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y/l AA - 3JLO DuPont-11418 M UC- &O TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratory Project ID: DuPont-11418 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed on: August 1,2003 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number: Service Code Number: M Page 1255 of 1602 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations f DuPont-11418 APPENDIX BB INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN Pi MALE RATS - 1256 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Genertion Reproduction Evaluations_________________ DuPont-11418 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN Pi MALE RATS OH1 GROUP 0 m g/kg/day A nim al Number E pididym al Sperm Per cauda Per g cauda T e s tic u la r Sperm atids Per te s tis Per g te stis 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 280.6 288.8 263.0 259.5 279.4 264.2 254.9 238.5 252.5 264.2 937.4 782.9 1010.5 1105.8 889.5 857.0 937.3 1077.6 1075.9 1183.7 131.0 133.9 131.5 136.8 136.2 136.8 139.1 135.6 146.8 135.0 87.5 82.6 92.1 87.5 72.8 64.9 95.9 87.0 92.4 81.9 Animal Number 665153 665037 665163 665001 665126 665125 665017 665071 665032 665997 GROUP I I I - O : 10 m g / k g / d a y E pididym al Sperm Per cauda Per g cauda T e s tic u la r Sperm atids Per te s tis Per g te s tis 264.2 252.5 249.0 259.5 256.0 251.4 258.4 253.7 240.8 258.4 998.9 859.5 875.8 1152.9 979.0 1067.2 829.1 1026.2 904.6 918.7 138.5 133.9 137.4 129.8 125.7 138.0 133.3 132.1 138.5 135.0 89.0 81.9 74.5 82.4 89.0 87.8 81.0 86.3 83.1 85.3 - 1257 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN Px MALE RATS GROUP V - 0 : 100 m g / k g / d a y Animal Number 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 Epididymal Sperm Per cauda Per g cauda 256.0 267.7 266.6 261.9 253.7 273.6 235.0 259.5 253.7 256.0 895.2 1007.5 1093.2 1032.6 954.0 1156.7 1132.9 1316.7 1146.3 1279.4 Testicular Spermatids_ Per testis Per g _____________ testis 139.1 132.1 132.7 138.5 122.2 126.9 129.8 136.2 133.9 131.0 82.8 69.8 74.0 74.6 81.9 76.1 84.4 89.5 98.5 92.0 A nim al Number 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 GROUP V I I - 0 : 1 0 0 0 m g / k g / d a y E p i d i d y m a l S p e r m ________ T e s t i c u l a r S p e r m a t i d s Per cauda Per g Per te s tis Per g cauda _________ te stis 239.7 265.4 247.8 244.3 257.2 260.7 244.3 258.4 259.5 244.3 929.2 1131.1 1123.4 955.9 1328.4 898.9 1146.0 892.1 1160.1 1086.4 124.5 139.1 121.6 128.0 126.9 144.4 136.8 125.7 133.3 139.1 82.9 80.7 86.5 87.7 86.5 72.8 75.2 73.2 75.8 80.5 - 1258 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX CC INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN P, FEMALE RATS - 1259 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN P, FEMALE RATS EXPLANATORY NOTES Notes Test Days 74-88 = Cohabitation period -1260 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Px FEMALE RATS GROUP I I - O : 0 m g / k g / d a y ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (d ay s) 665220 665334 665257 a 665175 665336 665192 665232 665307 665246 665289 b 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 21 24 35 22 34 21 25 21 23 21 21 21 21 23 22 21 30 21 23 24 38% 52% 29% 50% 26% 71% 32% 55% 24% 74% 29% 57% 36% 56% 48% 52% 48% 48% 29% 62% 38% 57% 48% 48% 38% 48% 30% 52% 27% 55% 29% 62% 27% 67% 43% 52% 30% 61% 33% 50% 10% 21% 3% 14% 3% 14% 8% 0% 4% 10% 5% 5% 14% 17% 18% 10% 7% 5% 9% 17% 4.00 4.00 4.00 4.00 4.00 4.00 4.00 4.00 5.00 4.50 4.00 4.00 4.00 4.00 5.00 4.00 4.25 4.00 4.00 4.00 1 4 1 2 14 1 5 i 3 1 1 1 1 3 2 1 10 1 3 4 a No evidence of copulation was found but a litter was delivered. To calculate the Precoital Interval, the day of copulation was assumed to be the last estrus during cohabitation; the days of persistent diestrus that followed were excluded from calculations since the animal was pregnant (diestrus) and thus, was not cycling normally. b Evidence of copulation detected, but animal did not deliver a litter. -1261 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Px FEMALE RATS GROUP I V - 0 : 10 m g / k g / d a y ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE PRECOITAL LENGTH INTERVAL (d a y s ) {d a y s ) 665212 665180 665292 665187 665205 665263 a 665210 665181 a 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 25 22 22 21 24 23 21 21 25 21 26 24 23 23 23 23 22 23 21 26 8% 76% 32% 64% 23% 64% 24% 48% 25% 75% 17% 70% 38% 48% 38% 62% 28% 64% 33% 52% 35% 62% 38% 58% 22% 74% 26% 65% 35% 57% 35% 52% 23% 68% 48% 52% 29% 71% 42% 58% 16% 5% 14% 29% 0% 13% 14% 0% 8% 14% 4% 4% 4% 9% 9% 13% 9% 0% 0% 0% 4..25 4..00 4,.00 4,.00 4 .00 4..00 4,.00 4..00 4,.00 4,.67 4,.00 4,.00 4,.00 4,.00 4..25 4,.00 4..25 4,.00 4..50 5 ,.0 0 5 2 2 1 4 1 1 2 5 i 6 4 3 3 3 3 2 3 1 6 a No evidence of copulation was found but a litter was delivered. To calculate the Precoital Interval, the day of copulation was assumed to be the last estrus during cohabitation; the days of persistent diestrus that followed were excluded from calculations since the animal was pregnant (diestrus) and thus, was not cycling normally. - 1262 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Pi FEMALE RATS GROUP V I - 0 : 1Q0 m g / k g / d a y ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 a 665207 665273 665274 665272 665195 665314 665316 665173 NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE PRECOITAL LENGTH INTERVAL ( d a y s ) ________( d a y s ) 23 30% 70% 0% 4.00 3 24 38% 63% 0% 4.00 4 22 27% 68% 5% 4 .2 5 2 22 36% 55% 9% 4 .0 0 2 25 28% 68% 4% 4 .0 0 5 21 19% 71% 10% 4.00 1 22 23% 64% 14% 5.00 2 25 36% 64% 0% 4.67 5 24 33% 67% 0% 4.00 4 22 32% 64% 5% 3.40 2 23 30% 52% 17% 4.00 3 23 22% 61% 17% 5.00 1 21 33% 52% 14% 4 .0 0 1 21 24% 57% 19% 5.00 1 21 38% 48% 14% 4.00 1 22 41% 45% 14% 4.00 2 24 46% 50% 4% 4.00 4 21 14% 71% 14% 4.67 1 32 31% 59% 9% 3.83 12 24 46% 54% 0% 4.00 4 aEvidence of copulation was found, but animal did not deliver a litter. - 1263 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN Px FEMALE RATS GROUP V I I I - 0 : 1 0 0 0 m g / k g / d a y ANIMAL NUMBER NUMBER OF DAYS OF DATA COLLECTION PERCENT OF DAYS IN ESTRUS PERCENT OF DAYS IN DIESTRUS PERCENT OF DAYS IN PROESTRUS MEAN CYCLE LENGTH (days) PRECOITAL INTERVAL (d a y s ) 665296 a 665193 665320 a 665315 665318 665279 665224 b 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 a 24 33% 54% 13% 4.00 24 21% 71% 8% 5.33 23 26% 65% 9% 4.67 21 38% 48% 14% 4.00 24 29% 54% 17% 4.00 22 18% 64% 18% 4.67 21 24% 71% 5% 5.00 21 14% 67% 19% 4.00 21 19% 62% 19% 4.00 23 39% 52% 9% 4.00 24 42% 50% 8% 4.00 22 23% 68% 9% 4.25 21 19% 62% 19% 4.67 24 33% 58% 8% 4.75 23 35% 57% 9% 4.00 26 15% 73% 12% 4.25 24 25% 63% 13% 4.75 21 24% 76% 0% 4.00 22 23% 64% 14% 4.00 24 25% 67% 8% 4.50 4 4 3 1 4 2 1 1 1 3 4 2 1 4 3 6 4 1 2 5 a No evidence of copulation was found but a litter was delivered. To calculate the Precoital Interval, the day of copulation was assumed to be the last estrus during cohabitation; the days of persistent diestrus that followed were excluded from calculations since the animal was pregnant (diestrus) and thus, was not cycling normally. bEvidence of copulation was found, but animal did not deliver a litter. - 1264 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX DD INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN P, FEMALE RATS - 1265 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Pi FEMALE RATS EXPLANATORY NOTES Notes Test Days 74-88 = Cohabitation period Abbreviations D = Diestrus E = Estrus P = Proestrus X = No sample or stage could not be defined from sample. - 1266 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Pi FEMALE RATS GROUP I I - O : 0 m g / k g / d a y DuPont-11418 ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 D jjgj 665246 665289 665264 665185 665206 665306 b dT du BEq D 1 |D ^ | D|D| 665226 665198 665249 665284 665240 665203 i DA Y 65 166 167 |~68~ DD D m l 72 173174 75 7 6 | 77 |~78~ 79 80 81 pS D D|D [ d D P 3 |H ( D D m 1 D D ^ 9 d | D _ D D ~D~ f l j i l l ED 82 83 84 85 86 D I P f p ~D~ D 87 88 D ' tT D L L D H p P D D ~D~ D ~D~ ~D~ ~D~ i P l ED ___ ~D~ ~D~ :'E E " : E D D S S E B ~ P 7d~ 3 E D D BBS 1 D E ' E D i d id mm I __P D | D | D E D >p a E D d ma . s ; D 'D ; p D U L E P E fD U S P E D j D p a E D D P E D D I D W B D" E . D D D P n r E D *57 P E D pH jD D dba 1 E D D f c p f a l M S D "E n DD M E H P ' D IS L ~D~ D M D 1 D D H s lls i D | D 1 3 ____ Company Sanitized. Does not contain TSCA CBI aNo evidence o f copulation was found but a litter was delivered. Evidence of copulation was found but animal did not deliver a litter. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Px FEMALE RATS GROUP I V - 0 : 10 m g / k g / d a y DuPont-11418 ANIMAL NUMBER 5 4 1 5 5 1 5 6 1 5 7 1 5 8 60 62 665212 D D DD 665180 D 665292 D D 665187 665205 665263 665210 DD DD D |D D D lD D DDDD DD 665181 a | 665248 DD DD 665293 665329 665290 665253 665286 665281 665186 D E E D "Di s EDDDE D D P E d | D D D E D "Dl DDE DE DDE DDD DDE E DD D D DD DD D DD 665330 665294 665244 P E S m D : P E ll ' E - J b .E ,E r n D D 1 E 665258 m W D 1D m D TEST DAYS 671m 69 P ] [tT172[73174 [75l 76 [77 [78] m 80 81 82 83 84 85 86 87 88 D P B a D D p 5B D~ D D ' D j D E D B B D E D D 1P D P D 1d ] E D B I P L_ I E DP ED P 1 1 _E_ D D , D E 1L T T ~D~ _ ? D j D Bi s D M i E D E D 1 D E ii JJ P E I T Q tT K E D D E L D i| d T E a D D . p D E D pp~ E E D D- p 31 D D iL E D pE D D p p ~ R i D A; m Id D D ._ E _ -D J i r l D ||3 D D | D ] ~D~~ D ~D~ ~D~ 151~D~ ~D~ ~D~ ~D~ ~D~ D H I I T d "~5~7D ~ ~D~ ~P~ '*D~: E E rr r D~ D-: d B ,D m P __ ~D~ ~D~ ~D~ ~D~ D E IB DPE ,D " J? E DE D ,i l 1D A j D P D I B S .. Dd E E .D j D E D I d ] E p ___ ii___ !1 D . E r:p D- .E s ~D~ E I d -D j D I I 1 D E Pi d mm i D "D 1V DD E msj " D 1D E i u BM E ___E_ HI D 9 Company Sanitized. Does not contain TSCA CBI No evidence of copulation was found but a litter was delivered. )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________ INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Px FEMALE RATS GROUP V I - 0 : 10 0 m g / k g / d a y ) DuPont-11418 ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 D DD DD DD D md DD DD D D D DD DD D D DD TEST DAYS [66 71 [72 \2 L 74] 75 [76]121 78 79 80 81 82 83 84 85 D LP, ;E ' d " 8 - E DD DD DD DD D D E D E g D E fB E LLL D J? B1 D de P ___ m mU-L 'a D E D i r .d E DD P g ,D D D J T DE D D D- d B L D I E -D D IB B a g 1 D D E P D g U U . E D "d LJ B D "D- P E D D \ I D E D' D P L g D D. P D D JL D E D D P E- D D D ?E E D D B D o IL LDL D . cr J L D K IL "5 " D E . D D ~pT ~D~ T T ~D~ ~d "MSb D D D ;E E D JP J E" in Company Sanitized. Does not contain TSCA CBI a Evidence of copulation was found but animal did not deliver a litter. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN Pi FEMALE RATS GROUP V I I I - 0 : 1 0 0 0 m g / k g / d a y 665296 a Df p E 665193 D 1 D E 665320 a D D 5 P E 665315 E E D "D " E 665318 ' E D PE 6 6 5 2 7 9 D ! ;Dv P E D 665224 b T 5 j D P E D 665254 665245 E P D E D D D] P D 665322 [D D E E IS 665214 i f f D lu i p E 665321 D E l o i DV 665171 665265 D i P B D tSy E D Fd I E 665169 D 1 D p E [D j 6 6 5 1 9 1 ~D~j D D Sj P 6 6 5 2 3 1 | g :.' D D D P 665255 D i f f ' D D Sd I 665213 D m B 665280 a; D fiB D;Ri DD DuPont-11418 Company Sanitized. Does not contain TSCA CBI aNo evidence of copulation was found but a litter was delivered. Evidence of copulation was found but animal did not deliver a litter. H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX EE INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pj GENERATION - 1271 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pj GENERATION EXPLANATORY NOTES Abbreviation - = N o Data - 1272Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL MATING DATA AND GESTATION LENGTH: Pa GENERATION GROUPS : 11-0,1-0 DOSE: 0 MG/KG/DAY DuPont-! FEMALE ANIMAL# 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 MALE #1 ANIMAL# 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 PLUG OBSERVED + + - 4 + + 4 4 + 4 4 4 4 4 4 4 4 + + 4 MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + 4 4 4 4* + 4 4 4 - 4 4 4 4 4 4 4 4 + 4 GESTATION LENGTH(d a y s) 22 22 -- 0 22 22 23 23 22 22 -- 23 22 22 22 22 22 22 22 22 22 aGestation length could not be calculated since no evidence of copulation was observed. - 1273 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL M A T I N G D A T A A N D GESTA T I O N LENGTH: Pi GENER A T I O N GROUPS: IV-0,III-0 DOSE: 10 M G / K G / D A Y DuPont-11418 FEMALE ANIMAL# 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 MALE #1 ANIMAL# 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 PLUG OBSERVED + + + + - + + + + + + + + + + + + MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + + + + + + + + + GESTATION LENGTH(days) 23 22 24 22 22 _a 22 a 23 23 23 22 23 22 23 23 22 23 23 23 Gestation length could not be calculated since no evidence of copulation was observed. - 1274 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations . INDIVIDUAL M A T I N G DAT A A N D G ESTATION LENGTH: Pi GENER A T I O N GROUPS: VI-O/V-O DOSE: 100 MG/KG/DAY DuPont-11418 FEMALE ANIMAL# 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 MALE #1 ANIMAL# 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 PLUG OBSERVED + 4+ + 4* 4* + 4* + + + + + + + + + + 4- MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + 4* + 4- - + 4+ + + + + 4- GESTATION LENGTH(days) 23 23 23 22 23 22 23 23 23 23 22 -- 22 23 23 22 22 23 22 22 - 1275- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL M A T I N G DATA A N D G E S T A T I O N LENGTH: P! GENER A T I O N GROUPS: VIII-0,VII-0 DOSE: 1000 MG/KG/DAY DuPont-11418 FEMALE ANIMAL# 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 MALE #1 ANIMAL# 665050 665134 665022 665105 665102 665161 665133 665157. 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 PLUG OBSERVED - - + + + + + + + + + + + + + + + - MALE #2 ANIMAL# PLUG OBSERVED LITTER PRODUCED + + + + + + + + + + + + + + + 4- + + GESTATION LENGTH(days) a 22 -- a 22 22 22 -23 23 22 22 22 23 23 22 23 22 22 22 -- a ---- .... a Gestation length could not be calculated since no evidence of copulation was observed. - 1276 Company Sanitized. Does not contain TSCA CB1 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX EF INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION - 1277 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION EXPLANATORY NOTES Abbreviations NP = Not Pregnant -- = No Data - 1278 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL IMPLANTATION SIT E DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION GROUPS: I I - O DOSE: 0 MG/KG/DAY A nim al Number A nim al S ta tu s Pups Born Number o f Im plantation S ites Im plantation E fficiency 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 NP 15 14 6 12 15 14 13 14 13 -- 10 13 16 15 13 16 15 14 13 13 16 17 9 12 16 14 15 16 14 -- 14 14 16 16 15 18 16 16 13 13 93.8 82.4 66.7 100.0 93.8 100.0 86.7 87.5 92.9 -- 71.4 92.9 100.0 93.8 86.7 88.9 93.8 87.5 100.0 100.0 - 1279 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL IMPLANTATION S IT E DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION GROUPS: I V - 0 DOSE: 10 MG/KG/DAY A nim al Number A nim al S tatus Pups Born Number of Im plantation S ites Im plantation E fficiency 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 12 13 14 15 37 14 16 9 15 16 18 12 13 13 14 4 16 13 16 13 15 14 18 9 10 16 16 12 19 12 14 14 16 14 17 77 13 15 92.3 93.3 42.9 87.5 60.0 88.9 92.3 92.9 2 5 .0 81.3 86.7 77.8 90.0 100.0 63.2 85.7 87.5 82.4 100.0 86.7 - 1280Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL IMPLANTATION S I T E DATA AND IMPLANTATION EFFICIENCY: Pj. GENERATION GROUPS: V I -0 DOSE: 100 MG/KG/DAY A nim al Number A nim al S tatus Pups Born Number of Im plantation S ites Im plantation E fficiency 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 NP 18 5 10 12 14 17 13 5 13 10 12 ----14 7 14 11 15 15 15 17 19 5 16 14 14 17 15 5 16 13 13 -- 16 9 14 13 18 16 16 17 94.7 100.0 62.5 85.7 100.0 100.0 86.7 100.0 81.3 76.9 92.3 -- 87.5 77.8 100.0 84.6 83.3 93.8 93.8 100.0 - 1281 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Pi GENERATION GROUPS : V I I I - 0 DOSE: 1 0 0 0 MG/KG/DAY A nim al Number A nim al S tatus Pups Bom Number of Im plantation S ites Im plantation E fficiency 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 NP 13 15 15 12 18 18 -- 15 12 11 13 15 6 16 15 14 14 17 16 17 13 16 15 12 18 20 -- 16 14 13 13 15 12 16 15 14 15 19 19 18 100 .0 93 .8 100 .0 100 .0 100 .0 90;.0 --93 ,.8 85..7 84..6 100 .0 100 .0 50..0 1 0 0 . .0 1 0 0 ..0 100. 0 93 ..3 89. 5 84. 2 94. 4 - 1282 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX GG INDIVIDUAL PUP SURVIVAL: Fj GENERATION - 1283 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fi GENERATION EXPLANATORY NOTES Abbreviations NP = = Not Pregnant No Data DuPont-11418 - 1284Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER BORN 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 (NP) 15 14 6 12 15 14 13 14 13 10 13 16 15 13 16 15 14 13 13 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 15 15 8 8 14 14 8 8 6666 12 12 8 8 15 15 8 8 14 13 8 8 13 13 8 8 14 14 8 8 13 13 8 8 -_ - - 10 10 8 8 13 13 87 16 16 8 8 15 15 8 8 13 13 8 8 16 16 8 8 15 15 8 8 14 14 8 8 13 13 8 8 13 13 8 8 DAY 14 8 8 6 8 8 8 8 8 8 - 8 7 8 8 8 8 8 8 8 8 DAY 21 8 8 6 8 8 8 8 8 8 8 7 8 8 8 8 8 8 8 8 - 1285 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER BORN 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 (NP) 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 7 8 2 8 8 5 5 6 8 - 6 6 6 8 10 10 8 6 5 3 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 7744 8844 2222 8844 8844 5444 5544 6644 8844 - --6 644 6 64 4 6644 8844 10 10 5 5 10 10 4 4 8 84 4 6 64 4 5544 3333 DAY 14 4 4 2 4 4 4 4 4 4 4 4 4 4 5 4 4 4 4 3 DAY 4 4 2 4 4 4 4 4 4 4 4 4 4 5 4 4 4 4 3 - 1286 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER BORN 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 (NP) 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 8 6 4 4 7 9 8 8 5 - 4 7 10 7 3 6 7 8 8 10 NUMBER OF FEMALE 'PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 884 4 664 4 444 4 444 4 7744 994 4 884 4 884 4 554 4 - --444 4 774 3 10 10 4 4 774 4 333 3 664 4 774 4 884 4 884 4 10 10 5 5 DAY 4 4 4 4 4 4 4 4 4 4 3 4 4 3 4 4 4 4 5 DuPont-11418 DAY 21 4 4 4 4 4 4 4 4 4 4 3 4 4 3 4 4 4 4 5 - 1287 Company Sanitized. Does not contain TSCA CBI /"""S H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER SEX RATIO (MALES) 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 (NP) 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0.47 0.57 0.33 0.67 0.53 0.36 0.38 0.43 0.62 0.60 0.46 0.38 0.53 0.77 0.63 0.53 0.43 0.38 0.23 NUMBER OF PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 92.9 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 1288 Company Sanitized. Does not contain TSCA CBI /"`" N H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY WIMAL NOMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 (NP) 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 NUMBER OF MALE PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 80.