42
1
933
134 80
6
135 131
37
6 7 3 151 15 6 131 92 8 17 14
6 63 3 10 1 145 124 15 10 14 13
Total 444 514 879 474 550 749 786 633 641 419
Total 747 558 410 325 868 817 439 296 498 599
- 537-
Company Sanitized. Does not contain TSCA CBI
[ gSubchxonic Toxicity 90-Day Oral Gavage Study in Rats ______
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline
Male Rats/Group IX: 125 mg/kg/day
Animal
Number
12
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
133 137 66 76 110 121 152 161 144 157 151 172 121 143 138 135 117 120 141 141
Successive 10-Minute Intervals 345
67 52
5
69 67 43
141 137 121
163 18
1
110 1 4
162 134
98
131 142 145
138 54 12
123 47
4
151 77
6
6 1 9 124 19 2 35 72 7 2 12
Total 395 330 754 514 418 752 754 484 413 528
-538 -
Company Sanitized. Does not contain TSCA CBI
^Subchronic Toxicity "90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline
Female Rats/Group II: 0 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 1 2 3 4 5.
655009 655015 655019 655035 655062 655068 655071 655072 655101 655109
174 97 150 127 147
135 94
4 108 124
135 158 163 142 103
121 144
122 144
132 108
120 95
33 4
133 179 142 153 128
118 126 128 137 144
152 152 138 140 149
148 162 160 159 163
120 87 74 116 156
Baseline Female Rats/Group IV: 1 mg/kg/day
Animal Number
12
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
124 126 153 139 138 129 105 126 126 130 149 128 150 131 150 165 66 59 151 139
Successive 10-Minute Intervals 345
163 127 132
105 134 133
139 27
8
125 139 122
133 104
4
104 136 130
106 45 127
151 43
3
74 62 73
143 155 116
6 Total
101 -1137
7 9 116 108 60 172 131
796 578 708 535 504 851 761 791 964 684
6 Total 154 826 98 762
5 446 62 679 1 498 85 732 99 658 5 517 57 391 141 845
- 539 -
Company Sanitized. Does not contain TSCA CBI
Subchronic Toxicity 90-Day Oral Gavage Study in Rats _______
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline Female Rats/Group VI: 5 mg/kg/day
NAunmimbaelr 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
Successive 10-Minute Intervals
i 2345
148 57 54 163 157
118 125 136 112
3
128 126 127
8 10
134 147 143 139 143
134 136 138 141
43
153 140 154 139
60
129 101 106 134 117
147 146 168 146 142
123 128 123 108 126
156 139 147 131 149
Baseline
Female Rats/Group VIII: 25 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 1234 5
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
137 119 113 77 11
130 130 132 111 131
118 96 130 134 136
134 131 135 108
4
151 132
89 139 120
172 146 143 146 150
146 149 132 154 141
150 79 156 146 26
120 137 132
85
3
124 154 159 166 141
6 111
2 16 153 11 3 121 139 HI 168
6 58 13 90 1 86 144 39 53 3 137
Total 690 496 415 859 603 649 708 888 719 890
Total 515 647 704 513 717 901 761 610 480 881
-540-
Company Sanitized. Does not contain TSCA CBI
JSubchronic Toxicity "90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Baseline
Female Rats/Group X: 125 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals 1 2 3 4 '5
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
146 139 143
72
0
133 122 125 126 111
64 61 , 67 60 38
137 154 138 152 125
129 152 124 144 163
148 147 140 181 145
155 184 . 107 42 42
146 150 177 177
54
133 137 141 143 120
123 136 151 142 145
6 2 133 13 148 151 137 0 4 110 132
Total 502 750 303 854 863 898 530 708 784 829
-541-
Company Sanitized. Does not contain TSCA CBI
Q lB H M M H H lIM ^S u b ch ro n ic Toxicity 90-Day Oral Gavage Study in R a t s _______________ __ ________________________________ DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13 Male Rats/Group I: Omg/kg/day
NAunmimbaelr
1
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
120 155 140 142 120 129 158 126 166 150
Successive 10-Minute Intervals 2345
133 125 101 143
152 147 148
70
131 119 126 109
151 125 128 128
132 114 126 121
142 139 155 139
148 131 141 114
136 146 143 124
155 139 141 145
158 150 157 137
6 7 32 100 53 127 150 122 150 88 124
Week 13 Male Rats/Group IE: 1 mg/kg/day
NAunmimbaelr
1
Successive 10-Minute Intervals 2345
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995a
151 156 148 151 150
135 134 128 125 123
144 151 138 125
73
136 164 155 141 139
152 149 101 102
23
154 146 139 124 148
132 132 137 146
78
128 149 141 135 158
146 152 151 151
78
58 65 55 60 59
6 138 133 22 95 30 112 26 121
7 58
Total 629 704 725 727 740 854 814 825 834 876
Total 894 778 653 830 557 823 651 832 685 355
aData inaccurate due to sensor malfunction; data excluded from summary table and statistical analysis
-542-
Company Sanitized. Does not contain TSCA CBI
Subchronic Toxicity '90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13 Male Rats/Group V: 5 mg/kg/day
NAunmimbaelr 654911 654916 654917 654959 654961 654967 654998 654907 654980 655005
Successive 10-Minute Intervals
12 3 4 5
144 124 118 142
53
124 133 127 131
86
134 157 134 135 104
154 162 124 34 45
131 132 135 .108 116
120 119 104
74 120
150 151 149 113 138
154 156 151 113
3
142 137
99 110 100
136 113
98 126 129
Week 13
Male Rats/Group VU: 25 mg/kg/day
Animal Number
Successive 10-Minute Intervals i 2345
654922 654923 654952 654958 654975 654989 655001 655006 654930 654940
145 147 130 134 108
104 121
67 133
12
133 124 100 82 53
136 143 144 104 101
150 124
93 117
60
138 100 3 3 0
103 119 121 99 58
133 141 150 158 128
123 135 132 116 108
134 139 141 144 106
6 11 164 13 127 124 86 97 4 19 16
6 128 23 123 80 124
2 43 111 115 121
Total 592 765 677 646 746 623 798 581 607 618
Total 792 460 615 708 668 246 543 821 729 785
-543-
Company Sanitized. Does not contain TSCA C8I
ubchronic Toxicity ^90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13
Male Rats/Group IX: 125 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals i 2345
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
148 129 63 19
1
119 113 116 111 143
136 149 151 133 161
148 140 146
89 134
172 138 66 31 10
131 155 146 159 145
111 153 137 130 139
148 124 108 114
77
117 136 132 105
86
101 106 91 66 117
6 86 82 131 168 3 151 108 6 68 72
Total 446 684 861 825 420 887 778 577 644 553
-544-
Company Sanitized. Does not contain TSCA CBI
iSubchronic Toxicity `90-Day Oral Gavage Study in Rats__________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13 Female Rats/Group II: 0 mg/kg/day
NAunmimbaelr
i2
655019 655071a 655062 655068 655009 655015 655035 655072 655101 655109
148 145 124 127 134 123 143 136 147 149 120 117 161 150 138 139 74 110
Successive 10-Minute Intervals 345
158 114 153 127 141 132 146 163 134 134 142 142 118 137 114 116 125 124 152 136 149 100 104 108 100 71 89
6 124
149 158 117 37 109 140 136 121
Total 842
800 858 814 702 711
888
725 565
Week 13 Female Rats/Group IV: 1 mg/kg/day
NAunmimbaelr
I2
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
165 143 168 146 148 126 10 135 149 155 144 117 105 135 129 145 118 118 125 140
Successive 10-Minute Intervals
3 '4
5
156 123 108
135 144
81
108 163 153
118 111 107
140 138 104
140 138 146
87 103 108
159 152 136
103 124 103
138 105 121
6 Total 116 811 79 753 127 825 120 691 106 792 22 707
1 539 28 749 131 697 129 758
aRat accidentally killed on test day 19.
-545-
Company Sanitized. Does not contain TSCA CB1
iSubchronic Toxicity 90-Day Oral Gavage Study in Rats_________
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13 Female Rats/Group VI: 5 mg/kg/day
Animal Number 655020 655029 655034 655039 655042 655066 655067 655087 655038 655054
Successive 10-Minute Intervals
I 234 5
108 139 129 44 15
125 122 141 128 127
124 123 89 34 107
131 112
84 105
47
131 152 112 137 116
103 141 118 127
99
107 151 61 88 128
155 159 128
96 132
142 143 132 118
93
125 136 156 122
99
6 132 86
6 103 106 94 122 139 74 145
Week 13
Female Rats/Group VH3: 25 mg/kg/day
NAunmimbaelr
Successive 10-Minute Intervals I 2345
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
143 133 132 163
25
123 117 141 123 110
119 116 132 122
19
153 141 109
80 105
160 109 109 98 61
121 154 133 144 141
116 138 146 101 103
149 156 161
77 135
146 132 101 139 143
120 137 155
37 120
6 132 145 67 92 92 129 103 145 76 131
Total 567 729 483 582 754 682 657 809 702 783
Total 728 759 575 680 629 822 707 823 737 700
-546-
Company Sanitized. Does not contain TSC CBI
^ ^^ubchronic Toxicity 90-Day Oral Gavage Study in Rats
DuPont-9478
INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS
Week 13
Female Rats/Group X: 125 mg/kg/day
Animal Number
Successive 10-Minute Intervals I 2345
655010 655030 6550372 655049 655061 655075 655077 655084 655088 655100
135 123 122 157 109
135 123' 118 120 118
57 56 66 56 45
137 133 128 139 101
156 103 118 135 127
135 147 168
63 154
136 128
74 119
36
134 171 143 127 124
145 137 143 128
88
113 140 155 150 144
52 124 . 11 92 139 140 5 95 2 133
Total 698 738 291 730 778 807 498 794 643 835
aData__________-- inaccurate due to sensor malfunction;----------------------------------------------------- data excluded from summary table and statistical analysis -547-
Company Sanitized. Does not contain TSCA CBI
__ ISubchronic Toxicity "90-Day Oral Gavage Study in Rats_________
DuPont-9478
APPENDIX K INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
-548-
Company Sanitized. Does not contain TSCA CBI
Toxicity ^90-Day Oral Gavage Study in Rats
DuPont-9478
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES
ABBREVIATIONS :
General :
ADEQ - adequate CLOT - saxrple clotted DECR - decreased INCR - increased NSR - no sample received for testing
NT - not taken or not performed NT-HEMOL - not taken due to hemolysis
OK - sample condition OK for testing. QNS - quantity not sufficient for testing RNV - result not valid UTD - unable to determine
> - greater than < - less than
Individual Hematology Values :
COND - sample condition RBC - red blood cell count
HGB - hemoglobin
HCT - hematocrit
MCV - mean corpuscular volume
.
MCH - mean corpuscular hemoglobin
MCHC - mean corpuscular hemoglobin concentration
RDW - red cell distribution width
ARET - absolute reticulocyte count
PLT - platelet count
WBC - white blood cell count
ANED - absolute neutrophil (all forms)
ALYM - absolute lymphocyte
AMON - absolute monocyte
AEOS - absolute eosinophil
ABAS - absolute basophil
ALUC - absolute large unstained cell . SPEC - special observations
Individual Red Blood Cell Morphology Values:
NORM
Normal
ANIS
anisocytosis
MIC microcytes
MAC macrocytes
POLY
polychromasia
HYPO
hypochromasia
ECHI
echinocytes
ACAN
acanthocytes
TARG
Target cells
RX rouleaux
HJB Howell-Jolly body
not observed or not examined; see whole blood sample condition
-549-
Company Sanitized, Does not contain TSCA CBi
^ (B B H H B H H H ^ S u b c h ro n ic Toxicity yO-Day Oral Gavage Study in Rats
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES (Continued)
ABBREVIATIONS: (Continued)
Individual White Blood Cell / Platelet Morphology values: NORM - Normal SM - Smudge white blood cells TOX - toxic neutrophils DB - Dohle bodies VC - vacuolated cytoplasm BC - basophilic cytoplasm' PCE - platelet cluitps / estimate GP - giant platelets BP - bizarre platelets SPEC - special observations - - not observed or not examined; see whole blood saiiple condition
Individual Coagulation Values: PHEM - plasma hemolysis PLIP - plasma lipemia PICT - plasma icterus PT - prothrombin time APTT - activated partial thromboplastin time
Individual Clinical Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT - alanine aminotransferase SDH - sorbitol dehydrogenase ALKP - alkaline phosphatase BILI - total bilirubin BUN - urea nitrogen CREA - creatinine CHOL - cholesterol TRIG - triglycerides GLUC - glucose TP - total protein ALB - albumin GLOB - globulin CALC - calcium IPHS - inorganic phosphorous NA - sodium K - potassium CL - chloride PHEM - plasma hemolysis from blood sample for fluoride determination PLIP - . plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLU - plasma fluoride
DuPont-9478
-550-
Company Sanitized. Does not contain TSCA CBI
^Subchronic Toxicity '90-Day Oral Gavage Study in R ats_________
DuPont-9478
INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA
EXPLANATORY NOTES (Continued)
ABBREVIATIONS: (Continued)
Individual Urinalysis Values: QUAL - quality (modifies color) COL - color CLAR - clarity VOL - volume UOSM - urine osmolality PH - the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET - ketone UBIL - urine bilirubin BLD - blood URO - urobilinogen UFL - urine fluoride UMTP - urine protein SPEC - special observations
Individual Urine Microscopic Examination Values: EPIT - epithelial cells UWBC - urine white,blood cells URBC - urine red blood cells NCRY - normal crystals MICR - microorgani sms SPER " sperm SPEC - special observations
KEY:
Special Observations:
1 - trace 2 - few
3 - moderate 4 - many
Urine Microscopic Values:
EPIT/UWBC/URBC
NCRY/MICR
SPEfiM/MUCUS
per high power field
per high power field
per low power field
_________ (4Ox)_______________________(4Ox)_______________________ (lOx)_______
1 - 1-10
1 - 1-25%/field
1 - 1-5
2 - 11-50
2 - 26-50%/field
2 - 6-20
3 - >50
3 - >50%/field
3 - >20
NOTES:
When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records:
the sample was clotted (CLOT) there was insufficient sample for testing (QNS) a valid result could not be obtained (RNV) the sample was not suitable for testing the animal died prior to sample collection no sample was available for testing (NSR)
When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For exanple, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data.
-551-
Company Sanitized. Does not contain TSCA CBI
"90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
Animal Number
COND
RBC Xl06//XL
HGB g/dL
Male, Group I - 0 mg/kg/day - Day 48
654903 654925 654928 654929 654936 654950 654953 654972 654987 654993
OK OK OK OK OK OK OK OK OK OK
7.83
8.48
7.98
8.68 8.10
8.48
8.10 . 8.86
7.98 .
8.82
14.5 15.7 15.1 15.4 15.0 15.3 14.7 15.4 14.1 16.2
Male, Group III - 1 mg/kg/day - Day 48
654908 654913 654932 654938 654941 654946 654947
654960 654984
654995
OK OK OK OK OK OK OK OK OK OK
8.61
7.91
8.88
8.15
8.04 8.03 8.56
8.40
8.21
7.77
15.3 14.9 16.4 14.6 14.1 14.6 16.2 15.1 15.3 15.4
Male, Group V - 5 mg/kg/day - Day 48
654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
OK OK OK OK OK OK OK OK OK OK
8.24 8.29 8.26 8.05 NT
8.08 8.33 8.32 8.07
8.01 .
