Document LKZvpQL8wOr7yYKvk5ngdMbK5

AR226-2889 E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Clkton Road, Newark, Delaware 19711 Study Initiated/Completed 7/15/80 - 8/8/80 Material-Submitted by >pt. Jackson Lab ACUTE ORAL TEST IN RATS Procedure; The test material, as an aqueous solution, was administered by intragastric intubation to young adult male ChR-CD rats in single doses, 1 rat per dose level. Survivors were weighed and observed over a 14-day recovery period and then sacrificed. Results : Dose (mg/kg) Solution % ! 25,000*** 62 Mortality** S-14 d. Lethal Dose > 25,000 mg/kg 17,000*** 62 S-14 d. 11,000 62 S-14 d. 2,250 15 S-14 d. 670 15 S-14 d. Clinical Signs: Slight weight loss for 1 day after dosing at 17,000 and 25, mg/kg. 1 Com pany Sanitized. Does not contain T SC CBI Bg/kg of body weight, the maximum feasible dose. Slight Initial weight loss at the 2 highest dose levels was the only clinical sign observed. Purity: ** S - ( ) d. * Sacrificed ( ) days after dosing. *** Administered as a divided dose, 2 portions 15 minutes apart. Report by: Approved by: LH:jrg Study Director: 0. L. Dashiell t 13, 1980 Lonhie Hinckle Technician 'Company Sanitized. Does not contain TSCA CBI