Document DvZmx8NpdaqQGN8wz6Bv6Ygj5

INDUSTRIES To: Mr. L. F. Sargert INTER-OFFICE CORRESPONDENCE Date: February 28, 1974 From: Zeb G, Bell, Jr. Location.- 19 Ease Subject: SPI Toxicity Testing February 26, 1974 I have looked at the SPI proposal for testing resins in their letter dated February 21, 1974. The proposed 90-day feeding study will tell very little or nothing about the potential carcinogenic properties of VCM when administered orally. As stated on the second page of the cover letter to Mr. Wedel, any protocol should be discussed with FDA and have their endorsement. We should not second guess FDA's approval of the protocol. My first impression would be to await participating until they (SPI) have more information to present. Attachment cc: J. A. Clapperton A. G. DeMarco L. B. Grant, M.D. W. B. Graybill W. R. Harris W. P. Lawrence/R. E. Sourwine A. T. Raetzsch/D. Duncan V. A. Sarni/R. E. Widing/G. M. Zapp T. Taylor/H. B. Lovejoy, M.D. F. J. Trunzo H. C. Twiehaus/H. W. Rahn form 503 A REV 6.1.7Q if l \ SL 091907 THE SOCIETY OF THE PLASTICS INDUSTRY. INC. 2.90 PARK AVENUE * NEW YORK. NEW YORK 10017 212/687 2675 February 21, 1974 Mr. D. P. Wedel PPG Industries, Inc. One Gateway Center Pittsburgh, Pa. 15222 Dear Mr. Wedel: THE FDA's PRIOR SANCTION OF PVC IS IN JEOPARDY UNLESS YOU ACT AT ONCE'. This is not a "scare" headline to attract your attention. The FDA has raised a question about the carcinogenic effects of VCM used in PVC packaging, and it wants S.P.I. to provide it with toxicological data. The attached report which was prepared by a special task force chaired by Art Sheldon of M T spells out in detail what is needed. Should the FDA withdraw the prior sanction, the fallout of this action upon PVC products other than packaging could be substantial. The expanded vinyl used as seating in automobiles and furniture could come under attack. PVC pipe would probably be attacked by its metal pipe competitors. Realizing that the present situation affects the entire PVC industry, Ken Midjel, Chairman of the Ad Hoc PVC Liquor Bottle Committee, in consultation with S.P.I., has proposed that a separate ad hoc conmittee be established to monitor the proposed testing. It is only logical that PVC resin producers staff this conmittee. The bottle producers are primarily interested in the 90 day feeding test. Of course, some fabricators have a large interest in PVC packaging and they may wish to airport the two year study. -- We cannot emphasize the need to move ahead with the feeding studies just as soon as possible. In order to awid delay by trying to determine upon what basis we should assess four different classes of interest, we propose that you indicate on the attached form your degree of interest in the PVC industry. S.P.I. will then equitably assess you on the basis of your reply. We estimate your maxiimm share would be $8,000 to $10,000 for the two year study, lhe cost will be spread over a two year period. SL 091908 2 Dr. C. M. Naher, Ethyl Corporation, has bean asked by S.P.I., and he has agreed to chair this new Ad Hoc committee. The Ad Hoc PVC Liquor Bottle Comaittae, with the formation of this committee, will stay in existence, but will discontinue further work in this area. Should the new ad hoc committee need their assistance, the Ad Hoc PVC Liquor Bottle Committee will convene. Assuning that this will not be needed, we anticipate that the Ad Hoc PVC Liquor Bottle Committee will not have to meet until the new ad hoc oonmittee has completed the 90 day feeding studies and it is ready to report its findings. Please complete the form and return it no later than March 1, 1974. The FDA is waiting for our response. Should you have any questions, please contact me. If we don't hear from you by March 1, you'll hear from us. cordially. Thomas J. McGrath Director of Packaging Services TJMcQ'pb enc. l * T nt if t Td il 1 P" O W i / | (TV t-ml lV C* 6C ro Til4 T a C r A*- e~rt tifir tc t iA THAT C H Caii-Tm |TC)ft "to HaU t" T H t" iv Wt'tf A *14 TUf4(.,,Vl( TtrZT f ^-rtf > S-V tr 7~o f***S A? m J>>f* y c/*. /> r. THt/Jt a* A/t/>*-**/.