Document QJ3z691y6b32pEeGQjZ9eKGDL

7 3X7U- 456 Un7.G~3S.7lf DuPont-9478 TRADE SECRET Study Title 90-Day Oral Gavag[eSuSbtucdhyroinnicRTatosxicity Volume 3 of 3 Laboratory Project ID: DuPont-9478 Test Guidelines: UO.PSP.TESPA87H0.e3a1l0th0E(1ff9e9c8ts) Test Guidelines Au th o r: Gregory S. Ladies, Ph.D S tudy C o m pleted o n : April 1,2003 Perform ing L aboratory: ENEHl.eakIws.tkodaenurlklRP,LooDanaebdtlo,darPwea.tNaOorre.eymB1foo9oux7rr1H5s40ea-a0nl0dt5hC0aonmdpEannvyironmental Sciences W ork Request Number: Service Code Number: Page 622 of 967 Company Sanitized. Does not contain TSCA C8I 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity ) Individual urinalysis Values Animal QUAL COL CLAR VOL UOSM pH UGLU KET UBIL BLD URO Number mL mOsm/kg mg/dL mg/dL EU/dL Male, Group I - 0 mg/kg/day - Day 48 654928 654903 654925 654929 654936 654950 654953 654972 654987 654993 MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY CLOUDY HAZY CLOUDY HAZY HAZY CLOUDY HAZY CLOUDY 4.2 9.0 10.8 15.4 11.0 16.4 19.4 5.0 41.0 12.0 1781 856 840 492 822 533 593 1144 233 603 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE Moderate 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 Male, Group III - 1 mg/kg/day - Day 48 654908 654913 654932 654938 654941 654946 654947 654960 654984 654995 MEDIUM LIGHT MEDIUM MEDIUM LIGHT LIGHT LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLOUDY CLOUDY HAZY HAZY HAZY CLOUDY HAZY HAZY HAZY 7.0 22.0 5.4 10.8 17.2 6.2 12.0 5.6 14.6 - 8.4 1203 358 1431 949 461 925 660 1056 536 828 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 Male, Group V - 5 mg/kg/day - Day 48 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005 LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY CLOUDY HAZY CLEAR HAZY CLOUDY CLEAR CLOUDY CLEAR 14.0 9.2 5.2 6.9 12.6 9.8 27.0 10.0 10.6 11.2 619 1027 1409 1300 782 860 351 1036 1004 742 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 623- ''9_0_-_D_a_y__O_ra_l_G__a_v_a_g_e_S_tupduybicnhRroatnsi_c_T__o_x_ic_i_ty Animal QUAL COL CLAR VOL Number mL Male, Group VII - 25 mg/kg/day - Day 48 654922 654923 654930 654940 654952 654958 654975 654989 655001 655006 MEDIUM LIGHT LIGHT MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW, YELLOW CLOUDY HAZY CLOUDY CLEAR HAZY HAZY HAZY HAZY CLOUDY HAZY 7.2 29,0 19.4 5.6 6.8 11.6 10.4 21.0 14.4 5.0 Male, Group IX - 125 mg/kg/day - Day 48 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 LIGHT MEDIUM LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLOUDY HAZY HAZY CLOUDY HAZY HAZY CLOUDY HAZY HAZY 13.8 13.0 10.4 11.0 22.2 27.0 15.6 23.0 20.5 15.0 Individual Urinalysis Values UOSM mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 928 378 589 1283 1301 627 839 477 610 1364 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 691 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 751 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 695 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 896 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 481 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 355 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 622 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 530 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 432 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 601 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 624- Company Sanitized. Does not contain TSCA CBI avage StudSyubinchRraotnsic Toxicity Animal Number UMTP mg/dL Male, Group I - 0 mg/kg/day - Day 48 654928 654903 654925 654929 654936 654950 654953 654972 654987 654993 118 55 27 20 54 77 24 76 10 28 Male, Group III - 1 mg/kg/day - Day 48 654908 654913 654932 654938 654941 654946 654947 654960 654984 654995 62 21 91 52 24 30 77 72 19 32 Male, Group V - 5 mg/kg/day - Day 48 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005 21 53 78 105 41 32 13 114 60 34 Individual Urinalysis Values -625- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -90-Day Oral Gavage Stu[dSyubinchRraotnsic Toxicity Animal UMTP Number mg/dL Male, Group VII - 25 mg/kg/day - Day 48 654922 654923 654930 654940 654952 654958 654975 654989 655001 655006 75 13 19 99 49 25 28 24 41 101 Male, Group IX - 125 mg/kg/day - Day 48 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 42 35 39 130 64 12 27 29 19 37 Individual Urinalysis Values -626- ) DuPont-9478 90-Day Oral Gavage Study in Rats Individual Urinalysis Values Animal QUAL COL CLAR VOL UOSM PH UGLU KET UBIL BLD URO Number mL mOsra/kg mg/dL mg/dL EU/dL Male, Group I - 0 mg/kg/day - Day 93 654928 654903 654925 654929 654936 654950 654953 654972 654987 654993 MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOWYELLOW HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR HAZY HAZY HAZY 5.5 5.0 9.6 5.8 7.6 8.2 8.0 4.0 10.8 3.0 1475 1424 676 1415 1177 879 1323 1648 908 2283 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 8.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE TRACE 0.2 Male, Group III - 1 mg/kg/day - Day 93 654908 654913 654932 654938 654941 654946 654947 654960 654984 654995 MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR HAZY CLOUDY CLEAR CLEAR CLEAR CLEAR HAZY CLEAR 5.0 8.0 4.8 6.8 5.4 8.6 5.0 3.6 6.8 8.8 1574 1033 1516 1645 1613 798 1125 1690 1258 989 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE MODERATE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 Male, Group V - 5 mg/kg/day - Day 93 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005 LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY HAZY HAZY CLEAR 7.6 16.8 8.2 4.2 10.4 7.4 7.2 9.0 3.0 1.8 1117 536 1248 1886 947 1069 590 1226 2013 2301 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE TRACE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE, 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -627- ~90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity Animal QUAL COL CLAR VOL Number mL Male, Group VII - 25 mg/kg/day - Day 93 654922 654923 654930 654940 654952 654958 654975 654989 655001 655006 MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW, YELLOW CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR HAZY HAZY HAZY 3.6 19.6 6.8 5.8 5.6 2.0 5.8 16.0 7.4 5.2 Male, Group IX - 125 mg/kg/day - Day 93 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 LIGHT YELLOW LIGHT YELLOW LIGHT YELLOW MEDIUM YELLOW LIGHT YELLOW LIGHT YELLOW LIGHT ' YELLOW LIGHT YELLOW LIGHT YELLOW LIGHT YELLOW HAZY HAZY HAZY CLEAR HAZY HAZY CLEAR CLEAR CLEAR HAZY 17.8 29.0 7.2 6.2 12.6 31.5 10.8 41.0 41.0 14.0 Individual Urinalysis Values UOSM mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 1813 484 1285 1501 1454 3643 1618 687 1242 1766 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 SMALL NEGATIVE 1.0 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 567 400 1487 1480 588 350 922 284 324 623 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE SMALL 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE LARGE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -628- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuIdSyubinchRraotnsi_c_T__o_x_ic_ity Animal Number UFLU M9 UMTP mg/dL Male, Group I - 0 mg/kg/day 654928 654903 654925 654929 654936 654950 654953 654972 654987 654993 4.4 7.5 8.7 11.3 20.5 9.6 12.5 8.6 14.3 9.2 74 103 22 74 95 328 71 146 27 . 139 Male, Group III - 1 mg/kg/da 654908 654913 654932 654938 654941 654946 654947 654960 654984 654995 12.7 13.6 14.1 16.2 14.9 11.8 9.5 11.0 13.0 13.0 100 63 129 116 112 29 171 148 77 36 Male, Group V - 5 mg/kg/day 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005 39.3 46.7 38.9 33.1 36.6 51.1 21.6 52.3 29.3 QNS 37 26 68 139 46 74 27 114 163 119 Individual Urinalysis Values -629- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 90_-_D_a_y_O__ra_l_G__a_v_a_ge StuIdSyuibnchRraotnsic Toxicity Animal Number UFLU g UMTP mg/dL Male, Group VII - 25 mg/kg/day - Day 93 654922 654923 654930 654940 654952 654958 654975 654989 655001 655006 282.4 236.0 131.5 135.5 126.1 QNS 242.3 195.1 231.7 240.8 158 16 69 112 67 184 75 34 60 , 115 Male, Group IX - 125 mg/kg/day 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1203.7 915.4 895.7 879.9 716.7 893.4 958.5 1158.1 1557.8 793.1 36 29 90 314 68 10 47 9 14 52 Individual Urinalysis Values - 630- ) DuPont-9478 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity ) Animal QUAL COL CLAR VOL Number mL Male, Group I - 0 mg/kg/day - Day 183 GO CO in 654909 654910 654915 654924 654927 654943 654949 654956 654992 654994 LIGHT MEDIUM MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW ' YELLOW HAZY HAZY HAZY HAZY CLOUDY CLEAR CLEAR CLEAR CLEAR HAZY 3.6 3.0 22.0 3.6 10.0 5.8 15.2 1.0 Male, Group IX - 125 mg/kg/day - Day 183 654942 654957 654973 654974 654976 654977 654978 654985 654990 654991 MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CO fO 4.8 15.6 9.0 13.2 8.6 6.8 6.0 2.8 6.4 Individual Urinalysis Values UOSM mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 913 2189 2545 457 2552 923 1095 1219 709 QNS 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 1.0 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 8.0 NEGATIVE 15 NEGATIVE NEGATIVE 1.0 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 1788 693 1387 1375 671 752 1012 1486 2594 1461 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 o to 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 1.0 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -631- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Animal Number UFLU MS UMTP mg/dL Male, Group I - 0 mg/kg/day - Day 654909 654910 654915 654924 654927 654943 654949 654956 654992 654994 6.8 10.3 7.5 15.9 11.7 9.5 6.4 8.4 13 QNS 52.0 196.0 600.0 21.0 110.0 113.0 143.0 139.0 52.0 180.0 ' Male, Group IX - 125 mg/kg/day - 654942 654957 654973 654974 654976 654977 654978 654985 654990 654991 30.5 26.2 20.5 36 33.3 26.4 19.2 27.4 28.1 28.1 107.0 22.0 115.0 71.0 21.0 23.0 31.0 100.0 140.0 320.0 ) Individual Urinalysis Values -632- DuPont-9478 "90-Day Oral Gavage__S_tuJdSyubinchRraotnsic Toxicity Individual Urinalysis Values Animal QUAL COL CLAR VOL UOSM PH UGLU KET UBIL BLD URO Number mL mOsm/kg mg/dL mg/dL EU/dL Female, Group II - 0 mg/kg/day - Day 49 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR 5.2 8.8 8.6 15.0 4.0 3.6 5.2 6.0 7.4 7.8 909 599 780 497 825 1385 1293 879 970 681 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE Moderate 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE Trace 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 Female, Group IV - 1 mg/kg/day - Day 49 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108 LIGHT LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLOUDY CLEAR CLOUDY CLEAR CLEAR CLEAR CLEAR HAZY CLEAR 14.2 18.8 4.2 4.6 2.0 3.8 2.0 4.2 11.8 9.6 420 432 1037 1005 1537 1182 1835 1336 620 449 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE Trace 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 Female, Group VI - 5 mg/kg/day - Day 49 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087 MEDIUM LIGHT MEDIUM MEDIUM LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLOUDY CLEAR 3.2 9.0 3.6 5.2 21.0 14.6 2.0 6.6 13.0 3.8 1828 828 1113 1128 276 NT 1706 968 450 1150 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -633- 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity ) Individual Urinalysis Values Animal QUAL COL CLAR VOL UOSM pH UGLU KET UBIL BLD URO Number IClL mOsm/kg mg/dL mg/dL EU/dL Female, Group VIII - 25 mg/kg/day - Day 49 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW, YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR 8.8 9.2 8.0 7.8 19.0 10.8 50.0 8.4 18.0 4.2 858 679 870 655 321 648 125 744 427 906 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE Trace 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 Female, Group X - 125 mg/kg/day - Day 49 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLOUDY CLEAR CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR 4.0 20.0 7.0 5.6 3.0 11.0 13.0 4.6 8.4 5.4 1156 296 849 1223 2185 324 469 1362 758 920 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 DuPont-9478 Company Sanitized. Does not contain TSCA CBi -634- Company Sanitized. Does not contain TSCA CBI )0-Day Oral G__a_v_ag_e__S_tuIdSyubinchRraotnsic Toxicity Animal UMTP SPEC Number mg/dL Female, Group II - 0 mg/kg/day - Day 49 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 26 16 FECAL CONTAMINATION OBSERVED 27 9 19 27 24 22 35 FECAL CONTAMINATION OBSERVED 15 Female, Group IV - 1 mg/kg/day - Day 49 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108 16 10 25 40 FECAL CONTAMINATION OBSERVED 52 33 69 74 15 8 Female, Group VI 5 mg/kg/day - Day 49 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087 57 57 21 21 5 12 FECAL CONTAMINATION OBSERVED 37 17 13 21 Individual Urinalysis Values -635- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study in Rats Animal UMTP Number mg/dL Female, Group VIII - 25 mg/kg/day - Day 49 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 18 11 18 13 6 13 2 18 11 18 Female, Group X - 125 mg/kg/day - Day 49 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 95 12 17 28 74 21 12 104 59 33 Individual Urinalysis Values -636- > DuPont-9478 90-Day Oral Gavage__S_tuIdSyubinchRraotnsic Toxicity Animal QUAL COL CLAR VOL Number mL Female, Group II - 0 mg/kg/day - Day 94 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW , CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR 1.8 3.6 4.8 6.4 2.0 3.0 5.8 3.2 17.0 2.6 Female, Group IV - 1 mg/kg/day - Day 94 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT NT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR NT CLEAR CLEAR CLEAR 3.0 3.4 1.8 1.0 2.8 2.6 QNS 2.6 7.2 1.0 Female, Group VI - 5 mg/kg/day - Day 94 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR HAZY 4.4 10.0 2.0 6.8 3.4 4.0 3.0 2.8 1.8 4.0 Individual Urinalysis Values UOSM mOsm/kg pH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 2486 864 1088 1075 2137 1078 1217 1344 393 1678 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 1176 1181 2122 QNS 1548 1044 NT 1800 755 2528 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 NT NT NT NT NT NT 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 1464 460 2243 768 940 1394 1136 1941 1374 1452 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSC A CBI -637- Gavage Study-uibncRhraotnsic Toxicity ) Animal QUAL COL CLAR VOL Number mL Female, iGroup VIII - 25 mg/kg/day - Day 94 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW HAZY YELLOW HAZY YELLOW HAZY YELLOW HAZY YELLOW CLEAR YELLOW CLOUDY YELLOW HAZY YELLOW CLEAR YELLOW CLEAR YELLOW , CLEAR 2.8 3.4 10.8 8.6 2.6 4.6 2.0 2.0 7.4 3.4 Female, Group X - 125 mg/kg/day - Day 94 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR HAZY HAZY CLEAR HAZY CLEAR HAZY CLEAR 14.2 9.0 4.4 8.8 4.6 1.6 13.0 2.4 11.0 8.0 Individual Urinalysis Values UOSM mOsm/kg PH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL 2013 1690 686 578 1272 1004 1639 1655 833 939 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE MODERATE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 345 625 1367 718 1244 2593 542 1848 557 674 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 638- Company Sanitized. Does not contain TSCA CBI 1 "90-Day Ural Uavage SuIdSyubinchRraotnsic Toxicity Animal Number UFLU MU UMTP SPEC mg/dL Female, Group II - 0 mg/kg/day - Day 94 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 QNS 4.1 5.3 8.7 QNS 3.7 7.6 4.4 9.7 4.4 85 30 FECAL CONTAMINATION 20 20 FECAL CONTAMINATION 59 24 27 24 8 29 Female, iGroup IV - 1 mg/kg/day - Day 94 655013 655033 655040 655041 655044 655086 655089 655090 655091 655108 4.9 6.3 QNS QNS 6.4 3.4 NT 5.8 7.6 QNS 30 19 44 45 36 22 NT 112 16 111 Female, Group VI - 5 mg/kg/day - Day 94 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087 12.4 15.7 QNS 16.7 9.0 17.3 10.3 14.1 QNS 17.5 27 12 54 12 16 32 25 31 56 34 Individual Urinalysis Values -639- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity Individual Urinalysis Values Animal Number UFLU UMTP SPEC mg/dL Female, i3roup VIII - 25 mg/kg/day - Day 94 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 144.9 61.6 71.0 70.6 83.8 78.6 QNS QNS 119.9 73.2 496 34 FECAL CONTAMINATION OBSERVED 15 FECAL CONTAMINATION OBSERVED 11 22 58 FECAL CONTAMINATION OBSERVED 51 115 50 24 Female, Group X - 125 mg/kg/day - Day 94 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 873.5 766.5 436.4 883.7 1096.9 QNS 514.7 346.3 888.0 517.0 128 21 33 40 46 840 11 756 310 111 -640- ) DuPont-9478 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity Animal QUAL COL CLAR VOL Number mL Female, Group II - 0 mg/kg/day - Day 183 655009 655015 655019 655035 655062 655068 655072 655101 655109 NT NT MEDIUM LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT NT NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW . NT NT CLEAR CLEAR CLEAR HAZY CLEAR CLEAR HAZY QNS QNS 1.0 3.6 3.6 4.0 1.4 4.0 40.0 Female, 1Group X - 125 mg/kg/day - Day 183 655010 655030 655037 655049 655061 655075 655077 655084 655088 655100 MEDIUM LIGHT LIGHT LIGHT MEDIUM MEDIUM LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR HAZY CLEAR CLEAR HAZY CLEAR HAZY 2.4 11.8 2.2 2.8 1.0 5.8 4.4 13.8 1.0 4.2 Individual Urinalysis Values UOSM mOsm/kg PH UGLU mg/dL KET mg/dL UBIL BLD URO EU/dL NT NT 3391 1540 1616 269 2072 1306 142 NT NT NT NT NT NT NT NT NT NT NT NT 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 1753 502 2187 1447 3195 1151 1053 261 1972 925 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.5 NEGATIVE NEGATIVE SMALL TRACE 1.0 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 0.2 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -641 Company Sanitized. Does not contain TSCA CBI 90-Day O_r_a_l _ti_a_v_a_ge_ISStuudbycinhiRoantsic Toxicity Animal Number UFLU ug UMTP mg/dL Female, Group II - 0 mg/kg/day - Day 183 655009 655015 655019 655035 655062 655068 655072 655101 655109 QNS QNS QNS 5.6 7.3 5.4 QNS 7 34 QNS QNS 780 31 220.0 85 47.0 37.0 2.0 Female, Group X - 125 mg/kg/day 655010 655030 655037 655049 655061 655075 655077 655084 655088 655100 13.7 18.8 QNS 11.4 QNS 18.7 16.4 18.3 QNS 12.3 3380 990.0 62 22.0 135.0 181.0 156.0 21.0 230 700.0 Individual Urinalysis Values 642 ) DuPont-9478 Company Sanitized. Does not contain TSCA _9_U__-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Animal Number EPIT UWBC URBC NCRY Individual Urine Microscopic Values MICR SPER Male, Group I - 0 mg/kg/day - Day 48 654903 1 0 0 1 3 2 654925 654928 1 1 0 0 0 0 3 1 23 2 2 654929 1 0 0 1 3 1 654936 1 0 0 2 3 1 654950 1 0 0 1 3 2 654953 1 0 0 2 3 1 654972 1 0 0 2 3 2 654987 1 0 0 1 3 3 654993 1 0 0 1 3 1 Male, Group III - 1 mg/kg/day - Day 48 654908 654913 1 1 0 0 0 0 1 0 2 3 21 654932 654938 1 1 0 0 0 0 2 1 3 2 12 654941 1 0 0 1 3 3 654946 1 0 0 1 3 3 654947 654960 1 1 0 0 0 0 1 2 2 3 21 654984 1 0 0 1 3 3 654995 1 0 0 1 3 2 Male, Group V - 5 mg/kg/day - Day 48 654907 1 0 0 1 3 1 654911 1 0 0 1 3 1 654916 1 0 0 2 2 3 654917 1 0 0 1 3 2 654959 1 0 0 1 2 1 654961 1 0 0 2 2 1 654967 1 0 0 1 3 1 654980 1 0 0 2 2 3 654998 1 0 0 2 3 3 655005 1 0 0 1 3 3 O CD 643 DuPont-9478 90-Day Oral G_a_v_a_g_e_S_tujdSyubinchRraotnsic Toxicity Animal Number EPIT UWBC URBC Male, Group VII - 25 mg/kg/day - Day 654922 1 0 0 654923 1 0 0 654930 1 0 0 654940 1 0 0 654952 1 0 0 654958 1 0 0 654975 I 0 0 654989 1 0 0 655001 1 0 0 655006 1 0 0 Male, Group IX - 125 mg/kg/day - Day 654914 1 0 0 654921 1 0 0 654951 1 0 0 654955 1 1 0 654965 1 0 0 654979 1 0 0 654983 1 0 0 654986 1 0 0 654996 1 0 0 655003 1 0 0 NCRY 2 1 11 1 1 1 1 2 1 2 1 11 2 1 1 1 1 1 Individual Urine Microscopic Values MICR SPER 31 31 23 3 1 21 22 22 32 33 33 33 33 32 22 33 23 30 33 23 22 Company Sanitized. Does not contain TSCA CBI -644- Company Sanitized. Does not contain TSCA CBI '90-Day Oral Gavage Stu|dSyubinchRraotnsi_c_T__o_x_ic_i_ty ) Animal Number EPIT UWBC URBC NCRY Male, Group I - 0 mg/kg/day - Day 93 654903 1 0 0 1 654925 1 0 0 1 654928 1 0 0 1 654929 0 0 0 1 654936 1 0 0 1 654950 1 0 0 1 654953 1 0 0 1 654972 0 0 0 1 654987 1 0 0 1 654993 QNS QNS QNS QNS Male,. Group III - 1 mg/kg/day - Day 93 654908 1 0 0 1 654913 1 0 0 1 654932 1 0 0 1 654938 0 0 0 1 654941 1 0 0 1 654946 0 0 0 1 654947 1 0 0 1 654960 0 0 0 1 654984 1 0 2 1 654995 0 0 0 1 Male, Group V - 5 mg/kg/day - Day 93 654907 1 0 0 1 654911 0 0 0 1 654916 0 0 0 1 654917 0 0 1 1 654959 0 0 0 1 654961 0 0 0 1 654967 1 0 0 2 654980 0 0 0 1 654998 QNS QNS QNS QNS 655005 QNS QNS QNS QNS Individual Urine Microscopic Values MICR SPER SPEC 1 1 BELOW RECOMMENDED VOLUME 1 1 1-MUCUS STRANDS 1 3 1-MUCUS STRANDS 1 2 1-MUCUS STRANDS 1 0 1-MUCUS STRANDS 1 0 1-MUCUS STRANDS 1 1 1-MUCUS STRANDS 1 2 1-MUCUS STRANDS; BELOW RECOMMENDED VOLUME 1 3 1-MUCUS STRANDS QNS QNS 12 13 1 3 BELOW RECOMMENDED VOLUME 21 13 12 11 1 3 BELOW RECOMMENDED VOLUME 1 2 1-MUCUS STRANDS 12 1 1 1-MUCUS STRANDS 12 13 12 1 1 1-MUCUS STRANDS 13 1 1 1-MUCUS STRANDS 1 3 1-MUCUS STRANDS QNS QNS QNS QNS -645- ) DuPont-9478 90-Day Oral Gav_ag_e__S_tuIdSyubinchRraotnsic Toxicity Animal Number EPIT UWBC URBC NCRY Male, Group VII - 25 mg/kg/day - Day 93 654922 i 0 0 1 654923 i 0 0 1 654930 0 0 0 1 654940 0 0 0 1 654952 1 0 0 1 654958 QNS QNS QNS QNS 654975 0 0 0 1 654989 1 0 0 1 655001 0 0 0 1 655006 0 0 0 1 Male, Group IX - 125 mg/kg/day - Day 93 654914 0 0 0 1 654921 0 0 0 0 654951 1 0 0 2 654955 1 0 0 1 654965 0 0 0 1 654979 0 0 0 1 654983 0 0 0 1 654986 0 0 0 1 654996 1 0 0 1 655003 1 0 2 1 Individual Urine Microscopic Values MICR SPER SPEC 1 2 BELOVJ RECOMMENDED VOLUME 12 13 1 2 1-MUCUS STRANDS 1 2 1-MUCUS STRANDS QNS QNS 12 21 13 1 3 BELOW RECOMMENDED VOLUME 33 23 13 11 13 23 11 11 22 1 1 1-MUCUS STRANDS ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -646- 3-Day Gavage StudyuibnchRraotnsic Toxicity Individual Urine Microscopic Values Animal EPIT UWBC URBC NCRY MICR SPER SPEC I Number Female, Group II - 0 mg/kg/day - Day 49 655016 1 0 0 1 2 0 655025 1 0 0 1 2 0 655031 1 0 1 1 3 0 655032 1 0 0 2 3 0 655036 0 0 0 0 3 0 655079 1 0 0 0 1 0 655083 1 0 0 1 1 0 655098 1 1 0 1 2 0 655099 1 1 0 1 3 0 655107 1 0 0 1 3 0 Female, Group IV - 1 mg/kg/day - Day 49 655013 0 0 0 1 3 0 655033 1 0 0 1 3 0 655040 1 1 0 0 3 0 655041 1 0 0 2 3 0 655044 1 1 0 0 2 0 BELOW RECOMMENDED VOLUME 655086 1 0 0 0 2 0 V 655089 1 0 0 0 3 0 BELOW RECOMMENDED VOLUME 655090 1 0 0 1 2 0 655091 1 0 0 1 3 0 655108 1 0 0 0 2 0 Female, Group VI - 5 mg/kg/day - Day 49 655020 1 1 0 0 3 0 BELOW RECOMMENDED VOLUME 655029 0 0 0 0 2 0 655034 1 0 0 0 1 0 BELOW RECOMMENDED VOLUME 655038 1 0 0 0 1 0 655039 1 0 0 0 3 0 655042 0 0 0 3 3 0 655054 1 0 0 0 1 0 BELOW RECOMMENDED VOLUME 655066 1 0 0 2 3 0 655067 1 0 0 1 3 0 655087 1 0 0 0 1 0 Company Sanitized. Does not contain TSCA CBI -647- ) DuPont-9478 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity ) Animal Number EPXT UWBC URBC NCRY Female, Group VIII - 25 mg/kg/day - Day 49 655011 i 0 0 2 655012 i 0 0 0 655047 i 0 0 0 655055 i 1 0 0 655058 0 0 0 0 655073 0 0 0 1 655076 1 0 0 0 655078 1 0 0 1 655085 1 0 0 2 655105 1 0 0 1 Female, iGroup X - 125 mg/kg/day - Day 49 655007 1 0 0 2 655023 1 0 0 1 655026 1 0 0 0 655052 1 0 0 0 655053 1 0 0 0 655063 1 0 0 0 655092 1 0 0 2 655095 1 0 0 0 655097 1 0 0 0 655103 1 0 0 1 Individual Urine Microscopic Values MICR SFER SPEC 30 20 20 30 20 30 30 20 20 20 30 3 0 EPITHELIAL CELLS APPEAR DEGENERATED 1 0 EPITHELIAL CELLS APPEAR DEGENERATED 3 0 1-MUCUS STRANDS 2 0 BELOW RECOMMENDED VOLUME 10 30 2 0 1-MUCUS STRANDS 30 20 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -648- Company Sanitized. Does not contain TSCA 90-Day Oral Gavage tudSyuibnchRraotnsic Toxicity Animal Number EPIT UWBC URBC NCRY Individual Urine Microscopic Values MICR SPER SPEC Female, Group II - 0 mg/kg/day - Day 94 655031 655016 0 QNS 0 QNS 0 QNS 1 QNS 1 QNS 0 1-MUCUS STANDS; BELOW RECOMMENDED VOLUME QNS 655025 QNS QNS QNS QNS QNS QNS 655032 1 0 0 1 1 0 655036 QNS QNS QNS QNS QNS QNS 655079 QNS QNS QNS QNS QNS QNS 655083 1 0 0 0 1 0 655098 QNS QNS QNS QNS QNS QNS 655099 0 0 0 0 1 0 655107 QNS QNS QNS QNS QNS QNS Female, Group IV mg/kg/day - Day 94 655013 QNS QNS QNS QNS QNS QNS 655033 655040 0 QNS 0 QNS 0 QNS 0 QNS 1 QNS 0 BELOW RECOMMENDED VOLUME QNS 655041 QNS QNS QNS QNS QNS QNS 