Document DvQX09eG2EJMROdMV1rM3gz8a

Clinical i oxicology of Commercial Products ACUTE POISONING MARION N. GLEASON, M.Sc. Rnsorrh AunKKtlr in nmrmnctdoKr, Sehtmil of Medicine and /Jmm/rv, The (Mi* iwifv uf Hihhenler, liinhritlrr, Nrn< York. ROBERT E, GOSSELIN. M.D., Ph.D. /riw ifritu iot'rn / uf IlmrmticiiliiKy nnd I'lwirmwi, Hnrinumlh Mniirtil Nr/iim/, /Aiminmt. Mrw IliimieJurr, HAROLD C. HODGE, Ph.D., D.Sc. /Vft/`aMir mini (Imrmnn nf Hmrmnrithigy and Tmiminffy, Sehnni of Medicine ntui IhtUtnlry, Thr Untvemle >4 Huchrmttr, Kitcltcstrr, Nno York, ROGER P. SMITH. Ph.D. Anneiate Pmftmor of Ttoxiniag, Dartmouth Medici Sehooi, Hanover, firm Namp*hirr. . Third Edition 45t%THE WILLIAMS & WILKINS CO. BALTIMORE . 1969 MCNS 076123 I Mist AID A GENERAL EMERGENCY TREATMENT i t IN8II0UNIS INDIA . TNIIAMETICS INDEX SUPPORTIVE TREATMENT . TRADE NAME INDEX GENERAL SOEMUUflONJ . MANUFACTURERS' INDEX C t A S S I FIC A Tl O N OF POISONS . CIA...............CATION OT < C.3ICJ.Z z~~ c r '""`mi I co. i t T5^ClfrRAT.NG CHART i Irir^ Irish w Class ftratafcl* IfTMAl (nmr.) 70 If ima (140 1*.) 6 tv|>f toxic 5 extremely toxic 4 very toxic 3 moderofely toxic 2 slightly toxic 1 pracficofly non-toxic lest thon 5 5-50 50-500 500-5 gm./kg. 5-15 gm./kg. above 15 gm./kg. a taste (less than 7 drops) between 7 drops ond 1 leaipoonM between 1 teaspoonful and one ounce between 1 ounce and I pint (or 1 lb ) between 1 pint ond 1 quart more thon 1 quart | FIRST A t 0 & OENIRAl EMERGENCY TREATMENf } < INGREDIENTS INDEX THERAPEUTICS INDEX i I SUHOI1IV! TREATMENT . TRADE NAME INDEX j GENERAL FORMULATIONS M A N II F A C Til R IIS ' INDEX I' i CLASSIFICATION OF POISONS CLASSIFICATION OF I : ' 1 R ` ' AID t GENERAL EMERGENCY TREATMENT I : INGREDIENTS INDEX THERAPEUTICS INDEX MOMS 076124 Preface "In ihm rk. hcn it kKaU be found that much in omitted, In it not be fnri'ntten that much likmW i* performed." D*. Samuf.i. Johnson (on completion cri hi* Uitltonery, 17.V.J The purpose of thin book in to Assist the physician in dealing quickly and elfeetivcly with acuta chemical poisonings, arising through misuse of commer cial products, 'Hit book provides (a) a list of trade name products together wuh their ingredients, (b) addresses and telephone numbers of companies for use when descriptions of products are not available, (cl sample formulas of many types of products with an estimate of the toxicity of each formula, (d) loxicologicnl information including an appraisal of toxicity of individual ingredient*. (e) recommendations for treatment and supportive care. We suggest that the physician take time to understand the organization of the material in the seven sections of the book before an emergency arises. An illustrative chan, Hou to Use This Manual, senes as a frontispiece. A study of this guide, with hypothetical cases in mind, is recommended. The contents of each section arc briefly described below. Section 1. First Aid and General Emergency Treatment As a synopsis of the physician's role in chemical poisonings from the first phone call to (he final disposition, this section outlines in sequence the general emergency procedures and precautions required in all cases of acute poisoning. Included are references (o relevant material in other sections. Section II. Ingredients Index This section is art alphabetical compilation of chemical substances (ingredirntsl commonly found in commercial products used by the consumer in and around (he home and farm. The acute toxicity of each ingredient has been es timated ("toxicity rating"). Included for almost every ingredient is a brief de scription of toxic effects and/or cross references to more detailed information in Sections 111 and IV. Section III. Therapeutics Index Section MI summarizes clinical and experimental data on seventy-six compounds (or classes of compounds) which are named "reference congeners" in Section 11 because each typifies a group of related substances. This section streesee toxic signs and symptoms and recommended programs of therapy. I I ; | , ' , 1 1 ' ' . ; , ; ! i ` *CHs 0761*5 VI PRKPACK Section IV. Supportive Treatment In this section techniques or supportive trcntmcnl ore discussed, with par* ticular emphasis on these problems frequently encountered in clinical toxicol* ogy. Section V. Trade Name Index Here are listed alphabetically over 17,000 trade names of products which might be invested accidentally or suicidally. For almost all items the category of use is indicated, e.g., rodcnticide, silver polish, hair dye. In most cases the ingredients are stated, with asterisks marking those components expected to be responsible for harmful effects. With each product the manufacturer's name is given. Section VI. General Formulations This section presents formulas for the diverse types of products listed in the Trade Name Index. These formulas are believed to be "basic," "typical," or "representative" and give some guidance to physicians when the trade name of an ingested substance is not known or when information about its ingredients cannot be obtained easily. A method of estimating a toxicity rating for each product is described in the introduction to this section. ' Section VII. Manufacturers' Index The names and addresses of all manufacturers of products appearing in the Trade Name Index are listed for the convenience of physicians who wish to phone or write for further information. The products listed in this book represent a wide sampling of the many thou* sands of items available on the market and used in homes, on farms, in small businesses, in institutions and industries--wherever toxic materials might be accessible to the public. Many of these products are relatively harmless, but are included because an attending physician needs assurance that an ingested substance is innocuous, if it is, aa well as information concerning the ingredi ents of a product that is potentially poisonous. Where to limit the list of trade name descriptions has been a problem. Our initial objective--to describe only products used in homes and on farms--, which automatically excluded materials marketed solely for industrial use, has been modified somewhat. Many of these "industrial" products can now be purchased by do-it-yourself workers, hobbyists, and owners of small businesses, and so, in the absence of industrial health safeguards, become accessible to small children. On the other hand, the wide use of commercial products in institutional and industrial environments has greatly expanded the need of physicians for toxicological information about these products. Many commercial commodities were deliberately excluded, e.g., structural materials and objects which are hazardous only because of possible physical injury, e.g., broken gloss. Most poisonous plants and animal venoms have been omitted. Foods, food products, and dietary supplements are not listed unless the contents of Vitamin A, Vitamin O, or iron are high. 'li. m: r,;, tii.-, Ihf: ' It. fat. scht.iiscr:-. ha-. Trv fiu In . w: ' m. r tin.. old and inter. :r. Built-.:: 1960 it pCa.public and Tt* of Pci.(orrrjul. tion o: rapid . The . book v made : hoaniU goal n:; the ca produc: no: ir.. enta in estin..it in the ; the rre solution informa HONS 076126 PltWACR Vil lltc increasing number of poisonings l>y drugs, both proprietary arui proscript ion drugs, m|H'llcd us to increase the number of such items included in this edition. Pharmaceutical products account for an estimated one-third <*f the trade name products listed in Section V. In preparing this material it was recognized that changes in formulas arc frequent, that new products arc marketed daily and old ones discontinued. To achieve some decree of accuracy in describing the merchandise presented in this index, contributing manufacturers were given ihc opportunity to edit dcscriptions of their products as they appeared in the IDGd edition. Many manufacturers were given this ojiportunity again in 1967. A similar procedure is planned to keep this index up to dale. The present volume represents the culmination of studies and work ihm have continued without interruption since the first edition was published. The authors recognize the limitations of a reference volume appearing once in five years, which deals with a subject that changes with quicksilver rapidity. In an attempt to meet this problem the stafT prepares monthly a periodical which has the same format as the parent volume, Clinical Toxicology of Commenial Products, to which it refers for toxicological information. The con tinuous flow of correspondence between editorial offices of CTCP and contributing manufacturers provides important material for the Bulletin, deletions of old, and additions of new products, corrections of errors, changes of formulas and changed names and addresses of manufacturers. Additions to Sections II and 111 also appear in the Bulletin. This project was initially supported by an interim grant from the New York State Department of Public Health, and the Bulletin was distributed only to New York State Poison Control Centers. Since 1960 financial support from the United States Public Health Service has made it possible to distribute the Bulletin regularly and without charge to state public health offices and poison control centers throughout the United States and Territories, including all centers recognised by the National Clearinghouse of Poison Control Centers. At most of these centers physicians may obtain information appearing in all Bulletins that have been issued since the publicotion of the last edition of CTCP. Annual cumulative indices make possible rapid searches for information. 