Document N2dvgOXqJ4gaN71dNEVNJ39Gg

3/ 1/ 76.3 What is TOXLINE? ` TOXLINE TOXLINE (TOXicology Information on-LINE) is the National Library of Medicine's extensive collection of computerised toxicology information containing over 320,000 references to published human and animal toxicity studies, effects of environmental chemicals and pollutants, adverse drug ronciii" and analytical methodology. This rapidly expand ng data ha- . assembled by the Toxicology Information Program, contains In' bibliographic citations, almost all with abstracts and/or indexing terms, and Chemical Abstracts Service (CAS) Rcgistr numbers, from primary journals 1971 forward. Older- i il ormai i is in the TOXLINE Backfilc, TOXDACK. TOXLINE information is derived from five major secondary sources and three", spec i a I collections of material. The component subfiles currently providing TOXLINE material are: 1. Chemical Abstracts Service: Chemical-Biological Activities (CBAC) , from 1965. 2. BioSciences Information Service: Abstracts on Health Effects of Environmental Pollutants, from 1972. 3. American Society of Hospital Pharmacists: Internationa1 Pharmaceutical Abstracts, from 1970. 4. National Library of Medicine: Toxicity Bibliography, from 1968. 5. Environmental Protection Agency: Pesticides Abstracts, from 1966. 6. Hayes File, on Pesticides 1940-1966. (citations only) 7. lin-i roniTK-n I a 1 Mutagen Informal ion Center. Oak Ridge National Laboratory, from 19(>H, 8. Toxic Materials Information Center File, Oak Ridge National Lahor.il orv, I mn L971. 1)1 I'\K I Ml Nt (Mill M 111. I Dl'l M It >'* ' I) M I I I I'd r.ilil'i I V ! 1 ,1 'i.ai.ii.-. ... I . GENC 011099 * How is TOXLINE accessed? How is TOXLINE searched ? CTOXLINE Is accessed by a large variety of typewri t er-111.. terminals connected to a central computer facility locat'd ^ at the National Library of Medicine in Bethesda. Maryland, by direct telephone line or via a nationwide network using telephone lines and small computers with access nodes located in many major cities. Citations on a given Subject may be retrieved from TOXLINE by entering the desired free text terms as they appear In titles, keywords, and abstracts of articles. Chemical sub stances can be entered by their corresponding Chemical Abstract Service Registry numbers after consulting the CHEMLLNE file. There is no controlled vocabulary governing the inclusion or exclusion of terms in TOXLINE-. Terms may he entered singly or combined by means of the Boolean operators AND, OR, and AND NOT Searches may be limited to specific years of publication, seco-i dary sources, or authors, since these are all searchable cli-rm-n Citations and abstracts may be printed on-line al the user's terminal, or off-line and mailed to the user from NI.M. Usi. rs may select a print format varying from a brief Identification author(s), title, and source to a complete listing of the hibli graphic record, including the abstract. What time period is covered by TOXLINE? Where is TOXLINE available? When is TOXLINE available? TOXLINE contains bibliographic citations and abstracts from 1971 primary journals forward. Older information is in a TOXLINE Backfile, TOXBACK. TOXBACK contains approximately 200,000 records, available by OFFSEARCH. TOXLINE Is available at approximately 200 organizations. including academic, commercial and government agencies. ^ TOXLINE is available Monday. Wednesday, Thursday, and Frld.iv from 3:00 a.m. to 5:00 p.m. (Eastern Time) and Tuesday from 12 noon to' 10:00 p.m. How much does TOXLINE cost? Effective July 1, 1975, the cost of the National Library of Medicine's on-line data bases Is $15 for each hour of compel' r connect time between 10 a.m. and 5 p.m. Eastern Time and $8 an hour at all other times. The Library also charges 10c for each page of off-line print-out; and $1,00 per file per OFFSEARCH. Subscribing institutions may recover these costs as well as the cost of a