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f t4 R _ 3-S 3<? 420 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations M za- Revised Page DuPont-5386 TRADE SECRET Study Title H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Revision No. 1 Volume 5 of 5 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100(1998) Author: Gregory S. Ladies, Ph.D., D.A.B.T. Original Completed on: December 3, 2001 Revision No. 1 Completed on: April 5, 2002 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 W ork Request Number:|(| Service Code Number:Q Sponsor Study Number^ Page 1281 of 1503 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX MM INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS Pi ADULTS AND F, ADULTS Company Sanitized. Does not contain TSCA CBI 1282 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 hd H 1 O INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS 0 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643148 643229 643218 643207 643280 643211 643197 643242 643251 643147 643276 643254 571.6 518.8 632.6 544.9 627.7 591.0 622.8 645.3 582.2 613.3 759.3 546.8 0.019 0.016 0.023 0.023 0.027 0.021 0.024 0.022 0.018 0.020 0.023 0.018 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - P1 ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-O 25 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643287 643188 643230 643170 643144 643277 643214 643166 643153 643177 643291 643167 643223 643233 643183 643219 643263 500.5 688.9 544.3 619.2 519.8 680.8 622.6 615.7 589.9 593.7 635.8 617.1 534.2 529.0 628.4 645.9 539.5 0.016 0.021 0.016 0.017 0.018 0.029 0.018 0.020 0.013 0.016 0.017 0.023 0.023 0.020 0.020 0.026 0.019 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 *0 < 1 o INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS 100 m g /kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643313 643146 643312 643199 643216 643245 643301 643200 643157 643238 643164 643154 643208 643190 549.8 624.4 554.9 564.1 555.0 501.8 604.8 616.4 603.9 535.4 639.8 460.3 425.2 564.9 0.026 0.028 0.012 0.022 0.023 0.018 0.018 0.024 0.030 0.027 0.019 0.020 0.018 0.023 Company Sanitized. Does not contain TSCA CBl 1285 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Pi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: VII-0 250 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643289 643171 643158 643249 643161 643248 643285 643274 643192 643222 643160 643191 643302 643317 456.0 628.2 639.7 583.9 587.8 407.7 498.3 527.3 613.3 542.6 509.0 541.5 547.9 497.4 0.027 0.028 0.043 0.014 0.030 0.018 0.016 0.024 0.025 0.025 0.018 0.024 0.030 0.025 Company Sanitized. Does not contain TSCA CBI 1286 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-O 0 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643459 643480 643363 643421 643419 643401 643455 643378 643447 643478 643386 377.8 330.8 379.1 286.3 402.9 324.0 331.8 376.7 365.9 339.1 354.3 0.019 0.019 0.017 0.014 0.016 0.020 0.027 0.024 0.023 0.012 0.021 Company Sanitized. Does not contain TSCA CBI 1287 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: IV-0 25 mg/kg/day 643399 643334 643464 643369 643490 643342 643438 643418 643325 643479 643376 643452 643475 643372 643400 643395 643457 342 .4 355 .0 391 .5 377 .9 353 .7 381 .8 352 .0 346,.4 405 ,.7 358 .6 366..9 375..0 388,.9 346..7 356 .0 350 .5 371 .1 0..021 0 .021 0 .024 0..016 0..020 0..022 0 .029 0 .017 0 .021 0 .027 0..018 0 ..020 0..022 0 ..018 0.,026 0 ..016 0..023 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-0 100 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643320 643428 643439 643353 643339 643337 643416 643427 643434 643349 643333 643460 367.8 380.6 363.0 360.9 353.0 381.7 341.5 329.2 360.8 365.2 346.8 360.0 0.019 0.018 0.024 0.021 0.016 0.017 0.024 0.016 0.026 0.018 0.025 0.019 Company Sanitized. Does not contain TSCA CBt 1289 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Px ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-0 250 mg/kg/day ANIMAL NUMBER FINAL BODY THYROID GLAND 643467 643443 643417 643413 643338 643335 643468 643440 643326 643365 643328 643449 345.4 259.3 306.4 283.6 357.6 362.4 319.3 390.6 361.5 380.5 312.4 377.1 0.025 0.013 0.013 0.028 0.026 0.018 0.027 0.024 0.025 0.024 0.019 0.019 Company Sanitized. Does not contain TSCA CB1 1290 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGi FINAL BODY AND ABSOLUTE ORGAN WEIGHTS GROUP: 1-1 - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND PROSTATE 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 329.2 446.1 387.8 407.7 407.3 362.9 396.7 352.3 353.4 407.4 389.7 400.4 361.8 14.069 20.638 16.432 16.834 17.318 17.748 18.285 16.343 16.544 20.000 19.329 18.551 15.250 2.789 3.502 3.105 3.384 3.355 3.455 3.555 2.889 3.145 3.767 3.141 3.562 3.030 0.023 0.021 0.013 0.020 0.015 0.021 0.019 0.020 0.021 0.010 0.020 0.023 0.020 0.314 0.616 0.474 0.412 0.508 0.520 0.494 0.487 0.279 0.526 0.692 0.409 0.255 1291 VN WEIGHTS - Fl ADULTS (grams) FROM MALE RATS DuPont-5386 SEMINAL VESICLES 1.001 1.574 0.963 1.186 1.377 1.186 1.537 1.047 0.929 1.180 1.288 1.258 1.070 TESTES 3.209 3.859 3.296 3.440 3.407 3.071 3.543 3.031 3.109 3.388 3.137 3.211 3.204 EPIDIDYMIDES 0.724 0.867 0.742 0.886 0.777 0.747 0.763 0.688 0.645 0.711 0.825 0.759 0.750 BRAIN 1.820 2.045 2.028 1.979 2.036 1.974 2.190 1.863 1.966 1.992 2.060 1.944 2.051 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP: III-l - 25 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID SEMINAL GLAND PROSTATE VESICLES TESTES 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 357.6 379.4 361.1 369.9 378.6 382.2 362.2 392.4 423.8 373.8 368.5 412.5 359.5 308.0 355.6 372.3 15.301 17.911 15.145 16.166 19.171 18.457 16.122 20.397 18.465 16.868 14.743 18.666 15.014 13.994 17.132 17.458 3.083 2.654 3.131 3.005 3.497 3.307 3.140 2.828 3.574 3.283 3.234 3.514 3.303 2.753 3.071 3.085 0.019 0.018 0.018 0.013 0.016 0.015 0.018 0.017 0.017 0.027 0.018 0.011 0.015 0.014 0.018 0.015 0.464 0.355 0.453 0.278 0.448 0.517 0.543 0.487 0.502 0.303 0.362 0.417 0.342 0.312 0.347 0.407 1.034 0.792 1.136 0.925 0.941 1.435 1.202 1.287 1.375 1.051 0.849 1.270 1.137 0.844 0.836 1.068 3.022 3.220 2.977 3.061 3.045 3.052 3.150 3.297 3.442 3.142 3.309 3.386 3.117 2.731 3.233 3.283 EPIDIDYMIDES 0.753 0.688 0.809 0.623 0.687 0.842 0.724 0.815 0.839 0.824 0.789 0.776 0.759 0.545 0.579 0.762 DuPont-5386 BRAIN 2.016 1.921 1.958 1.968 1.997 1.921 1.986 1.915 2.031 2.044 1.979 1.977 1.863 1.771 1.896 1.948 Company Sanitized. Does not contain TSCA CB! ! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL 30DY AND GRG FINAL BODY AND ABSOLUTE ORGAN WEIGHTS GROUP: V-l - 100 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND PROSTATE 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 337.6 366.8 330.2 418.8 422.4 367.0 366.3 382.6 386.4 379.5 380.4 375.6 11.604 16.720 13.625 18.190 22.330 16.428 16.743 19.704 17.954 17.448 18.392 16.066 3.114 3.256 2.826 3.674 3.652 2.918 3.479 3.053 3.115 2.912 3.415 2.976 0.022 0.018 0.015 0.015 0.017 0.012 0.006 0.013 0.016 0.021 0.016 0.013 0.298 0.448 0.248 0.325 0.365 0.308 0.341 0.349 0.389 0.309 0.531 0.509 1293 WEIGHTS -- Fi ADULTS (grams) FROM MALE RATS DuPont-5386 SEMINAL VESICLES 0.911 1.150 0.734 1.342 1.518 1.027 0.931 1.013 0.822 1.060 1.537 0.978 TESTES 3.211 3.375 3.058 3.265 3.079 3.168 3.568 3.154 3.132 2.851 3.781 2.997 EPIDIDYMIDES 0 ..696 0 ..774 0 ..690 0 ..753 0 ..794 0 ..782 0 ..728 0 ..726 0 ..729 0 ..659 0 ..824 0 ..707 BRAIN 2..138 1 ..987 1 .,839 1 ..938 1 ..935 1 ..931 1..832 1..935 1 ..868 2 .,074 2 .,153 1 .961 Company Sanfted. Doos con(an TSCA I H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGJ FINAL BODY AND ABSOLUTE ORGAN WEIGHTS GROUP: VII-1 - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND PROSTATE 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 351.2 362.1 470.3 346.4 367.7 338.8 336.0 344.6 327.9 361.9 352.9 364.7 16.054 15.376 19.170 14.994 15.545 15.621 17.685 14.558 15.967 15.602 15.802 16.070 3.249 3.175 3.832 3.064 3.271 2.961 3.348 3.205 3.314 3.513 2.753 3.348 0.018 0.018 0.022 0.014 0.026 0.014 0.018 0.021 0.022 0.020 0.010 0.018 0.459 0.495 0.667 0.470 0.494 0.385 0.280 0.362 0.315 0.300 0.275 0.368 1294 \N WEIGHTS - Fi ADULTS (grams) FROM MALE RATS 1 DuPont-5386 SEMINAL VESICLES 1.196 1.243 1.257 1.190 1.050 1.397 0.891 0.878 1.175 0.881 1.040 0.809 TESTES 2.631 3.093 4.208 2.779 2.796 2.566 3.210 3.334 2.955 2.877 2.801 3.217 EPIDIDYMIDES 0.728 0.643 0.857 0.659 0.663 0.715 0.684 0.717 0.676 0.655 0.629 0.603 BRAIN 1.999 2.024 2.030 1.994 1.933 1.897 1.852 1.929 2.084 1.990 2.078 1.922 omP*nySanitized. D e s notcontain TSCA CBf H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: II-l - 0 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 205.8 211.3 190.2 228.3 227.6 223.5 231.4 215.5 198.6 250.7 242.5 230.8 183.4 8.850 9.353 6.655 8.919 8.715 9.397 10.733 9.492 7.356 9.956 9.866 11.434 7.093 1.717 1.697 1.878 1.882 1.947 1.926 2.094 1.921 1.647 1.902 1.851 2.216 1.838 0.014 0.017 0.016 0.021 0.020 0.015 0.014 0.017 0.017 0.017 0.014 0.015 0.009 0.356 0.380 0.465 0.643 0.470 0.389 0.463 0.354 0.418 0.329 0.539 0.371 0.406 1.756 1.883 1.948 1.817 1.811 1.795 1.923 1.848 1.772 1.836 1.853 1.764 1.769 DuPont-5386 Company Sanitized. Does not contain TSCA CBl 1295 ) H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORC FINAL BODY AND ABSOLUTE ORGAN WEIGHTS GROUP: IV-1 - 25 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 209.6 234.8 217.0 239.8 230.5 286.7 261.3 208.0 278.6 203.7 171.9 238.3 215.0 201.8 201.1 212.4 232.7 9.907 9.838 9.399 9.492 10.921 12.292 10.396 7.671 12.246 7.800 6.831 12.077 8.056 8.438 7.467 9.262 10.916 1.905 2.037 2.149 2.030 2.146 2.596 2.179 1.943 2.421 1.945 1.695 2.125 1.856 1.756 1.697 1.858 2.303 0.015 0.012 0.011 0.016 0.017 0.011 0.016 0.020 0.013 0.013 0.020 0.013 0.018 0.019 0.008 0.013 0.018 0.428 0.421 0.263 0.854 0.631 0.410 0.510 0.545 0.570 0.488 0.580 0.357 0.401 0.324 0.341 0.398 0.477 1296 ;a n w e i g h t s - Fi a d u l t s (grams) FROM FEMALE RATS BRAIN 1.905 1.822 1.825 1.829 1.867 1.920 1.935 1.962 1.889 1.859 1.794 1.890 1.959 1.715 1.676 1.746 1.848 DuPont-5386 ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VI-1 - 100 mg/kg/day ANIMAL NUMBER 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 FINAL BODY 224.5 229.7 215.9 193.7 250.9 249.5 219.5 235.4 228.7 187.1 212.8 237.3 LIVER 8.740 8.193 8.707 8.560 12.280 11.101 10.179 10.573 10.055 7.631 9.426 9.675 KIDNEYS 2.052 2.029 1.999 2.236 2.284 2.028 2.326 1.981 2.470 1.603 1.832 1.774 THYROID GLAND 0.020 0.014 0.017 0.012 0.014 0.011 0.014 0.021 0.018 0.018 0.014 0.021 UTERUS 0.561 0.555 0.612 0.361 0.357 0.350 0.326 0.445 0.498 0.428 0.610 0.294 BRAIN 1.989 1.735 1.914 1.743 1.875 1.712 1.702 1.755 1.780 1.784 1.869 1.730 DuPont-5386 ompany Sanitized. Does not contain TSCA CB! 1297 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - Fi ADULTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP: VIII-1 - 250 mg/kg/day ANIMAL NUMBER FINAL BODY LIVER KIDNEYS THYROID GLAND UTERUS BRAIN 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 237.0 203.8 249.1 204.8 234.5 226.8 201.9 219.0 216.4 230.5 213.0 232.9 10.811 7.861 9.966 10.391 11.348 9.620 8.987 10.929 9.820 10.745 9.512 9.845 2.189 1.892 2.169 2.043 2.043 1.880 1.794 2.199 2.062 2.407 1.628 2.157 0.013 0.012 0.013 0.009 0.012 0.016 0.012 0.018 0.014 0.011 0.012 0.014 2.487 0.472 0.496 0.348 0.351 0.329 0.471 0.392 0.367 0.348 0.395 0.535 1.819 1.920 1.746 