Document JNJN3KZxkJ9NjEaL41XK2B2Na

RECEIVED OPPT NCIC 2003DEC 17 AHII: 01 t i r IS^ fG < O S ) Du Pont H uman Resources W ilm ington, Delaw are 1989 cc: A J . Playtis G A Ploeger W.E. Fayerweather {letter only) CO N FID EN TIA L August 2 8,1 99 2 Y .L POW ER, M .D. W A SHING TO N W ORKS 1 POLYMERS W ASHING TO N W O RKS SURVEILLANCE DATA M ORTALITY AND CANCER IN C ID E N C E As requested, attached for Washington Works are results of cancer incidence surveillance for 1956-1989 and mortality surveillance for 1957-1991. These data are generated from Du Ponfs Company-wide epidemiologic surveillance program . To assist in your interpretation and evaluation of the findings, IVe included a description of the methodology used . Accompanying the surveillance tables is a summary of the major findings. If these findings include a statistically significant excess(es), father follow-up may be recommended. Please call me at 773-4552 after you have had a chance to review the surveillance results so we can discuss what additional follow-up, if any, is w arran ted . JUDYW ALR ATH EPIDEMIOLOGY SECTION N -1 1 5 1 0 773-4552 Better Things for S ene' Living AaP009997 EID521393 IN TE R P R E TA TIO N O F E P ID E M IO LO G IC S U R V E ILLA N C E DATA Enclosed are tables for your site showing (1) cancer incidence surveillance from 1956 through 1989 am ong active employees and (2) mortality surveillance from 1957 through 1991 am ong active employees and pensioners. For each specific cause, the num ber of observed cases/deaths (OBS) is com pared to the num ber expected (EXP) based on the experience of the entire Com pany. Com parison is m ade by the ratio of the observed to the expected numbers of cases/deaths (O BS/EXP). Accompanying each table is descriptive text which summarizes the m ajor findings. SQmseapf gurysiiien$g Data Since 1956, cancer cases that occur am ong active em ployees In the U.S. are recorded in the Du Pont Cancer Registry. Through 1988, cases have been reported to the Registry primarily by diagnoses entered on Accident and Health Insurance (A&H) claims and by death certificates that accom pany life insurance claims filed by beneficiaries of deceased em ployees. Since 1988, insurance claims data are being used to ascertain diagnoses of cancer am ong active em ployees. Beginning in 1977, registry data sources w ere supplem ented by Cancer Registry Report forms subm itted by Com pany physicians. The Cancer Registry does not include cases diagnosed among em ployees whose cancer was first diagnosed after retirem ent or after employment term ination due to reasons other than pension. Deaths that occur am ong active and pensioned em ployees in the U.S. are recorded in the Du Pont Mortality Registry that was initiated in 1957. Deaths are identified through life insurance claims filed by beneficiaries of deceased em ployees. Deaths that occur among em ployees term inated without pension are not included since there is no uniform mechanism for identification of these deaths. M ethods To determ ine expected numbers of cases/deaths for the standardized analysis, cancer incidence and mortality rates for Du Pont em ployees (and pensioners for mortality), specific for 5-year age