Document GwDKqo51kV5VdyOn25xQ3X7V

61. Harbison, R.O. Teratology, Chapter 5 in Casarett and Doull's Toxico logy, Macmillan Publishing Company, New York, 1980. 62. Wells, P.6., R.C. Boerth, J.A. Oates and R.O. Harbison. Toxicologic enhancement by a combination of drugs which deplete hepatic glutathi one: Acetaminophen and doxorubicin (Adriamycin). Toxicol. Appl. Pharmcol. 54:197-209, 1980. 63. Koshakji, R.P., M.T. Bush and R.O. Harbison. Metabolism and distribu tion of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) in pregnant mice. J. Environ. Sci. Health 4:315-334, 1980. 64. Olson, R.D., J.S. MacDonald, R.D. Harbison, C.J. Van Boxtel, R.C. Boerth and J.A. Oates. Altered myocardial glutathione levels: A possible mechanism of adriamycin toxicity. J. Pharmacol. Exp. Therap. 215:450-454, 1980. 65. Harbison, R.D., W.W. Eckenfelder, G. Gallagher and G. Moein. National Hazardous Materials Training Program. Proceedings of 1980 National Conference on Control of Hazardous Material Spills, 492-494, 1980. 66. Clarke, J.H., F.G. Ziegler, R.D. Harbison and R.C. James. A Model for Assessment of Environmental Impact of Hazardous Materials Spills and Leaching. Proceedings of 1980 National Conference on Control of Hazardous Material Spills, pp. 293-295, 1980. 67. Wells, P.G. and R.D. Harbison. Significance of the phenytoin reactive arene oxide intermediate, its oxepin tautomer, and clinical factors modifying their role in phenytoin-induced teratology. In: Phenytoininduced Teratology and Gingival Pathology, T.M. Hassell, M.C. Johnson and R.H. Dudley, eds.. Raven Press, New York, pp. 83-108, 1980. 68. Wood, Margaret, M.L. Berman, R.D. Harbison, Peter Hoyle, J.M. Phythyon and A.J.J. Wood. Halothane-induced hepatic necrosis in triiodothyronine pretreated rats. Anesthesiology 52:470-476, 1980. 69. Harbison, R.D. Acetaminophen as an aspirin substitute: Is it safer? Chemical Dependencies: Behavioral and Biomedical Issues. 4(2):71-84, Spectrum Publications, Inc. 1980. 70. Fant, M.E., K.V. Speeg, S. Harper and R.D. Harbison. Cholinergic elements in a human choriocarcinoma cell line. Biochem. Pharmcol. 30:967-970, 1981. 71. Freeman, R.W. and R.D. Harbison. Hepatic periportal necrosis induced by chronic administration of cocaine. Biochem. Pharmacol. 30:777-783, 1981. 72. Smith, A.C., R.W. Freeman and R.D. Harbison. Ethanol enhancement of cocaine-induced hepatotoxicity. Biochem. Pharmacol. 30:453-458, 1981. 15 URL 07216 73. Freeman, R.W. and R.D. Harbison. The rote of benzoylmethylecgonine in cocaine-induced hepatotoxicity. J. Pharmacol. Exp. Ther. 218(2):558557, 1931. 74. Freeman, R.W., J.P. Uetrecht, R.L. Woosley, J.A. Oates and R.D. Harbison. Covalent binding of procainamide _in vivo and jn vitro to hepatic protein in mice. Drug Metab. Dispos. 9:188-192, 1981. 75. Goodman, D.R. and R.D. Harbison. Characterization of enzymatic acetylcholine synthesis by mouse brain, rat sperm, and purified carni tine acetyltransferase. Biochem. Pharmacol. 30(12):1521-1528, 1981. 76. Fant, M.E. and R.D. Harbison. Syncytiotrophoblast membrane vesicles: A model for examining the human placental cholinergic system. Teratology 24(2):187-199, 1981. 77. Goodman, D.R., R.C. Dames and R.D. Harbison. Placental Toxicology. Food Chem. Toxicol. 20:123-128, 1982. 78. James, R.C. and R.D. Harbison. Hepatic glutathione and hepatotoxi city: The effect of cytochrome P-450 complexing compounds SKF525-A, L-alpha-acetylmethadol (LAAM), norLAAM and piperonyl butoxide. Biochem. Pharmacol. 31(10):1829-1835. 1982. 79. James, R.C., D.R. Goodman and R.D. Harbison. Hepatic glutathione and hepatotoxicity: Changes induced by selected naracotics. 0. Pharmacol. Exp. Ther. 221(3):708-714, 1982. 80. Wells, P.G., A. Kupfer, J.A. Lawson and R.D. Harbison. Relation of in vivo drug metabolism to steroselective fetal hydantoin toxicology in mice: Evaluation of mephenytoin and its metabolite, nirvanol. J. Pharmacol. Exp. Ther. 221(1):228-234, 1982. 81. Jernigan, J.D. and R.0. Harbison. Role of biotransformation in the potentiation of halocarbon hepatotoxicity by 2,5-hexanedione. J. Toxicol. Environ. Health, 9:761-781, 1982. 82. Goodman, D.R., R.C. James and R.D. Harbison. Chemical-induced heritable cell changes: Description of mutagenicity assays and appli cation of test results in Gonads edited by R.L. Dixon and R.D. Harbison, Raven Press, New York, 1983. 83. Goodman, D.R., M.E. Fant and R.D. Harbison. Perturbation of aminoisnbutyric acid (AIB) transport in human placental membranes: Direct effects by HqCln, CH-sHgCl and CdCl?. Terato. Carcino. Mutagen. 3(1) :89-100, 1983. 84. Jernigan, J.D. , J.G. Pounds and R.D. Harbison. Pc tentiation of chlorinated ' drocarbon toxicity by 2,5-hexanedione in primary cultures of It rat hepatocytes. Fund. Appl. Toxicol. 3(1):22-26, 1983. 16 85. Ali, S.F., J.M. Cranmer, P.T. Goad, W. Slikker, R.D. Harbison and M.F. Cranmer. Trimethyltin-induced changes of neurotransmitter levels and brain receptor binding in the mouse. Neurotoxicology 4:29-36, 1983 86. James, R.C., S. Roberts and R.D. Harbison. The perturbation of hepatic glutathione by alpha^-adrenergic agonists. Fund. Appl. Toxicol. 3:303-308, 1983. 87. Freeman, R.W. and R.D. Harbison. Analysis of alpha-fetoprotein: A comparison of three radioimmunoassays. Terato. Mutagen. Carcino. 3:407-420, 1983. 88. Smith, A.C., L.M. Berman, R.C. James and R.D. Harbison. Characteriza tion of hyperthyroidism enhancement of halothane-induced hepatotoxicity. Biochem. Pharmacol. 32(23):3531-3539, 1983. 89. Smith, A.C., R.C. James, L.M. Berman, and R.D. Harbison. Paradoxical effects of perturbation of intracellular levels of glutathione on halothane-induced hepatotoxicity in hyperthyroid rats. Fund. Appl. Toxicol. 4(2):221-230, 1984. 90. James, R.C., R.W. Freeman and R.D. Harbison. L-Alpha-acetylmethadolInduced tissue alterations in mice. Drug Chem. Toxicol. 7(1):91-112. 1984. 91. Koshakji, R.P., R.D. Harbison and M.T. Bush. Studies on the Metabolic Fate of {^C)2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse. Toxicol. Appl. Pharmacol. 73(1):69-77 1984. 92. Goodman, D.R., F.K. Adatsi and R.D. Harbison. Evidence for the extreme overestimation of choline acetyltransferase in human sperm, human seminal plasma and rat heart: A case of mistaking carnitine acetyltransferase for choline acetyltransferase. Chemico-Biological Interactions. 49:39-53, 1984. 93. Teaf, C.M., R.D. Harbison and R.W. Freeman. Cocaine-induced hepatotoxicity: Lipid peroxidation as a possible mechanism. Drug Chem. Toxicol. 7(4):383-396, 19S4. 94. Goodman, D.R., R.C. James and R.D. Harbison. Assessment of mutagenicity using germ cells and the application of test results. Tn: Reproductive Toxicology. R.L. Dixon, ed.. Raven Press, 1985. 95. Teaf, C.M., J.B. Bishop and R.D. Harbison. Germ cell mutagenesis and glutathione depression in reproductive tissues of the F344 rat induced by ethyl methane sulfonate. Mutat. Res. 144:93-98, 1985. 96. Jarmer, S, A.R. Shoaf and R.D. Harbison. Comparative enzymatic acetylation of carnitine and choline by human placenta syncytiotrophoblast membrane vesicles. Terato. Mutagen. Carcino., 5:445-461, 1985. 