Document KJY4voqJmdmYrzdzrqwxnx006

r 3M General Offices AR226-1897 3M Center St. Paul. MN 55144-1000 651 733 1110 Mi^ A 3M September 24, 20Q& SI" By Hand Delivery 169p. Document Processing Center (7407) Office of Pollution, Prevention and Toxics U.S. Environmental Protection Agency 1200 Pennsylvania Avenue, N. W. Washington, DC 20460 Attention: Section 8(e) Coordinator Re: TSCA Section 8(e) Submissions Dear Sir/Madam: 3M Company ("3M") requests that EPA place the attached studies in the TSCA Section 8(e) docket. W e have included a master index for these studies identifying the study title, test substance and CAS number. A Confidential Business Information (CBI) version of this index and the studies also is being submitted today pursuant to EPA procedures. 3M has not provided CBI substantiation with this submission, but would be willing to do so at the Agency's request. 3M has concluded that data in these studies may not be, strictly speaking, "corroborative" of previously reported or published information as defined in EPA's reporting guidance or otherwise potentially may warrant 8(e) submission based on EPA's reporting guidance. 3M appreciates EPA's attention to this matter. Please contact the undersigned if you have any questions or require further information regarding this submission. Very truly yours, llllliilllHIIIliilllllllllllillllll! 8 EHQ - 0 4 i 584 S f\ld L iA ,u K ^ . f a L i0[ Dr. Katherine E. Reed, Ph.D C=;> Staff Vice President ^r n Environmental Technology and Safety j h f f l Services o (651)778-4331 kereed@mmm.com 88040000367 880 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) Primary Eye Irritation Study - Rabbits l 3l 20% solids (Ethomeen S/12 1.0M with diethyl 3 sulfate 0.94M); 80% water [Ethomeen S/12 = R- Guinea Pig Contact Dermal N(Et)+(C2H40H)2 where R=C18 with 1-2 Irritation/Sensitization double bondsl 20% (61791-24-0 with 64-67-5); 80% 7732-18-5 Primary Eye Irritation Study - Rabbits Butanoic acid, heptafluoro-, calcium salt 2366-98-5 Acute Oral Toxicity Screen with T- 2712CoC in Albino Rabbits perfluorohexanoic acid 307-24-4 Primary Skin Irritation Test with T- 2725Ec (Repeat Application) in Albino Rabbits l Acute Ocular Irritation Test with T- 3t 3 2725Ec in Albino Rabbits [ Sensitization Study with T-2741AC 3l 3 in Albino Guinea Pigs t 3t Oral Rangefinder Study of T-3140BS 1-[3'-(perfluorooctanesu!fonate) anilino amide]-2 3 in Pregnant Rats potassium 3,4,5,6-tetrachlorophthalate 80% 1-[3'-(perfluorooctanesulfonate) anilino 57589-85-2 amide]-2-potassium 3,4,5,6- Oral Rangefinder Study of T-3139BS tetrachlorophthalate; 5% C7 homolog; 5% C5 80% 57589-85-2; 5% 68541-01-5 ; 5% 68541-02-6; in Pregnant Rats homolog; 5% C4 homolog; 5% C6 homolog 5% 68568-54-7; 5% 68815-72-5 Acute Occular Irritation Test with T- perfluoroethylcyclohexylsulfonic acid diethanol 2997CoC in Albino Rabbits amine salt salt of 133201-07-7 and 111-42-2 Sensitization Study with T-3386 in Albino Guinea Pigs [ In Vitro Microbiological Mutagenicity 1[ 3 Assays of 3M Company's Compound T-3411 I_________________________________ )______ 1_________________________________ 1 1 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) 68% poly(oxy-1,2-ethanediyl), alpha-[2- [ethyl[(heptanedecafluorooctyl)sulfonyljamino]et hylj-omega-hydroxy-; 12% polethylene glycol; 7% water; 4.86% poly(oxy-1.2-ethanediyl), alpha-[2- [ethyl[{pentadecafluoroheptyl)sulfonyl]amino]eth yl]-omega-hydroxy-; 4% residual organic fluorochemical; 3% heptadecafluoro-1- octanesulfonic acid; 0.81% poly(oxy-1,2- ethanediyl), alpha-[2- [ethyl[(undecafluoropentyl)sulfonyl]amino]ethyl]- omega-hydroxy-; 0.3% 1,4-dioxane; 0.2% n- 68% 29117-08-6; 12% 25322-68-3; 7% 7732-18-5; ethylperfluorooctanesulfonamidoethyl alcohol; 4.86% 56372-23-7; 4.05% 68298-79-3; 3.24% Acute Oral Toxicity Screen with T- 0.03% linear n-ethyl 68298-81-7; 3% 1763-23-1; 0.81% 68298-80-6; 3448 in Albino Rats perfluorooctanesulfonamide 0.3% 123-91-1; 0.2% 1691-99-2; 0.03% 4151-50-2 ]n Vitro Microbiological Mutagenicity Assays of 3M 0 0 0 1 (3 3 0 /8 Compound T-3516 l ............ Acute Dermal Toxicity Study with T- _. I [ ............ I 3451 in Albino Rabbits C 8 F 1 7S 0 2N (C H 3).N a Unknown Acute Oral Toxicity - Method, Summary, Pathology; Primary Dermal Irritation - Method, Summary; Primary Eye Irritation - Method. Summary; Guinea Pig Maximization - Method, Summary i Acute Oral Toxicity - Method, ] [_ _ ] Summary, Pathology; Primary Dermal Irritation - Method, Summary; Primary Eye Irritation - Method, Summary; [ I .[ I Dermal Sensitization Study in [ lt 1 Guinea Pigs, Maximization Test - Method, Summary 4 Hour Acute Aerosol Inhalation [ t l I ........ ] I_ I 1 Toxicity Study with T-3825 in Rats t Primary Eye Irritaiton/Corrosion 1l ] Study in Rabbits 4-Hour Acute Aerosol Inhalation [ 1I ] Toxicity Study with T-3825 in Rats I_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 1_ _ _ _ I_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 1_ _ _ _ _ _ _ 2 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) T-3820: Acule Inhalation Toxicity T-3821: Acute Inhalation Toxicity Test T-3845 Acute Inhalation Toxicity Test Evaluation of the Acute Inhalation Toxicity of T-3920 in the Rat Primary Eye Irritation Study in Rabbits - Method, Summary Acute Oral Toxicity Study in Rats (OECD Guidelines) Acute Inhalation Toxicity Study with T-4129 in the Rat Acute Inhalation Toxicity Study with T-4130in theR at Acute Oral Toxicity Study in Rats; Acute Dermal Irritation Study in Rabbits; Acute Eye Irritation Study in Rabbits Dermal Sensitization Study in Guinea Pigs - Maximization Test I heptafluorobutyryl chloride ..........I . I ...............................3..............Decanoic acid, nonadecafluoro-, ammonium salt 95% ammonium perfluorodecanoate; 5% ammonium periluorooctanoate [ ............................. ] ......... i3 (3 [1 t 375-16-6 (. 3108-42-7 5% 3825-26-1 ( L l l ........................... 1 3 3 3 3 1 . Mutagenicity Test on T- 4413 { J Mouse Lymphoma Forward Mutation Assay with Duplicate Cultures 3 Acute Inhalation Toxicity Study with 1t 1 T-4354 in the Rat l Primary Dermal Irritation/Corrosion 3 [_ 1 Study in Rabbits Acute Inhalation Toxicity Study in t 1[ 1 the Rat with T-4397 Primary Eye Irritation/Corrosion [ 1l 1 Study of T-5261 in Rabbits lithium tetrafluoroethane-1,2-disulfonimide Unknown Acute Inhalation Toxicity Evaluation on T-5231 in Rats 4-Hour, Acute Inhalation Toxicity t 3l 3 Study with T-5305 in Rats 4-Hour, Acute Inhalation Toxicity I 3 [...... 3 Study (Limit Test) with T-5343.1 in Rats I_________________________________ l______ I _________________________________ ]_________ N3 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) 4-Hour, Acute Inhalation Toxicity Study With T-5306 in Rats 4-Hour, Acute Inhalation Toxicity [ 1[ 3 Study (Limit Test) with T-5357.1 Acute Dermal Toxicity Study of T- l 1 ... [ 3 4201 in Rabbits Lithium Bis(Trifluoromethanesulfonyl)imide 90076-65-6 SubAcute 28-Day Oral Toxicity with T-2816 by Daily Gavage in the Rat Followed by a 14 Day Recovery Period 1 Subacute 28-Day Oral Toxicity with 11 1 T-2816 by Daily Gavage in the Rat Followed by a 14-Day Recovery Period [ Acute Inhalation Toxicity Evaluation 1l 3 on T-5187 in Rats f T-4240 4-W eek Oral Toxicity Study ` 33 3 in Rats Dermal Sensitization Study of T- t 1i 1 5473 in Guinea Pigs - Maximization Test 4-Hour. Acute Inhalation Toxicity l 11 3 Study With T-5698 in Rats [ Acute Inhalation Toxicity Evaluation 1l 3 On T-5708 in Rats T-5486 Assessment of Cardiac r 11 3 Sensitization Potential in Dogs octafluoropropane 76-19-7 Acute inhalation Toxicity Evaluation on T-5655 in Rats [ ... T-4201 4 W eek Oral Toxicity Study ] [ ...... 