Document LB2GqbEVmpbZmRBD0kKnxb8Q

1 MANUFACTURING CHEMISTS ASSOCIATION 1825 CONNECTICUT AVENUE, N.W. WASHINGTON, D. C. 20009 (202) 483-6126 April 17, 1978 TO: Vinyl Chloride Technical Panel Vinyl Chloride Research Coordinators SUBJECTS: Liver Angiosarcoma Registry, Dr, J. Stafford, Division Manager, Health and Environment Protection, Imperial Chemical Industries Limited, Plastics Division (Two Documents) Angiosarcoma of the Liver: An Epidemiologic Survey, by Judith Brady, et. al. Vinyl Chloride: A Case for the Use of Laboratory Bioassay in the Regulatory Control Procedure, by J. K. Wagoner and P. F. Infante Abstracts or Papers for the Seventh Annual Meeting of the Society of Toxicology, San Francisco, California, March 12-16, 1978: The Effect of Disulfiram on Vinyl Chloride Induced Carcinogenesis in Mice, by J. M. Winston, et. al. Gentlemen: Dr. Torkelson has requested that the subject documents be sent to the members of the Technical Panel and the Research Coordinators. Dr. Torkelson emphasizes once again Dr. Stafford's out standing work on the international compilation of data on angiosarcoma cases. To date. Dr. Stafford's registry is con sidered by Panel members to be far more complete than the information published by the National Institute for Occupational Safety and Health. ASI 000012281 Unfortunately, Dr. Stafford has not received answers to the questions on page one of his tabulation. Dr. Torkelson requests that Dr. Stafford's tables be distributed immediately to the Vinyl Chloride Monomer Sponsors with a request that they cooperate in every way possible with Dr. Stafford and his international effort. Sincerely, JTS:ec Enclosures U. T. Seawell Project Manager Vinyl Chloride Research ASX 000012282 ASX 0 0 0 0 1 2 2 8 3 i' by MCA for distribution to the Vinyl^jkiloride Technical Panel and Research Cuv^fi.nators, April 17, 1978, Mr. J. T. Sea^Rl - IMPERIAL CHEMICAL INDUSTRIES LIMITED PLASTICS DIVISION : WELWYN GARDEN CITY LIVER ANGIOSARCOHA CASES (REVIEW DATE - 15th MARCH 1978) Pages 1 2-3 4 5-6 7-8 9 10 11 12 13 14-17 18 2 Significant Changes US 23 - a few more that case : Company France 09 - ) France 10 - j new cases 3 Help Still Reouire Germany - (a) 1 If it is genuine may I have details please. (b) Is Case 06 (initials HH) a Hoechat case and was it at Oendorf? (c) 1What do I do with ease 03? Did Dynamit Nobel fill aerosol cans? If not, which conpany is this and whore? Should I remove OJ from our list? Italy USA What do I do with case 01? - (a) Is case 16 BPG? Louisville? Avon Lake? (b) " 17 " II " Still Alirs? (e) two entries in table. (d) Whose ease is 20? Details please. Also case 22. (e) More detail required on US 25 please, eg Coapany and Plant location. (f) Re case 23 (Gt. American Chemical) NIOSH sa; he died 06-04-73. but SPI told oe 06-04-76. Which is correct pleaBe? 'f ` ' . 