categories, sex and payroll class (i.e. w age or salary rod), are com puted for each cause category shown in the enclosed tables. Then, the Com pany-wide incidence/m ortality rates are multiplied by the cumulative m idyear population of em ployees (and pensioners, w here applicable) from each location, specific fo r age, sex and payroll class, over the entire study period. The sum of the products over all age groups is the expected num ber o f cases or deaths. Standardized analyses are preferred because they provide age-adjusted expected numbers and are based on actual plant populations. In isolated cases where accurate population data are not available, proportionate incidence or mortality analyses are presented. In these analyses, the observed distribution of cases/deaths by cause is com pared with that expected derived from proportions which occur AJP009998 EID521394 by cause is com pared with that expected derived from proportions which occur throughout the entire Com pany. Proportions can be misleading, however, as it is possible to have an unusual distribution of cases/deaths without there being any excess rate for any specific cause. For example, if a plant has a lower death rate from heart disease than the rate in the Com pany as a whole, the proportion of deaths from other causes would be inflated (com pared to that of the entire Com pany) in order that proportions for all causes add up to 100 percen t Tests o f S tatistical S ignificance To test whether the observed to expected ratios (OBS/EXP) given in the tables differ significantly from 1.00, we determ ine the probability that the difference between the observed and expected numbers occurred by chance alone. This probability value is obtained from the Poisson probability distribution. The difference is considered statistically significant if the probability value is less than 0.10 using the two-tailed test, in the two-tailed test, statistically significant deficits as well as excesses are denoted. Statistical significance is tested only if either the observed or expected num ber of cases or deaths is 4 or m ore. Interpretation o f S tatistically S ig n ifican t Results The designation of a statistically significant excess often suggests the need for further investigation to determ ine whether the excess may have occurred because of som e agent at the plant. However, an excess may also occur because of environmental and other factors associated with increased risks, such as smoking, diet, alcohol, ethnic origin, socioeconomic status or genetic factors. Chance alone may account for a statistically significant difference. When the level of statistical significance is set at 0.10, one should expect to find a statistically significant difference in about 10 out of every 100 comparisons due to chance alone, even when no specific causative factor is responsible. The m agnitude of the difference, expressed as the ratio of observed to expected numbers (OBS/EXP), must also be considered in data interpretation. The OBS/EXP ratio and its corresponding probability value should be considered together in assessment of the difference between an observed and expected number. It may be that the observed num ber for