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1289Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 (NP) 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 NUMBER OF FEMALE PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 75.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1290 Company Sanitized. Does not contain TSCA CBI /"N H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: IV-0 DOSE: 10 MG/KG/DAY BORN 12 14 3 14 10 16 12 13 4 13 13 14 9 16 12 12 14 14 7 13 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 12 12 8 8 12 12 8 8 333 3 14 13 8 8 998 8 16 16 8 8 12 12 8 8 13 13 8 8 0 13 13 8 8 13 13 8 8 14 14 8 8 99 8 8 16 16 8 8 12 12 8 8 12 12 8 8 14 14 8 8 14 14 8 8 77 7 7 13 13 8 8 DAY 14 8 8 3 8 8 8 8 8 8 8 8 8 8 8 8 8 8 7 8 DAY 21 8 8 3 8 8 8 8 8 8 8 8 8 8 8 8 8 8 7 8 - 1291 Company Sanitized. Does not contain TSCA CBi H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: FlA GENERATION GROUP: IV-0 DOSE: 10 M G / K G / D A Y BORN 8 10 2 7 4 8 6 9 4 2 5 8 4 8 5 5 6 11 3 6 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 884 4 8 84 4 2222 764 4 4444 8 84 4 6 64 4 994 4 0- - - 222 2 554 4 884 4 444 4 884 4 5 54 4 5544 6644 11 11 5 5 333 3 664 4 DAY 14 4 4 2 4 4 4 4 4 - 2 4 4 4 4 4 4 4 5 3 4 DAY 21 4 4 2 4 4 4 4 4 - 2 4 4 4 4 4 4 4 5 3 4 - 1292 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: PlA GENERATION GROUP: IV-0 DOSE: 10 M G / K G / D A Y BORN 4 4 1 7 6 8 6 4 oa 11 8 6 5 8 7 7 8 3 4 7 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 4 44 4 44 1 1 .1 7 74 554 8 84 6 64 4 44 - 11 11 88 66 55 88 77 77 88 33 44 77 6 4 4 4 4 4 4 4 3 4 4 4 4 1 4 4 4 4 4 6 4 4 4 4 4 4 4 3 4 4 ' 14 DAY : 44 44 11 44 44 44 44 44 66 44 44 44 44 44 44 44 33 44 44 No female pups were born; data were excluded from statistical analyes. - 1293 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: IV-0 DOSE: 10 MG/KG/DAY NUMBER OF PUPS SEX RATIO (MALES) 0 .67 0 .71 0 .67 0 .50 0 .40 0 .50 0 ..50 0 ..69 1 ..00 0 ,.15 0 ..38 0..57 0 ..44 0 ..50 0 ..42 0 .,42 0 ..43 0.,79 0 ..43 0 ..46 % BORN ALIVE 100 .0 85 .7 100,.0 100..0 90,.0 100..0 100..0 100..0 0..0 100..0 100.,0 100.,0 100. 0 100..0 100..0 100. 0 100. 0 100. 0 100. 0 100. 0 0-4 DAY VIABILITY 100 .0 100 .0 100 .0 92 .9 100 .0 100 .0 100 .0 100..0 - 100..0 100..0 100.,0 100.,0 100.,0 100..0 100. 0 100. 0 100. 0 100. 0 100. 0 DuPont-11418 LACTATION INDEX 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100 .0 100,.0 100 .0 100 ,.0 100..0 100..0 100..0 100.,0 100..0 100 .,0 100..0 100 .0 - 1294 Company Sanitized. Does n o t c o n ta in TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: IV-0 DOSE: 10 MG/KG/DAY % BORN AL 100.0 80.0 100.0 100.0 100.0 100.0 100.0 100.0 0.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 NUMBER OF MALE PUPS 0-4 DAY VIABILITY 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1295 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: IV-0 DOSE: 10 MG/KG/DAY NUMBER OF FEMALE PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 83.3 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1296Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER BORN 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 (NP) 665207 665273 665274 665272 665195 665314 665316 665173 18 5 10 12 14 17 13 5 13 10 12 14 7 14 11 15 15 15 17 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 17 17 55 10 10 12 12 14 14 16 16 13 13 55 13 13 10 10 12 12 -14 14 77 14 14 11 11 15 15 15 15 15 15 17 17 88 5- 5 88 88 88 88 88 55 88 88 88 88 77 88 88 88 88 88 88 DAY 14 7 5 8 8 8 8 8 5 8 8 8 8 7 8 8 8 8 8 8 DAY 21 7 5 8 8 8 8 8 5 8 8 8 8 7 8 8 8 8 8 8 ygdpinnwny - 1297 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER BORN 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 (NP) 665207 665273 665274 665272 665195 665314 665316 665173 8 1 9 4 6 10 7 4 6 4 8 - 5 5 6 6 9 7 10 13 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY ' 884 4 111 1 997 7 444 4 664 4 994 4 774 4 444 4 664 4 444 4 8 84 4 -- - - 553 3 555 5 664 4 664 4 994 4 7744 10 10 4 4 13 13 4 4 DAY 14 4 1 7 4 4 4 4 4 4 4 4 3 5 4 4 4 4 4 4 DAY 21 4 1 7 4 4 4 4 4 4 4 4 3 5 4 4 4 4 4 4 - 1298 Company Sanitized. Does not contain TSCA CBI H.-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER BORN 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 (NP) 10 4 1 8 8 7 6 1 7 6 4 9 2 8 5 6 8 5 4 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY 7 9944 4444 1 11 1 8844 8844 7744 6 64 4 1111 7744 6 64 4 4444 - 995 5 2222 884 4 554 4 664 4 8844 5544 4444 DAY 14 3 4 1 4 4 4 4 1 4 4 4 - 5 2 4 4 4 4 4 4 DAY 21 3 4 1 4 4 4 4 1 4 4 4 5 2 4 4 4 4 4 4 - 1299 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER SEX RATIO (MALES) 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 (NP) 665207 665273 665274 665272 665195 665314 665316 665173 0.44 0.20 0.90 0.33 0.43 0.59 0.54 0.80 0.46 0.40 0.67 - 0.36 0.71 0.43 0.55 0.60 0.47 0.67 0.76 NUMBER OF PUPS % BORN ALIVE 94.4 100.0 100.0 100.0 100.0 94.1 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 LACTATION INDEX 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1300Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 (NP> 665207 665273 665274 665272 665195 '665314 665316 665173 NUMBER OF MALE PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 90.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1301 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FlA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 (NP) 665207 665273 665274 665272 665195 665314 665316 665173 NUMBER OF FEMALE PUPS % BORN ALIVE 90.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX 75.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1302 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rate with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER BORN 665296 665193 665320 665315 665318 665279 665224 (NP) 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 13 15 15 12 18 18 - 15 12 11 13 15 6 16 15 14 14 17 16 17 NUMBER OF PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 ' 4 DAY 7 13 13 8 8 15 15 8 8 15 14 8 8 11 11 8 8 18 18 8 8 17 17 8 8 -15 15 8 8 12 12 8 8 11 11 8 8 13 13 8 8 15 15 8 8 6 66 6 16 15 8 8 15 15 8 8 14 14 8 8 14 14 8 8 17 17 8 8 16 16 8 8 16 16 8 8 DAY 14 8 8 8 8 8 8 8 8 8 8 8 6 8 8 8 8 8 8 8 DAY : 8 8 8 8 8 8 8 8 8 8 8 6 8 8 8 8 8 8 8 - 1303 Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER BORN 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 (NP) 7 8 8 5 10 8 5 8 8 7 9 3 9 6 10 7 11 7 8 NUMBER OF MALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY ' 7 74 4 884 4 8744 5544 10 10 4 4 774 4 5544 8 84 4 8855 7744 9944 3333 9 84 4 6 644 10 10 4 4 7744 1 1 11 4 4 1 744 1 744 DAY 14 4 4 4 4 4 4 4 4 5 4 4 3 4 4 4 4 4 4 4 DAY 21 4 4 4 4 4 4 4 4 5 4 4 3 4 4 4 4 4 4 4 ^ m*\. - 1304 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER BORN 665296 665193 665320 665315 665318 665279 665224 (NP) 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 6 7 7 7 8 10 10 4 3 6 6 3 7 9 4 7 6 9 9 NUMBER OF FEMALE PUPS BORN PRECULLING POSTCULLING ALIVE DAY 4 DAY 4 DAY ' 6644 77 4 4 77 4 4 6644 8844 10 10 4 4 10 10 4 4 4444 3333 6644 6644 3333 7744 9944 4444 7744 6644 9944 9944 DAY 14 4 4 4 4 4 4 4 4 3 4 4 3 4 4 4 4 4 4 4 DAY 21 4 4 4 4 4 4 4 4 3 4 4 3 4 4 4 4 4 4 4 - 1305 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER SEX RATIO (MALES) 665296 665193 6S5320 665315 665318 665279 665224 (NP) 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 0..54 0..53 0..53 0..42 0..56 0..44 0..33 0..67 0..73 0..54 0..60 0..50 0..56 0..40 0,.71 0..50 0..65 0..44 0..47 NUMBER OF PUPS % BORN ALIVE 100..0 100..0 100..0 91.,7 100..0 94.,4 100.,0 100.,0 100.,0 100.,0 100..0 100..0 100..0 100..0 100..0 100..0 100..0 100,.0 94..1 0-4 DAY VIABILITY 100..0 100..0 93..3 100..0 100,.0 100,.0 100,.0 100..0 100,.0 100..0 100..0 100..0 93..8 100..0 100..0 100..0 100..0 100..0 100..0 DuPont-11418 LACTATION INDEX 100 .0 100 .0 100 .0 100 .0 100 .0 100..0 100..0 100 .0 100..0 100..0 100..0 100..0 100..0 100..0 100,.0 100..0 100..0 100..0 100..0 - 1306Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 (NP) NUMBER OF MALE PUPS % BORN ALIVE 100.0 100.0 100.0 100.0 100.0 87.5 - 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 87.5 0-4 DAY VIABILITY 100.0 100.0 87.5 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.9 100.0 100.0 100.0 100.0 100.0 100.0 LACTATION INDEX. 