1 : .> ICI PLASTICS DIVISION BESSEMER HOAD KELVIN GARDEN CITT LIVER Angloaarcoaa Casea - (Bariev Data:- 13th March 1978) A$I 000012284 1> wV) e o o o o M w w a> W ICI PLASTICS DIVISION BESSEMER ROAD WKLWTN GARDEN CITT LIVER Angiosarcoma Casas - (Review Cats * ill dataa uaa OK tjraUi Canada Sheet t fags 2 DAT - BOOTH - m> ** ill this Information should ba haId confidantial until It la published by Or Theriault of Laval University In (hiebae. Many of dates altered to fit KIOSK 31/3/77 Hat. 2 3 4 5 6 7 S 9 10 11 12 13 14 15 iMD KAMI OR DATE OP COMPANY TACTORT PIRST re DATE OP AGE AT TEARS OP TEARS OP DATE OP HISTOLOGICAL ESTIMATED OCCUPATION OTHER t NO IHITULS BIRTH EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE EXPOSURE DEATH CONFIRMATION EXPOSURE CAREER TO DIAGNOSIS LEVEL EUCHUQHTS 16 CITHER COMMENTS A SHAN NIGAN t 15-12-13 1944 1955 41 10 11 02-09-55 Tea 2 06-03-1A W3 1957 43 14 14 21-12-57 Tss 3 26-06-19 4 05-04-19 1941 1945 1962 1967 42 46 21 22 20 23-03-62 Taa 22 21-01-64 Tss 5 07-05-11 6 15.12-19 7 09-11-19 -------l1----------------e. 13-05-20 i 1944 I960 57 1947 1946 1971 1972 51 53 24 24 26 1961 1973 53 12 05 35-07-68 Taa 23 10-01-71 Taa 25 24-12-72 Tea 05 12-06-73 Taa Reactor Clamaar Operator polymeris ation Smoker Halntenanee, Operator, ellln-lcht, pipefitter Worked overtime Saoker Operator, foreman Worked overtime Ron-amoker Raaetor Cleaner Operator, foreman, aatercoolini unit Worked overtime Sasker Reactor Cleaner Water cooling unit Worked overtime Saoker Reactor Cleaner Maintenance Worked overtlne millwright Saoker Reector Cleaner Reector Cleener Machine Shop oper ator and poly unit Worked overtime Saoker lalntenance In plant 25 yearaj aaehine sbol Saoker ICI PLASTICS DIVISION BESSEMER ROAD WELWYN GARDEN CITT LIVER AngloMxcoat Cases - (RarieM Data: - 1Jth Hatch 1978) ASI 000012286 CO M O O O O rv> N> 00 N/ ICI PLASTICS DIVISION BESSfXER ROAD WEUflTN GARDEN CITT unrm ioglos&rcoaa Oum - ( R*l*w Dtt: 13th Hureh 1978) sa_l ICI PUSTICS DIVISION BESSEMER ROAD WELHTR GARDEN CITT LITER Aj^loa&rcoee Cun - (Review Dele:- 13 March 1978) Shoot . Page 5 2 3 4 56 78 9 10 11 12 13 14 15 .1' AND vne no KAMI OR INITIALS DATE OP BIRTH COMPARE FACTORY FIRST TC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF HISTOLOGICAL ESTIMATED DEATH CONFIRMATION EXPOSURE LEVEL OCCUPATION 01HER CAREER H3GHU0HTS 16 other cowmrrs et C2 03 15.04.24 RP tome*111' d 00.01,46 18,02.67 <3 03.06.11 PCUK Brignoud 06.07.59 15.01.75 63 06.01.20 RP St Tone 00.00.46 15.01.75 55 04 27.01.27 PCUK Brignood 19.10.49 16.01.76 49 05 29.01.3 PCUK Brignoud 10.01.65 13.05.76 38 : 06 14.04.34 PCUK Brlgnoud 01.03.50 12.00.76 42 - X, 21 19 19.02.67 Tee High "olyvorker 19 year* Ref. Rmvler et A1 Arch. Ml. Prof. 1 30 n 3 - nog 75 P. 171-177 16 12 24.01.75 Tee High Polyworker 10 yemre Ref. G. Bormaton et < "Hour*lie preeea edicele" 