1.765 1.882 1.874 1.742 1.800 1.823 1.816 1.768 1.769 DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX NN INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS Company Sanitized. Does not contain TSCA CBI 1299 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - P, ADULTS EXPLANATORY NOTES Abbreviations AK = Accidentally killed FD = Found dead SD = Sacrificed by design Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643147 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643148 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS : NONE3 MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE a No gross observations were entered into the database at the time of necropsy. However, protocol tissues were saved and no abnormalities were detected when these tissues were re-examined. Company Sanitized. Does not contain TSCA C 1302 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg /kg /day ANIMAL #: 643155 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643163 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CompanySanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643176 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Comoany Sanitized. Does not contain TSCA CBI 1305 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643196 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi 1306 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643197 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi 1307 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643207 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1308 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643211 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1309 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg./kg/day ANIMAL #: 643218 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643229 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1311 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643239 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! 1312 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643242 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACB1 1313 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643251 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBl 1314 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643254 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643270 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBl 1316 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643271 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB 1317 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643276 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1318 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg /kg /day ANIMAL #: 643280 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does no! contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: 1-0 DOSE: 0 mg/kg/day ANIMAL #: 643284 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643144 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE company Sanitized. Does not contain TSCA CB1 1321 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643153 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C B r H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643166 DAYS ON TEST: 108 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBf 1323 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643167 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. D oe, not conlain t s c a CBI 1324 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643170 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1325 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643177 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643183 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACW 1327 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643184 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBt 1328 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643188 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643198 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643214 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE jompany Sanitized. Does not contain TSCA CB1 1331 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643219 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCUER H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643223 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643230 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643233 DAYS ON TEST: 109 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1335 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643261 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACB 1336 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643263 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB\ 1337 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643277 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643287 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA 1339 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: III-O DOSE: 25 mg/kg/day ANIMAL #: 643291 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1340 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643146 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBS H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643154 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643156 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643157 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643164 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCAEW 1345 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643182 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBS 1346 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643190 