'Hie milhors have often been told that the task is an imjmsHible one. If (he honk were ns nlhinelusivc im its title purports, i.c.. if an ntlcm|>t.hnd been made to dcHcribc nil commercial products withtoxic |XMcnlialiiicK, we would bcailily iigrre with imr critics. The coverage is iidiniMcdlv incomplete. The goat ha:* been to li:*l (he (tardy |tcreniimts and the eorreot mutuals mid to moil tin* oliMilcseenl ami evanescent thiNiMMids. For instance, hundreds of cosmetic priMludii come on and go oil' the market nnnunHy. Although most of these are not included by name, the bonk by no means neglects them: thus the ingredi- cuts in sample or prototype formulations ore listed in Section VI, together with extimales of the toxicilics of the products. Bccdmko there are many similarities In the formulas of such products as perfumes and cold wave lotions, whoever the manufacturer, the General Formulations Section teems to offer the best solution to the problem of saving space while providing physicians with needed information. : 1 \ j [ \ i ; , , ! ; ! < 1 ; : \ ; j , I ; j I t I { j , ! j j | I \ i | . MONS 076127 VIII PMKPACK In presenting information nbmu product composition and ingredient toxicity, the same format has l>een used here as in previous editions. Material in oil sect ions has licen extensively revised and in many places completely rewritten. Toxicity data nrc more extensive nnd inrc intensive than in earlier editions. As already noted, all product information has iiccn brought up to date: final changes were introduced during the eorly months of HHi8. 'Die pages of each section are numbered in sequence separately from all other sections; the appropriate section number and title appearing at the top of each page sene to designate the section. This convention was adopted to simplify the printing process nnd so to reduce its cost. Citations to sources of original toxic* ily information arc more numerous than in earlier editions. deferences to the medical nnd toxicological literature are located throughout Sections II nnd III, nnd occasionally in Sections IV and VI. In addition general references useful in clinical toxicology are baled in Section I (pp. 14 lo 17). To edith >crvi for t.\ Sir. with com.-, thi. . the !< I*:r. has cat m: Div;. viror. sion . the I at Ia of M and rt c r . He;;: for T:. mar.. moi. as-:-: exet: \\k> - on p. - vm.. MOWS 076128 Acknowledgments To the many pcrwsu who assisted in the preparation of the first and second edition* c' CTCP, the nutlmrs acknowledge again ihcir indebtedness. Muny served gmerously and ellectivcly in furnishing ond helping to analyze mnteri.il for the third edition. For both old and new services we Are grateful. Since the inception of this project. our effort* have brought us into contact with many informed and helpful people. Some of their names and manifold contribution* nrc acknowledged in the Introductions to the various sections of this volume. In some rases te.g., Sections 11 and HI) this acknowledgment takes the fornt of an identification as the source of a `'personal communication." It is a pleasure to make a public statement of gratitude to the many individuals who contributed and collaborated in this work. Financial support of the CTCP project, both at Rochester and at Dartmouth, has been provided by the Public Health Service, Department of Health. KduCAtioo, and Welfare, through the following research grants: No. |Mi-?()]f>, Division of Crnrmi Medical Sciences, NilI: No. KK 00181, Division of Knvinnimnt.*l Knginecring titul F*wl Protection, BSS; and No. AC 00211, Divi sion of Accident Prevention, HSS. The present grant, K0I-DS-00007, is from the Divi>ion of (direct Health Services, Bureau of Health Services. Activities at Dartmouth Medical School have also been aided by a grant from the Bureau of Maternal and Child Health of the New Hampshire Department of Health and Welfare. Furthermore. Dr. Roger Smith is the recipient of a USFHS Ca reer Development Award (1-K3-C.M 31.789) from the National Institutes of Health. We arc most appreciative of this generous support; without it our ef forts would have been severely curtailed. The preparation of this edition represents a collaboration between 2300 manufacturers and a team working at the University of Rochester and at Dart mouth Medical School. The continuing help of Dr. John D. Gabourei and bis assistants at the University of Oregon has been a major contribution. With few exceptions our many letters to manufacturers have been answered with un failing courtcsy and remarkable patience. As a rule the information we solicited was' sent us, and valuable suggestions were often volunteered, such as reference sources and useful names and addresses. Especially valuable were toxicity data on products or their ingredients. Deeply appreciated were the words of com- ACKNQWIJtDGMKNTS mcndntioo which appeared in hundreds of letters. Many of these arrived with whnt seemed to he telepathic insight into the need of a staff for encouragement while harassed by the many perplexities of this project. To the publisher and the printer of this complicated volume we give a special note of commendation for the vast amount of work undertaken and well done. Su|M*rvi*ion has been ably provided by Mr. Dick Hoover. Vice-President and Editor-in-Chief of the Williams & Wilkins Company, who was in charge of this edition. Wc acknowledge the wise decision of Mrs. Vivian D. Khoad*. of the Kcdactory. who placed in the competent hands of Mrs. Mary Hutchinson the diliicult task of preparing the material for the printer. To her and to Mr. Richard P. Griffin. Production Editor, is due much of the credit for the final appearance of this volume. HONS 076130 Contents SECTION I (PINK) First Aid and General Emergency Treatment SECTION II (BLUE) Ingredients. Index ........................................................ SECTION III (WHITE) Therapeutics Index ........ SECTION IV (CREEN) Supportive Treatment SECTION V (YELLOW) Trade Name Index........ SECTION VI (WHITE) General Formulations SECTION VII (PINK) Manupacturers' Names and Addresses Ill-1-230 VI-l--132 VII-1-23 I MCNS 076131 SECTION II Ingredients Index INTRODUCTION AND EXPLANATION Section II is an alphabetical index of almost 3000 entries. In it an attempt has been made to list every compound known to be a promi nent ingredient in widely used consumer products (with a few excep tions noted below). With the aid of appropriate cross-referencing, toxic ity information can be located for each compound or class of compounds listed here. Included in almost every instance is a saroiquantitative or categorical estimate of the acute toxicity in terms of a numerical toxicity rating (sea below). When possible there is a brief description of toxic symptoms and treatment and/or cram-references to more de tailed information in Sections ill and IV. A diligent but not exhaustive survey has been made to locate relevant toxicity data tor each of the ingredients in this compilation. Sources of information are indicated by literature citations; completed references are listed at the end of Sec tion II. What Substances Are Included An effort has been made to list here every compound known to be a prominent ingredient in popular consumer products (other than foods and many medicines). In such a naively ambitious project, errors of commission and especially of omission are inevitable. In any case neither the inherent toxicity nor the toxic hazard has dictated the selection of entries for this index. Innocuous materials have been included when ever it appears that medical practitioners may be unfamilar with the compound and with its lack of significant tcnicity. In the basic index (left-hand column) each compound is listed by all of its common names* official names and at least some of its chemical synonyms. A few common trade rn^nes arc also included (notably widely used products with only one active ingredient), but if only the trade name or trademarked name is known. Section V should be consulted first. In many cases drugs and medicinal agents are included (with particular emphasis on nonprescription items used in clinical and veterinary medicine). The drug list is incomplete, however, partly because we believe that considerable information on drug toxicity is readily available to most practicing physicians. Indigenous plants with toxic principles have also been omitted (except for poisonous mush rooms). although the active toxic ingredient inav be listed if it is com monly used in commenced formulations te./:., oil of cedar leaf from arbor vitae). Not included in this compilation are chcmiculs which are used only by industry* in manufacturing processes and which are not found in the final consumer product. 