5 nor. 77 - p. 735 29 29 29.06.75 Tea High Polyworktr VCR Pro tef. Rety ot A1 10 yeere duction 16 Arch. Mai. Prof. yemre Com 1 37 n 6 Jain 76 pounding 2 p. 551 - 555 yemre 26 26 04.01.76 Tee High MkUob worker 8 yemre Auto- cleaner 10 yemre 11 11 13.05.76 Tee 10 13 11.09.76 Tee (mo sb (EIOSH ey* 17) aeye 12.09.76 High High Polyvorker 11 yemre Polyvorker 10 yemre _______________ Ref P Coudere et A1 "Semnine dee boplteus 10 Septeebre *76 Preriouely had hone pngloamreoea1* AOL prior to AS Ann.de Hal. Prof. 1 July *77. p 645 A 6 rVanco o Shc-jt 2 o o ICI PLASTICS DIVISION o BESSEMER ROAD N> WELUYH GARDEN CITT M CD ^0 LIVER Anglosureota Cosea - (Rsvleu Data:- 13 March 1978) 3 3 4 5 6 7 8 9 10 11 12 13 14 15 [ ADD CE NO KAHE OR INITIALS DATS OF BIRTH COMPANY FACTORY riRST vc EXPOSORS DATE OF DIAGNOSIS AOS AT DIASDOSIS YEARS 07 E2rOSU*IS TO DIAGNOSIS YEARS OF UTOSURE DATE OF DEATH HISTOLOGICAL COiffIKimOB ESTIMATED exposure LEVEL OCCUPATIOit OTHER CAREER tnoRustTrs 16 OTHER C0;:3RTS i*7 00.00.37 RP St AutiaD 91.07.50 Aftar 49 doath R10SB Day: 00.07.76 OP i 09 RI 0t.04.34 SOLVAT Tavaux 23.05.57 03.12.75 08,10,14 RP St Fona 10,01.48 26.04,76 42 62 26 19 28 T 24,05.15 HP St Fans 00.12.55 00.01.78 58 21 22 02.07.7< Tea 19 30.01.77 Ios 28 16.12.77 Yob 21 00.01.73 Toa High Plant forccm Died of aarticrcria Trail lirar lea1cm Tread aftar autopsy High High HAsh Pecker than poljvorker PolTrerlco- 10 75873 111 Operated 4.76 Tar tlon culphuria recornl cf turour Operator ald feo- fren llrar end died tory.atorc- oftor soeced surgical ScDBpsr ft operation for blllo goDornl brccshial flatula aorvlcas 'atla7B Cleaner Also In Wed cf puls-Otary raebanleol crbol?m 5 407 ongiceorir; after surgery Industry ! t 1__________ . ICI P1ASTICS DIVISION BESSEMER ROAD WELWYN GARDEN CITT LIVES Anglosarcoaa Cases . (Rarlew Cut*:- 13 fareh 197s) Geraany Sheet 1 pg 7 2 3 4 56 78 9 10 11 12 13 14 15 16 1 AND '.KZ NO KUO OR INITIALS DATS or BIRTH COMPANY FACTORY FIRST VC EXPOSURE DATE Or DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS Or EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER hichughts OTHER COMCNrS f-r or OA.O^.JO Dynanlt 'roiedorl 01.10.56 19.9.68 38 BA 26.07.31 Djxamit Voladorf 14. 10.57 25.9.70 -- 01 16.07.30 Dynanlt? 09.06.52 00.03.73 40 (39?) 43 04.09.30 Hanker Burg- 16.04.57 26.11.74 bauaen 44 m 01,01.32 Dynanlt 'roiadorf 16.12.62 00,00.75 NH 09.05.36 Hoeahat Gendorf? 02.04,60 00.12.73 (HIOSH ays 00,00.74) > tA 29.09.26 Watker tturg- '5.04.54 12.11.75 bauaan ' i ______ O 43 38 <9 I 00001229 12 12 25.01.6' Yaa (ElOSH) 13 12 14.12.7 Yaa (HIOSH) 21 21 10.10.73 Yaa (rrosH (moa) aaya 14) Polyvorker Polyvorker FUllng pesticide aerosol caw with VC 17 17 25.11.7' Yaa (NIOSB - bo ooaaant) 13 12 10.01.75 Yaa 13 (NICSH aaya 14) 05 (HIOSH aaya 03) 16.12.74 Yaa (Niosn) Polyvorkar A taap aatoelaamr Polyvorktr Polyvorker (NIOSH aaya ass latut factory chesist) 21 21 13.11.75 Th (tnosH aaya 12) Aatoeleaner 12 yra Fore du Taeh Dee 6 yrs _______________, ____ _______ mtea altarad to fit NIOSH 31/3/77 Lint and 1/78 * Dates altered to fit "S' w** Reported under nonpolyoerlaatIon workers In HIOSH lint of 3V3/77. Ia this earraet? Reported under nonpolynerlastIon workera la HIOSH llet of 3V3/77 A 1/78 _____ i ASI 000012291 ICI PLASTICS OmSION BESSEMER RQJU) WELWYN GARDEN CITY LIVER Angloearcoaa Cases - (Review Date:- 13 March 1978) Germany Sheet 2 Page fl 2 3 4 5 6 7 6 9 10 11 12 13 14 15 ! AND NUOt OR DATE OP COMPANY FACTORY FIRST VC DATE OP AGE AT YEARS OP YEARS OP DATE OP HISTOLOGICAL ESTIMATED OCCUPATION OTHER :f.:c l INITIALS BIRTH EXPOSURE DIAGNOSIS DIAGNOSIS EXPOSURE EXPOSURE DEATH CONFIRMATION EXPOSURE CAREER TO DIAGNOSIS LEVEL RKHUCHYS 16 OTHER COMMENTS ` (Y 7 7 79,10.17 7 7 19.04.54 1975 58 ? RI ' VJ 13.17.34 CVH Marl 00.02.61 (MIOSB eaye 2.12.59 but CUB Donfim 30.02.61) end '76 (KIOSH eay 1 16.6.76 bat CVH confirm end 76) 42 75.07.29 Linker 3urg- 10.10.55 78.C6.77 haueen 47 1 nc 29.12.36 CVfH brl 32.01.61 00.00.77 41 22 2t 25.12.75 Yea 77 r 7 15 (NIOSH eaye 17 bat CWH aonfIra 15) 13 Still [NIOSH oayi aim 15 but CVH confirm 13) (NIOSH aaya PM) Higi peak* Aotororker A cleaner 8 yre Neat Job 3m Control room 1 yr 22 22 78.06,77 Yea Kih 3 T*are lutoolare cleaner 19 yeare filter opera :or 16 10 07.03.77 Tee High pcaki 9 peart aotocleaner In NIOSH Hat of 16.2.77 awaiting details. These details given by NIOSH on 31.3*77. Whose oaen is tbia? Why have ve not heard of it? still Aim In Job A wan 179 cleaner with average 700 ppa exposure and oceaetonall 1000 . In Job B, 179 cleaner witb average 250 ppa. In Job C, 75 ppa average expoeure exporttree Identical to RE ease froa Marl ______________ ___________l ICI PLASTICS DIVISION BESSfcMER ROAD WELWYN GARDEN CITI LIVER Angiosarcoaa Casaa - (Review thte13 March 1978) * Should thie case be moved froe the liet? NIOSH have it on their eappleoentary Hat relating to nonpolyaerisation workers. JS 1/8/77 3 3 4 56 7B 9 10 11 12 13 14 15 :T AND crs no HUB OR INITIALS DATS OP CONRAN! PACTORT BIRTH PIRST VC DATE OP AGE AT OPOSURB DIAGNOSIS DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP HISTOLOGICAL ESTIMATED OCCUPATION OTHER DEATH CONFIRMATION EXPOSURE CAREER LEVEL HIGHLIGHTS 16 OTHER COMMENTS 1 15.06.34 OO.OO.65 19.04.71 36 06 03 16.04.71 ?Tes PVC Bag Extruder * Prinary tunour nay haw bean pericardium. Hot honogeneoua with other caeea. 1 13.11.29 Montedi Porto 00.00.57 13.12.73 43 15 06 30.12. 72 Tts Polyworker son Karghera ) 14.03.20 Solvay 00.01.53 10.07.75 55 23 21 10.07.75 Tes High Autocleaner 8 yra Autoclave operator 12 yra CO > . 