3 in Rats with 2-W eek Recovery Period Lithium BisfTrifluoromethanesulfonyl)imide 90076-65-6 T-5658: Eye Irritation to the Rabbit t Acute Inhalation Toxicity Evaluation 1i 1 onT-5715in Rats t Acute Inhalation Toxicity Evaluation 3l 3 on T-5716 in Rats f Acute Inhalation Toxicity Study of T- 3f 3 5724 in Rats [ 3t 1 Acute Inhalation Toxicity Study of T- 5725 (Resin Solution) in Rats ]I_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 3_ _ _ _ J i_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 3 4 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) Acute Inhalation Toxicity Study (Limit Test) of T-5927 in Rats 1 Acute Inhalation Toxicity Study of T- 5928 in Rats (LC50) i Acute Inhalation Toxicity Evaluation on T-5829 in Rats Single-Dose Intravenous [ Pharmacokinetic Study of T-5963 in Rabbits Single-Dose Intravenous I Pharmacokinetic Study of T-6030 in Rabbits i . . . -.... -.......... I .....................................................I 1 ............................... - . I ............................................ 1 I I l. [ L_ . ] ] I ] ] 87-93% fluorinated alkyl alkoxylates; 4-10% linear N-ethyl perfiuorooctanesulfonamide; 2- 4% poly(oxy-1,2-ethanediyl),.alpha.-[2- [ethyl[(pentadecafluoroheptyl)sulfonyl]aminojeth yl]-.omega.-methoxy-; 0-4% residual organic fluorochemicals; 0-2% c8 sulfonamide; 0.1-1% 5-Daily Dose Dermal 1-heptanesulfonamide, N-ethyl- Absorption/Toxicity Study of T-6029 1,1,2,2.3,3,4,4.5,5,6.6,7.7,7-pentadecafluoro-; 87-93% 68958-61-2; 4-10% 4151-50-2; 2-4% and T-6032 in Rabbits miscellaneous components (each less than 1%) 68958-60-1; 0-2% 31506-32-8; 0.1-1% 68957-62-0 Single-Dose Intravenous Pharmacokinetic Study of T-6061 in Rabbits Single-Dose Intravenous [ 1 t. ] Pharmacokinetic Study of T-6065 in Rabbits Single Dose Intravenous [ ......................................... ... 1 . f 1 Pharmacokinetic Study of T-6063 in Rabbits [ Acute Inhalation Toxicity Study of T- ]t ..................... 1 6235 in Rats 1 Primary Dermal Irritalion/Corrosion ................................... ... 1 _. t ] Study of T-6402 in Rabbits [ 1l ] Dermal Sensitization Study of T- 6402 in Guinea Pigs- Maximization Test (EC Guidelines) t ] Acute Eye Irritation/Corrosion Study 1-Butanesulfinic acid, 1.1,2.2.3,3,4,4,4- with T-6318 in the Rabbit nonafluoro-. Sodium Salt [ ... _ 102061-82-5 I 5 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) Primary Skin Irritation / Corrosion Study with T-6567 in the Rabbit (4- Hour Semi-Occlusive Application) t Assessment of Contact 1 Hypersenitivity to T-6318 in the Albino Guinea Pig (Maximization 1-Butanesulfinic acid, 1,1,2,2,3,3,4,4,4- Test) nonafluoro-, Sodium Salt Single-Dose Intravenous Pharmacokinetic Study of T-6502 in Rabbits Single-Dose Intravenous [ ] Pharmacokinetic Study of T-6504 in Rabbits Single Dose Intravenous t ] Pharmacokinetic Study of T-6506 in Rabbits i A Study for Effect on Embryofoeta! 