17 URL 07217 I URL 07218 97. Shoaf, A.R., S. Jarmer and R.D. Harbison. Heavy Metal Inhibition of Carnitine Acetyltransferase Activity in Human Placental Syncytiotrophoblast: Possible Site of Action of HgClj, CH3HgCl and CdC1^* Terato. Mutagen. Carcino., In press, 1986. 98. Jernigan, J.D., J.G. Pounds and R.D. Harbison. Structure-activity studies of ketone-induced potentiation of halocarbon hepatotoxicity in mice. Toxicology, In press, 1986. 99. Roberts, S.M., V.R. Grund, R.C. James and R.D. Harbison. Histamine and hepatic glutathione in the mouse. Life Sciences, In press, 1986. 100. Gandy, J., C.M. Teaf, F.A. Adatsi, R.C. James and R.D. Harbison. The dependence of male reproductive toxicity on qerm cell stage. Proceedings of Functional Teratogenesis - The Functional Effects on the Offspring After Parental Drug Exposure, Satellite Symposium of the Fourth International Congress of Toxicology, Tokyo, Japan, In press, 1986. 101. Teaf, C.M., J.B. Bishop and R. D. Harbison. Depression of glutathione in male reproductive tissues and potentiation of EMS-induced germ cell mutagenesis by L-buthionine sulfoximine. Submitted, 1986. 102. James, R.C., M.A. Schiefer, S.M. Roberts and R.D. Harbison. Adrenergic antagonism of cocaine-induced hepatotoxicity. Toxicol. Appl. Pharmacol., Submitted, 1986. 103. Smith, A.C., R.C. James, l.M. Berman and R.D. Harbison. Halothane metabolism in hyperthyroid rats and its possible role in the halothane-induced hepatotoxicity. Drug Metab. Disp., Submitted, 1986. 104. Harbison, R.D., C.C. Conaway, L.F. Rubin and J. Gandy. A study of chronic morpholine exposure of rats. Toxicol. Appl. Pharmacol., Submitted, 1986. 18 URL 07219 ABSTRACTS Papers Presented at Scientific Meetings Harbison, R.D. Effect of phenobarbital pretreatment of novobiocininduced hyperbilirubinemia. Federation Proceedings. 26, March -April, 1967. 2. Harbison, R.O. and B.A. Becker. Comparison of mortality rates of some barbiturates in normal and triiodothyronine-induced hyperthyroid rats. Society of Toxicology, Seventh Annual Meeting, March 1968, Toxicology and Applied Pharmacology. 12, 316, 1968. 3. Harbison, R.D., C.D. Klaassen and B.A. Becker. The effect of altered thyroid state on the hemodynamics of the isolated perfused rat liver. Gastroenterology. American Association for the Study of Liver Disease, Chicago, 1968. 4. Fling, T.E., R.D. Harbison, B.A. Becker and J.R. Fouts. Effect of diphenylhydantoin treatment on spectral and kinetic properties of hepatic microsomal enzymes in newborn and adult rats. The Pharmacolo gist. 11, 248, 1969. 5. Harbison, R.O. and B.A. Becker. Phenobarbital and SKF 525-A effect on placental transfer, distribution and excretion of diphenylhydantoin in pregnant mice. The Pharmacologist. 11, 248, 1969, 6. Harbison, R.D., T.E. Eling and B.A. Becker. Effects of diphenylhydan toin on neonatal rat liver drug metabolizing enzymes. Federation Proceedings. 28, 676, 1969. 7. Harbison, R.D. and B.A. Becker. Phenobarbital and SKF 525-A altera tion of diphenylhydantoin teratogenicity in mice. Society of Toxicology Eighth Annual Meeting, March 1969. Toxicology and Applied Pharmacology. 14, 55, 1969. 8. Harbison, R.D. and B.A. Becker. Studies on the mechanism of diphenylhydantoin teratogenicity. Society of Toxicology, Ninth Annual Meeting, March 1970. Toxicology and Applied Pharmacology. 15, 1970. 9. Darby, l.J. and R.D. Harbison. Comparative distribution of parathion in normal and phenobarbital pretreated pregnant mice. The Pharmacolo gist. 12, 280, 1970. 10. Harbison, R.D, Maternal distribution and placental transfer of 14Ctetrahydrocannabinol in pregnant mice. Society of Toxicology, Tenth Annual Meeting, March 1971. 11. George, W.J., G.M. Rodgers, III, J.l. Gibson and R.D. Ha'ison. Morphine and ethylmorphine metabolism in neonatal and adult rats. Federation of American Society of Experimental Biology, 1971. 19 URL 07220 12. Manti11a-Plata, B. and R.D. Harbison. Phenobarbetal and SKF 525-A effect on delta^-tetrahydrocannabinol (THC) toxicity and distribution in mice. The Pharmacologist. 13, 1971. 13. _$tevens, M.W. and R.D. Harbison.- Influence of species', time of gesta tion, and route of injection on placental transfer of diphenylhydantoin (DPH). Fifth International Congress on Pharmacology, San Francisco, California, 1972. 14. Harbison, R.D. DDT, heptachlor, chlordane and parathion toxicity in adult, newborn and phenobarbital treated newborn rats. Society of Toxicology, Twelfth Annual Meeting, March 1973. 15. Mantilla-Plata, B., G.L. Clewe and R.D. Harbison. Teratogenic and mutagenic studies of delta^-tetrahydrocannibol in mice. Federation of American Society of Experimental Biology, 1973. 16. Olubadewo, 0., M.W. Stevens, B.V. Rama Sastry and R.D. Harbison. Studies of the role of endogenous acetylcholine in placental trans port. Pharmacologist. Vol. 15, 1973. 17. Koshakji, R.P., M. Hoscher, M. Boyd and R.D. Harbison. Studies of the toxins Rubratoxin B, Ipomeanine and Ip. oanol during perinatal development and in the adult. Pharmacologist. Vol. 15, 1973. 18. Rama Sastry, B.V., J. Olubadewo, M.W. Stevens and R.D. Harbison. Localization and gestational variation of placental choline acetyltransferase and acetylcholine and their significance. British Pharmacology Society, London, December, 1973. 19. Harbison, R.D. Women in industry-teratological implications. Sympo sium American Academy of Occupational Medicine, 1973. 20. Harbison, R.D. and B.V. Rama Sastry. A function cholinergic sytem in human placenta. Symposium on Perinatal Pharmacology, Milan, Italy, June 1974. 21. Harbison, et _al_. Male antifertility activity of trimethyl phosphate: Possible ole of a spermic cholinergic system. International Sympo sium on Reproduction, New Delhi, India, 1974. 22. Mantilla-Plata, 8. and R.D. Harbison. Distribution studies of *4Cdelta-9-tetrahydrocannabinol (THC) in mice. Society of Toxicology, Thirteenth Annual Meeting, March, 1974. 23. Harbison, R.D., C. Dwivedi and B.V. Rama Sastry. Development of sperm choline acetyltransferase activity: Studies on mechanisms of antifer tility activity of trimethyl phosphate. American Society of Pharmaco logy and Experimental Therapeutics, August 1974. 20 24. Dwivedi, C., A. Basheer, S.S. Parmar and R.D. Harbison. Selective inhibition of nicotinamide adenine dinucleotide dependent oxidations by substituted carbamides. American Society of Pharmacology and Experimental Therapeutics, August, 1974. 25. Harbison, R.D. and B.V. Rama Sastry. Studies of a functional cholinergic system in human placenta. Federation of American Society of Experimental Biology, 1974. 26. Dwivedi, C., S.S. Parmar and R.D. Harbison. Antihemolytic and anti convulsant activity of some substituted thiosemicarbazides and their inhibition of NAD-dependent oxidations and monoamine oxidase. Society of Toxicology, March 9-13, Williamsburg, VA, 1975. 27. Jones, M.M. and R.D. Harbison. Synthesis and study of some new chelating agents to antagonize methylmercury-induced toxicity. Society of Toxicology. March 9-13, 1975. 28. Stevens, M.W. and R.D. Harbison. Placental transfer and uptake of diphenylhydantoin and alpha-aminoisobutyric acid by animal and human placenta. Teratology Society, 1974 meeting, Vancouver, B.C. 29. Harbison, R.D., C. Dwivedi and M.A. Evans. Functional significance of inhibiting spermatozoa choline acetyl transferase. American Society of Pharmacology and Experimental Therapeutics. University of California, Davis, California, August 1975. 