655044 QNS QNS QNS QNS QNS QNS 655086 QNS QNS QNS QNS QNS QNS 655089 QNS QNS QNS QNS QNS QNS 655090 QNS QNS QNS QNS QNS QNS 655091 655108 1 QNS 0 QNS 0 QNS 0 QNS 1 QNS 0 BELOW RECOMMENDED VOLUME QNS Female, Group VI mg/kg/day - Day 94 655020 655029 655034 0 0 QNS 0 0 QNS 0 0 QNS 0 0 QNS 1 1 QNS 0 BELOW RECOMMENDED VOLUME 0 BELOW RECOMMENDED VOLUME QNS 655038 1 0 0 1 1 0 655039 QNS QNS QNS QNS QNS QNS 655042 655054 1 QNS 0 QNS 0 QNS 1 QNS 1 QNS 0 BELOW RECOMMENDED VOLUME QNS 655066 QNS QNS QNS QNS QNS QNS 655067 QNS QNS QNS QNS QNS QNS 655087 1 0 0 1 1 0 BELOW RECOMMENDED VOLUME O 00 DuPont-9478 -Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Animal Number EPIT UWBC URBC NCRY Female, Group Vili - 25 mg/kg/day - Day 94 655011 QNS QNS QNS QNS 655012 QNS QNS QNS QNS 655047 1 0 0 1 655055 1 0 0 1 655058 QNS QNS QNS QNS 655073 0 0 0 1 655076 QNS QNS QNS QNS 655078 QNS QNS QNS QNS 655085 0 0 0 0 655105 QNS QNS QNS QNS Female, Group X - 125 mg/kg/day - Day 94 655007 0 0 0 0 655023 0 0 0 1 655026 1 0 0 1 655052 0 0 1 1 655053 1 0 0 0 655063 QNS QNS QNS QNS 655092 0 0 0 1 655095 QNS QNS QNS QNS 655097 0 0 0 1 655103 0 0 0 1 Individual Urine Microscopic Values MICR SPER SPEC QNS QNS QNS QNS 10 10 QNS QNS 2 0 BELOW RECOMMENDED VOLUME QNS QNS QNS QNS 10 QNS QNS 10 10 1 0 BELOW RECOMMENDED VOLUME 10 1 0 BELOW RECOMMENDED VOLUME QNS QNS 10 QNS QNS 1 0 1-MUCUS STRANDS 10 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -650- ^90-Day Oral Gav_a_g_e_S__tu[dSyubinchRraotns_ic_T__o_x_ic_i_ty_ DuPont-9478 APPENDIX L INDIVIDUAL ANIMAL BIOCHEMICAL DATA -651- Company Sanitized. Does not contain TSCA CBI 90-Day Oral _v_a_g_e__StiuSduybcinhrRonaitcs Toxicity DuPont-9478 INDIVIDUAL ANAITMTAHLEB1IO0-CDHAEYMTIICMAELPDOAINTAT IN MALE RATS Group I HI V vn IX Animai Number 666665555555555111113321175495 666665555555555111113321429084 655121 655126 665555113217 655138 666665555555555111113221135962 655113 655122 665555112283 655130 Beta-Oxidation Rate (nmol/min/mg protein) 13.71 11114464....29471753 1111145531.....5353491723 18.35 17.77 13.89 15.53 14.12 11113446....33214277 15.19 26.88 221657...126536 24.61 -652- Company Sanitized. Does not contain TSCA CBI "^O-Day Ora_l _G_av_ag_e_StJudSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 INDIVIDUAL ANIM AL BIOCHEMICAL DATA IN MALE RATS AT THE 90-DAY TIME POINT Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRteaiten) I 666665555544444999999227538920 1111141321.....0302505222 m 666665555544444999999441315738 1111134125.....2694451579 V 666665555544445999906805010795 1111181313.....5096019222 v n 666665555554444099990742315020 1111140452.....1018654529 rx 666665555554444099990886733659 2221113277.....8554718764 -653- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibncRhraotns_ic_T__o_x_ic_i_ty_ DuPont-9478 INDIVIDUAATLTAHNEI3M-MALONBTIOHCRHEECMOIVCEARLYDTAITMAEIPNOMINATLE RATS Group NAunmimbaelr (nBmetoal-/mOxinid/matgiopnroRtaeitne) I 654994 666555444999029942 654943 181.0.856 111121...559930 IX 666665555544444999997987760584 1111173652.....0244337282 -654- Company Sanitized. Does not contain TSCA CBI 90-Day Ora] avage StudyuibnchRraotnsic Toxicity INDIVIDUAATLTAHNEIM10A-DLADYATTIAMIENPFOEIMNTALE RATS Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRteaitne) n 666665555555555111115544515992 2222124149.....3149386388 IV 666665555555555111116666454202 2222131329.....2547918639 VI 666665555555555111116545478540 2221149699.....0866111166 v m 666665555555555111116664413684 2222271213.....0845225327 X 666665555555555111115544410736 3332201482.....1743735596 DuPont-9478 -655 - Company Sanitized. Does not contain TSCA CBI ISubchronic Toxicity 3>0-Pay Oral Gavage Study in Rats_________ INDIVIDUAATLTAHNEIM90A-DLADYATTIAMIENPFOEIMNTALE RATS Group NAunmimbaelr (nBmetoal-/Omxinid/mataiopnroRtaetien) n 666665555555555001003901718769 2222259408.....6670175340 IV 666665555555555010004084418604 2222275544.....4906086000 VI 666665555555555000003523384949 2322257075.....3632639644 v m 666665555555555010005054785576 3322223588.....3462851040 X 666665555555555010006095233726 4443302335.....7572087890 DuPont-9478 -656- Company Sanitized. Does not contain TSCA CBI "90-D_a_y_O__r_a_l _G_a_v_a_g_e_S_t_u[dSyubinchRraotns_ic__T_o_x_icity INDIVIDUAL ANIMAL DATA IN FEMALE RATS AT THE 3-MONTH RECOVERY TIMEPOINT Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRteaitne) n 666655555555000063108559 655062 222153...670186 2243..7652 v in 665555008787 666555555000431900 2255..9318 331228...149782 DuPont-9478 -657- Company Sanitized. Does not contain TSCA CBI "90-Day Oral Gavage StuIdSyubinchRraotns_ic__T_o_x_ic_i_ty DuPont-9478 APPENDIX M INDIVIDUAL ANIMAL BODY AND ORGAN WEIGHTS -658- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : I 0 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW 1 BRAIN j ADRENAL GLANDS j EPIDIDYMIDES | (Gms) (Gms) %FBW (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN (Gms) HEART 1 KIDNEYS %FBW %BRAIN (Gms) %FBW %BRAIN 1 654903 1 654925 1 654928 1 654929 1 654936 1 654950 1 654953 1 654972 1 654987 1 654993 ! 1 Mean 1 S.D. 578.50 575.80 566.30 506.10 583.70 520.70 646.30 498.80 566.40 486.80 552.94 49.145 2.187 0.3780 2.190 0.3803 2.123 0.3749 2.184 0.4315 2.137 0.3661 2.139 0.4108 2.175 0.3365 2.341 0.4693 2.316 0.4089 2.066 0.4244 2.186 0.3981 0.084 0.0383 0.057 0.0099 2.6063 0.065 0.0113 2.9680 0.061 0.0108 2.8733 0.063 0.0124 2.8846 0.048 0.0082 2.2461 0.058 0.0111 2.7115 0.072 0.0111 3.3103 0.063 0.0126 2.6912 0.077 0.0136 3.3247 0.048 0.0099 2.3233 0.061 0.0111 2.7939 0.009 0.0016 0.3601 1.634 0.2825 74.714 1.735 0.3013 79.224 1.651 0.2915 77.767 1.783 0.3523 81.639 0.791 0.1355 37.015 1.609 0.3090 75.222 1.555 0.2406 71.494 1.655 0.3318 70.696 1.561 0.2756 67.401 1.308 0.2687 63.311 1.528 0.2789 69.848 0.289 0.0595 12.791 1.885 0.3258 86.191 1.652 0.2869 75.434 1.785 0.3152 84.079 1.847 0.3649 84.570 1.555 0.2664 72.766 1.901 0.3651 88.873 1.921 0.2972 88.322 1.678 0.3364 71.679 1.981 0.3498 85.535 1.405 0.2886 68.006 1.761 0.3196 80.545 0.184 0.0345 7.7301 4.177 0.7220 190.99 3.551 0.6167 162.15 3.885 0.6860 183.00 3.745 0.7400 171.47 3.497 0.5991 163.64 4.513 0.8667 210.99 4.361 0.6748 200.51 4.197 0.8414 179.28 4.268 0.7535 184.28 3.041 0.6247 147.19 3.924 0.7125 179.35 0.463 0.0912 19.034 Group : III 1 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW BRAIN (Gms) (Gms) %FBW 654908 654913 654932 654938 654941 654946 654947 654960 516.10 534.10 566.10 579.40 515.80 577.70 489.60 513.20 2.313 0.4482 2.149 0.4024 2.082 0.3678 2.213 0.3819 2.229 0.4321 2.175 0.3765 1.999 0.4083 2.030 0.3956 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.031 0.0060 1.3403 0.035 0.0066 1.6287 0.035 0.0062 1.6811 0.038 0.0066 1.7171 0.045 0.0087 2.0188 0.065 0.0113 2.9885 0.051 0.0104 2.5513 0.053 0.0103 2.6108 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.372 0.2658 59.317 1.605 0.3005 74.686 1.573 0.2779 75.552 1.536 0.2651 69.408 1.650 0.3199 74.024 1.775 0.3073 81.609 1.355 0.2768 67.784 1.458 0.2841 71.823 HEART 1 KIDNEYS (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 1.736 0.3364 75.054 1.820 0.3408 84.691 1.856 0.3279 89.145 2.031 0.3505 91.776 1.766 0.3424 79.228 1.856 0.3213 85.333 1.688 0.3448 84.442 1.889 0.3681 93.054 3.872 0.7502 167.40 3.455 0.6469 160.77 4.174 0.7373 200.48 3.756 0.6483 169.72 4.177 0.8098 187.39 3.673 0.6358 168.87 3.737 0.7633 186.94 3.658 0.7128 180.20 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -659- 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : III 1 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW BRAIN 1 1 (Gins) [(Gms) %FBW 1 654984 1601.80 2.184 0.3629 1 654995 j 1I 514.10 1 2.295 1 0.4464 1 I1 1 Mean [540.79 1 2.167 0.4022 1 S.D. 37.400 j 0.105 0.0313 ADRENAL GLANDS I EPIDIDYMIDES (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 0.066 0.0110 3.0220 1 1.498 0.2489 68.590 0.063 0.0123 2.7451 ! 1.669 0.3246 72.723 0.048 0.0089 2.2304 0.013 0.0024 0.6217 1.549 0.2871 71.552 0.133 0.0251 5.8859 HEART (Gms) %FBW %BRAIN 1.879 0.3122 86.035 1.800 0.3501 78.431 1.832 0.3394 84.719 0.095 0.0160 5.8132 KIDNEYS j (Gms) %FBW %BRAIN 3.475 0.5774 159.11 4.065 0.7907 177.12 3.804 0.7073 175.80 0.263 0.0764 13.117 Group : V 5 mg/kg/day Sex MALES 1 ANIMAL 1! FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES | HEART 1 KIDNEYS 1 ! (Gms) 1(Gms) %FBW | (Gms) %FBW %BRAIN \ (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN 654907 1532.90 654911 619.90 654916 526.30 654917 587.80 654959 621.10 654961 643.30 654967 513.30 654980 1626.50 654998 1587.60 655005 567.80 Mean S.D. ! 582.65 46.186 2.138 0.4012 2.419 0.3902 2.329 0.4425 2.187 0.3721 2.271 0.3656 2.228 0.3463 2.171 0.4229 2.248 0.3588 2.214 0.3768 2.134 0.3758 2.234 0.3852 0.089 0.0296 0.055 0.0103 2.5725 0.061 0.0098 2.5217 0.066 0.0125 2.8338 0.071 0.0121 3.2465 0.067 0.0108 2.9502 0.062 0.0096 2.7828 0.059 0.0115 2.7176 0.091 0.0145 4.0480 0.061 0.0104 2.7552 0.055 0.0097 2.5773 0.065 0.0111 2.9006 0.011 0.0016 0.4555 1.368 0.2567 63.985 1.706 0.2752 70.525 1.674 0.3181 71.876 1.846 0.3141 84.408 1.747 0.2813 76.926 1.570 0.2441 70.467 1.545 0.3010 71.165 1.530 0.2442 68.061 1.434 0.2440 64.770 1.814 0.3195 85.005 1.623 0.2798 72.719 0.160 0.0317 7.2988 1.555 0.2918 72.732 1.981 0.3196 81.893 1.703 0.3236 73.122 1.816 0.3089 83.036 1.763 0.2839 77.631 1.943 0.3020 87.208 1.549 0.3018 71.350 1.981 0.3162 88.123 2.055 0.3497 92.818 1.627 0.2865 76.242 1.797 0.3084 80.415 0.187 0.0199 7.3639 3.747 0.7031 175.26 4.815 0.7767 199.05 4.286 0.8144 184.03 4.109 0.6990 187.88 4.601 0.7408 202.60 4.430 0.6886 198.83 3.372 0.6569 155.32 3.928 0.6270 174.73 4.282 0.7287 193.41 3.304 0.5819 154.83 4.087 0.7017 182.59 0.501 0.0689 17.359 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -660- 90-Day Oral Gavage fcluSduybinchRroatnsic Toxicity > DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : VII 25 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES j (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN j (Gms) HEART 1 .KIDNEYS 1 %FBW %BRAIN | (Gms) %FBW %BRAIN j 654922 654923 654930 654940 654952 654958 654975 654989 655001 655006 1 1 Mean 1 S.D. 555.60 539.30 596.10 534.80 598.40 483.10 554.90 580.50 641.70 557.00 564.14 43.119 2.183 0.3929 | 2.242 0.4157 ! 2.234 0.3748 2.330 0.4357 2.126 0.3553 1.979 0.4096 2.120 0.3821 2.181 0.3757 2.139 0.3333 2.214 0.3975 2.175 0.3873 0.094 0.0299 0.049 0.0088 2.2446 | 0.059 0.0109 2.6316 0.035 0.0059 1.5667 0.066 0.0123 2.8326 0.076 0.0127 3.5748 0.055 0.0114 2.7792 0.048 0.0087 2.2642 0.057 0.0098 2.6135 0.057 0.0089 2.6648 0.072 0.0129 3.2520 0.057 0.0102 2.6424 0.012 0.0022 0.5534 1.487 0.2676 68.117 1.764 0.3175 80.806 1.728 0.3204 77.074 1.821 0.3377 81.222 1.663 0.2790 74.440 2.048 0.3436 91.674 1.760 0.3291 75.536 1.709 0.3196 73.348 1.446 0.2416 68.015 1.978 0.3305 93.039 1.325 0.2743 66.953 1.630 0.3374 82.365 1.336 0.2408 63.019 1.877 0.3383 88.538 1.888 0.3252 86.566 1.915 0.3299 87.804 1.896 0.2955 88.640 1.971 0.3072 92.146 1.830 0.3285 82.656 1.947 0.3496 87.940 j 1 1.636 0.2902 75.102 j 1.866 0.3311 85.888 0.221 0.0347 8.7412 I 0.133 0.0130 6.2888 4.301 0.7741 197.02 4.319 0.8009 192.64 4.331 0.7266 193.87 4.014 0.7506 172.27 4.656 0.7781 219.00 3.399 0.7036 171.75 4.435 0.7992 209.20 4.571 0.7874 209.58 4.952 0.7717 231.51 4.528 0.8129 204.52 4.351 0.7705 200.14 0.417 0.0345 18.909 Group : IX 125 mg/kg/day Sex MALES 1 ANIMAL 1 FBW BRAIN 1 1 (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 1 654914 1563.50 1 654921 1553.20 1 654951 555.00 1 654955 542.50 j 654965 483.60 i 654979 1512.40 1 654983 569.90 1 654986 575.00 j 654996 1508.60 2.298 0.4078 2.064 0.3731 2.159 0.3890 2.226 0.4103 2.132 0.4409 2.185 0.4264 2.139 0.3753 2.130 0.3704 2.156 0.4239 0.096 0.0170 4.1775 0.054 0.0098 2.6163 0.056 0.0101 2.5938 0.066 0.0122 2.9650 0.070 0.0145 3.2833 0.052 0.0101 2.3799 0.061 0.0107 2.8518 0.050 0.0087 2.3474 0.067 0.0132 3.1076 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.610 0.2857 70.061 1.421 0.2569 68.847 1.549 0.2791 71.746 1.543 0.2844 69.317 1.507 0.3116 70.685 1.446 0.2822 66.178 0.807 0.1416 37.728 1.364 0.2372 64.038 1.670 0.3284 77.458 HEART (Gms) %FBW %BRAIN 1.869 0.3317 81.332 1.819 0.3288 88.130 1.870 0.3369 86.614 2.121 0.3910 95.283 1.480 0.3060 69.418 2.590 0.5055 118.54 1.841 0.3230 86.068 2.012 0.3499 94.460 1.968 0.3869 91.280 KIDNEYS (Gms) %FBW %BRAIN 4.636 0.8227 201.74 4.372 0.7903 211.82 4.618 0.8321 213.90 4.895 0.9023 219.90 4.681 0.9679 219.56 4.605 0.8987 210.76 4.557 0.7996 213.04 4.308 0.7492 202.25 5.452 1.0720 252.88 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -661- ~90-Day Oral Gavage Stu\dSyubinchRraotnsi_c_T__o_x_ic_i_ty ) DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : IX 125 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES 1 1 (Gms) (Gms) %FBW (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 111 655003 1 Mean 1 S.D. 11506.10 1 2.257 0.4460 ! 1 536.98 1 2.175 0.4063 31.734 i 0.069 0.0282 0.049 0-0097 2.1710 1 1 0.062 0.0116 2.8494 0.014 0.0026 0.5854 1.643 0.3246 72.796 1.456 0.2732 66.885 0.248 0.0542 10.870 HEART (Gms) %FBW %BRAIN 1.586 0.3134 70.270 1.916 0.3573 88.139 0.303 0.0593 13.934 KIDNEYS (Gms) %FBW %BRAIN 4.240 0.8378 187.86 4.636 0.8673 213.37 0.346 0.0959 16.868 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -662- 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity ) ) DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : X 0 mg/kg/day Sex -.MALES 11 ANIMAL (Gins) LIVER 1 SPLEEN %FBW %BRAIN (Gms) %FBW %BRAIN TESTES 1 THYMUS j THYROID GLAND (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 16.824 2.9082 769.27 13.693 2.3781 625.25 15.743 2.7800 741.54 13.187 2.6056 603.80 15.095 2.5861 706.36 15.783 3.0311 737.87 17.121 2.6491 787,17 14.283 2.8635 610.12 15.690 2.7701 677.46 11.344 2.3303 549.08 1.074 0.1857 49.108 0.885 0.1537 40.411 0.960 0.1695 45.219 0.853 0.1685 39.057 0.811 0.1389 37.950 0.942 0.1809 44.039 0.952 0.1473 43.770 0.822 0.1648 35.113 1.156 0.2041 49.914 0.677 0.1391 32.769 3.893 0.6729 178.01 3.365 0.5844 153.65 3.759 0.6638 177.06 3.669 0.7250 167.99 3.715 0.6365 173.84 3.490 0.6703 163.16 3.691 0.5711 169.70 3.512 0.7041 150.02 3.681 0.6499 158.94 3.101 0.6370 150.10 0.359 0.0621 16.415 0.496 0.0861 22.648 0.274 0.0484 12.906 0.387 0.0765 17.720 0.541 0.0927 25.316 0.498 0.0956 23.282 0.621 0.0961 28.552 0.387 0.0776 16.531 0.655 0.1156 28.282 0.278 0.0571 13.456 0.024 0.0041 1.0974 0.017 0.0030 0.7763 0.021 0.0037 0.9892 0.024 0.0047 1.0989 0.024 0.0041 1.1231 0.028 0.0054 1.3090 0.027 0.0042 1.2414 0.024 0.0048 1.0252 0.030 0.0053 1.2953 0.020 0.0041 0.9681 Mean S.D. 14.876 2.6902 680.79 1.770 0.2248 80.356 0.913 0.1653 41.735 0.137 0.0212 5.6798 3.588 0.6515 164.25 0.228 0.0478 10.716 0.450 0.0808 20.511 0.134 0.0206 5.8536 0.024 0.0043 1.0924 0.004 0.0007 0.1639 Group : III 1 mg/kg/day Sex :MALES 11 ANIMAL (Gms) LIVER 1 SPLEEN %FBW %BRAIN j(Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN 654908 654913 654932 654938 654941 654946 654947 654960 13.521 2.6198 584.57 1 13.493 2.5263 627.87 j 15.900 2.8087 763.69 j 16.451 2.8393 743.38 j 13.863 2.6877 621.94 j 14.040 2.4303 645.52 j 13.017 2.6587 651.18 j 13.151 2.5625 647.83 j 0.793 0.1537 34.284 0.845 0.1582 39.321 0.761 0.1344 36.551 1.094 0.1888 49.435 0.989 0.1917 44.370 0.844 0.1461 38.805 0.637 0.1301 31.866 0.857 0.1670 42.217 2.930 0.5677 126.68 3.529 0.6607 164.22 3.830 0.6766 183.96 3.529 0.6091 159.47 3.384 0.6561 151.82 3.450 0.5972 158.62 3.359 0.6861 168.03 3.652 0.7116 179.90 0.309 0.0599 13.359 0.312 0.0584 14.518 0.364 0.0643 17.483 0.518 0.0894 23.407 0.354 0.0686 15.882 0.423 0.0732 19.448 0.266 0.0543 13.307 0.385 0.0750 18.966 0.0200.025 0.0048 1.0808 0.0037 0.9307 0.029 0.0051 1.3929 0.0220.024 0.0041 1.0845 0.0043 0.9870 0.027 0.0047 1.2414 0.0200.019 0.0039 0.9505 0.0039 0.9852 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI - 663- 90-Day Oral Gavage ;udSyubinchRraotnsic Toxicity DuPont-9478 Group : III 1 mg/kg/day Sex :MALES Organ Weight Listing Male Rats Designated for Subchronic Toxicity 1 ANIMAL I LIVER | SPLEEN ) TESTES | THYMUS | THYROID GLAND 1 | I(Gins) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gins) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 1 654984 1 14.923 2.4797 683.29 1 654995 j 12.728 2.4758 554.60 jI S1 1 Mean | 14.109 2.6089 652.39 1 S.D. 1.254 0.1403 64.449 0.764 0.1270 34.982 0.834 0.1622 36.340 0.842 0.1559 38.817 0.126 0.0226 5.2729 3.533 0.5871 161.77 3.799 0.7390 165.53 3.500 0.6491 162.00 0.255 0.0568 15.726 0.424 0.0705 19.414 0.394 0.0766 17.168 0.375 0.0690 17.295 0.072 0.0103 3.1698 0.018 0.0030 0.8242 0.027 0.0053 1.1765 0.023 0.0043 1.0654 0.004 0.0007 0.1678 Group : V 5 mg/kg/day Sex :MALES 1 ANIMAL LIVER SPLEEN TESTES THYMUS THYROID GLAND 1 (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 654907 654911 654916 654917 654959 654961 654967 654980 654998 655005 13.279 2.4918 621.09 15.581 2.5135 644.11 14.164 2.6912 608.16 16.489 2.8052 753.96 17.731 2.8548 780.76 17.017 2.6453 763.78 12.452 2.4259 573.56 16.952 2.7058 754.09 16.528 2.8128 746.52 15.559 2.7402 729.10 0.621 0.1165 29.046 0.893 0.1441 36.916 0.786 0.1493 33.748 1.014 0.1725 46.365 1.120 0.1803 49.317 0.941 0.1463 42.235 0.753 0.1467 34.684 1.112 0.1775 49.466 0.796 0.1355 35.953 0.702 0.1236 32.896 3.202 0.6009 149.77 3.803 0.6135 157.21 3.555 0.6755 152.64 3.729 0.6344 170.51 3.871 0.6232 170.45 3.879 0.6030 174.10 3.281 0.6392 151.13 4.728 0.7547 210.32 3.268 0.5562 147.61 3.682 0.6485 172.54 0.529 0.0993 24.743 0.457 0.0737 18.892 0.420 0.0798 18.033 0.646 0.1099 29.538 0.602 0.0969 26.508 0.519 0.0807 23.294 0.355 0.0692 16.352 0.601 0.0959 26.735 0.313 0.0533 14.137 0.357 0.0629 16.729 0.027 0.0051 1.2629 0.028 0.0045 1.1575 0.031 0.0059 1.3310 0.026 0.0044 1.1888 0.028 0.0045 1.2329 0.025 0.0039 1.1221 0.023 0.0045 1.0594 0.022 0.0035 0.9786 0.025 0.0043 1.1292 0.025 0.0044 1.1715 Mean S.D. 15.575 2.6687 697.51 1.744 0.1475 76.846 0.874 0.1492 39.063 3.700 0.6349 165.63 0.480 0.0822 21.496 0.171 0.0218 7.2788 I 0.442 0.0529 18.827 1 0.117 0.0180 5.3033 0.026 0.0045 1.1634 0.003 0.0006 0.1008 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -664- 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : VII 25 mg/kg/day Sex :MALES 1 ANIMAL j LIVER 1 SPLEEN 1 TESTES 1 THYMUS 1 THYROID GLAND | 1 (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 1 654922 j 654923 j 654930 1 654940 1 654952 1 654958 j 654975 I 654989 1 655001 I 655006 j I 1 Mean j S.D. 16.414 2.9543 751.90 16.965 3.1457 756.69 18.546 3.1112 830.17 15.957 2.9837 684.85 17.594 2.9402 827.56 14.340 2.9683 724.61 17.187 3.0973 810.71 16.625 2.8639 762.27 20.773 3.2372 971.15 17.787 3.1934 803.39 17.219 3.0495 792.33 1.693 0.1237 78.215 0.760 0.1368 34.814 0.822 0.1524 36.664 1.134 0.1902 50.761 0.970 0.1814 41.631 0.888 0.1484 41.769 0.895 0.1853 45.225 0.968 0.1744 45.660 0.980 0.1688 44.934 0.877 0.1367 41.000 0.898 0.1612 40.560 0.919 0.1636 42.302 0.102 0.0196 4.6142 3.552 0.6393 162.71 3.816 0.7076 170.21 4.003 0.6715 179.19 3.522 0.6586 151.16 3.328 0.5561 156.54 3.312 0.6856 167.36 3.706 0.6679 174.81 3.395 0.5848 155.66 4.203 0.6550 196.49 4.131 0.7417 186.59 3.697 0.6568 170.07 0.330 0.0543 14.477 0.269 0.0484 12.322 0.370 0.0686 16.503 0.523 0.0877 23.411 0.366 0.0684 15.708 0.339 0.0567 15.945 0.437 0.0905 22.082 0.486 0.0876 22.925 0.673 0.1159 30.857 0.647 0.1008 30.248 0.462 0.0829 20.867 0.457 0.0808 21.087 0.131 0.0204 6.1679 0.023 0.0041 1.0536 0.027 0.0050 1.2043 0.031 0.0052 1.3876 0.026 0.0049 1.1159 0.031 0.0052 1.4581 0.027 0.0056 1.3643 0.022 0.0040 1.0377 0.023 0.0040 1.0546 0.022 0.0034 1.0285 0.026 0.0047 1.1743 0.026 0.0046 1.1879 0.003 0.0007 0.1611 Group : IX 125 mg/kg/day Sex :MALES I ANIMAL 1 (Gms) LIVER %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN 1 654914 1 654921 j 654951 1 654955 I 654965 1 654979 1 654983 1 654986 1 654996 22.509 3.9945 979.50 21.736 3.9291 1053.1 22.546 4.0623 1044.3 23.398 4.3130 1051.1 19.727 4.0792 925.28 21.382 4.1729 978.58 20.456 3.5894 956.33 22.395 3.8948 1051.4 26.082 5.1282 1209.7 0.921 0.1634 40.078 0.949 0.1715 45.979 0.862 0.1553 39.926 1.449 0.2671 65.094 0.959 0.1983 44.981 1.000 0.1952 45.767 0.732 0.1284 34.222 0.928 0.1614 43.568 0.943 0.1854 43.738 3.548 0.6296 154.40 3.541 0.6401 171.56 4.169 0.7512 193.10 3.883 0.7158 174.44 3.651 0.7550 171.25 3.302 0.6444 151.12 2.192 0.3846 102.48 3.976 0.6915 186.67 3.890 0.7648 180.43 0.618 0.1097 26.893 0.289 0.0522 14.002 0.443 0.0798 20.519 0.725 0.1336 32.570 0.378 0.0782 17.730 0.265 0.0517 12.128 0.474 0.0832 22.160 0.431 0.0750 20.235 0.451 0.0887 20.918 0.026 0.0046 1.1314 0.023 0.0042 1.1143 0.023 0.0041 1.0653 0.027 0.0050 1.2129 0.019 0.0039 0.8912 0.023 0.0045 1.0526 0.020 0.0035 0.9350 0.022 0.0038 1.0329 0.028 0.0055 1.2987 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -665- 90-Day Oral Gava_g_e_S_t_uIdSyuibnchRraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Male Rats Designated for Subchronic Toxicity Group : IX 125 mg/kg/day Sex :MALES 1 ANIMAL 1 1 1(Gms) LIVER 1 SPLEEN %FBW %BRAIN (Gms) %FBW %BRAIN TESTES 1 THYMUS 1 THYROID GLAND (Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 1 655003 I1 | Mean 1 S.D. 1 19.526 3.8581 865.13 1 I 11 | 21.976 4.1022 1011.4 1 1 1.928 0.4098 93.853 1 0.891 0.1761 39.477 0.963 0.1802 44.283 0.186 0.0367 8.1682 3.371 0.6661 149.36 1 0.477 0.0943 21.134 1 0.022 0.0043 0.9747 11 3.552 0.6643 163.48 1 0.455 0.0846 20.829 1 0.023 0.0043 1.0709 0.552 0.1104 26.042 1 0.138 0.0246 5.8581 1 0.003 0.0006 0.1245 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight - 666- 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity DuPont-9478 Organ Weight Listing Male Rats Designated for Recovery Group : I 0 mg/kg/day Sex MALES | ANIMAL | FBW | BRAIN | ADRENAL GLANDS | EPIDIDYMIDES | HEART | KIDNEYS | | 1 (Gms) [(Gms) %FBW | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN j 654909 654910 654915 654924 654927 654943 654956 654992 654994 578.30 691.50 725.90 631.40 674.60 605.80 551.90 656.30 521.10 2.124 0.3673 2.184 0.3158 2.295 0.3162 2.074 0.3285 2.356 0.3492 2.106 0.3476 2.124 0.38,49 2.123 0.3235 2.065 0.3963 0.041 0.0071 1.9303 0.055 0.0080 2.5183 0.062 0.0085 2.7015 0.041 0.0065 1.9769 0.060 0.0089 2.5467 0.060 0.0099 2.8490 0.068 0.0123 3.2015 0.050 0.0076 2.3552 0.060 0.0115 2.9056 1.533 0.2651 72.175 1.706 0.2467 78.114 1.611 0.2219 70.196 1.479 0.2342 71.311 1.496 0.2218 63.497 1.398 0.2308 66.382 1.717 0.3111 80.838 1.329 0.2025 62.600 1.344 0.2579 65.085 1.733 0.2997 81.591 1.907 0.2758 87.317 1.857 0.2558 80.915 1.728 0.2737 83.317 2.037 0.3020 86.460 1.615 0.2666 76.686 1.854 0.3359 87.288 1.931 0.2942 90.956 1.530 0.2936 74.092 3.825 0.6614 180.08 | 4.529 0.6550 207.37 j 4.260 0.5869 185.62 j 4.031 0.6384 194.36 4.138 0.6134 175.64 3.879 0.6403 184.19 3.232 0.5856 152.17 4.033 0.6145 189.97 3.269 0.6273 158.31 Mean S.D. 626.31 2.161 0.3477 67.783 0.100 0.0298 0.055 0.0089 2.5539 0.009 0.0020 0.4205 1.513 0.2436 70.022 0.144 0.0319 6.3647 1.799 0.2886 83.180 0.161 0.0238 5.4505 3.911 0.6248 180.86 0.428 0.0271 17.182 Group : IX 125 mg/kg/day Sex MALES 1 ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | EPIDIDYMIDES | HEART 1 KIDNEYS 1 1 1 (Gms) 1(Gms) %FBW j (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN j 654942 654957 654973 654974 654976 654977 654978 654985 654990 620.80 616.90 642.70 673.00 597.10 492.60 552.60 475.30 667.90 2.113 0.3404 2.080 0.3372 2.202 0.3426 2.081 0.3092 2.192 0.3671 2.180 0.4425 2.091 0.3784 1.995 0.4197 2.044 0.3060 0.041 0.0066 1.9404 0.039 0.0063 1.8750 0.064 0.0100 2.9064 0.062 0.0092 2.9793 0.051 0.0085 2.3266 0.042 0.0085 1.9266 0.033 0.0060 1.5782 0.048 0.0101 2.4060 0.050 0.0075 2.4462 1.548 0.2494 73.261 1.451 0.2352 69.760 1.582 0.2461 71.844 1.503 0.2233 72.225 1.481 0.2480 67.564 1.530 0.3106 70.183 1.218 0.2204 58.250 1.603 0.3373 80.351 1.516 0.2270 74.168 1.788 0.2880 84.619 1.864 0.3022 89.615 1.847 0.2874 83.878 2.076 0.3085 99.760 1.742 0.2917 79.471 1.453 0.2950 66.651 1.617 0.2926 77.331 1.553 0.3267 77.845 2.136 0.3198 104.50 4.126 0.6646 195.27 4.567 0.7403 219.57 4.389 0.6829 199.32 4.187 0.6221 201.20 3.784 0.6337 172.63 3.039 0.6169 139.40 3.551 0.6426 169.82 3.212 0.6758 161.00 4.213 0.6308 206.12 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -667- 0-Day Oral Gavage StudyuibnchRraotns_ic_T__o_x_ic_i_ty DuPont-9478 Organ Weight Listing Male Rats Designated for Recovery Group : IX 125 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW I BRAIN 1 1 (Gms) 1(Gms) %FBW 654991 1759.70 1 2.131 0.2805 i! 1 1 Mean 1609.86 1 2.111 0.3524 S.D. 85.864 0.067 0.0508 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.057 0.0075 2.6748 0.049 0.0080 2.3060 0.010 0.0015 0.4682 EPIDIDYMIDES I HEART (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 1.366 0.1798 64.101 1 1 1.480 0.2477 70.171 0.114 0.0454 5.9824 2.337 0.3076 109.67 1.841 0.3020 87.334 0.276 0.0136 13.549 KIDNEYS I (Gms) %FBW %BRAIN 1 4.333 0.5704 203.33 1 11 3.940 0.6480 186.77 1 0.520 0.0459 24.848 1 FBW - Final Body Weight "90-Day O_r_a_l_G_a_v_a_g_eiSStuubdcyhrionnRicatTsoxicity ) DuPont-9478 Organ Weight Listing Male Rats Designated for Recovery Group : I 0 mg/kg/day Sex :MALES 1 ANIMAL 1 LIVER 1 SPLEEN 1 TESTES 1 THYMUS 1 THYROID GLAND | j j1 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN | 654909 654910 654915 654924 654927 654943 654956 654992 654994 13.874 2.3991 653.20 19.106 2.7630 874.82 19.298 2.6585 840.87 16.367 2.5922 789.15 17.544 2.6007 744.65 15.294 2.5246 726.21 13.066 2.3675 615.16 14.895 2.2695 701.60 12.566 2.4114 608.52 0.788 0.1363 37.100 1.040 0.1504 47.619 1.028 0.1416 44.793 0.748 0.1185 36.066 0.916 0.1358 38.879 0.723 0.1193 34.330 0.866 0.1569 40.772 0.783 0.1193 36.882 0.872 0.1673 42.228 3.814 0.6595 179.57 4.242 0.6134 194.23 3.522 0.4852 153.46 3.659 0.5795 176.42 3.520 0.5218 149.41 3.819 0.6304 181.34 3.512 0.6363 165.35 3.423 0.5216 161.23 3.382 0.6490 163.78 0.159 0.0275 7.4859 0.374 0.0541 17.125 0.139 0.0191 6.0566 0.296 0.0469 14.272 0.149 0.0221 6.3243 0.170 0.0281 8.0722 0.155 0.0281 7.2976 0.234 0.0357 11.022 0.322 0.0618 15.593 0.021 0.0036 0.9887 0.026 0.0038 1.1905 0.031 0.0043 1.3508 0.037 0.0059 1.7840 0.031 0.0046 1.3158 0.031 0.0051 1.4720 0.030 0.0054 1.4124 0.039 0.0059 1.8370 0.031 0.0059 1.5012 Mean S.D. 15.779 2.5096 728.24 2.481 0.1587 94.614 0.863 0.1384 39.852 0.115 0.0176 4.3789 3.655 0.5885 169.42 0.270. 