1__________ ___________ 1 II 1> CO Pb.'za tQ M o * Could Japaneae PTC Aasoclatioa o o ICI FUSTICS Division bo asked to Consent on tbls table. o BESSEMER ROAD -* to WELWYN GARDEN CITT to >0 w LITER Angloaarcoea Cases - (Revlm Date:- 13 March 1978) 2 3 4 5 8 7 8 9 10 11 12 13 14 15 t AND Cl ID hake on nanus nm or COMPANY BIRTH FACTORY FIRST TC nPOSURB (UK OP DIAGNOSIS AOS AT DIAGNOSIS YEARS OP SZPOSURB TO DIAGNOSIS YEARS OP EXPOSURE DAK OP HISTOLOGICAL D&4TH CONFIRrlAnOI ESTIMATED EXPOSURE LEVEL ocemnoa OTHER CAREER HIGOUGHTS 16 OTHER COrtCTTTS Tomji MORI MITSUI TOATSU 01-08-32 NAGOYA 1951? /ttlOSH 1 |oo-CM-53J 21-08-75 /niosh \ f 21.08.74 \i 52 SHIZOO SATO SHKEO TAHAEA SUB COIL. HA00Y1 TRACTOR TO HITSU : TOATSU MITSUI rncciA 1953 TOATSU Hot *68 43 KAZUT0SH1 OHO MITSUI TOATSU NAGOYA Dm *6? 02.08,39 00,11.98 10,08.76 <7 37 13 yra auto- Japan Tlaae 25-10-75 often slave eleant r 22 22 24-10-75 YES 3000 PfM 1964-eaelgi sd / tnosH | and no jro - to dIffart it 1 do eomwny teotlre fork elnce b id Matures 111 health. until 1974 Rasetor cleaner 1964-1974 Pro-cancerous disorder of liver. Japan Tinea 15.10.75 16 14-01-69 Dm *67 Japan Tines 27-10-75 sons figure! uncertain - bad print) Japan Tinea 27-10-75 18 13 10.08.76 l ____ L_ _______ __ ICI PLASTICS DIVISION BESSBffiR ROAD WELWYN QARDEM CITT LIVQl Auglosarcona Caaes - (Rariotf Ehto;- 13 Nvob 1970) 11 3 3 4 5 6 7 8 9 10 it 12 13 14 15 I AND :<CE KO HUS OR UOTIALS DATS OP BIRTH COUPAH? FACTOR! FIRST VC DATE OP AOS AT EXPOSURE DUOKOSIS DIAGNOSIS TEARS OP EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE OP HISTOLOGICAL DEATH CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HffiHUDHTS 16 OTHER COHOTTS AH 23.12.15 Norsk Itoroym 00.03.50 20.12.71 56 Hydro 22 21 M.01.72 Too High Formas I Aatoo Lar Superrloor Conflraod by Dr Ihila-Ennwea of n ASI 000012294 L______ </> M o r>^o <2 o o O 1CI PLASTICS DIVISION BBSSHER ROAD K> WEU/YN GALOSH CITY vO tn LIvlH Aa^ioearcoca Cages - (Rovieu Data:- 13 March 1978) 2 3 4 5 6 7 8 9 10 11 12 13 14 15 ' AND rji eo wm or IRITTALS DATE OP BIRTH COKPAJfT FACTORY PTRST VC npostmi DATS or Dttorcosxs AGE AT DLCCIDSIS YEARS 0? TO DlfcGlSSIS HEMS OF Ezrasoai DATE 0? HISTOLOGICAL CilTH coHFmtmoiJ ESTIMATED EXPOSURE CCCOFATKEI OTHER CAREER irnn.mnrs 16 OTHER COCCXITS 1 m 23.06.27 Keaanord htndcral] 14.08.51 20.10.70 43 1 BL 27.11.11 Kensnord iuademll 00.01.45 00.08.72 61 19 27 HE 10.06.10 Kes&nord SuadOTaU 00.05.47 18.03.76 65 29 t 1L 16.11.14 Kccanard 3und3TulI 8* 12.C5.77 64 31 18 20,10.70 27 16.00.72 Tea Tea 21 19.03.7s Tu 31 12.Co.77 Tea Polyverker VCH production High Polyworker Hich 19*6-1958 poJjnerieat; HI wrier (12 j rs) 5 19:8-1777 rwranll) ' rsl 'nit ttr Blocqolnt recarbore hin ea polyrerisation worker rad paracnalljr pilling jii onecaseleas r?oa tha PTC works In first 12 yosra of mployrent tad teoa hea7ily erpoeed. li ISC-1, liver cArrrrliij cccrosla iirsnoced. Pats conflresd In Pr 0 Pjrtn letter 10.0,77 to CEPIC ___ 1 > ) ICI PLASTICS DIVISION BKSSLMEU ROAD