30. Evans, M.A., B.J. Wilson and R.D. Harbison. Toxicity and mutagenic effects of Rubrat.oxin B. American Society of Pharmacology o id Experi mental Therapeutics. University of California, Davis, California, 1975. 31. MacDonald, J.S., R.D. Harbison, T.H. Pratt and M.M. Jones. Synthesis and pharmacological study of some new metal chelators. Society of Toxicology, Atlanta, Georgia, March, 1976. 32 Evans, M.W., C. Dwivedi and R.D. Harbison. Comparison of the toxicity of Rubratoxin B and its dihydro analog. Society of Toxicology. Atlanta, Georgia, 1976. 33. Evans, M.A., A.S. Nies, J.T. Watson and R.D. Harbison. Glutethimide poisoning: Identification and possible role of 4 hydroxy-2-ethyl-2pfenyl-glutarimide in patient morbidity. American Academy of Forensic Sciences, Washington, D.C. 1976. 34. Evans, M.A., G. Atwood and R.D. Harbison. The pharmacokinetics of meperidine in newborn infants. American Society for Clinical Pharma cology, New Orleans, LA, 1976. URL 07. ro Ei 21 35. Harbison, R.D. and B. Mantilla-Plata. Alteration of delta-9tetrahydro-cannabinol induced teratogenesis. Society of Toxicology, Atlanta, GA, March, 1976. 36. Harbison, R.D., M.W. Stevens and C. Dwivedi. Regulation of fetal growth by a placental cholinergic system. Federation of American Society for Experimental Biology, 1976. 37. Evans, M.S., C. Dwivedi, W.J. Hayes and R.D. Harbison. Paradoxical enhancement of cocaine-induced lethality by phenobarbital. Federation of American Society for Experimental Biology, 1976. 38. MacDonald, J.S. and R.D. Harbison. Concentrations of inorganic and organic mercury in mouse brain associated with varying degrees of neuropathology and functional impairment. Society of Toxicology, Toronto, Canada, 1977. 39. Fant, M. and R.D. Harbison. The human placental cholinergic system: A model for examining its role in placental function. Society of Toxicology, Toronto, Canada, 1977. 40. Dwivedi, C., D.N. Singh, E.P. Crump and R.D. Harbison. Reproductive toxicity of cadmium. Society of Toxicology, Toronto, Canada, 1977. 41. Freeman, R.W., R.L. Woosley and R.D. Harbison. In vitro and in vivo testing for reactive metabolites of cocaine and procainamide. Society of Toxicology, 1977. 42. Freeman, R.W., R.D. Harbison, R.L. Woosley and J.A. Oates. A proposed reactive metabolite of procainamide in procainamide-induced systemic lupus erythematosis. Federation Proceedings. 36, 971, 1977. 43. Olson, R.D., J.S. MacDonald, R.D. Harbison, C.J. Van Boxtel, R.C. Boerth and J.A. Oates. Altered myocardial glutathione levels: A possible mechanism of adriamycin toxicity. Federation Proceedings. 36, 303, 1977. 44 Fant, M.E. and R.D. Harbison. Identification of membrane associated cholinergic system in human placental and spermatozoa. Federation Proceedings. 36, 1034, 1977. 45. Vansant, J.P., R.M. Woosley, J.T. John, J.A. Oates, R.D. Harbison and J.S. Sergent. The acetylator phenotype of patients with SI.E. XIV International Congress of Rheumatology, San Francisco, California, July 1977. 46. Harbison, R.D., J.S. MacDonald, B.J. Sweetman and D. Taber. Proposed mechanism for diphenylhydantoin-induced teratogenesis. The Pharma cologist. 19, 1977. URL 07 ^ 22 URL 07 47. Harbison, R.D. Chemical-biological reactions cofrmon to mutagenesis and teratogenesis. Society of Toxicology Target Organ Symposium, Nashville, TN, 1977. 48. Freeman, R.W. and R.D. Harbison. Cocaine-induced hepatic necrosis. Society of Toxicology, San Francisco, California, March, 1978. 49. Rubel, B.L., J.S. MacDonald, R.D. Harbison, M.M. Jones, T. Pratt and W. Mitchell. Synthesis and study of some new chelating agents which stimulate the bi1' ry excretion of methyl mercury. Society of Toxicology, San Fiancisco, California, March, 1978. 50. Freeman, R.W., 0.$. MacDonald, R.C. Boerth, R.D. Harbison and J.A. Oates. Studies of the effect of sulfhydryl reagents on the antitumor effect of adriamycin. Society of Toxicology, San Francisco, California, March, 1978. 51. Fant, M. and R.D. Harbison. Interaction of cholinergic ligands with plasma membrane from human term placentae. Federation American Society Experimental Biology, Atlantic City, New Jersey, April, 1978. 52. Freeman, R.W. and R.D. Harbison. Norcocaine-induced hepatic necrosis. Pharmacologist, 20(3):193, 1978. 53. Wells, P.G., R.C. Boerth, J.A. Oates and R.D. Harbison. Toxicologic enhancement by combinations of drugs which deplete glutathione. Seventh International Congress of Pharmacology, Paris, France, July, 1978. 54. Smith, A.C., R.W. Freeman and R.D. Harbison. Ethanol potentiation of cocaine-induced hepatic necrosis. Toxicology and Applied Pharma cology, 48:A141, 1979. 55. Freeman, R.W., R.l. Woosley, J. Uetrecht, J.A. Oates and R.D. Harbison. In vitro and _in vivo convalent binding of procainamide to hepatic protein in mice. Pharmacologist, 21(3):221, 1979. 56. Goodman, D.R., M.E. Fant and R.D. Harbison. Direct effects of the heavy metals mercury and cadmium on alpha aminoisobutyric acid trans ported across human placental membranes. Federation of American Society of Experimental Biology, Dallas, Texas, April, 1979. 57. Smith, A., R. James, l. Berman and R.D. Harbison. Studies of the possible mechanisms of triodothyronine enhancement of halothaneinduced hepatic necrosis. Society of Toxicology, Washington, D.C., March, 1980. 58. James, R., B. Jernigan and R.D. Harbison. Depletion of mouse hepatic glutathione by the MI complex forming compound LAAM, nor-LAAM, SKF 525A and pipcronyl butoxide. Federation of American Society for Experimental Biology, Anaheim, California, April, 1980. 23 URL 07224 59. James, R., R. Freeman and R.D. Harbison. 1-Alpha acetylmethadolinduced hepatotoxicity. Second International Congress on Toxicology. Brussels, Belgium, 1980. 60 Smith, A., R. James, L. Berman and R.D. Harbison. Relationship of glutathione to halothane-induced liver injury in the hyperthyroid rat. Second International Congress on Toxicology, Brussels, Belgium, 1980. 61. Goodman, D.R. and R.D. Harbison. Inhibition of alpha-aminoisobutyric acid (AIB) across human placental membranes by several membrane active compounds. Society of Toxicology, Washington, D.C., March 1980. 6?. Goodman, D.R. and R.D. Harbison. A *y1ation activity in rat sperm. Federation American Society Experi al Biology, Anaheim, California, April, 1980. 63. Goodman, D.R. and R.D. Harbison. Inhibition of choline acetyl trans ferase and carnitine acetyl transferase by cadmium and mercury. American Society for Pharmacology and Experimental Therapeutics, Rochester, Minnesota, August, 1980. 64. James, R.C., D.R. Goodman, S. Harper and R.D. Harbison. Depletion of mouse hepatic glutathione by the narcotic compounds propoxyphene and morphine. The Toxicologist. 1(1):330, March 1981. 65. Jernigan, J.D. and R.D. Harbison. Induction of hepatic mixed function oxygenases by 2,5-hexanedione in male mice. The Toxicologist. 1(1):358, March 1981. 66. Jernigan, B.R., M.M. Jones and R.D. Harbison. Synthesis and pharma cological study of the metal chelator N-propionyl-D, L-penicllamine (NPPA). The Toxicologist. 