1 MQNS 076132 2 SBCTIOK IK INGSF.D1XNTS INDEX How to Consult Tkii Index To locate toxicity information about any ingredients, first find its nun* in the left-hand column (column 1) of this alphabetical com pilation. The position of each entry is determined solely by the letter sequence of its name, irrespective of the way in which these letters may be divided or interrupted by word spacing*, hyphens, parentheses, numeral, etc. Not counted in the letter sequence of chemical names am numerals and such abbreviated prefixes as: o-. m-, p-. 0-, n-, S-, ar>, fi, arc.-, ferf.-, irym.-, eis-, tram-, txo-, ertdoetc. (Note that in Industry and commerce these prefixes are commonly omitted in spite of the ambiguities that this practice sometimes produces.) On the other hand in the cam of compounds where these prefixes are com monly written out le.g., ortho, para. iso. beta, di, bis, tris. tetra, hexa. etc.), this index should be consulted under the first letter of the pre fix. Common abbreviations have been compiled and included <e.gM 2,4-D, DDT) and indexed under the first letter (eg., DI. When an in gredient is designated in commerce by a code numeral without a single latter (e g.. 1080), consult this index under "Compound----- In look ing for a particular sodium, ammonium, potassium or calcium salt, etc., it is sometimes more expeditious to search under the name of the anion. . Entries end Their Synonyms (Column l) Entries in this index are of two kinds. Primary entries are capitalized; secondary ones are printed in lower case. Beside each secondary entry the only information provided is a cross-reference to an appropriate primary entry (listed in column 3). In most cases the latter b a syn onym of the former, but a genuine synonym was not selected in every instance. Primary and secondary entries are related in the following ways: each primary entiv is (1) a genuine synonym, or (2) a substance so closely related that no important differences can be distinguished by the clinical toxicologist, or (3) ths active principle or constituent, or (4) a class name, or 15) the name of a specific example. In many cases these distinctions are self-evident, but to avoid ambiguities explanatory footnotes are included. Names serving as primary entries represent arbitrary choices among the many available synonyms. Wherever practical, short and simple names were selected for the convenience of physicians who may be unfamiliar with complex chemical nomen clature, but our primaiy concern was to offer names that are both dis tinctive and wall established. Below each primary entry in column I. common chemical or commer cial synonym* (eg., a trade name) are record#' By .hb device we hope to prevent confusion between two entries with similar names. Where the entiy in column 1 is a mixture, the principal active ingre dient, rather than a true synonym, is given. Where the primary entry* is a class name, one or more specific examples may be listed. In practice these distinctions are probably obvious. HCNS 076133 Ita, Hist find iu Mwtmxr.l comMy by th letter Mi these letters 6, parentheses, chemical names t O*. n-. A/-, . (Note that in amitttd in spite duces.) On the tribes art com* trie, tetra, hex*. Ntar of the pre- bduded (e.g., Dl. When an in* without a single I ----In look er calcium salt, the name of the I hit capitalised; secondary entry > an appropriate tetter is a lynelected in every In the following 191 a substance Itetiiiguished by eonatituent, or In many cases ties explanatory Mtiea represent irms. Wherever the convenience lemicai nomen* at art both dis* Seal or commerthia dev ice we similar names. I active ingre* ) primary' entry led. In practice BCTWN U. INCREMENTS INDEX 3 Toxicity Rating (Column 2) The numerical toxicity rating of column 2 it largely explained in Table 11-1. To use toxicity ratings effectively, their many implicitiona and limitations must be appreciated, as noted below. 1) The rating is based on mortality, not morbidity, i.e., it is really a tetteriity rating. In general a clinically significant illness may be ex pected after doses of about one*tenth the probable lethal dose (as the latter is reflected in the numerical toxicity rating). 2) Unless otherwise noted, each rating is based on the acute toxicity of a single dose when taken by mouth or gavage. Other dose regimens and other routes of administration are not represented by the rating. 3) The toxicity rating reflects an estimate of the probable or mean lethal dote, not the minimal fatal dose. Perhaps because of personal idiosyncrasy or hypersensitivity or predisposing disease, minimal lethal doses recorded in the clinical literature are usually considerably lower than those implied by the current ratings. 41 With only a few compounds are clinical data adequate to establish a toxicity rating. Most of the values here are based on laboratory deter* minations of mean lethal doses (ld\#) in small laboratory mammals (rat, mouse, guinea pig, rabbit; sometimes cat. dog and monkey). Im plicit in the use of such data is the conventional assumption that the mean lethal dose in man lies in the same class as does the UH* for the test animals. Whenever available, however, clinical data and even clinical impressions have been given precedence. 5) Toxicity ratings followed by interrogation points are based on obviously inadequate data: some represent no more than "guesstimates" (In the language of a popular news periodical). 6) For most corrosive agents, such as mineral acids, alkalies, bleaches, etc., no toxicity rating is suggested. In these cases death is usually the result of severe local tissue injury, with secondary complications such as toxemia, shock, perforation, infection, hemorrhage and obstruction. The intensity of the local lesion and of its sequelae is often determined by the concentration of the corrosive substance, whereas the volume and "dose" are secondary considerations. For such agents no single toxicity rating is an appropriate measure of lethality, unless the concentration is also specified. No simple parameter describes this relation in a way which is thought to be clinically useful. 7) In Table IM common units of measure are used to describe lethal doaes for an adult of average size (body weight of 150 lb. or 70 kg.). For patients who are heavier or lighter, probable lethal doses are proportionately larger or smaller, and they can be readily estimated from values of mg./kg. recorded in the table. While we appreciate that infants and children are not simply small adults, reliable clinical data are so scarce that we are forced to assume that lethal doses are pro* portions! to body weight irrespective of age. Recognized exceptions are noted in Section* II and III. ft) Although all are based on Table IM, toxicity ratinp in this sec* HONS 076134 4 SftCTON U. INCREMENTS INDEX 1WiSrl<NrClMi TABLE 114* rntokh UmtAL Dw Own*) lA(. rKt|.ew(uiV) Soper toxie 1 Extremely texts 4 Very taxis t Moderately toxie t Slightly toxie 1 Practically oontoxic Lamthaal HO StMOO 800-4 gm./kg. ft-Ugm./kg. Above IS gmJ k A tacts (less than 7 drops) Between 7 drops and 1 toaspoonful Between 1 Up. end 1 ounce Between 1 ox. and 1 pint (or 1 lb.) Between 1 pt. and 1 quart More thaa 1 quart * Modified from H. C. Rod| and J. H, Sterner (American Industrial Hygiene Association Quarterly, lOt 4,1940), whose original table was designed for Induatrial Mt toMaaar compound*. tran have a distinctly different meaning from those in Section VI. In Section VI each rating is an estimate of the toxicity of a complete comserics! product, as it is marketed and as it is described in Section VI. Here in the Ingredients Index, each rating is a measure of the inherent toxicity of a single ingredient. In establishing the toxicity ratinp listed here, each dose has been calculated in terms of a single substance (usually technical grade) and is generally based on experv menu in which only an innocuous solvent or vehicle was used (such as water, corn oil, etc.), omitting all solvents, additives, and other ingredients found in the usual commercial formulations. Because many of the ingredients listed here are unavailable to the consumer in pure or undiluted form, the toxicity ratinp in Section VI are more realistic io terms of clinical exposure but are inevitably less accurate than thoaa In this section. Miscellaneous Comments (Column 3) In the case of secondary entries the only comment in column 3 is a reference to the appropriate primary entry, as explained above. In a project of this size and scope extensive cross-referencing is the only practical way to economize on space. Inevitably some of the internal cross-referencing may appear to serve no purpose except to frustrate the busy reader, notably when he is directed to one of the several pri mary entires which provides almost no information except a further reference to Section III. For various technical reasons, however, it was judged important to preserve the format of Section II wittr-rt excep tions and so to avoid inconsistencies and possible ambiguities. In the case of primary entries most