Document MM1mayBYExGoQX38Mk9bJ1Xea

Vista Chemical Company 900 Threadneedle Houston, Texas 77079 (713} 588-3000 September 26, 1989 P.O. Box 19029 Houston, Texas 77224 Fax (713} 568-3236 TG: J0L: MUG: AJO: RF XF: . 'z ^ , i Mr. Keith Thomas Vice President Technology Pennzoil Research P. 0. Box 7569 Woodlands, TX 77387 Dear Keith: Per your discussion with Ron Bryan and Carl Kerfoot, enclosed are toxicity studies that we have available on the dialkylbenzene, synthetic lubricant base oil stream that you are discussing and considering evaluating. The studies conducted are an acute oral LD50 dermal and eye irritation. In summary this material is non-toxic by ingestion ana non-irritating to the eye and skin. Several items should be noted. This testing was done in 1975 and may not meet all the requirements of current Good Laboratory Practices regulations. Also the product stream of interest was called "Conoco" BB0 at that time. This is essentially the same stream currently being considered. Please call me at 713-588-3445 if you have questions on the enclosed. Sincerely, -------- Thomas G. Grumbles, C.I.H. Environmental Quality Manager dlj Enclosures cc: Mike Clark, Ron Bryan 0. C. Kerfoot-Austin VVV 000014114 Scientific Associates, 9 INC. 6200 S. LINDBERGH. ST. LOUIS. MO. 63123 . TELEPHONE: 314-487-6776 - 2- EXPERIMENTAL PROCEDURE: (continued) Following the observation period, all surviving animals were weighed, sacrificed and necropsled. RESULTS 2 The mortality results during the observation period of 14 days are presented below* Values represent number of dead/number of animals tested, cumulative* Dosage TIME OF DEATH FOLLOWING DOSAGE Level (Days) gm./kg.* 1 2 3 4 5 6 7 8 9 10 11 12 13 14 % Mortality 20.00 28.25 39.91 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 0/10 *Specific gravity * 0.8371 @ 23Centigrade 0 0 0 Dosage Level gm./kg.* ORAL LD_. M5O0R-T--A--L--I-T-Y-----D--A--T-A-Mortalitv/Number of Animals 7. Mortality 20.00 28.25 39.91 0/10 -(OM, OF) 0/10 (OM, OF) 0/10 (0M, OF) *Specific gravity 0.8371 @ 23Centigrade -0 0 0 There were no mortalities at any dosage level tested. The acute oral LD^ of "ConGco*1 BBO, Sample No. 8558H, 3-14-75, when administered undiluted to young adult male and female SASC0 rats is therefore greated than 39.91 g./kg. of body weight (highest dosage level tested). Animals at all dosage levels exhibited no gross signs of toxicity. Final body weight records of survivors at termination showed weight gains within'expected limits. Gross necropsy of animals sacrificed at termination showed the tissues to be not remark able. SCIENTIFIC ASSOCIATES, INC. S. A. Number 204668 bd Robert H. Moulton Vice-President and Director Biological Research Services Vi/u _ v 00J4II5 This is a confidential report which may not be used in any form of advertising without written permission. Scientific Associates, me. 6200 S. LINDBERGH. ST. LOUIS. MO. 63123 TELEPHONE: 314.467-6776 August 7, 1975 SUBJECT: Dermal Irritation Test in Rabbits SAMPLE DESIGNATION: "CONOCO" BBO Sample No. 8558H 3-14-75 S. A. Number 204668 SUBMITTED BY: CONOCO Continental Oil Company Ponca City, Oklahoma SUMMARY AND CONCLUSION: "Conoco" BBO, Sample No. 855H, 3-14-75, when applied undiluted to the intact and abraded skin of six New Zealand albino rabbits was found to produce no apparent skin damage, with a Primary Irritation Index of 0. As the term is defined in the Federal Hazardous Substano Act (FHSA), the product was not found to be a Primary Irritant. EXPERIMENTAL PROCEDURE: Six New Zealand albino rabbits were used to determine the degree of dermal irritation resulting from the topical application of "Conoco" BBO, Sample No. 8558H, 3-14-75 to the skin. Hie animals were individually housed in metal cages elevated above the droppings with feed, consisting of Purina Rabbit Chow, and tap water freely available at all times. Hie backs of the animals were clipped free of hair and the skin examined before testing. Only those animals without skin defects or irritation were used. Abrasions (minor incisions through the stratum corneum, but not sufficiently deep to distrub the derma) were made on one area of the backs, while another area was left intact. The animals were Immobilized in animal holders, and 0.5 ml. undiluted of "Conoco" BBO, Sample No. 8558H, 3-14-75 was applied under each of two one-inch square gauz patches to the prepared areas on the back of each rabbit. After the patches had been secured by adhesive tape, the entire trunk of each animal was wrapped with a plastic binder to keep the material in position and in contact with the -skin for 24 hours. Following the 24 hours of exposure, the patches were removed; any remaining material was washed off the treated areas, and the resulting reactions evaluated using the scoring method of DraizeT'Woodward and Calvery (J. Pharmacol. Exptl. Therap., 82, 377, 1944), 'as given on the following page. VVV 000014116 This is confidential report which may not be used in any form of advertising without written permission. Scientific Associates, 6 INC. - 2EXPERIMENTAL PROCEDURE: (continued) Value Erythema and eschar formation: No erythema Very slight erythema (barely perceptible) Well-defined erythema Moderate to severe erythema Severe erythema (beet redness) to slight eschar formation (injuries in depth) Total possible erythema score 0 1 2 3 4 4 Edema formation: No edema Very slight edema (barely perceptible) Slight edema (edges of area well-defined by definite raising) Moderate edema (raised approximately 1.0 mm.) Severe edema (raised more than 1,0 mu. and extending beyond the area of exposure) Total possible edema score 0 1 2 3 4 4 The average values for erythema and eschar formation at 24 hours and 72 hours for the intact skin areas of exposure were added to the average values of the abraded skin areas of exposure at 24 hours and 72 hours (four values). Similarly, the average values for edema formation at 24 hours and at 72 hours for the intact and abraded skin areas of exposure were added (four values). The Primary Irritation Index is the total of the eight average values divided by four. According to the FHSA method of testing, a Primary Irritant is a substance which produces a skin reaction resulting In a score of five or greater. RESULTS: The scores for the 24, 48 and 72-hour observations are given below: Rabbit No. 24 Hours I* A* 48 Hours IA 72 Hours IA 1 2 Erythema and Eschar Edema Formation Erythema and Eschar Edema Formation 0 0 0 00 0 00 0 00 0 00 0 00 0 00 0 00 0 3 Erythema and Eschar Edema Formation 0 0 0 00 0 0 0 0 00 0 A Erythema and Eschar Edema Formation 0 0 0 00 0 0 b 0 00 0 K Erythema and Eschar Edema Formation 00 0 00 0 00 0 00 0 f. Erythema and Eschar Edema Formation 00 0 00 0 0 0 0 00 0 Erythema and Eschar Average Value Edema Formation Average Value 00 00 0 -0 00 0 0 0 0 I* = Intact A* =* Abr`J'>^ S. N. Number 204668 VVV 0000l4il? This is confident!*! report which may not be used in m\y form of advertising without written permission. f ientific Associates. e INC. 6200 S. LINOBERGH. ST. LOUIS. MO. 63123 TELEPHONE: 314-407-6776 * -3- RESULTS: (continued) "Conoco" BBO, Sample No. 8558H, 3-14-75, when applied undiluted to the intact and abraded akin of New Zealand albino rabbits, caused no apparent skin irritation during the 72 hour test period. SCIENTIFIC ASSOCIATES, INC. BY: Robert H. Moulton * Vice-President and Director Biological Research Services WV 000014116 S. A. Number 204668 bd This is confidently report which may not be used in any form of advertising without written permission. ientieic Associates, e INC. 6200 S. LINDBERGH. ST. LOUIS. MO. 63123 TELEPHONE: 314-487-6776 SUBJECT: SAMPLE DESIGNATION: Eye Irritation Test in Rabbits "CONOCO" BBO Sample No* 8558H 3-14-75 S. A* Number 204668 August 7, 1975 SUBMITTED BY: CONOCO Continental Oil Company Ponca City, Oklahoma SUMMARY AND CONCLUSION: "Conoco" BBO, Sample No. 8558H, 3-14-75, when instilled undiluted into the conjunctival sac of six New Zealand albino rabbits and the treated eyes not washed following instilla tion of the test material, produced within 1 hour only slight ocular irritation in the form of slight erythema (6/6 test eyes), slight chemosis (5/6 test eyes), and slight discharge (6/6 test eyes). No corneal opacity was observed. The test eyes returned to normal within the 72 hour observation period. A maximum average score of 5.0 was recorded at 1 hour. As the term is defined In the Federal Hazardous Substances Act (FHSA),' the material "Conoco" BBO, Sample No. 8558H, 3-14-75 vas not found to be an Eye Irritant. EXPERIMENTAL PROCEDURE: Six New Zealand albino rabbits were used to determine the degree of ocular irritation resulting from the addition of the test material, "Conoco" BBO, Sample No, 8558H, 3-14-75 into the conjunctival sac of the animals. The animals were Individually housed in metal cages elevated above the droppings with feed, consisting of Purina Rabbit Chow, and tap water freely available at all times. Both eyes of each animal were examined with Fluorescein Sodium Ophthalmic Solution U.S.P. 4 hours before testing, and only those animals without observable eye defects or Irritation were used. One-tenth