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 DuPont-11418 - 1307 Company Sanitized. Does not contain TSCA CBI FI-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _____________________ DuPont-11418 INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 (NP) 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 NUMBER OF FEMALE PUPS % BORN ALIVE 100.0 100.0 100.0 85.7 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 0-4 DAY VIABILITY 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 . LACTATION INDEX 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 - 1308 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX HH INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fi GENERATION I - 1309 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL LITTER CLINICAL OBSERVATIONS: FIA GENERATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 665220 NO ABNORMALITIES DETECTED 665334 NO ABNORMALITIES DETECTED 665257 NO ABNORMALITIES DETECTED 665175 NO ABNORMALITIES DETECTED 665336 NO ABNORMALITIES DETECTED 665192 NO ABNORMALITIES DETECTED 665232 NO ABNORMALITIES DETECTED 665307 NO ABNORMALITIES DETECTED 665246 NO ABNORMALITIES DETECTED 665264 NO ABNORMALITIES DETECTED 665185 NO ABNORMALITIES DETECTED 665206 NO ABNORMALITIES DETECTED 665306 NO ABNORMALITIES DETECTED 665226 NO ABNORMALITIES DETECTED 665198 NO ABNORMALITIES DETECTED 665249 NO ABNORMALITIES DETECTED 665284 NO ABNORMALITIES DETECTED 665240 NO ABNORMALITIES DETECTED 665203 NO ABNORMALITIES DETECTED DuPont-11418 - 1310Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL LITTER CLINICAL OBSERVATIONS: FIA GENERATION GROUP: IV-0 DOSE: 10 MG/KG/DAY ANIMAL LACTATION NUMBER DAY SIGN INCIDENCE OBSERVATIONS 665212 NO ABNORMALITIES DETECTED 665180 NO ABNORMALITIES DETECTED 665292 NO ABNORMALITIES DETECTED 665187 NO ABNORMALITIES DETECTED 665205 NO ABNORMALITIES DETECTED 665263 NO ABNORMALITIES DETECTED 665210 NO ABNORMALITIES DETECTED 665181 NO ABNORMALITIES DETECTED 665248 ALL PUPS BORN DEAD 665293 NO ABNORMALITIES DETECTED 665329 NO ABNORMALITIES DETECTED 665290 NO ABNORMALITIES DETECTED 665253 NO ABNORMALITIES DETECTED 665286 NO ABNORMALITIES DETECTED 665281 NO ABNORMALITIES DETECTED 665186 NO ABNORMALITIES DETECTED 665330 NO ABNORMALITIES DETECTED 665294 NO ABNORMALITIES DETECTED 665244 NO ABNORMALITIES DETECTED 665258 NO ABNORMALITIES DETECTED DuPont-11418 - 1311 Company Sanitized. Does not contain TSCA CBI H-25425: Subctironic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL LITTER CLINICAL OBSERVATIONS: FIA GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL LACTATION SIGN NUMBER DAY INCIDENCE OBSERVATIONS 6S5338 DAY 7 1 OF 8 SMALL WHOLE BODY LITTER SUMMARY: 1 SMALL WHOLE BODY 665219 NO ABNORMALITIES DETECTED 665267 NO ABNORMALITIES DETECTED 665325 NO ABNORMALITIES DETECTED 665331 NO ABNORMALITIES DETECTED 665217 NO ABNORMALITIES DETECTED 665227 NO ABNORMALITIES DETECTED 665262 NO ABNORMALITIES DETECTED 665247 NO ABNORMALITIES DETECTED 665243 NO ABNORMALITIES DETECTED 665312 NO ABNORMALITIES DETECTED 665207 NO ABNORMALITIES DETECTED 665273 NO ABNORMALITIES DETECTED 665274 NO ABNORMALITIES DETECTED 665272 NO ABNORMALITIES DETECTED 665195 NO ABNORMALITIES DETECTED 665314 NO ABNORMALITIES DETECTED 665316 NO ABNORMALITIES DETECTED 665173 NO ABNORMALITIES DETECTED DuPont-11418 - 1312 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL LITTER CLINICAL OBSERVATIONS: P1A GENERATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL LACTATION SIGN NUMBER DAY INCIDENCE OBSERVATIONS 665296 NO ABNORMALITIES DETECTED 665193 NO ABNORMALITIES DETECTED 665320 DAY 0 1 OF 15 SMALL WHOLE BODY LITTER SUMMARY: 1 SMALL WHOLE BODY 665315 NO ABNORMALITIES DETECTED 665318 NO ABNORMALITIES DETECTED 665279 NO ABNORMALITIES DETECTED 665254 NO ABNORMALITIES DETECTED 665245 NO ABNORMALITIES DETECTED 665322 NO ABNORMALITIES DETECTED 665214 NO ABNORMALITIES DETECTED 665321 NO ABNORMALITIES DETECTED 665171 NO ABNORMALITIES DETECTED 665265 NO ABNORMALITIES DETECTED 665169 NO ABNORMALITIES DETECTED 665191 NO ABNORMALITIES DETECTED 665231 NO ABNORMALITIES DETECTED 665255 NO ABNORMALITIES DETECTED 665213 NO ABNORMALITIES DETECTED 665280 NO ABNORMALITIES DETECTED DuPont-11418 - 1313 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX H INDIVIDUAL PUP WEIGHTS: Fj GENERATION - 1314 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS: Fi GENERATION EXPLANATORY NOTES Abbreviations NP = Not Pregnant Blank Spaces = No Data DuPont-11418 - 1315Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ DuPont-11418 INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 0 Group : I I -0 Dose : 0 mg/k g/d ay Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 8 9 10 665220 3 7.3 7.1 7.5 6.6 7.3 7.0 7.2 S 6.4 6.5 6.6 6.6 6.5 6.7 6.1 7.0 665334 3 6.8 6.7 6.4 7.1 6.2 6.8 6.4 6.2 2 6.0 6.1 5.3 6.6 6.0 5.8 665257 3 9.0 8.2 2 7.8 8.5 8.0 8.0 665175 3 6.8 7.0 7.1 7.0 7.5 7.6 7.2 7.7 2 6.3 7.2 6.8 7.2 665336 3 7.0 6.8 7.2 6.7 7.3 7.5 7.7 7.1 2 6.5 6.8 6.7 6.3 6.5 6.6 6.4 665192 3 7.8 8.0 7.3 7.8 8.1 2 7.4 8.1 6.6 6.6 7.2 7.0 6.5 7.6 7.3 665232 3 7.8 7.5 7.8 7.8 7.5 2 6.9 7.0 4.8 7.1 6.2 7.4 7.4 6.7 665307 3 7.6 7.0 7.3 7.9 7.1 8.1 2 7.0 6.7 7.1 7.9 7.5 7.1 7.1 7.1 665246 3 6.7 6.9 6.7 6.3 6.9 6.6 6.7 6.7 2 6.0 6.4 6.3 6.1 5.6 6 6 5 2 8 9 3 NP 2 NP 665264 3 8.8 8.4 8.2 7.5 8.4 8.4 2 8.4 7.3 6.3 7.7 665185 3 7.8 7.0 7.0 7.2 5.6 7.1 2 6.3 7.1 6.5 6.3 6.5 7.1 6.1 665206 3 6.8 7.0 7.1 6.9 6.7 7.2 2 6.5 6.1 6.6 5.8 6.0 5.9 6.3 7.1 6.6 665306 3 6.5 6.9 6.8 6.0 6.0 6.0 5.8 6.0 2 5.8 5.9 5.4 5.9 6.2 5.6 6.0 665226 3 7.1 7.2 7.2 7.2 6.9 6.6 6.7 6.8 6.9 2 5.2 6.6 6.9 665198 3 5.8 5.7 6.5 6.1 6.0 5.7 5.6 6.3 6.2 2 5.9 5.4 5.8 5.5 5.6 5.7 665249 3 6.3 5.8 6.0 6.0 6.2 5.6 6.1 6.5 2 6.0 6.0 6.3 5.9 5.7 5.8 5.8 665284 3 7.0 7.3 7.4 6.7 6.9 7.1 2 6.7 5.8' 6.9 7.1 6.5 6.3 6.8 6.0 665240 3 7.1 6.5 6.4 6.9 7.2 2 6.4 7.0 5.8 6.6 7.2 7.0 6.6 6.5 665203 3 7.5 6.8 7.1 2 6.7 6.4 6.4 6.0 6.8 6.7 5.2 6.3 6.6 5.8 7.1 6.1 6.0 - 1316Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP WEIGHTS (grams): Fi GENERATION Lactation Day 0 Group : IV-0 Animal Pup Number Sex 1 2 3 4 Dose: 10 mg/kg/day Pup Number 567 8 10 11 665212 665180 665292 665187 665205a 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 3 7.6 7.2 7.6 9 7.8 6.9 7.3 3 7.0 7.1 6.5 9 6.5 6.8 6.6 3 9.0 8.2 9 8.5 3 5.9 7.2 6.4 9 5.9 6.1 6.4 3 8.6 7.3 7.6 9 7.0 6.4 7.1 3 8.5 8.4 6.7 9 7.3 6.9 7.3 3 6.8 6.4 6.4 9 6.5 5.5 6.1 3 7.5 6.6 7.6 9 6.6 6.1 6.1 3 No L i v e Pu p s 9 No L i v e P u p s <5 7 . 8 7 . 6 9 7.1 7.5 7.3 3 7.9 8.0 7.9 9 7.6 6.4 7.7 3 6.4 6.3 6.1 9 6.2 6.0 6.3 3 8.6 8.2 7.6 9 8.30 7.40 7.10 3 7.00 7.50 7.10 9 6.50 6.50 6.70 3 8.00 7.80 7.30 9 7.80 7.30 7.90 3 8.20 8.30 7.80 9 7.80 7.30 8.20 3 6.50 5.40 6.80 9 6.00 5.60 5.90 3 7.90' 7.80 7.90 9 7.70 7.70 7.00 3 7.80 7.60 7.60 9 7.30 7.20 7.20 3 7.30 7.50 8.10 9 6 . 9 0 7 .2Q 7 . 1 0 8.2 7.0 7.8 6.5 6.3 6.3 6.7 7.6 7.8 6.2 5.3 6.7 6.1 7.1 7.6 7.7 6.3 6.3 7.6 8.00 7.10 6.90 7.80 7.30 8.00 7.70 6.60 6.10 7.30 7.40 7.70 6.40 7.6 6.8 6.6 6.2 7.4 8.1 7.4 6.1 6.5 7.3 7.1 7.5 7.4 6.4 5.9 7.30 7.00 6.80 7.90 7.60 8.30 7.70 7.00 6.30 6.90 8.00 6.80 7.5 7.1 6.3 6.1 7.2 7.2 7.2 6.6 6.2 7.3 7.1 7.1 6.5 5.5 6.00 6.80 7.70 8.00 6.90 5.40 7.40 4.50 7.00 7.5 6.6 6.2 6.1 7.8 6.9 7.2 7.6 6.8 6.1 7.60 7.50 7.50 6.80 5.80 6.90 7.30 7.8 6.9 7.6 5.9 7.7 6.60 7.0 6.80 7.10 7.30 7.3 6.7 7.40 6.50 5.70 7.90 7.30 aOne pup was missexed on Lactation day 0; data were excluded from the mean number of male and female pups per litter. - 1317 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS (grams): Pi GENERATION Lactation Day 0 Group : VI-0 Dose: 100 m g /k g /d ay Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 8 9 10 11 DuPont-11418 12 13 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 3 5.20 6.30 5.90 6.40 6.70 6.50 6.00 4.80 2 6.40 5.30 5.90 6.30 6.30 5.50 6.60 6.10 4.00 3 8.00 9 7.80 7.30 7.50 6.80 3 7.90 8.20 8.20 8.50 8.40 8.00 7.60 7.305.40 2 8.10 $ 6.50 6.30 7.30 6.90 2 6.40 6.60 6.40 6.10 5.90 6.40 6.40 5.90 3 6.90 7.30 7.60 7.80 7.60 7.70 2 6.80 6.70 7.60 7.50 7.50 6.80 7.10 7.70 3 5.80 6.30 6.30 5.60 6.20 6.00 6.40 6.20 6.10 2 5.30 5.40 5.30 5.30 4.80 5.70 5.40 3 7.00 8.40 7.60 8.00 7.60 7.70 7.90 2 7.30 7.80 7.60 7.90 7.10 7.80 3 8.90 8.00 8.50 9.00 2 8.30 3 8.00 8.10 8.00 8.30 7.20 8.30 2 7.40 7.40 7.50 8.10 7.10 7.40 7.90 3 8.40 7.50 8.00 7.70 9 7.70 7.90 6.00 7.20 7.70 8.30 3 7.30 6.70 7.20 6.90 6.80 6.90 7.30 6.60 9 7.00 6.90 6.70 6.70 3 NP 2 NP 3 6.80 6.70 6.80 6.60 7.40 2 6.50 5.60 6.00 6.30 6.00 6.10 6.30 6.10 6.40 3 8.50 8.50 9.20 8.80 9.00 9 8.20 8.40 3 7.00 8.40 8.00 6.90 7.00 7.90 2 6.70 7.40 7.10 7.70 7.40 7.20 7.00 6.50 3 6.90 7.00 8.40 7.70 7.00 8.40 2 7.40 7.60 7.70 7.40 7.30 3 6.40 6.30 6.30 6.50 6.00 6.70 6.00 6.40 6.90 2 6.10 5.40 6.00 6.30 6.10 5.30 3 8.80 8.40 8.70 7.90 8.60 8.80 7.90 2 7.70 8.10 8.60 6.00 7.80 7.00 7.90 6.90 3 6.10 7.00 6.60 6.70 6.20 6.50 6.60 7.00 6.40 7.10 2 6.20 6.30 6.70 6.20 5.20 3 6.60 5.70 6.00 6.00 6.70 6.20 7.00 6.80 6.60 6.90 2 6.00 5.60 6.00 5.80 7.30 6.40 6.80 - 1318Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS (grams): Fi GENERATION Lactation Day 0 Group: V III-0 Dose: 1000 mg/kg/day Ani mal Pup Number Se x 1 2 3 Pup Number 456789 DuPont-11418 11 665296 7 .20 6 .30 7 .00 6 .50 6.50 7.00 6.50 9 6 .10 6 .70 6 .80 6 .70 6.70 6.70 665193 3 7 .10 5 .60 6 .80 5 .20 7.10 5.40 6.10 6.90 o LO 9 5 .30 6 .40 4 7 .10 6.20 7.00 6.20 665320 3 3 .50 5 .50 5 .90 6 .40 6.10 6.70 5.80 6.00 9 5 .70 5 .70 4 .90 5 .80 5.50 5.40 5.70 665315 3 6 .60 6 .40 6 .40 6 .30 6.50 9 6 .20 6 .60 6 .40 5 .60 6.20 6.70 665318 3 6 .80 7 .40 6 .60 6 .10 7.00 6.30 6.90 7.20 6.80 6.60 9 5 .80 6 .50 5 .60 6 .20 6.50 6.40 6.50 6.20 665279 3 6 .70 7 .20 6 .70 6 .70 6.90 6.10 6.00 9 6 .50 6 .50 6 .30 6 .30 6.10 6.50 5.20 6.40 6.70 6.50 6 6 5 2 2 4 3 -NP 9 NP 665254 3 8 .00 7 .80 8 .00 7 .60 7.30 9 7 .30 7 .60 7 .00 7 .20 7.20 7.30 5.00 7.60 6.80 6.10 665245 3 7 .50 7 .50 7 .70 7 .90 8.60 8.00 8.20 7.70 9 7 .60 8 .00 8 .20 7 .00 665322 3 6 .70 7 .50 7 .00 7 .20 6.40 7.40 7.20 7.30 9 6 .40 6 .80 6 .30 665214 6 6 .60 5 .80 6 .60 6 .60 7 .0 0 6.80 6.70 9 6 ,. 5 0 6 . 2 0 6 . 8 0 6 . 70 6 . 3 0 6 . 2 0 6 6 5 3 2 1 3 6 ,. 5 0 6 . 7 0 5,. 1 0 6 .70 6 . 3 0 6 . 6 0 6 . 5 0 6 . 9 0 6 . 4 0 9 6 . 40 5..60 6 . 1 0 6 . 30 5 . 8 0 6 . 2 0 6 6 5 1 7 1 3 8 .. 50 9,. 4 0 7.. 6 0 9 8 . 30 8 .30 8 . 50 6 6 5 2 6 5 3 8 . 1 0 7..80 7 ,. 30 6 ..40 7 . 3 0 5 . 0 0 8 . 0 0 5 . 9 0 7 . 8 0 9 7 .. 20 7 . 60 7 .. 00 7. 20 7 . 5 0 5 . 6 0 7 . 0 0 6 6 5 1 6 9 3 6 ..30 6 ..80 6 ., 20 6 . 80 5 . 5 0 6 . 5 0 9 5. 80 6 . 20 6 . 00 5. 90 5 .1 0 6 .5 0 6 .6 0 6 .5 0 6.00 6 6 5 1 9 1 3 6 . 60 6 ..30 6 . 20 5. 60 6 . 3 0 6 . 3 0 6 . 8 0 6 . 1 0 6 . 6 0 6 . 6 0 9 5. 90 6 . 00 5. 80 5. 50 665231 3 6 . 50 5. 80 6 . 70 6 . 60 6 . 2 0 7 . 0 0 6 . 8 0 9 6 . 60 5. 