1 Development of the Rat (Inhalation 20-80% methyl nonafluoroisobutyl ether; 20- Administration) 80% methyl nonfluorobutylether Bacterial Reverse Mutation Test of T 6695 l ] 5-day Inhalation Toxicity of Perfluorocyclohexene ([ ]; T- 70% crude perfluorocyclohexene; 30% 6878) in Rats perfluoromethylcyclopentene 5-Daily Dose Dermal Absorption/Toxicity Study of T-6502 and T-6503 in Rabbits Primary Eye Irritation/Corrosion [ I Study of T-6786 in Rabbits Lithium Bis(perfluoroethylsulfonyl)imide Primary Dermal Irritation/Corrosion Study of T-6804 in Rabbits Lithium Bis(perfluoroethylsuifonyi)imide 5-Day Inhalation Toxicity Screen of HFE( 1 C-C6F110CH3 Primary Eye Irritation/Corrosion Study of T-6804 in a Rabbit (OECD Guidelines) Lithium Bis(perfluoroethyisulfonyl)imide Acute Oral Toxicity Study of T-6804 in Rats (OECD Guidelines) Lithium Bis(perfluoroethylsulfonyl)imide Dermal Sensitization Study of T6908 in Guinea Pigs, Mazimizatton Test (EC Guidelines) 102061-82-5 i ................. I l _J [ ]. 20-80% 163702-08-7; 20-80% 163702-07-6 [] 70% 355-75-9 [ 132843-44-8 132843-44-8 4943-08-2 1 132843-44-8 132843-44-8 6 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) Eye Irritation/Corrosion Study of T- N-Me Fos Amide-Triphenylbenzyl Phosphonium 4127 in the Rabbit Chloride Complex; D-1624 31506-32-8 Single-Dose Intravenous Pharmacokinetic Study of T-6924 in Rabbits [ J[ 1 Derma! Sensitization Study of T6924 in Guinea Pigs- Maximization Test (EC Guidelines) r ]t I Dermal Sensitization Study of T- 7003 in Guinea Pigs - Maximization Test (EC Guidelines) [ Report of Sera and Liver Data for [ N-ethyl heptadecafiuoro-N[2- J ] Monoester - Preliminary ADME (phosphonooxy)ethyl) octanesulfonamide Study in Rats diammonium salt [ ) Diester-Pharmacokinetic Study in Rats (Study No. T-7043.1, ammonium DT-26) bisfethyl(perfluorooctane)sulfonayl]phosphate Single Dose Intravenous Pharmacokinetic Study with T-7082 in Rabbits i ...................... N-ethyl heptadecafluoro-N[2- j [ ] Monoester - Pharmacokinetic (phosphonooxy)ethyl] octanesulfonamide Study in Rats (Study No. T-6997.2) diammonium salt Determination of PFOS Presence and Concentration in Serum from the Dermal Absorption Studies of T- 7106 and T-7107 in Hra:(NZW)SPF Rabbits Dermal Sensitization Study of T- t I 7285.5 in Guinea Pigs - Maximization Test (EPA/OECD Guidelines) l Twenty-eight Day Repeated-Dose J Oral Toxicity Study of T-6861 in Rats Lithium Bis(perfluoroethylsulfonyl)imide Twenty-eight Day Repeated Dose Oral Toxicity Study of T-7005 in Rats I _________________________________ 1 t 67969-69-1 30381-98-7 I ... 67969-69-1 I 1 I _ ................... ] I_ 132843-44-8 I 1_________________________________ 1_________ 7 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) Acute (4-Hour) Inhalation Toxicity of Test Atmospheres Obtained after Heating { ] in Rats I_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ J Toxicokinetic Study of Perflurooctanesulfonamidoacetate ([ ]; T-7071.2) in Rats perfluorooctanesulfonamido carboxylic acid [ .................................. 2806-24-8 J Acute Nose-Only Inhalation Toxicity Study of T-7087, T-7088, T-7089 and T-7090 in Rats (Limit Test) i _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 11_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ L Acute Ocular Irritation Study of T- 7485 Applied to New Zealand White Rabbits potassium nonafluorobutanesulfonate Toxicokinetic Study of Perfluorooctane Sulfonamide (PFOSA; T-7132.2) in Rats perfluorooctanesulfonamide Acute Four-Hour Inhalation Study in Perflurobutanesulfonyl Fluoride (96-98% ) And Rats Perfluorosulfolane (2-4% ) Primary Eye Irritation/Corrosion Study of T-7508.2 in Rabbits MV31 K-Salz; Test for Primary [ ........................ J Dermal Irritation in the Rabbit [ Assessment of Acute Oral Toxicity ........................1 . with T-7560 In The Rat (Acute Toxic Class Method) 1 Acute Eye Irritation/Corrosion Study .... J with T-7560 in the Rabbit ( ] Potassium bis- l 1 (perfluorobutanesulfonyl)imide Repeat Dose ADME Study in Rats Potassium bis(perfluorobutanesulfonyl)imide Toxicity Study by Repeat Dose Inhalation Administration to CD Rats Perflurobutanesulfonyl Fluoride (96-98% ) And for 4 Weeks Perfluorosulfolane (2-4% ) { l 29420-49-3 754-91-6 96-98% 375-72-4; 2-4% 42060-64-0 I [ [_ 1. ... 129135-87-1 96-98% 375-72-4; 2-4% 42060-64-0 ] 1 1 1 ] I A Sub-acute( 28 Day) Inhalation Toxicity Study, Including a Recovery 1,1,1,2,2,4,5.5,5-nonafiuoro-4-(trifluoromethyl)-3 Study, with.T-7479 in Rats pentanon 756-13-8 Xenochemical Receptor trans- Activation by Perfluorooctane-based Chemicals perfluorooctanesulfonamide 754-91-6 8 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) 84% 1-octanesutfonic acid, 1.1.2,2.3,3,4,4,5,5,6,6.7,7,8,8,8- heptadecafluoro-, potassium salt: 5.5% potassium (perfluorohexyl)sulfonate; 4% potassium nonafluorobutanesulfonate; 4% potassium perfluoroheptanesulfonate; 2% potassium perfluoropentanesulfanate; 0.5% 84% 2795-39-3; 5.5% 3871-99-6; 4% 29420-49-3; unknown 4% 60270-55-5; 2% 3872-25-1 95% N-ethylperfluorooctanesulfonamidoethyl alcohol: 5% 1-heptanesulfonamide N-ethyl- 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoro-N- (2-hydroxyethyl)- 95% 1691-99-2; 5% 68555-73-7 Acute Inhalation ToxicoKinetic Study of Perfluoroctanesutfonyl Fluroide (POSF) T-7098.4 perfluorooctanesulfonyl fluoride 307-35-7 Five-Day Inhalation Toxicity Study of HFE [ ] in Male CD Rats C-C6F11-CF2-0-CH3 181214-67-5 Acute Toxicity Screen of Perfluorocyclohexene (T-6878) in 70% crude perfluorocyclohexene; 30% Rats perfluoromethylcyclopentene 70% 355-75-9 [ ] (T-7056) Toxicokinetic Study in Rats ll_________________________________ I I N-Methyl Perfluorobutylsulfonamide = 95% 1- 1 Assessment of Acute Oral Toxicity Butanesulfonamide, 1,1,2,2,3,3,4,4,4- with T-7601.3 in the Rat (Acute Nonafluoro-n-Methyl; 5% N-Methyt-4-Hydrido- Toxic Class Method) Perfluorobutylsulfonamide 68298-12-4 Subchronic 90-Day Oral Toxicity Study with T-7320 By Daily Gavage in the Rat Followed by a 28-Day Recovery Period l 1[ 1 84% 1-octanesulfonicacid, Protein Binding of Perfluorobutane 1,1,2,2,3,3,4,4,5,5,6,6,7,7.8,8,8- Sulfonate, Perfluorohexane heptadecafluoro-, potassium salt; 5.5% Sulfonate, Perfluorooctane Sulfonate potassium (perfluorohexyl)sulfonate; 4% and Perfluorooctanoate to Plasma potassium nonafluorobutanesulfonate; 4% (Human, Rat, and Monkey), and potassium perfluoroheptanesulfonate; 2% Various Human-Derived Plasma potassium perfluoropentanesulfanate; 0.5% Protein Fractions unknown potassium nonafluorobutanesulfonate potassium (perfluorohexyl)sulfonate 84% 2795-39-3; 5.5% 3871-99-6; 4% 29420-49-3; 4% 60270-55-5; 2% 3872-25-1 29420-49-3 3871-99-6 9 Master Index to Studies Submitted Under TSCA 8(e) by 3M Company on September 24, 2004 (Confidential Business Information Redacted) potassium perfluorooctanoate Five Day Inhalation Toxicity Study of [ ] Monochloride. [ ], and HCFC225cb in Male CD Rats C4F9-OCH2CI C-C6F11-CF2-0-CH3 CF2CICF2CHCIF Toxlcoklnetic Screen of [ ] (T- 7483) in Rats C 7 F 1 5C {0)N (H )C H 3 84% 1-octanesulfonic add, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8- heptadecafluoro-, potassium salt; 5.5% potassium (perfluorohexylsulfonate; 4% Low Level Oral potassium nonahuorobtanesulfonate; 4% Perfluorooctanesulfonate (PFOS) potassium perfluoroheptanesulfonate; 2% DoseToxicokinetic Study in Rats: potassium perfluoropentanesulfanate; 0.5% Serum and Liver PFOS unknown 2395-00-8 205367-42-6 (n-isomer) and 221617-86-3 (Iisomer) 181214-67-5 507-55-1 89685-56-3 84% 2795-39-3; 5.5% 3871-99-6; 4% 29420-49-3; 4% 60270-55-5; 2% 3872-25-1 10