Document DG0DeajeMOVqGYr09NB8eLbdB

EPA Submissions____________________________________________________________ August 31, 2000_____________________________________________________________ Cover Letter to Charles Auer (EPA) from Bill Weppner (3M) with attachment ______ sheets________________________________________________________________ PFOS______________________________________________________________________ ______ Medical Surveillance and Epidemiologic_________________________________ Interim Report #1, Determination of Serum Half-Lives of Several Fluorochemicals, June 8, 2000 (previously submitted to TSCA 8(e) _____________ docket)________________________________________________________ Data regarding general population OUS blood samples analyzed _____________ by 3M's Environmental Lab in 1999 (no report prepared)_______________ ______ Acute Toxicity________________________________________________________ Report by WARF Institute and accompanying documentation, Primary Skin Irritation and Primary Eye Irritation in Albino Rabbits, Sample _____________ T-1117 (FC-95) November 7, 1974_______________________________ Final Report, Acute Ocular Irritation Test with T-2997CoC in Albino Rabbits, Safety Evaluation Lab and Riker Labs Study No. 0882EB0009, 3M Reference No. T-2997, January 25, 1982 (Bibliography Only - Copy _____________ not submitted to EPA)____________________________________________ ______ Genotoxicity_________________________________________________________ Final Report, revised, InVitro Microbiological Mutagenicity Assays of 3M Company Compound T-2816CoC, SRI Intl Study No. l Sc-8958, 3M _____________ Reference No. T-2816CoC (PFOS DEA salt), March 1980____________ Final Report, InVitro Microbiological Mutagenicity Assays of 3M Company Compound T-2997CoC, SRI Intl Study No. LSC-8958, January _____________ 1981__________________________________________________________ ______ Repeat Dose_________________________________________________________ Draft Pathology Report (Ancillary Study), Electron Microscope Evaluation of Liver in Cynomolgus Monkeys (Recovery Animals), 26 Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; T-6295), Study No. 6329-223, Pathology _____________ Associates Intl. PAI Study No. EM 99.76___________________________ Data on TSH and Lipids in Cynomolgus Monkeys from 26 Week Capsule Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt, Anilytics Inc. May 2, 2000, Includes letter from Andrew Seacat (3M) to Peter Thomford (Covance Labs) March 6, 2000, and letter from Saroj Das _____________ (Anilytics) to Andrew Seacat (3M) regarding methodology______________ Page 1 ______ Pharmacokinetic_____________________________________________________ An Investigation of the Effects of Fluorocarbons on Liver Fatty Acid Binding Protein. Thesis submitted to the University of Minnesota by _____________ Deanna Nabbefeld, April 1998___________________________________ Final Report, 28 Day Percutaneous Absorption Study with FC-98 in Albino Rabbits, Safety Evaluation Lab & Riker Labs, Inc. 3M Reference _____________ No. 4980, Experiment No. 0979AB0630___________________________ Final Report, Single-Dose Intravenous Pharmacokinetic Study of T-6684 in Rabbits, Corning Hazleton, Study No. CHW 6329-199, 3M Reference _____________ No. T-6684, December 31, 1997_________________________________ Final Report, 5-Daily Dose Dermal Absorption/Toxicity Pharmacokinetic Study of T-6684 in Rabbits, Covance Lab, Study No. 6329-200, 3M Reference No. T-6684, December, 31, 1997 [Draft of report submitted to _____________ EPA with letter dated May 18, 2000]______________________________ PFOS Mixtures____________________________________________________________ ______ Acute Toxicity (Bibliography Only)____________________________________ Final Report, Primary Eye Irritation Study in Rabbits, Hazleton Labs, 3M Reference No. T-4016, January 28, 1987 Final Report, Acute Oral Toxicity Study in Rats, Hazleton Labs, 3M _____________ Reference No. T-4016, February 9, 1987__________________________ Final Report, Primary Dermal Irritation Study in Rabbits, Hazleton Labs, _____________ 3M Reference No. T-4016, February 27, 1987______________________ POSF Ongoing Studies Study Outline for Pharmacokinetic Study of POSF in Rats, June 22, 2000 _____________ and Protocol dated December 30, 1998, 3M Reference No. T-7098.1 N-EtFOSE alcohol ______ Acute Toxicity______________________________________________________ Final Report, Acute Oral Toxicity (LD50) Study in Rats, FM-3422, Intl Research and Development Corp, 3M Reference No. T-2253, Study No. _____________ 137-084, June 7, 1978__________________________________________ ______ Pharmacokinetic_____________________________________________________ Biotransformation of 14C-N-Ethyl FOSE in Rats After Administration in Feed for One Week, Riker Labs, January 28, 1983 ______ Teratology - Studies on FM 3422, 3M Reference T-3352________________ Final Report, Pilot Rat Teratology Study, T-3352, Hazleton