comments in column 3 concern toxicity, toxic signs and symptoms, and treatment, although notes about composition, sources and common uses may also be included. Treatment may not be mentioned for one of two reasons: (a) because Section 111 is thought to provide adequate information (which can be MCNS 076135 pAnliUl Hyitone Hi hr Industrial i Section VI. tf a oompiste M in Section Maura of the | the toxicity of single id on exp#ri nsed (such u > and othtr lOOOUN many rar in pure act realistic molt than hmm 3 it a shove. In ii the only he internal frustrate tevtral pri- a farther mr, it was Mt excep- ll concern kgh notes p can be BCTION Q. INGRCOfKKT* LNDCX 5 located by consulting the appropriate "reference congener" Hated in column 3); or lb> becauM the only recommended treatment is tymp- eomatic and supportive. Whenever practical, toxicological distinction* between the entry and ha "reference congener" are emphasized. Whenever relevant the cuta neous and percutaneous toxicities are indicated because these are not measured by tor necessarily related to! the toxicity rating* of column 1 "Central nervous depression" often mentioned in column 3 is equiva lent to the toxicologists' "narcosis" and must not be confused with the psychiatric syndrome of emotional depression. In its severest form central nervous depression culminates in respiratory arrest from gen eral reflex paralysis. In its milder forms many stages can be distin guished: headache, inattention, vertigo, excitement, confusion, drowsi ness, stupor and coma, often with a terminal convulsion which is prob ably due to asphyxia. See Section IV for a discussion of supportive treatment in this syndrome. ' References to published sources of toxicity data have been cited in most cases, especially when no "reference congener" is designated. For the completed literature citations, consult pp. H-lSo-173. The Meaning of a Reference Congener (Column S) An attempt has been made to group toxicologicaily related com pounds. so that each group can be typified by one of its members, designated here as a "reference congener." Ideally all substances hav ing the same reference congener are chemically related and produce similar toxic effects by mechanisms which are biochemically akin, so that one program of treatment is appropriate to all. This ideal had to be modified in order to restrict the number of reference congeners, which were selected on largely arbitrary grounds. In practice, a com pound may differ considerably from its designated congener, both in quantitative and qualitative terms. In spite of its deficiencies, the de vice of a reference congener is a reasonable attempt to coordinate, correlate, and record succinctly formidable masses of toxicity data. For information about or relevant to any substance listed in this index, its reference congener should be noted in column 3. This con stitutes a reference to Section III, where the toxicology of each con gener is discussed in some detail. Within reasonable limits each dis cussion in Section III is applicable to all substances having the same reference congener; we believe that this is especially true of recom mended treatment. Bibliography of Source Material A bibliography of published and unpublished reports about human and animal poisoning* can be found on pp. II-155-173. These references represent some but not all of the source material upon which the MONS 076136 6 KCtlON B. INOREDtKNTS INDEX toxicity information in Section Q is based. Each of those reports is cited at least once under the appropriate entry or entries in this index. Comprehensive literature citations appear at the end of each congener discussion hr Section III; therefore, these citations are not duplicated in this index. HONS 07613 7  ------------------ u tutMMi ml limm/m tlMKad I'riMM levnny ItM (MmM BI.CHON II. INCiBI OH.NTS INDI.X CfWMMXIllWWf ciiioinvwT Mr vhlMviltHl 4, T- Pmlnbly rkkirtlMW I* IwkI itTwrlM lylnic m Um hnmlrrllnn liriwmo Vnielty <lnn 9 ami 4. (Mr*1 tlrrn CIIIOIIIMNK, (Myryuri Ct*iMr 1* kpclkw III. | lirf. i Amttnmm (1.. IMS. (`Mlt'MIOX/l'XMDK 0 A trniM|Millr.rr nm-.-lnl.xl tn rM-mtrnl nlrtwiom xny hiih'i .ima, M >-m i> HVIHHM'llliMIlMK b-m-rltaxl hk n widlil nlntarltr, tie-*H iiinin-li- '(ttnl, im i-Mr-llv., .M.xinvwtniwH, nml , I.MtrhHH <t wnitk nnlr.*-*.l-, Im IiIrH it-imw ll pix*M-*-x nlnxtn, .`.itrMn, *t~l llnrrlo . WHMii.WiI Mi'lk.HiiliMlliif.f* ilim-x (tt|> Ih -IN inr. kill*) Mhla rllifIm nrr mil -.MtiM.-u, lri> > In* n .imI hIiiru * in m-en with ifc.nrn afi In Itm mi:, .billy. No rxtrn|ryrntilikil lr:ni >l|M.r.|i-ri. owl nx l>< Mini ore inn. In mixt imb|ix-ta, rhtr.Nt iImm ttt> M imr. > -.in-ivl :<>mI In r.-rc limlMiM-rM alt-iv mill nm*. nr II*mI clinnw* *-r- n..t.*l. nmi r.-*--v.-ry w - rmiKol In nil rnm-n. Hof.: lbi*iir*i. Itn.il; KfimmilbM an PMwor Anikkvri'iaiii mhH lh.-r IVtvHoiU'rnx-nUc l!rw. WMt; y.MmMn rl *1.. 1W.I, t'hl>>r<*Mne Mr*> riH4HMirTANi>l. In lh|* Intln. (<> tor rvm.-DK'IIIJHtDKTHVI. KTIIKII In thin HwIrK. (>* . ChWvhwtrttl 1`h1.irinal.nl l-m..-nr rHInitm.I.-l l|4e'Myl toe A I.UMINHM CHI/>MIDr tn |M imlrs. **' Nm> Ht:xA(:m4iiiiim:N/t:NV.<r>>nr iiiciiirmoMCNTiv.Nr. ft- r n-> m oi im*-*. ( Mm t'HWHIINATKI) IMI'MI'NYI. hi IMa (mlr*. *'* . t*lil..r...i.-l Rm imAIMICNk! Im UiIm Imb-fc. C'lllDItlNATIII 3 MmIm c-wtxlllmxil >tf vimr nywtlnHIc maen. fever* llvrr (ill* InllllrMl'x. or it*-rr*ixl Ihim DtPlllhVI. Urrn rrtxtriiol In IwlHMirInl rK|tMHrrn 1' *ii|i>ir. I.lvrr ilnmurn In rule ' ip>*uh| b mi'b-rlnl v*liMr<livl-nvl wllh All lu rkloi'litr rnntrnl (prntnrhhiritiM|>lii'Myl). mi llvi r 'himni-r in riilJtll*- in t CkkirMitli'il lit|*rnjrl mnlrrUi wllb i: ,, chhirlni* ntnit'iM (irli hlnr<MH|ilH'nyl). T*trllv ml In: In IhiikxI an an xml e. a.. An<t'lni iIkn lw min. MUn i-ffi'i'ln In mim arn rnri'. llrf.: Trtnarlnl.. 1 ' CtllaHUKATKD IIYIXIOCAII IfcINB Thr rMortnntrrl tijnlrnrnHam acKrnla am l'nl tyi>i(lxl li)r rarlnm IrlmrMnrlilr. nkcr-M Um eklwlMlMl hvHrurnrUm Inaevllct'lrn are Ini eaainpltflml ly DOT. Thr lyt.lral lone <1- lerU irr autilaely illlirmL Tho ehlorlnautl nnivomn nm liver nn*i kniirr a>i<l Mmlral nrrvmm dntrennatu. vhrrcaa DDT ami eonRcnnra am murwinaniH. (M a alanr DOT ami CAIUIIN TKTtlACIII/HimK. K< (rrrnro C<MRmrra Hi Kr>-un lit. I OIUHIINATID UMK * Ctil.rt'lnaU'il miHtlhnlence TWn mlalurr nf rnIrhim rMnrlrlr ami ralrhtm hri>rltW>rMr hna hIviwI ucli*'< rMorinr, ImiMil n|Hi l|a k)'|an'Mnrllr ivnaml. An wllb t>ll>r ntrivmlvo ar*-nln. |Im* lM ll* milK >( a mIiiIIw ibyaxMln mn H r-.m-.-.lmlbm. (Ann nlmn MYIVtCIIUHim'., in l. ri.M h | l...r...H-r hKrlMIII.1 lli>(.: IWfk nl l'.. I'M.. dm HAim'AX la thin Irnkm. ^ Ckktrlmh|)l iwrndki CkkirltMinl |Mbih Mm PAIIArtTN. CIIIOIIINATCn. la IMa Imtoa. 8na JAVKLI.R WATKil la IMa (Mlm. <M CMnrittitH ix'HtifMin* km (VII la iMn Imloa. km VOIIIMIMNi: la IMa Imk a. *** 1 rMoriimieri Mlmu ! Chlorinated urrwM , CHLORINE OAt AND WATER CII10IIMEXANOME Trancnptl OVUIkivpl i ra CHI/mWATEO HYIKUlCAnnONS la Uila Inrtea. tea BTD0DANK (a IMa Met. l:', ' Water iKaaatvaa abaat twiea lie leiume el chtorlae saa. (ermine a miamre n( hybreehlnrie aari (ypaktomw arMa. Ceriealra berawaa ef aoUJItyand ttMtelnc poicnilil. Correet aeUkaala by alull Umrapy. 0 chlorine eaa hna bean InKtletf, tnluhtlnn N the (olionine pray (or aeroaol) hna bee* rawwmanrict: an anwcowa aeiutinn e( amlium hj-ponuUlui (J") and aodhna carbenala (0.1' 1. A near tlmwnlne ta a (reah wnlrr pool eontAinine only il.l a.a.m. ehleriaa raaaliad In (nlmlmllnc mtlmonary edema after aaoIrMion. (lor r> ?iraMry axpaaarea aaa .'ClTnOCEN OXIDFR: far Meealion aca inPOCIILOKITE. Rrlcrmo Can* penera In Section IQ.) RM.i OleauilaM, IMt; MeCord. 1036, Modal). 1W; Nsttanal Safety CeueeU. 1BU. A palcal metele tmlaxaM with aa oral taalelty leaa than meprobamale. toaaaalanlne. or laelhurarhamnl Blocha palynynaplle rrflra arc* bat net rrlalcd In ehomieal atnicairt m meprabamala. In ehronlc labertlory aladlea Ihc only adveree ctfcct mind mi ataala. al a Mill doaaea level. In clinical trials enly a. 3^ of 4063 imllcnu hn *loo rllrcu, mainly aaoaea. drawalnoaa, iMsalncaa. amaknena and IImMai. Ovcrtlaanrc up m IQ era. hna noi aaanad death. Orn larae nmeuni prmluce mly ml Ml Mo rlfcrln (alleni cnnfualnn, vrriiRO, aavnaa. thmwnNionn). Itceemmemlad clinical done in ailella 190 mg. 1.1. >1. lief.: llotli, 1MII: tVtnlhrrm l.ilim'lnrtc. ISSA. Nca MnM)CtMi>Nr>AO:TIC ACID in Uila Imlra. ,l) fee TIDCIIIOItOACr.IXlNinm.K In thin Imlra. I.Chlni-vallyl illrU^II dllMnrarfciueate Bra VEOADiat In this Induu <01 | p-CItLOIIOANlUNE M'l Bald I0 be aura Male ihnn aniline. Can be abaarbed Ihmach Inlaei btln. (Baa alaot AHIUKE. Rafaraaaa Canaaar M Baetlaa IB. Ref.i me oettlngen. 1041. ; ir * Ciil/n"*'- '""tmT'1 '* 1 'v* lluor-... f l (< U..-. i'.Xiv.,- * trU/ii-cm/-i 1 : .-.r- . Ilf'X'.-X...', CltU-iiOJ.i / i'.I'.u -Tru CiU/.i! ' TV r m/.H-M ai I.A 1 1. .v-1i,;...-.,.i iiirl*wn..u- 4-Clilur .................. C>l 1/>:; Vnnwu . dni: ic.: . 2*cn:iru-4-. carfcw. I-. vim 1 I-Clll. ! Clil..r,..-: , CM..I- - 2-CU.r-.