15.5 15.1
14.9 15.3
NT 14.7 15.815.2 14.9 14.8
HCT %
46.0 49.8 47.3 49.8 48.3 48.2 46.6 48.8 46.7 51.3
49.5 46.2 52.2 45.9 45.3 47.5 51.2 48.4 48.2 48.5
50.1 47.6 48.2 49.2
NT 47.8 49.8 48.6 47.7 46.4
Individual Hematology Values
MCV MCH MCHC RDW fL pg g/dL %
ARET
x l 09/L
PLT WBC
x 103/m L x 103/m L
58.8 58.7 59.3 57.3 59.7 56.8 57.6 55.1 58.6 58.2
18.5 18.5 18.9 17.7 18.6 18.0 18.1 17.4 17.7 18.3
31.4 31.5 31.8 31.0 31.1 31.7 31.5 31.6 30.2 31.5
12.1
11.5
12.2 11.6
12.5
11.2 11.8
11.9
12.3
12.1
211.0
215.8 191.6 193.9 194.0 205.0
221.1
231.9 240.9 220.5
847 1106 1184
814 RNV 998 RNV RNV
1110
RNV
17.02 15.00 13.95 12.96 12.79 14.01 12.51 10.54 17.84 15.17
57.5 58.4 58.8 56.3 56.3 59.1
59.8 57.6 58.7 62.3
17.8 18.9
18.5 17.9 17.5 18.2 18.9 17.9 18.6 19.8
30.9 32.3 31.4 31.8 31.0 30.9 31.6 31.1 31.7 31.8
11.4
11.2 11.1 11..2
11.9
12.1
11.6 12.1 12.0 10.8
207.7 174.9
193.7 196.3 247.6
210.1
250.3 185.2
183.7
210.6
RNV 1073 1094 RNV RNV RNV RNV RNV 1104
1122
9.81 16.38 17.29 17.48 18.44 13.28 22.51 13.97 11.01 16.52
60.7 57.4 58.4 61.1 NT 59.1 59.8 58.4 59.1
58.0
18.8 18.2 18.0 19.0
NT 18.2 19.0 18.2 18.5 18.5
30.9 31.7 30.9 31.1
NT 30.7 31.7 31.2 31.2 31.9
11.4
10.8
12.5
12.4
NT
11.9
11.6 12.6
11.3
12.5
213.4 172.4 280.9 310.7
NT 250.3 183.9 248.0 214.1 248.2
961 RNV RNV
1026 NT
1102
1008 1267
1029 983
16.45 17.07
10.00
15.65 NT
12.57
12.82 22.89 12.92 15.71
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
552
^ j9h0H-DMayHOHraHl GHavmagPe^SStuudbycihnrRoantsic Toxicity
)
Animal Number
COND
RBC
x l 06/fU,
HGB g/dL
HOT %
ale, Group VII - 25 mg/kg/day - Day 48
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
OK OK OK OK OK OK ' OK OK OK OK
8.03 7.99
8.01
7.83 7.87 8.04 7.88 8.14
7.73 7.46
14.4 15.1 15.1 14.4 14.8 14.4 14.6 15.9 14,4 14.8
46.4 46.6 47.4 45.2 47.3 48.1 46.3 50.0 45.4 47.0
ale, Group IX - 125 mg/kg/day - Day 48
654914 654921 654951 654955 654965 654979
654983 654986 654996 655003
OK
OK OK 'OK OK OK OK OK OK OK
8.44 7.74 8.38 7.51 7.48 7.04 7.93 7.61 7.76 7.88
15.1 14.6 15.5 14.3 14.0 13.3 15.3 14.8 14.2 14.2
49.6
46.4 49.5 45.9 44.8 42.7 48.6 47.9
43.8 44.9
Individual Hematology Values MCV MCH MCHC RDW fL pg g/dL %
ARET x 109/L
x lPoL3/Ta h
WBC xl03/ML
57.8 58.4 59.1 57.6 60.0 59.9 58.8 61.5 58.7 63.0
17.9 18.9 18.9 18.4 18.8 17.9 18.6 19.5 18.6 19.8
31.0 32.4 31.9 32.0 31.3
29.9 31.6 31.8 31.7 31.4
12.5
12.3
11.7
12.8
11.9
13.9
11.6 11.1 12.6
11.7
256.4 237.1 265.4 291.8 207.7 309.1 249.9
212.6
188.1 178.2
987 997 RNV RNV RNV RNV 954 RNV 1046 1074
13.14 17.40 18.46 17.96 11.37
15.08 16.02 20.45 11.26 13.48
58.8 60.0 59.0 61.1 59.9 60.7 61.3 63.0 56.4
56.9
17.9
18.8 18.5 19.1 18.7
18.9 19.-3 19.4 18.3 18.0
30.4 31.3 31.3 31.2 31.2 31.1 31.4 30.9 32.5 31.6
13.5
12.1
13.0
13.4 13.6
13.2 11.4
11.6
14.4
13.1
276.3 244.0 258.2 247.1 237.7
309.0 244.1 231.1 291.0 281.9
985 RNV RNV 1207 RNV RNV 718 880 959 RNV
20.10
13.31 18.02 22.06 18.80
11.74 16.60 11.31 19.49 11.49
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-553-
Company Sanitized. Does not contain TSCA CBI
t 90-Day Oral Gava_g_e_S_tudyubinchRraotnsic Toxicity
Animal Number
ANEU xlO /m L
ALYM
AMON
Xl03/Mli xl03/ML
x lAOE3O/S h
Male, Group I - 0 mg/kg/day - Day 48
654903 654925 654928 654929 654936 654950 654953 654972 654987 654993
1.60 1.99 1.23
1.36 1.28 1.96 1.42 1.16 2.98 1.35
14.54 12.37
12.12
10.98 11.09
11.42 10.59 9.38 14.04, 13.13
0.40 0.28 0.33. 0.24 0.27
0.30 0.30
0.00
0.49 0.37
0.29
0.13
0.11
0.13
0.05
0.14
0.06
0.00 0.12 0.12
Male, Group III - 1 mg/kg/day - Day 48
654908 654913
654932 654938 654941 654946 654947 654960 654984 654995
1.51 1.84
0.77 1.55 1.83
1.12
3.60 1.26 0.97 1.63
7.93
13.79 16.12 15.14 15.96 11.58 18.46
12.20
9.56 14.28
0.13
0.20 0.12
0.31 0.32
0.26
0.45 0.18
0.24
0.23
0.09
0.16 0.09 0.09 0.09
0.18
0.00
0.15
0.10
0.13
Male, Group V - 5 mg/kg/day - Day 48
654907 654911
654916 654917 654959 654961 654967 654980 654998 655005
1.42 2.89 0.93 2.54
NT 1.38 1.55 2.55 2.06 2.29
14.36 13.40 8.81 12.25
NT 10.67 10.59 19.35 10.17 12.89
0.31 0.55 0.14 0.54 NT 0.24 0.44 0.47 0.49 0.23
0.13
0.05
0.06
0.10
NT
0.11
0.07
0.20
0.07
0.13
Individual Hematology Values
ABAS xlOVnL
ALUC
x l 03/iiL
0.08 0.16
0.09
0.15
0.04
0.11
0.06
0.00 0.10 0.12
0.10
0.07
0.07
0.10
0.07
0.07
0.08
0.00 0.11
0.09
0.09 0.30
0.09 0.26 0.15
0.08
0.00 0.11
0.09
0.18
0.06
0.09
0.10
0.14
0.09
0.07
0.00
0.07
0.05 0.07
0.11
0.09
0.03 0.14
NT
0.08
0.10 0.21
0.07
0.10
0.11
0.08 0.05 0.08 NT
0.08
0.07
0.11
0.06 0.08
554
3
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
L90-Day Oral Gavage St_udSyuibnchRraotnsic Toxicity
Animal Number
ANEU
x 103/m L
ALYM xlOVizL
AMON xIOVmL
xlAOE3O/SL
Male, Group VII - 25 mg/kg/day - Day 48
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
0.89 2.43 2.19
3.13 1.76 1.23 1.49 2.28 2.62 1.98
11.75 14.22 15.43 14.05 9.01 13.43 14.02 17.64 7.94 , 10.94
0.17
0.37 0.40
0.40
0.20
0.19 0.19
0.22
0.38
0.38
0.08
0.14
0.14
0.14
0.12 0.10
0.06
0.12
0.14 0.04
Male, Group IX - 125 mg/kg/day - Day 48
654914 654921 654951 654955 654965 654979 654983 654986 654996 655003
3.01 1.75 3.70
2.98 1.26 0.99
2.22
1.53
1.55 1.39
16.26 11.08 13.59 18.25 16.93 10.45 13.74 9.41
17.28 9.88
0.40 0.28
0.37
0.44
0.22 0.12
0.28 0.19
0.28
0.11
0.18
0.12
0.15 0.15
0.08 0.05 0.18 0.09
0.10 0.11
Individual Hematology Values
ABAS xl03/iiL
x lA0L3U/CfiL ,
0.16 0.17 0.16 0.15 0.21 0.07 0.18 0.11
0.11 0-07
0.10
0.08 0.13 0.10 0.07 0.06 0.08 0.09
0.07 0.07
0.15 0.04
0.11 0.12
0.23
0.07
0.12
0.05
0.16 0.00
0.10 0.06
0.10 0.11
0.08
0.06
0.06
0.04
0.12
0.00
555
)
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
)
Animal Number
COND
RBC xl06/fiL
HGB g/dL
Male, Group I - 0 mg/kg/day - Day 93
654903 654925 654928 654929 654936 654950 654953 654972 654987
654993
OK OK OK OK OK OK OK OK OK OK
8.29
8.66
8.08 8.93 8.46
8.28
8.75 9.04 8.37
8.82
15.4 16.5 15.7 16.3 15.7 15.0 15.6 16.4 - 15.4 16.8
Male, Group III - 1 mg/kg/day - Day 93
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
OK OK OK OK OK OK OK OK OK OK
8.69
8.20
8.99 8.81
8.70 8.71
8.03 8.93 8.44
7.96
15.7 15.1 16.9 15.5 15.5 16.4 15.5 16.4 16.1 15.6
Male, Group V - 5 mg/kg/day - Day 93
654907 654911 654916 654917 654959 654961 654967 654980 654998
655005
OK OK OK OK OK OK OK OK OK OK
8.27 8.38 8.64 7.96 8:18 8.42 8.54 8.44 8.41 7.98
16.3 15.1 15.7 15.4 15.6 15.6 16.2 15.5 15.7
14.6
HCT %
46.1 48.7 46.3 48.8 47.8 44.8 48.4 50.1 46.4 49.8
47.0 45.9 50.4 48.2 47.0 50.7 46.8 49.5 47.5 47.1
47.8 46.8 48.1 45.5 44.9 47.7 49.0 47.6 48.4 44.6
Individual Hematology
MCV MCH MCHC fL p g g/dL
55.6 56.2 57.2 54.6 56.5 54.1 55.3 55.4 55.5 56.5
18.6 19.1
19.5 18.2 18.5 18.1 17.9 18.2 18.4 19.1
33.4 34.0 .34.0 33.3 32.8 33.5 32.3 32.8 33.1 33.7
54.1 56.0 56.1 ' 54.7 54.0 58.2 . 58.3 55.5 56.3 59.2
18.0 18.4
18.8 17.6 17.8 18.8 19.3 18.3 19.1 19.6
33.3 32.8 33.6 32.2 33.0 32.3 33.1 33.0 34.0 33.2
57.8 . 55.8
55.7 57.1 54.9 56.7 57.4 56.3 57.6 55.9
19.7 18.0 18.2 19.4 19.1 18.5 19.0 18.4 18.6 18.4
34.0 32.3 32.7 34.0 34.7 32.7 33.1 32.7 32.3 32.8
Company Sanitized. Does not contain TSCA CBI
-556-
Values
RDW %
ARET
PLT
WBC
x!03/fiL xl03//iL X103/ML
13.5 12.1 13.3 11.9 13.4 13.2 12.9 12.4 12.8 12.9
209.40 184.00 161.20 131.40 186.30 179.70 141.10 177.50 172.50 180.80
1142 1377 1390 1019 1187 1120 1233 RNV 1369 1149
18.08 12.47 15.58 9.18 12.86 9.73 10.40 6.75 16.24 10.61
12.3 12.0
11.8 12.7
12.9 11.7
12.2 12.8
12.2
11.4
170.10 136.50 149.10 202.20 161.20 134.60 182.10 162.20 143.70 150.60
1102 1245 1300 1411
1222 RNV RNV 1103 RNV 1203
9.48 12.48 14.29 15.40
12.23 11.46 13.29 11.01 10.09 14.78
12.4 12.0 12.3 12.4 12.3 12.6 12.2 14.1 12.0 13.8
171.70 146.20 193.90 235.00 186.00 201.50 141.80 219.20 209.50 165.30
1165 1244 RNV 1315 1096 1379 966 1216 1211 RNV
10.21
11.22 9.77 15.92 12.37 10.57 11.44 16.81 9.67 9.62
90-Day Oral Pavage StjuSduybicnhRroatnsic Toxicity
Animal Number
COND
RBC xl06/aL
HGB g/dL
HCT %
Male, Group VII - 25 mg/kg/day - Day 93
654922 654923 654930 654940 654952
654958 654975 654989 655001 655006
OK OK OK OK OK OK OK OK OK OK
7.99 8.32
8.02
7.86 7.97 8.14 8.05 8.63
8.19 . 8.07
15.2 15.7 14.8 14.6 15.4 15.6 15.5 17.1 15.4 16.3
44.7 47.0 45.3 44.7 46.6 46.1
47.8 51.1 46.4 47.9
Male, Group IX - 125 mg/kg/day - Day 93
654914 654921 654951 654955 654965 654979 654983 654986 654996' 655003
OK OK OK OK OK OK OK OK OK OK
8.19 8.09 8.08 6^96 7.82 7.07 8.07 7.53 7.73 8.05
15.9 15.6 15.4 14.1 15.0
13.9 16.1 15.1 14.3 14.9
49.1 46.7 46.9 42.0 45.1 42.5 47.7 47.7 42.9
44.4
Individual Hematology Values
MCV MCH MCHC RDW
fL
pg g/dL
%
ARET
PLT
WBC
X103/ML X103/ML X103/ML
56.0 56.5 56.4 56.9 58.4 56.7 59.4 59.2 56.6 59.3
19.0 18.9 18.5 18.6 19.3 19.1 19.2 19.8 18.8
20.2
34.0 33.4 32.8 32.6 33.1
33.8 32.3 33.5 33.3 34.1
12.8 12.6
12.5
12.7
12.5
13.5 13.2
12.0
13.2
12.2
172.20 229.40 197.60 202.40 160.70 229.00 224.00 195.10 181.50
134.00
1332 1398 1348 1376 1106 1094 RNV RNV 1153
1205
9.19 17.36
10.48 9.14
8.86
16.48 15.11 17.91
14.40 14.62
59.9 57.7 58.1
60.4 57.6 60.1 59.1 63.3 55.6 55.1
19.4
19.2
19.0
20.2
19.1
19.7
20.0 20.0
18.5
18.5
32.3 33.3 32.8 33.5 33.2 32.8 33.8 31.6 33.3 33.6
12.2
12.7
12.8
18.2 13.3
12.6
12.7 13.7
14.9
13.3
158.10 180.70 187.00 324.30 165.10
253.40 217.80 278.20 216.40 187.40
1190 1406 1178 1686 1454 1232 1003 1084
RNV 1239
16.26
12.94
14.26 22.59
13.10
9.25 13.11
10.10
16.98 10.26
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-557-
c 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
Individual Hematology Values
Animal Number
x lA0N3E/U L
ALYM
AMON
AEOS
ABAS
ALUe SPEC
xl03//L xl03/fiL xl03//iL xl03/L xl03/iL
Male, Group I - 0 mg/kg/day - Day 93
654903
654925 654928 654929 654936 654950 654953 654972 654987 654993
2.47
2.19 1.51 2.04
1.68
1.91
1.59 0.81 3.21
1.20
14.84 9.88 13.60 6.84 10.71 7.44 8.39 5.67 12.47 9.04
0.31
0.14
0.15
0.12
0.28
0.21 0.21 0.20
0.24
0.22
0.31 0.16 0.15
0.15 0.06
0.13
0.11
0.07 0.17
0.08
0.06
0.05
0.09
0.02
0.05
0.02
0.03
0.00
0.05
0.03
0.09
0.06 0.08
0.03 0.08 0.03 0.06
0.00
0.09
0.04
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
Male, Group III - 1 mg/kg/day - Day 93
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
1.81
1.29
1.00
1.63
1.90 1.49
1.06 1.35 1.14 1.78
7.40 10.79 12.97 13.18 9.94 9.51 11.56 9.23 8.38 12.51
0.15
0.09
0.12
0.33
0.21
0.23 0.53
0.14
0.38
0.23
0.07
0.19
0.08
0.10
0.06
0.23
0.13
0.19
0.12 0.10
0.03
0.07
0.05
0.04
0.06
0.00 0.00
0.04
0.02
0.08
0.03
0.06 0.07
0.12
0.06
0.00 0.00
0.05
0.05 0.08
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
Male, Group V - 5 mg/kg/day - Day 93
654907
654911 654916 654917 654959 654961 654967 654980 654998 655005
0.98 1.13
1.34 4.05 2.03 1.39 1.40 3.33 1.29 1.14
8.99 9.73
8.04 11.18 9.76 8.80 9.68 12.51 8.13 8.03
0.10 0.22
0.23
0.47
0.34
0,20 0.20
0.41
0.16
0.11
0.12
0.07
0.09
0.11
0.17 0.09 0.06 0.43 0.03 0.24
0.04 0.04
0.02
0.05 0.03
0.03 0.04 0:05 0.03 0.06
0.04 0.05 0.04 0.06 0.05 0.06 0.06 0.08 0.04 0.05
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-558-
90-Day Oral Gavage Study in Rats Toxicity
Animal Number
ANEU x 1 0 3 / jL
ALYM X103/ML
AMON xl03/iD
AEOS xl03/iiL
Individual Hematology Values
ABAS
ALUC SPEC
xl03/fiL xl03/fL
Male, Group VII - 25 mg/kg/day - Day 93
654922 654923 654930 654940
654952 654958 654975 654989 655001 . 655006
1.53 4.05 1.85 2.09
1.44 4.65 1.58 2.73 3.13 1.77
7.40 12.45 8.26 6.71 7.07
11.19 12.58 14.66 10.70 _ 12.36 '
0.14 0.38 0.19 0.17
0.15 0.38 0.35 0.24 0.39 0.25
0.06
0.34
0.11 0.10
0.14
0.16
0.48
0.11
0.08 0.09
Male, Group IX - 125 mg/kg/day - Day 93
0.03 0.05 0.04
0.03 0.03 0.05 0.05 0.05 0.03 0.08
0.04 0.09 0.04 0.03 0.04 0.05 0.08 0.12
0.07 0.08
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
654914 654921 654951 654955 654965 654979 654983 654986
654996 655003
2.27 2.31
2.88
3.70
1.39
0.95
2.20
1.46
2.56
2.00
13.42 10.17 10.95 18.24 11.27
8.01
10.50 8.38 13.87
7.79
0.24
0.20
0.15 0.32
0.22
0.13
0.18
0.14
0.26 0.23
0.18
0.18
0.15 0.19
0.12 0.10 0.12
0.06
0.17
0.17
0.05
0.02
0.03 0.06 0.05 0.03 0.04
0.03
0.05 0.03
0.09 0.06
0.10 0.08 0.06 0.03 0.06 0.03 0.06 0.04
BLOOD VOLUME SIGNIFICANTLY MORE THAN SPECIFIED
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-559-
90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
)
Animal Number
COND
RBC xl06/(iL
HGB g/dL
Male, Group I - 0 mg/kg/day - :Day 183
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
OK OK OK
OK OK OK OK OK OK
OK
8.80
8.98
8.20
9.50
8.82 8.74
7.95
8.66
8.81
8.63
16.2 15.8 15.0 16.0 15.0 14.8 14.8 15.3 16.3 14.8
Male, Group IX - 125 mg/kg/day - Day
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
OK OK OK OK CLOT OK CLOT CLOT OK OK
8.17 7.74 8.98 8.53
NT 9.00 NT
NT 8.28 8.04
15.0 14.6 15.2 15.6
NT 15.4
NT NT 15.2 15.0
HCT %
49.4 48.6 46.7 49.8 46.9 48.4 44.7 47.3 50.1 45.8
45.8 44.0 47.8 47.8
NT 48.8
NT NT 46.2 45.9
Individual Hematology Values
MCV fL
MCH
pg
MCHC g/dL
RDW %
ARET
PLT
WBC
xl03/aL xl03//iL x 103/m D
56.1 54.1 56.9 52.5 53.2 55.3 56.3 54.6 56.9 53.1
18.4 17.6 18.2
16.9 17.0 16.9 18.7 17.7 18.5 17.2
32.8 32.6
32.0
32.2 32.0
30.6 33.2 32.4
32.5 32.4
12.8
13.7 13.5
13.8 14.4
14.2 13.6 12.9 13.4 . 13.1
3.50.30 150.50 192.20
175.80 186.90 174.80 236.20 170.80 178.60 174.00
RNV RNV
1100
RNV 1420
1265 1151
866
RNV
1065
12.34
12.68
17.42
18.99 14.48
15.79 10.29
8.00
12.36
12.30
56.1 56.8 53.2 56.0
NT 54.2 , NT
NT 55.8 57.0
18.4 18.9 16.9 18.3
NT 17.1
NT NT 18.4 18.6
32.8 33.2 31.7 32.6
NT 31.6
NT NT
33.0 32.7
13.5 14.1
13.0 13.9 NT
13.0 NT NT
12.6 12.8
203.20 225.90 179.50 185.30
NT 153.50
NT NT 195.70 175.70
1063
1302 861 1092 NT 967 NT NT 957 1276
15.54 15.89 15.42 16.17
NT 12.25
NT NT 10.57 11.95
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
560
Company Sanitized. Does not contain TSCA CBI
L90-Day Oral Gavage S_tu_dyuibnchRraotnsic Toxicity
Animal Number
ANEU x 103/L
ALYM x 103/m L
AMON X103/ML
AEOS x 1Q3/L
Individal Hematology values
ABAS
ALUC
xl03/fiL X103/ML
Male, Group I - 0 mg/kg/day - Day 183
654909 654910 654915 654924
654927 654943 654949 654956 654992 654994
2.02
3.08 6.08 2.60 3.30 3.38
2.18 1.64 1.41 1.76
9.71 9.09 10.38 15.52
10.20
11.55 7.39 5.75 10.34 9.94 '
0.33 0.31 0.64
0.34 0.58 0.48 0.42 0.42
0.20
0.24
0.16
0.11
0.13
0.26
0.17
0.18
0.21
0.09 0.26 0.14
0.08 0.04 0.13 0.19 0.16 0.14 0.05 0.06 0.12 0.17
0.04 0.05 0.07 0.08 0.06 0.06 0.05 0.04 0.03 0.06
Male, Group IX - 125 mg/kg/day - Day 183
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
2.43 3.36 2.80 2.95
NT 2.03 NT NT
1.92 1.94
12.26 11.65 11.78 12.27
NT 9.62
NT NT 7.90 9.21
0.51 0.59 0.37 0.33
NT 0.24
NT NT .0.44 0.55
0.16 0.15 0.14 0.28
NT 0.18
NT NT 0.19 0.14
0.12 0.08 0.25 0.25
NT 0.14 NT NT 0.06 0.05
0.07 0.07 0.08 0.09
NT 0.04
NT NT 0.07 0.06
561
)
DuPont-9478
_90-Day Oral Gavage St_udSyubicnhRroantsic Toxicity
)
Animal Number
COND
RBC xlOV^L
HGB g/dL
HCT %
Female, Group II - 0 mg/kg/day - Day 49
655016 655025 655031 655032 655036 655079 655083 655098 655099 655107
OK OK OK OK OK OK OK OK OK OK
8.75
8.21
8.50 8.49
8.38
8.19
7.79 7.98
8.04 8.51
16.4 15.5 15.8 15.3 16.2 15.5
14.7 15.2 15.5 15.6
52.0 48.0 49.6 49.5 50.8 48.6 46.3 47.2 48.8 49.4
Female, Group IV - 1 mg/kg/day - Day 49
655013 655033 655040 655041 655044 655086 655089 655090 655091
655108
OK OK OK OK OK OK OK OK OK OK
8.39 8.36 8.07 7.89 8.36 8.32
NT 7.58 7.81 8.03
16.2 15.9 15.0 15.0 15.6 16.0
NT 14.6 15.3 15.2
50.1 49.8 46.3 46.9 49.0 49.2
NT 45.1
48.0 48.2
Female, Group VI - 5 mg/kg/day - Day 49
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
OK OK OK OK OK OK OK OK OK OK
8.70 7.62
8.02
8.18
8.34 7.83 8.44 7.95 8.53 7.75
16.5 14.5 14.9
15.9 15.9 15.2 15.5 15.5 15.7 14.9
51.7 45.7 47.0 48.4 49.0 47.9 48.2 49.5 48.9 46.7
Individual Hematology
MCV MCH MCHC fL pg g/dL
59.5 58.5 58.4 58.3 60.6 59.3 59.4 59.2
60.6 58.0
18.8 18.9 18.6 18.0
19.3 18.9
18.8 19.0 19.3 18.3
31.6 32.4 31.8 30.9 31.9 31.9 31.7 32.1 31.8 31.5
59.8 59.6 57.4 59.5 58.6 59.2
NT 59.5 61.5 60.1
19.3 19.1 18.6 19.0 18.6 19.2
NT
19.3 19.6 19.0
32.4 32.0 32.4 32.0 31.8
32.5 NT 32.5 31.9 31.6
59.4 60.0 58.7 59.2 58.8 61.2 57.1 62.3 57.4 60.3
'
19.0 19.0 18.6 19.4 19.0 19.4 18.3 19.6 18.4 19.2
32.0 31.7 31.7 32.8 32.4 31.7 32.1 31.4 32.1 31.8
Company Sanitized. Does not contain TSCA CBI
-562-
Values
RDW %
ARET
x l 09/L
PLT
x 1 0 3/ mL
WBC
x 1 0 3/ mL
11.6 11.4 11.2 13.2
11.5 11.5 11.8 11.6 11.9 11.1
348.0 259.0 209.0 269.2
284.3 281.5 257.2 195.2 250.9 211.4
RNV 1015 971 965 RNV 1043 908 978 933 RNV
11.06 11.70 17.04 19.84 5.29 13.14 15.98 14.70 11.73 9.76
11.1 11.6 11.5 12.2 11.6 11.2 NT 11.8
11.9 11.3
196.9 204.5 194.7 257.4 206.4 225.8
NT 264.6
226.7 251.6
567 1024 945 910 957 630
NT 811 RNV RNV
11.92 14.85
1 9.99
14.33 8.16 13.69 NT 13.78 11.93 7.85
11.7 12.7 11.2 11.4 11.6 12.3 11.9 11.6 12.1 11.2
266.6 356.0 222.4 192.8 206.4 261.7 312.7 232.0 226.3 213.1
918 1512 1112 934 1021 1041 1118 RNV
1106 RNV
10.80 8.46 20.09 15.74 11.33 15.95 11.50 14.85
11.27 12.49
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
)
Animal Number
C0ND
RBC xlOVaL
HGB g/dL
HCT %
Female, Group VIII - 25 mg/kg/day - Day 49
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
OK OK OK OK OK OK OK OK OK OK
7.64 7.95 7.59 7.42
8.06 7.84 8.41 8.58 8.60 , 7.93
14.6 14.8 14.5 14.4 15.0. 14.2 15.4 15.7 15.9 14.9
46.1 46.4 45.3 44.0 46.6 44.2 47.7 50.1 50.8 46.4
Female, Group X - 125 mg/kg/day - Day 49
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
OK OK OK OK OK OK
OK OK OK OK
7.90 7.85 6.99 6.89 7.40 7.53 8.30 7.24 7.49 7.36
.