UBUnm GARDEN C1TT LITXR Anglosarco** Caaaa - (ttavlav Oit*:-' 13 Kuh 1978) py> J3 2 3 4 5 6 7 0 9 10 11 12 13 14 15 T AND MANX OR DATE OF COMPART FACTORT FIRST VC date or AOX AT tears or TEARS Or DATE OP HISTOLOGICAL ESTIMATED OCCUPATION OTHER Cl NO INITIALS BIRT8 EXPOSURE DIAGNOSIS DU0N0SI8 EXPOSURE EXPOSURE DEATH CONFIRMATION EXPOSURE CAREER TO DIAGNOSIS LEVEL HIGHUDHTS 16 OTHER cowan >1 WJ 30.04.01 ICI Hlllboua > 04.04.44 03.12.72 71 (tat * Collin' popn np 23.12.72) 38 22 >3.12.72 (fox A lollln npor aaj 1 0.12.72] 500 pf 1944-7 TCM 1947-8 Driar 1948-61 Autoelara operator 1961-66 Erin ? BJV 03.06.37 BP Barry 00.03.66 00.12.74 37 03 3.5 34.12.74 Tea Hib Autoclar* 0 lunar 3> C0 >-f c> c c o M M IK) O O Expoaur* lialtad to 2/66 - 9/69 NIOSH are atlU quoting Cut 03 fro* 10C0 hlb boa baa* diaoooat.d la tha 01 I0C0 apread aany polyner* Including PTC onto fabrlea. C> O usa O o SHEET f o> 10 ici pustxcs Division 10 SESSHUS ROAD UK syetee of datee WIMYH OAflDEE CITT OAT . MOUTH . mil UTO IngloiinHi Cum - (Rorlev Date:- 13 throb 1978) 2 3 4 5 6 7 8 9 10 11 12 13 14 15 AHD hams on UTS OP COCtPANT PACTOHT met vc SATE OP AOS AT UHTIALS surra EXPOSOBS DIAGNOSIS DIAGNOSIS reus or BEPOSURB ISADS or OATS OP HISTOLOGICAL ESTIMATED cccmnou EXPOSURE BOTH COKTHBUTIOi SXPOSURX mm CAREER to DliOBOSIS LEVEL HIDHLXDHT3 Pto* 14 16 OTHER COMMITS EMIL PARK 17-10-23 BTO LouIstU 09-12-41 03-03-73 49 9-00-33 are LooiarU. 15.11.55 00-05-70 37 25.05.15 15-01.34 BTO ER 25-01-12 BTO HAT AUSTH 23J1.M VO JOKES? Loolull 28.11.4! 19-12-73 Loolull: 06-07-51 19-0*47 Uralsvil 19-06-44 09-04-64 17-01-6: 00-02-74 58 43 52 45 atiRLIS T SMART tJCC S Charle 27.08.44 00-00-68 ston 45 24 21 13-03-73 TES 14 13 17-09-71 TES (BIOSH a IT* 28.09.71 ) 28 28 19-12-73 TES 15 15 >7-01-68 TES 20 20 >9*04-64 ns 12 12 4-07-75 TES 24 17 3-03-68 ns OS Air fore* Rolling Stem Art Ref 1 KT Acd of So Syp Ref 1 Also Hloek JAMA 1/7/74 p53 Ref 1 Ref 1 Ref 1 Ref 1 a Louisville Tim 23/7/75 Retired April 197 Ref 1 n $I 0r# ? 0 __ 06-05-?0 Goodyear NUfut 07-10-46 00-08-61 41 15 15 19-08-61 TES Ref 1 ____ ______ A- ________ ICI PLASTICS DIVISION BESSEMER ROAD visum oardeu cm LITER Aqgloaareoca Cassa - (Review Data:- 13 Mu^h 1978) US* SHEET 2 UK Systta of dat.s OAT - MONTH . TEAR Page is 2 34 56 78 9 10 11 12 13 14 15 I AND CK HO NAME OH INITIALS OATS or BIRTH company FACTORY nfiST TC QtFOSDDS un or DU0E0SI3 AOS AT DLAGHOSIS TEARS OF E2P0S0R3 TO DUOCOSTS TEARS OF EXPOSURE HATE 07 E2STH K1STOLOQICAL comiimnon ESTIMATED EXPOSURE um 0CCUP1TI03 OTHER CAREER HIGH1JDHTS 16 other comm \ RAYMOND 08-11-31 HR) Unilsrll 28.05/5 01-03-74 43 GETTLE- rimm? \ 16-08-13 Goodyear Ifiagara 12-06-51 00-05-68 55 27-05-09 Goodyear Niagara 14-10-46 00-03-70 61 t 17.11.10 rirootot: Pottato-.r. , 13-OM5 02-05-69 50 1 tlCHARO 01-12-21 occ S Charle- t1.12.-1r 00-05-74 5? 