a particular cause is greater than the expected number, but the difference is not statistically significant. In this instance it does not necessarily follow that a particular agent at the plant may not b e associated with the moderate excess. If the num ber of persons at the plant exposed to the agent is small, excess morbidity or mortality in that group would be difficult to detect because of dilution by data from the rest of the p lan t Also, it may be too soon for effects of an agent to be m anifested by excess morbidity or mortality. 6/92 AJP009999 EID521395 Cancer Inddence WASHIN6T.Q.NWQBKS No statistically significant excess was observed in the overall cancer experience of employees at Washington Works from 1956-1989. There was, however, a statistically significant excess of cancers of the buccal cavity and pharynx am ong male wage (8 cases and 2.8 expected) and all male employees. This elevation was reported in the 1956-1987 surveillance and no additional cases have occurred since that time. A statistically significant excess of kidney and other urinary cancers was observed among all male employees (9 cases versus 4.5 expected). This excess was also present in the 1956-1987 report, among male salary as well as all male employees. One case has been diagnosed during 1988-1989. A bladder cancer excess reported during 1956-1987 am ong m ale wage employees is no longer statistically significant. No new cases have been reported during 19881989. The earlier finding of an elevation in multiple myeloma among a l men is no longer statistically significant. No new cases have been reported during 1988-1989. A new finding is a statistically significant elevation in leukemia among male w age (7 cases versus 3.01 expected) and all male employees (9 cases versus 4.56 expected). This increase results from an additional 3 cases having been diagnosed among male wage employees since the last report. A recent case-control study of leukemia at Washington Works found no association between work in any area at the plant and developm ent of leukemia. No statistically significant deficits were observed in the overall or site-specific cancer experience of employees at Washington Works during 1956-1989. Cancer experience am ong femaJe employees was not unusual. AJPOIOOOO EID521396 CAUSE OF CANCER BUCCAL CAVITY A PHARYNX ESOPHAGUS STOMACH SHALL AND LARGE INTESTINE RECTUM LIVER AND BILIARY PASSACES PANCREAS PERITONEUM UNSPEC. DIGESTIVE ORGANS NOSE, NASAL CAVITIES, ETC. LARYNX LUNG, BRONCHUS, k TRACHEA MEDIASTINUM k UNSPEC. PLEURA BREAST PROSTATE TESTIS OTHER MALE GENITAL ORGANS KIDNEY ft OTHER URINARY BLADOER MALIGNANT MELANOMA EYE BRAIN k OTHER NERVOUS SYSTEM THYROID OTHER ENDOCR1NE GLANOS BONE CONNECTIVE TISSUE LYMPHOSARCOMA k RETICULOSARCOMA HOOGKIN'S DISEASE OTHER LYMPHOMA MULTIPLE MYELOMA LEUKEMIA MYCOSIS FUNGOIDES OTHER HEMATOPOIETIC SYSTEM OTHER k UNKNOWN OBSERVED AND EXPECTED CANCER TflciDENCE USING POPULATION BASED RATES WASHINGTON (PARKERSBURG) - PLANT (LOCATION CODE = 013} 1956 - 1989, HALES SALARY ROLL WAGE ROLL WAGE + SALARY OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP 1 0 0 9 2 0 1 0 0 1 1 8 0 0 0 1 2 0 5 0 7 0 1 0 1 0 0 1 2 2 2 2 "0 1 2 1.59 0.119 0.79 5.56 