14.3 15.1 13.9 13.1 14.6 13.8 15.2 13.4 14.6 14.2
44.9 47.6 42.5 41.0 44.9 43.1 49.2 42.4 45.0 43.9
Individual Hematology Values
MCV MCH MCHC RDW
L
pg g/dL
%
ARET x 109/L
PLT WBC
x 103/m L x 103/m I
60.4 58.4 59.6 59.3 57.8 56.4 56.7 58.4 59.1 58.5
19.2 18.6 19.0 19.4
18.7 18.2 18.4 18.3 18.5 18.8
31.8 31.8 31.9 32.7
32.3 32.2 32.4 31.3 31.3 32.1
11.9
11.1 11.8 12.0
11.5
11.7
11.3
12.0
11.9
12.5
248.1
205.1
210.6
239.6
193.9 198.1 208.3 ' 189.4
192.2 286.0
889 1014 959 1259 RNV RNV 1055 635 831 975
10.07 12.16 16.11
13.50 14.86 9.32 10.55 17.03 12.57 9.38
56.9 60.7 60.9 59.6 60.7 57.3 59.3 58.6 60.0
59.7
18.2 19.3 19.9 19.0 19.8 18.4 18.3 18.6 19.5 19.2
31.9 31.8 32.7 31.9
32.6 32.1
30.9 31.7 32.5 32.2
11.7
12.0
11.4 12.4
12.5
11.6
11.7 12.4
12.2
11.7
252.2
202.8
228.3 265.8 239.9
252.4 251.4 251.0
233.6 228.6
RNV 806 RNV 1059 RNV
1213 908 RNV 902 RNV
10.93 7.74 9.54 9.40 11.07
10.39 14.89 9.84 17.93 9.29
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
-563-
Company Sanitized. Does not contain TSCA CBI
i90-Da_y__O_r_a_l_G_a_v_a_g_e_StudyiuibnchRraotnsic Toxicity
Animal Number
ANEU
x 1 0 3/ mL
ALYM ' AMON
x 1 0 3/ mL :k I O V m L
AEOS
x 1 0 3/ mL
Female, Group IX - 0 mg/kg/day - Day 49
Individual Hematology Values
ABAS
x 1 0 3/ mL
ALUC xlOVjiL
655016 655025 655031 655032 655036 655079
655083 655098 655099 655107
0.48 1.76
1.12
2.16 0.37 2.06 2.19 1.26 1.06
1.10
10.21
9.53 15.22 16.77 4.79
10.58 13.09 12.97 10.26 8.35
0.18 0.24 0.17 0.57 0.06
0.21
0.35 0.13 0.19 0.08
0.09 0.09 0.26 0.15 0.04 0.09
0.10
0.13 .
0.10
0.07
Female, Group IV - 1 mg/kg/day - Day 49
0.04 0.03 0.16
0.11
0.01
0.15 0.13
0.12
0.07 0.09
0.06 0.05
0.11
0.10
0.02
0.05 0.13
0.10
0.05 0.07
655013 655033 655040 655041 655044 655086 6550.89 655090 655091 655108
0.74 0.99 0.91 1.40 0.65
0.63 NT
1.65 0.72 0.76
10.78 13.39 8.77 12.34 7.20 12.71
NT
11.73 10.83 6.75
.0.25 0.24 0.13 0.33 0.16
0.12
NT 0.23 0.14 0.18
0.06 0.13 0.08 0.07 0.05 0.13 NT 0.09
0.12
0.10
Female, Group VI - 5 mg/kg/day - Day 49
0.05 0.05 0.05
0.10
0.06 0.05 NT 0.04 0.05
0.02
0.05 0.05 0.05
0.10
0.03 0.05 NT 0.05 0.06 0.03
655020 655029 655034 655038 655039 655042
655054 655066 655067 655087
1.29 1.42 1.32 1.65 2.40 2.04
1.10
2.19 0.90 0.70
8.97 6.71 18.22 13.36 8.46 13.30 9.78 12.07 9.97 11.43
0.26
0.11
0.24 0.31 0.15 0.38
0.11
0.39 0.19 0.18
0.18
0.11
0.08 0.17
0.11
0.08 0.13 0.09 0.13 0.08
0.07 0.06 0.13 0.15 0.13 0.07 0.30 0.05 0.04 0.03
0.03 0.05
0.10
0.11
0.08 0.08 0.09 0.07 0.04 0.05
564
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
^ 90J-DMay^ OBr^alBGBavBag^e^SStuudbycihnrRoantsic Toxicity
Animal Number
ANEU xlO3/
ALYM xlOVfiL
x lAOM3O/ N L
AEOS xlO3/!,
Female, Group VIII - 25 mg/kg/day - Day 49
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
1.33
0.57
0.88
1.08
1.11
1.13
0.66
2.29
3.14
2.11
8.35 11.16 14.66 11.92 13.28 7.65 9.58 13.98 8.58 6.84
0.20 0.20
0.19
0.13
0.15
0.38
0.12
0.42
0.48
0.25
0.09 0.07
0,12
0.13 0.09
0.10
0.05 0.15
0.23 0.09
Female, Group X - 125 mg/kg/day - Day 49
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
1.64 0.57
0.75 1.33 1.07
2.27
1.20
1.26 2.16 1.78
8.82
6.82
8.38 7.79
9.55 7.76 13.18
8.10
14.90 7.15
0.29
0.20
0.16
0.12
0.31
0.16
0.24
0.20
0.38
0.16
0.11 0.10 0.12
0.06
0.07
0.08 0.07
0.08
0.22 0.11
Individual Hematology Values
ABAS
ALUC
xloV/iL xlO3/ L
0.03 0.04 0.16 0.15 0-13 0.02
0.09
0.11
0.08 0.03
0.06 0.12
0.11
0.10 0.10 0.04
0.05 0.08 0.06 0.05
0.04
0.02
0.05 0.05
0.02 0.07 0.09 0.13
0.13 0.04
0.04 0.04 0.08 0.05 0.05 0.05 0.12 0.08 0.15 0.05
565
)
DuPont-9478
^P-Day Oral Gavage _S_tufdSyubinchRraotnsic Toxicity
)
Animal Number
COND
RBC xl06/fiL
HGB g/dL
HOT %
Female, Group II - 0 mg/kg/day - Day 94
655031 655016 655025 655032 655036
655079 655083 655098 655099 655107
OK OK OK OK OK OK OK OK OK
OK
8.10 8.00
8.06 8.59
8.33 8.08 8.60 8.48 8.34
7.84
15.5 15.8 15.9 16.2 16.7 16.1 16.7 16.7 16.3 15.5
45.8 45.3 46.6 48.2 48.7 46.8 48.2 49.2 48.0 44.8
Female, Group IV - 1 mg/kg/day - Day 94
655013 655033 655040 655041 655044
655086 655089 655090 655091
655108
OK OK OK OK OK OK OK OK OK OK
8.28 8.47 8.23 8.17 8.32 8.38 8.69 8.13 7.74 8.39
16.4 16.7 16.0 16.1 16.5 16.2 17.1 16.3 15.8 16.7
48.6 49.0 46.8 46.2 47.8 47.9 50.5 47.8 45.9
48.0
Female, Group VI - 5 mg/kg/day - Day 94
655020 655029 655034 655038 655039 655042 655054 655066
655067 655087
OK OK OK OK OK OK OK OK OK OK
8.42 8.13
8.90 8.31 8.58 7.91
8.53
8.10
8.75
8.19
16.9 16.0 17.1 16.5 17.1 15.7 16.4 16.7 16.5 16.4
49.2 46.5 52.0 47.8 49.5 45.3 48.4 48.8 48.4 47.5
Individual Hematology Values
MCV fL
MpCgH
MCHC g/dL
RDW %
56.6 56.6 57.8 56.1 58.5 57.9 56.1 58.1
57.5 57.1
19.2 19.8 19.7 18.9
20.0
19.9 19.4 19.7
19.6
19.8
33.9 34.9 34.2 33.7 34.2 34.4 34.6 34.0 34.0
34.6
10.8 1 1 .
10.3
11.7
11.2
10.3
11.0
11.3
11.4
10.2
58.7 57.8 56.9 56.5 57.4 57.2 . 58.2 58.8 59.2 57.3
19.9 19.7
19.5 19.7 19.9 19.3 19.7
20.1
20.4 19.9
33.8 34.1 34.3 34.9 34.7 33.7 33.9 34.1 34.4 34.7
11.0 11.0 11.0 11.2 10.8
10.7
11.2 10.8 12.0
10.4
58.5 57.2 58.5 57.5 57.7 57.2 56.7 60.3 55.3 58.0
20.1
19.7
19.2 19.8
19.9
19.9 19.3
20.6
18.9
20.0
34.3 34.4 32.9 34.5 34.5 34.8 34.0 34.2 34.1 .34.5
10.7
11.6
11.3
. 10.9
10.6
11.7
10.9
11.2
10.5
10.8
ARET
PLT
WBC
x 10 3/m L xl03//iL xl03/juL
104.40 207.80 136.00 173.20 161.50 133.70 137.70 120.70 128.50
110.00
1201
925 1197 928 1196 1248 942 976 1067
1153
13.17 6.41
8.01
19.52 7.89 11.65 13.05 9.80
11.73 7.16
121.80 132.00 139.60 115.40 135.00 155.30 126.10 151.80 165.70 147.10
1138 1177 1040 899 1192 RNV 860 687 1164 1072
8.61 12.58 5.94 12.09 6.69 10.04 11.50 12.78 8.70 6.95
180.60 133.10 194.80 143.40 147.70 162.90 163.20 184.30 98.20 143.10
1039
1274
RNV RNV
1220
1177
1065 RNV
1112
1219
8.41 8.69
14.43
12.22
9.18 13.19 8.94 10.59
7.10 12.94
)
DuPont-9478
Company Sanitized. Does not contain TSCA C8I
566
90, _-D_ay Oral Gavage StuidSyubinchRraotnsic Toxicity
)
Animal Number
COND
RBC x 106/m L
gH/GdBh
HCT %
Female, Group VIII - 25 mg/kg/day - Day 94
655011 655012 655047
655055
655058 655073 655076 655078 655085 655105
OK OK OK OK
OK OK
OK OK OK OK
7.30 7.92 7.78
7.56 8.49 8.09 8.40 8.49 8.74 7.90 '
14.6 15.4 15.5 15.1 16.5 15.5 16.1 15.9 16.8 15.9
42.3 44.4 .44.7
43.3 48.6 46.0 46.4 48.1 49.7 44.2
Female, Group X - 125 mg/kg/day - Day 94
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
OK OK OK OK OK OK OK OK OK OK
8.11
7.87 7.90 7.30 7.56 7.55 8.14 7.08
7.53 7.56
15.3 15.9 15.9 14.4 15.6 14.6 15.8 13.7
14.9 15.3
45.9 46.9 46.1 42.5 46.2
42.5 46.6 40.6 43.8
45.2
Individual Hematology Values MCV MCH MCHC RDW fL P9 g/dL %
ARET
PLT
WBC
xl03/jL x 103/m L x 103/m L
57.9 56.1 57.4 57.3 57.2 56.9 55.2 56.6 56.9 56.0
20.0
19.5
19.9
19.9 19.4 19.1
19.2 18.7 19.2
20.2
34.4 34.8 34.7 34.7 34.0 33.6 34.7 33.1 33.8 36.0
11.1 10.6
10.5
10.8
10.4
10.6 10.8
11.4
11.3
10.8
170.40 130.00 120.70
139.70 133.30 151.80 153.10 164.20 137.80 105.30
1057 1321 811 RNV 1042
RNV 1204 824 923 RNV
10.13 10.27 12.05
7.43 13.41 8.51 8.30 8.77 13.87 5.81
56.5 59.6 58.4 58.3 61.1 56.2 57.2 57.3
58.2 59.8
18.8
20.2 20.1
19.8
20.7
19.3
19.4
19.3
19.8
20.3
33.3 33.9 34.4 33.9 33.9 34.4 34.0 33.7
34.1 33.9
11.2 12.1 11.0 10.8
11.4
11.2 12.0
12.4
11.8 11.6
145.40 185.00 151.90 136.80 148.00 131.90 240.90
223.70 195.90 206.80
1214
962 RNV 1186 1037
1112
1061
980 1060
997
11.74 7.21 9.29 9.71 11.18 10.25 11.77 9.69 11.15 10.59
>
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
567
Company Sanitized. Does not contain TSCA CBI
90-Day Oral G_a_va_ge SJtudSyubinchRroatnsi_c_T__o_x_ic_ity
)
Animal Number
X lA0N3E/U h
x lA0L3Y/M h
AMON X103/ML
AEOS x 103/m L
Female, Group II - 0 mg/kg/day - Day 94
Individual Hematology Values
ABAS
ALUC
xl03/iiL xl03/nL
655031 655016 655025 655032 655036 655079
655083 655098 655099 655107
1.29
0.88 1.21
2.07
0.52
1.70
1.20
1.37
1.75
0.84
-
11.28 5.21 6.42 16.57 7.02 9.46
11.36 8.06 9.36
6.00
0.19
0.13 0.14
0.34 0.15
0.22
0.17
0.12
0.25
0.11
0.29
0.13
0.15
0.26
0.11 0.12
0.23 0.17
0.22 0.11
Female, Group IV - 1 mg/kg/day - Day 94
0.05
0.02
0.04
0.10
0.04
0.07
0.05 0.05
0.08
0.06
0.06 0.04 0.04 0.18 0.04 0.07 0.04 0.04 0.08 0.03
655013 655033
655040 655041 655044
655086 655089 655090 655091 655108
0.76
1.47
0.47 3.09 0.82
1.08
0.88
1.43
0.88
2.29
7.49 10.50 5.27 8.40 5.55 8.41 10.19 10.85 7.52 4.35
0.11
0.29
0.09 0.33 0.18 0.15 0.18 0.25
0.08
0.11
0.09 0.18 0.08 0.13 0.09 0.16 0.15 0.16 0.15
0.12
0.08 0.07
0.01
0.07 0.04
0.14 . 0.05
0.05
0.03 0.06
0.07
0.08
0.02
0.07
0.02 0.11
0.05
0.04
0.04
0.02
Female, Group VI - 5 mg/kg/day - Day 94
655020
655029 655034 655038 655039 655042 655054 655066 655067 ' 655087
1.38
1.22
1.15
1.10
2.34
1.99
1.20
2.16
1.02
0.98
6.65
6.88
12.70
10.88
6.60
10.74 7.28 8.08 5.74
11.42
0.06
0.26
0.29
0.12
0.09
0.19
0.10
0.09
0.10 0.21
0.24
0.17 0.29
0.12
0.07
0.16
0.13 0.13 0.19
0.20
0.05
0.10 0.00 0.00
0.03
0.06
0.16
0.05
0.02
0.06
0.03
0.06
0.00 0.00
0.04
0.06
0.07
0.06 0.03
0.06
-568-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
( *90-DaBy BOrBalHGHavBagPeQStsuudbycihnrRoantsic Toxicity
)
Animal Number
ANEU
ALYM
AMON
AEOS
xl03//L xl03/f(L xl03/L X103/ML
Female, Group VIII - 25 mg/kg/day - Day 94
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
1.94
0.47
1.93
1.08 1.29
2.21
0.82
1.68
4.87
1.29
7.70 9.32 9.58 . 5.98 11.59 6.13 7.17 6.71 7.78 4.14
0.29 0.14
0.26
0.18 0.15 0.08
0.10
0.13 0.81 0.14
0.13
0.21
0.09
0.11
0.15
0.09
0.06
0.15
0.25.
