Document Lgm3nMGbnJMXJYzyvNBXYZq7z

AR226-2042 WASHINGTON WORKS C-8 INDUSTRIAL HYGIENE A. J. Playtis, 6/30/99 P JB 003934 E ID 6 1 3 6 2 6 C -S IN BLOOD - HISTORICAL 1978 Informed by 3 M tha-t C-8 Is found in the blood of exposed workers and persists for a long time. 1979 C-8 found in blood of DuPont workers. . 1980 Workers with blood C-8 found to have normal liver function. '' 1981 Birth defects scare - additional sampling. rA 1982 Blood program continues on voluntary basis - no trends noted. ...... 1990 Formal review of blood data. 'nr. J "'> 1993 Journal Of Occupational Medicine study of 3M workers. ' 1993 No connection found between WW cancer cases ahd C-8 exposure. 1995 First 5-year "snapshot". 1996 No excess disease incidence found in 51 WW employees with highest C-8 blood levels. .) 1998-7 Follow-up from 1995 blood study. Zobb r'r?-i Js *v r 1 !6 ' s-, t rr -i> ' '.,1.0 r 5m ,. / 4 r?L - 1/. / .,7 P JB 003935 E ID 6 1 3 6 2 7 C - 8 DOCUMENT L IS T Liver Function Study Of Washington Works Employees Exposed To C-8. W. E. Fayerweathar, 1/28/81 Review Of Washington Works C-8 Data. Blood Data. H. A, Smith, 3/19/90 Personal Air Monitoring And Work Histories Of specific Cancer Cs s b s . A. J. Playtis, 11/15/93 . summary Of 1995 C-8 Blood Testing. A. J. Playtis, 5/7/96 C-8 Study. Y. L. Power, 8/5/96 - Washington Works Response to Bamirez/Reinhardt O.H. Review. A. J. Playtis, 12/12/96 C-8 industrial Hygiene Follow-up. A. J. Playtis, 12/18/96 Summary Of Special C-8 Sampling Project. J. Nichols, 8/16/97 P JB 003936 ED613628 1990 C-8 INDUSTRIAL HYSIEHE DATA REVIEW (HA Smith, JB Loschi avo, RD Lanyon, WE Crawley) CONCLUSIONS (Recognizing the data limitations) There is a correlation between blood and air C-8 levels that is confused by dermal exposure. Exposure at the AEL of 0.56 mpb would result in a blood level of about 3 ppm. Background blood level for the Teflon* area is between 0.1 and 0.5 ppi. Dermal exposure is the cause for higher blood levels. Half life for C-8 in blood is about A to 5 years. Annual blood testing is not useful and should be replaced by "snapshots" at longer intervals. P JB 003937 ED613629 1995 C-8 IN BLOOD "SNAPSHOT" PURPOSES ' Monitor the overall effectiveness of our C-8 industrial hygiene programs. Create and maintain a continuous data base for epidemiologic surveillance of our exposed population. Provide closure for issues raised by the 1990 data review. Honor employee requests for voluntary testing. TEST POPULATIONS Employees in C-8 jobs (82 of 140} Employees not in C-8 jobs with a previous result >3 ppm (9 of 12) Pensioners with a high previous result (9 of 19) Volunteers (18) P JB 003938 E ID 6 1 3 6 3 0 1995 C - 8 BLOOD STUDY CONCLUSIONS o AVERAGE BLOOD LEVELS FOR DIFFERENT JOBS RANGE FROM 0.5 TO 3.5 PPM 0 MOST JOB AVERAGE BLOOD LEVELS HAVE GONE DOWN FROM 19B9 TO 1995, PROBABLY DUE TO REDUCED SKIN CONTACT o NO ONE TESTED HAD A BLOOD LEVEL >5 PPM o TWO PEOPLE IN THE SAME JOB FOR MANY YEARS CAN HAVE VERY DIFFERENT BLOOD LEVELS O MECHANICS AVERAGE ABOUT 1 PPM 0 PENSIONER DATA INDICATES A BLOOD HALF-LIFE OF.ROUGHLY 4 YEARS, BUT WITH WIDE INDIVIDUAL VARIATION. 