1(1}:435, March 1981. 67. Wells, P.G., A. Kupfer, J.A. Lawson and R.D. Harbison. Steroselective dissociation of hydantoin fetal toxicology from maternal pharmacologic activity in mice: Evaluation of mephenytoin and its metabolite, nirvanol. The Toxicologist. 1(1):534* March 1981. 68. Roberts, S.M., V.R. Grund, R.C. James and R.D. Harbison. Examination of the potential role of histamine in morphine-induced hepatic gluta thione depletion. The Pharmacologist 24(3):191, 1982. 69. Goodman, D., F. Adatsi, S. Ali, and R. Harbison. Evidence for the nonexistence of choline acetyl transferase (ChAc) in human sperm: A case of mistaking carnitine acetyl transferase (CarAc) for ChAc. The Pharmacologist 24(3):238, 1982. 70. Jernigan, J.O., J.G. Pounds and R.D. Harbison. Potentiation of chlor inated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat liver parenchymal cells. The Toxicologist 2(1):37, 1982. 24 71. James, R.C., S.M. Roberts and R.D. Harbison. Depletion of mouse hepatic glutathione by selected endogenous compounds. The Toxicologist 2{1):183, 1982. 72. -Teaf, C.M., R.W. Freeman and R.D. Harbison. Cocaine-induced hepatotoxicity: Lipid peroxidation as a possible mechanism. The Toxicologist 3(1):95, 1983. 73. Jernigan, O.D. and R.D. Harbison. Structure-activity studies on ketone-induced potentiation of haloc^rbon hepatotoxicity in mice. The Toxicologist 3(1):101, 1983. 74. Jernigan, J.D., S. Jarmer, J.G. Pounds and R.D. Harbison. Effect of metabolic inhibitors on 2,5-hexanedione-induced potentiation of halocarbon toxicity in primary cultures of adult rat hepatocytes. The Toxicologist 3(1):156, 1983. 75. El-Sewedy, S.M. and R.D. Harbison: The role of seminal plasma glutathione in heavy metal-induced spermatotoxicity. IUTOX, San Diego, CA, August, 1983. 76. Adatsi, F.K., D.R. Goodman and R.D. Harbison: Characterization of carnitine acetyltransferase (CarAc) in male reproductive tissues. The Pharmacologist 25(3):?29, 1983. 77. Teaf, C.M. and R.D. Harbison: Effect of cadmium and buthionine sulfoximine (BSO) on glutathione levels in the male reproductive tract. The Toxicologist 4(1):44, 1984. 78. Schiefer, M., R.D. Harbison, J.G. Pounds and R.C. James: The protective effects of alpha2~adrenergic blockers on the hepatotoxicity of cocaine. The Toxicologist 4(1):317, 1984. 79. Jarmer, S., A.R. Shoaf and R.D. Harbison: A study of the heterogenicity of acetylating enzymes in human placental syncytiotrophoblast vesicles and inhibiting effects of HgC12 CdC 12 and CH3HgCl. Fed. Proc. 43(3):577, 1984. 80. Adatsi, F.K., R.C. James and R.D. Harbison: Possible involvement of a carnitine acetyltransferase system in trimethyl phosphate-induced sterility. Fed. Proc. 43(3):656, 1984. 81. Adatsi, F., James, R.C. and R.D. Harbison: The potential role of the carnitine acetylt:. sferase system in cadmium-induced sterility of male Fischer 344 t i.s. The Toxicologist 5(1); 140, 1985. 82. Shoaf, A.R., R.D. Harbison and A. Shaikh. Model reactions of superoxide radical anions ('O^) in aprotic media. The Toxicologist 5(1): 213, 1985. 25 URL 07225 I1 URL 07226 83. Teaf, C.M., J.B. Bishop and R.O. Harbison. Ethylene dibromide (EDB) and buthionine sulfoximine (BSO) potentiation of ethyl methanesulfonate (EMS) induced dominant lethal mutations. The Toxicologist 5(1):140, 1985. 84. Teaf, C.M., J.B. Bishop and R.D. Harbison. Glutathione and the potentiation of ethylmethanesulfonate (EMS) induced germ cell mutagenesis by ethylene dibromide (EDB) and buthionine sulfoximine (BSO). Environmental Mutagenesis 8{Suppl. 6):85, 1986. 85. Mi liner, G.C., J. Gandy, 0. Casciano and R.D. Harbison. The effect of selected chemicals on glutathione (GSH) levels in the male reproductive tract. The Toxicologist 6(1):290, 1986. 86. Adatsi, F.K., R.C. James and R.D. Harbison. Possible mechanism and locus of ethylene dibromide (EDB)-induced sterility in male Fischer 344 rats. The Toxicologist 6(1):31, 1986. 87. Gandy, J., C.M. Teaf, F.A. Adatsi and R.D. Harbison. The dependence of male reproductive toxicity on germ cell stage. Presented at the Satellite Symposium of the Fourth International Congress of Toxicology, Tokyo, Japan, July 1986. 88. Kerger, B.D., R.D. Harbison, T.J. Bucci, R.C. James and J. Gandy. Antagonism of Bromobenrene-induced hepatotoxicity by the adrenergic blocking agent, phentolamine. The Pharmacologist 28(3):180, 1986. 89. Quirk, J.G. Jr., C. Miller, R. Harbison, B. Butler, and L. Keppen. Maternal serum alpha-fetoprotein (MSAFP) screening for fetal aneuoploidy. To ' presented at the Society for Gynecologic Investigation, 1987. 90. Millner, G., J. Shaddock, R.D. Harbison and D.A. Casciano. Comparative evaluation of unscheduled DNA synthesis (UDS) in hepatocytes isolated from various mouse strains. To be presented at the Environmental Mutagen Society, 1987. 26 i CURRICULUM VITAE Robert William Kellermeyer BORN: September 4, 1929; Wheeling, WV SS #: 232*38-8173 FAMILY: Wife, Audrey S. CHILDREN: Suzanne, May 16, 1959 Scott, March 29, 1962 Mark, April 2, 1966 HOME ADDRESS: 33000 Fairmount Boulevard Cleveland, Ohio 44124 OFFICE ADDRESS: University Hospitals of Cleveland Cleveland, Ohio 44106 EDUCATION: 1951, B.A., Washington and Jefferson College 1955, M.D., Western Reserve University PROFESSIONAL APPOINTMENTS: URL 07227 Internship, Department of Medicine, University Hospitals, Western Reserve University, 1955-56. Assistant Resident, Department of Medicine, University Hospitals, Western Reserve University, 1956-57. Research Associate, Department of Medicine, University of Chicago, 1957-59. Postdoctoral Fellow of the American Cancer Society in the Department of Biochemistry, Western Reserve University, 1959-62. Assistant Physician, University Hospitals, Western Reserve University, 1961-67. Chief Resident, Department of Medicine, University Hospitals, Western Reserve University, 1962-63. Instructor, Department of Medicine, Western Reserve University, 1963-65. Senior Instructor, Department of Medicine, Western Reserve University, 1965-66. Assistant Professor, Department of Medicine, Case Western Reserve University, 1965-68. Assistant Director, Experimental Training Grant, Department of Medicine, Western Reserve University, 1966. Physician-in-Charge, Special Hematology Laboratory, University Hospitals, Western Reserve University, 1967-77. Phys^ rian/Attending/Hematology, Cleveland Veterans Admi tration Hospital, 1965- Director, Division of Clinical Pharmacology, Case Western Reserve University, 1969-74. Associate Professor, Department of Medicine, Case Western Reserve University, 1969-75. Associate Professor, Department of Pharmacology, Case Western Reserve University, 1969-77. Co-Director, Division of Hematology, University Hospitals of Cleveland, Case Western Reserve University, 1974-83 Professor, Department of Medicine, Case Western Reserve University, 1975- David and Inez Myers Professor of Hematology, Dei .tment of Medicine, Case Western Reserve University, 1978- Director, University Hospitals Ambulatory Oncology Center, 1979- PROFESSIONAL APPOINTMENTS: Chairman, Hematology Subject Committee, 1968-1969, 1975-1976 Cleveland Academy of