0.21
Female, Group X - 125 mg/kg/day - Day 94
655007
655023 655026 655052 655053 655063 655092 655095 655097 655103
2.29
1 .01'
0.76 1.69 1.64 1.51 1.92 1.90 1.44 3.21
8.76 5.81 7.92 7.45 9.19 8.44 9.35 7.36 8.99 6.87
0.38
0.20
0.31
0.31
0.16
0.10
0.26 )
0.22
0.37
0.28
0.21
0.13
0.19
0.10
0.09
0.09 0.14 0.09
0.18
0.12
Individual Hematology Values
ABAS
ALUC
X103/ML xl03//iL
0.03
0.06 0.08
0.04
0.12
0.00 0.09 0.06 0.07
0.02
-
0.04
0.06
0.10
0.04
0.10
0.00
0.06 0.04
0.09
0.01
0.05
0.03 0.05
0.10
0.04 0.05 0.05 0.06 0.08
0.06
0.04
0.03 0.05 0.06 0.06 0.05 0.05 0.05 0.09 0.05
-569-
)
DuPont-9478
90-Day Oral G_a_v_a_g_e_S_tfuSduybicnhrRoantisc Toxicity
Animal Number
COND
RBC xl06//iL
HGB g/dL
HCT %
Female, Group II - 0 mg/kg/day - Day 183
655009 655015 655019 655035 655062 655068 655072 655101 655109
OK OK OK OK OK OK OK OK OK
8.46 7.47 7.32 7.90 7.43 7.49 7.92
8.01
7.81
16.0 13.8 14.7 15.1 14.2 14.9
14.4 14.9 14.3
47.7 ^41.6 43.7 44.7 43.0 44.4 43.4 44.9 42.8
Female, Group X - 125 mg/kg/day - Day 183
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
OK OK OK
OK OK OK OK OK OK OK
7.76
7.59
8.07
7.93 7.63
7.57
8.22
7:84 7.78
7.12
15.1 ' 15.0
15.4 15.2 14-7 14.8 15.4 15.6 15.4
13.9
45.5 44.2 47.0 45.4 42.6 45.3 47.4 45.8 46.0 41.4
Individual Hematology Values
MfChV
MCH
pg
MCHC g./dL
RDW %
ARET X103/ML
PLT xl03/iiL
WBC x 103/r L
56.3 55.7 59.7 56.6 57.9 59.3 54.8 56.1 54.8
18.9 18.4
20.1
19.1 19.1 19.9
18.2 18.6 18.3
33.6 33.1 33.6 33.8 33.0 33.5 33.1 33.2 33.4
11.2 11.8
12.4
12.5
12.0
11.3
12.0 11.1
11.7
111.60 144.80 158.50 216.50 188.40 169.50 123.40 135.70 132.90
956 RNV RNV 1357 861 877
999 1283 1082
11.29 6.67 8.98 6.56 4.32 5.84 7.73 7.24 6.94
58.6 58.2 58.2 57.3 55.9 59.8 57.7 . 58.5 59.1 58.2
19.5 19.7 19.0 19.2 19.3 19.5 18.8 19.9 19.7
19.6
33.3 33.8 32.7 33.5 34.5 32.7 32.6 34.0 33.4 33.6
1 2 ,.6 13,.0
1 2 ,.5 1 1 ,.2 1 1 ,.1 1 2 ,7 1 1 ,.6 1 1 .4 1 1 ,.9 13.,1
213..60
138..20 183..00
183..40
,133..10 162..00 179..10
150..60
128..30
172..70
RNV 761 1026 1191 1250 RNV RNV 786 726 RNV
8.39
7. 79
7..54
8 ..26 7. 11
9. 99
6.18
9. 13
11 .63
5. 92
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
570
Company Sanitized. Does not contain TSCA CBi
90-Day Oral Gavage SMtudSyuibnchRraotnsic Toxicity
Animal Number
ANEU xl03//iL
ALYM x l 0 3 /tfL
AMON xl03/aL
AEOS xl03/iiL
Individual Hematology Values
ABAS
ALUC
xl03/fiL x 1 0 3 / zL
Female; Group II - 0 mg/kg/day - Day 183
655009 655015 655019 655035 655062 655068 655072 655101 655109
2.23 1.29 1.35 1.09 0.79 1.46 0.63 1.85 1.24
8.45 5.09 7.21 5.11
3.26 3.77 6.75 5.06 5.28
,
0.40
0.14
0.22
0.19
0.19 0.44
0.11 0.21
0.31
0.11 0.11
0.14
0.11
0.04
0.10
0.07
0.08
0.05
0.06
0.01
0.04
0.04
0.03 0.04
0.13
0.02
0.03
0.04
0.03
0.03
0.03
0.02 0.02
0.03
0.02
0.03
Female, Group X - 125 mg/kg/day - Day 183
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
2.33
1.53
1 .12 .
2.14'
1.20
1.61
1.11 1.11 1.22
0.96
5.22 5.81
6.10
5.84 5.40 7.74 4.61 7.61 9.87
4.48
0.58 0.19 0.17 0.17 0.32 0.42 0.18 0.23 0.30 0.35
0.16 0.15 0.07 0.06 0.09 0.09 0.19 0.07 0.15 0.07
0.07 0.07 0.06 0.04 0.04 0.08 0.07 0.06 0.07 0.04
0.03
0.03
0.02 0.02
0.05
0.04
0.01
0.04
0.03
0.02
571
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
90-Pay Oral Gavage Stu^dSyuibnchRraotnsic Toxicity
)
Animal Number
NORM
ANIS
MIC
Male, Group I - 0 mg/kg/day - Day 48
654903 654925 654928 654929
654936 654950 654953 654972 654987 654993
'
NO NO NO NO
NO NO NO NO NO NO
-
-
-
_
-
-
-
-
Male, Group III - 1 mg/kg/day - Day 48
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
NO NO NO NO NO NO NO NO NO NO
_
TRACE. -
-
_
TRACE -
-
-
Male, Group V - 5 mg/kg/day - Day 48
654907 654911 654916 654917 654959 654961 654967 654980
654998 655005
NO NO NO NO NO NO NO NO NO NO
_ -- ._ ---
--
--
-
-
--
Individual Red Blood Cell Morphology Values
MAC
POLY
HYPO
ECHI
ACAN
TARG
_ TRACE
_
_ FEW _
- TRACE -
- FEW -
- TRACE
-
FEW FEW
-
- TRACE
~
TRACE
TRACE
-
- TRACE
-
- FEW -
- TRACE
-
-
-
-
- TRACE - TRACE
- - MODERATE -
_
TRACE
FEW
-
- TRACE -
- FEW -
- TRACE
-
TRACE
FEW
~
- TRACE
-
FEW TRACE
-
- TRACE
-
FEW -
- TRACE
-
-
-
FEW
-
TRACE
FEW
-
- TRACE
-
- TRACE
-
- TRACE -
~ FEW
-
- TRACE
-
-
-
-
- TRACE -
-
-
-
TRACE
-
- MODERATE
-
-
TRACE
.-
-
-
-
_ TRACE -
_ TRACE -
- TRACE
-
- TRACE
-
- TRACE
-
- FEW -
- TRACE -
- MODERATE
-
- TRACE - - - -
- TRACE -
- MODERATE -
- TRACE -
FEW MODERATE
-
-
TRACE
-
TRACE
FEW
-
- TRACE -
--
-
-
TRACE
-
TRACE
TRACE
-
RX
`_
-
~ ~
_ -
-
-
-
_
HJB
-
-
-
-
-
-
-
-572-
)
DuPont-9478
90-Day Oral Uavage 'tudSyubinchRraotnsic Toxicity
Individual Red Blood Cell Morphology Values
Animal Number
NORM
ANIS
MIG
MAC
PONY
HYPO
ECHI
ACAN
TARG
RX
HJB
Male, Group VII - 25 mg/kg/day - Day 48
654922 654923
NO NO
_ _
-
- TRACE
_
_ MODERATE
--
-
TRACE
-
TRACE
FEW
-
-
-
654930
NO
-
-
- TRACE
-
TRACE
FEW
-
-
-
, 654940
NO
-
-
- FEW -
- MODERATE . -
-
-
654952
NO
~
- TRACE
-
- FEW -
-
-
654958
NO
-
-
- TRACE
-
FEW Many
-
-
654975
NO
-
_
- TRACE
-
- TRACE
~
-
-
654989
NO
-
-
- TRACE
-
-
-
-
-
-
655001
NO
-
-
- TRACE
- FEW -
-
-
655006
NO
-
-
- TRACE
-
-
-
-
-
Male, Group IX - 125 mg/kg/day - Day 48
654914
NO
_
- TRACE
_
_ MODERATE -
-
-
654921
NO
-
-
-
TRACE
-
- MODERATE
-
-
-
654951
NO
-
-
- TRACE
-
- FEW -
-
-
654955
NO
-
-
- TRACE
-
FEW FEW
-
-
-
654965
NO
-
-
- TRACE
-
TRACE MODERATE
-
-
-
654979
NO
-
-
- FEW
-
- TRACE
-
-
-
654983
NO
-
-
- TRACE
-
-
-
-
_
-
654986
NO
_
-
- TRACE -
-
-
-
-
-
654996
NO
-
-
-
TRACE
-
FEW MODERATE
-
-
655003
NO
-
-
-
TRACE
-.
- MODERATE -
-
-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-573-
C r'tyuSdyubinchRraotnsic Toxicity
)
Animal Number
NORM
ANIS
MIC
Male, Group I - 0 mg/kg/day - Day 93
6549Q3
NO
-
-
654925
NO
-
-
654928
NO
-
-
654929
NO
_
-
654936
NO
-
-
654950
NO
-
-
654953
NO
-
-
654972
NO
-
-
654987
NO
-
-
654993
NO
"
-
Male, Group III - 1 mg/kg/day - Day 93
654908 654913 654932 654938 654941
654946 654947 654960 654984 654995
NO NO NO NO NO NO -
NO ,
NO NO -
NO -
-
-
-
-
-
Male, Group V - 5 mg/kg/day - Day 93
654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
NO NO NO NO NO NO NO NO NO NO
- -
--
--
--
-----
Individual Red Blood Cell Morphology Values
MAC
POLY
HYPO
ECHI
ACAN
TARG
_ TRACE
- TRACE - TRACE
- TRACE
- TRACE
- TRACE - TRACE - TRACE - TRACE
- TRACE
- MODERATE
-
-
MANY
TRACE
- MANY
-
- TRACE -
- FEW
-
- TRACE
-
-
MANY
TRACE
-
TRACE
FEW
- MODERATE TRACE
-
MANY
TRACE
_ -
-
_ TRACE
- TRACE - TRACE ~ TRACE - TRACE
- TRACE - TRACE
- TRACE
- TRACE
- TRACE
- MODERATE TRACE
-
MANY
TRACE
---
- MODERATE
-
-
TRACE
TRACE
-
MANY
TRACE
- FEW
--
-
-
-
MANY
FEW
- TRACE -
-
-
-
-
_ TRACE
TRACE
- TRACE
- TRACE
TRACE
- TRACE - TRACE - TRACE - TRACE
- TRACE
FEW _
- MODEIUtTE -
- MODERATE TRACE
- MODERATE TRACE
- MODERATE TRACE
-
MANY
TRACE
-
MANY
FEW
- . MANY TRACE ---
-
MANY
TRACE
-
-
-
RX HJB
_
-
-
-. -
-
_ -
-
-
-
--
--------- TRACE
-
-
-
< -
-' -
-
-
)
DuPont-9478
Company Sanitized. Does not contain TSCA C8I
-574-
j Subchronic Toxicity 90-Day Oral Gavage Study in Rats
Animal Number
NORM
ANIS
MIC
Individual Red Blood Cell Morphology Values
MAC
POLY
HYPO
ECHI
ACAN
TARG
Male, Group VII - 25 mg/kg/ay - Day 93
654922 654923 654930 654940 654952
654958' 654975 654989 655001 655006
NO NO NO NO NO
NO NO NO NO NO
~
' -
-
_
-
-
_
-
-
TRACE TRACE TRACE TRACE TRACE
TRACE TRACE TRACE TRACE TRACE
MANY
TRACE
- MODERATE TRACE
-
. MANY
TRACE
- MODERATE TRACE
-
MANY
TRACE
~
MANY
TRACE
-
MANY
TRACE
---
- MODERATE TRACE
- TRACE
-
_
-
-
-
-
Male, Group IX - 125 xag/kg/day - Day 93
654914 654921 654951 654955 654965 .654979 654983 654986 654996 655003
NO NO NO NO NO NO NO NO NO NO
_
--FEW FEW ----FEW FEW --
-
-
TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE TRACE
_
MANY
FEW
-
MANY
TRACE
-
- MODERATE TRACE
-
-
MANY
FEW
-
-
MANY
TRACE
-
-
MANY
TRACE
-
- MANY
-
~
-
MANY
TRACE
-
- MODERATE MODERATE
-
-
MANY
TRACE
-
RX
_
-
' -
_ -
HJB
_
-
-
-
_
_
-
-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-575-
90-Day Oral Gavag_e_SJtSuudbycihnroRnaitcs Toxicity
)
Individual Red Blood Cell Morphology Values
Animal Number
NORM
ANIS
MIC
MAC
POLY
HYPO
ECHI
ACAN
TARG
ale, Group I - 0 mg/kg/day - Day 183
654909
NO
-
-
654910
NO
-
_
654915
NO
-
-
654924
NO
-
~
654927
NO
-
-
654943
NO
-
-
654949
NO
-
-
654956
NO
-
-
654992
NO
-
-
654994
NO
_
-
-
TRACE TRACE TRACE TRACE TRACE TRACE
FEW TRACE TRACE TRACE
_
TRACE MODERATE
_
- MODERATE MODERATE -
MANY
FEW
-
-
FEW MODERATE
-
- MODERATE MANY
-
-
FEW MODERATE
-
- MODERATE MODERATE
- FEW FEW -
- MODERATE MODERATE -
MODERATE MODERATE
ale. Group IX - 125 mg/kg/day - Day 183
654942
NO
_
_
_ TRACE _ MODERATE MODERATE _
654957
NO
-
-
- TRACE - MODERATE MANY
-
654973
NO
-
-
TRACE
-
FEW MODERATE
-
654974
NO
-
-
- TRACE -
FEW MODERATE
-
654976
NT
NT
NT
NT
NT
NT
NT
NT
NT
654977
NO
-
-
- TRACE -
FEW MODERATE
-
654978
NT
NT
NT
NT
NT
NT
NT
NT
NT
654985
NT
NT
NT
NT
NT
NT
NT
NT
NT
654990
NO
-
-
- TRACE - MODERATE FEW
-
654991
NO
-
-
- TRACE
MODERATE FEW
-
RX HJB
_-
- TRACE
---
--' ----
TRACE
_----
NT NT
--
NT NT NT NT
---
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-576-
Company Sanitized. Does not contain TSCA CBI
90-Day Ora avage StudSyubinchRraotnsic Toxicity
Animal Number
NORM
ANIS
MIC
Individual Red Blood Cell Morphology Values
MAC
POLY
HYPO
ECHI
ACAN
TARG
RX
HJB
Female, Group II - 0 mg/kg/day - Day 49
655016
NO
_
_
_ FEW
_ FEW
_
_
_
_
655025
NO
-
- - TRACE - - _ - - _
655031
NO
_
_
- TRACE -
- TRACE -
-
-
655032
NO
-
-
- TRACE
-
- TRACE _
-
-
655036
NO
-
-
- TRACE - MODERATE FEW
-
-
-
655079
NO
-
-
- TRACE
-
_ FEW _
_
-
655083
NO
-
-
- TRACE
-
_
_
_
_
-
655098
NO
-
-
- TRACE
-
_ TRACE
-
-
-
655099
NO
-
-
- TRACE
-
-
-
-
-
-
655107
NO
-
-
- TRACE
-
-
-
-
-
-
Female, Group IV - 1 mg/kg/day - Day 49
655013
NO
_
_
- TRACE
_
_ FEW
_
_
_
655033
NO
-
-
- TRACE
-
TRACE
FEW
-
-
-
655040
NO
-
-
- TRACE
-
TRACE MODERATE
-
-
655041
NO
-
-
- TRACE
-
- FEW -
-
-
655044
NO
-
-
- TRACE - -
-
-
-
-
655086
NO
-
-
- TRACE
-
TRACE
FEW
-
-
-
655089
NO
-
~.
-
TRACE
-
-
FEW
-
--
655090
NO
-
-
- FEW - - FEW - - -
655091
NO
-
-
- TRACE
-
FEW FEW.
-
-
-
655108
NO
-
-
-
TRACE.