-4.. |}UCteMy HMMMhMMM ^IWwtlMWIWtl M,A ClM Nm IUAMm*A ImM**#! HONS 076138 nr pWhMwl|,| M"i M--MI --MImh-taoUral-ti moMioc. Ml--fiM fltcnoN a. wcuEDnomniMx 1 1 1 1 ~TwUr SthTaTilMiflM H Cm-- /'oMI r\TMC AMiivn MM'I P-- -- tob-M'ft <*! cvnac cslomdc. UlC aw CWINI to Ml MB, MBCOrrtMQUINOLBUTiMMp a--ncaLOMpniBji* ia *ie mm--. m 0--ally 44 to 49% ifMto to--di ipWlBti Ua-- M mi --l--. 0--al--i iM> IB, hlfcwB! Caaaaaar to M4MB BM Bbt.i HiMMCb, to*., IMB. 4 MM to tottoa Midi to-f*. P--to Wbaa to--itod to la itoUat to tto --freta to --htoto toiT --to (%.., mumb). (m *ii corrca ---------- .--------- ,, toittoi BL) Md.i 1. Marta. Utot. u -aw----------. eyp a--ato f^rt,.-brdr--y- ................. ........ . ................. a-- COWH> BALTa iCWMft to Mi lad--. MaCOFFM QlUTOUllOLATCto -- Mu. W C--T bMHI mam ones M iimimMi DqmUMMi, to--wr. m yattow TWtoM 0--MO C--Midi a-- oorrui ml icupwo ta --a lad--.1,1 *1) A --illy ---- --rtottnial t-peMi. Pres--ly --aai--li m----to dto--Ire to Mtoto a----at It --a toa eorrmt tototoy mm to >tn to-- l. (to* to--t coma W atoll-- c--a--t to -- a.) m.i ca--au a pt-My --d c--wy, ma. A--CALCIUM CYAKAMIDB to tola 1--ax. (M CVIIUTBS 'nito I hi to--HIM M fytot amr Mm bardetltoe ton--a kMII| cIimh S --d 4. Maw to nre --area---- a* vyaaaia to ay--ld to --ambit, hm i--im pr----i drew--wm. dn ' tomtoll --ItoMN a-- de--b to rata. TW#a artoa aattoaa it* --t yitoMIl to ey--Ida. Stof.i Btreb --d tow, iMd. CTWPW MBlto Ore f tto U*ubt plan towwa. T to eSertre, to----t -- to pr~wpi (-- to--> CTAIUNE, Bit--t C------r to toeto-- Ul.) M Mtobli-- tMCTAM>-OaCIIUIK>niSirTLACaTUC ACID to tola f--i--Oi aOM_________ -______ ------ Clllll--llll___________________ 11 ACTIftjOMTMtX to Ml MM--.***____________ erAMHNeatonomeimACinruc Cf-- M dtobtore 4 A pto-- crewtb i--toiU-- --i-- wto-- tobMry act-- -- pd-- re--Mu to-- to --atoll tutor--Id*, dp--ratoty an re--lly ab--it-- ihreu-- todn b--a-- rafetui are --to M totor-- a M-br. to-- appltoiu-- to M4 , awre U-- -- arto bmm U--to to la rala, Itod.i M. Uartto, 1--T. Cl 1 HIM Cy--aa--ri--iMdtoi CTANOO--UMC COMPOUNDB Mtotto Mr--trep CtCUTHKN ' A-KyOa--m--1 -*-BM>)d~ treyeto--atoa-lre-- Mb CALCIUM CYAMDC to tola tod--. (l1 -- MSTKYUIBMCUUC DdCYANOAMIDt to tola tod--. (I> Ma-- to totrttoa (ar ajaaldaat are --bim----d to tba bady to ytoM UcMy wato ayatoda (CM- -- HCM). (Maal--1 CYAMDC, Itotare-- Ca--ar to toaitoa B.| 1 a----aaaaaaMy re--nMtog ft a--prretbrtoa to ttorteKy. (S-- aiaat mCTMAUM. Balarwai Caa--air to S--ttoa m.> Bat.C--poaiar at.. I4M, C--itot-- >pto--Mari-- CYCUMAIWTAL HKpto--ird irtd MU-- C1CLOCOOMABOL fKb--m Kwlitoidtoil-b. 'tytouMtorto --Id 1.4-C--a--lire . to-- 4 a-- AdrnaatAMlMCa to --a todM. W A aadaUre a-- byp--in df-- -- -- townaadtoia daraUoa -- actto*. 0--cray--to ttabady; datoaIftod by liver --i Utowya. Adtot bypaaui ----i 140 to SN |. tore)). Paul M-- la --pal-- II be aura to-- 14 PM. (B-- ale* BAANTUHATKS, Itofereaea Ca--aaar fa MaM-- BL) Aaaaaaatl--t eflatly rain-- to bla--d--ay----rta. <Ma t--i WAJi/Aail*, Sale--a Cab--air to a--M--IM Ma BCtotlTYL*a>AMlNOaCNZOATC U lbla 1--. <U B-- KBPTABAAUTAL la tola tod--. i f a-- QUUNNfa to tola lad--. fn'MNIKXAN* tore--.!--aaaaa areas--yto-- 1 Viper a--a waab --nbeaU ad brtrf darni-- bat --are --to-- to-- br--a. Hlpb*---- eear--irUaaa bare pi--aa-- eaavulatoaa to rabblta, ToalB aval Mm-- to r--bita i-- ta ptrew dtorrto'1, alreufatoty eaHapre, a-- Boaib, wuba-- pia---- re--val whim da> araaatoa ar a--atoaato. A----iy meal-- gemralto-- vaaatoar M--uai --lb da----ran** Into-- to brato a-- rtarera. Ka adreia -- Me-- ferraattaa bara b--a --wrtoad. Mildly trrttott-- to bwi-- akto. tto ayMamfa patamtnpi bare ban re--rw* to aa-- Hal, i Aaatrla--ItotralriM b--ftoia, ll&M} Trrea -- al., 144ba IMA. wAh--nm &A p--v **mt l--MUMi >mmCmnhmi wUp--Baa* **AieiiM 4--* I t I 1 I 1 I MGNS 076139 J * l*IWwd IlMWi aHMwdilliipiBM Twit RtM (|M lasdi tmmi mcnmu. mcnmEjm trtotx CvMMatelMiMitapM CrtvSkMM CYCLOMEXANOL CVCUMEXAMOMS CYCLOHEXANONE KMBOOC OnMnurM H)4itWMnrl|` 1, B-tomtoylfcaffcUavta M NAPHTHENIC Acme la tola totoK. w % toto to ton htoalaltoa *t wwr. iww and iwbvw natra ywBM. M.I Tmidri., IBM*. 1M9B. iliriW Inliaai M.I TmMtil., iMt, 1943B. **> Uaad a caUlyto for too Iu4hU| oC caruia ffoaiftaa raatoa. Ulpat tea wbbmI ib team wwRw atttoa -- mm --4 <# mantor--. Aa m $ aalaOBO m dtoMyl aBttealtot tt Baa ptfaatirai LDW Ib tofeo >11 y./kt. Km baaa rtpartod bb kltorfBB raaaanatoto for toto aaaalUaailaa la bb. M.i CBCC lcwW| Ufoi XAB-NWC. DtHiMMii MbUbb, IIH, bb BENZENE to IM* todan. <*1 -- KPCOfoANMTALIOPnililBfolBfoMB. W WO"CyctobcNyH~at*rMartiturtt nm CVCMMUOMEDE CYCLOMEXTLAMtNC m--ii|<mhi>-- AaatoaorrlalianaBa MwliNiTMlihwiwI t*CYCL0HEXTL*4. - MNTIIOPNKNOL 1,4-DWtn-t' yeMwq-1 pteaool >M CYCIOMRHTAL h *U Mb. <* Aa MBfotoUe fteactotto of k*gk tmoetty. t>-|a Mar ibo bontorlta* bowman wuatty bImbbi mt 1 to awktri 4 prabtoly to Oafa (riui| *((te ratal, to all thvao aoolBa. tom )B|WBi toeInto aacoaatva mUvbUbb m4 dlarrMa. Btoadatalned laaaa say anaa Ina nmlir laatoaa of iha calaa (BWlay) or atamacb ami amAll totaaitoaB (Bacal* Ra* Mi B| aBBto itbbbmbi CBMral aorvaua aynaia totoitaiaBM Mik titntri and to to af ftrtofB BMatodBBl trrtmttao. to all *!** imH. daatb la >rw>M by aorta. AtraplM, tou- tfmftoma to pM-avd rau. Death la dttovad toM aat pra*m>a, ualrsa lyAiawiUBi ar adnnai aanfcal attract* an alaa anpiavrd. Balt Oral* aai Ofehoai. IBM. * Baoara cauatto acilaaa aa Mr a*a muaawi atabrMt. Baitalc affaat* to maa tarlada aanaa ai vbmiUbb. aMtoty, raailaaMaaa, aai dcvwatnaaa. foiaai-qrpa cwmlateBi aaaar to rafcMta. Trato wpaaatoUcaUr. Ba|.: Watraua aai Stall. IBM. Bra N1IJU-4M n tola toda*. w tola portal). (too alaat DOOTHOPHENOL. Rateranaa Caaroaar to laaaaB HI-1 flaf.t Toetotocal Davatopaeat latoaritoHta. Taeteaatop Braaete, Cato--anahla Dtaaaaa Caalac. IBM. CyttafcMytntotoaaa Cyetml aadiam C1CLONITE Cytourlmt>tyt--ttWITMtot ROC I.M- triMM-^UTtUlM tWflK Cyatonal Cprtapan CYCLOPEKTEXYL- I-AILTL BARBITURIC ACID Cfttopdl (UMw ClWfN OlMimUII m- r-Cotopeatony!-*fcytoaar-B-fMthjrl'SrynlaprtM--- 1-ona aa METKYLCYCLOMCXAflE to Ma taiM. <*> Bta KCXOBARRITAL BOMUM to tola Into*. (S) Uaai aa a toflt opteiiva to Warii War D aai awplayai aecaatoulljr aa a ratoatleMa. b- aapt for *tea, wftete ar awra raaiatant, aeata toitolt> data |rua. caiai Plata tola eatofomi soar too bartorltew baiwaaa elaaaaa 4 aai 4. fortoptama to pnlwwl aauaala raafa foaw toUrMac torn ib atiM byperrvflaaia m aavara aanralaiMB. latotatrial avrtevra MpasMl la BOX km tatoilr rammlaai ar Kara Baaataa u**aaavtaa wito* mbvuIimu. Tha tow pratoBBltary algaa nrtotoi toaiactea, ilatlnaaa, aauaaa mb vomtmn- Wbaa - aalMMMM wbb ragatoaA (few tolnoiaa ib 24 bra.), toiarralttaM KMar. waakMaaaai aaaaaa nmi Ictwtrr waa evaMuall)- canplata. aliSawgh toara ara matoaunuatai nparta of toaika la Ganaay. WBUa aaparaatlp davali of hamatatotoral ailaeta tnclutoac aatototoaglabto romatfoa. at toaat ana patiew tuntul torily altar canwlataaa had aardtoaaaatoar MS*a Itoa toaaa todaaaB to alutto u4 otirsctycsro. t.., npa voiaa. alavaiad tyatolie aad drprcaato dlaawUe blood praaaura. (Sra alaat MrRJTE, Rator- Mt Cannaar Ib Brcitoa IB. 1 lUl.t KmimbiL. IBM. * Mo k-CYCLOPENTtKTI ft-ALLYLRAR1TtTUC ACU) to tola latos. ,5> Bn k-CYCLOPtNTENTI^S-ALLYLBAHClTanC ACID to tola todaa. <3) MT) A aadatlva and hypnotic drag paaaaoatoti a abort to awdarata dnradM al action. Adult kypatto daaat M to IM tof. (aral|. (tea alaat BARBITURATES. RatetaaM Caagawr to laattoa 10.) Boa CTCLETIIIUN to tkto todaa. ^ Crclt - IV -amatbylaaa axtto Cyvlniritnrdijrtonrttialiramint CjMm Baa TETRAUTDROrURAN to Ma lnd. m Baa CTCtOWTE to iMa Into*. W Bw OWNCE IKED to IMa Into*. M> aa QtTXCE WED to Uda litonu (1> CM| ANlM kMMn ^Adat CMfIMM W,A C1MMM tMirateat W-* **r -- nm i*.a I-* < Mil ii lUrv* la 1* U la! I'M in r 1* .......... .. Kill mnr . v.r . . ... . , in a-- > ltt t. <i i i> i ' a a !'* ! . in MOMS n ai 076140 - mcrwjw il iNCRCDitKra imocx 41 a to ddmtyl phthalato It blMHN MaMIty llWM I b all M DNlM, MM an mMiH iflMU (Hr rttWOMBI.) Rai.i MMMtoahU Dtaeaeo ft* (onto, M4 plN* MitM feMotrial aMrttro eueeeiMftatoMneoitoW. fh. in and I--mm, When eon* EgMOObgtoal IncMine Em. MTIHTK, tutor- at artMa. AMI w fl*AlpaaitolMN|bfll ij jr--I *-| r------------r.mel. a-. y ,\nuDt __ ^ ;..<-^Wa>lrn.Mi^- 4 wit _ 1.________________ Dan XTLEXE U tide Index. a* XYLENE In (Me todax. ,J| Mattolri se a (anWti. ton *nlt largo dooeo. Rata da* oieadlty Rpm> aU vttfc dlirrtoa alter 10 u krt mt MM aniontimes anma several day*- Ha dasue pathology haa bMn MkM u letmlly paiaoood rata, and the moehantsm ot Math la aMwetvw. *--* ~it"~~------- - ~i--l rr*'----r yr~-irii imn --name m MM and ayea M Uttla aflact at ih# aaaal apray ooneaatrattons. Bads American Cyomaid Co., IMP.______________________________________________________________________________ A popular hocbtoldo. uuually mntfccaod Ito aatu and taan. (Am 1*m 0.4-0, Rotor- Ben i. i-oiCHLDwo-t.a-Pia (p-CHLORQPHtyrn ethane m au a > MMETHTL 2,3. S.l-l ETnACHLOROTEREPHTHALATE la this U > I.B-MCHLOtO-M-POIETHTLNTPA.YrOIM la tba ti ur "TIT" HJT laa M labor*aery animals place this borbtetto near the MrMr Itoe ban fluted Malarial causae irritation af aw and eonjuartseae. Contaminated inw should n*Mt_ newt op_ toe TMOPROPAIATt HTPWOCHLORIPI M thla IM C HYDROCHLORIDE to thla Max. 1 ------------------------------- a 1-HYOBCTAMPtE to tola todaa. (I) a OtfTIPOH to ihto Index. 