3WAR0 a ton 'i 1 > ! X> a> t-i ct ct c> c> (-1 7^ WN) v0O0 04-11-2? BTC? 06-05-31 BFC? 00-05-51 00-00-69 41 23-06-55 11-10-74 43 29 1 1 17 23 20 32 19 19 24 11-03-75 TES 17 10-05-68 TES 23 16-03-70 TES 19 J2-05-69 TES 26 17-04-74 TES 0* 27-03-69 TES 19 ILIYE? TES 2000 ppm Raf 1 has wrong flgurea ra first exporare. Loulsrills Tims 29-10-74, 12-3-75, 10-3-76 Raf 1 Raf 1 Raf 1 2000 ppm Charleston Dally Mall 21/7/75 Dablotus fabrication cate Dubious fabrication cast 1951-4 VCH PolyreriaetloD Proa 1954 onwards in Aray and other eervica. 16-50-Arcor Tabla 4 In Wagon,r Testimony to OS Saoata. ___________ 1 CO M o o USA teSS_J oo * UK ayataa of dataa Sheat 1 M DAT - KOKTH - TEAS tNo) >0 ICI PLASTICS DIVISION BESSEMER ROAD \0 WELWYN GARDEI CITT LITER Angioaarcoaa Caaaa - (Rarlaw Data:- 13 Kareh 1978) 3 3 4 5 6 7 8 9 10 11 12 13 14 15 r AMD HUE OR DATE OP COMPART TACTORT PIRST TO DATE OP AGE AT TEARS OP TEARS OP DATE OP KISTOLOGICAL ESTIMATED occmnoa OTHER xt m INITIALS BIRTH exposure DIAGNOSIS DIAGNOSIS EKPOSORE EXPOSURE DEATH COHPIBHATIOM EXPOSURE CAREER TO DIAGNOSIS LEVEL nrnm.TT.HTS 16 OTHER COMOrrS 1 10 la thia Char11a Arthur? 33-04-38 la tbla 8307 la thia Am Laka 15.09.54 00-00-75 ---- 19 TIRGIL 00-00-15 CHRISTIAN UCC S Charla- 0-00-43 19-06-75 atoa 46 60 30 31.08.17 31 CHESTER 03.09.09 DCC HDKLE 00.00.55 30-01-76 S Charla- 0Q.13.4i wurly1977 atoa 5 67 33 33 t 187 :harlik ARTHUR 03-10-33 la thU BIG? la thia 11.07.47 10th Loalarll] letla? 00-00-33 H tear1 fttfltbar 08.09.58 taso* 33-07-38 BIG tvoauu 00-01-76 06.04.73 00-03-75 52 50 47 31 33 31 30 39 15 31 ___ 13 03-11-75 Taa 33 6-4-76 Tm (lataat BIOSH ae; s A LITE} 18 30-01-76 Taa 33 03-01-77 Taa 3000 ppm 38 04-13-76 Taa 14 96-04-76 Taa 13 75 13 yoara AUTO- RAPT CLEAHEH 8 yra on TTRE STORE ESTOL PLAS - ICISER ADD CARDOSET Willlusport San Gasatta 31 Jana 1975 Cbarlaaton telly Mall 21/7/75. 38 yra with UCC at SC Ratlrad Fsva Raleaaa 33-3-77 Rollins Stoaa fefaalaa 15/1/76 ICI PLASTICS DIVISIOM BESSEMER ROAD WBUfTN GARDEN CITT LITER IngloNfcm Casts - (Rarlev Data:- 13 Hareh 1978) osi Staeat 4 --------- 17 < 2 3 4 5 6 7 B 9 10 11 12 13 14 15 1 ADD :<as MO HAKE OR 1RITULS DATE OP BIRTH COMPACT FACTORT FIRST 1C EXPOSURE DATE OP DIAGNOSIS AOE AT DIAGNOSIS TEARS OP EXPOSURE TO DIAGNOSIS TEARS OP EXPOSURE DATE Or HISTOLOGICAL DEATH CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATIOH OTHER CAREER HIGHUDBTS 16 onus comootts a 22? BFO Louitrll to 10 24-01-76 * Cfcarlaa 17*05.17 00c South 1939 27.05.77 60 Edward Charlart m Haora 1 ASI 000012300 1 1 ' 3> ! CO IM O O O O ' ' N> W O O 1 07.08.10 ? ? 