Medicine, 1969Member, Southeastern Cancer Study Group, 1973Chairman, Oncology Council, 1978Chairman, American Cancer Society Institutional Grant Committee, 1978-1980 Member, Cancer Control Consortium of Ohio, 1979' Member, Board of Directors, Ohio Valley Lake Erie Association of Cancer Centers CERTIFICATION: American Board of Internal Medicine, Internal Medicine (1964) American Board of Internal Medicine, Hematology (1974) American Board of Internal Medicine, Oncology (1979) x G ro co MILITARY DUTY AND STATUS: Senior Assistant Surgeon, U.S. Department of Health, Education and Welfare, National Institutes of Health, stationed with Army Medical Research Unit, Stateville Penitentiary, Joliet, Illinois, 1957-59. Present status: Senior Assistant Surgeon (R), inactive AWARDS: 1951 - Edward S, Linton Prize in Biology, Washington and Jefferson College 1965 - John and Mary R. Markle Scholar in Academic Medicine 1966 - Career Development Award, U.S. Public Health Service 1982 - American Cancer Society, Professor of Clinical Oncology HONORARY SOCIETIES: Phi Beta Kappa Sigma Xi Alpha Omega Alpha , URL 07229 SOCIETIES: American Federation for Clinical Research American Association for Advancement of Science American Society of Hematology Central Society for Clinical Research American Association for Cancer Education American Society for Clinical Oncology American College of Physicians Northeast Ohio Society of Clinical Oncology COMMUNITY SERVICE: Board of Trustees, Cancer Data System, 1981- Professional Education Committee, Ohio Division, American Cancer Society Pilot Research Committee, Ohio Division, American Cancer Society Medical Advisory Committee, Cuyahoga County, American Cancer Society Board of Trustees, Ohio Division, American Cancer Society, 1984Pilot Research Committee, Cancer Consortium of Ohio, 1980- URL 07230 PUBLICATIONS: 1. Kellermeyer, R.W.: Mechanical Fragility of Erythrocytes from Patients with Paroxysmal Nocturnal Hemoglobinuria. Proc. Soc. Exp. Biol. Med. 91:157-160, 1956. 2. Schrier, S.L., Kellermeyer, R.V., Carson, P.E., Ickes, C.E., and Alving, A.S.: The Hemolytic Effect of Primaquine: IX. Enzyma tic Abnormalities in Primaquine-Sensitive Erythrocytes. J. Lab. Clin. Med. 52:109-117, 1958. 3. Alving, A.S., Kellermeyer, R.W., Tarlov, A., Schrier, S., and Carson, P.E.s Biochemical and Genetic Aspects of PrimaquineSensitive Hemolytic Anemia. Ann. Int. Med. ,49:240-248, 1958. 4. Schrier, S.L., Kellermeyer, R.W., and Alving, A.S.: Coenzyme Studies in Primaquine-Sensitive Erythrocytes. Proc. Soc. Exp. Biol. Med, 99:354-356, 1958. 5. Alving, A.S., Rucker, K., Flanagan, C.L., Carson, P.E., Schrier, S.L., Kellermeyer, R.W., and Tarlov, A.R.: Observations on Primaquine in the Prophylaxis and Cure of Vivax Malaria. Proc. 6th Int. Congr. Trop. Med. and Malar. 7*203-209, 1959. 6. Carson, P.E., Schrier, S.L., and Kellermeyer, R.W.: Mechanism of Inactivation of Glucose-6-Phosphate Dehydrogenase in Human Erythrocytes. Nature 184:1292-1293, 1958. 7. Schrier, S.L., Kellermeyer, R.W., Carson, P.E., Ickes, C.E., and Alving, A.S.: The Hemolytic Effect of Primaquine: X. Aldolase and Glyceraldehyde-3-Phosphate Dehydrogenase Activity in Primaquine-Sensitive Erythrocytes. J. Lab. Clin. Med. 54:232-240, 1959. 8. Alving, A.S., Johnson, C.F., Tarlov, A.R., Brewer, G.J., Kellermeyer, R.W., and Carson, P.E.: Mitigation of the Haemo lytic Effect of Primaquine and Enhancement of its Action against Exoerythrocytic Forms of the Chesson Strain of Plasmodium Vivax by Intermittent Regimens of Drug Administration. Bull. Wld. Hlth. Org. 22:621-631, 1960. 9. Alving, A.S., Tarlov, A.R., Brewer, G., Carson, P.E., Kellermeyer, R.W., and Long, W.K.: Glucose-6-Phosphate Dehydro genase Deficiency: Some Biological Implications. Trans. Assoc. Am. Phys. 78:80-92, 1960. 10. Tarlov, A.R., and Kellermeyer, P w.: The Hemolytic Effect of Primaquine: XI. Decreased Catalase Activity in PrimaquineSensitive Erythrocytes. J. Lab. Clin. Med, ,58:204-216, 1961. 11. Brewer, G.J., Tarlov, A.R., and Kellermeyer, R.W.: The Hemolytic Effect of Primaquine: XII. Shortened Erythrocyte Life Span in Primaquine-Sensitive Male Negroes in the Absence of Drug Administration. J. Lab. Clin. Med. .58:217-224, 1961. URL 07231 12. Kellermeyer, R.W. , Tarlov, A.R., Schrier, S.L., Carson, P.E., and Alving, A.S.: The Hemolytic Effect of Primaquine: XIII. Gradient Susceptibility to Hemolysis of Primaquine-Sensitive Erythrocytes. J. Lab. Clin. Med. ,58:225-233, 1961. 13. Kellermeyer, R.W., Carson, P.E., Schrier, S.L., Tarlov, A.R., and Alving, A.S.: The Hemolytic Effect of Primaquine: XIV. Pentose Metabolism in Primaquine-Sensitive Erythrocytes. J. Lab. Clin. Med. 58:715-724, 1961. 14. Brewer, G.J., Tarlov, A.R., Kellermeyer, R.W., and Alving, A.S.: The Hemolytic Effect of Primaquine: XV. Role of Methemoglobin. J. Lab. Clin. Med. ,59:905-917, 1962. 15. Kellermeyer, R.W., Tarlov, A.R., Brewer, G.J., Carson, P.E., and Alving, A.S.: Hemolytic Effect of Therapeutic Drugs: Clinical Considerations of the Primaquine-Type Hemolysis. JAMA 180:388-394, 1962. 16.. Rose, I.A., Kellermeyer, R.W., Stjernholm, R., and Wood, H.G.: ''The Distribution of C14 in Glycogen from Deuterated Glycerol-C14 as a Measure of the Effectiveness of Triosephophate Isomerase in vivo. J. Biol. Chem. .237:3325-3331, 1962. 17. Kellermeyer, R.W., and Wood, H.G.: Methylmalonyl Isomerase: A Study of the Mechanism of Isomerization. Biochem. 1:1124-1131, 1962. 18. Allen, S.H.G., Kellermeyer, R.W., Stjernholm, R., Jacobson, B., and Wood, H.G.: The Isolation, Purification, and Properties of Methylmalonyl Racemase. J. Biol. Chem. 238:1637-1642, 1963. 19- Kellermeyer, R.W., Allen, S.H.G., Stjernholm, R., and Wood, H.G.: Methylmalonyl Isomerase: IV. Purification and Properties of the Enzyme from Propionibacteria. J. Biol. Chem. 239:2562-2569, 1964. 20. Allen, S.H.G., Kellermeyer, R.W., Stjernholm, R.L., and Wood, H.G.: Purification and Properties of Enzymes Involved in the Propionic Acid Fermentation. J. Bacterid. .87:171-187, 1964. 21. Wood, H.G., Kellermeyer, R.W., Stjernholm, R., and Allen, S.H.G.: Metabolism of Methylmalonyl-CoA and the Role of Biotin and B22 Coenzymes. Ann. N.Y. Acad. Sci. 112:661-679, 1964. 22. Breckenridge, R.T., and Kellermeyer, R.W.: A Hemorrhagic Syndrome Due to Dicumarol Poisoning Masquerading as Propyl thiouracil Sensitivity. Ann. Int. Med. .60:1066-1068, 1964. 23. Kellermeyer, R.W., and Breckenridge, R.T.: The Inflammatory Process in Acute Gouty Arthritis: I. Activation of Hageman Factor by Sodium Urate Crystals. J. Lab. Clin. Med. 65:307-315, 1965. .24 Kellermeyer, R.w., and Breckenridge, R.T.: The Inflammatory Process in Acute Gouty Arthritis: II. The Presence of Hageman Factor and Plasma Thromboplastin Antecedent in Synovial Fluid. J. Lab. Clin. Med. 67:455-460, 1966. 25. Kellermeyer, R.W.: Inflammatory Process in Acute Gouty Arthritis: III. Vascular Permeability-Enhancing Activity in Normal Human Synovial Fluid; Induction by Hageman Factor Activators and Inhibition by Hageman Factor Antiserum. J. Lab. Clin. Med. 70:372-383, 1967. 26. Kellermeyer, R.W., and Ratnoff, O.D.: Abolition of the Permeability-Enhancing Properties of Hageman Factor by Specific Antiserum. J. Lab. Clin. Med. 70:365-371, 1967. 