1 11,4-P to thia index, * toa PMC to Ada index. * a KEOTRAN to thla Index. a DtCHLORAL UREA to thla b am O-D, Betersnoe Cangeear to laatton II > l.l-WCU)I^I.t-ara<p-CWtOI>OPHt!ITL)gTHAlt to Bda tadax.*1* am i, h-mcHumo-s, i-wmethylhydan-toih m uus mm. **>_________ Am DOT. Retoreaeo Coegeoer la laatton m. lO't O.O-Ptmathyt-O.I, 3 AdUtrettojl 4 An axpartmenlal chlorinated >r(Mc phosphate tosectleida. Oae-tanth aa tanla aa peraihioa and than lying aaar the borderline between toxicity elaaaaa 4 and 0. (8ao alaet PAJIA- THOU, Reference Congener to toetton m.) llel.i atoll Chemical Ca., iNh. lhadle ntohuhada Uraner OCAROL MHmnthylamtoaMini thenar OWAE Id rATHlOttOTCTIIAtVCLOOCCAKOKE Cvmpetmd IIM Kepeao - Ian BELLADONNA LEAF OR ROOT to thla todmu w Ban DKANOL In Ada Index. P> A new type of aervana ayaieia stimulant. a narMtl aonetUaeat at brain and herbage a pre earner at brain acetylcholine. Dutea aa ki*h aa 1200 mg. dally produce no aenaea ante Mete; and a etegte 0400 atf. deae tahen in a iwcidc nifan Nee n* ainm ellecta. Bxpnrlmaatxlly deanal ia Moon to aMagantce the drpreaaant efleet at barbituraiaa. la high dally daaaa II la obit la produce eptlrpue aelturea la mica and rata. The principal aentralwtoeatten to It# oaa ia grand ntai epilepsy. Rat-: HoaUay, ttdO; Marttorty and htahane, IPSPt Marphree at al.. IPSO. Available aa water dlapambla ptmdrr. emulefflable coocemrate or graaul.ir er dual loraoletleoe. Ilea an oral LOo la rabbita oi about S mg./kg.. In raia el M.StO. 0 n|.A|.. and a perevtaneowe LOftO in rabblta of 4SS-I1 mg. /k*. Typical ODr-ltka tremera devateped. and death to the acute phnee wae preceded by eamplcte proatratlee. Bendary atlmulathm iriggurcd or lotenaliied tremora, even aa leng aa 4 weeka altar the exposure. It la peaatble ihit a rvpeatterv el (he wetted la ereateO in lha euttnteue **> H'dranaytdhalana IdCAIJN m, lee DECAUX to IM Index. ,S> h<T| DarmatlUa and onnlunctlval Irritation. hyeUMM MnUcUy la iwt uoll deflnod but no aertoua Indeetrlal poisonings are kaoux. Leas taxto (bar `etrahvdrwpbthaleor to rata. Vapor apoeurea la guinea pipe ceuae caurarte end bhfewy leeaeae. Ntl.i Brnoailng, IOSO. *n Ciewy nMM Manama M, MONS 0761*i [ a.toon mcusioon inodc Ota <... ITU ay aata mMmm, pdwmary tortwato*, mint, Mnittfnai, M atttaaa an gaaaraily tnmatattt and ibar* art m law aadarlafe to MM wttt to (lama ar vary tot iwfM, Frama ma* Wamf* mm mwy toto*---------- i tot pMM Itorto, aurlM, bydraM fltrida td rhtortda, aad adt tolLOl a A yrtrotowai toaotlM oMotaant df a oomplao mtotwa of bytooearbta (Cy ato ^iQrr) ' (to* all bofHto oror (to rmc* JM m dto* F (1U to z**> CJ. SUchUy loaa xvtoBto tot tonoat "MaUttMa* ______toaaM baattog *41 4 Malato toa todroa too mm toitto yoMntlal. (Baa aiaoi kcmmenc, itoMN Omomi m HttoO.} RbLi Gararto. 1M. * mncorvLvm u m. im. pl VtoHa toa RTTROrultASONE 1* tola todt. W rVIUlOUDOKt AHtoXtMurton-l- ldtoaiotoa|taatlHlwaat ItoMM a Uaad to vactaal pnaarotlaaa tor Dtohmam or ocbor tofoaoow. LOgy pnamdly oral) tomtoa. Twde dbaaa to anbnala ptdaaad atdo. wtom, dfamara. aato atialatta. Bof.t Imm Ltooraattoa. IBM. rwnm hibriltotoi Mmitoato-i a told to ba to an at tofrd aa ttte aa tomtldibyda. An imtant to aitat mwirta Caibd trmua daoroailan 1to brain laatona la asU&aJa. lagaatod Ittftoral haa innitoaad llrar cirrhoala to rata, (toa alaai rotUIALDEKYDE. Ratorraea Ca^aaai (a toattoa BLI torf.i MoOtoat. VM8. ____________ ___________________________________ _________ _ * rar.iut ii mi. m. "< too rOBAZOUDONE to Mo todad. W Boo AMYL AbCONOL la Ml todaa. '. o-n to* NSNACHLOBOPHCME to to todt lU OAUICAC1D J,4,l~Tiib)rdrMrr> batata acid M) Apparomly ark low mie rtt aoUcrile arid, rod w boo i* q*Mtia*a of b ta pn. Wltoow fatalltioo and wionmi tw aararo 111 allrvts. Rradlly toorbad t(B too nano totrathial traat. to ammala U radoeaa body tomporaiart and eoaaaa procraoatro woto* ww --d pafbf aoawalalta Bof.i Camara* at ai-. |M: ran Oatttocra. 1MB. OAMBOCE Cambogla 4 A |mb raala aad draatio yortattra. laadtny to arrera praatrattoa aad drath. Tba wsaattoa of 4 tm> haa brand fatal. Bof.t Oool aad Farrar. IBM. GAMMA BENZENE RCXACNLOIUDS OBN Ltodara WtoaeMaraayftabaaaito 4 ao BENZENE KEXACHLOR1DC, Rotor*--* Caaga--r B gaoMaa UL 4 Oartlnal-typa tot AUCYL SODIUM fULTATEB to td todt. P) toa ALKYL SODIUM SULFATE! to ta todt. 4 OAdfENHAUdT. rLUE. BANOE. HOVE, illuminating or MANUrACTCnCO OAB) Catooo mooooM* ICO) la tba yrtnalyal loaie Itradlem tttat or flat gaaaa aar dim coatala oorraalva atidoa of dttragaa and aulfta. Ilia* Ittorad gaa ronalata obiafty of volatile to-drararboM of tow Itlolly (a.(. naathati Mto of hydragant to* earbt Bonoaldo (CO) a--wai oatMlly llaa baraaaa I aad 11*}/r. Nataral twcabulna t CO (ttoaiprodmadby "eraetonf or maa relawd yracaam. (to# alaai CARBON UOKOIODC. Raftrat* Congawr to Bacgaa ffi.) ' 0*o aO Bra FUEL OIL to ta ladn. OASOUNE A oittuwr* atoafly *4 CtoCu aUrdaUc kfAKirtM ab- dlaUllatr, iftn aftar "traciitof" baary BaUtog ftoi ruga la iiamliaiMly 49 la t!t* c. Tavartbyl toad Nanai laNtal mi igwiflranra (a acaia axpoatra by itigaatioa or (nbalMto*. bat Parana *ba in aaratoaa toaat rapaaird and maaatra Art* roman baa drvclc-Brrt LEAD polaotitog (So*. Dll. No MfHtolruia artdIUvoa art boIJrfrd aa ba ilniflewily tanie aa pramm in awntaarctaJ armufaitono. APt>racial*to amamta of aranaOe hvdmarboaa la.a., xytrnoa) ara tomd la rommomal tola, axpaalally arbaa tba patrol*an la trB T#*aa and Callfarato lb aat from aiaun l'.l fialila). A bleb caatam of aromatic MraiitaM and a mmonm high IMKH) ora aim araoeuard witt a high "octait* ratiag" (obanaaar tba laiiar la am 4m to additives, aueb aa triraadivl land or alrohol). Oaaollaa baa ban uaad by Millara to yradure euphoria. (Bra aim: KEROBKNE. Salem** Co**#nr to Bratton ID.) Baf.t Alnaowtb. ltoOi Eaaaoa, IBflli Macbla, lMItWblto, IBS*, toa METHYL AAUCTUTt to Ml todan. u) Bn GA.tMA BENZHXE KEXACHLOWOr lb drta Into*m OELBLMIUlt Ytttaw lamins Drlad rbtionto and POM# of CcUranlutn nrmaorvirvM L. ctoemtoi *rmp*nlr**i* L. $<*) Haa bar* arad m|Mrlra!ly to ibr treatment of nruralfiaa (average doaa M Mg. I Cmuim aa toM % fatani atttatoMat grtramtne, en*|irrvirlne. and grlaemletof, aaeb predating feararra rrratolateM of curare. atropine, and ainchMn* poteeomg*< wralMoaa. wng*, tr*m-ta, piealt. Jaw drag, diplopia. mvdriaata. dyapn*. amiety. navalatea*. Xo >cfilic treatment haa bren Outlined. Hal.: Pool and Farrar. Ito. aa galaemltm In Ado Into*. ^ (,(Al*awnk ***A CtoWy Utond Manta ^AttbaCwatoMai at WaCHnUmr* ^atototMtoid OUKIwtAN>0Pj'l w but* .1 told rltr>" Ala* tow l *Ma. . niMUUuii CUAilN erya*'Ut,i oomed CltoUtwi* ouTt.rww I Uieut* a* KM* -t I -- <1 Olyrrrto Cl.VPt Glytvrwn ' I, Olyeerwl d MOMS 076142 4mMn It aar alt la _ dltopa. btMlMrtlMlllVM ala*. RYPOCHLO- 1911. prtottlv* brad Mki burtut daeara* tat My lull a y,0MM. r--, Ml*. A a*apto #*#d, If irM *T Ail* [--pl--al. (dr* Unmr, iiu. I Mr MmiMl dia- >* *1 Mrtaaorabt* b BIOU IMmiKi ip Cl--I Official*. Utamiavkai ill nw a VKSMMimswou Tpm% E i j ii USk-- I i itRoam Cal At --art M-- urtMl vu lnrMO x*H-- K9RLA* 0,O-D--*tofl<MI, bMImmMmtV ^uaVtiralblMto AM OBCACKLOflOTniUCTClDeeANDrrt la tMa Mm. *** lb--l Ay tb fraettnal rttatUUt-- af fttnliM (belli-- ptlM rant* la 94* MQ* p un to ttt* Cl. CdbCtat* --ally of C*-Cj* hydrocarbon* of dw rHdMM aartoo. ryil.i l* a amll fraeika* at aro-- compound* (xylaara, nr.) aM at umM rtan (ai--mil. b--mlnmpnlUM **ry widely, MpaMiaf aa -- mm, --aitaai ItCIIOSCST. A--iwea Cmomt t* *o--a d.i -- CM 1C CROCKNK to --a todaa. u> Cm ACETOtfe to (M* tot--. p* too THAUBOMIK to tol* to--u m >m CArrtrei on. mb. > *m POLTVTatPYRAOUDOXI la tola Mm. a' A M* MaetlelA* toat l* proataaablp s ehaltMataraa* laklMwr aad m aniai yraduoa to-- taaattoM Uta pat-tot. (laealaat PAAATHDlt, Rriarwi C*f*ar la Mto*a BL) toLt 0-- Cb--1 0*., 1MT. rAAK |.ff,4.-Tri*htor*pbtfMQr|pa*ptoBto -- I-- UOAMAQVK't PltTPS MfhA Ippaabiartto 1M MM* LACTIC A6H Larttaaetd au--atda Uto-- c UMATOODC|t) D%U*-- ClyeoaldM fra* -- --M f DtfttaH* IMM*. MUM ImtaMNK |U**!da A. A, --C UUN tmI 1*1. todroua ffltobf&wntor) huMnw Uc*. UNCCPVR ALKA* L0B>f Drtph--. Crude --da *r* uaualiy piapartd tram -- MfMNM) UMAX'* PASTE A Bbra-- *f rtoo MMI Marti, nnt (1 part). atdpatt*to--a M--I U--M UVDAW* Tlattora af opt-- UUUCACID OMHIiaR Mil UlUTL ALCOHOL t--M>lalMS*l >-D>Ah*mI 1 Unto, tto --toa salt, aad tto attora, hav* atltfmp lavar acuta --led-- --a 1.<-D to laboratory an--. --a atom 9.4-p. RofaroM* CMfamr to Seat--II. | Raf.: K. Mar--. 1M7. H*) Aa maul Mtvttaai * to If aad--a bypochlartto. 4% aato-- aMatto*. 