0 THE CORRELATION BETWEEN AIR LEVELS AND BLOOD LEVELS IS WEAK O BETTER DATA COULD CHANGE MANY OF THESE CONCLUSIONS PTB003939 E ID 6 1 3 6 3 1 TABLE 1 RESULTS SUMMARY - OPERATORS m 08PE 08PF 08PH 08PI Q8 PJ 08PM 1BPA 18PB 18PC 18PD I8 P1] 18PK DESCRIPTION autoclave polykettle dispersion FP finishing FP packout C- 8 dryer recovery FEP polykettle FEP extruder/oyen FEP wet finishing FEP packout PFA/FEP bead FEP safety/disp 1995 AVERAGE (n) 2.5 (6 ) 2.9 (7) 2 . 2 (2 ) 2 . 2 (5) 0.6 (5) 1.7 (2) 2.3 (4) 1.6 (5) 3.3 (2) 0.1 [3) 0.7 (2) 2 . 1 (2 ) 1989 AVERAGE (n) 4.7 (7) 4.0 (4) 3.2 (3) 2 . 0 (6 ) 0.5 (3) RESULTS SUMMARY - MECHANICS 58MC 58MD 58MG 6 8 MA 6 8 MB FP/disp/gran/TA general shift process EAI general shift FEP E M 1.4 (1) 1 . 1 (8 ) 0 . 8 (7) 1.1 (5) 0.9 (7) P JB 003940 E ID 6 1 3 6 3 2 tr&T.T? T.TFE RESULTS FROM PENSIONERS C8 DATE PPM 4/89 5.7 3/87 1.2 9/81 6.5 3/8 B 2.8 8/84 2.4 7/84 5.9 3/85 3.0 9/82 6.3 3/88 1.7 RET. DATE 4/91 6/92 4/85 12/92 4/85 12/81 4/85 12/82 12/93 DATE8PPM 3/95 4.3 3/95 1.1 3/95 1.1 3/95 2.2 3/95 .72 3/95 ,94 3/95 .14 3/95 .57 3/95 2.4 1/2 LIFE (YEARS) 9.7 22 3.9 6.5 5.7* 4.0* 2.3* 3.5* -- For * results, n= 4 average = 3.9 sigma = 1 . 4 using log n__ = -.301 t no tl/2 P JB 003941 E1D613633 WASHINGTON WORKS AIR SAMPLING RESULTS <10% AEL <50% AEL <100% AEL >100% AEL TOTAL 1994 40 14 3 0 57 PERSONAL SAMPLES 1 M 1996 1997 15 48 60 14 19 31 1 2 10 001 30 69 102 1998 50 18 9 0 77 1999 30 11 1 0 42 1994 43 AREA SAMPLES 1995 1996 26 29 1997 171 1998 40 1999* 18 "through 5/31 o PERS (DOHMS) system used to determine where personal samples are needed. o S12T used to determine sampling frequencies, usually 90, 180, or 360 days. o Area samples have support role, identifying locations where C-B levels are high. P JB 003942 E ID 6 1 3 6 3 4 PATH FORWARD Finish Data AnalysisEmployee Communication Site Industrial Hygiene Efforts Toxicology Work (Do we need a BEI?) Continue Annual Voluntary Testing Take Another Snapshot In 2000 P JB 003943 E ID 6 1 3 6 3 5 WASHINGTON WORKS C -B IN D U STR IA L HYGIENE - LOOKING FORWARD ONGOING SITE PROGRAMS o AIR MONITORING o BLOOD MONITORING o EPIDEMIOLOGY 0 CONTINUOUS IMPROVEMENT OF CONTROL MEASURES QUESTIONS TO BE ANSWERED o DO WE HAVE SUFFICIENT TOXICOLOGY DATA? o SHOULD WE DO ADDITIONAL MEDICAL SURVEILLANCE? o DO WE NEED A BEI? o W E WE SATISFIED WITH OUR CURRENT AEL? o SHOULD BLOOD TESTING BE MANDATORY? P JB 003944 E ID 6 1 3 6 3 6