-
TRACE
TRACE
-
-
-
Female, Group VI - 5 mg/kg/day - Day 49
655020
NO
_'
_ TRACE
- TRACE
_
_
-
-
655029
NO
-
-
- FEW -
-
-
-
-
-
655034
NO
-
-
TRACE
-
-
---
655038
NO
-
- TRACE
-
- FEW -
-
-
655039
NO
-
-
- TRACE - TRACE -
-
-
-
655042
NO
TRACE
TRACE
-
TRACE
-
- FEW -
-
-
655054
NO
-
-
- TRACE -
FEW MODERATE
-
-
-
655066
NO
-
-
- TRACE
- --
--
655067
NO
-
-
- TRACE -
FEW FEW
-
-
-
655087
NO
- - TRACE - - _ - - _
-577-
)
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
Individual Red Blood Cell Morphology Values
Animal Number
NORM
ANIS
MIC
MAC
POLY
HYPO
ECHI
ACAN
TARG
RX
HJB
Female, Group VIII - 25 mg/kg/day - Day 49
655011
NO
-
-
- TRACE
-
FEW FEW
-
-
-
655012
NO
-
_
- TRACE
-
-
-
-
-
-
655047
NO
-
-
- TRACE -
-
-
-
--
655055
NO
-
-
-
FEW
-
TRACE MODERATE
-
-
-
655058
NO
-
-
- TRACE
-
TRACE
TRACE
-
-
-
655073
NO
- TRACE
- MODERATE FEW
-
-
-
655076
NO
-
-
- TRACE
- TRACE
-
-
-
-
655078
NO
-
-
- TRACE
_
-
-
-
-
-
655085
NO
-
-
- TRACE -
- TRACE -
-
-
655105
NO
-
-
- TRACE
-
- FEW -
-
"
Female, Group X - 125 mg/kg/day - Day 49
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
NO NO NO NO NO NO NO NO NO NO
TRACE -
TRACE -
TRACE -
-, TRACE
-
~ -
_ TRACE - TRACE - TRACE - TRACE - TRACE - TRACE - . TRACE - TRACE - TRACE
- TRACE
_ FEW FEW
- FEW FEW
-
MODERATE
FEW
-
TRACE
TRACE
- - FEW
- - TRACE
---
- MODERATE MODERATE _ FEW FEW
- - TRACE
_
-
-
_-
--
----
---
---
- .-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
-578-
Company Sanitized. Does not contain TSCA CBI
90-Day Oral Gavage SJtuijdSyubinchRraotnsic Toxicity
)
Animal Number
NORM
ANIS
MIC
Individual Red Blood Cell Morphology Values
MAC
POLY
HYPO
ECHI
ACAN
TARG
Female, Group II - 0 mg/kg/day - Day 94
6550:16
NO
_
_
655025
NO
-
-
655031
NO
-
-
655032
NO
-
-
655036
NO
-
-
655079
NO
-
-
655083 655098
NO NO
-
_
655099
NO
-
-
655107
NO
-
-
Female, <Group IV - 1 mg/kg/day - Day 94
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
NO NO NO NO NO NO ~
NO .
NO NO -
NO -
_ _
-
-
-
Female, Group VI - 5 mg/kg/day - Day 94
_
-
-
-
-
_ -
-
-
-
FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW
FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW
_ MODERATE _
- FEW -
- MODERATE
-
- FEW FEW
-
MANY
TRACE
-
FEW-
TRACE
- MODERATE TRACE
- MODERATE TRACE
- FEW -
---
_
MANY
TRACE
- FEW FEW
-
MANY
FEW
- MODERATE - FEW
-
- FEW -
- FEW -
- MODERATE FEW
-
MANY
FEW
- MODERATE -
_
-
-
-
_ -
_ _ _
-
-
-
655020 655029 655034
655038 655039 655042 655054 655066 655067 655087
NO NO NO NO NO NO NO NO NO NO
_
_
--
----
--
---
-
-~
_ FEW _
__
- FEW - FEW -
-
- FEW -
--
- FEW - MODERATE -
-
- FEW - MANY -
-
- FEW ~
- FEW -
- FEW - MANY -
FEW
-
FEW TRACE
-
-
FEW
-
MODERATE
FEW
-
- FEW - - - -
RX
_
-
-
-
_ -
-
-
-
_
-
HJB
_
-
-
-
_ -
.-
-
-
-
-
-
_ -
-579-
DuPont-9478
90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity
Individual Red Blood Cell Morphology Values
Animal Number
NORM
ANIS
MIC
MAC
POLY
HYPO
ECHI
ACAN
TARG
RX
HJB
Female, Group VIII - 25 mg/kg/day - Day 94
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
NO NO NO NO NO NO NO NO NO NO
-
-
-
-
-
FEW
-
MANY
TRACE
-
- FEW -
FEW
FEW '
-
---
- FEW - FEW -
--
-
-
FEW
-
MANY
TRACE
-
-
-
-
FEW
- MODERATE
-
---
- FEW
MANY
FEW
~
-
-
- FEW
- FEW
-
-
--
- FEW - - - - - -
- FEW - MODERATE FEW * - "
-
FEW , " MODERATE TRACE
-
-
-
Female, 1Group X - 125 mg/kg/day - Day 94
655007 655023 655026 655052 655053 655063 655092 655095 655097
655103
NO NO NO NO NO NO NO NO NO NO
-
-
-
FEW MANY
-
FEW
_
MANY
FEW
-
-
-
-
FEW
-
MANY
-
-
-
-
-
FEW -
FEW
-
-
-
-
-
FEW
-
MANY
TRACE
-
-
-
-
FEW
-
MANY
FEW
-
-
-
FEW- - - - - - -
-
FEW
-
MANY MODERATE
-
-
-
-
FEW
-
MANY
FEW
-
-
-
-
FEW
-
MANY
FEW
-
-
-
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-580-
C 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
Individual Red Blood Cell Morphology Values
Animal Number
NORM
ANIS
MIC
MAC
POLY
HYPO
ECHI
ACAN
TARG
RX
HJB
Female, Group II - 0 mg/kg/day - Day 183
655009
NO
_
_
_ TRACE
TRACE
TRACE
_
_
_
655015
NO
~
~
- TRACE
-
TRACE
TRACE
-
-
-
655019
NO
-
-
- TRACE
-
TRACE
FEW
-
-
-
655035
NO
-
-
- TRACE
-
TRACE
TRACE
-
-
-
655062
YES
-
-
--
-
----
-
655068
NO
-
-
- TRACE
-
TRACE
TRACE
-
-
655072
NO
-
-
- TRACE
-
FEW FEW
-
--
655101
NO
-
_
-
TRACE
-
TRACE
TRACE
-
-
-
655109
NO
-
-
- TRACE
- MODERATE TRACE
-
-
-
Female, Group X - 125 mg/kg/day - Day 183
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
NO NO NO NO NO NO NO NO NO NO
_
.-
-
,-
__
-----
- -----
TRACE TRACE TRACE TRACE TRACE TRACE TRACE , TRACE TRACE TRACE
_
MANY
MANY
_
-
FEW TRACE
-
FEW MODERATE .-
----
----
-
TRACE
TRACE
-
-
MODERATE
FEW
-
- TRACE
-
-
- MODERATE MODERATE
-
- MODERATE MANY
-
_-
_---- ,--
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-581 -
Company Sanitized. Does not contain TSCA CBI
~90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Male, Group I - 0 mg/kg/day - Day 48
654903
YES
_
__
__
_
654925
YES
-
-----
654928
YES
-
--
- - --
654929
YES
- _ - -'
--
654936
NO
-
-
- YES/ADEQ
-
-
654950
YES
-
-- - - --
654953
NO
-
-
-
- YES/ADEQ
-
-
654972
NO
-
- - - YES/DECK - -
654987
YES
-
-----
654993
NO
-
-
-
- YES/ADEQ
-
-
Male, Group III -- 1 mg/kg/day - Day 48
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
NO YES YES NO NO NO NO NO YES YES
-
-
-
_ -
_
_ YES/ADEQ
-
-- - - --
------
--
YES/ADEQ
-
-
--
- YES/ADEQ -
-
-
-
- YES/ADEQ
-
-
-
- YES/UTD
-
-
-
-
,, YES/ADEQ
-
-
------
------
Mal'e, Group V - !5 mg/kg/day - Day 48
654907 654911 654916 654917 654959 654961 654967
654980 654998 655005
YES NO NO YES NO YES YES YES YES YES
_ -
-
_ ---
-
-
- YES/ADEQ
-
-
-
-
- YES/ADEQ
-
-
-- - - --
-
-
- YES/UTD
-
-
------
------
------
--
-
-
-
-
-
-582-
)
DuPont-9478
90-Day Oral _G_a_v_a_g_e_SStuubdcyhrionnRicatTsoxicity
Animal Number
NORM
SM
Individual White Blood Cell / Platelet Morphology Values TOX DB VC BC PCE GP BP
Male, Group VII - 25 mg/kg/day - Day 48
654922
YES
-
-
-
-
-
-
-
-
654923
YES
-
-
-----
654930
NO
-
-
-
-
- YES/ADEQ
-
-
654940
NO
-
-
-
-
- YES/ADEQ
~
-
654952
NO
-
-
-
-
- YES/ADEQ
-
-
654958
NO
-
-
-
-
- YES/DECR
-
-
654975
YES
-
--
-
-
-
-
654989
NO
-
-
-
-
- YES/ADEQ
-
655001
YES
-
-
-----
655006
YES
-
-
-
-
-
-
-
-
Male, Group IX - 125 mg/kg/day - Day 48
654914 654921 654951 654955 654965 654979 654983 654986
654996
655003
YES NO NO YES NO NO YES YES
YES NO
_
-
-
-
-
_
-
-
-
-
-
_
-
-
-
-
-
-
. _ -
-
-
-
-
-
, -
_
YES/UTD
YES/DECR -
YES/ADEQ
YES/ADEQ
-
-
-
YES/UTD
-
-
-
-
-
-
" -
-
J
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-583-
Company Sanitized. Does not contain TSCA CBI
_9_0_-D__a_y_O__r_a_l _G_avage StJudSyubinchRraotnsic Toxicity
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Male, Group I - 0 mg/kg/day - Day 93
654903
YES
_
,,
_
_
_
_
_
_
654925
YES
-
-
_
-
_
_
_
_
654928
YES
-
~--_ _-
654929
YES
-
-
--- -
654936
YES
-
-
-
-
-
-
_
-
654950
YES
-
-
_
-
-
-
-
-
654953
YES
--
-- --
654972
NO
-
-
-
-
- YES/DECR
-
-
654987
YES
-
-
-
-
-
-
~
-
654993
YES
-
-
- - -
Male, Group III -- 1 mg/kg/day - Day 93
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
YES _ YES YES YES YES NO NO . YES -
NO -
YES -
_ -
-
_
-
_
-
-,
_
-
-
-
-
__
----- YES/DECR - YES/DECR -_ YES/ADEQ
_
_ -
-
~ -
-
-
~ -
Male, Group V - 5 mg/kg/day - Day 93
654907
YES
_ _
_
-_
__
_
654911
YES
-
-
-
-
-
-
-
-
654916
NO
-
-
-
-
- YES/ADEQ
-
-
654917
YES
-
-
-
-
-
-
-
-
654959
YES
-
-
-
-
-
-
_
~
654961
YES
-
-
-
-
-
-
-
654967
YES
-
-
-
-
-
-
-
-
654980
YES
-
-
-
-
-
-
-
-
654998
YES
-
-
-
~
-
_ -
-
655005
NO
-
-
_
_
- YES/ADEQ
-
-
-584-
DuPont-9478
90-Day Oral Gavage StudSyubinchRraotnsic Toxicity
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCS GP
BP
Number
Male,' Group VII - 25 mg/kg/day - Day 93
654922
YES
_
_
_
_
__
654923
YES
-
-
-
-_
-
--
654930
YES
-
-
-
-
-
-
-
-
654940
YES
-
-
- --
--
654952
YES
-
-
---
-
--
654958 654975
YES NO
-
-
-
-
-
-
-
--
YES/ADEQ
-
-
654989
NO
-
-
-
-
- YES/DECK
-
-
655001
YES
-
-
-
-
-
-
-
-
655006
YES
,_
-- - - - - -
Male, Group IX - 125 mg/kg/day - Day 93
654914 654921 654951 654955 654965 654979 654983 654986 654996 655003
YES YES YES YES YES YES YES YES NO YES
_
-
-
-
-
-
_
-
'
-
" -
__
-- -~---
--
--
-
--
--
- YES/ADEQ -
-- -
_
-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CB1
-585-
'90-Day Oral Gavage StuidSyubinchRraotnsic Toxicity
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
Number
BC
PCE GP
BP SPEC
Male, Group I - 0 mg/kg/day - Day 183
654909
NO
YES/UTD
654910
NO
-
~-
YES/ADEQ
654915
YES
-
-
654924
NO
-
-
YES/UTD
654927
YES
-
-'
654943
YES
-
-
654949
YES
-
-
654956
YES
-
-
654992
NO
-'
- - - YES/UTD
654994
YES
-
-
TRACE- SPHEROCYTE
Male, Group IX - 125 mg/kg/day - Day 183
654942
YES
-
_
--
---
654957
YES
-
-
-
-
_
--
-
654973
YES ,
-- - _ - - -
654974
YES
-
-
-
--
-
-
654976
NT
NT
NT
NT
NT
NT
NT
NT
NT
654977
YES.
-
-'
-----
654978
NT
NT
NT
NT
NT
NT
NT
NT
NT
654985
NT
NT
NT
NT
NT
NT
NT
NT
NT
654990
YES -
-
-
-
-
-
---
654991
YES
-
-
-
_
----
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-586-
Company Sanitized. Does not contain TSCA CB)
( L90-Day Oral Gavage Study in Rats Toxicity
)
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Female, Group II - 0 mg/kg/day - Day 49
655016
NO
-
-
-
-
- YES/UTD
-
-
655025
YES
-
-
-
-
-
-
-
-
655031
YES
-
-
-
-
-
-
-
-
655032
YES
-
~
-
-
-
-
-
-
655036
NO
-
--
-
- YES/ADEQ
-
-
655079
YES
-
-
-
-
-
-
-
-
655083
YES
_
-
-
-
-
-
-
-
655098
YES
-
-
-
----
655099
YES '
_
-----
655107
NO
-
-
-
-
- YES/ADEQ -
-
Female, Group IV - 1 mg/kg/day - Day 49
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
YES YES YES YES YES YES NO YES NO NO
_
-
-
_
-
-
-
_
__
---
----
----
----
---
-
- YES/ADEQ
-
.- - -
-
- YES/ADEQ
-
-
- YES/UTD
-
_ -
-
Female, Group VI - 5 mg/kg/day - Day 49
655020
YES
_
-_
_
-
-
-
-
655029
YES
----
--
655Q34
YES
-
-
-
-
-
-
-
-
655038
YES
-
-
-
-
-
-
-
-
655039
YES
-
-
-
-
-
-
-
-
655042
YES
-
-
-
-
-
-
-
-
655054
YES
-
-
-
-
-
-
-
-
655066
NO
-
-
-
- YES/ADEQ
-
-
655067
YES
-
-
-
-
-
-
-
-
655087
NO
-
-
-
- YES/UTD
-
-
-587-
)
DuPont-9478
_90-Day_O__ra_l_Gavage Stu_dSyuibnchRraotnsi_c_T__o_x_i_ci_t_y
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Female, Group VIII - 25 mg/kg/day - Day 49
655011
YES
-
-
-
655012
YES
-
-
655047
YES
-
--
655055
YES
-
-
-
655058
NO
-
-
-
655073
NO
-
-
-
655076
YES
-
-
-
655078
YES
-
-
-
655085
YES
-
~
-
655105
YES
-
-
-
Female, Group X - 125 mg/kg/day - Day 49
655007
NO
-
--
655023
YES
-
655026
NO
-
-
-
655052
YES
-
-
-
655053
NO
-
-
-
655063
YES
-
-
-
655092
YES
-
-
655095
NO
-
-
_
655097
YES
-
_
-
655103
NO
-
-
-
-
_
-
. -
-
---
_-
--
- YES/ADEQ - YES/ADEQ -----
-
-
_
-
-
_ YES/ADEQ _ --- YES/INCR -
-- -
- YES/UTD -
---
---
- YES/DECK -
--
- YES/DECR -
-
-
-
_
-
-
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-588-
Company Sanitized. Does not contain TSCA CBI
1L90-Day
ISubchronic Toxicity irai (Savage Study in Rats
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Female, Group II - 0 mg/kg/day - Day 94
655016
YES
_
-
____
655025
YES
-
-- -
-
---
655031
YES
-
---_
655032
YES
-------
655036
YES
-
-
-
-
-
-
-
-
655079
YES
-
-
-
-
-
-
-
-
655083
YES
-
-
-
-
-
-
-
~
,655098
YES
-
-
-
-
---
655099
YES
-
-
-
-
-
-
-
-
655107
YES
-
- *-
-
-
-
-
-
Female, Group IV - 1 mg/kg/day - Day 94
655013
YES
_
_
-
-
-
-
-
-
655033
YES
-
-. -
-
-
-
-
-
655040 655041
YES YES
-
-
--
-
-
_ -
-
-
655044
YES
-
-
-
-
-
-
_
-
655086
NO
-
-
-
- YES/ADEQ
-
-
655089
YES .