Labs, Project _____________ No. 154-159, May 11, 1983_____________________________________ Final Report, Rat Teratology Study, T-3352, Hazleton Labs, Project No. _____________ 154-161, March 21, 1984_______________________________________ Protocol, Rat Teratology Study (Segment II), T-3352, Hazleton Labs, _____________ June 2, 1983___________________________________________________ Page 2 N-EtFOSA___________________________________________________________________ ______ Acute Toxicity_________________________________________________________ Final Report, Acute Oral Toxicity Screen with T-3067CoC in Albino Rats, Safety Evaluation Lab, Riker Labs, Experiment No. 0981AR0147, 3M _____________ Reference No. T-3067, May 15, 1987________________________________ ______ Pharmacokinetic________________________________________________________ Final Report, Single-Dose Intravenous Pharmacokinetic Study of T-5904 in Rabbits, Hazleton Wisconsin, 3M Reference No. T-5904, Study No. _____________ HWI 6329-117, October 14, 1994___________________________________ FOSA or PFOSA______________________________________________________________ ______ Ongoing - Pharmacokinetic______________________________________________ Protocol for Study No. T-7132.2; ST-39, Pharmacokinetic Study of Perfluorooctane Sulfonamide in Rats, In-Life End Date November 2, 1999 Lab Report, Analytical Report of Data for PFOSA Pharmacokinetic Study in Rats (Sera and Liver), 3M Environmental Lab, Lab Report No. FACTTOX-145 (W2814), 3M Reference No. T-7132.2, December 6, 1999 PFOSAA_____________________________________________________________________ Acute Toxicity Memo from Roger Perkins to D.R. Ricker - Re: Summary of Acute _____________ Toxicity Study Report for T-4101, March 4, 1988_______________________ Phone Conversation Report from Roger Perkins, Re: Results of Toxicity tests on 4 samples; Samples T-4101 FC-109, T-4102 FC-121, T-4103 _____________ FC754, T-4104 FX-841; Includes invoice from Hazleton Labs____________ Final Report, Acute Oral Toxicity Study in Rats, Hazleton Labs, Study _____________ No. 70905392, 3M Reference No. T-4101, FC-109, January, 21, 1988 Final Report, Acute Dermal Toxicity Study in Rabbits, Hazleton Labs, Study No. 70905393, 3M Reference No. T-4101, FC-109, January 18, _____________ 1988____________________________________________________________ Final Report, Primary Dermal Irritation/Corrosion Study in Rabbits, Hazleton Labs, Study No. 70905394, 3M Reference No. T-4101, FC-109, _____________ January 18, 1988__________________________________________________ Final Report, Primary Eye Irritation/Corrosion Study in Rabbits, Hazleton Labs, Study No. 70905395, 3M Reference No. T-4101, FC-109, _____________ January 18, 1988__________________________________________________ PFOA________________________________________________________________________ ______ Acute Toxicity_________________________________________________________ Final Report, Acute Oral Toxicity Study in Rats, Hazleton Labs, Study _____________ No. HLA 91201739, 3M Reference No. T-4416, April 2, 1990___________ Final Report, Primary Dermal Irritation/Corrosion Study in Rabbits, Hazleton Labs, Study No. HLA 91201740, 3M Reference No. T-4416, _____________ February 14, 1990_________________________________________________ Final Report, Primary Eye Irritation/Corrosion Study in Rabbits, Hazleton Labs, Study No. HLA 91201741, 3M Reference No. T-4416, February 28, 1990 Page 3 ______ Genotoxicity__________________________________________________________ Final Report, Mutagenicity Test on T-6358 Measuring Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells, Corning Hazleton, Study No. 17388-0-437, 3M Reference No. T-6358, FC-143, Lot 332, _____________ April 25, 1996, with Protocol_______________________________________ Final Report, Mutagenicity Test on T-6358 in an In Vivo Mouse Micronucleus Assay, Corning Hazleton, Study No. 17388-0-455, 3M Reference No. T-6358, FC-143, Lot 332, May 14, 1996, with Protocol and _____________ Protocol Amendments_____________________________________________ Environmental_______________________________________________________________ Analytical Report, Fluorochemical Characterization of Surface Water Samples, ______ Columbus, GA (W2336), Centre Analytical Labs, May 24, 2000________________ Analytical Report, Fluorochemical Characterization of Surface Water Samples, ______ Cleveland, TN (W1973), Centre Analytical Labs, May 24, 2000________________ Analytical Report, Fluorochemical Characterization of Surface Water Samples, ______ Decatur, AL (W1979), Centre Analytical Labs, May 24, 2000__________________ Analytical Report, Fluorochemical Characterization of Surface Water Samples, Mobile, AL (W2151), Centre Analytical Labs, May 24, 2000 Analytical Report, Fluorochemical Characterization of Surface Water Samples, ______ Pensacola, FL (W2176), Centre Analytical Labs, May 24, 2000_________________ Analytical Report, Fluorochemical Characterization of