-Ss r A AfTf/r A *J r. 0~>AL4T S) cr & /Tj ^ H. 7^ a' Jaa-, ** *- Ca* vr sf*'Ar fie Uy fi O-* ,'v , /t /Jo r',-f,(7 ' a l -s a r ^. v LLt/Ci_ rril L/C L OP L/C ft \ J As fAis/cy*_ ^o-U,^ d> ^ u /li /$ C/e u /rS* AUf r SL 091909 THIS LETTER WAS SENT TO THE FOLLOWING INDIVIDUALS: Mr. Herbert J. Kandel American Chemical Corporation P. 0. Box 9247 2112 E. 223rd Street Long Bead), California 90810 Mr. R. J. Ventres Borden Chemical Coupany 50 West Broad Street Columbus, Ohio 43215 Mr. Harry E. Connors, Jr. Diamond Shamrock Chemical Co. Diamond Shamrock Bldg. 1100 Superior Avenue Cleveland, Ohio 44114 Dr. C. M. Neher Ethyl Corporation Plastics Division 451 Florida Baton Rouge, La. 70801 Mr. T. C. Walker Firestone Plastics Coopany P. 0. Box 699 Pottstoim, Pa. 19464 Mr. Jean F. Malone B. F. Goodrich Chemical Co. 6100 Oak Tree Blvd. Cleveland, Ohio 44131 Mr. W. F. Christopher Hooker Chemical Corporation 1515 Sumner Street Stamford, Connecticut 06905 Mr. Jack Jaglom The Pantesote Co. of Hew York 26 Jefferson Street Passaic, Hew Jersey 07055 Mr. H. w. Nolte Stauffer Chemical Company Plastics Division Westport, Ct. 06880 Mr. G. E. Diach Tenneoo Chemicals, Inc. Intermediates Division P. O. Box 2 Turner Place Piscataway, Hew Jersey 08854 Mr. V. L. Larson Union Carbide Corporation Chemicals fi Plastics 270 Park Avenue New York, New York 10017 Mr. S. Salem General Tire & Rubber Co. Chemical/Plastics Division P. 0. Box 951 Akron, Ohio 44329 ` Mr. R. E. Workman Goodyear Tire & Rubber Coupany 1144 s. Market Street Akron, Ohio 44316 Mr. Curtis W. Collyer 01in Corporation Designed Products Division 120 Long Ridge Road Stamford, Ct. 06904 Mr. Robert L. Knapp Uniroyal Chemical.Division Uhiroyal, Inc. Spencer Street Naugatuck, Ct. 06770 Dr. A. R. Adams Air Products t Chemicals, Inc. Five Executive Mall Swedesford Road Wayne, Pa. 19087 SL 091910 Mr. John E. Ertel Rob entech 1407 Texas street Port Worth, Texas 76101 Mr. J. F. Gabbett Conoco Chemicals Company Continental Oil Company Park 80 Plaza E Saddle Brook, New Jersey 07662 Mr. Karl A. Hochachwender American Hoechst Corporation Route 202 - 206 N Somerville, New Jersey 08876 Mr. Alex Kaufman W. R. Grace & Company Hatoo Chemical Division P. O. Box 27 Fords, New Jersey 08863 Mr. W. J. Vogel Reynolds Metals Company Packaging Division 6601 W. Broad Street Richmond, Va. 23261 Mr. Joseph L. Downey The Dow Chemical Oonpany 2040 Dow Center Midland, Michigan 48640 Mr. K. L. Mai Shell Chemical Company Div. of Shell Oil Co. Polymers Division P. 0. Box 2463 Houston, Texas 77001 Mr. D. P. Wedel PPG Industries, Inc. One Gateway Center Pittsburgh, Pa. 15222 Page 2 Mr. Jack L. Shafer Marbon Division Borg-Warner Corporation P. 0. Box 68 Washington, W. Va. 26181 Mr. Martin F. Bretl Rohm & Haas Conpany Independence Mall W. Philadelphia, Pa. 19105 Mr. J. N. Koral Cincinnati Milacron Chemicals, Inc. West Street Reading, Ohio 45215 Mr. M. Kohno Kaneka America Corporation 919 Third Avenue New York, New York 10022 Mr. A1 Keller M & T Chemicals Rahway, New Jersey 07065 Mr. Frank M. Harris Aim Packaging, Inc. Erie Industrial Park Port Clinton, Ohio 43452 Mr. William J. Smith American Can Company American Lane Greenwich, Connecticut 06830 Mr. William E. Risch Anchor Hocking Corporation 189 Container Place Springdale, Ohio 45246 Mr. Kenneth J. Auer Celluplastics, Inc. 55 North street Fitchburg, Mass. 01420 SL 091911 Mr. Kenneth G. Michel Continental Can Cospany, Inc. Plastics Container Division 633 Third Avenue New York, New York 10017 Mr. L. L. Otterson Dura-Containers , Inc. 3424 West 48th place Chicago, Illinois 60632 Mr. Robert P. Kittredge Fabri-Kal Corporation 3303 E. Cork Street Kalamazoo, Michigan 49001 Mr. D. E. Paxson Kerr Glass Manufacturing Oorp. Packaging Products Division P. O. Box 4000 Lancaster, Pennsylvania 17604 Mr. Clement J. Comay Marquis Products Co., Inc. 931 E. Convent Street P. O. Box 52452 Lafayette, La. 70501 Mr. C. Malcolm Cooper Owens-Illinois, Inc. Plastic Products Division P. O. Box 1035 Toledo, Ohio 43601 Mr. J. P. Bennett Trio Products, Inc. 250 Warden Avenue Elyria, Ohio 44038