4Ub i.n alto-- Ipillaalda *r aaibanata. Tba Ira coninbot** t* Iba camama artto* h*n aat* -- A Mlattoa af approximately half to* afaav* aorvafib la ala* daaaribM aa *Utomqw,l w--b.'' (See ale*. HYPOCHLORITE aad LTE. IUIimmi Cwtwari to Mlto* (V.) Rad.: 0a*l aad r*mr. X*M. m SHELLAC to toil IndM. ^ m rivcllac la tola todM. w Ttoafftotol U. A P. prartoai u a totoa-- af toette aeld and Uatte anhydride afdnlwt la a* to W bp weight af taatta add. Altbaurh anliaal data ladlcato a --laity raOitv *f 9, attotoal --rtnca baa at--* --t ara* dltotad miuiUmi ton * amwtia wttm to -- b--aa aawhana and at--Mb. (Ira aiaei ACID. Ralaranea CMaanar to JmUm m. t CM KHA-HYDROXYtTHTU-LACTAMTDC to toto K--a. (I> Cm LAXAT08DCIC) la tMa Max. L*m-- C to ia*raftaa aaad aa a eardtatmte --1 Qaa A *r . It baa all -- toartpaatla aad --la act--* af dlfltalta l*af. it* action* ara (cm par--Mat to** too** of did--la but a--ra proton|*d thM thaw at a--phantM*. a 'dltuatto-- d*M of ton***-- C to 9 to 10 nap. orally (af *Meb ab-- CM-ianth la abaarbad): to* daily malatrMne* dao* to tots la I. * f. tba avtua bthal data bp voato ta prob--ly l*|o * umi # dU--ala; la aa vartca --t tot* nnm it * It tap. at torawalda C or --a *at l**a ad -- wcmI laMtoalda alatore (DipUaatdL (Cm --at DICITALB, RafanaM "irrami la Baa--a QL) i Oa-- oMtaateral aaiara af Mgbar fatty aeld* and *toar blpttar aloobola (**tpi|. Mat Cm ntOPlOMAZCfK VTDROCMLORIDK to tMa IndM. 9S May fea abaarbad tomfh toto irkaa to aatottoft. aaoaatolly If tola la knkii. L'aM aloe* aa--*toP b --to body Um (ato-- or natdaa--ot>. Aa a potaoa It raa--btoa inalli, top*at-- praduraa Uncltod or bunlnp a--. Maaea, vomltuip. taltrailo*. bradycardia. bppo--a--. reltopM. tnooaUneM* ol ortoa and fact*, a--*, and daato. Traat aytaptomatically. AtraptM aap balp. Raf.: Marah *ad Ctovaaa, laid. TO Tba to*atlM milcltp at c-- m-- la not *aU aatabllahod. bat probably It la to*. 0 tba m-- la appr*ctob|y aolabl* to caatrle |*--. voiaittad aad pa--itta aup b* aauc--. Raf.i OmI aad Farrar. 19U. a* ALKTL ARYL SODIUM CULPOXATCC to (M* Mm. (4) 4 A Id* Mint-- of opium la alcohol, aqulvaltnt to about I'J taorphlM. Da Ml confute wttb tha Mth matoar C--phora-- Ttocaira of Optun faa* PAREGORIC far tba Uttar), (loo ttoat MORPHINE, to Sect-- ULV Raf.-. OMtandfarru, tU. 1 A a--a coaatlluaal of away vopatabla alto aad iharalar* of taoai o*ratal dtou. n Tbaapbt to bav* a *ry law --icltv. but dafbdttr* atodloa --*1* m* --atod. (Cm ato#; ALCOHOLS. HlOHnU. Rafaraae* Caafaaar to Rati-- t ., a CM-- **wd m*m "lUMC. (aWtNd MGN$ 076143 10*40* MCTtOM n IHCMDICWTtINOU J J 1 1 111 af tap InptOitM (to Ml Camrt *"*) Deled rlpo cood of Hnituti frartoo. tote.. MiTlMtitM to eemmeo mo otoo* to* MMdto Ago* ca heaeemid Mir*. ItoVoog boo on Mutual tod fcoorollp unapprmtomd antelty. to-aptemo oppoor vitoto 1 to hr*, fbUowtot th# ui|*it* to m tom *Mo totoo or to 10 g. to a* grotcd opto*. agn* mod rvttooa oro rtotoioloaoal to mo> pint polmrnc and toetodo nuahlog to tod tola. tachycardia. Masses to aallvatlto and orurtl aoneua oxcttaUoa. Mtooio. boaevwr, ta more common duo mydrlaalo. Mum antral symptoms at oupborto tad haUuauuuooa hxvo prompted ttw irftfiH to Mo apaao bp addicte, alroheliea tndotoara with unstable peraoaaliuee. Moaarptoo to roleetod so o OMlble nuawltt baeoooo mowt aontaiaa ifMpiiM aeMeholloergle iap-tttania tad wmti pOacarptoo owtto be toadMttioi agatxM too central symptom*. The principal to* yodtowto oro too voltdlo alia myrlaucto. aovonol. goromol, ufrol, bonwol oad UaotooL Cato art capaclaUy tootottv* it mjmauato and exhibit central asctlattoo followed bp nai. (to feodlag largo unman (our drgtoaraNoa to too liver woo too*. Appreciate aad oooOout b-irtootral# Uttrxpp to mgBaawd m eeattol central amitodoa. Myriotteto boors earn* atnetoral rooomblanoo lo tarotoala aaucotoata. Bto. i Pam. la**. Mm mooabati so NITMCO to toto tod. U> NUN VOMICA Dried rtpo ooede C toyclii w vomica, amtaudfig 1.1 to 1.4% (rarely Hi atryototoe cod Boot OR Ototol iirri Tf mint OotocUoroceittphese 4 tbs uacairo la a 10% ootouoa to it* sloobol (raryehatao sow. 0. mi, and.too nmlabia toabal doao la a *a. torn vomica ntodauraot (XD itl.loi.li toytOUM <1.8% la BrlUob PbanMoopptoi, and too dried powdered tract to T to T. T% #rhdiaa. (too toot ITKYCKSIXC, Mtmct Caagaaot to toettoa B.1 Bto.'. Oaol oad Pamr. 1M. oo TOXKPNCXE to tola tadsa. OCTACHLOROCYCLOMEXEXOW OBtooo to 40% aotaMm to oetretoom U A bortoelda aad (uaglcldo. Tba ooly baowa toxicity data (from a proltaloary Mroaatog tott) todtoata atoao latMl dooo to about ICC mf. Mg. ia mica, kso b^octM doily lor T w ooaotvodaro. Rto.: MoConaMt, ISM. mtooMiSoM041 too CMLOKAANE to tola todaa. w Oatoehlro-4,T> aMtfwaebrdrtoadaM Ootovbtoro-4, T- too CBLOBDANB 10 tola 0KMR. too CHLORDAKE to toto todaa. u> totomo OCTACMLOttOTETHA- kjnlmtrtM iooaaUcldo probably |yto| m dw tordtt Unt btwtw tvlitlf KYDftOMETKANO- lnt ft wd < (aruto oral LD|* tor axil raw 4. to S. ft mg. .k|.). vary tala by all PNTHALAN mtM; eostperaUe to aodrto. Product* hrPrtrriLblllty, coovulatoea cod fretoleg tl too a.g., Teladrto MWk n utoclt. (Seiatooi IHCLDRIX. Ralareaco Coocnor to tootles OL) Raf.i OotoeIda ltd g, U-OatadiaadltoalB mM OCTADECYLAUINC Otiadaraooto acid toOciadacoaalc acid Oeudrr)) alcvliot Ocudtcii drrlvathaa Oatalma OCTAMKTm L mo- PIRtorilOIU.UIDE ebrodao l^totaaal OCTYL ALCOHOL Mtoil(at) l tlrtkol, RkM Mvcilled ta armal (ur prtotar>1 orlyl or rapr) lie alenbol OCm AllMO Ml M IlCTllAH!* >\A1 L MM- -Oftyl ammimlMm aMUtflltlMM too MCX-tC4 to tola todaa. (1> Baa UNOLEIC ACID to tola ladmt. (1* S flghtMo carbaa atralgld ebato amine easMtlBct aaad at an aa'toorrosfva ayom la live ttoam IBM. Toxicity rauog based on taidloo to mica and rata. Roto bare tolerated dietary lovoto of 1*4 p. p. aa- tor yatra witiiout tlr> of toxicity or patboloatc abaoco. At Itvtta of *404 p.p, m. for from * to 2uS daya. tnorods. nalgM lota tod coma butetogle etoages to maaaotortc lympb nadaa. Kaairolntaatinal moaooa tod th-or. Bald to be a primary MUb oMiUter. Ref.: petohmas at aL. iM; MacDoaald *t al., 1*41. Baa iTEARIC ACID In toto Index. 'l) too OLETC ACID in tola Index. U) co fTEARVL ALCOHOL to thl* Index. (1> t oot titled bora, ate eorraapondinc ALKYL dartvativa lx tola lodmi. toe AUXIIV la till* todox. {U ft A "tyttemlf" biaccurld*. 1. a.. trixaleealad la up to tU parte of plants. Only tllgMIe too# tonic Una pxrathlon. Not i ctoltnaattraoe taMblior ui Htro, but converted to one by Uror. Bralo rholtoonterxe*. hnievor. to not Inhibited to faulty poieooed animila. (tooilaoi PARAnilON'. Refermro Coxrcnar in Vctlra HI. i Raf.: Bldttrvo. 1*93 llaslrtoa. 1M8. tot OCTYL ALCOHOL to tola Index. {iX *<) Mo relevant data oa clinical toxicity wars locatod. (See tlaor ALOOr-LA. 'TTYER, Rvlorcnao Cangeoer to Section Ql.) 1 A to-rbteke avaitablo cvmmrrciallv at ax !* aolutloa. Anlmala racriving latoal oral daooo thm>- bTrC',elt.i'>HHy. r*i>iJ rctrlraii-M. oeei>ii--nal tremor*, tnd umtllittl aaoexl* Iona. AubM'Hei reveal Irrluuon of th* Mtotitnn! nvnit and renal confocttan. (too alto-. ABVl'.XTC. Rotacawoa Cong*--* to totUon BL > !Ui.: Vlnatond Cnomtoal Co.. 1M4. CICMt* Amtto kMMH ^ActMtCantixatM at M,ACMN*a W* >oN Imyi >> t --------------------- i rt4igrl MHNML't --topi oreonaw ^ . dtoarbantmtoo OCTYL CRCa>L Vartans learntf O|cWg-U,mm-a, t*onydlpc>**l Octrl dortvau** Octrl motnyt cm port. -Oetvl pbonaxy et(my r dlmetoyt morvan. Kwyl colliolto ti OttOtWrt_____ ; Ottdtrwearn___ Oil d utowto___, OIL OP BAY felprotooll t | OIL or BOtCAMOl oil or arm* ALMOND I OU at eedxrtoaf OIL Of CEOAB WOOD Cstor oil OU W Horn oil or ciTti'**;' CoMtdo priori! <3%)af *rr.< CitNMlIill .1tolM meto)l toooot, nn OU of OlnV____.. l OU at auctUv1*1* OU of yeraoW*. I OU of harib`r 1 OIL Ol IlIMM* ' 1 on of pMrr.on of WaLte.ir _ | OU ol HONS 0761*4 ! I 1i i1 1 i 1< MWt .'<1 to , im mcntm n tfCMMimiiwocx Tat-- Stw--dap!!--" 7 --t~`f-------- -`l Him B-CMeis-4,*-- (HtflMtilH* cut CM mem MmiM*IMs af Ms tolas-- ri'BM- IM sms ictoal Mas m r-- MM Ms s--. yiMPalo-- * MsMrdsrltns ban-- --telly ctoaaas 1MI. Ac--If -- --as MM. Jim MM Mm Ms rtoatlr rsiatsd tin-ma scrtsMs. Ms ATXASIKK M Ms MM. w Rsf.t DsinsM-MftMsm and Mm. mts Palma> ms Be--, ism. ______Imm ess MnrM MN MIm HrfMM* SMB) asltosl totty Krfi, pn* piniiM t*hlM M Wt4 MlM < to--MS METMOKY SDIAZIXC M (Ms Ms. MS VAPAM Is MIS Is) Ms BMKTILAII M MM to-- W shi MsMAn tf sc-- srsl tostoHris r-- Macs -- tlmpla bsttaaSsM saapa --im -- -- 1. Ss-b-- im eu--s 1 mS Tbsy arc tosrstor* less Isihsi Mss ays--tta sls-- to ltoMrfmic mS scan toss Mss swsl sss-- dswrf--s. Ha--, asms m sprulSh <t --samstl sfCras alkali toy asapai art lam ban-- By Surs--r-- -- fss M ss-- rrtmtoal abartto--. asms sssas hsaolyats. --II. hyps--ta. toto--ratal d-ags,--*<--pr--pt tosab. Hof.j Cm* M Vsr--st. ISMst IMS. Ms SODIUM BUIOXALATB Mis 1s-- ft> Ms nnUM ttSULPATK la Mis ta-- <*> MS ALKYL SODIUM SULPATSB M Mis ta-- MM algtoaat toMs ALOCI MSs ta-- w OtXttt ALKANE WLfONATE MM--akplaiyt Cm 1.1 struck! bytossait-- rfcatas. Ae--oral L0M It mal# alb--r-- fm. >bf. -- -- *. -- toAs--dsnaal LOSS a is--star tbm S ,/k*. Muderata sirtil Irril-- SB ?