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1347 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643199 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1348 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643200 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCfcCW 1349 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643208 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1350 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643216 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE lompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643227 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1352 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643238 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1353 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643244 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643245 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain T SC A C 1355 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643255 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643267 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does not contain TSCACBl 1357 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643301 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE spany Sanitized. Does not contain TSCACBI 1358 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643312 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE mpany Sanitized. Does not contain TSCA CBI 1359 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V-0 DOSE: 100 mg/kg/day ANIMAL #: 643313 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643158 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1361 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643160 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643161 DAYS ON TEST: 107 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! 1363 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643171 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: V I I-0 DOSE: 250 mg/kg/day ANIMAL #: 643191 DAYS ON TEST: 109 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1365 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643192 DAYS ON TEST: 109 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643203 DAYS ON TEST: 109 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ,ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643222 DAYS ON TEST: 109 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643248 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643249 DAYS ON TEST: 107 MODE OF DEATH: GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBV 1370 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643274 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643278 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: PROSTATE - INFLAMMATION, SUBACUTE/CHRONIC, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIS, SEMINAL VESICLES, TESTIS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643281 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1373 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643282 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES, TESTES COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does no! contain T S C A C B l H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643285 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS : MICROSCOPIC CORRELATE selected lesions): EPIDIDYMIDES - LARGE, RIGHT; HEAD MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1375 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643289 DAYS ON TEST: 107 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643299 DAYS ON TEST: 108 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: EPIDIDYMIS, PROSTATE, SEMINAL VESICLES, TESTIS COAGULATING GLAND, THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643302 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS MALE RATS GROUP: VII-0 DOSE: 250 mg/kg/day ANIMAL #: 643317 DAYS ON TEST: 109 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643319 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: Company Sanitized. Does not contain TSCA CBI 1380 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pt ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643343 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1381 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643350 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE company Sanitized. Does not contain TSCA CBf 1382 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643352 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .ompany Sanitized. Does not contain TSCA CBI 1383 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643363 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1384 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643378 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1385 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643386 DAYS ON TEST: 126 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: II-O DOSE: 0 itig/kg/day ANIMAL # : 643393 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanilized. Does not contain TSCA CBI 1387 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643394 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643397 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): LIVER - DISCOLORATION, TAN, MOTTLED, LEFT MICROSCOPIC OBSERVATIONS : OTHER LIVER: NECROSIS, FOCAL, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1389 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643401 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE isOtnpsttySanitized. Does not contain TSCA CBI 1390 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643414 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBr 1391 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643419 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643420 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - ALOPECIA, PERINEUM; RIGHT FRONT LIMB MICROSCOPIC OBSERVATIONS : OTHER SKIN: NO ABNORMALITIES DETECTED THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does n t contain TSCA CBJ 1393 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj. ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643421 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1394 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643447 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1395 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643455 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643459 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized, Does not contain TSCA CBI 1397 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: II-O DOSE: 0 mg/kg/day ANIMAL #: 643478 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1398 Company Sanitized. Does not contain TSC& CW H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______________________DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg/day ANIMAL #: 643480 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643325 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643334 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBt 1401 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL # : 643342 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt 1402 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P] ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643369 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBI 1403 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643372 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1404 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643376 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P, ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643395 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACB\ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P- ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643399 DAYS ON TEST: 132 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643400 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt 1408 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643403 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1409 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643418 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643422 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACW 1411 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643438 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBl 1412 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P]_ ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643445 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643452 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1414 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643457 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TS C A CB! H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643464 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE {selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CM 1416 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643475 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE mpany Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P- ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643479 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE ompany Sanitized. Does not contain TSCACBI 1418 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P], ADULTS FEMALE RATS GROUP: IV-0 DOSE: 25 mg/kg/day ANIMAL #: 643490 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1419 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643320 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P: ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643331 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P; ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643333 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643337 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P3 ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643339 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643349 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1425 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P2 ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643353 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. D oes not contain TSCA CBl 1426 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643357 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE company Sanitized. Does not contain TSCACB 1427 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643385 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1428 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643407 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1429 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643416 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643427 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED: MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACSt 1431 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643428 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized.Does notcontainTSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643434 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE 1433 Company Sanitized. Does not contain TSCACW H -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P1 ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643439 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - PT ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL #: 643454 DAYS ON TEST: 99 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): SKIN - STAIN, RED, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P* ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643460 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1436 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643470 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB! 1437 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg/day ANIMAL #: 643473 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE :ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ?! ADULTS FEMALE RATS GROUP: V I -0 DOSE: 100 mg/kg/day ANIMAL # : 643 48 8 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: UTERUS - DILATATION, GLAND/LUMEN, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE .omp&ny Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643326 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain T S C A C W H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643328 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1441 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643335 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBl 1442 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643338 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643346 DAYS ON TEST: 91 MODE OF DEATH: AK GROSS OBSERVATIONS: MICROSCOPIC CORRELATE STOMACH SMALL INTESTINE SKIN (selected lesions): - DISTENDED WITH GAS, - DISTENDED WITH GAS, - STAIN, RED, FACE SEVERE SEVERE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACB! 1444 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643348 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1445 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643365 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized Does not contain TSCACBl 1446 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P^. ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643375 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1447 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643413 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACBl 1448 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL f: 643417 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1449 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643424 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: Company Sanitized. Does not contain TSCA CBI 1450 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pj ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day AliIMAL # : 643429 DAYS ON TEST: 106 MODE OF DEATH: FD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE KIDNEYS UTERUS SKIN (selected lesions): - DILATATION, BILATERAL, PELVIS - HEMORRHAGE - OBSTRUCTION, BODY; PLACENTA - STAIN, RED, VENTRAL BODY, FACE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi 1451 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643430 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1452 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643431 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS, VAGINA THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1453 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Pi ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643440 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 1454 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643443 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CW 1455 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - P-, ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643449 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1456 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643467 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI 1457 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS - Px ADULTS FEMALE RATS GROUP: VIII-0 DOSE: 250 mg/kg/day ANIMAL #: 643468 DAYS ON TEST: 125 MODE OF DEATH: SD GROSS OBSERVATIONS: MICROSCOPIC CORRELATE (selected lesions): NO ABNORMALITIES DETECTED MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCACW 1458 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX OO INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, PUPS Company Sanitized. Does not contain TSCA CBI 1459 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, PUPS EXPLANATORY NOTES Abbreviations FD = Found dead Company Sanitized. Does not contain TSCACSt 1460 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj PUPS DAM GROUP: II-O DOSE: 0 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 643455 M 647028 -21 FD NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CB\ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. PUPS DAM GROUP: IV-0 DOSE: 25 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 643376 M 647033 -21 FD 643400 M 647034 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED DuPont-5386 Company Sanitized. Does not contain TSCA CBt 1462 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj. PUPS DAM GROUP : VI-0 DOSE: 100 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE OBSERVATIONS 643320 M 647042 -21 FD F 647052 -21 FD 643439 M 647036 -21 FD 647037 -21 FD F 647056 -21 FD 647057 -21 FD 643331 M 647038 -21 FD 647039 -21 FD 647040 -21 FD 647041 -21 FD F 647058 -21 FD 647059 -21 FD 647060 -21 FD 647061 -21 FD 647062 -21 FD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED DuPont-5386 Company Sanitized. Does not contain TSCA CB\ 1463 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx PUPS DAM GROUP: VIII-0 DOSE: 250 MG/KG/DAY DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FA' OBSERVATIONS DuPont-5386 643326 M 647046 -21 FD 643365 M 647047 -21 FD 643375 M 647043 -21 FD 647044 -21 FD 647045 -21 FD F 647063 -21 FD 643429 F 647065 -21 FD 647066 -21 FD 647067 -21 FD U 647029 -21 FD 647030 -21 FD 647031 -21 FD 647032 -21 FD 647048 -21 FD 647049 -21 FD 647050 -21 FD 647051 -21 FD 647035 -21 FD 647053 -21 FD 647054 -21 FD 647055 -21 FD 647064 -21 FD STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED PERITONEAL CAVITY - CANNIBALIZED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE WHOLE BODY - AUTOLYSIS, SEVERE WHOLE BODY - AUTOLYSIS, SEVERE NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE WHOLE BODY - AUTOLYSIS, SEVERE NO ABNORMALITIES DETECTED PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE PUP APPEARS PREMATURE WHOLE BODY - AUTOLYSIS, SEVERE Company Sanitized. Does not contain TSCA CB1 1464 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS Company Sanitized. Does not contain TS C A C H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS EXPLANATORY NOTES Abbreviations SP = Sacrificed by design; necropsy performed Company Sanitized. Does not contain TSCA CBl 1466 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F-, WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: 1-1 DOSE:: 0 MG/KG/DAY OBSERVATIONS 647081 647082 647083 647084 647085 647086 647087 647088 647089 647090 647091 647092 647093 647094 647095 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 .ompany Sani,bed. Dosa noi conialo t s c a CUI 1467 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647096 647097 647098 647099 647100 647101 647102 647103 647104 647105 647106 647107 647108 647109 647110 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 ompany Sanitized. Does not contain TSCA CB1 1468 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Ft WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: 1-1 DOSE: 0 MG/KG/DAY OBSERVATIONS 647111 647112 647113 647114 647115 647116 647117 647118 647119 647120 647121 647122 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 company Sanitized. Does not contain TSCA CBI 1469 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F :. WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 647139 647140 647141 647142 647143 647144 647145 647146 647147 647148 647149 647150 647151 647152 647153 647154 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 647155 647156 647157 647158 647159 647160 647161 647162 647163 647164 647165 647166 647167 647168 647169 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - LARGE, LEFT KIDNEYS - SMALL, RIGHT; SEVERE NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: III-l DOSE: 25 MG/KG/DAY OBSERVATIONS 647170 647171 647172 647173 647174 647175 647176 647177 647178 647179 647180 647181 647182 647183 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F-! WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647196 647197 647198 647199 647200 647201 647202 647203 647204 647205 647206 647207 647208 647209 647210 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1473 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647211 647212 647213 647214 647215 647216 647217 647218 647219 647220 647221 647222 647223 647224 647225 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1474 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F5. WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS 647226 647227 647228 647229 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBi 1475 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647242 647243 647244 647245 647246 647247 647248 647249 647250 647251 647252 647253 647254 647255 647256 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCAK 1476 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Ft WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VII-1 DOSE:: 250 MG/KG/DAY OBSERVATIONS DuPont-5386 647257 647258 647259 647260 647261 647262 647263 647264 647265 647266 647267 647268 647269 647270 647271 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CEI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS MALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647272 647273 647274 647275 647276 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 647290 647291 647292 647293 647294 647295 647296 647297 647298 647299 647300 647301 647302 647303 647304 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1479 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - \ WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 647305 647306 647307 647308 647309 647310 647311 647312 647313 647314 647315 647316 647317 647318 647319 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: II-l DOSE: 0 MG/KG/DAY OBSERVATIONS 647320 647321 647322 647323 647324 647325 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCACB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647343 647344 647345 647346 647347 647348 647349 647350 647351 647352 647353 647354 647355 647356 647357 647358 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1482 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F:l WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS DuPont-5386 647359 647360 647361 647362 647363 647364 647365 647366 647367 647368 647369 647370 647371 647372 647373 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI 1483 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - FL WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647374 647375 647376 647377 647378 647379 647380 647381 647382 647383 647384 647385 647386 647387 647388 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBl 1484 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: IV-1 DOSE: 25 MG/KG/DAY OBSERVATIONS 647389 647390 647391 647392 647393 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fj WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS 647406 647407 647408 647409 647410 647411 647412 647413 647414 647415 647416 647417 647418 647419 647420 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI I486 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VI-1 DOSE: 100 MG/KG/DAY OBSERVATIONS 647421 647422 647423 647424 647425 647426 647427 647428 647429 647430 647431 647432 647433 647434 647435 1 SP 1 SP 1 ' SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1487 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS DuPont-5386 647448 647449 647450 647451 647452 647453 647454 647455 647456 647457 647458 647459 647460 647461 647462 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI 1488 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS DuPont-5386 647463 647464 647465 647466 647467 647468 647469 647470 647471 647472 647473 647474 647475 647476 647477 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CB 1489 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F: WEANLINGS FEMALE RATS ANIMAL DAYS NUMBER ON TEST FATE GROUP: VIII-1 DOSE: 250 MG/KG/DAY OBSERVATIONS 647478 647479 647480 647481 647482 647483 647484 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX QQ INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Ft ADULTS Company Sanitized. Does not contain TSCACW 1491 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F, ADULTS EXPLANATORY NOTES Abbreviations SD = Sacrificed by design Company Sanltfzed. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 647068 647069 647070 647071 647072 647073 647074 647075 647076 647077 647078 647079 647080 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, BILATERAL, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCACB1 1493 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS GROUP: III-l DOSE: 25 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 647123 647124 647125 647126 647127 647128 647129 647130 647131 647132 647133 647134 647135 647136 647137 647138 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS DuPont-5386 Company Sanitized. Does not contain TSCA CB1 1494 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS MALE RATS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH GROUP: V-l DOSE: 100 MG/KG/DAY OBSERVATIONS DuPont-5386 647184 647185 647186 647187 647188 647189 647190 647191 647192 647193 647194 647195 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, MINIMAL, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CB1 1495 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fi ADULTS MALE RATS GROUP : VII-1 DOSE: 250 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5386 647230 647231 647232 647233 647234 647235 647236 647237 647238 647239 647240 647241 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F3. ADULTS FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 647277 647278 647279 647280 647281 647282 647283 647284 647285 647286 647287 647288 647289 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBI 1497 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - Fx ADULTS FEMALE RATS GROUP: IV-1 DOSE: 25 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS 647326 647327 647328 647329 647330 647331 647332 647333 647334 647335 647336 647337 647338 647339 647340 647341 647342 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-5386 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS F, ADULTS FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5386 647394 647395 647396 647397 647398 647399 647400 647401 647402 647403 647404 647405 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, UNILATERAL, PELVIS KIDNEYS - DILATATION, RIGHT, PELVIS NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCACW 1499 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS - F-, ADULTS FEMALE RATS GROUP: VIII-1 DOSE: 250 MG/KG/DAY ANIMAL DAYS MODE OF NUMBER ON TEST DEATH OBSERVATIONS DuPont-5386 647436 647437 647438 647439 647440 647441 647442 647443 647444 647445 647446 647447 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBl 1500 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Revised Page DuPont-5386 APPENDIX RR REASON FOR REVISION NO. 1 Company SanMred. Does not contain TSCA CB' 1501 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations REASON FOR REVISION NO. 1 Revised Page DuPont-5386 The following changes were made to correct typographical errors. Pages 7 and 8 - Table of Contents, Removed subtitles that were inadvertently included for Tables 37-45. Page 66 - A. Biochemical Measurements, reference to tables was corrected to read "Tables 34-35." Pages 105-122 - Header, Corrected study title and DuPont number. Pages 131-174,317-481,629,970, and 1281 - Header, Corrected DuPont number. Page 156 - Table 34, defined by adding "# Statistically significant difference from control (p < 0.05) by Dunn's test." to the bottom o f the table. The following pages were revised or added to reflect these changes; Pages 1, 317, 629, 970, and 1281 - Title Pages for Volumes 1, 2, 3, 4, and 5, respectively were modified to include "Revision No. 1" and to update total number o f pages. Page 11 - Table of Contents was modified to include Appendix RR. Pages 1501-1503 - Appendix RR, Reason for Revision No. 1 was added. "Revised page" was added to the headers of all pages that were modified in this revision. The original pages were removed from the report and are maintained in the Medical Research file. Revision No. 1 Approved by: //Judith C. Stadler, Ph.D., D . A J . Staff Toxicologist Date Revision No. 1 Issued by Study Director Senior Research Scientist onipany Sanitized. Does not contain TSCA CB' 1502 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Dates o f Inspections: QUALITY ASSURANCE STATEMENT FOR REVISION NO. 1 Revision No. 1: 5-Apr-02 Revised Page DuPont-5386 Reported by: Quality Assurance Auditor OS-{\P~cX>o^ Date Company Sanitized. Does not contain 7SCA
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