1.95 0.97 1.23 0.15 0.03 0.13 0.70 7.62 0.12 0.13 0.12 2.93 1.20 0.02 2.08 2.12 3.68 0.12 1.59 0.52 0.22 0.16 0.76 1.23 0.97 0.90 0.1(9 1.56 0.12 0.18 1.65 0.63 0.00 0.00 1.62 1.03 0.00 0.82 0.00 0.00 7.51 1.88 1.05 0.00 0.00 0.00 0.38 1.66 0.00 2.80 0.00 1.90 0.00 0.63 0.00 8.60 0.00 0.00 0.81 2.07 2.23 8.05 1.28 0.00 5.88 1.21 8 2.77 2.89 * 0 1.21 0.00 0 1.69 0.00 6 7.35 0.82 3 3.82 0.88 2 1.10 1.82 2 2.26 0.89 1 0.10 9.59 0 0.01 0.00 0 0.58 0.00 3 2.07 1.85 12 15.83 0.78 0 0.18 0.00 1 0.33 3.06 0 0.10 0.00 3 9.23 0.71 2 1.78 1.15 0 0.23 0.00 8 2.85 1.63 8 8.87 1.79 5 6.86 0.73 0 0.23 0.00 3 3.30 0.91 1 1.89 0.67 1 0.23 8.35 1 0.32 3.12 1 1.25 0.80 0 1.36 0.00 2 2.80 0.83 5 2.10 2.39 2 0.98 2.12 7 3.01 2.33 0 0.00 0 0.22 0.00 1 2.30 0.83 9 9.36 2.06 * 0 1.71 0.00 0 2.98 0.00 15 12.91 1.16 5 5.38 0.93 2 1.57 1.20 3 3.98 0.86 1 0.25 8.00 0 0.03 0.00 1 0.68 1.98 8 2.77 1.89 20 23.05 0.87 0 0.3 0.00 1 0.95 2.21 0 0.22 0.00 8 7.16 0.56 8 2.98 1.36 0 0.25 0.00 9 8.53 1.98 * 8 6.58 1.22 12 10.59 1.18 0 0.35 0.00 9 9.89 0.82 1 2.01 0.50 2 0.95 8.87 1 0.98 2.08 1 2.00 0.50 1 2.59 0.39 8 3.36 1.19 7 2.99 2.38 * 8 1.99 2.78 9 856 1.97 0 0.12 0.00 1 0.81 2.96 3 3.95 0.76 TOTAL ALL CAUSES 52 83.56 1.19 88 77.69 1.08 STAT SIGNIFICANT EXCESS (*) / DEFICIT (#) AT 2-TAILED 0.10 LEVEL (CALCULATED ONLY WHERE EITHER OBS OR EXP GE A) 136 121.26 1.12 NOTE: OTHER SKIN CANCER NOT INCLUDED IN THIS REPORT AJPOlOOOl CAUSE or CANCER BUCCAL CAVITY k PHARYNX ESOPHAGUS STOMACH SHALL AND LARGE INTESTINE RECTUM LIVER AND BILIARY PASSAGES PANCREAS PERITONEUM NOSE, NASAL CAVITIES, ETC. LARYNX LUNG, BRONCHUS, k TRACHEA BREAST CERVIX OTHER FEMALE GENITAL ORGANS KIONEY k OTHER URINARY BLADDER MALIGNANT MELANOMA EYE BRAIN k OTHER NERVOUS SYSTEM THYROID OTHER ENDOCRINE GLANDS BONE CONNECTIVE TISSUE LYMPHOSARCOMA k RET1CULOSARCONA HODGKIN'S DISEASE OTHER LYMPHOMA MULTIPLE MYELOMA LEUKEMIA MYCOSIS FUNGOIDES OTHER k UNKNOWN OBSERVED AND EXPECTEO CANCER TNtlOENCE USING POPULATION BASED RATES WASHINGTON (PARKERSBURG) - PLANT (LOCATION CODE = 013) 1956 - 1989, FEMALES SALARY ROLL WAGE ROLL WAGE + SALARY OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP 0 0.0*1 0.00 0 0.00 0.00 0 0.10 0.00 0 0.35 0.00 0 0.15 0.00 0 0.00 - 0 0.05 0.00 0 0.00 - 0 0.01 0.00 0 0.02 0.00 0 0.47 0.00 2 2.78 0.72 0 1.62 0.00 0 1.03 0.00 0 0.02 0.00 0 0.08 0.00 2 0.43 4.70 0 0.01 0.00 0 0.11 0.00 1 0.32 3.16 0 0.00 - 0 0.08 0.00 0 0.09 0.00 0 0.14 0.00 0 0.17 0.00 0 0.14 0.00 2 0.09 21.28 0 0.10 0.00 0 0.00 0 0.16 0.00 0 0.07 0.00 0 0.00 - 0 0.00 - 0 0.13 0.00 0 0.11 0.00 0 0.05 0.00 0 0.02 0.00 0 0.00 0.00 0 0.00 - 0 0.01 0.00 0 0.07 0.00 3 1.71 1.75 4 1.39 2.88 0 0.30 0.00 0 0.11 0.00 0 0.02 0.00 1 0.22 4.48 0 0.00 0 0.00 0.00 0 0.02 0.00 0 0 0.09 0.00 0.00 1 0.07 13.39 0 0.06 0.00 0 0.03 0.00 0 0 0.14 0.00 0.00 0 0.10 0.00 0 0.00 0 0.13 0.00 0 0.12 0.00 0 0.00 0.00 0 0.10 0.00 0 0.48 0.00 0 0.27 0.00 0 0.05 0.00 0 0.07 0.00 0 0.00 0.00 0 0.01 0.00 0 0.04 0.00 0 0.55 0.00 5 4.49 1.11 4 3.01 1.33 0 1.33 0.00 0 0.13 0.00 0 0.10 0.00 3 0.65 4.63 0 0.01 0.00 0 0.11 0.00 1 0.34 2.96 0 0.09 0.00 0 0.08 0.00 1 0.16 6.12 0 0.20 0.00 0 0.20 0.00 0 0.28 0.00 2 0.09 21.28 0 0.20 0.00 0 0.00 0 0.29 0.00 TOTAL ALL CAUSES -7 8.57 0.82 9 