-------
655090
YES
-
- --
-
-
-
-
-
655091
YES
-
-
-
-
-
-
-
-
655108
YES
-
-
-----
Female, 1Sroup VI - 5 mg/kg/day - Day 94
655020
YES
_ _
-
-
_
_
-
-
655029
YES
-
-
-
-
-
--
655034
NO
-
-
-
-
- YES/DECR
-
-
655038
NO
-
-
-
-
- YES/DECR -
-
655039
YES
-
-
-
-
-
-
- -
655042
YES
-
-
-
-
-
---
655054
YES
-
-
-
-
-
-
-
-
655066
NO
-
-
-
-
- YES/ADEQ
-
-
655067
YES
-
- -
----
655087
YES
-
-
-
-
-
-
-
-
-589-
)
DuPont-9478
9_0_-_D__ay__O__ra_l _G_a_v_a_g_e__S_tu_dSyubinchRraotnsi_c_T__o_x_ic_i_t_y
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Female, Group VIII - 25 mg/kg/dy - Day 94
655011
YES
-
-
-
-
-
-
-
-
655012
YES
-
-
-
-
-
-
-
-
65.5047
YES
-
-
-
-
-
-
-
-
655055
NO
-
-
- - YES/ADEQ - -
655058
YES
-
-
-
-
-
-
-
-
655073
NO
-
-
-
-
- YES/DECK -
-
655076
YES
-
-
-
-
-
-
-
-
65507.8
YES
-
-
-
-
-
-
-
-
655085
YES
-,
-----~
655105
NO
-
~
-
-
- YES/ADEQ -
-
Female, Group X - 125 mg/kg/day - Day 94
655007
YES
655023
YES
-
-
-
-
-
-
655026
NO/
- - - - YES/ADEQ
655052
YES
-
-
-
-
--
655053
YES
______
655063
YES
_
_
_
_
_
_
655092 YES
-
-
-
655095
YES
_
_
_
_
_
_
655097
YES
-
655103
YES
_
_
_
_
_
_
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-590-
flL90-Day
Oral
Gavage
Subchronic Study in Rats
Toxicity
Individual White Blood Cell / Platelet Morphology Values
Animal
NORM
SM
TOX
DB
VC
BC PCE GP
BP
Number
Female, Group II - 0 mg/kg/day - Day 183
655009 655015 655019 655035 655062 655068 655072 655101 655109
YES NO NO YES YES YES YES YES YES
_ -
-
-
-_
----
-
--~ --
-
_-
- YES/UTD - YES/OTD
--
--
-
--
--
--
_
-
-
_
_
-
-
Female, <Sroup X - 125 mg/kg/day - Day 183
655010 655030 655037 655049 655061
655075 655077 655084 655088 655100
YES YES YES YES YES YES
NO YES YES NO
_ -
-
_-
---
-
- - -- - - - ---
-- - - - -
-- - - - -
_--
---
- YES/ADEQ -
-
--
-
--
-
-
-- - - - -
- - - YES/ADEQ - -
)
DuPont-9478
Company Sanitized. Does not contain TSCA CBI
-591-
Company Sanitized. Does not contain TSCA CBI
90-jDayI^OHraIl^GWavHagKe JSStuudbycinh rRoantsic Toxicity
)
Animal Number
PHEM
PLIP
PICT
Male, Group I - 0 mg/kg/day - Day 93
654903 654925 654928 654929 654936 654950 654953 654972 654987
.654993
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group III - 1 mg/kg/day - Day
654908 654913 654932 654938 654941
654946 654947 654960 654984 654995 *,
NONE NONE NONE NONE TRACE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE' NONE NONE
Male, Group V - 5 mg/kg/day - Day 93
654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
16.2 15.5 15.4 16.8 16.7 16.6 15.8 15.9 NT 14.4
15.5 16.2 15.7 15.9 15.6 17.2 16.0 17.1 15.5 15.9
15.1 16.3 18.6 15.2 15.7 15.9 15.6 15.5 15.1 QNS
Individual Coagulation Values
APTT sec
18.2 19.9 22.3 15.2 19.7 16.9 19.7 17.0
NT 14.7
19.3 24.2 23.5 19.8 17.7 20.8 18.0 19.8 19.3 19.9
18.0 19.0
20.8
16.1 19.1 18.4 19.4 19.3 21.8 QNS
592
)
DuPont-9478
90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity
Animal Number
PHEM
PDIP
PICT
Male, Group VII - 25 mg/kg/day - Day
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group IX - 125 mg/kg/day - Day
654914 654921
654951 654955 654965 654979
654983 654986 654996 655003
NONE NONE NONE TRACE NSR NONE NONE NONE NONE NONE
NONE NONE
NONE NONE
NT NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NT NONE NONE NONE NONE NONE
PT sec
15.4 15.5 15.9 15.1 16.0 15.0 15.0 15.7 15.1 16.7
20.2 15.1 16.2 15.7
NT 15.3 15.4 14.3 14.7 15.8
Individual Coagulation Values
APTT sec
15.0 19.1 20.2 17.4 18.5 16.2 16.3 19.7 16.9 17.8
22.4 16.9
22.0
19.8 NT 19.9 20.2 17.1 18.2 17.4
Company Sanitized. Does not contain TSCA CBI
593
Animal Number
PHEM
PLIP
PICT
Female, Group II - 0'mg/kg/day - Day
655016 655025 655031 655032 655036 655079
655083 655098 655099 655107
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group IV - 1 mg/kg/day - Day
655013 655033 655040 65.5041 655044
655086 655089 655090 655091 655108
NONE NONE NONE NONE NONE NONE
TRACE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group VI - 5 mg/kg/day. - Day
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
PT sec
14.7 14.9 15.3 16.0 14.6 15.0 15.5 16.0 15.7 15.1
15.5 16.3 14.3 15.3 14.5 15.0 14.9 14.6 14.7 14.2
15.1 15.9 14.8 15.9 15.5 14.6 15.0 14.8 14.8 16.4
Individual Coagulation Values
APTT sec
19.3 12.9 17.7 15.0 16.8 15.4 15.7 15.6 14.5 14.9
18.1 19.1 15.2 16.1 13.2 14.7 19.2 .15.0 16.6 15.0
18.6 12.8 14.2 13.8 13.8 16.4 16.0 14.7 15.0 15.0
Company Sanitized. Does not contain TSCA CBI
594
Company Sanitized. Does not contain TSCA CB
Animal Number
PHEM
PLIP
PICT
PT sec
Female, Group VIII - 25 mg/kg/day - Day 94
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
14.6 15.5 15.9 15.9 15.7 15.1 15.5 14.1 14.9 14.7
Female, Group X - 125 mg/kg/day -- Day 94
655007 655023 655026 655052
655053 655063 655092 655095 655097 655103
NONE NONE NONE NONE
NONE NONE NONE NONE
NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
13.1 15.5 16.3 14.9 14.4
14.6 15.9 15.5 13.8 15.0
APTT sec
15.0 18.9 15.1 14.1 13.0 14.9 13.7 17.0 16.5 15.3
10.6
13.9 13.7 11.9 14.3 14.5 17.9 16.2 13.3 15.0
90-Day Oral Gavage_S_tuubdcyhirnonRiactsToxicity
Animal Number
SHEM
SLIP
SICT
Male, Group I - 0 mg/kg/day - Day 48
Individual
AST ALT U/L 0/L
654928 654903 654925 654929 654936 654950 654953 654972 654987 654993
TRACE
NONE TRACE TRACE NONE TRACE TRACE NONE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group III - 1 mg/kg/day - Day 48
83
61
65
68
57
86
70 56
77
66
39 36 32 33 28 36 32 28 31 30
654908 654913 654932 654938 654941 654946 654947 654960 654984 654995
NONE TRACE NONE TRACE NONE
NONE TRACE NONE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
62
70 71 71
73
66
79 69 61 71
30 35 26 34 40 28 44 31 32 34
Male, Group V - 5 mg/kg/day - Day 48
654907
TRACE
NONE
NONE
59
23
654911
TRACE
NONE
NONE
77
29
654916 TRACE
NONE
NONE
78
33
654917
NONE
NONE
NONE
77
36
654959
NONE
NONE
NONE
67
34
654961
NONE
NONE
NONE
63
28
654967
NONE
NONE
NONE
68
33
654980
TRACE
NONE
NONE
71
38 .
654998
NONE
NONE
NONE
71
27
655005 TRACE
NONE
NONE
71
39
OCD
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
SDH ALKP BILI
U/L
.U/L
mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
21.6 131 0.13 15 0,27 84
11.9
114 < 0.10
14
0..22
66
9.3 96 0.13 19 0.39 74
14.3 145 0 .1 1 1 1 . 1 137 0.12
12
16
0.,18 0 ,.26
61
68
17.4 143 0.13 15 0.28 63
14.5 QNS 0.14
14.5 120 0.10
12
16
0.24 0 ., 21
66
52
13.8
151 <0.10
11
0..21
66
12.3 138 0.15 14 0.28 56
15.6
13.9
10.5
11.0
17.5 14.9
14.2 7.8
12.2
14.1
97 <0.10 127 <0.10 112 <0.10 112 0.10
75 0.10 111 <0.10
127 0.10 157 <0.10 106 <0.10 119 0 .11
14
15
14
13
12 12
14
15 14 15
0.23
0.29 0.32 0.27
0.22
0.24 0.29 0.29
0.33 0.26
55
33 55 60
45 50 57 43 70 61
11.0
11.5 13.7 16.5 14.9
8.2
14.2 13.5 10.9 11.3
142 0.10
124 0.13
137 < 0.10
147 0.15
112 0.11 QNS 0.11
108 0.10 106 0.10 113 < 0.10
146 <0.10
11
13 ' 16 15
12 10
14
15
15
17
0.25 0.25 0.31 0.31
0 .2 2 ,
0.23 0.32 0.29
0.26 0.34
77 49 37 71 62 61 56 74 60 70
-596-
DuPont-9478
Animal Number
SHEM
SLIP
SICT
Male, Group VII - 25 mg/kg/day - Day 48
654922 654923 654930 654940 654952 654958 654975 654989 655001
655006
TRACE TRACE NONE TRACE NONE TRACE TRACE TRACE TRACE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Male, Group IX - 125 mg/kg/day - Day 48
654914 654921 654951 654955 654965 654979 654983 654986 654996 655003
NONE SMALL NONE TRACE TRACE NONE TRACE NONE NONE TRACE
NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
AST U/L
69 69 62 84
88
61 79 72 70 65
67 61 82 65 70 69 70 72 62 75
Individual Clinical Chemistry Values
ALT
SDH
ALKP
BILI
U/L
U/L
;U/L
mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
32 36 28 34 34 27
36 33 44 27
10.4
11.5
10.2
16.9
14.3 11.4
12.6
13.5 11.7
19.7
169 0.13
112 0.18
H I 0.12
208 0.13
101 <0.10 124 0 .1 1
115 0.10 118 0 .11
138 <0.10 155 <0.10
16 15 14 14 15 14 13 15 15 13
0.29
0.22
0.25 0.27
0.27 0.25
0.30 0.24 0.27
0.25
42 76 80 43 41 58 47 39 43 47
28 31 48 31
2'8
37 45 32
34 30
1 2 .7 243 <0.10
1 1 ..1 130 0 .11
2 2 .. 1
191 <0.10
1 0 ..1
192 <0.10
13..3 135 <0.10
1 0 ,.0
165 <0.10
13..0 149 0 .1 1
1 1 .7 167 <0.10
13,.8 101 0.10
15..1 172 0.12
13
12
13
14
13
11
13
13
12
16
0.26 0.23
0.26
0.21
0.26 0.25 0.24 0.29
0.22
0.34
51 52 44 51 57 52 78 72 51 61
Company Sanitized. Does not contain TSCA
O DO
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
Male, Group I - 0 mg/kg/day - Day 48
ALB g/dL
Individual
GLOB g/dL
CALC mg/dL
Chemistry Values
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
o
CO
Company Sanitized. Does not contain TSCA
654928 654903 654925 654929 654936 654950 654953 654972 654987 654993
78 115
77 118
58 122
83 116
1 1 1 117 100 112
132 134
103 123
78 . 123
54 112
6.4 6.7
6.7 6.4 7.1
6.7 6.5 6.4
6.1
6.3
Male, Group III - 1 mg/kg/day - Day 48
4.2 4.2 4.1 4.2 4.4 3.9 4.0 4.2 4.0 4.3
2.2
11.5
9.0
147.5
6.08
97.9
2.5
2.6 2.2
2.7
2.8
10.3
10.5
10.8 11.1 10.6
8.2
149.1
5.23
101.4
148.5
5.91
101.8
7.8 149.2 6.12 101.3
9.2
149.3
5.47
102.3
8.3
147.4
6.03
102.1
2.5
2.2 2.1 2.0
11.1
10.3
10.4
11.0
00
8.7
146.7
6.36
102.7
146.6
6.81
106.3
7.1
150.7
5.10
104.1
8.2
147.3
5.55
101.6
654908
27
126 6.7
654913
60
113 6.5
654932
51
127 7.4
654938
120
114
6.6
654941
80
107 6.5
654946
75
113
5.9
654947
92
105 6.8
654960
55
105
6.3
654984
102
125
6.9
654995
75
110
6.2
Male, Group V - 5 mg/kg/day - Day 48
4.2 2.5 4.2 2.3
4.6 2.8
4.1 2.5 4.0 2.5
3.7 2.2
4.4 . 2.4
4.0 2.3
4.3 2.6
3.9 2.3
10.5
10.9
10.8 11.1 10.6
10.5
11.2 10.6
10.9
10.6
7.5
148.0
6.04
103.8
8.6 147.2 5.96 98.1
7.7
162.6
5.98
112.4
7.8
148.3
6.04
102.2
7.8
148.2
5.07
104.8
7.2
149.7
5.10
103.2
8.5 146.2 6.42 100.8
8.2
147.6
5.22
101.8
7.1
148.2
5.33
101.5
8.5
149.3
5.61
102.9
654907 654911 654916 654917 654959 654961 654967 654980 654998 655005
91 48 18
88
142 125 57
106 80 193
108
128
145 126
116
115
120 121
124
119
6.0
6.4 6.7
6.9 7.4
6.6
6.4 7.2 6.4 6.3
4.1 1.9 3.9 2.5
4.1 2.6
4.4 2.5
4.6 2.8
4.2 2.4
4.2 2.2 4.4 2.8
4.0 2.4
3.9 ' 2.4
10.3
10.1 10.6 11.1
11.4
11.0
10.3
11.4
10.7
10.9
7.8
147.0
5.75
100.9
8.3 144.0 5.94 101.6
9.6
147.0
7.27
104.5
7.5
149.5
5.48
101.7
8.2
147.0
6.09
102.2
8.8
151.1
5.61
100.8
7.2
150.0
5.19
103.6
8.5
148.4
5.25
98.3
8.9
151.6
5.14
103.8
8.7
146.6
5.90
97.6
O CD
L
90-Day
Oral
Gavage
S__t_udSyubinchRroantsic
Toxicity
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Male, Group VIT - 25 mg/kg/day -.Day 48
654922
34
109 6.5 4.3
654923
85
109 6.3 4.2
654930
173
126
6.9
4.3
654940
56
113
6.1 4.2
654952
51
117 6.7 4.1
654958
43
133 6.4 4.1
654975
77
112
6.9 4.4
654989
89
127 6.5 4.3
655001
129
110
6.1
3.8
655006
93
119
6.6 4.2
Male, Group IX - 125 mg/kg/day - Day 48
654914 654921 654951 654955 654965 654979 654983
654996 655003
32 38 89 42 27 23 71 47
26 38
123 7.1
138 6.9
112 7.6
111 6.2
115 6.8
94 6.5
119 7.0
122 7.0
118'
7.3
170 7.2
4.8 4.6 4.8 4.4 4.4 4.5
4.6
5.0 5.0
4.9
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.2 2.1 2.6
1.9
2.6
10.6
10.4
10.7
10.2 10.2
8.6
10.7 7.7 ' 8.3 7.5
147.2 146.6 148.8 147.8 150.1
5.62 5.86 5.53 6.32 4.80
99.7 99.7
102.6
104.2
101.3
2.3 2.5
2.2
2.3
2.4
10.3
11.3
10.3
11.2 10.1
8.0
148.5
5.54
103.5
8.7
148.6
5.38
99.4
7.7
148.3
5.55 . 100.0
9.0
147.2
5.66
97.7
7.7
150.3
4.91
102.3
2.3
10.2
8.3
151.3
5.56
102.0
2.3
2.8 1.8
2.4
2.0
2.4
2.0
11.0 11.2
10.3
10.7
10.6 11.2 10.8
10.4 9.8 9.4 9.0 8.5 8.4 9.1
146.3 148.4 147.1 146.5 148.6 146.5 146.0
6.37 5.64 5.49 5.59 5.50 5.92 5.36
102.8 102.1
100.7 97.9
100.9 98.6 .104.1
2.3
11.0
8.2
147.7
5.70
99.3
2.3
11.3
10.8
148.4
6.24
102.2
CtCDOo to
B *
Company Sanitized. Does not contain TSCA CBI
C9.0-Day Oral Gavage StudSyuibnchRraotnsic Toxicity
Animal Number
SHEM
SLIP
SICT
Male, Group I - 0 mg/kg/day - Day 93
Individual
AST ALT TJ/L U/L
654903 654925 654928 654929 654936 654950 654953 654972 654987 654993
NONE TRACE SMALL
TRACE NONE TRACE SMALL SMALL
NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
69 74 108 94 84 93 73 80 86 84
31 28 40 38 37 34 39 32 46 38
Male, Group III - 1 mg/kg/day - Day 93
654908 654913 654932 654938 ,654941
654946 654947 654960 654984 654995
SMALL SMALL NONE TRACE NONE MODERATE
TRACE TRACE TRACE TRACE
NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
93 96 65 109 78
NT-HEMOL 95 79 83 90
39 57 32 49 45 NT-HEMOL 41 35 34 42
Male, Group V - 5 mg/kg/day - Day 93
654907 654911
654916 654917 654959 654961 654967 654980 654998 655005
TRACE NONE SMALL SMALL TRACE TRACE NONE TRACE NONE SMALL
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
.
