Document D01rYzYjrQv0zx9K72gDB7ka

ATTACHMENT TO LETTER OF JUNE 28, 2001 3M FLUOROCHEMICAL SUBMISSION BACK TO COMPOUNDS TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE DOCUMENTS Click on Study Title to View Report COMPOUND-SPECIFIC STUDIES N-EtFOSE alcohol N-ethyl perfluorooctane sulfonamidoethanol Repeat Dose 1. Letter from 3M to TSCA 8e docket dated May 24, 2001, TSCA 8e Supplemental Notice (Docket 8e HQ1-288-0373): N-Ethyl Perfluorooctanesulfanamido Ethanol, supplementing prior filing regarding prelimi nary statistical results of the 104-Week Dietary Carcinogenicity Study with Narrow Range (98.1%) NEthyl Perfluorooctanesulfanoamido Ethanol in Rats, 3M Reference No. T-6316.1, Covance Laboratories, 6329-212 and -228. Note: this letter supplements 3M's letter of December 4, 2000 to the TSCA 8(e) docket, which was in cluded on the CD of the December 22, 2000 submission. Teratology/Reproductive 1. To accompany Combined Oral (Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of N-EtFOSE in Rats, 3M Reference No. T-6316.5, Argus Protocol No. 418-009, FACTTOX-013, June 30, 1999 ("two-generation study" previously reported to TSCA 8e docket and also in cluded in the December 22, 2000 submission): Amended Analytical Study 2(N-Ethylperfluorooctane sulfanamido)-ethanol in Two Generation Rat Reproduction, Determination of the Presence and Concentration of PFOS, M556, PFOSAA, and PFOSA in the Liver and PFOS, m556, PFOSAA, PFOSA and EtFOSE-OH in the Sera of Crl:DCBR VAF/Plus Rats Exposed to EtFOSE-OH, 3M Reference No. T6316.5, Analytical Report TOX-013, LRN-U2095, June 11, 2001 Note: This amended version supersedes the October 9, 2000 report and October 12, 2000 amend ment submitted in December 2000. 2. To accompany Argus in-life study, Final Report, Oral (Stomach Tube) Developmental Toxicity Study of NEtFOSE in Rabbits, 3M Reference No. T-6316.8, January 11, 1999, submitted May 18, 2000: Analytical Laboratory Report on the Determination of the Presence and Concentration of Potassium Perfluorooctanesulfonate (PFOS) or another metabolite of 2(N-ethylperluorooctanesulfonamido)ethanol (N-EtFOSE) in Liver and Serum Specimens, 3M Environmental Laboratory Report No. TOX-097, Laboratory Request No. U2452, 3M Ref. No. T-6316.8, February 8, 2001 3. To accompany Argus in-life study entitled Final Report, Oral (Gavage) Developmental Toxicity Study of 2 (N-Ethylperfluorooctanesulfonamido)-ethanol in Rats, 3M Reference No. T-6316.7, December 17, 1998, submitted May 18, 2000: Analytical Laboratory Report, Determination of the Concentration of PFOS, PFOSA, PFOSAA, and EtFOSE-OH in the Sera and Liver of Crl:CDBR VAF/Plus Rats Exposed to N-Et FOSE, 3M Envi ronmental Laboratory Report No. TOX-098, Laboratory Request No. U2402, 3M Ref. No. T-6316.7, February 6, 2001