Surface Water Samples, ______ Port St. Lucie, FL (W2363), Centre Analytical Labs, May 24, 2000______________ Analytical Report, Fluorochemical Characterization of Water and Sediment Samples, Port St. Lucie, FL Resampling (E00-2003), Centre Analytical Labs, ______ August 24, 2000________________________________________________________ Final Multi-City Study, Field Report for Mobile Alabama and Pensacola Florida Battelle Duxbury Activities, Project No. N100672-01, Battelle, September 29, 1999__________________________________________________________________ Final Multi-City Study, Field Report for Cleveland Tennessee and Decatur Alabama - Battelle Duxbury Activities, Project No. N100672-01, Battelle, July 9,1999____________________________________________________________ Final Multi-City Study, Field Report for Columbus Georgia and Port St. Lucie Florida - Battelle Duxbury Activities, Project No. N100672-01, Battelle, ______ October 26,1999_______________________________________________________ Port St. Lucie Florida Water and Sediment Resample for the Empirical Human Exposure Assessment Multi-City Study, Pace Analytical Services, August 15, 2000__________________________________________________________________ Sulfonated Perfluorochemicals: U.S. Release Estimation - 1997 Part 1: Life Cycle Waste Stream Estimates - Final Report and Executive Summary, Battelle, April 21, 2000__________________________________________________________ Page 4 December 22, 2000 Letter submitted to EPA from Bill Weppner with attachment sheets PFOS Medical Surveillance Letter submitted under TSCA Section 8(e) regarding update of Decatur plant mortality study, December 15, 2000 Repeat Dose Analytical Lab Report from the 26-Week Capsule Toxicity Study with Perfluorooctanesulfonic Acid Potassium Salt (T-6295) in Cynomolgus Monkeys in the Determination of the Presence and Concentration of Perfluorooctanesulfonate (PFOS) in Liver and Serum Samples, Covance In-Life Study No. 6329-223, 3M Medical Department Study No. T _____________ 6295.7, Report No. FACT TOX-030, September 19, 2000_____________ 3M Technical Report Summary and Central Analytical Lab Report No. 6967, provides analytical data for Ninety-Day Subacute Rhesus Monkey Toxicity Study, with FC-95, International Research and Development _____________ Corp. Project No. 137-092, 3M Reference No. T-3351, August 4, 1978 N-EtFOSE Alcohol___________________________________________________________ ______ Genotoxicity__________________________________________________________ Final Report, L5178Y TK +/- Mouse Lymphoma Forward Mutation Assay with a confirmatory Assay with N-EtFOSE T-6316, Covance Labs, Study _____________ No. 20785-0-431 ICH, 3M Reference No. T-6316.12, September 5, 2000 ______ Repeat Dose_________________________________________________________ Letter submitted to EPA under TSCA Section 8(e) regarding results of 104 _____________ week chronic study, December 4, 2000______________________________ 3M Technical Report Summary and Central Analytical Lab Report No. 6995, provides analytical data to accompany Ninety Day Subacute Rhesus Monkey Toxicity Study on FM-3422, International Research and _____________ Development Corp. Study No. 137-088, August 16, 1978_______________ ______ Teratology & Reproductive____________________________________________ Combined Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of N-EtFOSE in Rats, 3M Reference No. T6316.5, Argus Protocol No. 418-009, FACT-TOX-013, June 30, 1999, _____________ Includes Report Amendment 1, October 12, 2000_____________________ Analytical Lab Report, "Determination of the Presence and Concentration of PFOS, M556, PFOSAA, and PFOSA in the Liver and PFOS, M556, PFOSA, and EtFOSE-OH in the Sera of Crl:CDBR VAF/Plus Rats _____________ Exposed to Et-FOSE-OH" October 9, 2000_________________________ Page 5 N-MeFOSE Alcohol_________________________________________________________ ______ Repeat Dose________________________________________________________ Letter submitted to EPA under TSCA Section 8(e) attaching 4-Week Range Finding Dietary Toxicity Study and 13-Week Dietary Study, _____________ July 24, 2000___________________________________________________ 13-Week Dietary Study of N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) in Rats, Covance Lab, Study No. 6329-225, 3M Reference _____________ No. T-6314.1, June 30, 2000_____________________________________ 4-Week Range Finding Dietary Toxicity Study with N-Methyl Perfluorooctanesulfonamido Ethanol in Rats, Covance Lab, Study No. _____________ 6329-224, 3M Reference No. T-6314.2, July 5, 2000________________ PFOA_____________________________________________________________________ ______ Genotoxicity_________________________________________________________ Report to 3M Company, Reverse Mutation Studies with T-1485 in Five Salmonella Strains and One Saccharomyces Strain, Industrial Bio-Test _____________ Labs, IBT No. 8540-09238, August 10, 1976_______________________ Page 6