0.0643 14.492 0.222 0.0359 10.361 0.088 0.0149 4.2803 0.031 0.0050 1.4280 0.005 0.0009 0.2668 Group : XX 125 mg/kg/day Sex :MALES | ANIMAL I LIVER | SPLEEN | TESTES | THYMUS | THYROID GLAND | | I(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 654942 654957 654973 654974 654976 654977 654978 654985 654990 16.631 2.6790 787.08 | 0.872 0.1405 41.268 14.671 2.3782 705.34 | 0.916 0.1485 44.038 14.447 2.2479 656.09 \ 0.904 0.1407 41.054 17.388 2.5837 835.56 | 0.940 0.1397 45.171 13.934 2.3336 635.68 | 0.773 0.1295 35.265 10.701 2.1724 490.87 j 0.635 0.1289 29.128 13.068 2.3648 624.96 j 0.694 0.1256 33.190 12.493 2.6284 626.22 | 0.823 0.1732 41.253 17.770 2.6606 869.37 | 0.924 0.1383 45.205 3.560 0.5735 168.48 3.385 0.5487 162.74 3.715 0.5780 168.71 3.480 0.5171 167.23 3.458 0.5791 157.76 3.436 0.6975 157.61 3.542 0.6410 169.39 3.260 0.6859 163.41 3.364 0.5037 164.58 0.414 0.0667 19.593 0.317 0.0514 15.240 0.388 0.0604 17.620 0.414 0.0615 19.894 0.288 0.0482 13.139 0.251 0.0510 11.514 0.345 0.0624 16.499 0.291 0.0612 14.586 0.314 0.0470 15.362 0.029 0.0047 1.3725 0.033 0.0053 1.5865 0.025 0.0039 1.1353 0.034 0.0051 1.6338 0.026 0.0044 1.1861 0.025 0.0051 1.1468 0.040 0.0072 1.9130 0.023 0.0048 1.1529 0.026 0.0039 1.2720 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBi -669- 50-Day Oral Gavage StudSyubinchRraotnsic Toxicity DuPont-9478 Organ Weight Listing Male Rats Designated for Recovery Group : IX 125 mg/kg/day Sex :MALES 1 ANIMAL 1 LIVER 1 SPLEEN 1 TESTES 1 THYMUS 1 THYROID GLAND 1 1 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 1 654991 I i j Mean 1 S.D. 19.568 2.5758 918.25 | 0.916 0.1206 42.985 15.067 2.4624 714.94 0.840 0.1385 39.856 2.727 0.1840 133.73 1 0.106 0.0148 5.4785 3.398 O.4473 159.46 3.460 0.5772 163.94 0.125 0.0796 4.5266 0.362 0.0477 16.987 0.338 0.0557 16.044 0.056 0.0074 2.6500 0.028 0.0037 1.3139 | I1 0.029 0.0048 1.3713 | 0.005 0.0010 0.2603 | Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -670- Company Sanitized. Does not contain TSCA CBI 3-Day avage StudSyuibnchRraotnsic Toxi_ci_t_y Organ Weight Listing Male Rats Designated for Satellite Evaluation (10-Day Sacrifice) Group : 1 0 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW 1 LIVER 1 1 (Gms) 1(Gms) %FBW 655115 1254.1 1 11.566 655119 1241.7 1 9.945 655124 1266.0 1 11.053 655135 1222.4 1 9.158 655137 1257.7 1 10.375 11 1 1 Mean |248.38 1 10.419 S.D. 16.953 0.940 4.552 4.115 4.155 4.118 4.026 4.193 0.206 Group : III 1 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 655114 655118 655120 655132 655139 247.2 247.9 226.2 242.8 259.2 9.848 10.209 9.572 9.991 11.460 3.984 4.118 4.232 4.115 4.421 Mean S.D. 244.66 10.216 4.174 11.964 0.733 0.164 | | | | FBW - Final Body Weight -671- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI "90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity Organ Weight Listing Male Rats Designated for Satellite Evaluation (10-Day Sacrifice) Group : V 5 mg/kg/day Sex :MALES | ANIMAL I FBW j LIVER | j (Gms) j(Gms) %FBW 655121 655126 655127 655131 655138 271.9 209.0 249.7 253.9 243.8 12.100 8.676 9.924 11.717 9.680 4.450 4.151 3.974 4.615 3.970 Mean S.D. 245.66 10.419 4.232 23.023 1.444 0.290 Group : VII 25 mg/kg/day Sex MALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 1 655112 1 655116 1 655125 1 655129 j 655133 11 1 Mean j S.D. 212.9 254.1 238.0 251.9 249.9 9.320 10.352 10.490 11.846 11.508 241.36 10.703 17.085 1.004 4.378 4.074 4.408 4.703 4.605 4.433 0.242 1 j FBW - Final Body Weight - 672- DuPont-9478 DO-Day Oral Gavage StudSyuibnchRraotnsic Toxicity ) Organ Weight Listing Male Rats Designated for Satellite Evaluation (10-Day Sacrifice) Group : IX 125 mg/kg/day Sex :MALES I ANIMAL I FBW | LIVER 1 1 (Gms) i(Gms) %FBW 655113 I238.1 655122 I276.2 655123 I245.5 655128 237.4 I655130 267.5 Mean 252.94 S.D. \ 17.819 12.784 5.369 16.404 5.939 12.838 5.229 13.321 5.611 15.563 5.818 14.182 5.593 1.684 0.297 | > DuPont-9478 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight - 673 - Company Sanitized. Does not contain TSCA CBI ~90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity Organ Weight Listing Male Rats Designated for Satellite Evaluation (Final Sacrifice) Group : I 0 mg/kg/day Sex MALES 1 ANIMAL j FBW 1 LIVER 1 1 (Gms) 1(Gms) %FBW 1 654919 j551.10 1 19.363 3.5135 1 654939 j743.60 1 24.134 3.2456 j 654966 j489.70 j 12.940 2.6424 1 654971 j575.70 j 18.670 3.2430 11 654997 1 1I 655.10 1 j 23.031 jI 3.5156 1 Mean |603.04 j 19.628 3.2320 1 S.D. 98.436 4.405 0.3562 Group : III 1 mg/kg/day Sex MALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 1 654904 1 654945 j 654948 1 654954 jI 654988 i j Mean j S.D. 616.70 572.60 738.30 690.90 613.20 646.34 66.814 18.945 3.0720 17.032 2.9745 24.199 3.2777 24.931 3.6085 17.496 2.8532 20.521 3.1572 3.768 0.2963 1 j 1 j FBW - Final Body Weight -674- ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI "90-Day Oral Gavage~Stu^dSyuibnchRraotnsic Toxicity Organ Weight Listing Male Rats Designated for Satellite Evaluation (Final Sacrifice) Group : V 5 mg/kg/day Sex :MALES 11 ANIMAL FBW (Gms) (Gms) LIVER %FBW 1 654918 1 654926 1 654969 j 654970 11 654981 1 Mean j S.D. 726.80 722.10 582.00 542.40 589.10 632.48 85.838 23.418 3.2221 24.295 3.3645 19.389 3.3314 15.430 2.8448 17.283 2.9338 19.963 3.1393 3.833 0.2364 1 j Group : VII 25 mg/kg/day Sex :MALES 11 ANIMAL FBW (Gms) (Gms) LIVER %FBW 1 654912 j 654920 j 654933 1 654934 11j 654964 1 Mean 1 S.D. 662828..0500 816.80 618.70 723.20 693.84 81.778 19.039 3.0585 21.986 3.1956 28.040 3.4329 18.824 3.0425 25.118 3.4732 22.601 3.2405 3.976 0.2034 1 j FBW - Final Body Weight -675- ) DuPont-9478 90-Day Oral Gavage !udyubinchRraotnsic Toxicity Organ Weight Listing Male Rats Designated for satellite Evaluation (Final Sacrifice) Group : IX 125 mg/kg/day Sex :MALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW j 654905 1 654931 j 654937 1 654962 1 654982 11 j Mean 1 S.D. 801.50 692.30 704.70 623.30 667.90 697.94 65.719 28.596 3.5678 21.588 3.1183 20.829 2.9557 18.843 3.0231 22.940 3.4346 22.559 3.2199 3.686 0.2674 1 j DuPont-9478 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -676- ?0-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity ) ) DuPont-9478 Organ. Weight Listing Female Rats Designated for Subchronic Toxicity Group : II 0 mg/kg/day Sex :FEMALES 11 ANIMAL FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 286.50 301.70 292.60 302.90 322.50 266.80 310.80 261.10 284.90 238.50 1.957 0.6831 2.094 0.6941 1.964 0.6712 2.002 0.6609 2.043 0.6335 1.982 0.7429 1.948 0.6268 1.879 0.7196 1.925 0.6757 1.873 0.7853 0.074 0.0258 3.7813 0.072 0.0239 3.4384 0.060 0.0205 3.0550 0.098 0.0324 4.8951 0.086 0.0267 4.2095 0.080 0.0300 4.0363 0.081 0.0261 4.1581 0.059 0.0226 3.1400 0.074 0.0260 3.8442 0.076 0.0319 4.0577 Mean S.D. 286.83 1.967 0.6893 25.304 0.068 0.0488 0.076 0.0266 3.8616 0.012 0.0039 0.5481 HEART (Gms) %FBW %BRAIN 1.971 0.6880 100.72 1.286 0.4263 61.414 1.141 0-3900 58.096 1.277 0.4216 63.786 1.243 0.3854 60.842 1.046 0.3921 52.775 1.230 0.3958 63.142 1.042 0.3991 55.455 1.135 0.3984 58.961 0.859 0.3602 45.862 1.223 0.4257 62.105 0.294 0.0940 14.598 KIDNEYS (Gms) %FBW %BRAIN 2.378 0.8300 121.51 2.252 0.7464 107.55 2.174 0.7430 110.69 2.246 0.7415 112.19 2.521 0.7817 123.40 2.201 0.8250 111.05 2.459 0.7912 126.23 2.220 0.8502 118.15 2.068 0.7259 107.43 1.869 0.7836 99.786 2.239 0.7819 113.80 0.188 0.0428 8.3064 LIVER 1 (Gms) %FBW %BRAIN | 8.877 3.0984 453.60 8.737 2.8959 417.24 7.403 2.5301 376.93 8.256 2.7257 412.39 8.859 2.7470 433.63 7.413 2.7785 374.02 8.359 2.6895 429.11 7.334 2.8089 390.31 7.526 2.6416 390.96 6.280 2.6331 335.29 7.904 2.7549 401.35 0.849 0.1580 34.727 Group : IV 1 mg/kg/day Sex -.FEMALES 1 ANIMAL 1 FBW BRAIN 1 1 (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 1 655013 1299.40 I 655033 303.60 1 655040 1293.10 1 655041 276.10 j 655044 317.20 1 655086 1243.30 655089 317.90 \ 655090 323.50 2.040 0.6814 2.052 0.6759 1.842 0.6285 2.028 0.7345 2.059 0.6491 1.977 0.8126 1.872 0.5889 2.027 0.6266 0.079 0.0264 3.8725 0.094 0.0310 4.5809 0.040 0.0136 2.1716 0.067 0.0243 3.3037 0.032 0.0101 1.5542 0.071 0.0292 3.5913 0.074 0.0233 3.9530 0.055 0.0170 2.7134 HEART (Gms) %FBW %BRAIN 1.073 0.3584 52.598 1.136 0.3742 55.361 1.207 0.4118 65.527 1.092 0.3955 53.846 1.073 0.3383 52.113 1.023 0.4205 51.745 1.053 0.3312 56.250 1.137 0.3515 56.093 KIDNEYS (Gms) %FBW %BRAIN 2.252 0.7522 110.39 2.012 0.6627 98.051 2.253 0.7687 122.31 2.557 0.9261 126.08 1.928 0.6078 93.638 1.766 0.7259 89.327 2.346 0.7380 125.32 2.088 0.6454 103.01 LIVER 1 (Gms) %FBW %BRAIN i 8.222 2.7462 403.04 8.763 2.8864 427.05 8.498 2.8994 461.35 8.085 2.9283 398.67 7.659 2.4146 371.98 6.383 2.6235 322.86 10.197 3.2076 544.71 8.578 2.6516 423.19 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -677- wH5a)^raroavag^tudSyubinchRraotnsic Toxicity ) ) DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : IV 1 mg/kg/day Sex :FEMALES 11 ANIMAL 1 FBW 1 BRAIN 1 ADRENAL GLANDS | 1 (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN | (Gms) %FBW %BRAIN | (Gms) LIVER 1 %FBW %BRAIN | 1 655091 1302.60 1 1.933 0.6388 11 655108 1269.30 1 1.946 0.7226 1! 1I 1 1 Mean |294.60 1 1.978 0.6759 1 S.D. 125.107 1 0.077 0.0656 0.066 0.0218 3.4144 | 110.053 0.0X97 2.7235 j 0.063 0.0216 3.1878 | 0.019 0.0067 0.9046 | 1.228 0.4058 63.528 1.062 0.3944 54.573 1.108 0.3781 56.163 0.067 0.0319 4.7035 2.318 0.7660 119.92 1.951 0.7245 100.26 2.147 0.7317 108.83 0.239 0.0872 13.790 8.370 2.7660 433.01 | 17.484 2.7791 384.58 | 1 8.224 2.7903 417.04 | 0.982 0.2122 58.824 | Group : VI 5 mg/kg/day Sex :FEMALES 11 ANIMAL FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 1 655020 301.60 1 655029 279.90 1 655034 259.10 1 655038 292.70 1 655039 301.30 1 655042 339.80 1 655054 252.30 1 655066 308.10 1 655067 291.40 11 655087' 314.70 I 1 Mean 294.09 1 S.D. 25.820 1.931 0.6403 1.831 0.6542 1.758 0.6785 2.025 0.6918 1.989 0.6601 1.950 0.5739 1.948 0.7721 1.959 0.6358 1.890 0.6486 2.030 0.6451 1.931 0.6600 0.085 0.0502 0.063 0.0209 3.2626 0.068 0.0243 3.7138 0.056 0.0216 3.1854 0.082 0.0280 4.0494 0.060 0.0199 3.0166 0.087 0.0256 4.4615 0.064 0.0254 3.2854 0.070 0.0227 3.5733 0.075 0.0257 3.9683 0.077 0.0245 3.7931 0.070 0.0239 3.6309 0.010 0.0025 0.4529 HEART (Gms) %FBW %BRAIN 0.987 0.3273 51.113 1.078 0.3851 58.875 0.941 0.3632 53.527 1.111 0.3796 54.864 1.101 0.3654 55.354 1.206 0.3549 61.846 1.094 0.4336 56.160 1.312 0.4258 66.973 1.177 0.4039 62.275 1.292 0.4105 63.645 1.130 0.3849 58.463 0.120 0.0336 5.0742 KIDNEYS (Gms) %FBW %BRAIN 2.149 0.7125 111.29 2.021 0.7220 110.38 1.845 0.7121 104.95 2.116 0.7229 104.49 2.170 0.7202 109.10 2.339 0.6883 119.95 2.090 0.8284 107.29 2.186 0.7095 111.59 2.139 0.7340 113.17 2.491 0.7915 122.71 2.155 0.7342 111.49 0.173 0.0426 5.9315 LIVER 1 (Gms) %FBW %BRAIN | 8.880 2.9443 459.87 7.202 2.5731 393.34 6.924 2.6723 393.86 8.505 2.9057 420.00 7.750 2.5722 389.64 9.454 2.7822 484.82 7.625 3.0222 391.43 8.270 2.6842 422.15 7.990 2.7419 422.75 9.248 2.9387 455.57 8.185 2.7837 423.34 0.845 0.1615 33.481 Company Sanitized. Does not contain TSCA FBW - Final Body Weight O CD ~90-Day Oral Gavage StjudSyubinchRraotnsic Toxicity DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : VIII 25 mg/kg/day Sex :FEMALES ANIMAL FBW BRAIN (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 306.70 305.60 264.90 279.50 278.20 305.30 297.00 351.30 317.90 268.80 1.958 0.6384 1.998 0.6538 1.895 0.7154 2.107 0.7538 2.042 0.7340 1.974 0.6466 2.108 0.7098 2.069 0.5890 1.855 0.5835 2.019 0.7511 0.073 0.0238 3.7283 0.056 0.0183 2.8028 0.056 0.0211 2.9551 0.067 0.0240 3.1799 0.063 0.0226 3.0852 0.064 0.0210 3.2421 0.075 0.0253 3.5579 0.067 0.0191 3.2383 0.062 0.0195 3.3423 0.070 0.0260 3.4671 Mean S.D. 297.52 2.003 0.6775 26.045 0.085 0.0638 0.065 0.0221 3.2599 0.006 0.0027 0.2784 HEART 1 KIDNEYS (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 1.060 0.3456 54.137 1.293 0.4231 64.715 1.012 0.3820 53.404 1.069 0.3825 50.736 1.090 0.3918 53.379 1.159 0.3796 58.713 1.173 0.3949 55.645 1.399 0.3982 67.617 1.275 0.4011 68.733 1.076 0.4003 53.294 2.627 0.8565 134.17 2.347 0.7680 117.47 2.134 0.8056 112.61 2.234 0.7993 106.03 2.301 0.8271 112.68 2.353 0.7707 119.20 2.864 0.9643 135.86 2.897 0.8247 140.02 2.529 0.7955 136.33 2.243 0.8344 111.09 1.161 0.3899 58.037 0.125 0.0200 6.5924 2.453 0.8246 122.55 0.267 0.0564 12.670 .LIVER 1 (Grns) %FBW %BRAIN | 10.728 3.4979 547.91 9.551 3.1253 478.03 7.515 2.8369 396.57 8.585 3.0716 407.45 8.310 2.9871 406.95 9.671 3.1677 489.92 8.930 3.0067 423.62 10.928 3.1107 528.18 9.605 3.0214 517.79 8.475 3.1529 419.76 9.230 3.0978 461.62 1.076 0.1713 57.204 Group : X 125 mg/kg/day Sex :FEMALES 11 ANIMAL 1 FBW j BRAIN 1 ADRENAL GLANDS | 1 (Gms) j(Gms) %FBW | (Gms) %FBW %BRAIN | (Gms) HEART 1 KIDNEYS 1 %FBW %BRAIN j (Gms) %FBW %BRAIN | (Gms) LIVER 1 %FBW %BRAIN j 655007 655023 655026 655052 655053 655063 655092 655095 655097 283.00 282.70 283.10 277.80 305.90 251.50 299.40 317.10 294.80 1.923 0.6795 1.860 0.6579 2.001 0.7068 2.076 0.7473 2.126 0.6950 1.912 0.7602 2.031 0.6784 2.249 0.7092 1.850 0.6275 0.070 0.0247 3.6401 0.050 0.0177 2.6882 0.077 0.0272 3.8481 0.063 0.0227 3.0347 0.097 0.0317 4.5626 0.066 0.0262 3.4519 0.080 0.0267 3.9389 0.083 0.0262 3.6905 0.062 0.0210 3.3514 1.232 0.4353 64.067 1.064 0.3764 57.204 1.172 0.4140 58.571 1.094 0.3938 52.697 1.235 0.4037 58.090 1.002 0.3984 52.406 1.143 0.3818 56.278 1.191 0.3756 52.957 1.186 0.4023 64.108 2.522 0.8912 131.15 2.159 0.7637 116.08 2.496 0.8817 124.74 2.563 0.9226 123.46 2.435 0.7960 114.53 2.079 0.8266 108.73 2.464 0.8230 121.32 3.048 0.9612 135.53 2.306 0.7822 124.65 11.585 4.0936 602.44 10.675 3.7761 573.92 10.693 3.7771 534.38 12.457 4.4842 600.05 12.127 3.9644 570.41 10.581 4.2072 553.40 10.646 3.5558 524.18 13.348 4.2094 593.51 12.171 4.1286 657.89 FEW - Final Body Weight Company Sanitized. Does not contain TSCA CBI - 679- c90-Day Oral Gavage tudSyuibnchRraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : X 125 mg/kg/day Sex FEMALES 1 ANIMAL 1 FBW BRAIN 1 1 (Gms) 1(Gms) %FBW 1 655103 I1 1 Mean 1 S.D. 1294.30 1I 288.96 117.911 1 2.063 0.7010 1 1 2,009 0.6963 1 0.126 0.0391 ADRENAL GLANDS I HEART (Gms) %FBW %BRAIN 1 (Gms) %FBW %BRAIN 0.081 0.0275 3.9263 1 11 0.073 0.0252 3.6133 0.013 0.0039 0.5220 1.184 0.4023 57.392 1.150 0.3984 57.377 0.075 0.0182 4.2082 KIDNEYS (Gms) %FBW %BRAIN 2.551 0.8668 123.65 2.462 0.8515 122.38 0.265 0.0640 7.8306 LIVER i (Gms) %FBW %BRAIN j 10.851 3.6871 525.98 j 11 11.513 3.9883 573.62 j 0.972 0.2870 41.766 j Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -680- "90-Day Oral Gavage StujdSyubinchRraotnsic Toxicity DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : II 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS 1 THYROID GLAND 1 UTERUS 1 1 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 655016 0.131 0.0457 6.6939 655025 0.116 0.0384 5.5396 655031 0.143 0.0489 7.2811 655032 0.167 0.0551 8.3417 655036 0.163 0.0505 7.9785 655079 0.144 0.0540 7.2654 655083 0.159 0.0512 8.1622 655098 0.134 0.0513 7.1315 655099 1 0.135 0.0474 7.0130 655107 1 0.119 0.0499 6.3534 11 Mean j 0.141 0.0492 7.1760 S.D. j 0.018 0.0047 0.8570 0.634 0.2213 32.397 0.614 0.2035 29.322 0.583 0.1992 29.684 0.715 0.2361 35.714 0.650 0.2016 31.816 0.618 0.2316 31.181 0.598 0.1924 30.698 0.466 0.1785 24.800 0.461 0.1618 23.948 0.449 0.1883 23.972 0.579 0.2014 29.353 0.090 0.0233 3.9433 0.290 0.1012 14.819 0.242 0.0802 11.557 0.372 0.1271 18.941 0.395 0.1304 19.730 0.513 0.1591 25.110 0.312 0.1169 15.742 0.373 0.1200 19.148 0.377 0.1444 20.064 0.327 0.1148 16.987 0.311 0.1304 16.604 0.351 0.1225 17.870 0.074 0.0219 3.6447 0.022 0.0077 1.1242 ! 0.018 0.0060 0.8596 0.022 0.0075 1.1202 0.021 0.0069 1.0490 0.018 0.0056 0.8811 0.020 0.0075 1.0091 0.020 0.0064 1.0267 0.018 0.0069 0.9580 0.026 0.0091 1.3506 0.015 0.0063 0.8009 0.818 0.2855 41.799 0.708 0.2347 33.811 0.937 0.3202 47.709 0.944 0.3117 47.153 0.542 0.1681 26.530 0.525 0.1968 26.488 0.589 0.1895 30.236 0.549 0.2103 29.218 0.588 0.2064 30.545 0.841 0.3526 44.901 0.020 0.0070 1.0179 0.003 0.0010 0.1592 0.704 0.2476 35.839 0.168 0.0645 8.6153 Group : XV 1 mg/kg/day Sex -.FEMALES | ANIMAL I OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS | i I(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 1 655013 j 655033 j 655040 1 655041 1 655044 j 655086 j 655089 i 655090 0.153 0.0511 7.5000 0.169 0.0557 8.2359 0.107 0.0365 5.8089 0.095 0.0344 4.6844 0.133 0.0419 6.4594 0.158 0.0649 7.9919 0.140 0.0440 7.4786 0.139 0.0430 6.8574 0.590 0.1971 28.922 0.728 0.2398 35.478 0.462 0.1576 25.081 0.523 0.1894 25.789 0.523 0.1649 25.401 0.465 0.1911 23.520 0.599 0.1884 31.998 0.621 0.1920 30.636 0.326 0.1089 15.980 0.360 0.1186 17.544 0.180 0.0614 9.7720 0.242 0.0876 11.933 0.161 0.0508 7.8193 0.256 0.1052 12.949 0.305 0.0959 16.293 0.350 0.1082 17.267 0.014 0.0047 0.6863 0.024 0.0079 1.1696 0.024 0.0082 1.3029 0.022 0.0080 1.0848 0.020 0.0063 0.9713 0.017 0.0070 0.8599 0.016 0.0050 0.8547 0.017 0.0053 0.8387 0.720 0.2405 35.294 1.051 0.3462 51.218 0.788 0.2689 42.780 0.816 0.2955 40.237 0.662 0.2087 32.152 1.086 0.4464 54.932 0.728 0.2290 38.889 0.542 0.1675 26.739 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI - 681- 90-Day Oral G_a_v_a_g_e_S_tuJSdyubicnhRroantsic Toxicity ) DuPont-9478 Group IV 1 mg/kg/day Sex -.FEMALES Organ Weight Listing Female Rats Designated for Subchronic Toxicity 1 ANIMAL 1 OVARIES | SPLEEN | THYMUS I THYROID GLAND 1 UTERUS 1 1 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Grns) %FBW %BRAIN |(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 1 655091 0.123 0.0406 6.3632 1 655108 0.104 0.0386 5.3443 I1 I1 1 Mean 1 0.132 0.0451 6.6724 1 S.D. j 0.025 0.0095 1.1622 0.584 0.1930 30.212 0.230 0.0760 11.899 0.400 0.1485 20.555 0.257 0.0954 13.207 1 1 0.550 0.1862 27.759 1 0.267 0.0908 13.466 0.095 0.0254 4.4680 1 0.068 0.0220 3.2670 0.015 0.0050 0.7760 0.032 0.0119 1.6444 0.020 0.0069 1.0189 0.006 0.0022 0.2898 0.679 0.2244 35.127 0.721 0.2677 37.050 0.779 0.2695 39.442 0.170 0.0792 8.4771 Group : VI 5 mg/kg/day Sex :FEMALES | ANIMAL I OVARIES | SPLEEN ( THYMUS | THYROID GLAND j UTERUS | | I(Gms) %FBW %BRAIN ](Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j 655020 655029 655034 655038 655039 655042 655054 655066 655067 655087 0.144 0.0477 7.4573 0.127 0.0454 6.9361 0.127 0.0490 7.2241 0.164 0.0560 8.0988 0.104 0.0345 5.2288 0.163 0.0480 8.3590 0.170 0.0674 8.7269 0.161 0.0523 8.2185 0.074 0.0254 3.9153 0.174 0.0553 8.5714 0.703 0.2331 36.406 0.510 0.1822 27.854 0.643 0.2482 36.576 0.555 0.1896 27.407 0.580 0.1925 29.160 0.821 0.2416 42.103 0.593 0.2350 30.441 0.548 0.1779 27.973 0.521 0.1788 27.566 0.750 0.2383 36.946 0.302 0.1001 15.640 0.321 0.1147 17.531 0.324 0.1250 18.430 0.337 0.1151 16.642 0.193 0.0641 9.7034 0.520 0.1530 26.667 0.347 0.1375 17.813 0.322 0.1045 16.437 0.310 0.1064 16.402 0.263 0.0836 12.956 0.024 0.0080 1.2429 0.014 0.0050 0.7646 0.019 0.0073 1.0808 0.020 0.0068 0.9877 0.024 0.0080 1.2066 0.023 0.0068 1.1795 0.019 0.0075 0.9754 0.021 0.0068 1.0720 0.019 0.0065 1.0053 0.019 0.0060 0.9360 0.560 0.1857 29.001 | 0.539 0.1926 29.437 0.438 0.1690 24.915 0.754 0.2576 37.235 1.067 0.3541 53.645 0.754 0.2219 38.667 1.435 0.5688 73.665 0.656 0.2129 33.486 0.615 0.2111 32.540 0.557 0.1770 27.438 Mean S.D. 0.141 0.0481 7.2736 0.033 0.0116 1.5691 0.622 0.2117 32.243 0.105 0.0296 5.2803 0.324 0.1104 16.822 0.082 0.0255 4.3252 0.020 0.0069 1.0451 0.003 0.0009 0.1436 0.738 0.2551 38.003 0.300 0.1226 14.926 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -682- 90-Day Ora; avage StudSyubinchRraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : VIII 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS ] THYROID GLAND | UTERUS | 1 (Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN | 655011 655012 655047 655055 655058 655073 655076 655078 655085 655105 0.120 0.0391 6.1287 0.165 0.0540 8.2583 0.112 0.0423 5.9103 0.156 0.0558 7.4039 0.124 0.0446 6.0725 0.166 0.0544 8.4093 0.156 0.0525 7.4004 0.116 0.0330 5.6066 0.112 0.0352 6.0377 0.108 0.0402 5.3492 0.660 0.2152 33.708 0.666 0.2179 33.333 0.580 0.2190 30.607 0.535 0.1914 25.392 0.617 0.2218 30.215 0.527 0.1726 26.697 0.655 0.2205 31.072 0.530 0.1509 25.616 0.506 0.1592 27.278 0.460 0.1711 22.784 0.364 0.1187 18.590 0.283 0.0926 14.164 0.427 0.1612 22.533 0.298 0.1066 14.143 0.249 0.0895 12.194 0.301 0.0986 15.248 0.275 0.0926 13.046 0.331 0.0942 15.998 0.422 0.1327 22.749 0.334 0.1243 16.543 0.019 0.0062 0.9704 0.031 0.0101 1.5516 1 0.019 0.0072 1.0026 0.016 0.0057 0.7594 0.017 0.0061 0.8325 0.022 0.0072 1.1145 0.022 0.0074 1.0436 0.023 0.0065 1.1116 0.025 0.0079 1.3477 0.019 0.0071 0.9411 0.801 0.2612 40.909 0.560 0.1832 28.028 0.847 0.3197 44.697 0.525 0.1878 24.917 0.613 0.2203 30.020 0.972 0.3184 49.240 0.827 0.2785 39.231 0.962 0.2738 46.496 0.948 0.2982 51.105 0.743 0.2764 36.800 Mean S.D. 0.134 0.0451 6.6577 0.024 0.0085 1.1116 0.574 0.1940 28.670 0.073 0.0282 3.6453 0.328 0.1111 16.521 0.060 0.0231 3.6987 0.021 0.0071 1.0675 0.004 0.0012 0.2351 0.780 0.2618 39.144 | 0.166 0.0493 9.1149 j Group : X 125 mg/kg/day Sex :FEMALES 1 ANIMAL 1 OVARIES 1 SPLEEN 1 THYMUS j THYROID GLAND | UTERUS | 1 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN j 655007 1 0.111 0.0392 5.7722 655023 j 0.157 0.0555 8.4409 655026 1 0.169 0.0597 8.4458 655052 j 0.152 0.0547 7.3218 655053 1 0.151 0.0494 7.1025 655063 j 0.141 0.0561 7.3745 655092 j 0.178 0.0595 8.7642 655095 j 0.121 0.0382 5.3802 655097 j 0.103 0.0349 5.5676 0.561 0.1982 29.173 0.576 0.2037 30.968 0.753 0.2660 37.631 0.624 0.2246 30.058 0.594 0.1942 27.940 0.624 0.2481 32.636 0.618 0.2064 30.428 0.646 0.2037 28.724 0.594 0.2015 32.108 0.310 0.1095 16.121 0.273 0.0966 14.677 0.222 0.0784 11.094 0.414 0.1490 19.942 0.266 0.0870 12.512 0.361 0.1435 18.881 0.388 0.1296 19.104 0..430 0.1356 19.120 0.237 0.0804 12.811 0.028 0.0099 1.4561 0.020 0.0071 1.0753 0.022 0.0078 1.0995 0.028 0.0101 1.3487 0.023 0.0075 1.0818 0.016 0.0064 0.8368 0.023 0.0077 1.1324 