163 88
91 293 111 66 73 79 75 100
35 33 37 173 47 32 31 32 29 45
OCD
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
SDH
ALKP
BILI
U/L U/L
mg/dL
BON mg/dL
CREA mg/dL
CHOL mg/dL
18.3 16.5 13.1
22.8
18.8 17.6 16.7 18.4 23.2 21.7
111 <0.10 76 0.10
128 0.15
135 0 .11
107 0.12 120 <0.10 74 0.10 101 0.11
150 0.12 85 0 .11
11
14
17
11
13
12 11
14
12
14
0.34 0.50
0.42 0.44
0..37
0.36 0.,46 0..52
0,.36 0..47
70 81
112
71 94 74
78 56 93 74
17.6 23.2 11.5 21.7 18.9 7.1
20.4 15.5 15.5 17.7
84
110
85 93
80
NT-HEMOL
111
130 79
105
<0.10 <0.10 0.10 <0.10 0.10
NT-HEMOL
<0.10 <0.10 <0.10 <0.10
14 14
13 17
12 12
18
13
14 15
0.36 0.43 0.28 0.47 0.29 0.44 0.39 0.44 0.52 0.29
63 40 61 65 49 49
54 56 73 57
10.4 123 0 .1 1 12 0.37 81
18.2 91 0 .11 13 0.30 61
13.1 63.0 12.3
104 <0.10
115 0.17
80 <0.10
14 14 14
0.37 0.37 0.33
36
100
59
13.4 81 0.13 10 0.32 81
11.5
14.3
12.1 6.6
76
68
81
91
0.11 0.11
0.10 0.10
12
15
12
15
0.37 0.41 0.35 0.44
67 96 78 83
600
DuPont-9478
90-Bay Oral liavag indSyuibnchRraotnsic Toxicity
)
Animal Number
SHEM
SLIP
SICT
AST U/L
Male, Group VII - 25 mg /kg/day - Day 93
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
SMALL NONE TRACE SMALL TRACE TRACE SMALL TRACE SMALL NONE
NONE ' NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
295 495 62 135 94 387 134 92 83 80
Male, Group IX - 125 mg/kg/day - Day 93
654914 654921
654951 654955 654965 654979 654983 654986 654996 655003
NONE SMALL TRACE SMALL TRACE SMALL TRACE TRACE NONE SMALL
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE '
83 64 93 72 87 119 75 78 64 70
Individual Clinical Chemistry Values
ALT
SDH
ALKP
BILI
U/L U/L :U/L mg/dL
BUN mg/dL
167 51.3 147 0.13
213 116.8 107
0.20
28 11 .8 88 <0.10
83
37.6
142 <0.10
33 14.4 72 <0.10
188 103.6 108
0.12
57 2 2 .1 91 <0.10
42 14.9 87 <0.10
43
18.9
125 <0.10
39 24.0 128 0 .11
14 17
12
15 16 16
15 16 16 13
46
19.5
194 <0.10
12
27 11.8 96 0 .11 11
60 22.6 176 0.10 14
42 13.7 171 0.10 16
34 18.0 101 0.10 14
78 33.7 142 0 .11 13
42 20.4 138 <0.10 13
28
17.1
136 <0.10
15
44 16.0 95 0.10 10
34 10.9 113 0.12 12
CREA mg/dL
0.39 0.42 0.30 0.36 0.35 0.39 0.47 0.29 0.32 0.36
0.39 0.35 0.37 0.37 0.40 0.37 0.36 0.45 0.28 0.37
CHOL mg/dL
57 104 78 60 42 80 63 54 58 61
58 63 51 91 55 56 77
86
50
66
)
DuPont-9478
Company Sanitized. Does not contain TSCA
O 03
__90-Day Oral Uavage Stu[dSyubinchRraotnsic Toxicity
Individual
Animal Number
TRIG mg/dli
GLUC mg/dL
TP g/dL
ALB g/dL
GLOB g/dL
Male, Group I - 0 mg/kg/day - Day 93
654903 654925 654928 654929 654936 654950 654953 654972 654987 654993
56 51 82 40 148 95 83 43 80 89
97 92
105 94
100 . 101
106 186
115
89
7.5 7.5 7.0 6.9 7.6 6.9 7.5 7.2 7.0 6.5
4.5 4.5 4.3 4.5 4.6 3.9 4.5 4.5 4.4 4.3
3.0 3.0 2.7
2.4
3.0
3.0 3.0 2.7
2.6 2.2
Male, Group III - 1 mg/kg/day - Day 93
654908
40
94 7.2 4.5 2.7
654913
49
95 6.6 4.2 2.4
654932
67
102
7.3 4.5 2.8
654938
89
165 7.3 4.4 2.9
654941
92
92 6.9 4.2 2.7
654946 NT-HEMOL 149 NT-HEMOL NT-HEMOL NT-HEMOL
654947
52
115
6.8 4.5 2.3
654960
36
96 6.8 4.2 2.6
654984
88
170
7.2 4.4 2.8
654995
92
91 6.6 4.0 2.6
Male, Group V - 5 mg/kg/day - Day 93
654907
74
96 6.6 4.2 2.4
654911
61
112
6.9 4.2 2.7
654916
18
178 6.7 4.1 2.6
654917
60
111
6.9 4.2 2.7
654959
102
122
7.0
4.3
2.7
654961
86
109
7.7 4.6
3.1
654967
67
103 6.8 4.4 2.4
654980
84
107 7.6 4.5 3.1
654998
95
98 7.6 4.5 3.1
655005
120
105
6.4
3.8
2.6
O 03
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
11.5
11.1 11.0 11.1 12.1 11.1 11.8 11.2
11.4
10.9
8.3
148.2
5.65
99.4
NONE
7.9
148.8
6.09
99.3
NONE
8.9
146.5
6.16
97.7
NONE
8.3
148.1
6.89
103.0
NONE
8.2
149.8
6.26
101.0
NONE
8.8
148.7
7.03
103.0
NONE
7.6
147.0
6.13
99.1
TRACE
8.4
149.6
5.40
103.0
NONE
7.5
150.6
5.71
100.1
TRACE
6.8
147.1
6.17
101.0
NONE
11.2
10.4
11.5
11.8 11.1
11.3
11.4
11.2 12.6 10.8
8.9
8.5
7.3
9.6
8.1
n t -h e m o l
9.4
8.0 12.1
7.9
146.5 148.4 151.4 147.9 152.0 147.2 148.6 148.1 153.1 150.8
7.24
5.85 5.94
6.20 .6.02
NT-HEMOL
6.20
5.51
6.28
6.23
102..8
98.4
101.6
102.4 103.9
101.5 99.4 103.3
101.4 103.6
NONE NONE NONE NONE TRACE TRACE NONE TRACE NONE NONE
10.1 11.6 11.1
11.3
11.0 11.8
11.4
11.3
12.1 10.2
7.5
9.6
10.0
9.0
9.6
8.2 8.6 8.2 8.2
7.6
147.1 148.8 145.4 145.9 146.3 152.8 152.3 147.6 151.6 144.9
6.22
7.09
6.45 7.04 6.41
6.12
6.18 6.45 5.71
5.38
102.9 100.4
101.4
101.4 101.7
101.1
103.7 99.5
100.2
98.8
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
-602-
DuPont-9478
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Male, Group VII - 25 mg/kg/day - Day 93
654922
35
88 7.1 4.7
654923
55
96 7.3 4.7
654930
91
117 7.2 4.4
654940
37
101 6.4 4.3
654952
62
106 6.8 4.1
654958
42
119 6.9 4.2
654975
48
188 7.2 4.5
654989
113 .
96
6.9 4.5
655001
87
94 6.5 4.0
655006
74
99 7.6 4.7
Male, Group IX - 125 mg/kg/day - Day 93
654914 654921 654951 654955 654965 654979 654983 654986 654996 655003
23 38 80 50 27 26 37 34 15 35
103 7.6 5.0 104 7.8 5.0
110 7.8 4.9
99 7.5 5.0
89 7.5 4.7 89 7.4 4.9
102 7.7 4.9
164 7.6 5.3
92 7.4 5.1
102 7.6 5.1
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.4
2.6 2.8 2.1
2.7
2.7
2.7
2.4 .
2.5
2.9
11.1 11.2 11.2 10.8 11.0 10.6
11.4
11.3
11.1
11.3
9.0
9.7
8.1
7.8
9.6
8.2
11.5 10.3 10.4
7.8
149 7 147 4 152 7
149 7
148 3 145 4
146 1
145 7
146 3 151 5
6.17 6.73 6.45 6.15 6.50 5.53 5.52 7.89 6.60 5.64
100.9 99.3 103.5
103.1
100.8
100.9 99.4
102.6
98.8
102.4
2.6 2.8 '
2.9
2.5
2.8
2.5
2.8
2.3
2.3
2.5
11.4
12.1 11.6 11.8
10.7
11.3
10.9
11.5
11.5
11.3
10.1 11.0
9.3
10.6
8.4
9.3
8.4
11.0
9.7
7.6
150 3
144 7
149 4
150 8 146 1 150 2 145 2 148 0 145 8
150 3
7.20 7.44
5.93 6.41
55.. 9895
6.15 5.83 6.51 5.75
101.3 99.9 100.3 99.2 97.9
100.3 99.1 101.9
98.3 102.4
PHEM
NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE
NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE
Company Sanitized. Does not contain TSCA CBI
603
Company Sanitized. Does not contain TSCA CBI
Animal Number
PLIP
PICT
PFLU MiJ/mL
Male, Group I - o' mg/kg/day - Day 93
654903 654925 654928 654929 654936 654950 654953 654972 654987 654993
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE
0.1
NONE
0.1
NONE
0.2
NONE
0.1
NONE
O.l'
NONE
0.1
NONE
0.1
NONE
0.1
NONE , 0.1
NONE
0.1
Male, Group III - 1 mg/kg/day - Day
654908 654913 654932 654938 654941 654946 654947 654960 654984
654995
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
0.1
Male, Group V - 5 mg/kg/day - Day 93
654907 654911 654916 654917
654959 654961 654967 654980 654998 655005
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1
0.1 0.1 0.1
0.1
0.1
Individual Clinical Chemistry Values
90-Day Oral Gavag_e_S_tu_dSyuibncRhraotnsic Toxicity
Animal Number
PLIP
PICT
PFLU /xg/mL
Male, Group VII - 25 mg /kg/day - Day
654922 654923 654930 654940 654952 654958 654975 654989 655001 655006
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1
0.1 0.1 0.1 0.2 0.1
Male, Group IX - 125 mg/kg/day - Day
654914 654921 654951 654955 654965 654979 654983 654986 654996
655003
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.3 0.4 0.4 0.4
0.4 0.4 0.4 0.4 0.3 0.4
Individual Clinical Chemistry Values
Company Sanitized. Does not contain TSCA CBI
-605-
Animal Number
SHEM
SLIP
SICT
AST U/L
Male, Group I - 0 mg/kg/day - Day 183
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
TRACE NONE TRACE TRACE NONE TRACE TRACE TRACE TRACE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
89 81 523 89
142 133 83 106 140 84
Male, Group IX - 125 mg/kg/day - Day 183
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
SMALL TRACE NONE TRACE SMALL TRACE TRACE TRACE TRACE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
146
235 72 132 91 157
88
143
188 92
Individual Clinical Chemistry Values
ALT
SDH
ALKP
BILI
BUN
U/L
U/L U/L
mg/dL
mg/dL
42 30
19.2 11.0
63 76
0 12 0 12
332 74.0 . 129 0 26
41 18.7 82 0 10
85 24.2 76 0 1 1
62 26.9 73 0 14
32 2 1.2 110 0 11
46 16.4 70 0 11
65 21.5 99 0 18
39 13.7 82 0 13
19 18 17 18 19 16 15 18 15
20
89 18..2 134 0.14 16
78 33..1 109 0.1 1 12
33
1 1 ..8
92
0.1 1
15
79 17..4 81 0.17 17
39 15..2 70 <0 .10 15
95 20..8 72 0.15 16
38 2 2 ..0 77 <0 .10 15
73 2 1 ..8 101 31..8
66
58
0.13 0.17
18 18
41
17,.6
97
0.13
14
CREA mg/dL
CHOL mg/dL
0.47 0.41 0.44 0.44 0.45 0.51 0.44 0.47 0.50 0.45
54 78 148 54
92
80 76 63
66
53
0.38 0.38 0.39 0.45 0.38 0.37 0.41 0.46 . 0.41 0.46
87 89 71 91 75 55
58 72
112
77
Company Sanitized. Does not contain TSCA CBI
-606-
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Male, Group I - 0 mg/kg/day - Day 183
654909
48
156
6.6
4.3
654910
130
144
6.9
4.2
654915
97
102 6.7 3.7
654924
66
196 6.9 4.2
654927
55
92
7.3 '
4.4
654943
100
188
7.3
4.3
654949
132
104
7.0
4.2
654956
83
104 6.6 4.0
654992
38
119 7.0 4.2
654994
60
82 6.9 4.3
Male, Group IX - 125 mg/kg/day - Day 183
654942
191
99
6.9 4.3
654957
48
152
6.8 4.1
654973
73
105 7.0 4.1
654974
104
163
6.9
4.2
654976
50
184 6.6 4.0
654977
50
122 6.7 4.1
654978
57
127 6.9 4.3
654985
45
128 6.9 4.3
654990
149
94
6.7 4.2
654991
186
91
7.0 4.3
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
mmol/L
mmol/L
2.3
11.2
8.8
147.0
6.47
102.7
2.7 3.0
11.5 11.9
9.4 9.6
146.9 149.9
6.78 6.28
105.0
102.0
2.7 2.9
11.7 11.7
9.0
8.8
146.9 148.1
6.05 6.87
101.5 103.5
3.0
2.8 2.6 2.8 2.6
12.1 10.6 11.2
11.3
10.8
8.7
148.7
5.61
102.5
7.3
147.0
5.60
98.8
7.9
150.1
6.06
105.7
8.3
146.1 6.29
101.5
7.4
148.5
5.71
99.3
2.6
11.3
9.0
148.3
6.48
105.5
2.7
2.9
2.7
2.6 2.6 2.6 2.6
11.5
11.5 11.7
11.4
11.6
11.5
11.6
10.3
10.3 8.7
11.0
8.4
8.8
9.0
147.3 151.0 145.7 148.1 150.0 145.3 149.6
5.95 7.32 5.68 5.89 6.09 6.57 6.56
105.2
106.6 102.9
104.5
106.5
101.8
100.9
2.5
10.6
8.4
146.7
6.72
103.7
2.7
11.9
7.8
152.0
5.59
103.5
PHEM.
NONE NONE NONE NONE NONE NONE NSR NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Company Sanitized. Does not contain TSCA
O CD
Animal Number
PLIP
PICT PgF/LmUL
ale, Group I - 0 mg/kg/day - Day 183
ooo ooo
654909 654910 654915 654924 654927 654943 654949 654956 654992 654994
NONE NONE NONE NONE NONE NONE
NT NONE NONE NONE
NONE
0.1
NONE
0.0
NONE
0.0
NONE
NONE
NONE
NT NT
NONE
0.0
NONE - 0.1
NONE
0.4
ale, Group IX - 125 mg/kg/day - Day 33
oO oo
654942 654957 654973 654974 654976 654977 654978 654985 654990 654991
NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1
0.1 0.1 0.1 0.1 0.1 0.1
Individual Clinical Chemistry Values
Company Sanitized. Does not contain TSCA
O03
90-Day Oral Gavag_e__S_tudSyubinchRraotnsic Toxicity
Animal Number
SHEM
SLIP
SICT
Female, Group II - 0 mg /kg/day - Day 49
AST U/L
Individual
ALT U/L
655016 655025 655031 655032 655036 655079 655083 655098 655099 655107
TRACE TRACE TRACE NONE TRACE NONE TRACE TRACE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
75 58 76 80 85 62 70 55 70 89
36 33 36 28 29
22 44 32 28 51
Female, Group IV - 1 rog/kg/day - Day 49
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
TRACE NONE NONE TRACE NONE TRACE TRACE TRACE TRACE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
83 83 80 72 61
110
52 69 80 75
28 36 49 34 28 43 31 27 34 38
Female, Group VI - 5 mg/kg/day - Day 49
6S5020
655029 655034
655038 655039 655042 655054 655066 655067 655087
TRACE NONE TRACE TRACE
NONE TRACE TRACE TRACE NONE TRACE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE
68
65
68
73
66
70
68
60
53
58
30 30
35 27 32 25 31 30
2290
O CD
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
SDH
ALKP
BILI
U/L ,U/L mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
13.9 109 0.13 7.3 89 0.16
11.4 83 0.12
15 17 17
0.34 0.34 0.38
98
64
101
13.2
12.6
62 62
0.12 0.10
14 17
0.25 0.41
54 69
10.5
8.6 6.0
79 79 70
0.13 0.13 0.18
16 15 14
0.36 0.32 0.29
99 50 90
9.0 105 0.21 12 0.30 82
12.7 95 0.19 15 0.34 64
6.9 105 0.13 16 0.32 98
10.4 82 0.13 16 0.36 60
11.4
59
0.15
17
0.34.
65
9.5 75 0.17 13 0.27 78
7.4 53 0 .1 1 15 0.33 90
20.9
8.6
7.7
85 65 87
0.16 0.15 0.16
19 16 14
0.45 0.32 0.38
91 104 73
9.7 109 0.21 12 .2 65 0.15
13 18
0.34 0.44
97 104
7.8 85 0.13 18 0.28 67
7.6 92 0.14 12 0.34 58
7.0 59 0.10 16 0.32 62
7.8 71 0.14 17 0.35 71
7.7 66 0.16 16 0.41 92
7.9 62 0 .1 1 15 0.40 70
9.5 139 0.12 19 0.41 87
7.3 78 0.14 15 ,0.25 90
9.5 68 0.16 15 0.35 81
7.1
65 <0.10 16
0.29
53
-609-
DuPont-9478
Company Sanitized. Does not contain TSCA CBi
Animal Number
SHEM
SLIP
SICT
; ^
Female, Group VIII - 25 mg/kg/day - Day 49
655011 655012 655047 655055
655058 655073 655076 655078 655085 655105
NONE TRACE TRACE NONE
SMALL NONE NONE TRACE TRACE NONE
NONE NONE NONE
NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
50 96
66
60
63 52
66
60 342 57
smale, Group X - 125 mg/kg/day - Day 49
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
TRACE TRACE TRACE TRACE TRACE NONE TRACE TRACE TRACE TRACE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE
56
74 53 53 73
68
54 50
68
56
Individual Clinical Chemistry Values
ALT
SDH
ALKP
BILI
U/L
U/L
;U/L
mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
26 7.9 62 48 14.0 50 34 8.9 92
27 6.2 62
26 9.3 78
30 7.0 42
26 7.7 72 35 8.7 62 158 139.0 142
33 9.7 66
0.18
0.13
0.13
0.12 0.12 0.10 0.10
0.13
0.23
0.13
14
17
18
17
12
18 15
11
15 17
0.29 0.36 0.35
0.28
0.40 0.32
0.25
0.21
0.39 0.42
123
102 102
91
75
101
84 84
172 114
33 33 27 33 30 27 26 34 41 37
8.0 54 0.19 12.7 104 0.12 8.8 70 0.16 8.1 79 0.18
10.4 67 0.14 9.4 91 0.13
8.2 62 0.15
9.4 80 0.13 14.6 69 0.19
10.4 71 0.16
13 0,30 120
18 0.31 94
20 0.39 96
16 0.31 92
15 0.30 102
14 0.32 77,
14 . 0.29
105
15 0.29 98
12
0.31
.146
13
0.32
135
DuPont-9478
Company Sanitized. Does not contain TSCA
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Female, Group II - 0 mg/kg/day - Day 49
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
655016 655025 655031 655032
655036 655079
655083 655098 655099 655107
64 116 38 114 34 104 29 106
42 129 27 126 25 113 89 123
56 117
31 100
7.3 7.3 7.3 6.9
7.2 7.6 7.0 7.0 7.7 7.6
Female, Group IV - 1 mg/kg/day - Day 49
4.8 5.1 4.8 4.5 4.9
5.1 4.7 4.8 5.0 5.3
2.5
2.2
2.5
2.4
2.3
11.4
11.4
11.2 11.0 11.6
7.9
145.4
7.05
100.2
9.1
143.4
5.15
100.1
6.9
144.9
6.44
98.5
7.1
147.3
5.76
103.9
9.0
145.6
6.16
103.0
2.5
2.3
2.2
2.7
2.3
11.3
11.0 1 0 .9
11.5
11.4
6.0
145.1
5.16
100.2
6.5
146.5
5.25
101.4
5.9 143.1 5.37 10 2 .1
6.0
146.9
4.87
102.0
5.7
143.8
6.20
100.7
655013 655033 655040 655041 655044
655086 655089 655090 655091 655108
35 29 36 95 56
49 74 4146 39
101
104 107
123
116
84
122 120
116
122'
7.5 7.0 7.0 7.0 7.5
7.5 7.5 7.1 7.5 7.6
Female, Group VI - 5 mg/kg/day - Day 49
4.9 4.5 4.8 5.0
4.9 5.0 5.0 4.7 5.1 5.0
2.6
2.5
2.2 2.0 2.6
2.5 2.5 2.4 2.4.
2.6
11.2 10.8
10.9
11.1
11.3
12.0
11.5 10.9 11.7
11.9
6.9
6.6 6.2
6.9
6.4
10.2
7.0
7.4
7.8
8.6
146.1
147.3 143.4 143.4 146.6 147.3 142.5 144.3 144.6 145.2
5.17 5.18 5.75 5.49
5.34 6.74 5.55 5.16 5.89 5.65
100.0
102.5
102.5 100.4
101.5
101.6 102.8
103.8
100.7 99.7
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
22
44 30 44 36 34 26 64 33 39 -
112
108
112
103 117 119
103
121
116
147
6.5 6.9
6.6
6.7
8.3 6.9
7.0 6.9
7.5 7.1
4.1 4.2 4.5 4.4 5.3 4.4 4.6 4.5 5.3 4.4
2.4
10.9
7.7
144.2
6.10
103.4
2.7
2.1
10.8 10.6
6.2.