27. Kellermeyer, R.W.: Hageman Factor and Acute Gouty Arthritis. Arth. & Rheum. 11:452-459, 1968. 28. Allen, S.H.G., Kellermeyer, R.W., and Wood, H.G.: Methylmalonyl-CoA Racemase from Propionibacterium shermanii in Methods in Enzymology XIII. Citric Acid Cycle, ed. J.M. Lowenstein, Academic Press, New York, p. 194. 29. Kellermeyer, R.W., and Wood, H.G.: 2-Methylmalonyl-CoA Mutase from Propionibacterium shermanii (Methylmalonyl-CoA Isomerase) Methods in Enzymology XIII, Citric Acid Cycle, ed. J.M. Lowenstein, Academic Press, New York, p. 207. 30. Graham, R.C., Jr., and Kellermeyer, R.W.: Bovine Lactoperoxidase as a Cytochemical Protein Tracer for Electron Microscopy. J. Histochem. Cytochem. ^16:275-278, 1968. 31- Graham, R.C., Jr., Limpert, S.# and Kellermeyer, R.W.: The Uptake and Transport of Exogenous Proteins in Mouse Liver: Ultrastructural Cytochemical Studies with Peroxidase Tracers. Lab. Invest. 20:298-304, 1969. 32. Kellermeyer, R.W., and Graham, R.C., Jr.: Kinins: Possible Physiologic and Pathologic Roles in Man. N. Eng. J. Med. 279:754-759, 802-807, 859-866, 1968. 33. Kellermeyer, W.F., Jr., and Kellermeyer, R.W.: Activation of Hageman Factor by Cellulose Sulfate Solutions. Proc. Exp. Biol. Med. 130:1310, 1969. 34. Schwartz, H., and Kellermeyer, R.W.: Activation of Hageman Factor by Cellulose Sulfate Solutions. Proc. Exp. Biol. Med. 1'*' : 1310, 1969. 35. Kellermeyer, R.W., and Warren, K.S.: The Role of Chemical Mediators in the Inflammatory Response Induced by Foreign Bodies: Comparison with the Schistosome Egg Granuloma. J. Exp. Med. 131:21, 1970. URL 07232 URL 07233 36. Stjernholm, R.L., Noble, E.P., Dimitrov, N.V., and Kellermeyer, R.w. : Differentiation of Normal and Leukemic Leukocytes into Three Groups by propionate Metabolism. J. Reticuloendothelial Soc. 8:446-457, 1970. 37. Burns, C.P., Stjernholm, R.L., and Kellermeyer, R.W.: Hodgkin's Disease Terminating in Acute Lymphosarcoma Cell Leukemia - A Metabolic Study. Cancer 22*806, 1971. 38. Cook, J.A., Kellermeyer, W.F., Jr., Warren, K.S., and Kellerneyer, R.W.: Sickle Cell Hemoglobinopathy and Schistosomiasis Mansoni. Ann. Trop. Med. and Parasitol. 66:197, 1972. 39. Byers, P., Ward, P., Kellermeyer, R.W., and Naff, G.: Comple ment as a Mediator of Inf lamination in Acute Gouty Arthritis. II. Biological Activities Generated from Complement by the Interaction of Serum Complement and Sodium Urate Crystals. J. Lab. Clin. Med. 81:761, 1973. 40. Kellermeyer, R.W., Warren, K.S,. Waldman, T.A., Cook, J.A., and Jordan, P.: Serum Immunoglobulin Concentrations in St. Lucians with Schistosomiasis Compared with Matched Uninfected St. Vincentians. J. Infec. Dis. 127:557, 1973. 41. Warren, K.S., Kellermeyer, R.W., Jordan, P., Littel, A.S., Cook, J.A., and Kagan, I.G.: Immunologic Diagnosis of Schistosomiasis I. A Controlled Study of Intradermal (immediate and delayed) and Serologic Tests in St. Lucians Infected with Schistosomiasis mansoni and in Uninfected St. Vincentians. Am. J. Trop. Med. Hyg. .22:189-198, 1973. 42. Ham, T.H., Grauel, J.A., Dunn, R.F., Murphy, J.R., .White, J.G., and Kellermeyer, R.w.: Physical Properties of Red Cells as Related to Effects In Vivo IV. Oxidant Drugs Producing Abnor mal Intracellular Concentration of Hemoglobin (eccentrocytes) with Rigid-Red Cell Hemolytic Syndrome. J. Lab. Clin. Med. 82:898-910, 1973. 43. Mahmoud, A.A.F., Kellermeyer, R.W,, and Warren, K.S.: Produc tion of Monospecific Rabbit Antihuman Eosinophil Sera with Demonstration of a Blocking Phenomenon. N. Eng. J. Med. 290:417, 1974. 44. Cru, E.D., Ng, A.B.P., Tsoa, L., Kellermeyer, R.W.: Hodgkin's Disease: Survival and Histologic Classification in a General Medical Center, 1952-1971. Am J. Clin. Path. .61:403, 1974. 45. Murphy, J.R., Wengerd, M., and Kellermeyer, R.W.: Erythrocyte O2 Affinity: Influence of Cell Density and _r n Vitro Changes in Hemoglobin Concentration. J. Lab. Clin. Med. 62:218, 1974. 46. Mahmoud, A.A.F., kellermeyer, R.W., and Warren, K.S.: Monospecific Antigranulocyte Sera Against Human Neutrophils, Eosinophils, Basophils, and Myeloblasts. Lancet, 2J1163-1166, 1974. URL 07234 4*7. Ross, C.E., Muir, W.A., Ng, A.B.P., Graham, R.C., Jr., and Kellermeyer, R.W.: Hemochromatosis: Pathologic and Genetic Considerations. Amer. J. Clin. Path. 3:179, 1979. 48. Conomy, J.P., and Kellermeyer, R.W.: Delayed Cerebrovascular Consequences of Therapeutic Radiation: A Clinicopathologic Study of Strokes Due to Radiation-Related Carotid Arteriopathy. Cancer 36:1702-1708, 1975. 49. Ross, C.E., Stone, M.K., Reagan, J.W., Wentz, W.B., and Kellermeyer, R.W.: The Influence of Oral Contraceptives on Serum Folate, Hematologic Values and Uterine Cervical Cytology. Seminars in Hematology, Vol. 13, July, 1975. 50. Kellermeyer, R.W. and Naff, G.B.: Chemical Mediators of Inflam mation in Acute Gouty Arthritis. Arth. & Rheum. 1, No. 6 (suppl) pp. 765-770, 1975. 51. Wine, A.C., and Kellermeyer, R.: A Computer Based Method for the Quantification of Leukocyte Chemotaxis. J. Lab. and Clin. Med. 88:487, 1976. 52. Mahmoud, A.A.F., Stone, M.K., Kellermeyer, R.W.: Eosinophilopoietin: A Circulating Low-Molecular Weight Peptide-Like Substance which Stimulates the Production of Eosinphils in Mice. J. Clin. Invest. <50:675-682, 1977. 53. Mahmoud, A.A.F., Stone, M.K., Kellermeyer, R.W.: Eosinophilo poietin: A Low Molecular Weight Peptide Stimulating Eosinophils in Mice. Trans. Assoc. Am. Physicians 90:127-134, 1977. 54. Griffin, J.P., Druet, R.L., Sheehan, W.W., Kellermeyer, R.W.: Evaluation of Reactive Hyperplasia to Immunoblastic Lymphadenopathy to Immunoblastic Sarcoma. In preparation. 55. Vicic, W., Beck, S., Rosenblatt, J., Kellermeyer, R.W.: Hodgkin's Disease: Improved Survival in a General Medical center, 1952-1976. In preparation. 56. McLaren, G.D., Goldsmith, G.H., Fersky, p.A. and Kellermeyer, R.W.: Effect on Erythropoiesis of Increased Serum Folate Binding Proteins (FBP) and Undetectable "Free" Folate. Submitted for publication. 57. Lazarus, H.M., Kellermeyer, R.W., Aikawa, M., Herzig, R.H.: Multiple Myeloma in Young Men: Clinical Course and Electron Microscope Studies of Bone Marrow Plasma Cells. Cancer 46:1397, 1980. 58. Perez, C.A., Krauss, S., Bartolucci, A.A., Durant, J.R., Lowenbraun, S., Salter, M.M., Storaasli, J., Kellermeyer, R.W. and Comas, F.: Thoracic and Elective Brain Irradiation with Concomitant or Delayed Multiagent Chemotherapy in the Treatment of Localized Small Cell Carcinoma of the Lung. A randomized prospective study by the Southeastern Cancer Study Group. Cancer 47:2407-2413, 1981. (SEG 76 LUN 307). 59. Perez, C.A., Einhorn, L., Oldham, R.K., Greco, F.A., Cohen, H.J., Silberrnan, H.r Krauss, S., Hornback, H., Comas, F., Omura, G., Salter, M., Keller, J.W., McLaren, K, Kellermeyer, R.W., Storaasli, J., Birch, R., Dandy, M.: Randomized Trial of Radiotherapy for the Thorax in Limited Small Cell Carcinoma of Lung Treated with Multiagent Chemotherapy and Elective Brain Irradiation. A Preliminary Eeport. J. Clin. Oncol, vol. 2, 1200-1206, July-December, 1984. 