0.018 0.0057 0.8004 0.016 0.0054 0.8649 0.468 0.1654 24.337 0.570 0.2016 30.645 0.530 0.1872 26.487 0.821 0.2955 39.547 0.548 0.1791 25.776 0.503 0.2000 26.308 1.484 0.4957 73.067 1.262 0.3980 56.114 0.850 0.2883 45.946 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI -683- "'90-Day Oral Gava_g_e_S__tudSyubinchRroantsi_c_T_o_x_i_c_it_y ) DuPont-9478 Organ Weight Listing Female Rats Designated for Subchronic Toxicity Group : X 125 mg/kg/day Sex !FEMALES | ANIMAL [ OVARIES | SPLEEN | THYMUS | THYROID GLAND | UTERUS | | I(Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |Gms) %FBW %BRAIN j(Gms) %FBW %BRAIN | 1 655103 1 0.119 0.0404 5.7683 1 0.504 0.1713 24.430 j 0.326 0.1108 15.802 1 0.023 0.0078 1.1149 1 1.043 0.3544 50.557 1 i1 I1 Ii 1I 1 1 1I 1 Mean | 0.140 0.0488 6.9938 j 0.609 0.2118 30.410 j 0.323 0.1120 16.006 j 0.022 0.0075 1.0811 j 0.808 0.2765 39.878 I 1 S.D. 1 0.025 0.0096 1.3010 j 0.065 0.0275 3.4424 1 0.074 0.0263 3.1870 j 0.004 0.0016 0.2112 j 0.354 0.1109 16.348 j Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -684- 90-Day Oral Gavage tudSyuibnchRraotnsic Toxicity ) DuPont-9478 Organ Weight Listing Female Rats Designated for Recovery Group : II 0 mg/kg/day Sex :FEMALES 1 ANIMAL ' FBW 1 BRAIN j ADRENAL GLANDS | HEART | KIDNEYS | LIVER | 1 (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN j (Gms) %FBW %BRAIN \ 655009 655015 655019 655035 655062 655068 655072 655101 655109 317.10 288.40 347.70 322.80 344.40 329.80 340.90 405.90 309.30 1.939 0.6115 1.944 0.6741 2.218 0.6379 2.005 0.6211 2.091 0.6071 1.950 0.5913 2.148 0.6301 2.063 0.5083 2.138 0.6912 0.090 0.0284 4.6416 0.087 0.0302 4.4753 0.128 0.0368 5.7710 0.060 0.0186 2.9925 0.092 0.0267 4.3998 0.075 0.0227 3.8462 0.090 0.0264 4.1899 0.062 0.0153 3.0053 0.080 0.0259 3.7418 1.165 0.3674 60.083 1.208 0.4189 62.140 1.506 0.4331 67.899 1.503 0.4656 74.963 1.433 0.4161 68.532 1.346 0.4081 69.026 1.343 0.3940 62.523 1.428 0.3518 69.220 1.053 0.3404 49.252 2.266 0.7146 116.86 2.580 0.8946 132.72 2.890 0.8312 130.30 2.396 0.7423 119.50 3.128 0.9082 149.59 2.501 0.7583 128.26 2.620 0.7686 121.97 2.730 0.6726 132.33 2.338 0.7559 109.35 8.669 2.7338 447.09 9.943 3.4476 511.47 11.718 3.3701 528.31 9.806 3.0378 489.08 11.122 3.2294 531.90 9.951 3.0173 510.31 11.076 3.2490 515.64 11.298 2.7834 547.65 9.201 2.9748 430.36 Mean S.D. 334.03 2.055 0.6192 32.847 0.102 0.0524 0.085 0.0257 4.1182 0.020 0.0063 0.8616 1.332 0.3995 64.848 0.158 0.0404 7.4199 2.605 0.7829 126.77 10.309 3.0937 501.31 0.277 0.0795 11.614 1.040 0.2483 39.253 Group ; X 125 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW BRAIN ! j (Gms) (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 1 655010 1306.30 j 655030 455.30 1 655037 394.40 j 655049 249.70 1 655061 289.30 1 655075 432.20 1 655077 326.60 1 655084 302.10 j 655088 374.80 1.816 0.5929 2.008 0.4410 1.968 0.4990 1.863 0.7461 1.786 0.6174 1.968 0.4553 2.010 0.6154 2.012 0.6660 2.010 0.5363 0.074 0.0242 4.0749 0.071 0.0156 3.5359 0.092 0.0233 4.6748 0.062 0.0248 3.3280 0.076 0.0263 4.2553 0.089 0.0206 4.5224 0.081 0.0248 4.0299 0.075 0.0248 3.7276 0.047 0.0125 2.3383 HEART (Gms) %FBW %BRAIN 1.192 0.3892 65.639 1.472 0.3233 73.307 1.245 0.3157 63.262 0.977 0.3913 52.442 1.022 0.3533 57.223 1.491 0.3450 75.762 1.181 0.3616 58.756 1.162 0.3846 57.753 1.188 0.3170 59.104 KIDNEYS LIVER | (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN j 3.426 1.1185 188.66 3.615 0.7940 180.03 2.503 0.6346 127.18 2.027 0.8118 108.80 2.218 0.7667 124.19 2.920 0.6756 148.37 2.312 0.7079 115.02 2.425 0.8027 120.53 2.705 0.7217 134.58 11.589 3.7835 638.16 13.781 3.0268 686.30 10.562 2.6780 536.69 7.045 2.8214 378.15 8.489 2.9343 475.31 11.180 2.5868 568.09 9.701 2.9703 482.64 8.440 2.7938 419.48 10.908 2.9104 542.69 FBW - Final Body Weight Company Sanitized. Does not contain TSCA O 03 '90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity ) ) DuPont-9478 Organ Weight Listing Female Rats Designated for Recovery Group : X 125 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW BRAIN I ADRENAL GLANDS 1 1 (Gms) 1(Gms) %FBW 1 (Gms) %FBW %BRAIN 1I 655100 1 1 Mean S.D. 1358.50 11 1I 1.917 1 0.5347 1 1 l 1348.92 1 1.936 0.5704 65.818 i 0.086 0.0956 0.083 0.0232 4.3297 0.075 0.0220 3.8817 0.013 0.0045 0.6889 HEART (Gms) %FBW %BRAIN 1.409 0.3930 73.500 1.234 0.3574 63.675 0.175 0.0314 8.0787 KIDNEYS (Gms) %FBW %BRAIN 3.231 0.9013 168.54 2.738 0.7935 141.59 0.541 0.1374 28.381 LIVER 1 (Gms) %FBW %BRAIN 1 11.691 3.2611 609.86 10.339 2.9766 533.74 1.961 0.3399 96.914 Company Sanitized. Does not contain TSCA FBW - Final Body Weight O CD  |9^0^-D||[a|y||OHraml GimavBagjeSSutubdyc hinrRoantsic Toxicity DuPont-9478 Organ Weight Listing Female Rats Designated for Recovery Group : II 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 OVARIES 1 1(Gms) %FBW %BRAIN SPLEEN 1 THYMUS 1 THYROID GLAND | UTERUS | (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN j 655009 655015 655019 655035 655062 655068 655072 655101 655109 0.142 0.0448 7.3234 0.099 0.0343 5.0926 0.164 0.0472 7.3940 0.100 0.0310 4.9875 0.079 0.0229 3.7781 0.100 0.0303 5.1282 0.196 0.0575 9.1248 0.175 0.0431 8.4828 0.121 0.0391 5.6595 0.622 0.1962 32.078 0.646 0.2240 33.230 0.819 0.2355 36.925 0.648 0.2007 32.319 0.601 0.1745 28.742 0.503 0.1525 25.795 0.749 0.2197 34.870 0.631 0.1555 30.587 0.512 0.1655 23.948 0.164 0.0517 8.4580 0.204 0.0707 10.494 0.359 0.1032 16.186 0.221 0.0685 11.022 0.165 0.0479 7.8910 0.261 0.0791 13.385 0.247 0.0725 11.499 0.183 0.0451 8.8706 0.345 0.1115 16.137 0.027 0.0085 1.3925 0.013 0.0045 0.6687 0.037 0.0106 1.6682 0.025 0.0077 1.2469 0.027 0.0078 1.2912 0.029 0.0088 1.4872 0.020 0.0059 0.9311 0.028 0.0069 1.3572 0.028 0.0091 1.3096 0.721 0.2274 37.184 0.910 0.3155 46.811 1.811 0.5209 81.650 0.725 0.2246 36.160 0.784 0.2276 37.494 0.904 0.2741 46.359 0.782 0.2294 36.406 0.536 0.1321 25.982 0.798 0.2580 37.325 Mean S.D. 0.131 0.0389 6.3301 0.040 0.0105 1.8133 0.637 0.1916 30.944 0.101 0.0310 4.1837 0.239 0.0723 11.549 0.072 0.0232 3.1108 0.026 0.0078 1.2614 0.007 0.0018 0.2972 0.886 0.2677 42.819 0.364 0.1069 15.794 Group : X 125 mg/kg/day Sex :FEMALES 1 ANIMAL OVARIES SPLEEN 1 (Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN THYROID GLAND (Gms) %FBW %BRAIN UTERUS | (Gms) %FBW %BRAIN | 1 655010 1 655030 1 655037 1 655049 1 655061 1 655075 1 655077 1 655084 1 655088 0.111 0.0362 6.1123 1 0.623 Q .2034 34.306 0.085 0.0187 4.2331 1 0.591 0.1298 29.432 0.134 0.0340 6.8089 1 0.702 0.1780 35.671 0.114 0.0457 6.1192 1 0.585 0.2343 31.401 0.103 0.0356 5.7671 1 0.471 0.1628 26.372 0.092 0.0213 4.6748 1 0.511 0.1182 25.965 0.195 0.0597 9.7015 1 0.595 0.1822 29.602 0.168 0.0556 8.3499 1 0.516 0.1708 25.646 0.132 0.0352 6.5672 1 0.560 0.1494 27.861 0.249 0.0813'13.711 0.439 0.0964 21.863 0.336 0.0852 17.073 0.210 0.0841 11.272 0.157 0.0543 8.7906 0.405 0.0937 20.579 0.232 0.0710 11.542 0.171 0.0566 8.4990 0.331 0.0883 16.468 0.026 0.0085 1.4317 0.025 0.0055 1.2450 0.024 0.0061 1.2195 0.026 0.0104 1.3956 0.027 0.0093 1.5118 0.030 0.0069 1.5244 0.021 0.0064 1.0448 0.026 0.0086 1.2922 0.035 0.0093 1.7413 1.109 0.3621 61.068 0.776 0.1704 38.645 0.711 0.1803 36.128 1.329 0.5322 71.337 0.760 0.2627 42.553 0.816 0.1888 41.463 1.376 0.4213 68.458 0.706 0.2337 35.089 0.433 0.1155 21.542 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBl -687- "9_0_-_D_a_y__O_r_a_l _G_a_v_a_g_e_S_t_udSyubinchRroantsi_c_T_o_x_i_c_it_y ) DuPont-9478 Organ Weight Listing Female Rats Designated for Recovery Group : X 125 mg/kg/day Sex :FEMALES 11 ANIMAL [ OVARIES 1 SPLEEN 1 THYMUS 1 THYROID GLAND 1 UTERUS 1 1(Gins) %FBW %BRAIN j(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN 1(Gms) %FBW %BRAIN j 1 655100 1 0.100 0.0279 5.2165 | 0.770 0.2148 40.167 11 11 i1 1 Mean | 0.123 0.0370 6.3550 | 0.592 0.1744 30.642 1 S.D. 1 0.035 0.0134 1.6503 | 0.090 0.0366 4.7768 0.164 0.0457 8.5550 0.269 0.0757 13.835 0.102 0.0178 4.9551 0.020 0.0056 1.0433 0.026 0.0077 1.3450 0.004 0.0018 0.2203 1.126 0.3141 58.738 | 11 0.914 0.2781 47.502 j 0.305 0.1296 16.378 | Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -688- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity Organ Weight Listing Female Rats Designated for Satellite Evaluations (10-Day Sacrifice) Group : II 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) (Gms) 1 655141 1 655149 1 655152 1 655155 1 655159 j j Mean 1 S.D. 148.6 184.2 192.1 168.9 158.9 6.422 7.580 8.276 7.192 6.454 170.54 7.185 17.825 0.785 LIVER %FBW 4.322 4.115 4.308 4.258 4.062 4.213 0.118 Group : IV 1 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 1 655142 I 655160 1 655162 1 655164 j 655165 j! ( Mean j S.D. 163.8 135.6 159.1 178.8 164.9 7.398 6.456 6.247 8.583 7.188 160.44 7.174 15.709 0.923 4.516 4.761 3.926 4.800 4.359 4.473 0.355 1 1 1 1 FBW - Final Body weight -689- ) DuPont-9478 |; Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stu|dSyubinchRraotns_ic_T__o_x_icity ) Organ Weight Listing Female Rats Designated for Satellite Evaluations (10-Day Sacrifice) Group : VI 5 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) 1 655140 1 655145 1 655154 1 655158 j 655167 i1 j Mean j S.D. 146.6 167.3 170.8 190.3 178.7 6.848 8.360 7.907 8.156 7.798 170.74 7.814 16.129 0.582 LIVER %FBW 4.671 4.997 4.629 4.286 4.364 4.589 0.282 1 j Group : VIII 25 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW 1 (Gms) j(Gms) LIVER %FBW 1 j 1 655144 1 655148 1 655161 1 655163 1 655166 11 1 Mean j S.D. 177.0 18.157 179.5 9.610 152.3 6.735 177.5 7.720 191.6 9.596 i 1 175.58 8.364 14.315jl.243 4.608 5.354 4.422 4.349 5.008 4.748 0.424 FBW - Final Body Weight -690- DuPont-9478 30-Day Oral Gavage Sfu[dSyubinchRraotnsic Toxicity ) Organ Weight Listing Female Rats Designated for Satellite Evaluations (10-Day Sacrifice) Group : X 125 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW 1 LIVER 1 1 (Gms) 1(Gms) %FBW 555143 190.1 1 9.516 655146 170.2 j 9.894 655147 206.8 12.044 655150 185.3 10.084 655151 J160.2 j 9.130 j 1 Mean 182.52 10.134 S.D. 1 18.06 j 1.129 5.006 5.813 5.824 5.442 5.699 5.557 0.344 1 ) ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -691 - Company Sanitized. Does not contain TSCA CBI k >Q_-Da_yU__ra_l__a_v__ag__e_^_tdSyubicnhRroantsic Toxicity Organ Weight Listing Female Rats Designated for Satellite Evaluations (Final Sacrifice) Group : XI 0 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 1 655022 1 655045 1 655065 1 655074 i 655093 1 1 1 Mean 1 S.D. 316.90 336.30 378.00 345.80 252.50 325.90 46.602 10.043 3.1691 13.912 4.1368 15.652 4.1407 13.889 4.0165 8.723 3.4547 12.444 3.7836 2.922 0.4451 Group : IV 1 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW 655018 655028 655051 655057 655096 364.30 332.90 322.30 296.20 365.10 14.077 3.8641 11.003 3.3052 9.970 3.0934 11.429 3.8585 13.007 3.5626 Mean S.D. 336.16 11.897 3.5368 29.278 1.637 0.3397 1 I 1 1 FBW - Final Body Weight -692- DuPont-9478 Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage tudSyubinchRraotnsic Toxicity Organ Weight Listing Female Rats Designated for Satellite Evaluations {Final Sacrifice) Group : VJ 5 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW LIVER i j (Gms) 1(Gms) %FBW 655017 1334.50 1 11.964 3.5767 655021 321.60 1 13.230 4.1138 655050 328.50 j 13.097 3.9869 655059 286.60 i 12.290 4.2882 655064 408.40 1 12.973 3.1765 i1 1 Mean 335.92 1 12.711 3.8284 S.D. 44.576 \ 0.553 0.4490 1 i Group : VIII 25 mg/kg/day Sex -.FEMALES 1 ANIMAL i FBW (Gms) (Gms) LIVER %FBW 1 655043 j 655056 j 655060 1 655081 j 655082 !j 1 Mean 1 S.0. 305.60 311.80 393.70 417.30 405.80 366.84 53.771 10.699 3.5010 9.860 3.1623 13.407 3.4054 16.478 3.9487 17.192 4.2366 13.527 3.6508 3.301 0.4339 1 j FBW - Final Body Weight -693- ) DuPont-9478 ^90-Day Oral_U__a_v_a_g_e_S_tuIdSyubinchRraotnsic Toxicity Organ Weight Listing Female Rats Designated for Satellite Evaluations (Final Sacrifice) Group : X 125 mg/kg/day Sex :FEMALES 1 ANIMAL 1 FBW (Gms) (Gms) LIVER %FBW j 655024 1 655027 j 655046 j 655104 j 655106 11 j Mean j S.D. 364.00 346.20 418.30 372.10 296.00 359.32 44.287 12.552 3.4484 10.958 3.1652 14.617 3.4944 12.954 3.4813 12.562 4.2439 12.729 3.5666 1.305 0.4020 1 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI FBW - Final Body Weight -694- 90-Day Ural avag IidSyubinchRraotnsic Toxicity DuPont-9478 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS -695- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage IidSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANTORY NOTES tAwheicsrceiddeientneartdlmvyeiknritaletlnieotdnly.()iinncjluurdeedswahneimn ablesipnrgehseanntdeldedd.eaInd-olirfemaonrdibnuencdrothpastyhfainvdeiinngjsurmedaythbeemusseeldvetso omr ake Lesion Grading maHsepiovpsdetrooirfippiteyarirt.ahstoTeslu,hociegshidacailasssltorfciobhacsuaasntlii,ggomennseu(daeltrxaieftseodfnceoatsllocl,orfdwitbiifssef:sduusaeec,icnuovnrodilliavntegemrtaoel,ntbht)ieliiasrteimnradolir,cpeahttoce.ld;o,gAwichsecevhreearraiatpcyptesrorc,opdrreiias,ttierfi,bbuytion and LiSMdMnMneooitmoiiveerlndmnedsiierts:mnaeeriloatd:aiynttlleti:tpoimh:gsrretesiohtutenhddsexee.eeutragoecalmernelr,estooaetitohrunogonneyafetlinfxcesouhspdfpniaeyocrcncosnhttgifmaousiensninigginaecsneelateiinispofimtiirtnlchebypaseiuanseiritdntrpatemtthsonibesesctsrasinoefuirtibmee.eillsdepoy.slrbeeiguoxtentrcgieoafaesifncdlcaisdomnytnthisstpafieuodtdntewecrsnheetitdivoicaenphrl.oiiftssyos.rciboiTnlnehcsreoiedrlaeegsrseeriedodansttoepevbnreoeorbiuwtagybih.tlhyiinn Comment: icsgneordvanidetcireanestu.emuWtmihnehiwimirlieratehltlhtamhetriigvonrueiamgbdhaieolsslleorevegsfeiieocreranltsroesbiptgehrineenisgfmeinctohatrneppcrhleoeo.aglsortegssisecivavleerceihnaavrnoadlcvtseeermviseetrniects/lseoesvfioelnerisstiyobneaislno, gnthgtehaye amlsoost eGtcro.)ss observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, Neoplasm Designations **BM:: MBeanliiggnnannetonpeloaspmla,smpr,imprairmyasriytesite -696- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudtSyuibnchRraotnsic Toxicity DuPont-9478 stud y ( M Dose Group Individual Animal Listing Showing animal data for individual B : I 0 mg/kg/day Sex: Males animals Animal Ref Microscopic i Macroscopic Findings 654903 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -697- Company Sanitized. Does not contain TSCA CBI JO-Day Oral Gavage tdSyuibnchRraotnsic Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/male I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654909 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE -698- Company Sanitized. Does not contain TSCA CBI 90-uay oral avage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :flBHQ24691/male Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654910 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE -699- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud[SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref 654915 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, mild. NECROSIS, FOCAL, mild. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : THYMUS, NOSE -700- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage iSubchronic Toxicity tdy in R ats________ DuPont-9478 ^^ STUDY Dose G r o u ^ ^ l Individual Animal Listing Showing animal data for individual animals 4691/male 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654919 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654924 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654924 Continued on the next page -701 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud(SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ^ m | 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654924 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : THYMUS, THYROID GLAND, NOSE 654925 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654925 Continued on the next page .... -702- Company Sanitized. Does not contain TSCA CBI ^90^-Dmay^Omral|HGav|Sague Sbtucdhy rinoRnatisc___T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing STUDY : J m g / 2 4 6 9 1 / mShaowl eing animal data for individual animals Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654925 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PITUITARY GLAND : NOT PRESENT. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -703- Company Sanitized. Does not contain TSCA CBI m90-^D^aymOmral^GHavIagSeuSbtucdyhirnoRnatisc__T_o_x_i_c_it_y DuPont-9478 Individual Animal Listing Showing animal data for individual animals Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654927 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : THYMUS, NOSE -704- Company Sanitized. Does not contain TSCA CBI _90-Day__Oral Ga_v_a_g_e_Stu^dSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 691/male Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654928 Terminal Sacrifice Killed on Day : 93 Exposure Group : 9QDAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 654928 Continued on the next page .... -705- Company Sanitized. Does not contain TSCA CBI "90-Day Oral Gava_g_e StuIdSyuibnchRraotnsic Toxicity DuPont-9478 STUDY : Dose Group Individual Animal Listing Showing animal data for individual animals 24691/male 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654928 Continued from previous page Histopathology : PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654929 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654929 Continued on the next page .... -706- Company Sanitized. Does not contain TSCA CBI 90-Day Oral tiavag^Stu'dSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY m | j 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654929 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -707- Company Sanitized. Does not contain TSCA CBI f9B0-[Dmay|^OHra|HlGBaBvaJgJ^^tuudbyc hinxRoantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 691/male Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654936 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : TESTES : DISCOLORATION, OPAQUE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, -SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, severe. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, BILATERAL, severe. 654936 Continued on the next page -708- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage !tuidSyuibncRhraotnsic Toxicity DuPont-9478 STUDY Dose Group- Individual Animal Listing Showing animal data for individual animals J24691/male I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654936 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654939 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -709- Company Sanitized. Does not contain TSCA CBI 90-Day Oral GavageStuJdsyubinchRraotnsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :U H V / 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic Se Macroscopic Findings 654943 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : THYMUS, NOSE -710- Company Sanitized. Does not contain TSCA CBI ^^P^O^^HDfaH^OHrHaroHavHa^g^mudbychinrRoantsic Toxicity ____________________ DuPont-9478 ,,^ Individual Animal Listing Showing animal data for individual animals STUDY :U M B 0 24691/inale Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654949 Accidentally Killed Duration of dosing-days: 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL. VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : THYMUS, THYROID GLAND, NOSE -711- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage tudSyuibncRhraotnsic Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 4691/male I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654950 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. E Y E (S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, minimal. 654950 Continued on the next page .... - 712- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gav_a_g_e__StSuduybcihnroRnaitcs_T_o_x_i_c_it_y__ DuPont-9478 /'"'v Individual Animal Listing Showing animal data for individual animals STUDY : f m j 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654950 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654953 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654953 Continued on the next page .... - 713 - Company Sanitized. Does not contain TSCA CBI i9m0-DmayHO^ra^l HGapvaygSe Sutbudcyhinr oRnatsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 0 m P ^ 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654953 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. PITUITARY GLAND : CYST, minimal. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -714- Company Sanitized. Does not contain TSCA CBI n HyQl-Dllaiy|^O|[raHlGHavraig^^SSutubdcyhinrRoantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing % Showing animal data for individual animals STUDY :( B B P / 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654956 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE -715- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage tudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 691/male Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654966 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654971 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654971 Continued on the next page .... -716- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Oavage StudSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/male I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654971 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654972 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. 