4.87 1.85 STAT SIGNIFICANT EXCESS () / DEFICIT (#) AT 2-TAILED 0.10 LEVEL (CALCULATED ONLY WHERE EITHER OBS OR EXP OE 4) 1 16/ 13.44 1.19 NOTE: OTHER SKIN CANCER NOT INCLUDED IN THIS REPORT 6 m u o OtNn) H O O o N WASHINGTON WORKS Mortality Statistically significant deficits are again observed in the overall mortality experience of male wage and all male employees at Washington W orks, for 1957-1991. Statistically significant deficits are seen for all m alignant neoplasms am ong male w age (60 deaths versus 78.4 expected) and all m ale employees (99 deaths versus 124.8 expected). In addition, m ale wage employees show a statistically significant deficit of respiratory cancer deaths (19 deaths versus 28.6 expected) and all male employees have a significant deficit of digestive cancer deaths (22 deaths versus 32.0 expected). t There is a statistically significant deficit of deaths from cerebrovascular disease am ong male w age employees (6 deaths versus 13.9 expected) and all male employees (12 deaths versus 20.8 expected). The deficit in male w age employees was reported in the 1957-1987 rep o rt A significant deficit is seen among all male employees for suicide (3 observed versus 10.8 expected). Among female em ployees, there is a statistically significant excess of 'residual1 causes of death (4 deaths versus 1.05 expected). AJP010003 EID521399 OBSERVED AND EXPECTED DEATHS USING POPULATION-BASED RATES WASHINGTON (PARKERSBURG) - PLANT (LOCATION CODE = 013) 1957 - 1991, HALES SALARY ROLL WAGE ROLL WAGE + SALARY CAUSE OF DEATH OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP MALIGNANT NEOPLASMS BUCCAL CAVITY ft PHARYNX DIGESTIVE ORGANS RESPIRATORY SYSTEM BREAST GENITAL ORGANS URINARY ORGANS LYMPHATIC, ETC. OTHER ft UNSPECIFIED TOTAL MALIGNANT NEOPLASMS 1 0.89 1.13 9 12.48 0.72 15 14.76 1.02 0 0.10 0.00 4 3.56 1.12 0 2.65 0.00 5 5.28 0.95 5 6.71 0.75 39 46.43 0.84 2 1.52 1.32 13 19.53 0.67 19 28.60 0.66 i 0 0.09 0.00 3 5.54 0.54 4 3.68 1.09 9 8.66 1.04 10 10.75 0.93 60 78.37 0.77 # 3 2.41 1.25 22 32.01 0.69 i 34 43.36 0.78 0 0.19 0.00 7 9.11 0.77 4 6.33 0.63 14 13.93 1.00 15 17.46 0.86 99 124.80 0.79 CEREBROVASCULAR DISEASE 6 6.98 0.86 6 13.86 0.43 12 20.84 0.58 # DISEASES OF THE HEART CHRONIC RHEUMATIC HEART DISEASE ARTERIOSCLEROTIC HEART DISEASE CHRONIC ENDOCARDITIS HYPERTENSIVE HEART OISEASE OTHER HEART DISEASE 2 0.70 2.85 55 49.70 1.11 1 0.30 3.30 0 1.10 0.00 14 8.99 1.56 2 0.78 2.57 83 89.73 0.92 0 0.54 0.00 1 1.93 0.52 18 16.35 1.10 4 1.48 2.70 138 139.43 0.99 1 0.85 1.18 1 3.03 0.33 32 25.34 1.26 OTHER CARDIOVASCULAR DISEASE RHEUMATIC FEVER HYPERTENSION WITHOUT MENTION OF HEART GENERALIZED ARTERIOSCLEROSIS OTHER 0 2 2 6 0.02 0.44 0.46 3.35 0.00 4.53 4.31 1.79 0 0.02 0.00 0 0.64 0.00 0 0.67 0.00 4 5.17 0.77 0 0.04 0.00 2 1.09 1.84 2 1.13 1.77 10 8.52 1.17 EXTERNAL CAUSES OF DEATH MOTOR VEHICLE ACCIDENTS SUICIDE HOMICIDE OTHER ACCIDENTS OTHER CAUSES INFLUENZA PNEUMONIA NEPHRITIS ft NEPHROSIS TUBERCULOS1S OF RESPIRATORY SYSTEM DIABETES MELLITUS PEPTIC ULCER APPENDICITIS HERNIA ft INTESTINAL OBSTRUCTION CIRRHOSIS OF THE LIVER EMPHYSEMA SYMPTOMS ft ILL-DEFINED CONDITIONS RESIDUAL UNSPECIFIED 6 0 0 3 - 0 5 0 0 2 0 0 0 2 1 1 12 0 3.53 3.03 0.34 3.26 0.03 2.36 