80 6 . 10 6 . 30 6 . 3 0 6 . 5 0 5 . 8 0 665255 3 6 . 90 6 . 20 6 . 50 6 . 90 6 . 2 0 6 . 3 0 6 . 6 0 6 . 8 0 6 . 7 0 7 . 3 0 9 5 . 90 4 . 20 5 . 80 6 . 00 6.10 6.00 665213 3 7. 00 6 . 40 6 . 30 6 . 30 6 . 5 0 6 . 0 0 6 . 3 0 9 5. 80 5. 30 5 . 60 5 . 30 6 . 3 0 5 . 6 0 6 . 0 0 6 . 4 0 5 .7 0 665280 3 7 . 30 7. 00 6 . 90 7 . 40 7 . 4 0 7 .1 0 7 .4 0 9 6 . 10 7. 20 6 . 70 6 . 70 6 . 8 0 6 . 2 0 6 . 6 0 5 . 9 0 6 . 4 0 .40 -1319Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP WEIGHTS {grams): Fi GENERATION Lactation Day 4 Preculling Group : I I -0 Dose : 0 mg/k g /d a y Pu d N u mb e r Animal Pup Number Sex 1 2 3 4 5 6 7 8 9 10 665220 665334 ' 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 3 10.5 10.3 10.8 9.80 10.6 11.1 10.0 9 9.60 9.30 9.90 10.1 8.70 9.40 10.2 10.2 3 10.9 12.0 11.1 12.7 12.4 12.1 11.4 11.8 9 11.7 11.6 10.7 11.0 10.3 11.0 3 16.2 15.6 9 15.3 14.7 15.2 15.2 10.9 12.4 10.6 11.6 11.3 11.3 11.5 11.4 9 11.5 11.7 11.2 11.5 3 11.5 10.9 11.0 10.5 11.8 12.1 10.0 11.1 9 11.7 10.6 6.70 9.40 10.9 11.3 10.2 3 11.2 11.6 11.9 11.4 9 10.7 10.6 9.40 10.6 9.80 10.7 9.10 10.8 11.8 3 12.7 13.3 12.8 12.3 11.9 9 12.1 12.4 11.3 9.90 11.9 13.0 12.9 7.20 12.5 13.9 12.5 12.0 12.9 11.8 9 12.3 11.8 11.1 10.5 13.0 10.5 11.8 11.8 11.3 11.2 10.8 9.90 11.6 11.9 12.2 11.9 9 12.2 11.0 10.4 10.6 11.3 NP 9 NP 3 15.5 13.5 15.0 15.5 14.6 14.8 9 12.5 13.4 11.1 13.3 3 13.3. 12.5 12.0 11.5 9.90 11.8 9 11.2 11.2 11.6 12.3 11.0 11.3 11.4 3 11.4 11.2 11.3 10.5 11.5 12.4 9 11.3 12.2 10.2 10.9 10.6 10.8 9.50 9.80 10.2 9.20 3 9.30 10.9 11.3 10.4 9.40 10.4 10.2 12.0 9 8.90 10.5 10.2 11.5 9.00 10.6 10.0 3 13.1 12.4 13.2 12.8 11.3 12.8 12.1 12.3 11.9 12.2 9 10.2 13.0 12.3 3 9.70 8.00 10.9 9.90 9.70 9.90 11.2 9.80 9.60 8.80 9 9.50 9.70 8.70 9.60 9.20 9.70 3 9.80 9.90 7.80 9.20 9.10 7.80 8.00 8.70 9 9.00 8.80 8.40 8.60 8.10 8.40 7.90 3 10.9 10.8 11.9 11.1 9.80 10.3 9 9.40 10.4 8.70 11.3 10.0 10.7 10.2 10.0 3 11.5 9.40 10.9 11.7 11.5 9 10.0 11.1 11.0 11.0 11.1 10.7 10.8 10.8 3 11.7 11.3 11.2 9 10.3 9.10 9.70 10.5 10.2 10.6 10.8 11.4 10.2 9.80 - 1320Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ DuPont-11418 INDIVIDUAL PUP WEIGHTS (grams): Fi GENERATION Lactation Day 4 Preculling Group: IV-0 Dose: 10 mg/kg/day Pup Number A n i m a l Pup^ -------------------- Number Sex 1 2 3 4 5 6 . 7 8 9 10 11 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 6 11.5 13.2 12.1 11.6 11.4 11.6 10.6 2 12.1 11.6 10.5 9.80 S 11.2 10.4 11.2 10.9 11.4 12.6 12.0 2 10.6 10.8 10.4 11.1 a 17.3 16.0 2 16.8 a 9.80 10.4 10.9 11.0 10.3 11.3 2 10.4 9.80 10.5 10.3 10.7 11.0 9.70 a 13.6 12.3 12.2 12.8 2 12.8 12.0 11.2 11.9 10.9 12.7 8.20 10.9 12.0 13.3 13.2 12.7 2 10.7 12.3 11.1 11.9 11.6 10.9 10.0 6 10.9 10.1 10.7 10.0 11.0 10.2 2 10.0 10.3 9.60 11.0 10.5 8.50 a 10.2 11.4 11.4 11.3 11.0 11.8 11.2 2 10.3 9.80 10.3 10.1 a No L i v e Pups 2 No L i v e Pups a 13.1 12.9 2 12.2 12.7 12.3 12.9 12.5 12.5 13.1 a 13.8 13.4 13.2 13.1 13.9 2 13.0 12.7 13.1 12.5 13.7 13.4 11.4 a 11.2 10.5 11.1 11.0 10.7 10.8 11.0 2 10.9 10.4 9.90 9.60 10.0 9.30 d 15.2 13.8 15.4 15.9 2 15.7 14.2 15.0 14.6 13.5 d 11.7 12.5 11.2 12.1 11.5 9.40 10.8 2 12.0 10.3 10.2 10.7 10.7 11.0 9.80 a 12.9 12.6 12.0 13.9 13.1 2 12.5 12.9 12.3 12.7 12.2 12.4 12.4 5 13.2 13.3 13.6 13.4 13.1 2 13.1 11.3 13.6 12.5 12.6 13.0 12.6 a 12.1 12.6 9.50 12.3 10.3 9.50 2 10.4 10.2 9.90 10.4 11.2 10.2 10.0 5 1 4 . 8 1 3 . 4 7 . 6 0 9 . 2 0 13'. 8 1 0 . 5 1 3 . 2 2 11.9 10.7 10.5 6 14.9 14.4 15.1 2 14.2 15.0 14.0 14.5 6 13.4 12.8 13.3 14.0 7.00 13.8 2 11.3 13.0 12.7 13.1 12.6 12.5 12.1 10.1 11.1 11.8 12.4 10.5 10.7 12.7 12.7 13.8 12.0 11.4 9.80 10.3 12.8 13.5 12.8 15.0 12.40 13.00 - 1321 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP WEIGHTS (grams): Fi GENERATION Lactation Day 4 Preculling Group: VI-0 Dose: 100 mg/kg/day Pup Number Animal Pup Number Sex 1 2 3 i4 1 6 7 13 9 1 0 11 12 13 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 8 8 . 60 8 . 3 0 10 . 0 7 . : 10 9 . : 90 10 . 0 9 . 1 0 9 . 150 ? 9 . 30 8 . 1 0 8.130 6 . *40 8 .:20 9.150 9 . 5 0 9 . : 10 8 . 2 0 8 15 .6 ? 16 .4 16. 0 15 . 0 16 .6 8 12 .7 13. 6 11 .9 11 . 9 8 .:30 13 .4 1 3 . 1 13 .3 13 . 1 9 11 .8 i 11 .5 1 0 . 8 11 .0 11 .2 9 10 .4 1 1 . 4 9 . '70 10 .4 10 .5 10 . 0 1 0 . 7 11 . 1 8 11 . 8 1 1 . 2 12 .3 9. 70 l i .4 11 .4 9 10 .7 1 0 . 7 11 .7 11 .7 10 .6 11 .9 1 1 . 8 10 .8 8 10 . 0 1 0 . 7 10 . 0 9 . 50 9 . 40 8 . 50 1 0 . 6 9 . 90 9 . 10 9 9. 30 8 . 1 0 8 . 60 8 . 80 8 . 80 8 . 60 8 11 .5 1 2 . 6 12 .7 13 .4 12 .9 13 . 2 14. 1 9 12 . 6 1 2 . 8 12 .4 13 .4 12 .5 13 . 6 8 16 .5 16. 2 17 .1 16 .1 9 15 .2 $ 14 . 1 13 . 1 12 .3 14 . 1 14 .3 13 .2 9 12 . 6 13 . 5 13 .3 12 .3 12 .5 13 . 2 1 2 . 9 8 14 .2 14. 7 14 .0 14 .8 9 13 . 8 14. 2 14 . 6 14 .2 11 .2 14 . 1 8 13 .3 1 3 . 2 12 .5 12 .5 12 .5 13 . 0 13 . 2 11 . 8 9 12 . 6 1 2 . 6 11 .3 13 .2 8 NP 9 NP 8 11 .9 1 1 . 2 11 .1 10 .1 10 .5 9 12 .2 1 0 . 7 11 .0 10 .6 11 .2 11 .0 1 0 . 1 10 .5 8 16 . 6 13 . 6 16 . 8 15 .3 13 . 6 9 16 .8 12 . 7 8 11 .7 12 . 6 12 .9 12 .5 11 .4 11 .0 9 11 .7 1 1 . 0 12 .8 12 .9 11 .2 11 .9 1 2 . 6 11 .2 a 11 .8 1 1 . 7 12 .4 11 .1 12 .0 12 .5 9 11 .7 1 1 . 7 11 .8 12 .0 10 .9 a 11 . 1 12 . 4 9. 80 13 . 6 11 .5 11 . 6 10 . 4 11 . 1 10 .9 9 8 . 50 10 . 6 9. 90 10 . 6 11 .5 11 .2 a 13 . 1 13 . 6' 14 . 8 12 .7 13 .3 12 . 0 1 3 . 2 9 13 . 0 1 2 . 0 12 . 6 i o . 8 10 . 2 12 . 2 1 2 . 0 13 . 1 a 9. 20 1 0 . 6 11 .4 11 .5 10 .6 9. 50 1 0 . 4 10 .4 10 .6 1 0 .7 9 9. 50 1 1 . 3 9. 10 8 . 70 7 . 40 a 11 .2 1 2 . 9 10 . 0 10 .6 10 .0 11 .1 1 0 . 8 10 .6 10 .1 1 0 .9 1 1.6 1 1 .5 1 2.5 5 10.6 10.6 10.9 9.60 - 1322 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP WEIGHTS (grams): Fi GENERATION Lactation Day 4 Preculling Group: VIII-0 Animal Pup Number Sex 1 2 3 4 Dose: 1000 mg/kg/day Pup Number 5 6 7 8 9 10 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 d 10.9 10.7 11.5 11.3 10.6 10.2 11.3 2 10.6 10.8 10.2 10.3 11.0 11.5 3 10.8 9.30 10.8 9.40 11.5 12.1 11.5 8.60 ? 10.0 10.5 8.20 10.4 8.80 11.5 10.1 3 9.60 9.40 10.8 10.2 8.90 9.40 9.10 ? 9.30 9.40 8.20 9.00 8.40 8.80 7.90 s 11.1 11.6 10.8 11.6 10.8 9 11.3 10.1 10.4 10.9 11.6 10.3 3 9.10 8.00 9.60 11.3 10.3 10.3 9.40 10.7 10.9 9.90 2 10.7 7.40 8.80 10.2 9.70 9.50 9.20 8.70 3 11.8 11.7 11.0 9.60 12.0 10.5 11.5 2 10.6 10.2 10.8 10.9 9.80 7.70 11.2 10.4 8.10 12.0 3 NP 2 NP 3 12.0 11.1 12.7 12.5 12.2 2 8.20 10.3 12.0 11.2 12.3 10.9 6.60 10.1 11.3 10.7 3 12.2 13.7 12.0 13.3 13.6 13.5 13.0 13.1 2 12.1 13.1 12.6 11.7 13.4 13.1 11.7 11.9 12.2 12.7 12.7 11.9 2 11.2 11.4 12.7 3 12.1 11.8 11.0 10.7 11.5 11.9 11.6 9 10.7 11.7 11.0 10.7 11.7 11.0 d 10.0 9.90 9.70 10.4 10.6 10.8 10.3 11.0 8.50 2 8.90 9.10 9.90 9.40 9.60 8.80 d 17.0 15.0 17.1 2 16.6 16.3 16.0 3 7.80 7.60 7.30 8.90 6.40 9.90 11.3 9.40 2 8.90 10.1 8.70 6.70 9.30 9.00 8.10 d 10.5 11.8 11.0 11.0 10.4 11.6 2 11.1 11.8 9.50 9.90 10.0 8.20 10.3 10.8 11.5 3 10.2 10.2 10.8 10.9 10.3 10.7 10.1 10.5 10.6 10.1 2 10.1 8.00 9.70 9.60 d 11.5 11.9 10.7 10.5 9.70 9.90 10.2 2 10.1 10.5 9.70 10.1 11.1 11.4 11.4 d 10.6 10.2 11.6 10.6 10.3 10.1 11.8 10.2 11.0 10.7 9 2 8.90 10.0 9.00 9.00 10.0 6.50 3 11.0 11.4 9.00 10.6 11.3 10.7 10.2 2 10.2 10.0 9.50 9.50 10.9 9.90 8.40 9.40 9.00 d 12.3 12.5 12.6 12.6 11.7 12.4 11.7 2 11.6 10.9 10.3 11.2 13.0 11.7 11.1 10.2 11.1 - 1323Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F l GENERATION L a c t a t i o n Day 4 P o s t c u l l i n g G r o u p : I I --0 Doss: 0 mg/kg/day Animal Pup Number Sex 1 Pup Number 234 5 665220 665334 665257 665175 665336 665192 665232 665307 665246 3 10 .5 10 .3 10 .8 10 .0 ? 9.:30 8 .'70 9 .. 40 10 . 2 3 12 .0 11 .1 12 .4 12 .1 9 11 .6 10 .7 10 .3 11 .0 3 16 . 2 15 . 6 9 15 .3 14 .7 15 . 2 15 .2 3 12 .4 11 .6 11 .3 11 .5 9 11 .5 11 .7 11 .2 11 .5 3 11 .0 11 .8 12 .1 10 .0 9 6 .'70 9 . 40 10 . 9 1 0 . 2 $ 11 .2 11 .6 11 .9 11 .4 9 10 . 7 9 . 40 9 . 80 9 . 10 3 13 .3 12 . 8 12 .3 11 .9 9 12 .4 11 .3 13 . 0 12 .9 3 13 .9 12 .5 12 . 0 11 .8 9 12 .3 13 . 0 10 .5 11 . 8 <3 11 .3 10 . 8 1 1 . 9 1 1 .9 9 12 .2 11 .0 10 .4 10 .6 6 6 5 2 8 9 3 NP 9 NP 6 6 5 2 6 4 <5 15 .5 15 . 0 14 . 6 14 . 8 9 12 .5 13 .4 11 . 1 13 .3 665185 3 12 .5 12 . 0 9. 90 11 .8 9 11 .2 11 .6 12 .3 11 .0 665206 S 11 .4 11 .2 11 .3 10 .5 9 10 .2 10 .6 10 .8 10 .2 6 6 5 3 0 6 <3 9 . 30 11 .3 9 . 40 10 .4 9 11 .5 9. 00 10 .6 10 .0 665226 6 13 .1 13 .2 12 . 8 11 .9 9 10 .2 13 . 0 12 .3 665198 5 8 . 00 10 .9 9. 70 11 .2 9 9. 70 8 . 70 9. 20 9. 70 6 65 24 9 3 7 . 80 9 . 10 7 . 80 8 . 00 9 9. 00 8 . 80 8 . 60 8 . 40 665284 . 3 10 .9 10 . 8 11 .9 11 .1 9 8 . 70 11 .3 10 . 0 10 .7 6 6 5 2 4 0 (3 11 .5 9 . 40 10 . 9 11 .5 9 11 .0 11 .1 10 .7 10 .8 665203 3 11 .7 11 .3 11 .2 9 10 .5 10 .2 10 .6 10 .8 DuPont-11418 - 1324Company Sanitized. Does not contain TSCA CBI HI-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : GENERATION L a c ta tio n Day 4 P o s t c u l l i n g Group: IV-0 Dose: 10 m g / k g / d a y Animal Pup Number Sex 1 Pup Number 2 3 4 __5 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 3 11.5 11.6 11.4 10.6 9 12.1 11.6 10.5 9.80 3 10.9 11.4 12.0 11.1 $ 10.6 10.8 10.4 11.1 17.3 16.0 9 16.8 3 10.4 10.9 10.3 11.3 9 10.4 10.5 10.7 11.0 3 13.6 12.3 12.2 12.8 9 12.8 12.0 11.2 11.9 <? 1 2 . 7 8 . 2 0 1 2 . 7 1 1 . 8 9 12.3 11.9 11.6 10.0 3 10.9 10.1 10.0 11.0 9 9.60 11.0 10.5 8.50 3 11.4 11.3 11.2 10.7 9 10.3 9.80 10.3 10.1 S No L i v e P u p s 9 No L i v e Pups 3 13.1 12.9 9 12.7 12.3 12.9 12.5 '3 1 3 . 4 1 3 . 2 1 3 . 1 1 3 . 