00.02.47 10.03.77 67 2B ALIVE - Lovirrlllt Tints 26-1-76. Said to ba 10th AS rletla at Bal tana factory of aboa ban 4U to far. 3* 247 27.05.77 Taa Madina to 1941-45 1937-39 N M Vbaaltr lattar af (MIOSH High for non-aolrant ma off 18/8/77 to J Stafford wpa 26) 24 JfNTi Tlnyl ratio and co flm dttalla. unit and laboarar Dispart Ion rinjrl raaln unit flrat aa flttar balpar, tha: ahift atllity eu 1939-41 ay Ian baan sxpotsd aa raaciar alaanar 1943 baeaa ahift fltt nr 1946 baaaa 1 shift-at11ity 1 26.4.1965 plojratnt was tomint td 30 20 10.03.71 Tas I> ifl PcKt 18 o o o o ICI PLASTICS Dmsxos M BESSEEl ROAD to u> welutn amm cm o LIUS Ao^iocaroou Cases - (tUviw fate:- 13 llareh 1978) 2 3 4 5 6 7 0 9 10 11 13 13 14 15 1 1HD JCX CO UH3 on inmiLS MTS CP BIRTH co:ifai.t FACTORY FIRST ro CIF0S02C cm o? DUOFOSIS ACC A? D2LQi:0SI3 irxs o? TO DIIGI.OSJS YZATJJ 0? ... hFJSUlJ DATS OF EEiSTB laSTOLOOICAL coiffiRiiinou ESTEUTED nzposuss LEvSL CCiTTUTHn OTHIH CAREER mcHuntrrs 16 other corrsETa Uri* 1 f JujO 05.04,14 TinU Jr^a 15.11.31 Tinll Split Split 00.00.53 08.04.73 00.00.50 12.07.73 59 43 30 30 08.04.73 Yes 23 18 12.07.73 Tea Copied by MCA for distribution to the Vinyl chloride 'technical Panel and Research Coordinators, April 17, 1978, Mr. J. T. Seawell From To J Stafford Division Manager Health t Eovironaont Protection Welwyn See Circulation Uat Attached tci Pintle* Dtim*on Beteemer Rood Welwyn Gerden City Herti AL7 ihd Telephone Welwyn Gerden 33400 (STD 07073) STD code from London arei 96 Telex 264251 Coplet to Your re* Our ref JS/ERA DS0-107 Tel ext 3162 Dele 16 March 1978 A5L CASES With mj 13th March 1978 renew of the ASL ease*, say 1 plead for help. I have been reviaing these tables at regular intervals hut as handicapped by lack of response on none of the questions I raise. Will yon please check through your coopany county esses snd 1st et hare ootss of nisinforaation and also fill oe in on the blank spaces. So far as I can see the AS1, esses in the VCM/PVC industry are distributed: USA - 23 ftfr**4* Geroany - 10 - 10 Pranca - 10 Sweden -4 Italy -2 OK - 2 Japan lugoslaTla -2 -2 Chechoslovakia - 2 Norway Belgium -i -1 69 J Stafford *Sl 0012302 ASX 000012303 Liver Angiosarcoma Cases Circulations Dr G Pddl Dr D P Duffield Dr V G F Adana Dr D Winter Mr G J Sleddon/Mr A W Barnea Dr D W Pleater Mr W Adana - Visatex Mr P Sharrock - BP Mr R Harda - B1P Dr B W Duck - BP Mr T L Phillips BP Mr B M F Huteheeaon - CIA Mr A S Garnett - CEFIC Mr H Vallender CIA Dr W Freiealeben - Hacker Dr I de Baer - Shall Mr J C Thonaa - Rhone-Pouleoc Dr T Garlands - Montedison Mr M Bonncfoy - Solvoy Dr B Liat * Lanza Mr P G Claua - APME Dr J Kannuller * Shell Mr C Sjoelin Kenonnrd Mr C Rongnes - Norsk Hydro Dr P Praefke - CWH Mr H fininger - VXD Mr P de Voogd - Shell Dr I Lloyd-Jonea - BP Dr G Riley - Hillhouae Aaaiatast Works Manager Dr T W Beat - Mlllbask Dr G Norerose - Everberg Mr C d'Haenena - APME Dr T B Torkelnon - Dov Mr J lavrenee - SPI Mr N Wheeler - OCC Dr A Roes Adana - Air Prodncta Dr Walter D Harris - Dniroyal Inc. Dr D Douglas - WAS Dr P Baxter - WAS Dr J Stafford (6) JS/ERA/DSO-107 13 March 1978