0.73 0.03 1.03 0.42 0.06 0.23 1.81 1.08 1.27 13.16 0.62 1.70 0.00 0.00 0.92 0.00 2.12 0.00 0.00 1.95 0.00 0.00 0.00 1.11 0.92 0.79 0.91 0.00 9 15.17 0.59 3 7.75 0.39 1 2.65 0.38 4 8.81 0.45 0 0.09 0.00 4 4.23 0.95 1 1.81 0.55 0 0.22 0.00 2 2.62 0.76 0 0.76 0.00 0 0.01 0.00 1 0.31 3.21 1 3.48 0.29 3 2.47 1.21 1 2.84 0.35 19 23.32 0.81 2 1.47 1.36 15 18.70 0.80 3 10.78 0.28 # 1 2.99 0.33 7 12.07 0.58 0.12 0.00 9 6.59 1.37 1 2.54 0.39 0 0.26 0.00 4 3.64 1.10 0 1.18 0.00 0 0.07 0.00 1 0.55 1.83 3 5.29 0.57 4 3.55 1.13 2 4.11 0.49 31 36.48 0.85 2 2.09 0.95 AJP010004 TOTAL ALL CAUSES 159 151.48 1.05 225 286.08 0.79 # 384 437.56 0.88 # STAT SIC EXCESS (*) / DEFICIT (#) AT 2-TAILED 0.10 LEVEL (CALCULATED ONLY WHERE EITHER OBS OR EXP GE 4) OBSERVED AND EXPECTED DEATHS USING POPULATION-BASED RATES WASHINGTON (PARKERSBURG) - PLANT (LOCATION CODE = 013) 1957 - 1991, FEMALES SALARY ROLL WAGE ROLL WAGE + SALARY CAUSE OF DEATH OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP OBSERVED EXPECTED OBS/EXP MALIGNANT NEOPLASMS BUCCAL CAVITY fe PHARYNX DIGESTIVE ORGANS RESPIRATORY SYSTEM BREAST GENITAL ORGANS URINARY ORGANS LYMPHATIC, ETC. OTHER fe UNSPECIFIED TOTAL MALIGNANT NEOPLASMS 0 0.02 0.00 0 0.88 0.00 0 0.18 0.00 0 0.98 0.00 0 0.11 0.00 0 0.05 0.00 0 0.35 0.00 1 0.112 2.39 1 3.15 0.32 0 0.00 0.00 0 0.28 0.00 0 0.18 0.00 1 0.65 1.53 0 0.13 0.00 0 0.08 0.00 0 0.26 0.00 0 0.13 0.00 1 1.67 0.60 0 0.02 0.00 0 0.69 0.00 0 0.66 0.00 1 1.63 0.61 0 0.58 0.00 0 0.12 0.00 0 0.61 0.00 1 0.55 1.83 2 8.81 0.82 CEREBROVASCULAR DISEASE 0 0.35 0.00 0 0.28 0.00 0 0.60 0.00 DISEASES OF THE WART CHRONIC RHEUMATIC HEART DISEASE ARTERIOSCLEROTIC HEART DISEASE CHRONIC ENDOCARDITIS HYPERTENSIVE HEART DISEASE OTHER WART DISEASE 0 0.09 0.00 2 0.71 2.BO 0 0.01 0.00 0 O.Oll 0.00 2 0.23 8.57 0 0.00 0 0.22 0.00 0 0.00 0 0.00 0 0.07 0.00 0 0.09 0.00 2 0.98 2.18 0 0.01 0.00 0 0.08 0.00 2 0.31 6.89 OTHER CARDIOVASCULAR DISEASE RHEUMATIC FEVER HYPERTENSION WITHOUT MENTION OF HEART GENERALIZED ARTERIOSCLEROSIS OTHER 0 0 0 0 0.00 0.01 0.01 0.10 - 0.00 0.00 0.00 0 0.00 0 0.00 0 0.01 0.00 0 0.03 0.00 0 0.00 0 0.01 0.00 0 0.02 0.00 0 0.13 0.00 EXTERNAL CAUSES OF DEATH MOTOR VEHICLE ACCIDENTS SUICIDE HOMICIDE OTWR ACCIDENTS 1 0.5* 1.86 0 0.12 0.00 0 0.11 0.00 0 0.11 0.00 0 0.38 0.00 0 0.16 0.00 0 0.27 0.00 0 0.08 0.00 1 0.88 1.18 0 0.28 0.00 0 0.37 0.00 0 0.15 0.00 OTHER CAUSES INFLUENZA PNEUMONIA NEPHRITIS ft NEPHROSIS TUBERCULOSIS OF RESPIRATORY SYSTEM DIABETES NELLITUS PEPTIC ULCER APPENDICITIS HERNIA fe INTESTINAL OBSTRUCTION CIRRHOSIS OF THE LIVER EMPHYSEMA SYMPTOMS fe ILL-DEFINED CONDITIONS RESIDUAL UNSPECIFIED 0 0.01 0.00 0 0.09 0.00 0 0.00 - 0 0.00 - 0 0.08 0.00 0 0.01 0.00 0 0.00 - 0 0.00 . 0 0.06 0.00 0 0.08 0.00 1 0.11 9.39 2 0.73 2.73 0 0.02 0.00 0 0.00 0 0.08 0.00 0 0.03 0.00 0 0.00 0 0.01 0.00 0 0.00 0.00 0 0.00 0 0.00 - 0 0.01 0.00 0 0.00 0.00 0 0.03 0.00 2 0.32 6.31 0 0.09 0.00 0 0.01 0.00 0 0.12 0.00 0 0.03 0.00 0 0.00 0 0.08 0.00 0 0.01 0.00 0 0.00 0 0.00 0 0.07 0.00 0 0.08 0.00 1 0.18 7.08 8 1.05 3.81 * 0 0.11 0.00 TOTAL ALL CAUSES 9 6.68 1.35 3 3.58 0.88 12 10.26 1.17 STAT SIG EXCESS (*) / DEFICIT (#) AT 2-TAILED 0.10 LEVEL (CALCULATED ONLY WHERE EITHER OBS OR EXP GE 8) EID521401 O O o in