6.3
145.2 144.4
5.61 5.18
103.0 100.3
2.3
10.9
7.4
142.2
5.31
99.8
3.0 2.,5
11.6 10.8
6.0
146.5
5.78
101.6
6.8
146.9
4.98
102.7
2.4
10.7
6.3
145.4
5.64
l'Ol.8
2.4
2.2
2.7
11.4
11.4
11.1
6.8
147.8
5.02
1 0 2 .3
6.3
144.0
5.50
102.1
8.1
144.1
5.91
101.9
O DO
DuPont-9478
C w90M-DafylHOrHal HGaHvaHgeKStuJdSyuibnchRraotnsic Toxicity
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Female, Group VIII - 25 mg/kg/day - Day 49
655011
50
121
7.7 5.1
655012
41
109 7.0 4.7
655047
33
110
7.5 5.0
655055
36
110 7.6 4.7
655058
32
115 6.7 4.6
655073
31
119 7.6 5.2
655076
30
107 7.2 4.7
655078
104
114
8.0
5.5
655085
40
118 8.1 5.0
655105
30
106 8.4 5.8
Female, Group X - 125 mg/kg/day - Day 49
655007
51
109 8.1
5.7
655023
62
121
7.2 5.1
655026
34
111
7.4 5.2
655052
39
103
7.8 5.5
655053
30
112
7.7 5.2
655063
26
117
8.0 5.6
655092
43
109 7.4 5.1
655095
40
108 8.5 5.8
655097
183
116
8.3
5.8
655103
39
107 8.3 5.8
Individual Clinical Chemistry Values
GLOB
9/dL
CALC mg/dL
IPHS rng/dL
NA . mmol/L
mmol/L
mmol/L
2.6
11.8
6.8
146.8
5.01
101.8
2.3
10.7
6.6
145.1
4.98
02.6
2.5
11.7
7.3
141.6
5.09
104.0
2.9
2.1
11.4 10.7
7.4
145.4
5.57
100.5
7.3
143.5
5.63
100.2
2.4 2.5 2.5
11.5
11.1
11.9
7.4
139.1
5.71
100.4
6.0
144.6
5,44
100.5
6.7
142.9
5.39
96.7
3.1
2.6
11.7 11.7
6.9
147.1
5.59
100.8
6.3 145.3 . 5.16 99.2
2.4
2.1 2.2
11.6
10.7 11.5
7.1
144.5
5.27
101.1
7.5
143.9
5.05
101.9
8.7
144.3
5.66
101.6
2.3 2.5
11.7
11.2
7.1
146.4
5.05
100.6
9.7
144.6
6.06
101.7
2.4
11.4
6.1
147.8
5.79
100.7
2.3
11.0
8.2
145.7
5.32
101.5
2.7
12.1
7.0
143.0
5.49
100.0
2.5
12.4
7.3
141.2
6.11
98.5
2.5
11.9
7.0
143.7
5.67
101.5
Company Sanitized. Does not contain TSCA
90-Day Oral Gavage _S_tudSyuibnchRraotnsic Toxicity
Animal Number
SHEM
SLIP
SICT
Individual
AST ALT U/L U/L
Female, Group II - 0 mg/kg/day - Day 94
655016 655025 655031
655032 655036 655079
655083 655098 655099 655107
NONE NONE TRACE
NONE TRACE NONE NONE NONE TRACE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
Female, Group IV - 1 mg/kg/day - Day 94
118
66
89
77
101 66
72
73
92 92
78 35 32 25 58' 23 41 29 32 46
655013 655033 655040 655041 655044
655086 655089 655090 655091 655108
' NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE
90
126
195
221
106
108
59 94
86 100
37
72 179
100
52
43 24 39
38 54
Female, Group VI - 5 mg/kg/day - Day 94
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
TRACE NONE
NONE TRACE TRACE NONE NONE TRACE NONE TRACE
NONE' NONE NONE. NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE
73 83
122
89
76 77
98 74
70 58
33 40 61 31
44 35 36 33 28 26
O CD
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
SDH
ALKP
BILI
U/L U/L mg/dL
BUN mg/dL
CREA mg/dL
CHOL mg/dL
22.9
62
0.16
19
0.51
106
13.4 41 0.14 17 0.45 89
21.3
56
0.14
20
0.50
108
16.3 47 0.14 13 0.43 60
21.5
11.0
37 45
0.13 0.14
18 18
0.51 0.50
95 99
11.5 12.7
43 42
0.14 0.17
15 18
0.32 0.48
59 94
17.3 64 0.14 16 0.55 77
18.8 70 0.17 18 0.45 66
15.2 77 0.12 19 0.47 90
20.5 55 0.18 17 0.47 70
40.1 35 0.13 19 0.47 99
28.3
43
0.21
13
0.46
112
25.6 36 0.12 17 0.51 86
22.9
55
0.15
16
0.54
102
16.9
48
0.17
18
0.48
113
13.6 58 0.12 19 0.47 84
18.3 66 0.17 18 0.48 95
13.4
43
0.15
17
0.56
116
14.2 63 0.10 20 0.40 65
15.6 55 0.15 18 0.45 83
15.8
10.2
44 49
0.13 0.14
18 17
0.50 0.47
73 73
13.9 47 0.12 17 0.51 96
13.1 32 0.12 18 0.32 72
18.1
102
0.13
17
0.45
81
9.3
58
0.13
15
0.46
114
14.3
11.1
39 0.13 16
49 <0.10 18
0.44 0.36
88
49
' -613-
DuPont-9478
90-Day Oral Gavage 'tudyuibncRhraotnsic Toxicity
Animal Number
SHEM
SLIP
SICT
AST U/L
Female, Group VIII - mg/kg/day - Day 94
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
54 73 95
140 76 70 71
110
984
83
Female, Group X - 125 mg/kg/day' - Day 94
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
TRACE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
150 65 61 97 92 79 96 55 174 64
Individual Clinical Chemistry Values ALT SDH ALKP BILI U/L U/L ,U/L mg/dL
BUN mg/dL
33 11.0 33 0.14 14
32 13.1 43 0.15 20
44 20.0 58 0.18 17
53 24.9 42 0.14 20
31 17.0 49 <0.10 15
36 17.0 33 0.14 16
31 17.3 57 0.14 15
77 29.4 39 0.13 12
374 283.2
99
0.20
17
35 11.5 41 0.14 26
75 35.4 44 0.19 12
32 17.3 72 0.18 17
31 10.7 54 0.22 18 50 22.0 66 0.21 18
39 18.3 52 0.13 17 35 12.9 55 0.13 15 30 7.3 49 0.18 17
38 12.7 47 0 .1 1 18
69 38.6 36 0.23 14
47 14.5 58 0.16 21
CREA mg/dL
0.42 0.50 0.37 0.42 0.45 0.53 0.40 0.46 0.57 0.71
0.46 0.43 0.50 0.43 0.46 0.43 0.39 0.44 0.43 0.60
CHOL mg/dL
170
121
107 93 80 108
100
98 228 140
144 95 125 89 105 105 84 106 195 184
DuPont-9478
Company Sanitized. Does not contain TSCA
O
90-Day Oral Gavage Stu_dSyuibnchRraotnsic Toxicity
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Female, Group II - 0 mg/kg/day - Day 94
655016
64
105 8.1 5.5
655025
42
92 8.4 5.9
655031
71
96 7.7 5.0
655032
34
90 7.6 4.8
655036
36
95 7.5 5.0
655079
24
105 7.7 5.1
655083
33
99' 7.4 5.1
655098
111
117
7.6
5.2
655099
44
114 8.3 5.2
655107
49
92 7.8 5.4
Female, Group IV - 1 mg/kg/day - Day 94
655013
35
93 7.7 5.1
655033
33
92 7.6 5.0
655040
50
108 8.2 5.7
655041
85
108 7.9 5.4
655044
47
115 8.0 5.2
655086
61
89 7.8 5.2
655089
212
124
8.2
5.6
655090
41 117
7.5
5.1
655091
44
100 8.1
5.7
655108
55
97 8.5 5.8
Female, Group VI - 5 m 3/kgVclay - Day 94
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
24 35 44 41 40 32 37 54 27 57
97 6.9 4.5 107 7.9 5.1
110 7.8 5.2
94 7.2 4.7
107 8.6 5.5
108 7.3 4.9
86 7.2 4.6
115 7.9 5.0 105 7.6 5.3
113 7.7 4.7
0O3
Company Sanitized. Does not contain TSCA
Clinical Chemistry Values
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
PHEM
11.6 11.7 11.5 11.7 11.4
11.5 11.5 11.2 12.8 11.6
6.0 6.3 6.2 7.3
6.9 6.3 7.2 4.6' 11.1 6.3
142.3 144.6 144.8 146.7 144.9 146.1
146.3 144.7 150.3 144.9
5.03 5.00 6.11 5.73 5.77 5.66 6.27 5.18 7.19 5.44
100.2 98.1 97.4 102.5 98.6 99.0 105.8 102.8 105.3 101.4
NONE TRACE NONE NONE NONE NONE TRACE NONE NONE No n e
11.1 11.6 11.7 11.2 11.5 11.5 11.8 11.4 11.7 11.6
6.2
145.4
5.44
98.1
NONE
7.0
145.0
5.39
101.7
NONE
5.2
146.4
5.11
101.3
NONE
4.6
144.1
5.26
101.1
NONE
5.8
147.2
5.87
102.8
NONE
5.5
146.8
5.51
100.3
NONE
6.6
144.0
6.30
100.4
TRACE
6.8
147.0
5.73
104.6
TRACE
6.5
146.7
5.77
100.9
NONE
5.0
143.9
5.02
99.3
NONE
11.0 11.5 11.9 11.2 11.9 11.2 10.8 11.7 10.8 11.4
7.2
145.7
6.39
102.3
TRACE
6.8
146.5
5.55
104.2
NONE
7.7
144.7
6.32
101.0
NONE
7.0
144.8
5.57
102.4
NONE
6.2
148.9
6.07
102.1
NONE
7.9
145.9
6.01
104.5
NONE
5.6
146.1
5.81
103.4
NONE
7.1
147.9
6.25
103.3
NONE
5.2
143.5
5.36
99.6
NONE
7.2
145.1
6.23
101.3
TRACE
-615-
DuPont-9478
90-Day Oral _a_v_a_g_e_S_tud'SyuibnchRraotnsic Toxicity
Animal Number
TRIG mg/dL
GLUC . mg/dL
TP g/dL
ALB g/dL
Female, Group VIII - 25 mg/kg/day - Day 94
655011 655012 655047
655055
655058 655073 655076 655078 655085 655105
33 43 54 28
29 27
35 64 56 43
104 8.7 5.9 104 7.7 5.3 98 7.8 5.1
91 7.9 5.2
95 7.3 4.9 147 8.0 5.6 97 7.8 5.0 116 9.0 6.3 108 9.3 5.6 101 9.0 6.2
Female, Group X - 125 mg/kg/day - Day 94
655007
30
99 8.5 5.8
655023
20
102 7.9 5.6
655026
23
101 9.1 6.2
655052
26
90 8.8 6.0
655053
37
102 8.7 5.7
655063
19
108 8.4 5.8
655092
29
103 7.7 5.3
655095
31
98 8.4 5.4
655097
175
94
8.9 6.0
655103
34
98 9.6 6.4
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
2.8
12.2
6.9
144.5
5.12
2.4
11.5
7.2
146.1
5.82
2.7
11.6
. 6.1
143.8
5.20
2.7
11.4
6.7
144.5
5.37
2.4
11.0
6.0
145.3
5.93
2.4
11.9
8.6
146.0
5.05
2.8
11.4
6.0
146.4
5.65
2.7
12.0
6.0
144.2
5.39
3.7
12.8
7.6
147.2
5.43
2.8
12.3
6.0
147.1
5.08
2.7
12.1
7.9
146.2
6.25
2.3
11.7
7.9
146.6
5.80
2.9
12.6
7.5
148.0
5.94
2.8
12.3
6.9
144.6
5.95
3.0
12.4
7.3
150.8
5.31
2.6
12.2
7.4
146.0
5.94
2.4
11.7
7.7
147.8
6.47
3.0
11.9
6.5
142.8
6.16
2.9
12.5
6.8
142.5
5.81
3.2
13.0
6.9
147.2
5.84
CL mmol/L
97.7 100.1 102.2 103.2 100.6 102.0 99.5 97.9 98.7 103.0
101.5 100.9 100.5 97.2 100.6 99.9 104.6 100.8 98.8 100.6
PHEM
TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE
NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE
Company Sanitized. Does not contain TSCA
O oo
Company Sanitized. Does not contain TSCA CBI
Animal Number
PLIP
PICT
PFLU Mg/mL
Female, Group II - 0 mg/kg/day - Day
655016 655025 655031 655032 655036 655079
655083 655098 655099 655107
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.2 0.2
Female, Group IV - 1 mg/kg/day - Day
655013 655033 655040 655041 655044 655086 655089 655090 655091 655108
NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.3 0.1 0.1 0.1 0.1
Female, Group VI - 5 mg/kg/day - Day
655020 655029 655034 655038 655039 655042 655054 655066 655067 655087
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE' NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.1 0.1 0.1
Individual Clinical Chemistry Values - 617-
Company Sanitized. Does not contain TSCA CBI
Animal Number
PLIP
PICT
PFLU M g /mL
Female, Group VIII - 25 mg/kg/day - Day 94
o to
655011 655012 655047 655055 655058 655073 655076 655078 655085 655105
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.2
0.2 0.2 0.2 0.1 0.1 0.2 0.2 0.2
smale, Group X - 125 mg/kg/day - Day 94
655007 655023 655026 655052 655053 655063 655092 655095 655097 655103
NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.5 0.6 0.6 0.6 0.4 0.5 0.3 0.3 0.5 0.3
Individual Clinical Chemistry Values
90-Day Oral Gav__age JStJudSyuibnchRraotnsic Toxicity
Animal Number
SHEM
SLIP
SICT
AST U/L
Female, Group II -- 0 mg/kg/day - Day 183
655009 655015 655019
655035 655062 655068 655072 655101 655109
TRACE NONE TRACE NONE NONE TRACE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
626 104 128 114 90 244 85 79 119
Female, Group X - 125 mg/kg/day - Day 183
655010 655030 655037 655049 655061 655075 655077 655084 655088 655100
NONE NONE TRACE TRACE TRACE TRACE NONE TRACE TRACE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE
253 76 102 68 91 68 79 105 91 95
Individual Clinical Chemistry Values
ALT
SDH ALKP
BILI
BUN
U/L U/L U/L mg/dL mg/dL
CREA mg/dL
323 98.0 47 0.34 13 0.52 77 17.7 30 0.12 18 0.45 58 24.3 43 0.19 18 0.60 61 24.0 40 0.16 17 0.49 62 14.6 26 0.15 15 0.49 136 42.2 29 0.15 21 0.54 36 11.0 28 0.14 18 0.57 45 11.8 37 0.12 17 0.54 65 19.2 24 0.13 19 0.50
167 44.9
43 19.9 64 20.1
25 8.4 49 12.6 30 11.9 32 12.4 46 11.0 64 18.7 56 14.9
29 <0 .10 18
0.48
32 0 14 11 0.42
37 0 15 15 . 0.55
43 0 .14 17 0.43
29 0 .17 21 0.57
37 0 .18 12 0.43
39 0 13 15 0.53
60 0 ,20 19 0.50
47 0 .16 13 0.39
30 0 .15 17 0.47
CHOL mg/dL
126 132 153 109 153 186 121 108 118
255 265 93 74 129 127 86 113 151 180
Company Sanitized. Does not contain TSCA C8I
-619-
90-Day Ora_l__G_a_v_a_g_e__S_tu_duybcinhrRoantisc Toxicity
Animal Number
TRIG mg/dL
GLUC mg/dL
TP g/dL
ALB g/dL
Female, Group XI - 0 mg/kg/day - Day 183
655009
64
97
8.0 5.2
655015
83
99 8.5 5.7
655019
78
196 8.6 5.7
655035
75
95 8.9 5.9
655062
79
124
9.0
6.2
655068
101
129
8.4
5.7
655072
54
108
8.4 5.7
655101
93
133 8.1 5.6
655109
75
105
8.2 5.5
Female, Group X - 125 mg/kg/day - Day 183
655010
100
99
8.6 5.0
655030
245
100
8.4
4.7
655037
52
107
7.9
5.3
655049
50
95 8.1 5.4
655061
50
111
9.0 6.2
655075
140
107
8.6
5.9
655077
41
110 7.9 5.3
655084
49 '
110
8.5
5.8
655088
81
102
8.1 5.4
655100
84
95 8.5 5.4
Individual Clinical Chemistry Values
GLOB g/dL
CALC mg/dL
IPHS mg/dL
NA mmol/L
K mmol/L
CL mmol/L
2.8 12.0 6.2
2.8 12.1 6.5
2.9
12.8
. 9.6
3.0 12.3 5.9
2.8 '12.9
5.8
2.7 12.5 8.3
2.7 12.5 7.9
2.5 12.3 7.2
2.7 12.5 6.5
148.3 149.6 149.6
148.9 149.8 146.0 150.7 146.8
148.5
6.00 4.94
6.16 5.37 5.11 5.92 6.30 6.56 5.81
103.2 104.7 103.5
100.9 104.4 102.9 105.3 105.7
105.9
3.6 3.7
12.2 12.6
8.0
147.1
5.67
101.2
7.3
148.7
5.78
100.4
2.6
11.8
6.1
149.2
5.57
103.8
2.7
11.9
6.7
150.9
5.48
106.4
2.8
12.7
7.5
151.6
5.32
106.2
2.7
12.6
9.3
149.8
6.93
102.3
2.6
11.9
6.5
150.8
6.69
107.2
2.7
12.2
8.5
151.2
5.70 . 104.6
2.7 3.1
12.3 12.2
7.9
147.9
6.22
102.5
6.5
149.0
6.01
104.1
PHEM
NONE NONE NONE NONE NONE NONE NONE NONE NONE
NONE. NONE NONE NONE NONE NONE NSR NONE NONE NONE
Company Sanitized. Does not contain TSCA
Animal Number
PLIP
PICT
PFLU Mg/mL
Female, Group II - 0 mg/kg/day - Day 183
655009 655015 655019 655035 655062 655068 655072 655101 655109
NONE NONE NONE NONE NONE NONE
NONE NONE NONE
NONE NONE NONE NONE NONE NONE NONE NONE NONE
0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.1
Female, Group X - 125 mg/kg/day - Day 183
655010 655030
655037 655049 655061 655075 655077 655084 655088 655100
NONE NONE NONE NONE NONE NONE
NT NONE NONE NONE
NONE NONE NONE NONE NONE NONE
NT NONE NONE NONE
0.1 0.1 0.0 0.1 0.1 0.1 NT 0.1 0.1 0.1
Individual Clinical Chemistry Values
Company Sanitized. Does not contain TSCA
O CD