milliliter of "Conoco" BBO, Sample No, 8558H, 3-14-75 was placed in one eye - of each animal by gently pulling the lower lid away from the eyevall to form a cup into which the test material was deposited. The lids were then gently held together for one second and the animal was released. The other eye was not treated and served as a control. The eyes were not washed following instillation of the test material except as noted below. All animals were immobilized In a suitable animal restrainer for 1 hour subsequent to treatment. VVV 000014119 This is a confidential report which may not be used in any form of a dvertisin* without written permission. Scientific Associates, Tnc 6200 S. LINDBERGH. ST. LOUIS. MO. 63123 TELEPHONE: 314-407-6776 EXPERIMENTAL PROCEDURE: (continued) -2- The eyes were examined and the grade of ocular reaction was recorded at 1, 24, 48, and 72 hours, using the scale for scoring ocular lesions as outlined by Lehman, A.J., et. a_l., in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics Assoc., Food and Drug Officials of the U.S., Second Printing, Topeka, Kansas 1965. The evaluation of the data was in accordance with Section 1500.42, Chapter 2, Title 16, Code of Federal Regula tions under the FHSA. After the Initial examination at 24 hours all eyes were washed with sufficient clean tap water at body temperature to remove the residual test sample. All eyes were further examined by placing one drop of Fluorescein Sodium Ophthalmic solution U.S.P. on the cornea. After 5 minutes the excess fluorescein was flushed out with sufficient tap water. Fluorescein Sodium in 27. aqueous solution when applied topically to the eye is used as an ophthalmic diagnostic aid for the detection of corneal lesions. Injured areas of the cornea appeared greenish yellow following application of fluorescein. RESULTS: A summary of the scores for the 1, 24, 48, and 72 hour observations is given below: Rabbit No. Structure 1 Hour 24 Hours 48 Hours 72 Hours 1 2 3 4 5 6 Cornea Iris Conlunctivae Cornea Iris Conlunctivae Cornea Iris Conlunctivae Cornea Iris Conlunctivae Cornea Iris Conlunctivae Cornea Iris Conlunctivae Average 00 0 0 00 0 0 40 0 0 00 0 0 00 0 0 62 0 0 00 0 0 00 0 0 60 0 0 00 0 0 00 0 0. 44 0 0 00 0 0 00 0 0 64 0 0 00 0 0 00 0 0 42 0 0 5.0 2.0 0.0 0.0 VVV 000014120 S. A. Number 204668 This ie confidential report which may not be used in any form of edvertising without written permiesion. Scientific Associates, W 6200 S. LINDBERGH. ST. LOUIS. MO. 63123 . TELEPHONE: 314.467.6776 - 3RESULTS: (continued) "Conoco" BBO, Sample No. 8558H, 3-14-75, when instilled undiluted into the conjunctival sac of six New Zealand albino rabbits and the treated eyes not washed following instilla tion of the test material, produced within 1 hour only slight ocular irritation in the form of slight erythema of the bulbar and palpebral conjunctlvae (6/6 test eyes), slight chemosis of the lids (5/6 test eyes), and slight discharge (6/6 test eyes). No corneal opacity was observed* The test eyes returned to normal within the 72 hour observation period* A maximum average score of 5*0 was recorded at 1 hour* SCIENTIFIC ASSOCIATES, INC. BY; Robert H* Moulton Vice-President and Director Biological Research Services S* A* Number 204668 bd VVV 000014121 This is confidential report which may not be used in ny form of advertising without written permissicn. (1) Cornea SCALE FOR SCORING OCULAR LESIONS* (A) Opacity-degree of density (area most dense taken for reading) No Opacity ................................................................................................................................ 0 Scattered or diffuse area, details of iris clearly visible ..... 1 Easily discernible translucent areas, details of iris slightly obscured............................ ............................................................ ....................... ... 2 Opalescent areas, no details of iris visible, size of pupil barely discernible. .... ........................ . ................... ....... 3 Opaque, iris invisible................................. ...................................................................... 4 (B) Area of cornea involved One quarter (or less) but not zero................... .... ................................................1 Greater than' one quarter, but less than half............................. . 2 Greater than half, but less than three quarters................................. 3 Greater than three quarters, up to whole area. ..... ................... 4 Score.equals A x B x 5 Total maximum 80 (2) Iris (A) Values Normal ........ ........................ .... ........................ ....... 0 Folds above normal, congestion, swelling, circuracorneal injection (any or all of these or combination of any thereof) iris still reacting to light (sluggish reaction is positive ........................ . 1 No reaction to light, hemorrhage, gross destruction (any or all of these) ............................................... ............................................................................... 2 Score equals A x 5 Total maximum ~ 10 (3) Conjunctivae (A) Redness (refers to palpebral and bulbar conjunctivae excluding cornea and iris) Vessels normal ........................ . . ............................................... 0 Vessels definitely injected above normal............................................... . . . . 1 More diffuse, deeper crimson red, individual vessels not easily discernible ................... .......... ................... ................................. 2 Diffuse beefy red ..................................................................................... 3 (B) Chemosis No swelling............................ ................................................................. ........................ ...0 Any swelling above normal (includes nictitating membrane) ........................ .1 Obvious swelling with partial eversion of lids. . . . ......................... .... 2 Swelling with lids about half closed 3 Swelling with lids about half closed to completely closed ....... 4. (C) Discharge No discharge ............................ .................................................................. .... 0 Any amount different from normal (does not include small amounts observed in inner canthus of normal animals) ........................ 1 Discharge with moistening of the lids and hairs just adjacent to lids.................................................................. .... ................................................................. 2 Discharge with moistening of the lids and hairs, and considerable area around the eye........................ .... ............................................................ ..... 3 Score equals (A + B C) x 2 Total maximum 20 The maximum total score is the sum of all scores obtained for the cornea, iris, and conjunctivae. Total maximum score possible ~ 110. *Xehman, A.J. et al., Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics, Assoc. Food and Drug Officials of the U.S., Austin Texas, 1959 S.A. Form 14-A VVV 000014122 Vista Chemical Company 900 Threadneedie Houston, Texas 77079 (713) 588-3000 P.O. Box 19029 Houston, Texas 77224 Fox (713) 588-3236 September 26, 1989 T6G: m.. XF: i AJ0: RF Mr. Paul Hogen Daubert Chemical 4700 S. Central Avenue Chicago, Illinois 60638 VISTA Dear Paul: This letter is in response to your questions regarding the status of Vista N-500, N-600L, and V-3050 Specialty Alkylate under 40 CFR 261 and California Proposition 65. 40 CFR 261 is the section of federal regulations that define hazardous waste. These Vista products are not listed by name nor do they exhibit defined characteristics in 40 CFR 261 that would cause them to be classed as hazardous waste. As to California Proposition 65, based on current analytical data and methods, these products contain no detectable quantities of the chemicals listed by California Proposition 65. Please call me at 713-588-3445 if you have questions on the above. Sincerely, Thomas G. Grumbles, C.I.H. Environmental Quality Manager dlj cc: Tanya Gillette VVV 000014123 TO: John Roheim-Austin TGG: JCL: AJO: RF XF: ___ _____________ Interoffice Communlcotion FROM: DATE: SUBJ: T. G. Grumbles September 26, 1989 Multiple Items for "Coordination" VISTA As we have discussed, I see a need for us to schedule some time to discuss multiple items of mutual need and areas where we need to assure coordination and influence action. I think we should wait for Dr. Penny to get here. Below is a preliminary list. 1. GLP regulations and in-house testing. 2. Shipping Transfer and Storage Manual. a. Revision b. Maintenance 3. PMN testing requirements. 4. Vista Toxicology Assessment Committee a. Structure b. Future "functioning" 5. MSDS preparation and review. 6. Existing toxicological database. 7. Product Liability/New Product Development Process. 8. SDA activities and committees. As you can see, we'll probably need a day or more to achieve appropriate attention and planning. Also, the list will grow before we meet. I would suggest a meeting in mid October in Austin. Thoughts? T. G. Grumbles dlj VVV 000014124