9 9 12.7 12.5 13.7 13.8 S 11.2 10.5 11.1 11.0 9 10.9 10.4 9.90 9.30 S 15.2 13.8 15.4 15.9 9 15.7 14.2 15.0 14.6 3 12.5 11.2 11.5 10.8 9 12.0 10.3 10.7 9.80 3 12.6 12.0 13.9 13.1 9 12.9 12.7 12.4 12.4 3 13.2 13.3 13.6 13.4 9 11.3 13.6 12.5 13.0 3 12.6 12.3 10.3 9.50 9 10.2 10.4 11.2 10.0 3 13.4 9.20 13.2 12.8 9 11.9 10.7 10.5 3 14.9 14.4 15.1 9 14.2 15.0 14.0 14.5 12.8 13.3 14.0 13.8 9 12.7 13.1 12.6 12.5 DuPont-11418 - 1325 Company Sanitized. Does not contain TSCA CBI /""N H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 4 P o s t c u l l i n g Group: VI-0 Dose: 100 m g/kg/day Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 3 8.60 2 8.80 3 15.6 9 16.4 3 12.7 2 11.8 3 11.5 2 10.4 3 11.2 2 10.7 3 10.0 2 9.30 3 11.5 2 12.6 3 16.5 2 15.2 3 13.1 2 12.6 3 14.2 2 13.8 6 12.5 2 12.6 3 NP 9 NP 6 12.2 2 11.2 <3 1 6 . 6 2 16.8 3 11.7 2 11.7 6 11.7 2 11.7 3 9.80 2 9.90 6 13.1 2 12.0 6 9.50 9 9.50 6 12.9 9 10.6 8.30 6.40 16.0 13.6 10.8 11.4 12.3 11.7 10.0 8.10 13.4 12.8 16.2 12.3 13.3 14.7 14.2 12.5 12.6 10.7 11.1 13.6 12.7 12.6 12.8 12.4 11.8 13.6 10.6 14.8 12.6 10.4 9.10 10.0 10.6 9.90 9.50 15.0 11.9 11.0 10.0 9.70 11.9 8.50 8.60 12.9 13.4 17.1 14.1 12.3 14.0 14.6 13.0 11.3 11 .0 10 .1 16 .8 12 .9 12 .9 11 .1 12 .0 11 .5 11 .5 3 .3 10 .2 10 .6 8 . 70 10 .6 10 .9 9. 10 8 . 20 16 .6 8 . 30 11 .2 11 .1 11 .4 11 .8 9. 90 8 . 60 13 . 2 12 .5 16 .1 14 .3 13 .2 14 .8 14 .2 11 .8 13 . 2 10 .6 10 .5 15 .3 11 .4 11 .9 12 .5 10 .9 10 .9 11 .2 12 .0 12 .2 10 .7 7. 40 11 .5 9. 60 13.4 13.1 13.6 13.3 DuPont-11418 - 1326Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c ta tio n Day 4 P o s t c u l l i n g Group: V III-0 Animal Pup Number Sex 1 Dose: 1000 m g/kg/day Pup Number 2345 665296 9 665193 S 2 665320 $ 9 6 6 5 3 1 5 <? 2 665318 S 2 665279 3 2 665224 3 2 665254 3 2 665245 3 2 665322 3 2 665214 3 2 665321 3 2 665171 3 2 665265 3 2 665169 3 2 665191 3 2 665231 3 2 665255 , 3 2 665213 2 665280 3 2 10.7 11.5 10. 8 . 10.3 10.8 9.40 10.0 10.5 9.40 9.30 11.1 10.1 10.2 9.40 11.6 10.4 8.00 11.3 7.40 9.50 11.8 11.0 10.8 10.9 NP NP 12.0 11.1 12.0 10.9 12.0 13.6 12.1 13.1 13.1 11.7 11.2 11.4 12.1 11.8 11.7 11.0 9.70 10.4 8.90 9.10 17.0 15.0 16.6 16.3 7.30 8.90 10.1 6.70 11.8 11.0 11.8 9.90 10.2 10.3 10.1 8.00 11.9 10.5 9.70 10.1 10.6 10.6 9.00 9.00 9.00 10.6 10.2 10.0 12.5 12.6 11.6 10.9 11.3 11.0 11.5 8.20 8.90 8.40 10.8 11.6 10.3 9.20 9.60 11.2 12.7 10.1 13.0 12.6 12.2 12.7 11.0 10.7 10.3 9.90 17.1 16.0 6.40 9.00 10.4 8.20 10.1 9.70 9.70 11.1 10.3 10.0 11.3 9.40 12.6 10.3 10.6 11.5 8.60 11.5 9.40 8.80 11.6 10.3 10.9 8.70 12.0 12.0 12.2 11.3 13.1 11.7 12.7 11.5 11.0 11.0 9.40 11.3 8.10 11.6 10.8 10.5 9.60 10.2 11.4 11.0 6.50 10.7 9.00 12.4 11.1 11.9 DuPont-11418 - 1327 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c ta tio n Day 7 Group: II-O Dose: 0 mg/kg/day Animal Pup Number Sex 1 Pup Number 234 5 665220 3 ? 665334 3 9 665257 3 9 665175 3 9 665336 3 9 665192 6 9 665232 3 9 665307 3 9 665246 3 9 665289 3 9 665264 3 9 665185 3 9 665206 3 9 665306 3 9 665226 3 9 665198 3 9 665249 3 9 665284 . 3 9 6 6 5 2 4 0 <3 9 665203 3 9 17.9 16.3 21.0 18.3 24.0 24.0 19.2 17.2 17.4 18.8 17.0 15.8 22.2 20.5 23.1 20.5 18.5 17.3 NP NP 22.3 22.5 21.1 18.7 19.3 17.6 19.9 18.5 20.8 17.4 17.2 16.5 15.2 14.0 17.1 16.2 15.1 17.2 17.3 15.8 16.4 14.9 19.3 17.6 24.4 22.7 17.8 18.1 20.7 19.0 17.3 17.0 21.3 22.3 21.1 20.5 19.0 17.0 23.9 22.0 16.0 19.6 19.2 18.7 15.9 17.4 20.8 19.9 16.1 16.4 12.5 14.5 17.4 17.6 18.9 17.9 18.3 16.7 17.1 16.1 20.5 18.9 17.2 17.1 18.5 17.5 23.9 17.6 17.8 19.9 11.4 17.0 14.4 20.6 21.9 21.5 19.0 17.8 19.1 23.3 17.8 17.8 19.5 17.3 18.1 14.2 19.9 19.7 20.7 21.4 17.6 17.5 23.2 23.6 23.9 19.2 20.2 19.7 18.7 19.5 19.1 16.3 17.2 16.4 18.3 17.9 16.3 20.9 21.2 20.8 18.1 17.2 17.1 15.0 13.4 13.3 15.3 15.2 17.3 '19.1 14.2 15.3 18.8 17.3 17.2 17.7 17.3 16.1 17.0 21.20 DuPont-11418 - 1328 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________ _ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F l GENERATION L a c ta tio n Day 7 Group: IV -0 Animal Pup Number Sex 1 Dose: 10 m g / k g / d a y Pup Number 2 .3 4 56 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 3 18.5 17.6 18.0 18.7 9 19.3 16.4 17.5 17.5 3 19.2 18.8 18.7 20.0 9 18.9 17.9 18.1 17.9 C? 2 2 . 9 2 5 . 4 2 24.3 3 17.8 17.6 18.5 18.2 2 18.0 18.1 17.1 18.3 3 18.0 17.6 18.2 19.5 2 18.5 16.1 17.4 17.0 3 21.1 21.8 14.2 20.6 2 17.8 20.6 19.9 19.3 3 16.4 15.1 15.5 16.5 2 16.6 15.5 14.3 13.3 3 19.1 19.4 17.5 18.9 2 16.1 17.8 17.2 16.7 3 No L i v e :Pu p s 2 No L i v e :Pu p s 3 21.5 21.3 2 20.4 20.3 21.3 20.5 3 22.1 21.4 21.5 21.6 9 21.8 20.6 20.5 22.8 3 17 .3 1 7 .1 1 8 .1 1 7 .2 2 15.5 17.9 16.4 17.0 3 21.2 22.4 23.6 21.6 2 21.7 21.8 21.0 21.5 3 18.6 17.7 19.3 18.4 2 18.1 17.6 17.0 17.2 3 18.1 20.9 19.8 18.9 2 18.8 19.0 17.8 18.7 3 20.9 21.1 21.2 20.3 2 20.7 20.7 18.6 20.2 3 18.8 20.0 19.4 16.9 2 17.9 16.3 15.4 17.2 3 23.3 17.0 21.9 16.4 2 19.6 18.3 18.6 d 21.5 22.1 22.6 2 22.1 21.4 21.4 20.8 d 21.6 21.8 21.8 19.6 2 20.0 20.0 19.3 19.9 DuPont-11418 - 1329Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION /***m ' L a c t a t i o n Day 7 Group: VI-0 Dose: 100 m g/kg/day Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 <5 1 5 . 3 ? 9.00 <1 2 3 . 7 9 24.1 3 21.4 9 18.6 18.6 9 16.4 3 20.1 9 19.3 3 15.1 9 16.7 d 21.7 9 19.7 3 25.3 9 24.6 3 23.4 9 21.2 3 21.6 9 20.8 8 19.4 9 20.2 <5 NP 9 NP 8 21.0 9 17.2 3 23.5 9 17.1 <3 2 1 . 0 9 20.0 8 17.3 9 18.4 3 19.7 9 18.7 8 21.6 9 20.4 3 18.4 9 16.4 3 17.5 9 16.6 16.4 13.9 22.2 19.7 17.2 16.5 16.8 18.3 17.6 14.4 18.7 20.3 25.8 20.5 22.5 21.5 20.0 20.9 19.7 19.3 18.1 21.5 21.5 18.7 20.1 18.6 18.2 21.4 16.7 22.1 16.5 16.9 12.6 18.8 17.3 14.3 10.8 23.3 21.6 17.4 17.3 19.8 19.8 17.3 14.3 21.2 21.7 26.1 24.0 21.2 21.4 20.9 20.8 18.8 19.5 18.6 19.8 18.9 20.5 19.3 17.4 19.8 17.7 20.6 19.8 17.9 17.0 17.2 18.0 14.8 14.8 24.2 20.0 18.1 18.4 16.8 19.1 17.1 14.9 19.9 20.2 24.8 22.1 21.4 21.1 20.9 19.4 21.2 18.1 23.5 20.8 20.7 18.3 18.5 16.6 16.4 23.0 20.9 17.2 15.1 20.4 18.0 20.2 17.9 20.5 20.7 15.9 - 1330Company Sanitized. Does not contain TSCA CBi H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c ta tio n Day 7 Group: V III-0 Dose: 1000 mg/kg/day Animal Pup Number Sex 1 Pup Number - 23 4 5 665296 3 ? 665193 3 5 665320 9 665315 3 9 665318 3 9 665279 3 9 665224 3 9 665254 3 9 665245 3 9 665322 3 9 665214 3 9 665321 3 9 665171 3 9 665265 3 9 665169 3 9 665191 3 9 665231 3 9 665255 . 3 9 665213 3 9 665280 3 9 18.0 17.4 16.8 18.2 16.3 15.2 17.0 17.4 14.8 15.4 15.2 14.5 17.4 18.5 17.4 16.5 16.8 18.2 14.8 14.3 21.1 16.5 19.0 18.3 NP NP 20.2 22.2 21.3 17.0 21.3 18.6 18.4 19.5 19.7 18.7 18.6 19.0 18.3 18.5 18.6 18.0 16.1 17.1 15.3 16.0 24.6 22.6 22.7 23.4 9.60 14.5 12.0 12.8 17.5 18.6 13.9 18.2 16.6 16.2 16.4 16.6 18.0 17.9 16.2 15.9 17.1' 18.0 16.5 16.2 17.8 17.8 17.2 16.8 20.8 18.9 18.5 17.9 17.6 18.3 18.0 13.8 16.5 14.9 18.9 19.7 17.5 14.8 20.5 19.0 21.2 19.3 21.0 20.8 20.3 17.8 19.4 18.8 16.7 14.9 24.8 23.0 9.80 14.2 19.8 16.8 16.9 16.3 16.0 16.1 18.5 15.6 17.9 14.4 21.0 19.1 17.9 18.0 19.2 18.8 15.3 13.6 18.7 17.3 12.6 12.8 19.5 20.0 19.2 19.0 20.7 19.5 18.4 18.1 17.1 17.2 15.2 15.8 10.0 19.6 19.8 15.7 14.4 17.0 15.7 18.3 11.5 18.3 15.0 19.9 17.1 19.5 DuPont-11418 - 1331 Company Sanitized. Does not contain TSCA CBI Z"**'' H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 14 Group: II-O Dose: 0 mg/kg/day Animal Pup Number Sex 1 Pup Number ` 234 5 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 3 35.6 36.8 35.9 35.1 9 34.6 35.0 35.6 32.6 3 41.0 38.6 38.5 42.2 9 37.0 37.2 38.7 36.6 3 49.6 47.9 9 47.9 47.8 48.6 46.3 3 36.8 35.4 34.8 35.5 9 35.5 35.7 35.5 34.7 3 35.9 39.0 37.8 38.9 9 36.8 22.9 34.9 37.9 3 36.8 35.9 33.9 32.7 9 32.2 35.9 32.0 34.6 3 42.8 41.0 41.2 42.6 9 43.0 38.3 40.0 42.3 3 41.0 41.6 43.0 40.8 9 41.1 42.0 40.1 38.4 3 32.8 33.2 32.5 33.6 9 32.2 32.8 31.7 31.4 3 NP 9 NP 3 45.3 44.1 46.8 43.6 9 38.6 42.9 37.8 43.1 3 42.7 43.3 43.8 39.3 9 41.8 42.4 40.2 3 38.5 39.7 37.8 38.6 9 35.5 35.0 38.6 36.4 3 39.1 36.5 37.0 35.5 9 34.4 38.8 37.9 37.5 3 42.9 40.3 41.1 41.1 40.50 9 41.7 40.1 36.8 3 36.1 40.2 37.9 37.9 9 37.3 35.4 37.2 35.9 3 35.4 35.6 33.0 32.8 9 35.8 33.6 35.3 35.6 3 35.6 35.2 38.8 35.4 9 34.5 37.2 34.7 31.1 3 37.4 39.6 39.5 31.5 9 36.9 37.0 36.2 38.0 6 34.9 35.7 34.8 9 34.8 34.5 33.3 34.5 34.00 DuPont-11418 - 1332 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 14 Group: IV-0 Animal Pup Number Sex 1 Dose: 10 m g/k g /d a y Pup Number 2345 6 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 3 36.0 36.3 37.0 36.0 9 3 3 . 9 3 7 . 5 3 3 . 5 3*5.1 3 41.1 39.7 40.7 39.0 ? 39.7 38.2 40.6 39.3 3 49.0 42.6 9 41.2 3 36.5 36.4 36.4 37.9 2 37.0 36.8 36.6 35.5 3 35.4 35.3 38.3 34.6 2 32.7 34.8 34.9 36.8 3 41.2 39.8 40.2 31.4 2 37.2 39.8 37.7 40.4 32.0 31.8 32.6 32.6 2 29.8 31.3 28.3 32.0 38.2 35.5 37.8 38.9 2 37.6 34.1 38.0 34.3 No L i v e P u p s 2 No L i v e P u p s 42.3 42.0 2 42.2 42.2 38.3 39.8 45.2 43.0 42.8 43.3 2 43.6 42.5 44.4 41.2 36.4 37.1 34.9 36.4 2 38.0 37.5 36.5 35.3 43.3 41.7 40.4 42.6 2 41.7 42.3 39.8 40.3 3 37.6 35.8 36.5 37.0 2 36.3 34.5 35.3 35.0 3 37.9 35.1 38.9 40.5 2 36.8 36.8 36.9 36.0 3 38.8 40.7 39.9 39.3 2 37.8 37.0 38.6 38.4 3 41.4 37.5 39.3 39.0 2 37.1 37.2 35.2 35.0 3 4 2 .2 3 7 .9 42 . r 3 8 .0 2' 38.0 39.9 39.1 3 40.2 40.9 41.6 2 39.2 38.3 39.7 39.2 3 41.2 39.0 36.4 38.9 2 38.6 37.4 38.0 37.9 .2 4 0 .8 DuPont-11418 - 1333 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 14 Group : VI- 0 Dose: 100 mg/lcg/day Pup Number Animal Pup Number Sex 1 2 3 4 5 6 7 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 3 33.2 34.4 34.6 33.0 9 32.9 27.4 34.3 3 45.3 9 44.7 41.9 44.4 43.0 3 42.7 43.8 49.9 42.4 42.8 32.7 42.8 9 41.4 3 37.2 37.1 36.8 36.0 9 34.0 36.7 35.1 34.6 3 39.3 41.2 36.6 35.5 9 37.9 38.8 39.0 38.5 3 38.2 38.9 35.5 38.7 9 35.3 34.1 34.7 33.2 3 37.6 40.9 39.1 37.3 9 37.2 37.6 39.3 39.0 3 48.2 49.0 48.9 47.7 9 47.8 3 44.4 40.5 42.2 46.7 9 41.5 43.6 43.9 42.2 3 39.5 39.6 40.1 38.4 9 39.1 39.9 39.9 38.4 3 40.7 40.1 41.5 40.9 9 40.9 41.2 41.3 40.4 3 NP "" 9 NP 3 40.9 38.5 38.9 9 34.9 37.3 36.5 36.5 38.6 S 35.9 33.3 32.7 35.8 32.7 9 30.4 32.4 3 38.3 41.0 41.2 40.7 9 41.1 39.5 42.1 39.0 3 34.5 37.5 37.7 38.1 9 37.7 37.3 36.4 36.7 3 38.5 42.6 38.2 40.9 9 37.4 39.8 39.6 35.7 s' 4 6 . 