654972 Continued on the next page .... -717- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref Microscopic Sc Macroscopic Findings 654972 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. EY E (S ) WITH OPTIC NERVE : ADHESION, RETINAL, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654987 Terminal Sacrifice Killed on Day 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ' ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC.LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654987 Continued on the next page .... -718- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuJdSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :9 P B ^ 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654987 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -719- Company Sanitized. Does not contain TSCA CBI 30-Day Oral Gavage StudSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data.for individual animals STUDY -.flBi/24G91/male Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654992 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : THYMUS, THYROID GLAND, NOSE -720- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudayuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals ]4691/male 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654993 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy 1 Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 654993 Continued on the next page .... -721 - Company Sanitized. Does not contain TSCA CBI 90H-DHaHy OMraHl GBaHva[g^eBS^tuudbycinhrRoantsi_c_T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing _ kSJAhJLVo_/VwV iJ .An4 g.y animal data for individual animals STUDY Q m | | 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654993 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, BONE MARROW, NOSE URINARY STERNUM, 654994 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 654994 Continued on the next page .... -722- Company Sanitized. Does not contain TSCA CBI 90-Day Ora] _S_v__g_e_S_&_dyubinchRraotnsi_c_T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : q d p J 2 4 6 9 1 / m a l e Dose Group : I 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654994 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE 654997 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -723- Company Sanitized. Does not contain TSCA CBI 90-Day Oral GavageStudSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing ,,^ Showing animal data for individual animals STUDY :Q^B724691/male Dose Grouj^^iII 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654904 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654908 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : SKIN : ALOPECIA, RIGHT, SIDE. 654908 Continued on the next page .... -724- Company Sanitized. Does not contain TSCA CBI 90-D HayIOHraHl GHavIaHgeKStuJdSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref Microscopic & Macroscopic Findings 654908 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : SKIN, NOSE -725- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuJdSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 0 B 0 n 2 4 6 9 1 / m a l e Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654913 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE - 726- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study`uibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/male Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654932 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE -727- Company Sanitized. Does not contain TSCA CB! _9_0_-_D_a_y__O_r_al_Gavage StudSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing m Showing animal data for individual animals STUDY :flHHHfe4691/male Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654938 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE -728- Company Sanitized. Does not contain TSCA CBI m90-HDaiymOriaml GPav^aSgeuSbtucdyhirnoRnatis_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 0 m ^ 2 4 6 9 1 / i a a l e Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654941 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : KIDNEYS, NOSE - 729- Company Sanitized. Does not contain TSCA CBI _9_0_-D__a_y_O_r_a_l_G_a_v_a_g_e_SJtuSduybcinhrRonatisc_T_o_x_i_c_it_y__ DuPont-9478 Individual Animal Listing __ Showing animal data for individual animals STUDY :QHri^24691/male Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654945 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654946 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654946 Continued on the next page .... -730- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyiuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref Microscopic & Macroscopic Findings 654946 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654947 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654947 Continued on the next page .... -731 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : [24691/male Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654947 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S } WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654948 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654948 Continued on the next page .... - 732- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : q m ^ f 2 4 6 9 1 / m a l e Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654948 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654954 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -733- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 STUDY : Dose Group Individual Animal Listing fiVinw-ing animal data for individual animals : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654960 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathoiogy : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE - 734- Company Sanitized. Does not contain TSCA CBI Q9tK0-DayOral GavfageS^tudSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data.for individual animals STUDY :0 H H u 2 4 6 9 1 / m a l e Dose Group : III 1 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654984 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic' Abnormality Observed : THYROID GLAND, NOSE -735- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage_StuSauybcihnrRonaitcs_T_o_x_i_c_it_y__ DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/male II 1 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 654988 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654995 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654995 Continued on the next page .... -736- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/male II 1 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 654995 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE -737- Company Sanitized. Does not contain TSCA CBI 90-Day Ora_l_G__av_a_gelTtu[dSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : Q m ^ 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654907 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE -738- Company Sanitized. Does not contain TSCA CBI  90-Day Oral Gavage Stud[SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing STUDY :< P H M 24691S/mhoawleing animal data for individual animals Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654911 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE -739- Company Sanitized. Does not contain TSCA CBI 90-Day Ori ravage StudyipibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal d a t a .for individual animals STUDY : Q m J 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654916 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE -740- Company Sanitized. Does not contain TSCA CBI 90-D_a_y_O__ra_l_G__a_v_a_g_e_StutdSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : U P [ 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654917 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE -741 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage^tudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691//mmale Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654918 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654926 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654926 Continued on the next page .... - 742Company Sanitized. Does not contain TSCA CBI ^90^amyOimralmGa|^vVag|^Stuudbyc hinrRoantsi_c_T__o_x_ic_i_ty DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY .^|24691/male Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654926 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654959 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 654959 Continued on the next page .... -743- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic_T_o_x_i_ci_ty DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : Q ^ P j 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654959 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654961 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654961 Continued on the next page .... -744- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic_T_o_x_i_c_ity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 4691 /male Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654961 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654967 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654967 Continued on the next page .... -745- Company Sanitized. Does not contain TSCA CBI __9_0_-_D_a_y_O__ra_l_G__a_v_a_g_e_S_t_udByuibnchRraotnsi_c_T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ( m p 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654967 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE 654969 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -746- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing ,, Showing animal data for individual animals STUDY : ( | ^ 0 2 4 6 9 1 / m a l e Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654970 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654980 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, UNILATERAL. 654980 Continued on the next page .... -747- Company Sanitized. Does not contain TSCA CBI 90-D^ayi-O(>riai>l|iG^ ^av^a^g^eJSStuudbycihn rRoantsi_c__T_o_x_ic_i_ty DuPont-9478 STUDY can Individual Animal Listing Showing animal data for individual animals 24691/male Dose Grrooup : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654980 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, mild. DILATATION, SEMINIFEROUS TUBULES, UNILATERAL, moderate. No Microscopic Abnormality Observed : NOSE -748- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic_T__ox_i_c_it_y_________ ________ DuPont-9478 ^sS******\. Individual Animal Listing % Showing animal data for individual animals STUDY 24691/male Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654981 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654998 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : URINARY BLADDER : DILATATION, moderate 654998 Continued on the next page .... -749- Company Sanitized. Does not contain TSCA CBI 90-D ayOral GavagHe SStuudbycihnrRonaictTso_xi_c_it_y__________ _________ ___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY ^24691/male Dose Group--: V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654998 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE H istopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : URINARY BLADDER, NOSE -750- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibnchRraotns_ic_T__ox_i_c_it_y DuPont-9478 Individual Animal Listing STUDY ; | p m | 2 4 6 9 1 / mShaolweing animal data for individual animals Dose Group : V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 655005 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE H istopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE -751- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage S_tuJdSyuibncRhraotnsic T_o_x_ic_it_y DuPont-9478 STUDY : Dos Group Individual Animal Listing Showing animal data for individual animals |24691/male 'II 25 mg/kg/day Sex: Hales Animal Ref Microscopic & Macroscopic Findings 654912 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654920 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654920 Continued on the next page .... -752- Company Sanitized. Does not contain TSCA CBI ______ ISubchronic Toxicity 90-Day Oral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : y U 0 2 4 6 9 1 / m a l e Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 654920 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654922 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : NECROSIS, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. 654922 Continued on the next page .... -753- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StjudSyuibnchRraotns_ic_T__ox_i_c_it_y DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/male Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654922 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE 654923 TEKexirpl mloeisdnuarleo n GSDarcoaruyip f:i: c9e39 0 DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE H istopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. 654923 Continued on the next page .... -754- Company Sanitized. Does not contain TSCA CBI 90-DayOral Gavage StuLdSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing ^ Showing animal data for individual animals STUDY J j f l M p 24691 /male Dose Groq^^vII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654923 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654930 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654930 Continued on the next page .... -755- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic T_o_x_ic_i_ty_______ _____ ______________________________DuPont-9478 Individual Animal Listing _ Showing animal data for individual animals STUDY ( { U24691/male Dose Group ^ V I I 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654930 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654933 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -756- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref M icroscopic & M acroscopic F indings 654934 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654940 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654940 Continued on the next page -757- Company Sanitized. Does not contain TSCA CBI ~90-Damy^OmramlmGmava^g^e^S^tSuduybcinhRroantsi_c__T_o_x_ic_i_ty_ DuPont-9478 In d iv id u a l Animal L is tin g Showing anim al d a ta fo r in d iv id u a l anim als STUDY :0 H H Q 2 4 6 9 1 /m a le Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654940 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654952 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed-off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654952 Continued on the next page .... -758- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage tudSyuibncRhraotnsic To_x_ic_it_y DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/male II 25 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 654952 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654958 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654958 Continued on the next page .... -759- Company Sanitized. Does not contain TSCA CBI 90-Day avage: adSyuibncRhraotnsic Toxicity DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/male II 25 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 654958 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minima1. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE -760- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage tod,SyuibncRhraotnsic Toxicity DuPont-9478 STUDY ( M Dose Group Individual Showing animal data l 24691/male : VII 25 mg/kg/day Sex: Animal Listing for individual Males animals Animal Ref Microscopic & Macroscopic Findings 654964 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654975 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654975 Continued on the next page .... -761 - Company Sanitized. Does not contain TSCA CBI _9_0_-_D_a_y_O_ra_l_G__a_v_ag_e__SftuJdsuybinchRraotnsi_c_T__o_xi_c_it_y DuPont-9478 Individual Animal Listing ,, Showing animal data for individual animals STUDY O H p 124691/male Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654975 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : NECROSIS, FOCAL, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 654989 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654989 Continued on the next page .... -762- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Iit^uSdyubinchRraotnsi_c_T__o_xi_c_it_y DuPont-9478 Individual Animal Listing ^ __ Showing animal data for individual animals STUDY 2 4 6 9 1 / m a l e Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654989 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : ? NOSE 655001 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655001 Continued on the next page .... -763- Company Sanitized. Does not contain TSCA CBI 90-Day Ora_l_G__av_aJgeSSutbucdhyroinniRc aTtos_x_ic_i_ty_____ DuPont-9478 STUDY : Dose Group Individual Animal Listing Showing animal data for individual animals 24691/male II 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 655001 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 655006 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655006 Continued on the next page .... -764- Company Sanitized. Does not contain TSCA CBI _9_0_-_D_a_y_O__ra_l Gavage StuidSyuibnchRraotnsi_c_T_o_x_i_c_it_y DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : P H H 2 4 6 9 1 / m a l e Dose Group : VII 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 655006 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CYST, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE -765- Company Sanitized. Does not contain TSCA CBI c DuPont-9478 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654906 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX,. E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654914 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL, MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654914 Continued on the next page .... -766- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibncRhraotns_ic_T__o_xi_c_it_y DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654914 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR, minimal, KIDNEYS : HYPERTROPHY, TUBULAR, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal. JEJUNUM : NOT PRESENT. ILEUM .: NOT PRESENT. CECUM : NOT PRESENT. RECTUM : NOT PRESENT. MESENTERIC LYMPH NODE : NOT PRESENT. THYROID GLAND : ALTERATION, COLLOID, mild. 654914 Continued on the next page .... -767- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : { m p 2 4 6 9 1 / m a l e Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654914 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, PANCREAS, COLON, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654921 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654921 Continued on the next page .. -768 - Company Sanitized. Does not contain TSCA CBI 90-Day Ora: ravage StudyuibncRhraotns_ic_T__o_xi_c_it_y DuPont-9478 STUDY Dose Group Individual Animal Listing . Showing animal data for individual animals :xp4691/male 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654921 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. NECROSIS, FOCAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW -769- Company Sanitized. Does not contain TSCA CBI 90-Diamy Omrail^GKavajgSeu"SbtucdyhirnoRmatsc__T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data .for individual animals Animal Ref Microscopic & Macroscopic Findings 654931 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654937 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654937 Continued on the next page ... -770- Company Sanitized. Does not contain TSCA CBI 90-Day Oral avage stud,SyuibnchRraotns_ic_T_o_x_icity DuPont-9478 M Animal Ref Individual Aninjal Listing Showing animal data for individual animals 24691/male X 125 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 654937 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654942 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERPLASIA, BILE DUCT, minimal. NECROSIS, FOCAL, minimal. 654942 Continued on the next page .... -771- Company Sanitized. Does not contain TSCA CBI 90-Day Ora avage StudSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : Q m j 2 4 6 9 1 / m a l e Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654942 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE 654951 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. 654951 Continued on the next page .... - 772- Company Sanitized. Does not contain TSCA CBI 90-Da_y_O_r_a_l_G_a_v_a_geSSubtucdhyroinnicRTatosxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654951 Continued from previous page Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR; mild. NECROSIS, FOCAL, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW - 773Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic T_o_x_ic_ity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 4691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654955 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, RIGHT, severe. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYDRONEPHROSIS, UNILATERAL, minimal. HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. 654955 Continued on the next page .... - 774Company Sanitized. Does not contain TSCA CBI f9l0^-DmayiOmralmGanvSague Sbtucdhy rinoRiaitis_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : C B 24591/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654955 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN,.SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654957 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654957 Continued on the next page .... -775- Company Sanitized. Does not contain TSCA CBI P90^-D^a^y^O^rfal^GHavFagjSe SutubdcyhinroRnatis_c_T_o_x_i_c_it_y____________ DuPont-9478 Individual Animal Listing m Showing animal data for individual animals STUDY |^K24691/male Dose Group ^ r X 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654957 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : THYMUS, NOSE 654962 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE -776- Company Sanitized. Does not contain TSCA CBI m90-mDaHy O^ ^ra^l G^ a^vVagje^SutubdcyhinrRoantsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 654965 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : E Y E (S) WITH OPTIC NERVE : MISSING, RIGHT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KHEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. NECROSIS, FOCAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. 654965 Continued on the next page -777- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyluibncRhraotnsic Toxicity DuPont-9478 ./""N Individual Animal Listing Showing animal data for individual animals STUDY {fl|Mrt24691/male Dose Goxm^^TlX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654965 Continued from previous page Histopathology : E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 654973 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654973 Continued on the next page .... -778- Company Sanitized. Does not contain TSCA CBI 90-Pay Oral Gavage StudSyuibncRhraotns_ic_T__ox_i_c_it_y DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals [24691/male : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654973 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYMUS -779- Company Sanitized. Does not contain TSCA CBI H90^-D^aHy O^ r^aHl GHavHagje^Sutubdyc hinrRoantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654974 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE,- PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYDRONEPHROSIS, BILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : THYMUS, NOSE -780- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing oSihJ .ou ww.iL in.igy caunxi-lxmuaclij. du aautcat lfuoxr i.ndividual animals STUDY : ( B H f 2 4 6 9 1 / m a l e Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654976 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : THYMUS -781Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic _T_o_x_ic_i_ty______ ____________________ __________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : M 2 4 6 9 1 /male Dose Group ^ x X 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654977 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : KIDNEYS : CALCULUS\CALCULI, RIGHT. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E {S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : HYPERPLASIA, TRANSITIONAL CELL, minimal. HYDRONEPHROSIS, UNILATERAL, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal 654977 Continued on the next page .... - 782 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : | m p 2 4 6 9 1 / m a l e Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654977 Continued from previous page Histopathology : No Microscopic Abnormality Observed : THYMUS, NOSE 654978 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 654978 Continued on the next page .... -783 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudjSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 554978 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, THYMUS, NOSE 654979 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. KIDNEYS : PIGMENT, TUBULAR, minimal. HYPERTROPHY, TUBULAR, minimal. 654979 Continued on the next page -784- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudkSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : M B } 2 4 6 9 1 / m a l e Dose G r o u^^^IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654979 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 654982 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 654982 Continued on the next page .... -785 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing ^^ QShl i UoWwiJ .nU gy Caa-nXJLiJ.imLLaC2.lJL Ud.CaLt.U CaI Xf.VoJrX Xi. ndividual animals STUDY : | J B W 2 4 6 9 1 / m a l e Dose Grou^^^IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654982 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654983 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, UNILATERAL. EPIDIDYMIDES : SMALL, UNILATERAL. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 654983 Continued on the next page -786- Company Sanitized. Does not contain TSCA CBI P90H-D^aymOmral ^GapvIaSgeuSbtucdyhirnoRnatis_c__T_o_x_ic_i_ty________________________________________________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :Mfl|Pf24691/male Dose Group :: IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654983 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, moderate. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL, severe. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -787' Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stu(JdjyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :i 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654985 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CYST, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : ODONTODYSPLASIA, moderate. INFLAMMATION, SUBACUTE/CHRONIC, mild. No Microscopic Abnormality Observed : THYMUS -788- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudISyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing ^ Sihi uoww-iL ni igy cauni.imal data for individual animals STUDY :|J^(P24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654986 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. 654986 Continued on the next page - 789- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654986 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 654990 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654990 Continued on the next page -790- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage^tuIdSyubinchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing ,,_ Showing animal data for individual animals STUDY :Q H B 2 4 6 9 1 / m a l e Dose Grouj^^lX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654990 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : THYMUS, NOSE 654991 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654991 Continued on the next page .... -791- Company Sanitized. Does not contain TSCA CBI 90-Day Ora] ravage iitjusduybicnhRroantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing _ Showing animal data for individual animals STUDY : H j r t 24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654991 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : THYMUS, NOSE 654996 Terminal Sacrifice Killed on Day : 93 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 654996 Continued on the next page .... -792- Company Sanitized. Does not contain TSCA C8I 90-Day Oral Gavage tudSyuibnchRraotnsic Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual 24691/male : IX 125 mg/kg/day Sex: Males animals Animal Ref Microscopic & Macroscopic Findings 654996 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION, AMELOBLASTS, mild. 4 No Microscopic Abnormality Observed : ' LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E {S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW -793- Company Sanitized. Does notcontainTSCACBI j9^0^-P^a^y^OHraHl GHavHagpeSSutubdyc hinrRoantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :|jB^Br24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 655003 Terminal Sacrifice Killed on Day : 93 Exposure'Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 655003 Continued on the next page .. .. - 794Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :|jppf24691/male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 655003 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -795- Company Sanitized. Does not contain TSCA CBI P90m-Damy Omral^G^ajvSague Sbtucdhy irnoRiautsc__T__o_x_ic_i_ty_____ __________ ________________________________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY BP'24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655009 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER NECROSIS, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS -796- Company Sanitized. Does not contain TSCA CBI 20-Day Oral Gavage Stu[dSyubinchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :JPHB3|24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655015 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655016 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : HEART : LARGE. 655016 Continued on the next page .... -797- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :flHB^24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655016 Continued from previous page Gross Pathology : Wo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -798- Company Sanitized. Does not contain TSCA CBI 90-Day_O_r_a_l_G__a_vage StuidSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655019 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : UTERUS : DILATATION. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. UTERUS : DILATATION, mild. -799- Company Sanitized. Does not contain TSCA CBI 90-Day O ral GavagMe SlStuudbycihnrRoartns_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing STUDY :H H i i 24691/Sheomwing animal data, for individual animals Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655022 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655025 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655025 Continued on the next page -800- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StujSduybicnhRroatnsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing shnwing animal data for individual animals STUDY : Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655025 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -801- Company Sanitized. Does not contain TSCA CBI __9_0_-Day Oral Gavage StuJSdyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing ^ . Showing animal data for individual animals STUDY :(JBBQ24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655031 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : HYDRONEPHROSIS, BILATERAL, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. 655031 Continued on the next page .... -802- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :g p P 0 2 4(6249619/1/ffeemm Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655031 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655032 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655032 Continued on the next page .... - 803 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 4691/fem : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655032 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655035 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655035 Continued on the next page .... -804- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage.StuJdSyubinchRraotnsic Toxicity DuPont-9478 a" Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655035 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS 655036 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655036 Continued on the next page .... -805- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing STUI>Y :l P K # 24691S/fheomwing animal data for individual animals Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655036 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, : E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655045 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655045 Continued on the next page .. .. -806- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxic_i_ty_____________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :0 H | M 2 4 6 9 1 / f e m Dose Group T i l 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655045 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655062 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology PITUITARY GLAND : LARGE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655062 Continued on the next page .... - 807- Company Sanitized. Does not contain TSCA CBI ^90m-DmaymOr^al^GHavmagSe Sutbudcyhinr oRantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 4 V B y 2 4 6 9 1 / f e m Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655062 Continued from previous page Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : PITUITARY GLAND 655065 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : - No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE - 808 - Company Sanitized. Does not contain TSCA CBI "90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :|Hjjjjjj^24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655068 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : LIVER 655071 Accidentally Killed Duration of dosing-days: 19 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : STOMACH : FLUID, RED. 655071 Continued on the next page .... -809- Company Sanitized. Does not contain TSCA CBI J90^-Dmay^O^rHal GmavSague Sbtucdhy irnoRnatis_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : { P m ^ 2 4 691/fern Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655071 Continued from previous page Gross Pathology : ESOPHAGUS : PERFORATION, LARGE CLOTTING IN AREA OF PUNCTURE. SKIN : STAIN, RED, NOSE. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, severe. LACERATION. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, mild. 655071 Continued on the next page .... -810- Company Sanitized. Does not contain TSCA CBI ubchronic Toxicity 90-Day Oral Gavage Study in Rats ________ ______________________ ___ ______ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY J24691/'fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655071 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655072 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy ^ Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655072 Continued on the next page .. .. -811- Company Sanitized. Does not contain TSCA CBI /***% /'"'N ! 90-_D_a_y_O_r_a_l_G_a_v_a_g_e__SItuSduybcinhrRoantisc Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655072 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS 655074 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -812- Company Sanitized. Does not contain TSCA CBI [Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ( P ^ ^ 2 4 6 9 1 / f e m Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655079 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, . FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. 655079 Continued on the next page .... /#***"V -813- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study ibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 0 *^ STUDY : Dose Group Individual Animal Listing Showing animal data for individual animals 24691/fem II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655079 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655083 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655083 Continued on the next page .... -814- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-Day Oral Gavage Study in Rats___________ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 4691/fem : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655083 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655093 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655093 Continued on the next page .... -815- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-1 ay )ral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655093 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655098 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 655098 Continued on the next page .... -816- Company Sanitized. Does not contain TSCA CBI ubchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :^ m | 2 4 6 9 1 / f e m Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655098 Continued from previous page Histopathology : HEART : CARDIOMYOPATHY, minimal. URINARY BLADDER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : LIVER, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655099 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655099 Continued on the next page .. .. -817- Company Sanitized. Does not contain TSCA CBI 90-Day Orai Gavage Study in Rats__T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655099 Continued from previous page Gross Pathology : Mo Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E {S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -818- Company Sanitized. Does not contain TSCA CBI ubchronic Toxicity 90-Day Oral G avage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : | p B W 2 4 6 9 1 / f e m Dose Group : il 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655101 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : LIVER -819- Company Sanitized. Does not contain TSCA CBI  90-D ay O ral G avage S^tucdyh irnoRnatis_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings S55107 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE - 820- Company Sanitized. Does not contain TSCA CBI _________ ______________ Subchronic Toxicity 90-D ay Oral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 124691/fem Dose Group : II 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655109 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERPLASIA, BILE DUCT, minimal. No Microscopic Abnormality Observed : KIDNEYS -821 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY $ 1 ) 2 4 6 9i/fern Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655013 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655018 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655018 Continued on the next page - 822- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudISyuibncRhraotnsic Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/fem : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655018 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655028 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE - 823- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 0-Day Oral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY m ^ 4 6 9 1/fem Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655033 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655040 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655040 Continued on the next page .... - 824- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-D ay Oral Gavage Study in Rats___________ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/fem IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655040 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655041 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655041 Continued on the next page .... -825- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :| p ( P 5 2 4 6 9 1 / f e m Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655041 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655044 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS - 826- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud'SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655051 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655057 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655057 Continued on the next page .. .. -827Company Sanitized. Does not contain TSCA CBI ubchronic Toxicity ^O-Day Oral Gavage Study in Rats___________ DuPont-9478 STUDY Dose Individual Animal Listing Showing animal data for individual animals 24691/fem V 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655057 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655086 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS - 828- Company Sanitized. Does not contain TSCA CBI 90-Day Orai ____ Subchronic Toxicity avage Study in Rats DuPont-9478 Individual Animal Listing ^ S h o w i n g animal data for individual animals STUDY :|M|j24691/fem Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655089 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed KIDNEYS 655090 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655090 Continued on the next page .... -829- Company Sanitized. Does not contain TSCA C8I Subchronic Toxicity 90-D ay Oral Gavage Study in Rats___________ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ( m p 2 4 6 9 1 / e m Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655090 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655091 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655091 Continued on the next page .... -830Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : IV 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655091 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. 655096 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -831 Company Sanitized. Does not contain TSCA CBI ubchronic Toxicity 0-Day Oral Gavage Study in Rats___________ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals :v|24691/fem 1 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655108 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS -832- Company Sanitized. Does not contain TSCA CBI mIQ-DmaymOrmal G^ava>geuSbtucdyh irnoRnatis_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :Q H B } 24691/em Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655017 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATED Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655020 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655020 Continued on the next page ... . - 833 Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ^ppf^24691/fem Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655020 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY' BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655021 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS,`HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -834Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibncRhraotsnic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : | m p 2 4 6 9 1 / f e m Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655029 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655034 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655034 Continued on the next page -835Company Sanitized. Does not contain TSCA CBI 90-Day Orai Subchronic Toxicity avage Study in Rats DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : Q H I 0 24691/fem Dos I 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655034 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655038 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655038 Continued on the next page .... - 836- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-Day Oral Gavag^Study in Rats DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655038 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655039 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS -837 - Company Sanitized. Does not contain TSCA CBI LSubchronic Toxicity ~90-Day Oral Gavage Study in Rats DuPont-9478 Animal M Ref Individual Animal Listing Showing animal data for individual 24691/fem I 5 mg/kg/day Sex: Females Microscopic & Macroscopic Findings animals 655042 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655050 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655050 Continued on the next page .... -838 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage IidSyubinchRraotnsic Toxicity DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/fem I 5 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 655050 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY-BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655054 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. - 839Company Sanitized. Does not contain TSCA CBI  DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY C B B 2 4 6 9 1 /fe m Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655059 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655064 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655064 Continued on the next page -840- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud[SyuibnchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : Q m | 2 4 6 9 1 / f e m Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655064 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655066 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS -841- Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-Day Or; ravage Study in Rats ____ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual 24691/fem : VI 5 mg/kg/day Sex: Females animals Animal Ref Microscopic & Macroscopic Findings 655067 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655087 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655087 Continued on the next page .... -842- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibncRhraotsnic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655087 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. - 843 Company Sanitized. Does not contain TSCA CBI Subchronic Toxicity 90-Day Oral Gavage Study in Rats DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : J U g | 2 4 6 9 1 / f e m Dose Group : VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655011 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655012 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655012 Continued on the next page .... - 844Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud,SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : (ta|^24691/fem Dose Group : VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655012 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655043 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -845- Company Sanitized. Does not contain TSCA CBI I9H0-DHayHO^rmal Gi^a^vHagS^tuubdyc hinrRoantsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : j B M j ^ 2 4691/fem Dose Grou^^TviII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655047 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655055 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655055 Continued on the next page .... -846- Company Sanitized. Does not contain TSCA CBI 0 ***\ ; 90-Day Or ravage StudyluibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals s t u d y :W l 24691/fem Dose Group : VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655055 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY' GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655056 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -847Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :fHMlj|24691/em Dose Grcfflj^^vTII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655058 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S } WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655060 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655060 Continued on the next page .... -848Company Sanitized. Does not contain TSCA CBI DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : 24691/fem Dose Group : VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655060 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND,- PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY- BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655073 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS -849Company Sanitized. Does not contain TSCA CBI 90-Day Oral Ga_v_a_g_e_T_tudSyuibncRhraotnsic Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals ,24691/fem VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655076 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655078 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655078 Continued on the next .page .... -850- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stu^dSyuibnchRroantsic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : { ^ M j 2 4 6 9 1 / f e m Dose Grou^^TviII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655078 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655081 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES,. UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE -851 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage_Stu|dSyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing ,, m Showing animal data for individual animals STUDY : ( j H p 2 4 6 9 1 / f e m Dose Grouj^^vIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655082 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655085 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655085 Continued on the next page .... -852- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref Microscopic & Macroscopic Findings 655085 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : KIDNEYS 655105 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655105 Continued on the next page .... -853- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuLdSyuibnchRiaotns_ic_T__o_x_ic_i_ty_ Individual Animal Listing ^ Showing animal data for individual animals STUDY 24691/fem Dose Groui^^vl 11 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655105 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS DuPont-9478 -854- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study-uibncRhraotns_ic__T_o_x_ic_i_ty_________________________________________________DuPont-9478 Individual Animal Listing ^ Showing animal data for individual animals STUDY : Q m p 2 4 6 9 1 / f e m Dose G r o u ^ ^ T x 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655007 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : HYPERPLASIA, BILE DUCT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : CARDIOMYOPATHY, minimal. 