*. -- 1btM --set ssd toratod rabbit MM. Mailted to savers Irrl--t ta rtoMI 1001VM ta-- Wfrtlirr 1PS4. Mi ALKYL ARYL MJLF0NATC1 to Mto SrtftBMt MM IBM srjrt Mwtfsr aottaass MNMm.1 Ml alkyl sulfats ft --MM-- Hallyi-Itoy--tyl) bsabUsrtos to--MS ALKYL ARYL POLTETHER SCLTATU AMD SULFONATE! to tbU to-- (l>Ms ALKYL OOnat tULFATStto Mi toXXUl ta--Ms MCCOMAKRITAL Is Mto w to toto. wMS TNtAMYLAL SOOCOM MM * Mybwtyl)- iHMabarWtarato H Umm i MBSMI llnlM to Mtota--MsCRYOUTC w to-- WMS PLUOMUCATS SALTS M Mis alltotnmrM* MM ISIBMIMII MM y --Mutiny SM to-- WP-AM1N0REKZ0IC ACID lA Mis to--.MS MANfMODAUCTUe ACID to Mto MImlw aruAlUw MMN iriWMHIW OOttX AMEKATE trass-- arseBCIl'M rare MB--mH>I* MM-- S Ms ARSENICA Li to Ms Is--. W -- ARKMICALK to Mto la--. W kit MsCsstotos M Is-- arts--. --ad is lls btrdrrl-- town --telly sis--s --and S. Otoasto asdl-- arsm-- Is il-- ss --isi It-- 4P* trsssto b*a r to-Mass sc 94% acss-- to mm si Ms usual hydrate. (Sss alast AKSEMC, Rtfsrass* ID-)Oespratr to SssUaa --to --HlgMy trti'slsst araasto. iny an araaato trtos-- smtoal-- s( TS. 1%. (Ms aIasi toAUSEMIC. Rsfsr--s Cssgsasr Ms-- OR.) to was AZIDE SALTS tola Is--. -- to--.lACCMAStM IS Mto MM--MlAUtMt ttostsyto to to--. <3>as EMZYL'P'-CHLOIIOPHENOL tola nrwMmMwl MM-- tiHifM PODIUM PIC. .MONATE MMM to to-- {l}Ms BORAX Mia 4. Af. 1As-- (M*A oral LDjf in rats is sss J (is. M ft-ss as 1ST starry is ws--. A. to to toM -- fis./bf. as a Me aiarr>'. rhs cemiasa Mas as m aunt 1 4 p. torn--. mt mstfslt rwpHal aataratsS -- asluttuas ra-- (r-- . Msi m-- --urnUks cart-- sr l>s. In swra;itto isatrla scM. Slaiasl-- as# asaMWs Sam ar rupture of ihs siomscb may occur (rum eirbon UImim release. Larpr Macs, partiew pat sy-- tmt/mrlarly to tents wIM renal Innult'lctoficy. bars prosused akslssls m as* In pant-- Me extracellular CluM voluma etik nltmi. frank byparttoi--s tatany arc-- aapnsparted by feypofIjrcemta baa sersred in a P-yaarmto ytrlt tor toa ai at Ms asm* topUsaitoa aea OXALATE Mat-- 01. Hal.: OrUfltb. l*S4j Pta--. ISSI. i^Air-m ***cimtMmt-- ^namac--m0 ^'aomnwm ^aIpwmaI--hi y hPsi aMtona mum ib rnoiwn Bwlr .^?"n *J23SS toil--umm> auotcM rsbto I Ii r*MM-- 1 | *baa-- ' nocr.iDOtmOli ACL IS 1 1 SPl MM--')*Md--t A rsab MM--array's i jsteit* MM--<mtM> MM-- * la-- a 'A HONS 07614S acnONIL DCREMKimWDn II* pi ....... i. Aaatoto pataaaad abaap LHlSSSSLJSfib. I* Ipasigra*!*, if. ustsi law ft fM * Ifril C14 tt mNa toNvaIfiembli aiyMt. irrtti Mat. i ttfn.iv on MMKAUTI wfcwa MttoaaalM |VM SfSCLFATS .tfttlaw af m* tjmtofM .Loia tonaa %<.k<aa bronld* Ilia snc btnyl- wbwto*ibMarat* mw lauaf <w talelm haiM a^wa coihooota vAwn abtarau laa rtCOMDC SALTS la tola If. Hi Mtohla aatu at axalle alt hava aaaaatialty tlw aaM watal* ao pm ant (tow aim . omUlt, Mafhrawaa Caaynwr la Sacuaa B.> Mafaiaaai Ciifwaf la SaatMa Ml. 1 to* BORAX n Mia tain. 10 laa BROMATS MLTt la Mi laaaa. W Saa BROUIOt SALTS ta Mia Mr*. <4) laa SCTABAJUUTAL SODIUM M Mia IMl Mo cacootuc agio n mi* na**. to Mo BORAH SALTS la fltoa Mo*. H) Mo LYS la ddo laM*. I4* Ma CHLORATE SALTS M Mia toda*. W ... njl fMto aaM Mim ihtorpbaayl ahaam MMm tliriaia MnitaarlM Stoma oyntfia bin Hlijtb* ha*aayliI.SimoibylbaiSMVMa SMbaa MMSiaaaatala mm DiciiLOWPISOCTAXtmATX ACL it s laMiaa M-MMaia. bin Mvhranaw lin MnaMyl tttbia-' play Mito* amotta aad irnri la farmoUUac < Mtu. Ow mm aval LO*a la faand tMM ma la I.TI : *.4S im./kf., Iia dia i*m HIM drath la a.* t . J bra. N*?araaaia mU aalarteaa vaa prodaet rwan tnflamnatary raactiona la aw pawinmdMl total SytMf at aalanaar apllballii iUiatK tba iiaaiaot atfaet la aUaw* aaadalward. Synp Daatb. PabydraiMa and aaapaatws occur la noat tatanwl oriano, paitwmorty waanpoo mi Into. Onto aajr aaaiw Iran roaptratary (uhm aaaaadary a mm aaaaMala paMy- Baaaaa laiaacaala##*aw ramiunc. itorat, lavar Maiat* to tfeaaaaoaw) aadrw mmy *UHI la to* lam a< itebvpnta and'darloy aaairtia. A dlattoattra aHwaipa nataa af in hltoay ta daaorlfaod: pnraocbyotaioaa dabydridaa pradnaa a ikraitoi Mil la noat naaplaimi* la Ma oanvaluitV tabalaa at lha raaal earn*. Sana mwrHMatal avfei aacgtata Mat filar fcypeniatramta n-odranat nay ha praduMil mtb aaanal aaM (toll U attar latafca la rtttmtad. Good allaieal raapaaaas hava haaa aaiawd Iran partwoatt dUlyal* win *% glaaaaa n *wn la acvoro eiwi T or V* gltwoot ta HN>**a la pa**** Marfa af dlttyau find. Dlaiyala Mwnca ml II to M wl./ks. harahaoa attid. tod aarafal nawdarlaf af W cWatrolyt* atom* to ttyilrtt. IWI. i boy* ott Maaaa. lMi Calria M aL, if Elwaatal.. taasi TbWcry at ai.. itdSi UMifii ISO. Saa t-CMLOHIM-ninfTLPItlMOL la Mia MMa. So* CMROMATC SALTS M Mia ta*a. HI SM CMSSTL1C AGIO la Mia MMa. 01 Ma CYANIDES la iMa Mias. HI a* KEXOMAIIBtTAL SOOtUSI la Mia MS**. `u SM DCMTDMOACCTIC ACID la thla Mia*. 0) Uaai aa a aaaraa af arallahla chtarlaa la ''dry typo" hltMlwa. Koaru* yoodara. MabwaabMgaanyaMlt. and amutlay aonpaaada. Naa aanal UK* la rataaf ISM n./hs., and aa oral attainat irthal dan la rabhlta af IIN ta fSOV a(. >S|. Ta*wity la aptwaMly dor la aanraatra actloa aa mnaab Uniat ratbar Mai w any aymatta aMaan. In tlw praaaaaa af nalanra aa 1* Ma ayaa, oppar rarptraiary tract or aa naln tons It la ondarawiv irrl* latlac. Sa aam UMvtdaala braaaiwaaaam may raaall Iran hroaUMS na mm; lar na Mafiifira~*l af Mia aydrana. aa* MfltOCEM 0X1DEI In Sactwa m ant apprapnm pana at Swdan IV. (Saaaian NYPOCHLOMTE, flofareaea Canyaaar la Mctlao a.) Aal.i SfaaaaaM ChroWal C*.. IM*. Si* CHAO MCltBtCIDK 1 to Ml* toda*. 0) Saa DICHROilATE SALTS (SOLUBLE) U Ml* todax. W Saa THOUM to Mta toda*. H) I hM'jn Maina antoa' trvavlM* I b*Mn Maatyt *aM- *MlaM b-Htara MMiyi haaaaaa ollraaaa * A-n rthyl baayl fair b<l'wn attyt-S. lOtfyropylbarhlwrM Saa .S>PUITBO>a*CBSSOL to Sda toda*. <*> Saa DIOCTYL K)0(UM SULtOSUCCOUTE la Mia toda*. a* ALKYL ARYL SOfXtlM SULTOXATES to Mis Indaa. H> IPS ALKTL SODIUM SULFATES la MU lad**. W Sa* FflOBARMTAL SODIUM to MU toda*. <l> "Ufcaaayai Adttttf Iwh SMum **AadwCndtott* ^AChaitoww *A laactffc lam H ! I HONS 076146 enow it. two*totrm non ttMMiiBndtotomatitonnm ttoatmanattoto mat ----------- ton rotmoinx ta tola todan. Hill. m mxon k N. u. *l H--<* - ItrMKVMR maakn dlanlda toa LAUDANUM to ton atom w 1 Anted (It ta.) Maa totn tntaaaad wttiwm aaptrant torn mr ditto>. ___________Ana tw atonm_Jr_ itft, t Pa'rUrdrd. lilt Hama, M*._____ K wna Mtolatttd to 14 ft MiU. yetaamt toa AMANITA U daa ladn. w IQUCCP 4 Tbe Kw tontetoyet tofaten. rlMMuwif IftlMil make. to Urgaly niftaidto Ita WMMHMM. Ntoednt. >wm u aafcaattfatk m|*. entwine 1. t to 1.1* (by nlftq at MMMlWkl tobnnt u naillHM IW iimMH. m4 MMtlMi M Hft Mftil mmm4 Mmm. Ita m *%vrtf> ipnM (MiM ipm. I gm.) may rituto a H|, <nn*i. witwiiimw>wwHMftm4iii>fin*in cummmim. mr, nMil >eat Uw It .. *f Mm Mly a taw atUltrama in wentMy ilinlil. AllMcfti dntoa ban bate wwrtn lm fee nfnttm i* mat! itmiitmii at taw pant at Mhm, nw Mm km iwtN4 kmc ewaUentn* mwI HpiMf. Anpar- mttf At tottIWl ahMtsMM a* nleottnt. mHK pww m ta *a atoa that ip*- MMM avanmaUy remove* tank witMrtii afcatow. Treat Ukt nleetonn pniaen' ---------- -- ............................................................................................. .. w,t lawt^wi, inti--it toa dumumiscs to tfda fcdax. *J> jnTatoy.K toa nnmom to tola ladn. Sr* toa UXTMCXESIS to ftfta todaa. ^ iMtotolaaaa TOUCHE Mtftirl tonana TMtonl toa BAUAM FCftV to tola todtot. 91 4 immvf la nry atoitlar to ton at yUnt. 1 ay paadnaa a mtto nnwr* ii--u Mat an kdiiliili (it banana data), (toa tint mtM, llafatnra Ciaffair to toaitoa BL) ftaf.i nnOefUagee. me. p-mataadUtotna toat.VMAMCOIOUSNX to ttoa tndn. Wl TOLUEXt-l, 4MftOCYAXATE TO IMM tokmn - ft) Qm t ft* MMMMI toctaiMaata At ptyrnt)iaM Tomad'la-pUct" plaatlea. Tba tUtonato wlnit, tkwh may mir In fMilalmr (* nil and miwllit k tort ant nm. It M*0MUr Inert. Tto t. >-lnw la aln ncwMnil: m mperum mninatoiflaa] igattoa ftnt iff rwiCMN, Tnleliy retmtei t A baaedan data ta rata. ftten togntod. tor aaa an Irritating At iiatrttateattnal Matt. At a nwr TDI la a mmi<) irrihM a toa ayea. ditn. teattratory tut. batoevtol npwrii la awprlatoHy law atneanaettan ton prodntd waraary ayawmat a nnaatoa (aanatneMan et toa abate nft to Anna. Tto aMaturity to aatinaiie attack 1A aavrra brawtoipam to* Wen maturate. X-raya wart noItaonly aay&ave. KnatneyMIU ti naiad. Hmml frtaa wyniw tot re- " tobwa-l. t-ttiwynn yniupcs t'Matoglaatltaa At nto. l3ti Jehaatoae. 1W; waadfray. IMt. Ran. Jtt? ton TOLUENE'S. VDOSOCTAKATI to ttoa ladn 91 LSca anittna. Mat mat to)ary to mar* Utaly. Tba arm aari mi* taaanra pratably ha*a nttartMloittr*. (toaatom A^CUNS, ItataraaaaCaafanr totoeMaaOL) Rat.s na Meal Ibpleaa dUaarynaata toa-TOLtL mftU LMK ACID a.c.. Itonaat TOMOIUX CawnarWar l(-At*1ai>l*4' tWavnbtntylV-4' Hdranyaantoarto TOXAfHEXC CMartontaa Ottotidanem* IVatoctMb TtlMplI toa mvtn to tola Max. toa TOLUESE-t. 4-DOOCYANATE to Uta MAn. w t Aon mett> maaanad to rata atoaaa tola tom** nrar Mia bortarUn at tnlatty aUaaaa S and S. Konwtr, abamteal data iMtriia toi pm acid (pH and Ifttottlnal alkali ftft It) toa)' to'dntoaa ttoa amide to pbrniamta matd (law many) ana a B-toiaMln* <bt(b mnny la m|. toa a-TOLLTDCvT abevt. (Saaattat AMIKC. Wtrm CuftMi to toaMaa m. 1 Rat. i Nacarnk Cbanical. 1M7. A MdMdHda Itoa virliila. wlto detoyad acftaaa an pratorambMt tovai and Meed elattlac. raanktat to acato by bemerftMe. (Baa alarn b.*AAFAlUK, Bateman Congaatr in toatimt A) ftaf.i Mnanry. IMS. 4 aland to Ua natr toa bardarllna briwaaa miefir alaaaaa * and a. (toa aim TOXAFHEXE, Sataranaa Congener to toattoa A) Inn CUU9. VEOCTABLE to tot* tndn*. ^ n CKLOIMCZANONC In thU tndn. W nuaernt* nSimoMOTM- TftDATE n.a. PET _ mPHmDfTtOfT.RFmiO"O---tTt t.i>. r*>u THaalatan arawato. nucnpoioAcrrx TOCKlOHOAcnwiil m* ctis-ai %lyMnn '''atMy aiunaii (nMwm at mACl*nNat IMASmtilitf mamMat HONS Q7bl*l