search analyst's time from their customers. How does one subscribe to TOXLINE? Institutions wishing to become TOXLINE subscribers must sign agreements with the National l.ihrary of Medicine and with its billing agent, the National Technical Information Service. Subscribing institutions must agree to send one professional staff member for a ilir< e-day training course. For further information,, interested institutions should contort: Bruno M. Vasta, ChieT Toxicology Information .Services National Library of Medicine 8600 Rockville Pike Bethesda, Maryland J0014 GENC 011100 Maryland 20014 CHEMLINE* What is CHEMLINE? . Chemune (CHEMical Dictionary on-LINE) is the National Library of Medicine's on-line, interactive chemical dictionary file created by the Specialized Information Ser vices in collaboration with Chemical Abstracts Service (CAS). It provides a mechanism whereby 070,000 chemical substance names representing over 77,000 unique substances, can be searched and retrieved on-line. This file contains CAS Registry Numbers, molecular formulas, pre ferred chemical nomenclature, generic and trivial names derived from the CAS Registry Nomenclature File, and a limited number of Wiswesser Line Notations (WLN). In addition, each Registry number record in chemline -con tains, where applicable, ring information including: num--j ber of rings, ring sizes, ring elemental analysis, and com- ' ponent line formulas. How is CHEMLINE accessed? CHEMLINE is accessed by a large variety of typewriter-like terminals connected to a central computer facility located at the National Library of Medicine in Bethesda, Maryland. The communications linkage is provided by a nationwide network using telephone lines and small computers with access nodes located in many cities. How is CHEMLINE searched? The user searches CHEMLINE by entering a chemical name, a generic name, trivial name, company identification name, or its equivalent molecular formula. If the exact name of a chemical substance is unknown, a search may be conducted using the Boolean operator AND to connect those fragments of the name, ring analysis terms, and- or molecular formula which are known. This feature also allows searching at a substructure level. Thus, for example, each of the following search entries would retrieve information about the chemi cal chlorpromazine: Generic Name: CHLOUPROMAZ1NF, Chemical Name: 2-CHI,ORO-lO-(3- D1METJIYLAMINO) PROPYL) PHFNOTHIAZINE DEPARTMf NT OF HEALTH, EDUCATION, AND WELFARE Puhlu Ht-jllh Servifi- Njliorul Institutes of GEMC 01 not  Nomenclature & Locant Fragments: 2 CHLORO 10 3 DIMETHYLAMINO PROPYL PHENOTHIAZINE Molecular Formula: C17-H19-CL-N2-S CAS Registry Number: 60-63-3 Trivial Name: Synonyms: CFZ LARGACTYL. PROMAZIL. THORAZINE Ring information for this compound include: Number of Rings: 3 Ring Size: 6,6,6 Elemental Composition: C4NS-C6-C6 Component Line Formula: NC2SC2 From the structure of Chlorpromazine Cl I CHiCHCHiN (CHj), When is CHEMLINE available? How much does CHEMLINE cost? How does one subscribe to CHEMLINE? one can readily determine that it has 3 rings; they are all 6-membered rings; the elemental composition is C4NS for the middle ring and'C6 for both outside rings; the component line formula describes .the sequence of con nectivity between atoms of the middle ring. CHEMLINE is available at NLM from 3:00 a.m. to 5:00 p.m. Monday, Wednesday, Thursday and Friday, and from noon to 10:00 p.m. on Tuesday. CHEMLINE, like all of NLM's on-line data bases, costs $15 per hour for computer connect time between 10:00 a.m. and 5:00 p.m., Eastern Time, $8 per hour at all other times, and 10? per page of off-line print-out. CHEMLINE is included in the subscription to cither medline or TOXLINE. For further information, interested institutions should contact: Bruno M. Vasta, Chief Toxicology Information Services National Library of Medicine 8600 Rockville Pike Bethesda, Maryland 20014 GENC 011102