3 4 5 . 5 4 6 . 1 4 3 . 8 9 43.9 37.9 41.1 42.3 3 36.3 36.7 37.3 36.9 9 35.6 28.5 35.6 34.4 3 41.6 38.4 40.7 38.2 9 38.2 37.2 37.6 37.6 DuPont-11418 - 1334 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F l GENERATION L a c t a t i o n Day 14 Group: V III-0 Dose: 1000 mg/kg/day Animal Pup Number Sex 1 Pup Number -- 2345 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 3 38..3 35..8 35..3 36..9 2 38..1 36..3 34..2 36..7 3 39.,0 41..6 33.,8 36.,6 2 38.,8 32.,9 39..6 40..3 d 31.,8 32.,7 33 . 7 32..5 2 31.,6 31.,5 31..1 30..4 3 37..6 36..5 36..1 35..9 2 35..4 38.,6 34..5 33..5 3 37 ,. 0 3 8 . .4 3 8. .7 30 . .9 2 32..9 35.,1 30.,8 33..4 3 42,.6 39.,2 42..6 42 .9 2 39..3 40..2 39.,6 41..2 3 NP 2 NP 3 40,.7 44..0 39,.0 43,.4 2 39,.3 41..4 41 .3 39 .7 d 41,.7 41 . .0 39 ,.4 40,.5 2 39,.5 36..9 39,.7 40..7 d 38,.6 38..4 38..6 40,.4 3 7 .6 2 37,.7 35..3 38,.0 d 37 .4 36..6 38..4 38..6 2 37 .5 36,.1 36,. 0 38 .3 d 35 .9 34,.6 33,.4 35 .3 2 33,.1 32..8 33 .2 32,.3 d 44,.9 47,.7 47,.0 2 45 .6 43..7 44 .5 d 27 .4 36,.7 25 .9 32 .6 2 29 .3 33 . 2 25 .3 27 .9 d 40 .9 39 ,.9 39 .9 37 .3 2 38 .6 30,.6 35 .6 39 .5 d 34,.4 33 ,. 8 34 .9 34 .5 2 33,.6 31,.4 34 .0 33 .7 d 38,.3 35 ,. 8 37 .9 38 .3 2 36,. 2 37 ,.4 37 . 8 36 . 0 d 36,.3 38,.2 38 .2 38 .7 ' 2 29,.9 34..8 36 .5 36 .4 d 40,.2 38,.6 39 .5 39 .1 2 36..6 38..3 37 .5 36 .9 d 41..3 39,.7 42 .3 42 .4 2 37,.5 39,.6 39 .5 38 .9 DuPont-11418 - 1335 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F l GENERATION L a c t a t i o n Day 21 Group: II-O Vnimal Pup Slumber S e x 1 Dose: 0 mg/kg/day Pup Number 234 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 3 53. 8 55. 5 56. 5 54. 8 9 53. 5 54.,2 53.,4 50. 0 3 6 4 . 3 69.,4 72 ., 0 64., 1 9 62. 2 60..5 61..7 59..8 6 79. 8 78..4 9 78. 6 79..5 76..1 74.,8 3 62. 4 57..7 56..5 53..7 9 58. 7 55..4 58..1 56..2 3 61. 3 64..0 63 . 1 58..3 9 26. 7 58..7 55..1 60..1 3 50. 2 56..8 56..4 53..3 9 5 3 . 9 48,.3 52 ,. 6 52..9 3 6 8 . 2 64,.3 69,.4 6 8 .4 9 6 8 . 1 63 .2 69 . 1 65,.8 3 65. 8 64..3 64..6 61..0 9 59. 8 62,.5 58..4 64,.6 3 58. 5 56 .5 59,. 0 55,.5 9 5 6 . 6 54 .4 52 ,.4 53 . 5 3 NP 9 NP 3 7 4 . 4 79 . 0 72 ,.9 75.. 6 9 74. 6 61 .5 65 .7 70 .7 3 64. 4 59 .3 65 .2 65..0 9 61. 1 61 .7 58 .0 J 61. 0 63 . 6 61,.3 59,. 6 9 58. 2 56 .7 53 . 1 58,.9 3 57 . 4 63 . 6 56 .2 60 .0 9 58. 4 60 .2 54 .0 55..8 3 67 . 0 61 .4 63 .3 64 .5 9 63. 6 64,.7 56,.8 3 62. 4 56,.4 65..7 62,.4 9 58. 3 58,.6 58,.9 56,.6 6 54. 0 52 .6 55..4 53..6 9 55. 7 53 .9 55..3 53,.2 3 62' 0 50,.7 55 .5 49,.6 9 47 . 9 57,.4 55..6 52..5 65. 2 61..3 64..3 50..6 9 60. 3 61..5 58,.6 62..3 <? 5 6 . 7 57.. 2 59..3 9 54. 3 58,.7 54..0 58,.1 DuPont-11418 - 1336Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 21 Group: IV-0 Dose: 10 m g /k g /d a y Animal Pup Number Sex 1 Pup Number 234 5 6 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 3 58.3 64.5 62.3 9 59.0 55.9 59.1 s 68.7 62.6 60.1 9 63.5 60.3 60.8 3 79.2 68.3 9 61.3 3 60.2 59.1 59.3 9 60.5 57.9 61.5 3 57.9 55.8 57.1 9 59.3 55.6 54.3 3 64.9 68.6 67.9 9 66.5 68.5 59.6 3 55.0 56.4 54.0 9 53.0 54.5 48.9 3 64.3 61.5 61.3 9 56.6 62.3 60.4 3 No L i v e P u p s 9 No L i v e Pu ps 3 68.1 66.4 9 65.5 65.2 66.2 3 70.0 73.5 67.6 9 63.6 70.3 65.4 3 63.5 60.0 55.5 9 60.7 59.3 55.4 3 75.3 68.7 69.0 9 70.8 66.9 68.6 3 61.3 63.6 63.5 9 57.8 60.4 54.3 S 65.4 61.9 57.8 9 57.2 58.5 58.1 3 . 68.3 65.9 67.6 9 63.8 61.4 62.9 3 59.5 63.3 65.1 9 56.6 62.8 61.7 3 73.4 64.7 71.3 9 65.6 62.9 65.4 3 68.5 72.0 66.9 9 65.8 63.4 61.6 S 66.4 67.1 63.7 9 62.3 63.8 61.3 61.6 64.4 65.4 56.0 57.6 58.4 59.9 53.5 45.3 62.1 56.3 50.2 60.2 57.6 66.4 70.1 67.6 58.3 59.8 68.1 66.1 56.9 59.8 65.4 59.4 69.2 65.6 61.2 54.5 72.1 61.2 62.7 63.6 63.1 DuPont-11418 - 1337 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 21 Group: VI-0 Dose: 100 m g/kg/day pup Number Animal Pup Number Sex l 2 3 4 5 67 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 56.3 57.9 58.2 54.6 9 53.1 53.7 45.5 76.5 67.4 68.3 68.1 9 72.3 $ 55.4 72.7 75.0 71.4 69.7 74.6 69.9 9 67.1 a 60.4 58.7 61.0 58.2 9 55.8 52.7 55.2 57.0 65.2 56.0 61.8 63.5 9 61.2 59.2 64.1 61.2 a 66.4 68.2 61.4 63.2 9 60.0 58.7 56.8 55.9 a 63.0 69.4 61.8 66.8 9 62.8 63.3 66.9 62.3 a 78.1 80.4 80.9 76.5 9 73.1 a 68.3 70.1 62.3 74.0 9 66.0 61.5 63.3 64.3 a 63.6 67.7 64.2 64.0 9 66.2 61.8 65.7 60.6 a 61.6 67.9 64.7 62.6 9 63.2 66.3 60.8 65.5 a NP 9 NP a 67.4 66.9 61.1 9 60.9 60.2 58.7 56.5 58.7 a 63.2 67.1 61.4 60.6 66.9 9 63.2 56.1 a 67.2 62.9 66.7 64.1 9 62.5 68.4 60.9 61.9 a 61.4 60.1 56.1 54.3 9 60.7 58.0 57.7 55.2 a 60.9 63.5 64.2 67.3 9 62.1 57.4 59.8 60.6 a 71.5 74.1 79.4 76.0 9 63.4 68.7 73.2 67.7 a 57.2 57.7 59.2 59.6 9 56.2 57.2 41.6 51.3 a 69.5 61.4 61.1 67.0 9 59.6 64.5 61.1 60.6 DuPont-11418 - 1338 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ________ INDIVIDUAL PUP WEIGHTS ( g r a m s ) : F i GENERATION L a c t a t i o n Day 21 Group: V III-0 Dose: 1000 m g/kg/day Animal Pup Number Sex 1 Pup Number -- 234 5 665295 5 60.0 9 59.3 6 6 5 1 9 3 <5 6 7 . 7 9 61.6 6 6 5 3 2 0 <3 5 2 . 9 9 50.8 665315 8 62.2 9 62.0 6 6 5 3 1 8 <3 5 0 . 7 9 56.5 6 6 5 2 7 9 <3 6 9 . 4 9 62.6 6 6 5 2 2 4 <3 NP 665254 9 NP <3 7 5 . 2 9 67.8 665245 665322 <3 6 7 . 3 9 64.1 <3 6 1 . 6 9 61.7 6 6 5 2 1 4 <3 5 5 . 0 9 55.1 6 6 5 3 2 1 <3 6 3 . 2 9 57.6 6 6 5 1 7 1 c3 7 8 . 1 9 73.2 6 6 5 2 6 5 c3 4 4 . 5 9 46.2 6 6 5 1 6 9 <3 6 1 . 5 9 49.3 6 6 5 1 9 1 <3 6 0 . 5 9 57.9 6 6 5 2 3 1 <3 6 4 . 1 9 63.0 665255 . 3 65.6 9 48.1 6 6 5 2 1 3 <3 6 3 . 4 9 57.7 6 6 5 2 8 0 c3 7 2 . 4 9 64.6 61.3 57.4 54.3 51.4 53.4 48.7 60.5 55.5 6 6 .1 55.0 62.2 64.1 77.1 6 8 .1 6 8 .2 65.8 66.7 63.7 58.3 54.1 60.3 53.2 81.4 67.0 47.9 51.8 60.4 55.2 60.0 56.4 57.3 58.2 60.5 59.8 61.2 57.3 68.4 62.7 63.0 54.3 63.1 63.8 55.7 51.7 61.9 65.4 58.3 49.0 6 6 .1 62.1 70.2 69.2 6 6 .1 66.7 63.8 58.8 57.2 54.1 59.1 55.2 71.1 68.9 53.6 45.8 65.6 61.6 60.8 51.7 62.4 56.1 60.1 58.3 62.2 57.9 6 8 .6 58.3 59.3 58.8 58.9 60.3 52.3 51.9 66.7 55.9 59.0 52.5 70.0 64.3 73.0 69.3 6 8 .2 58.8 65.6 56.4 55.6 58.4 52.9 59.8 56.3 58.7 61.2 58.5 56.8 61.2 57.9 63.3 58.8 65.9 57.4 63.7 64.3 61.4 DuPont-11418 - 1339 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX JJ INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN Fi MALE AND FEMALE RATS - 1340 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 9Q-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN F, MALE AND FEMALE RATS EXPLANATORY NOTES Note Test Day 1 = Postnatal Day 21 Abbreviation NR = Not recovered; the given sign was observed on the date that the animal died. - 1341 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN F1A MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 20 20 20 19 19 22 22 25 25 23 23 20 20 40 40 NR 40 40 NR 23 23 21 21 22 22 36 40 NR 20 20 23 23 21 21 - 1342 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN PIA MALE RATS GROUP: 1-1 DOSE: O MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670236 670241 670245 670249 670253 670257 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 19 19 22 22 22 22 20 20 24 24 22 22 - 1343 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN F1A MALE RATS GROUP: III-l DOSE: 10 MG/K G / D A Y ANIMAL NUMBER OBSERVATION 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SORE LEFT FRONT PAW(S) COLORED DISCHARGE NOSE RED SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 FIRST DAY OBSERVED LAST DAY OBSERVED 22 22 21 21 20 20 21 21 22 22 22 22 21 21 20 20 21 21 29 40 NR 21 21 36 40 NR 36 36 20 20 22 22 20 20 - 1344Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN F1A MALE RATS GROUP: III-l DOSE: 10 M G / K G / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670311 670315 670319 670323 670328 670331 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 23 23 22 22 20 20 22 22 21 21 25 25 - 1345 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 21 21 21 22 22 19 19 25 25 20 20 20 20 25 25 22 22 22 22 21 21 21 21 22 22 22 22 - 1346Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA MALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 670391 670395 670399 670403 670407 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 40 21 21 23 23 40 40 NR 20 20 20 20 22 22 40 40 NR - 1347 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN F1A MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 21 21 22 22 25 25 20 20 21 21 23 23 20 20 21 21 22 22 22 22 22 22 23 23 25 25 23 23 - 1348Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN PIA MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670467 670471 670475 670479 670483 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 PREPUTIAL SEPARATION COMPLETE SACRIFICED BY DESIGN TEST DAY 40 20 20 23 23 23 23 21 21 22 22 - 1349 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 14 14 14 14 11 11 11 11 12 12 10 10 12 12 14 14 10 10 10 10 12 12 99 13 13 11 11 - 1350 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670541 670545 670549 670553 670557 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 99 10 10 10 10 12 12 11 11 - 1351 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P1A FEMALE RATS GROUP: IV-1 DOSE: 10 MG/K G / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 10 10 12 12 11 11 99 12 12 12 12 12 12 11 11 11 11 36 40 NR 36 40 NR 12 12 11 11 11 11 13 13 - 1352Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: IV-1 DOSE: 10 MG/KG / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670613 670617 670621 670625 670628 670632 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE .SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 99 10 10 14 14 12 12 10 10 99 - 1353 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN PIA FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 15 15 12 12 13 13 13 13 10 10 12 12 11 11 11 11 11 11 12 12 88 11 11 10 10 13 13 - 1354Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 670685 670689 670693 670697 670701 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE ENOPHTHALMUS RIGHT EYE(S) SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 11 11 13 13 15 40 NR 11 11 11 11 12 12 - 1355 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FlA FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40. VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 11 . 