60. Gams, R.A., Omura, G.A., Valez-Garcia, E., Kellermeyer, R.W., Raney, M., Bartolucci, A.A.: Alternating Seguential Combination Chemotherapy in the Management of Advanced Hodgkin's Disease. A Southeastern Cancer Study Group Trial. Cancer 58:1963-1968, 1986. URL 07235 ABSTRACTS: 1. Schrier, S., Kellermeyer, R.W., Carson, P., and Alving, A.S.: A Second Enzyme Abnormality in Primaquine Sensitive Erythrocytes, J. Lab. Clin. Med. .50:951, 1957. 2. Kellermeyer, R.W., Tralov, A.R., Schrier, S.L., and Alving, A.S.j Hemolytic Effect of Commonly Used Drugs on Erythrocytes Deficient in Glucose-6-Phosphate Dehydrogenase. J.'Lab. Clin. Med. 52:827, 1958. 3. Carson, P.E., Alving, A.S., Schrier, S.L., Kellermeyer, R.W., Flanagan, C.L., and Tarlov, A.R.: Biochemical Abnormalities in Primaquine-Sensitive Erythrocytes. Abstracts, 134th Meeting Am. Chem. Soc. 3D, 1958. 4. Schrier, S.L., and Kellermeyer, R.W.: Compensatory Mechanisms in Primaquine-Sensitive Erythrocytes. J. Clin. Invest. 37:928, 1958. 5. Kellermeyer, R.W., Tarlov, A.R., Schrier, S.L., and Carson, P.E.: Dosage-Response Studies During the Resistant Phase in Primaquine-Sensitive Hemolytic Anemia. J. Clin. Invest. 28^:1016, 1959. 6. Tarlov, A.R., and Kellermeyer, R.W.: Decreased Catalase Activity in Primaquine-Sensitive Erythrocytes. Fed. Proc. 18:619, 1959. 7. Tarlov, A.R., Brewer, G.J., and Kellermeyer, R.W.: The Effect of Drug Induced or Blood Loss Anemia on the Biochemical Compo sition of Normal and Primaquine-Sensitive (G-6-PD Deficient) Reticulocytes. Submitted to Am. Soc. of Hematology, 1960. 8. Brewer, G.J., Tarlov, A.R., and Kellermeyer, R.W.: Role of Methemoglobin in the Mechanism of Drug Induced Hemolysis Associated with Glucose-6-Phosphate Dehydrogenase Deficiency. J. Lab. Clin. Med. 56:796' i960. 9. Rose, I.A., Kellermeyer, R.W., Stjernholm, R., and Wood, H.G.: Evidence for the Non-Equilibration of Triose-Phosphates in the Synthesis of Liver Glycogen. Fed. Proc. 0:226, 1961. 10. Allen, S.H.G., Wood, H.G., Stjernholm, R., and Kellermeyer, R.W. : Separation and Purification of Methylmalonyl CoA Racemase and Isomerase from Propionic Acid Bacteria. Fed. Proc. 21:244, 1962. 11. Allen, S.H.G., Kelelrmeyer, R.W., Stjernholm, R., and Wood, H.G.: Partial Reconstruction of the Propionic Acid Fermentation with Purified Enzymes. Fed. Proc. 22.:, 1963. URL 07236 URL 07237 12. Kellermeyer, R.W., and Breckenridge, R.T.: Activation of Hageman Factor by Monosodium Urate Crystals: A Proposed Mechanism for the Initiation of Acute Gouty Arthritis. J. Lab. Clin. Med. 64:873, 1964. 13. Kellermeyer, R.W.: Mechanism of Inf lamination in Acute Gouty Arthritis: Activation of Permeability Factor Activity in Syno vial Fluid by Urate Crystals. 0. Lab. Clin. Med. 6J3 :887, 1966. 14. Warren, K.# and Kellermeyer, R.W.: Foreign Body Granuloma as a Response to Chemical Mediators of Inflammation. J. Clin. Invest. 42:99a, 1968. 15. Burns, P.C., Stjernholm, R., and Kellermeyer, R.W.: Metabolic Abnormalities in Infectious Mononucleosis. Clin. Res. 18-:400, 1970. 16. Mahmoud, A., Kellermeyer, R., Warren, K.S.: Production of .Monospecific Rabbit Antihuman Eosinophil Sera. Am. J. Trop. Wed., 1973. 17. Conomy, J.P., and Kellermeyer, R.w.: Delayed Cerebrovascular Consequences of Therapeutic Radiation: A Clinicopathologic Study of Strokes Due to Radiation-Related Cervical Carotid Arteritis. Neurology, 1974 (in press). 18. Mahmoud, A.A.F., Kellermeyer, R.w., and Warren, K.S.: Monospeci fic Human Anti-Neutrophil and Anti-Eosinophil Sera. J. Clin. Invest. 53:49a, 1974. 19. Ross, C.E., Kellermeyer, R.w., Reagan, J.W., and Wentz, W.B.: The Influence of Oral Contraceptives on Serum Folates and Cervical Cytology. Clin. Res. 23;:281A, 1974. 20. Mahmoud, A.A.F., Stone, M.K., Kellermeyer, R.W., and Warren, K.S.: Induction of Eosinophilopoietic Activity in Mouse Serum Following Depletion of Mature Eosinophils with a Specific Antiserum. Am. Soc. Hematology, 1975. 21. Stone, M.K., Mahmoid, A.A.F., Kellermeyer, R.W., and Warren, K.S.: Induction of Eosinophilopoietic Activity in Mouse Serum Following Depletion of Mature Eosinophils with a Specific Antiserum. Am. Soc. Hematology, 1975. 22. Wine, A.C., Polmar, S. and Kellermeyer, R.W.: A Serum Inhibitor of Chemotaxis in Job's Syndrome. Clin. Res. 2_4: April, 1976. 23. McLaren, G.D., Sachs, S.D., Muir, W.A. and Kellermeyer, R.W.: Canine Hemochromatosis: A Model for the Study of Reticulo endothelial Cell Function. Clin. Res. 234: April, 1976. 24. Mahmoud, A.A.F., Stone, M.K., Kellermeyer, R.W. and Warren, K.S.: Humoral Eosinophilopoietic Factor: Demonstration of Activity in vivo and Partial Purification. Clin. Res. 24: April, 1976. I 25. Ross, C.E., Stone, M.K., Reagan, J.W., Wentz, W.B., and Kellermeyer, R.W.: Lack of Influence of Oral Contraceptives on Serum Folate, Hematologic Values, and Uterine Crevical Cytology. Sem. Hematol. 13:233, 1976. 26. Mahmoud, A.A.F., Stone, M.D., Kellermeyer, R.W., and Warren, K.S.: Small Molecular Weight Eosinophilopoietin; Partial Characterization. Clin. Res. 2.4:571, 1976. 27. McLaren, G.D., Goldsmith, G.H., Fersky, P. and Kellermeyer, R.W.: Hematopoiesis in Patients with Zero Free Folate; Response to Folic Acid Supplementation. Clin. Res. 25:343A, April, 1977. 28. Mahmoud, A.A.F., Stone, M.K., and Kellermeyer, R.W.: Eosinophilopoietin: A Low Molecular Weight Peptide Stimulating Eosinophil Production in Mice. Clin. Res. .25:519A, April, 1977. 29. Billings, F.T., III, Kellermeyer, R.W., and Mahmoud, A.A.F.: Inhibition of Mitogen Induced DNA Synthesis of C57BL/6 Spleen Cells by Serum from Reticulum Cell Sarcoma Bearing Mice (SJL/J). Blood _50: No. 5 (Suppl 1), November, 1977. 30. Billings, F.T., III, Ellner, J.J., Kellermeyer, R.W., and Mahmoud, A.A.F.: Inhibition of DNA Synthesis by Serum of Reticulum Cell Sarcoma Bearing Mice (SJL/J). Clin. Res. 26:555A, April, 1978. 31. Mahmoud, A.A.F., Billings, F.T., III, Stone, M.K., and Kellermeyer, R.W.: Human Eosinophilopoietin. Clin. Res. 2j>: 555A, April, 1978. 32. Kedia, K.R., Kellermeyer, R.W. and Persky, L.: Hormonal Stimulation Followed by Multi-agent Chemotherapy in EstrogenUnresponsive Prostatic Adenocarcinoma. For presentation to American Urological Association, Inc., 1971 Annual Meeting, Boston, Mass. 33. Leudke, D., Leudke, S., Martello, O., Quesenberry, P., Einhorn, L., Kellermeyer, R. Birch, R., Dandy, M.: Response of Non-Small Cell Lung Cancer (NSCLC) to Vindesine (VDS) and Mitomycin C (MITO): A Southeastern Cancer Study Group Pilot Study. Proc. Am. Soc. Clin. Oncol. ,2:190, 1983. 34. Perez, C.A., Einhorn, L., Oldham, R.K., Greco, F.A., Cohen, H.J., Silberman, H., Krauss, S., Hornback, N., Comas, F., Omura, G., et al.: Randomized Trial of Radiotherapy to the Thorax in Limited Small-Cell Carcinoma of the Lung Treated with Multiagent Chemotherapy and Elective Brain Irradiation: A Preliminary Report. J. Clin. Oncol. Nov:2(ll):1200-8, 1984. URL 07238 35. Perez, C.A., Einhorn, L., Oldham, R.K., Greco, F.A., Cohen, H.J., Silberman, H. , Krauss, S., Hornback, K., Comas, F., Omura, G., Salter, M., Keller, J.W., McLaren, J., Kellermeyer, R.W,, Storaasli, J., Birch, R., Dandy, M.: Value of Radiation Therapy to the Thorax in Limited Small Cell Carcinoma of the Lung Treated with Multiagent Chemotherapy and Elective Brain Irradiation. Am. Soc. Ther. Radid. Oncol. 