Document LkjRXxZq9w9g0jqm7z3edO7Q
AR226-3357
Application of L G M S /M S Methodology to Determination < Telomer B Alcohols, Perfluorinated Acids, and Fluorosurfactants in Environmental M atrices.
Boadan Szostcft. Vladimir CapkA, Keith B. Pricket*. S . M ark Kennedf, Robert C. BucR
1DuPont Haskell Laboratory fo r Health and Environmental Scienc4Q90 Elkton Rd., Newark, DE 19714, U SA 2 DuPont Chemical Solutions Enterprise. Wilmington. DE. U S A
- analytical methodology for measurement of perfluoroalkyl subsfee in various biological and environmental matrices
continues to be a challenging task despite tremendous progressfhis field in recent years;
.
- the purpose of this work was the development of analytical radfafor determination of Telomer B Alcohols (TBAs; anl
selected perfluorinated acids utilizing LC /M S and L C /M S/M S;
._ .
- Telomer B Alcohols are intermediates for manufacturing of a fahrange of anionic, nonionic fluorosurfactants, ana
- Telomer B Alcohols based products are brtad! usea in vorieilyaBnsumer products asfluorosurfactants or water/sGil
repelling coatings for paper, textiles, and carpets;
.........
,
- extraction and quantitation by L C /M S /M S of four selected peoftaated acids, potential biodegradation products of
8-2 TBA, were investigated;
Telomer B Alcohols by L C /M S and L C / M S / M S
Introduction:
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8 - 2 T B^ A b y L C / M S
Internal Standard
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Chromatographic conditions:
j CIP fragmentation)
6-2 TBA, 10 eV
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8-2 TBA, 10 eV
Chromatographie conditions-
Calan- Store MSRIS, 1.
S* ttsWfe w w : * w w r B Gra.-5.v-: TSo
mKm *
'7/.1 |(iW0.1;?-
M S conditions: I1nnonlfNoc'jvot:'rrt:dGwbtt*i!rr.eMy,rrew;eWoWv*rMn* Cnic*etmvaoiniisiyo:SipVitay: .10tV
CPTraw-VsnWxiSiatvcnTnKiEorv,,-:-Ro.'r-vWlrrlIe.i.Snf-7t.0(A5"*AAGO:VC4-J5S?S3<!w2>>CJK}li
50 A. injection
1 tiJrfiL 50- ?BA
Mobilptota: A: vaiar B: tnaihenol Gradiant: tlm[raln] KB FlawtmUmln]
Sujf .: 1* -C
Example calibration curves and chromatograms | .:
In 40/60%H20/ACN
3l^ mL s V t B A <U
MS,S ] 160ng/mLt l
1 rig/fftL6-ZT8A
10-2 TBA, 10 eV
Fragmentation pattern for Telomer 5 Alcohols: - loss of 4 HFs (4 x 20) and CO (2S)
i ng/mL 6-2 TBA
- m - j - r j it 1 500 ni. Injection
1 rtjsftr.l.1-27BA
-
1ni.84T3A
1 fijjftrt. 6-2 TBA
Summary:
- detection and separation o f Telomer B Alcohols b y L C / M S / M S was demonstrated - linear calibration curves were obtained: fo r three examined T B A s; 0,5-100 ng/mL (50 //l-Injection):
and 05-1. rig/mL (5 0 0 ^ injieiettan) fo r samples prepared i n 50 /5 0 %water/methanol; - 5 0 ppt.LQQs a re achievable fo r examined T B A ^ iri aqueous m atrix by L C / M S/ M S with 50 0 fL
injection; - further validation o f L C / M S / M S method fo r T M s <n authentic m a trid M i? required;
Summary:
L C / M S methods f o r analysis o f 8 - 2 T B A weredesigned to monitor signal of deprotonated molecular ion
and acetate adduct;
aqueous samples of 8 -2 T B A can be qubntitdfiyieiy extracted with acetonitrile (1:2 W4fepiACN);: samples can also be extra cted with M T B E andi M T B E extract iryected a fte r 1;1G dilution with
aCetphitrile; ;
..
presented method allows: injection o f samples in 100% acetonitrile or 1:10 teffahydrofuran
(TfdE)/acet,onitpiie^
ability to analyze:8-2 T B A by L C / M S allows Simpliflaitron o f Sample preparation procedures and makeS: :
them compatible with th o se u se d fa r fluorinatedacids analysis;
ability to inject e xtra cts originating from d ifferent solvents broadens the applicability o f the method to
d iffe ren t sample types (e,g. reduction of matrix e ffe c ts for: samples extracted with M T B E or analysis
of polymers: samples: soluble in THF);
: finear calibration curves were obtained fo r 8-2: T B A rang/ngfraw 3 ng/mL.tolOiOOQng/mL;
sub^ng/mL L O Q f o r 8 -2 TBA: quantitation is achievable using L C / M S system (2.0 j/L injection);
Perfluorinated acids by L C /M S /M S