655007 Continued on the next page .... -855- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : | H m | 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655007 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655010 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655010 Continued on the next page .... -856- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuJdSyuibnchRraotnsic Toxicity DuPont-9478 / '"'"N Individual Animal Listing ^_ Showing animal data for individual animals STUDY n 4 6 9 1 / f e n Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655010 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, mild. No Microscopic Abnormality Observed : LIVER 655023 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 655023 Continued on the next page .... -857- Company Sanitized. Does not contain TSCA CBI Q H [ H ^ |^ |H n S u b c h r o n i c Toxicity 9^Pa^OralGavag^tudy in Rats______________________________ _____________________DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/fern 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655023 Continued from previous page Histopathology : KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655024 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655024 Continued on the next page .... - 858 - Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study in Rats DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY C BHR24691/feiti Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655024 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655026 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. 655026 Continued on the next page .. .. -859- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyuinbcRhraotnsic To_x_i_c_it_y DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655026 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655027 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655027 Continued on the next page .... - 860- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudiSyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals study :( m K n 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655027 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655030 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : ANGIECTASIS, minimal. 655030 Continued on the next page .... -861 - Company Sanitized. Does not contain TSCA CBI P90^-DJ |aHy Of lrHal GHaKvag)eSSutubdcyhinr Ro antsi_c__T_o_x_ic_it_y____ ____________________________________________DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :t t M Pp24691/fem Dose Group zlL 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655030 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, mild. HYDRONEPHROSIS, BILATERAL, minimal. 655037 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS -862- Company Sanitized. Does not contain TSCA CBI _9_0_-_D_a_y__O_r_a_l_G_a_v_a_g_e_S_tu/SduybicnhRroatnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :f l B B r | 24691/fem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655046 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655049 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON., RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655049 Continued on the next page .... - 863- Company Sanitized. Does not contain TSCA CBI "9_0_-Day Oral Gavag_e_S_tIuSduybicnhRroantsic T_o_x_i_c_it_y_ DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual 124691/fem : X 125 mg/kg/day Sex: Females animals Animal Ref Microscopic & Macroscopic Findings 655049 Continued from previous page Gross Pathology : Mo Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA, BILE DUCT, minimal. No Microscopic Abnormality Observed : KIDNEYS 655052 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655052 Continued on the next page .... -864- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Study in Rats Toxicity DuPont-9478 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 24691/fem X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655052 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. ADRENAL GLANDS : MINERALIZATION, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -865- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stud[SyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing _ oSihiuowwjiLniigy cauniii imuaa lx udaa utaa lfuoir ji. undividual animals STUDY : ^ U ^ j 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655053 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. No Microscopic Abnormality Observed : . KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 655053 Continued on the next page .... - 866- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudISyuibncRhraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing aaxnxixxmuacul. udaa tu aa jf.uoxr xixni dividual animals 24691/fem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655053 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655061 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 655061 Continued on the next page .... -867- Company Sanitized. Does not contain TSCA CBI ^ 9l0^-DmaymOrmal G^avSagi ei bStcudhyrinoRnatisc Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 24691/fem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655061 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655063 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. SKELETAL MUSCLE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 655063 Continued on the next page .... - 868- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudyubinchRraotnsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : ^ H | K 4 6 9 1 / f e m Dose Group :"X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655063 Continued from previous page Histopathology EY E {S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. FOLD/ROSETTE, RETINAL, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655075 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655075 Continued on the next page ... -869- Company Sanitized. Does not contain TSCA CBI 9T)ay Oral Gavage StujdSyubinchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing __ Showing animal data for individual animals STUDY : Q ^ P j 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655075 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655077 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655077 Continued on the next page .... -870- Company Sanitized. Does not contain TSCA CBI m90-mDaymOrmal G^ajvSague bStucdhy rinoRnatisc Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY 0 ^ P ] 2 4 6 9 1 / e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655077 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ANGIECTASIS, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655084 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655084 Continued on the next page .... -871- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibncRhraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY |24691/fem Dose Group" ~X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655084 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EY E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655088 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655088 Continued on the next page .... -872- Company Sanitized. Does not contain TSCA CBI T>0-Day Oral Gavage StuIdSyubinchRraotns_ic__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :J U | | p 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655088 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655092 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655092 Continued on the next page .... -873- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic__T_o_x_ic_i_ty DuPont-9478 Individual Animal Listing ^ Showing animal data for individual animals STUDY :\JUjj24691/fem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655092 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MAMMARY GLAND (FEMALE) : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE - 874- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StJuSduybinchRraotnsic Toxicity DuPont-9478 M Animal Ref Individual Animal Listing Showing animal data for individual animals 24691/fem 125 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 655095 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 655095 Continued on the next page .... - 875- Company Sanitized. Does not contain TSCA CBI P90i-mDamy O^rHalG^a^vHagS^Sutubdcyhinr oRantsic Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY :(|P|p2244669911//ffeem Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655095 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655097 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655097 Continued on the next page .... -876- Company Sanitized. Does not contain TSCA CBI t90-Day Oral Gavage Study in Rats Toxicity DuPont-9478 Individual Animal Listing Showing animal data for individual animals STUDY : j m p j 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655097 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655100 Terminal Sacrifice Killed on Day : 183 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND,'PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655100 Continued on the next page .... -877- Company Sanitized. Does not contain TSCA CBI H90-HDa^y^O^ra^l lGIapvajg^euSbtucdyhirnoRnatis_c_T__o_x_ic_i_ty________________________________________________ DuPont-9478 Individual Animal Listing ,, Showing animal data for individual animals STUDY ^ 2 4 6 9 1 / f e m Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655100 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, mild. No Microscopic Abnormality Observed : LIVER 655103 Terminal Sacrifice Killed on Day : 94 Exposure Group : 90DAY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERPLASIA, BILE DUCT, minimal 655103 Continued on the next page .... - 878 - Company Sanitized. Does not contain TSCA CBI I'0H-DHayHOrHal HGavvaJgSe Sutbudcyhinr oRnatsi_c__T_o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing Showing animal data for individual animals Animal Ref Microscopic & Macroscopic Findings 655103 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. MAMMARY GLAND (FEMALE) : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 655104 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 655104 Continued on the next page .... -879- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StudSyuibnchRraotns_ic_T__o_x_ic_i_ty_ DuPont-9478 Individual Animal Listing ^ Showing animal data for individual animals study :C f l H P 24691/em Dose Group : X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655104 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 655106 Terminal Sacrifice Killed on Day : 175 Exposure Group : SATEL Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE - 880- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage ItdSyuibnchRraotns_ie_T__o_x_ic_i_ty DuPont-9478 APPENDIX O INDIVLIIDSUTIANLGAINNDIMIVAILDMUAICLRAONSICMOAPLICS OABFSFEERCVTEADTIONS - 881 - Company Sanitized. Does not contain TSCA CBI Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage Stu}dSyuibnchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (NUMERIC) Males LESIONS TREATMENT 0 11 mg/kg| mg/kg I 1 III 1 5 1 25 mg/kg| mg/kg V 1 VII 1 125 mg/kg IX DIGESTIVE SYSTEM 1 I I LIVER 1 ) NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. 11 11 1 1 (20) (10) (10) GO) (20) 1 654909 654917 654922 654921 654915 654923 654942 654927 654940 654951 654958 654957 654975 654965 654973 654974 654976 654977 654990 654903 654908 654907 654922 654921 654909 654913 654911 654923 654951 654910 654932 654916 654930 654955 654915 654938 654917 654940 654957 654924 654941 654959 654952 654965 654925 654946 654961 654958 654973 654927 654947 654967 654989 654974 654928 654960 654980 655001 654976 654929 654995 654998 655006 654977 654936 654949 654950 655005 1 1 1 654978 654979 654983 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -882- DuPont-9478 Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage 'udSyuibnchRraotnsic Toxicity Microscopic observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS 111 LESION INCIDENCE (NUMERIC) 1 Males TREATMENT 0 mg/kg I 1 mg/kg III 5 1 25 mg/kg| mg/kg v 1 VII 1 125 mg/kg IX DIGESTIVE SYSTEM LIVER INFLAMMATION, SUBACUTE/CHRONIC. 1 ! | HYPERTROPHY, HEPATOCELLULAR. 1 HYPERPLASIA, BILE DUCT. 1 1 I !1! 1 ! 1 1!1 11 (20) (10) (10) 1 (10) (20) 1 654953 6549851 654956 654990) 654972 654991 654987 654996 654992 655003 654993 654994 654914 654921 654951 1654955 654965 654979 654983 654986 654996 655003 654915 654942 654927 654973 654943 654974 654949 654977 654992| 654978 1 654990 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -883- ) DuPont-9478 90-Day Oral Gavage udSyubinchRraotnsic Toxicity 1 11 ! ii LESIONS Microscopic Observations in Male Rats Listing individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (NUMERIC) 11 Males TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM LIVER (20) (10) (10) GO) (20) FATTY CHANGE, MEDIAN CLEFT. 1 1 | FATTY CHANGE, CENTRILOBULAR. 1 654909 654984 654907 654958 654951 654910 654995 654911 654929 654972 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -884- 90-Day Oral Gavage SPtu^dSyubinchRraotnsic Toxicity > Microscopic Observations in Male Rats Listing individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 LESIONS DIGESTIVE SYSTEM TREATMENT LESION INCIDENCE (NUMERIC) 1 ------------ 1 Males 0 mg/kg I 1 mg/kg III 5 mg/kg V 25 1 125 mg/kgj mg/kg VII I IX 1 PANCREAS GO) NO ABNORMALITY DETECTED 1 1 1 | ATROPHY. I 1 654903 654925 654929 654936 654950 654972 654987 654993 654928 654953 I Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654955 654965 654979 654983 654986 654996 655003 654921 654951 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBl -885- 90-Day Oral Gavage StudSyubinchRraotnsi_c_T__o_x_ic_i_ty LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -886- 90-Day Oral Gavage StudSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 1 LESIONS 1 1 1 1 1 | DIGESTIVE SYSTEM 1 __ ____ TREATMENT . .. _ .... _ LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX 1 STOMACH 1 | NO ABNORMALITY DETECTED l 1 i l l l l l (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 (10) 654914 654921 654951 654955 654965 654979 654983 654986 6549961 655003] 111 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -887- t 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity 1 LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (NUMERIC) 1I 1 Males TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI - 888- I vO-Day Oral Gav age StHudSyubinchRraotnsic Toxicity 1 11 1 1 ] LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM JEJUNUM (10) NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 I 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 1 (9) 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -889- 90-Day Oral Gavage tudSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED U0> 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -890- 90-Day Oral Gavage StujSduybicnhRroatnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS DIGESTIVE SYSTEM 1 LESION INCIDENCE (NUMERIC) 11 1 Males TREATMENT 10 1 mg/kg 1I 1 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX 1 | CECUM NO ABNORMALITY DETECTED (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -891- 90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (NUMERIC) Males LESIONS | TREATMENT 1 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM COLON (10) 1 1 1 (10) NO ABNORMALITY DETECTED 1 ! I1 1 1 1 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -892- "90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity ) LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) .. . Males 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX DIGESTIVE SYSTEM RECTUM (10) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -893- "9_0_-_D_a_y__O_r_al__G_avage StuIdSyubinchRraotnsi_c_T__o_x_ic_i_ty > Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 ! 1 i LESIONS 1 1 1 1 I 1 DIGESTIVE SYSTEM . TREATMENT LESION INCIDENCE {NUMERIC) Males 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX SALIVARY GLANDS (10) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 1 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -894- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StuIdSyubinchRraotnsi_c_T__o_x_ic_i_ty_ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX URINARY SYSTEM !1 1 KIDNEYS NO ABNORMALITY DETECTED CHRONIC PROGRESSIVE NEPHROPATHY. i 1 1 1 (20) (10) (10) (10) (20) 654903 654932 654907 654922 654942 654909 654938 654967 654973 654910 654941 655005 6549781 654925 654960 1 654929 654936 ; 1 654956 654987 654994 654915 654908 654911 654923 654914 654924 654913 654916 654930 654921 654927 654946 654917 654958 654951 654928 654947 654959 654989 654955 654943 654984 654961 654957 654949 654995 654980 654965 654950 654998 654974 654953 654976 654972 654979 654992 654986 654993 654990 654991 1 654996 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -895- ) DuPont-9478 90-Day Oral GavageStuIdSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS URINARY SYSTEM KIDNEYS PIGMENT, TUBULAR. HYPERTROPHY, TUBULAR. HYPERPLASIA, TRANSITIONAL CELL. HYDRONEPHROSIS, UNILATERAL. HYDRONEPHROSIS, BILATERAL. CYST. | TREATMENT 1 1 1 LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX 1 | 1 1 j (20) 1 1 (10) (10) (10) (20) 654979 654923 654914 654930 654921 654940 654951 654952 654955 654958 654965 654975 654979 654989 654983 655001 654986 655006 654996 655003 654977 654955 654977 654974 655006 654985 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -896- "90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS URINARY SYSTEM 1 LESION INCIDENCE (NUMERIC) t1 1 Males | TREATMENT | 0 1 I mg/kg 1X 1- 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX URINARY BLADDER (10) (1) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 11 654998 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -897- 90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS RESPIRATORY SYSTEM LESION INCIDENCE (NUMERIC) Males | TREATMENT J 0 1 1 mg/kg 1 1I 1 .1 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX LUNGS (10) NO ABNORMALITY DETECTED 1 1 1 1 | INFLAMMATION, SUBACUTE/CHRONIC. 1 S54903 654925 654928 654929 654936 654950 654972 654987 654993) 654953j 1 11t Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654986 654996 655003 654983 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -898- Gavage StudSyuibnchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -899- 90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS RESPIRATORY SYSTEM TREATMENT LESION INCIDENCE (NUMERIC) Males 0 mg/kg I 1 mg/kg III 5 mg/kg V 25 1 125 mg/kg1 mg/kg VII 1 IX 1 PHARYNX /LARYNX (10) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -900- Company Sanitized. Does not contain TSCA CBI '90-Day Oral Gavage StudsyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (NUMERIC) Males LESIONS TREATMENT 0 11 15 mg/kg| mg/kg| mg/kg 1 1 III 1 V 11 25 1 125 mg/kg1 mg/kg VII 1 IX 1 RESPIRATORY SYSTEM NOSE - NO ABNORMALITY DETECTED 1 S ODONTODYSPLASIA. INFLAMMATION, SUBACUTE/CHRONIC. 1 (20) 1 1 1 1 1 GO) 1 1 (10) 1 1 1 (10) (20) 654903] 654908 654907 654922 654914 654909 654913 654911 654923 654942 654910 654932 654916 654930 654955 654915 654938 654917 654940 654957 654924 654941 654959 654952 654974 654925 654946 654961 654958 654977 654927 654947 654967 654975 654978 654928 654960 654980 654989 654979 654929 654984 654998 655001 654983 654936 654995 655005 655006 654990 654943 654991 654949 655003 654950 654953 654956 654972 654987 654992 654993 ! 654994 i 1 1 654985 654985 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -901- ) DuPont-9478 fSubchronic Toxicity 90-Day Oral Gavage Study in Rats Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 11 1 1 LESIONS 1 1 11 i 1 RESPIRATORY SYSTEM 1 1 1 NOSE Il 1 DEGENERATION, AMELOBLASTS. 1 1 1 1 1 i 1 TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 1 25 125 mg/kg mg/kg mg/kgj mg/kg mg/kg I III v VII IX (20) (10) (10) (10) (20) 654921 654951 654965 654973 654976 654986 654996 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -902- "90-Day Oral Gavage StupdSyuibnchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS _________ TREATMENT 1 LESION INCIDENCE (NUMERIC) 1 Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX CARDIOVASCULAR SYSTEM HEART (10) NO ABNORMALITY DETECTED | CARDIOMYOPATHY. i 1 1 1 1 654903 654925 654929 654972 654993 654928 654936 654950 654953 t 654987 1 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654965 654986 655003 654951 654955 654979 654983 654996 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -903- 50-Day Oral Gavage_S_tu|dSyubinchRroantsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (NUMERIC) 1 1 Males 1 LESIONS 1 1 I 1_ ____ __________________________ ____ 1 j CARDIOVASCULAR SYSTEM 1 1 | AORTA |1 | NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 1 1 1 __ TREATMENT | 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX (10) 654903 654925 65492B 654929 654936 654950 654953 654972 654987 654993 1 1 GO) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -904- '90-Day Oral Gavage Stu|dSyubinchRraotnsic Toxicity ) 1 1 LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 SPLEEN |1 | NO ABNORMALITY DETECTED 1 1 1 1 1 1 i 1 1 1 (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -905- 90-Day Oral Gavage StJuSduybicnhRroatnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions j LESION INCIDENCE (NUMERIC) Males LESIONS TREATMENT |0 1 mg/kg 1I i 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 11 1 1 THYMUS (20) 1 NO ABNORMALITY DETECTED 1 654903 654909 654910 654915 654924 654925 654927 654928 654929 654936 654943 654949 654950 654953 654956 654972 654987 654992 654993 654994 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (20) j 654914 654921 654942 654951 654955 654957 654965 654973 654974 654976 654977 654978 654979 654983 654985 654986 654990 654991 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBi -906- 90-Day Oral Gavage Stu^dSyuibnchRraotnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (NUMERIC) 1 1 Males 11 -- ~ ~ | LESIONS 1 TREATMENT 0 1 5 25 125 1 1 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX !! 1 ______ __________ ____ __ _ __ ________ _______ ___ ____ j | LYMPHATIC AND HEMATOPOIETIC SYSTEM 1 1 | MANDIBULAR LYMPH NODE |1 | NO ABNORMALITY DETECTED 1 1 l l l 1 1 1 l 1 (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 1 654993 1 11 (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -907- ~90-Day Oral Gavage Stu|dSyuibnchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED TREATMENT LESION INCIDENCE (NUMERIC) Males 0 11 mg/kgj mg/kg I 1 III i 5 mg/kg V 25 mg/kg VII 125 mg/kg IX 1 t 1 io : (9) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 654921 654951 654955 654965 654979 654983 654986 654996 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -908- 90-Day Oral Gavage StuIdSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 1 LESIONS i ] 1 1 ........ LESION INCIDENCE (NUMERIC) Males | \ TREATMENT 1 0 1 1 5 25 I 125 j mg/kgj mg/kg mg/kg mg/kgj mg/kg 1 I 1 III V VII IX .. ___ .. . ... . . 11 j | LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW (10) NO ABNORMALITY DETECTED I 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 1654986 1654996 1655003 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -909- 90-Day OralGavage Stu|dSyuibnchRraotns_ic_T__o_xicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LESION INCIDENCE (NUMERIC) | Males TREATMENT 10 j mg/kg 1I 1 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED (9) 654903 654928 654929 654936 654950 654972 654987 654993 . CYST. 654953 11 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -910- Company Sanitized. Does not contain TSCA CBI a_v_a_g_e_St[u^dSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS . ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED ALTERATION, COLLOID. | TREATMENT 1 1 1 LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg /kg mg/kg I III V VII IX 11 1! (20) (10) (10) (10) (20) 654903 654960 654916 654955 654924 654984 655003 654925 654936 654949 654950 654953 654972 654992 654993 654909 654908 654907 654922 654914 654910 654913 654911 654923 654921 654915 654932 654917 654930 654942 654927 654938 654959 654940 654951 654928 654941 654961 654952 654957 654929 654946 654967 654958 654965 654943 654947 654980 654975 654973 654956 654995 654998 654989 654974 654987 655005 655001 654976 654994 655006 654977 654978 654979 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified -911- DuPont-9478 _9_0_-_D_a_y_O_r_a_l_G_a_v_a_g_e_SPtJuSduybicnhRroatnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX ENDOCRINE SYSTEM THYROID GLAND ALTERATION, COLLOID. (20) (10) ( 10) (10) (20) 654983 654985 654986 654990 654991 654996 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -912- 90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS 1 LESION INCIDENCE (NUMERIC) j 1 Males TREATMENT 0 1 1 5 1 25 ! 125 mg/kg mg/kgj mg/kgj mg/kgj mg/kg I III V 1 VII 1 IX ENDOCRINE SYSTEM PARATHYROID GLANDS NO ABNORMALITY DETECTED (9) 654903 654925 654928 654929 654936 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 654914 654921 654951 654955 654965 654979 654983 654986 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -913- TidSyubinchRraotnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 11 1 LESIONS 11 LESION INCIDENCE (NUMERIC) ! 1 Males I TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX ENDOCRINE SYSTEM ADRENAL GLANDS (10) NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -914- 90-Day Oral GavageSPtjujdsuybicnhRroatnsic Toxicity LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX NERVOUS SXSTEM | BRAIN |1 | NO ABNORMALITY DETECTED l l l l l 1l l l 1 (10) 654903 654925 654928 654929 654936 654950 654953 654972 1654987 1 654993 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA O CD 90-Day Oral Gavage 1ndSyuibnchRraotnsi_c_T_o_x_i_c_it_y LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 111 ___________________ 1 LESION INCIDENCE (NUMERIC) Males TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX NERVOUS SYSTEM , SPINAL CORD (10) NO ABNORMALITY DETECTED 1 1 1 1 1 1 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -916- 90-Day Oral Gavage StujdSyubinehRraotns_ie_T__o_x_ic_i_ty_ ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 | LESIONS 1 1 1 ! _ ____ _ .... _ ___ _______ 1 | NERVOUS SYSTEM 1 1 | SCIATIC NERVE 11 | NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 ! 1 1 TREATMENT _____ _ LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg /kg mg /kg mg/kg mg/kg I III V VII IX (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -917- 90-Day Oral G__a_v_ag_e__StJuSduybicnhRroatnsic Toxicity Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (NUMERIC) Males 0 mg/kg I 1 mg/kg III 5 1 25 1 125 mg/kg1 mg/kg mg/kg V I VII 1 IX 11 MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE (10) 1 I ; NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 ! 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -918- 90-Day Oral Gavage tudSyubinchRraotnsic Tox_ic_i_ty Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions i 1 1 1I | LESIONS 1 TREATMENT ! 1 1 |_____________________________________________________________________ I . . . . . . . i | MUSCULAR AND SKELETAL SYSTEM LESION INCIDENCE (NUMERIC) Males 0 11 15 mg/kg) mg/kg| mg/kg I 1 III 1 V 25 | 125 mg/kgj mg/kg VII j IX 1 1 FEMUR/KNEE JOINT (10) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 1i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -919- Subchronic Toxicity 90-Day Oral Gavage Study in Rats Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS MUSCULAR AND SKELETAL SYSTEM LESION INCIDENCE (NUMERIC) 1--------------------------------1 Males TREATMENT |0 j mg/kg 1I 1 1 mg/kg III 5 mg/kg V 25 I 125 mg/kg1 mg/kg VII j IX 1 STERNUM NO ABNORMALITY DETECTED (10) 654903 654925 654928 654929 654936 654950 654953 654972 654987 654993 (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -920- 90-Day Oral Gavage StudSyuibnchRraotnsic T__o_x_ic_i_ty_ ) LESIONS Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1I1 LESION INCIDENCE (NUMERIC) i Males TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED DILATATION, SEMINIFEROUS TUBULES, UNILATERAL. DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL. DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL. 1 ! 1 (10) 654903 654925 654928 654929 654953 654972 654987 654993 654936 654950 (1) 654980 654980 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654986 654996 655003 654983 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -921- 90-Day Oral Gavage todSyuibnchRraotns_ic_T__o_xicity > Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 i 1 1f | LESIONS 1 I 1 1\ _ _ _ __ __ __ 1 | REPRODUCTIVE SYSTEM ________ _____ ____ 1 1 | EPIDIDYMIDES 1l | NO ABNORMALITY DETECTED l l i l l i l i | OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL. | OLIGOSPERMIA/GERM CELL DEBRIS, BILATERAL. 1 LESION INCIDENCE (NUMERIC) Males j TREATMENT 0 1 mg/kg iI 1 _ ____ ____ _ 1 mg/kg III 5 mg/kg V 25 mg/kg VII 125 mg/kg IX (10) 654903 654925 654928 654929 654950 654953 654972 654987 654993 654936 1 1 (10) 11 654914 654921 654951 654955 654965 654979 654986 654996 1655003 [654983 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -922- 90-Day Oral Gavage StufdSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (NUMERIC) Males 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED 1 : (10) 654903 654925 654929 654936 654950 654972 654987 INFLAMMATION, SUBACUTE/CHRONIC. 654928 654953 654993 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -923- '90-Day Oral Gavage StufdSyubinchRraotnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LESION INCIDENCE (NUMERIC) Males TREATMENT 10 11 1 mg/kg| mg/kg 1 X III 1 5 mg /kg V 25 mg /kg VII 125 mg /kg IX REPRODUCTIVE SYSTEM SEMINAL VESICLES (10) NO ABNORMALITY DETECTED 654903 654925 654928 654929 654936 654950 654953 654972 654987 1 654993 1 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -924- 90-Day Oral Gavage Stu\dSyubinchRraotnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS CUTANEOUS SYSTEM 1 LESION INCIDENCE (NUMERIC) 11 1 Males | TREATMENT 1 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg I III V VII IX SKIN | | NO ABNORMALITY DETECTED 1 ! 1 1 I 1 1 I 1 1 (10) (1) 654903 654908 654925 654928 654929 654936 654950 654953 654972 654987 654993 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -925- 90-Day Oral Gavage StuPdSyuibncRhraotnsic Toxicity ) Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions SPECIAL SENSES SYSTEM LESION INCIDENCE (NUMERIC) Males TREATMENT |0 |1 j mg/kgj mg/kg I 1 III 11 5 mg/kg V 25 mg/kg VII 125 mg/kg IX EYE(S) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT. FOLD/ROSETTE, RETINAL. ADHESION, RETINAL. (10) 654903 654925 654928 654929 654936 654953 654987 654993 654925 654928 654953 654950 654972 (10) I 654914 654921 654951 654955 654965 654979 654983 654986 654996 655003 654965 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -926- Company Sanitized. Does not contain TSCA CBI 90-Day Oral Gavage StujdSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (Animal #) Females j LESIONS | TREATMENT 1 1 1 |0 1 mg/kg 1 II 1 1 mg/kg IV 5 mg/kg VI 25 mg/kg VIII 125 mg/kg X LIVER 1111 (20) 1 (20) NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERPLASIA, BILE DUCT. 655035 655068 655098 655101 655009 655009 655016 655019 655025 655031 655032 655036 655071 655072 655079 655083 655099 655107 655031 655079 655109 FATTY CHANGE, MEDIAN CLEFT. 655015 655016 655025 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 655010 655097 655100 655023 655026 655037 655049 655052 655053 655061 655063 655075 655077 655088 655092 655007 655026 655049 655103 655084 655095 -927- DuPont-9478 90-Day Oral Gavage dSyubinchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LIVER FATTY CHANGE, MEDIAN CLEFT. ANGIECTASIS. LESION INCIDENCE (Animal #) j Females TREATMENT 0 mg/kg II 1 mg/kg IV 5 mg/kg VI 25 1 125 mg/kg| mg/kg VIII j X 1 (20) 655062 (20) 655030 655077 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -928- Company Sanitized. Does not contain TSCA ~90-Day Oral Gavage StuJdSyuibnchRraotnsi_c_T__o_x_ic_i_ty ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS KIDNEYS NO ABNORMALITY DETECTED CHRONIC PROGRESSIVE NEPHROPATHY. I LESION INCIDENCE (Animal #) 11 1 Females 1 TREATMENT 1 1 1 0 mg/kg II 1 mg/kg IV 5 mg/kg VI 25 I 125 mg/kg1 mg/kg VIII 1 X 1 111 (20) 1 (10) (10) 1 (10) (20) 655009 655013 655020 655012 655037 655016 655040 655034 655047 655049 655025 655041 655038 655055 655053 655032 655044 655039 655058 655035 655086 655042 655073 655036 655089 655066 655085 655071 655090 655067 655105 655072 655108 655079 655107 655109 655015 655033 655029 655011 655007 655019 655091 655054 655076 655010 655031 655087 655078 655026 655062 ' 655068 655030 655052 655099 655061 655101 655063 655075 655077 655084 655088 655095 655097 655100 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified O ) DuPont-9478 90-Day Oral Gavag^StuidSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS t LESION INCIDENCE (Animal #) 11 Females TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X KIDNEYS CHRONIC PROGRESSIVE NEPHROPATHY. INFLAMMATION, SUBACUTE/CHRONIC. HYDRONEPHROSIS, .UNILATERAL. HYDRONEPHROSIS, BILATERAL. (20) (10) (10) 655083 655091 655098 655031 (10) (20) 655103 655092 655023 655030 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBt -930- 90-Day Oral GavageStuIdSyubinchRraotnsic Toxicity LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (Animal #) i1 1 Females TREATMENT 0 1 5 25 t 125 mg/kg mg/kg mg/kg mg/kg1 mg/kg II IV VI VIII 1 X LUNGS NO ABNORMALITY DETECTED (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -931- 90-Day Oral Gavage StudSyubinchRraotnsi_c_T__o_x_ic_i_ty_ > Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 j LESIONS 1 1 1 | __ _ __ ____ _______ _ 1 | HEART 11 | NO ABNORMALITY DETECTED l l 1 l l i ! | CARDIOMYOPATHY. I 1 1 1 1 __ ___ ______ TREATMENT LESION INCIDENCE (Animal #) Females 0 mg/kg II 1 15 mg/kg mg/kg IV j VI 1 25 mg/kg VIII 125 mg/kg X (11) 655016 655036 655071 655083 655099 655107 655025 655031 655032 655079 655098 i (10) 1 655023| 655026 655052 655063 655092 655095 655097 655103 655007 655053 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -932- 50-Day Oral Gavage StudSyuibncRhraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 mg/kg II 1 mg/kg IV 5 1 25 mg/kg| mg/kg VI 1 VIII 1 125 mg/kg X SKELETAL MUSCLE iI NO ABNORMALITY DETECTED INFLAMMATION, SUBACOTE/CHRONIC. (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655092 655095 655097 655103 655063 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -933- ~90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1 i LESIONS 1 1 1 TREATMENT LESION INCIDENCE (Animal #> Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X SPLEEN (11) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ') DuPont-9478 Company Sanitized. Does not contain TSCA CBI -934- _90-Day Ora_l_G__a_v_a_ge S_tu|SduybicnhRroatnsi_c_T__o_x_ic_i_ty_ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS AORTA NO ABNORMALITY DETECTED | LESION INCIDENCE (Animal #) 1~ 1 Females 1 TREATMENT 1 1 1 10 1 mg/kg 1 II 1 1 mg/kg IV 5 1 25 mg/kg| mg/kg VI 1 VIII 1 125 mg/kg X (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -935- 90-Day Oral Gavage SHtudSyuibnchRraotnsic Toxicity LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X BRAIN NO ABNORMALITY DETECTED (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 1655107 !1 11 i 1 ! Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -936- 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 | LESIONS 1 1 1 TREATMENT 1 LESION INCIDENCE (Anima] #) ; Females i 0 11 mg/kg| mg/kg II 1 IV ] 5 mg/kg VI 25 mg/kg VIII 125 mg/kg X SPINAL CORD (U) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 i 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -937- 90-Day Oral Gavage S[tujdSyuibnchRraotnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS 1 LESION INCIDENCE (Animal #) i j1 --- 11 1 Females 1 TREATMENT 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X STOMACH (11) 1 NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 i 1 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -938- 90-Day Oral Gavage StudSyuibnchRraotnsic Toxicity 1 1 i LESIONS 1 Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (Animal f) 1 Females TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X DUODENUM (11) NO ABNORMALITY DETECTED 1 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -939- 90-Day Oral Gavage_S_t_uSduybicnhrRoantisc__T_o_x_ic_i_ty_ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions i I 11 1 LESIONS 1 1 1 1_ j | JEJUNUM }I | NO ABNORMALITY DETECTED 1 1 1 I 1 1 1 1 i 1 i LESION INCIDENCE (Animal #) Females j 1 TREATMENT 0 j mg/kg 1 II I 1 mg/kg IV 5 mg/kg VI 25 I 125 mg/kg| mg/kg VIII | X (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -940- 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS ILEUM NO ABNORMALITY DETECTED | LESION INCIDENCE (Animal #) 1 --1 Females | TREATMENT 1 1 1 0 1 1 5 25 125 mg/kgj mg/kg mg/kg mg/kg mg/kg II 1 IV VI VIII X (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -941- 90-Day Oral Gavage iudfSyuibncRhraotnsic Toxicity LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 I 125 mg/kg mg/kg mg/kg mg/kg| mg/kg II IV VI VIII | X PANCREAS (11) NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 1 i INFLAMMATION, SUBACUTE/CHRONIC. 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 11 11 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655095 655097 655103 655092 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -942- 90-Day Oral Gavage tudSyuibnchRraotnsi_c_T_o_xicity ) Microscopic Observations in Female Rats Listing individual Animals Affected Neoplastic and Non-Neoplastic Lesions i 1 1 1 | LESIONS 1 i ! I_ __ ___ 1 CECUM _____ _ _ ____ 1 TREATMENT 1 1 i LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X (11) (10) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 !655107 1 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -943- 90-Day Oral Gavage ^tJusduybicnhRroatnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 11 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X COLON (11) NO ABNORMALITY DETECTED l l i l i l l l 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not, identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -944- 90-Day Oral Gavage StudSyuibncRhraotnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neciplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (Animal #) 1 1 ----- 1 1 11 l LESIONS _ ______ _ | TREATMENT 0 Females 1 5 25 125 1 i mg/kg mg/kg mg/kg mg/kg mg/kg 1 1 II IV VI VIII X 11 1- _ _ _ _ _ _ _ ____ _________ _______ _____ 1 | RECTUM 1l | NO ABNORMALITY DETECTED l l l ! 1 1 1 1 1 1 1 (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBJ -945- ) 90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Microscopic observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS 1 LESION INCIDENCE (Animal #) 11 1 Females | TREATMENT 1 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X MESENTERIC LYMPH NODE (11) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA O 00 90-Day Oral Gavage Stu(dSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS SALIVARY GLANDS NO ABNORMALITY DETECTED LESION INCIDENCE (Animal #) Females | TREATMENT 1 1 1 |0 mg/kg II 1 1 mg/kg IV 5 mg/kg VI 25 mg/kg VIII 125 1 mg/kg x (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -947- 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity ) 1 1 1 1 | LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X MANDIBULAR LYMPH NODE Ul) NO ABNORMALITY DETECTED 1 1 i 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -948- 90-Day Oral Gavage StjuSduybicnhRroatnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X THYMUS NO ABNORMALITY DETECTED ( 11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -949- 90-Day Oral Gavage Stu|dSyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS ADRENAL GLANDS NO ABNORMALITY DETECTED MINERALIZATION. LESION INCIDENCE (Animal #) Females 1 TREATMENT 1 1 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X 1 | (11) 1i |655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 1 1 <10i 1 1 6550071 6550231 655026 655053 655063 655092 655095 655097 655103 655052 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -950- 90-Day Oral Gavage Study in Rats Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LESION INCIDENCE (Animal #) Females TREATMENT !0 1 mg/kg 1 II 1 1 mg/kg IV 5 mg/kg VI 25 mg/kg VIII 125 mg/kg X SCIATIC NERVE (11) NO ABNORMALITY DETECTED 1 1 1 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -951- 90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS LESION INCIDENCE (Animal #) Females TREATMENT | 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X PITUITARY GLAND (12) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655062 655071 655079 655083 655098 655099 655107 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 > DuPont-9478 Company Sanitized. Does not contain TSCA CBI -952- _9_0_-D__a_y_O__ra_l_G_avage StuIdSyubinchRraotnsic Toxicity ) LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 LESION INCIDENCE (Animal #) 11 1 Females TREATMENT 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X THYROID GLAND NO ABNORMALITY DETECTED (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -953- 90-Day Oral ubchronic Toxicity avage Study in Rats Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 1 25 125 mg/kg mg/kg mg/kg| mg/kg mg/kg II IV VI VIII X PARATHYROID GLANDS NO ABNORMALITY DETECTED (9) 655016 655025 655031 655032 655071 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 655007 655023 655026 655052 655053 655063 655092 655095 655097 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -954- | Subchronic Toxicity 90-Day Oral Gavage Study in Rats ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 mg/kg II 1 15 mg/kg1 mg/kg IV 1 VI 1 25 mg/kg VIII 125 mg/kg X TRACHEA (11) NO ABNORMALITY DETECTED i 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 1 DuPont-9478 Company Sanitized. Does not contain TSCA CBI -955- 90-Day Oral Gavage StuFdSyuibncRhraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 1 11 0 mg/kg II 1 15 mg/kg| mg/kg IV 1 VI 1 25 mg/kg VIII 125 mg/kg X ESOPHAGUS NO ABNORMALITY DETECTED 1 1 | INFLAMMATION, SUBACUTE/CHRONIC. | LACERATION. 1 (11) 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 655071 655071 I1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -956- 90-Day Oral Gavage StujdSyubinchRraotnsic Toxicity ) LESIONS Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESION INCIDENCE (Animal #) 1 Females TREATMENT 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X PHARYNX/LARYNX 1 (Hi 1 NO ABNORMALITY DETECTED 1 1 1 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10! 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -957- ) 90-Day Oral Gavage Stu'dSyubinchRraotnsic Toxicity ) i j 1 1 j LESIONS 1 Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions TREATMENT LESION INCIDENCE (Animal #) Females 0 1 5 25 I 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII | X EYE(S) WITH OPTIC NERVE (11) NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT. FOLD/ROSETTE, RETINAL. 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655092 655095 655097 655103 655063 655063 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -958- "90-Day Oral Gavage StuIdSyubinchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 LESION INCIDENCE (Animal #) ! ! Females 1 LESIONS 1 1 1 1 1 | SKIN 1I | NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 1 1 1 1 TREATMENT 0 1 5 25 1 125 mg/kg mg /kg mg/kg mg/kg1 mg/kg II IV VI VIII 1 X 1 . (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -959- 90-Day Oral Gavage Stu^dSyuibnchRraotns_ic_T__o_x_ic_i_ty_ ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 11 LESIONS | TREATMENT 1 1 1 LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X MAMMARY GLAND (FEMALE) (11) NO ABNORMALITY DETECTED l l l l l l l 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (8) 655007 655023 655026 655052 655053 655063 655095 655097 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -960- 90-Day Oral Gavage StudyubinchRraotnsi_c_T__o_x_ic_i_ty Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions | 1 111 | LESIONS l l l j -- l OVARIES - - -- -- ------ | TREATMENT 1 l l - --- | LESION INCIDENCE (Anima) #) 1- i * 0 mg/kg Females 1 5 25 mg/kg mg/kg mg /kg 125 mg/kg II IV VI VIII X (11) (10) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 1655107 1 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -961- 90^ayQral Gavage StudSyubinchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 11 1 i 1 LESIONS 1 1 1 1 . ... i 1 UTERUS 1I | NO ABNORMALITY DETECTED l l l l i i l 1 i l [ DILATATION. 1 ... TREATMENT LESION INCIDENCE (Animal #) Females 1 1 0 11 mg/kg| mg/kg II- 1 IV 1 5 1 25 mg/kg| mg/kg VI 1 VIII 1 125 mg/kg X (12) 1 (10) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 655019 1 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -962- __9_0_-D__a_y_O_r_a_l_G__av_a_g_e__S_tupdSyuibnchRraotnsic Toxicity ) Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 1 1 1l | LESIONS 1 | TREATMENT 1 LESION INCIDENCE (Animal #) Females 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg /kg II IV VI VIII X | . _ _____ ___________________________________ i______________ 1 | URINARY BLADDER (11) (10) NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. 655016 655025 655031 655032 655036 655071 655079 655083 655099 655107 655098 11 1 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence, of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -963- Ij9^0B-DHayHOHralHGHavaHgeSSutubdcyhinroRantsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions ! 111 1 LESIONS 1 ! LESION INCIDENCE (Animal #) 1 1 ____ __ ____ Females 1 TREATMENT 1 0 1 5 25 125 mg/kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X !,,...____ ______________________________________ i _ i FEMUR/KNEE JOINT . (11) (10) NO ABNORMALITY DETECTED 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 I 1 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -964- "90-Day Oral Gavage StuIdSyuibnchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions LESIONS 1 11 LESION INCIDENCE (Animal __#_)____ I1 1 1 Females TREATMENT 0 1 5 25 125 mg /kg mg/kg mg/kg mg/kg mg/kg II IV VI VIII X STERNUM (11) NO ABNORMALITY DETECTED 1 1 1 1 | 1 1 1 1 1 1 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 655107 1 1 1 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 1 1 ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -965- 90-Day Oral avage StudyuibnchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1 11 11 LESIONS 1 1 1 1 ... .. __ ...... i j BONE MARROW 1 1 | NO ABNORMALITY DETECTED l l l ! 1 1 1 1 1 | HYPERPLASIA, GRANULOCYTIC. 1 __ .. 1 LESION INCIDENCE (Animal 11 1 Females 1 TREATMENT 0 mg/kg II 1 mg/kg IV 5 mg/kg VI 25 1 125 mg/kg| rag/kg VIII 1 X 1 (11) 655016 655025 655031 655032 655036 655079 655083 655098 655099 655107 655071 1 1 1 (10) 655007 655023 6550261 655052j 6550531 655063 655092 655095 655097 655103 ( Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified ) DuPont-9478 Company Sanitized. Does not contain TSCA CBI -966- 90-Day tudyuibnchRraotnsic Toxicity Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions 1j 11l | LESIONS i1 ____________________________ __ _ _ _ _ _ _ _ _ _ _ _ _ j | NOSE I | NO ABNORMALITY DETECTED 1 1 1 1 1 1 1 1 1 1 1 __ __ _____ 1 TREATMENT 1 L . ..., LESION INCIDENCE (Animal # ) 11 Females j i 0 mg/kg II 1 mg/kg IV 5 mg/kg VI 25 I 125 I mg/kg| mg/kgj VIII 1 x 1 1 (11) 655016 655025 655031 655032 655036 655071 655079 655083 655098 655099 1 655107 1 1! 1 (10) 655007 655023 655026 655052 655053 655063 655092 655095 655097 655103 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified DuPont-9478 Company Sanitized. Does not contain TSCA CBI -967-