1984. URL 07239 -- X -- TEXT AND TEXT CHAPTERS: 1. Harris, R.W., and Kellermeyer, R.W.: The Red Cell. Harvard University Press, Revised Edition, 1971. 2. Kellermeyer, R.W.: Activation of Hageman Factor by Sodium Urate Crystals in Gout and Purine Metabolism. Ed. A.B. Gutman, Grune and Stratton, New York, pp. 741-743, 1965. 3. Kellermeyer, R.W.: Primaquine-Sensitive Hemolytic Anemia in Handbook of Clinical Laboratory Data, Edited by Faulkner, W.F., King, J.W., and Damm, H.C 2nd Edition, 1968 pp. 465-473. The Chemical Rubber Company, Cleveland, Ohio. 4. Kellermeyer, R.W.: Congenital Nonspherocytic Hemolytic Anemias in Handbook of Clinical Laboratory Data, Edited by Faulkner, W.F., King, J.W., and Damm, H.C. 2nd Edition, 1968 pp. ^74-476. The Chemical Rubber Company, Cleveland, Ohio. 5. Kellermeyer, R.W. : Drugs and G-6-PD Deficiency of Red Cells in Drugs and Hematologic Reactions, Edited by N. Dimitrov, J.H. Nodine. Grune & Stratton, New York, 1974 pp. 109-122. 6. Kellermeyer, R.W., and Schwartz, H.J.: Kinins, Basic Chemistry, Biological Action and Implication in Human Asthma, Chapter 16, in Bronchial Asthma: Mechanisms and Therapeutics. Eds. M. Segal, E.B. Weiss, Little Brown & Co., Boston, Chapter 16, pp. 217-230, 1976. 7. Wine, A.C., and Kellermeyer, R.W.: The Anemia of Chronic Disease. Continuing Education for the Family Physician, 3:49, 1975. .8 Kellermeyer, R.W.: Mastocytosis in The Science and Practice of Clinical Medicine. Grune & Stratton, New York. Submitted for publication, 1979. 9. Kellermeyer, R.W.: Eosinophilia in The Science and Practice of Clinical Medicine. Grune & Stratton, New York. Submitted for publication, 197 9. 10. Kellermeyer, R.W.: General Principles of the Evaluation and Therapy of Anemias, Medical Clinics of North America, 68:533-543, 1984. URL 07240 *"X3" BOOK REVIEWS AND LETTERS: Hematology: Physiologic, pathophysiolgic, and clinical principles. By James W, Linman, M.D., 1055 pp. New York: Macmillan, 1975. N. Engl. J. Med. 294t18):1015, 1976. Text-Atlas of Hematology: By Matthew H. Block, Ph.D., M.D. 651 pp., illustrated. Philadelpyhia: Lea and Febiger, 1976. N.-Engl. J. Med. 296(12):696, 1977. URL 07241 VIDEO-TAPED TEACHING MATERIALS: 1. Kellermeyer, R.W.: Prescription Writing, EDR Corporation, 1974. 2. Kellermeyer, R.W.: Basic Concepts of Clinical Pharmacology, EDR Corporation, 1974. 3. Kellermeyer, R.W.: Infectious Mononucleosis Complicated by Thrombocytopenia, Medical Grand Rounds, October 25, 1975, Case Western Reserve University (5020, 7102). 4. Kellermeyer, R.W.: Management of Patients with Lymphoma, Medical Therapeutics Conference, June 6, 1975, University Hospitals of Cleveland (5024). 5. Kellermeyer, R.W.: Hematologic Complications of Drug Therapy, Medical Therapeutics Conference, January 30, 1976, University Hospitals of Cleveland (5064, 7502). 6. Kellermeyer, R.W.: Angioimmunoblastic Lymphadenopathy, Medical Grand Rounds, October 2, 1976, Case Western Reserve University (5232, 7815). 7. Kellermeyer, R.W.: Heparin Induced Thrombocytopenia, Medical Grand Rounds, February 26, 1977, Case Western Reserve University (5232, 7815). 8. Kellermeyer, R.W.: Lymphoma in Transition, Medical Grand Rounds, April 30, 1977, Case Western Reserve University. 9. Kellermeyer, R.W.: Agranulocytosis Induced by Phenothazines, Medical Grand Rounds, October 29, 1977, Case Western Reserve University. 10. Kellermeyer, R.W.: Diffuse Histocytic Lymphoma, Medical Grand Rounds, November, 1977, Case Western Reserve University (Vol. 9:47). 11. Kellermeyer, R.W.: Long-term Effects of Immune Suppression, Medical Therapeutics Conference, October, 1978, University Hospitals of Cleveland, (Vol. 9:29). URL 07242 17 SOUTHEASTERN CANCER STUDY GROUP PUBLICATIONS TO WHICH PATIENT STUDIES HAVE BEEN CONTRIBUTED: 1. Smalley# R.v. and Bornstein, R. : Adriamycin, Cyclophosphamide and 5-Fluorouracil vs. Intermittent Methotrexate, 5-Fluorouracil Cyclophosphamide, Vincristine and Prednisone in Metastatic Breast Cancer. Proceedings AACR-ASCO 16:265, 1975. . 2. Durant, J.R., Gams, R.A., Bartolucci, A.A., Velez-Garcia, E., Dorfman, R.: Treatment of Hodgkin's Disease with a Five-Drug Regimen. Proceedings AACR-ASCO 16:245, 1975. 3. Knospe, W.H., Loeb, V. and Huguley, C.M., Jr.: Biweekly Chlorambucil in the Therapy of Lymphocytic Lymphoma. Proceedings AACR-ASCO 16:245, 1975. 4. Lowenbraun, S., Krauss, S., Smalley, R.V., Bartolucci, A.A. and Huguley, C.M.: Randomized Study of Cyclophosphamide Alone vs. 'Cyclophosphamide, Adriamycin and D", . in Small Cell Lung Carcinoma. Proceedings AACR-ASCO 16:246, 1975. 5. Durant, J.R., Bartolucci, A.A., Gams, R.A., Dorfman, R.F. and Velez-Garcia, E.: A decade of Southeastern Cancer Study Group Studies with Nitrosoureas in Hodgkin's Disease. Cancer Treatment Repts. 60:781-787, 1976. (SEG 340) 6. Smalley, R.V., Murphy, S., Huguley, C.M. and Bartolucci, A.A.: Combination vs. Sequential Five-Drug Chemotherapy in Metastatic Carcinoma of the Breast. Cancer Research (in press). (SEG 339) V. Omura, G.A., Durant, J.R., Conrad, M.E., Carpenter, J.T., and Gams, R.A.: Toxicity and Preliminary Efficacy of 5-Azacytidine and Beta-Deoxythioguanosine in Refractory Adult Acute Leukemia. Proceedings Am. Soc. of Hematology, December, 1975, Abstract #118. (UAB #116, SEG 268) B. Durant, J.R., Gams, R.A., Velez-Garcia, E. and Dorfman, R.G.: Advantage of 12 Monthly Cycles of BVCPP for Complete Remission in Advanced Hodgkin's Disease. Proceedings AACR-ASCO May, 1976, Abstract C-87. (SEG 340) 9. S lley, R.V.: Five Clinical Patterns of Recurrence of Carcinoma of the Breast. Proceedings AACR-ASCO 17:172, 1976. (SEG 253) 10. Vogler, W.R. and Bartolucci, A.A.: The Effect of BCG on Remission Duration and Survival in Acute Myeloblastic Leukemia. Proceedings AACR-ASCO 17:109, 1976. (SEG 341) 11. Keller, J.W., Knospe, W.H., and Huguley, C.M.: Biweekly Chlorambucil and Prednisone in Chronic Lymphocytic Leukemia Consolidating Remissions with Same or Cycle-Active Therapy. Proceedings AACR-ASCO 16:245, 1976. (SEG 355) URL 07243 12. Omura, G.A.: A Randomized Comparision of SynchronizingRecruiting Therapy (Arabinosyl Cytosine, Vincristine, Metho trexate plus Leucovorin Rescue-AVML) vs. Myelotoxic Therapy (Thioguanine, Arabinosyl Cytosine, and Daunorubicin-TAD) in Acute Myelogenous Leukemia. Pi eedings AACR-ASCO 17:29, 1976. Abstract |113. (SEG 354) 13. Presant, C.A., Smalley, R.V. and Vogler, W.R.: Cyclophosphamide plus Dimethyl Triazeno Imidazole Carboxamide with or without Corynebacterium Parvum in Metastatic Malignant Melanoma. Proceedings AACR-ASCO 17:241, 1976. (SEG 361) 14. Smalley, R.V.: Prognostic Factors Indicating Likelihood of Response to Combination Chemotherapy in Patients with Metastatic Breast Carcinoma. Proceedings AACR-ASCO 17:285, 1976. (SEG 253 and SEG 339) 15. Perez, C.A., Krauss, S., Bartolucci, A.A., Durant, J.R., Lwenbraun, S., Salter, M.M., Storaasli, J., Kellermeyer, R.W. and Comas, F.: Thoracic and Elective Brain Irradiation with Concomitant or Delayed Multiagent Chemotherapy in the Treatment of Localized Small Cell Carcinoma of the Lung. A randomized prospective study by the Southeastern Cancer Study Group. Cancer 47:2407-2413, 1981. (SEG 76 LUN 307) URL 07244