11 12 14 12 10 11 10 11 15 9 11 11 12 11 11 12 14 12 10 11 10 11 15 9 11 11 - 1356Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN FIA FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 670759 670763 670767 670771 670775 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 VAGINAL PATENCY COMPLETE SACRIFICED BY DESIGN TEST DAY 40 12 12 13 13 13 13 11 11 14 14 - 1357 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX KK INDIVIDUAL BODY WEIGHTS OF Fj MALE AND FEMALE RATS - 1358 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHTS OF Fi MALE AND FEMALE RATS Note EXPLANATORY NOTES Test Day 1 = Postnatal Day 21 Abbreviations = No Data - 1359 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I NDIVIDUAL BOD Y WEIGHTS (g) O F FIA M A L E RATS GROUP: 1-1 DOSE: O MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 1 8 15 22 36 54..8 64..1 78..4 53..7 58..3 53..3 68..4 61..0 55..5 75..6 65..0 59..6 60..0 67..4 62..4 53..6 49..6 50..6 59..3 88,.5 110..9 131,.5 91,.9 103,.2 103,.6 116,.3 110..1 99,.3 118,.0 118,.9 104,.3 107..0 117,.1 103..7 94..6 87..2 83..8 101..7 145 .9 183 .2 204..2 153 .3 164..4 169,.9 181..7 180,.2 158..9 186..3 195..9 169..3 174..8 186..4 171..6 154..1 158..4 125..7 165..1 210,.0 265..4 276..8 220,.3 214,.4 236,.6 244..0 256..6 223..2 254..0 268..3 245..3 239..2 260..1 238..9 219..8 222..9 177..2 229..0 331,.8 416,.4 398,.2 359,.0 333 ,.9 368..2 361,.8 404,.9 335,.4 373 ,.0 406,.4 395,.1 353 ,.3 383 ,.8 368..7 338,.1 347 ,.0 261,.2 355,.5 DuPont-11418 - 1360 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL B O D Y WEIGHTS (g) OF FI A M A L E RATS GROUP: III-l DOSE: 10 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 1 8 15 22 36 61..6 65..4 68..3 57..6 59..9 45..3 56..3 60..2 66..4 70..1 58..3 68..1 56..9 65.,4 69..2 61..2 63 .1 66..9 62..7 110..2 111..7 118..8 104..2 107..6 81..2 93..1 97..1 117..6 117..3 99..5 114..6 102..3 115..9 121..7 108..2 111..7 104..1 114..7 179..7 179..7 193 .8 170..4 174..3 133 .1 153 .1 156..3 188..6 182,.3 161..4 185..3 160..6 179..4 192..3 185..5 178..7 173..2 180..9 248 .1 237 .9 269,.1 241,.5 241 .5 200 .5 222..4 221,.3 246,.8 250..8 218..6 257..8 219..6 247..7 260..0 254..7 257..8 241..8 253 ,.0 367..7 365..9 412..0 366..2 375..2 299..1 331..2 340..7 372 .1 291..5 339..1 387..0 337..5 367..4 402..2 392,.5 386,.3 350..1 375..8 DuPont-11418 -1361 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) OF Fl A M A L E RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 1 B 15 22 36 54..6 76..5 69,.9 58..2 63..5 63..2 66..8 76..5 74..0 64..0 62..6 61..1 66..9 64..1 54..3 67..3 76..0 59..6 67..0 94..4 127..3 120..0 102..0 107..0 109..6 115..4 136..7 125..4 112..5 103..7 109.,6 117..6 108..1 97..8 121..4 132.,8 101..1 124.,6 152..6 190 .0 189 .7 160 .0 159 .9 178 .3 179 .8 213 .7 193 .0 174 .3 158..9 173 ,.7 191,.1 172 ,.2 162..2 201,.2 219,.2 161..7 204..9 212 .5 259 .9 259 .5 213 .5 217..1 245..3 246..2 295..5 260..9 246..2 228..4 245..4 262..6 236..4 225..9 289..9 284..0 217..2 277.,0 324,.1 422,.6 369 .3 317..9 346..0 377,.9 352..8 446..5 369..5 362..4 346..1 362..1 371..9 354..7 347 ..3 428..2 417.,3 - 390.,4 DuPont-11418 Data inadvertently not recorded for test day 36. - 1362 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BOD Y WEIGHTS (g) OF FI A M A L E RATS GROUP: V I 1-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 1 8 15 22 36 59.3 58.9 52.3 66.7 59.0 70.0 73.0 68.2 61.4 56.4 58.4 71.1 59.8 58.7 58.5 61.2 63.3 65.9 63.7 97..5 105..7 86..5 117.,4 102..8 113..6 128..0 118..2 106..2 111..5 98..5 118..3 102..4 91..5 101..4 103..6 114..6 109..5 113..8 153..2 175..3 141..5 190..9 174..2 173..3 197,.6 183 ,.8 167 ,.2 186..0 163 .3 183,.1 133,.4 146,.6 157 .9 173 .6 180..1 168..9 185..5 217 ,.0 241..5 182..8 260..4 246..0 233..3 264..0 247..4 214..9 256..4 229..8 249..6 205..0 201..3 223 .5 242 .4 242..3 239..0 248,.6 323.3 364.7 263.4 404.1 367.3 355.4 381.0 366.8 324.1 372.9 366.1 364.1 334.5 316.4 343.8 375.8 390.0 376.3 387.3 DuPont-11418 - 1363Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FIA FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 1 8 15 22 36 50..0 59..8 74.,8 56..2 60.,1 52.,9 65..8 64..6 53..5 70.,7 58..0 58..9 55..8 56..8 56..6 53..2 52..5 62..3 55,.8 76..2 97..4 120.,8 95..3 96..1 92..0 108..2 101..4 94,.7 117,.4 100,.2 96,.6 96,.6 92 .3 95 .6 86 .4 93,.7 102,.0 92,.1 110..5 144,.2 173 .2 141,.8 142 ,.8 129,.1 151 .2 164 .6 138 .7 166 .7 153 .6 139 .2 144 .5 135 .1 150 .2 135 .3 133 .7 149 .7 134 .6 149,.0 173 ,.5 202,.1 173..6 171..9 157..9 185..3 214,.0 178,.0 204..0 185..4 177..4 186..7 144..4 181 .3 169 .2 168,.5 186 .3 167 .5 180..2 215..9 269..1 232.,2 225..4 201.,8 259..4 282..7 237..4 255,.6 233,.2 214.,0 222..2 185,.3 235,.9 223 .0 216..6 236..6 211..9 DuPont-11418 - 1364Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FI A FEMALE RATS GROUP: IV-1 DOSE: 10 M G / K G / D A Y DAYS ON TEST: ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 1 8 15 22 36 64 .4 56..0 61,.3 58,.4 53 .5 62,.1 50,.2 57,.6 59,.9 67,.6 59..8 66,.1 59,.8 59..4 65,.6 54..5 65,.4 61..2 63,.6 108..9 92..5 101..7 99..4 86,.4 100..4 84..6 85..8 105,.9 107..6 94..5 108..3 101..0 99,.1 110..2 87,.6 115..9 105..0 Ill,.3 150..1 125..0 150..2 146..6 130..8 139,.9 119,.0 121,.8 149,.6 148..1 130,.6 156,.4 144..2 139..3 156..7 127,.4 173,.8 162..3 158..3 179..4 161,.4 197..5 185,.0 161..1 178,.6 144,.4 153..6 180,.2 175..7 155..0 197,.6 180..3 166..5 180..0 159..9 214..4 225..6 190..8 225.,2 204..6 259.,4 240..1 225..6 221..1 170..5 170..3 236.,1 231..4 197.,5 242..3 214..7 201..4 220..3 210..6 274..7 282 .6 246.,9 DuPont-11418 - 1365 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations I N DIVIDUAL B O D Y WEIGHTS (g) OF F I A FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 1 8 15 22 36 45..5 72..3 67,.1 57,.0 61,.2 55,.9 62 .3 73 .1 64,.3 60..6 65,.5 58,.7 56..1 61,.9 55..2 60..6 67 .7 51,.3 60..6 78..2 114..4 106..9 97,.8 96..6 88..5 97..2 129..9 111..0 103..8 100..9 91..1 98..2 101..1 94..3 94..7 116..6 80..5 105..9 116..5 155..7 146..0 140..7 135..4 141..2 140..4 172..6 163..7 152..4 144..0 131..9 144..2 144..3 140..1 139..8 167 ,.1 116,.8 151,.4 141.,9 168.,2 191..4 178..0 163 .3 180..1 177..6 213 .0 198..2 190..1 182..6 170..1 175..7 187..1 172..7 172..5 201..8 146..3 178,.6 180..9 228..8 235..7 224..1 213..1 236..3 218,.2 265,.2 253..5 240,.0 225..5 225,.4 223,.1 239..4 226,.4 217 .7 251 .5 219 .0 DuPont-11418 " Data inadvertently not recorded for test day 36. - 1366Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS (g) OF FI A FEMALE RATS GROUP: V I I I -1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 1.8 15 22 36 58.8 60.3 51.9 55.9 52.5 64.3 69.3 58.8 58.8 55.6 52.9 68.9 56.3 61.2 56.8 57.9 58.8 57.4 64.3 98..1 114..7 79.,8 94..5 85.,6 98..2 121..6 91..2 94..7 107..4 92..3 120..3 92..4 97..1 97..3 95..7 100..8 93..3 115..0 137..0 168..3 116..9 141..2 132..1 146..7 183..0 132 ,.5 140..0 160..7 135,.8 165,.3 141,.1 133,.5 139,.4 139 .0 148,.8 134 .1 168 .6 162..0 200..9 141..7 181..9 162..8 182..7 222..6 156..2 161,.6 187..4 163..4 203..4 187..8 169,.0 171 .4 176 .0 194 .6 159 .9 194 .1 191.3 254.7 171.1 215.5 212.2 223.2 274.7 189.5 189.4 241.2 205.2 248.1 248.9 198.5 235.3 229.9 253.1 217.8 249.7 DuPont-11418 - 1367 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX LL INDIVIDUAL BODY WEIGHT GAINS OF Fi MALE AND FEMALE RATS - 1368Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHT GAINS OF Fi MALE AND FEMALE RATS Note EXPLANATORY NOTES Test Day 1 = Postnatal Day 21 Abbreviation = No Data - 1369 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ I NDIVIDUAL BOD Y WEIGHT GAINS (g) OF F I A M A L E RATS GROUP: 1-1 DOSE: O MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 1-8 8-15 15-22 22-36 1-36 33.7 46.8 53.1 38.2 44.9 50.3 47.9 49.1 43.8 42.4 53.9 44.7 47.0 49.7 41.3 41.0 37.6 33.2 42.4 57.4 72.3 72.7 61.4 61.2 66.3 65.4 70.1 59.6 68.3 77.0 65.0 67.8 69.3 67.9 59.5 71.2 41.9 63.4 64..1 82..2 72..6 67..0 50..0 66..7 62..3 76..4 64..3 67..7 72..4 76..0 64,.4 73..7 67 .3 65 .7 64..5 51..5 63,.9 121..8 151..0 121..4 138.,7 119.,5 131..6 117.,8 148..3 112..2 119..0 138..1 149..8 114..1 123 .,7 129,.8 118..3 124..1 84..0 126..5 277..0 352..3 319..8 305..3 275..6 314..9 293 .4 343 .9 279..9 297..4 341..4 335,.5 293 ,.3 316,.4 306 .3 284 .5 297,.4 210..6 296..2 DuPont-11418 - 1370Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA MALE RATS GROUP: III-l DOSE: 10 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 1-8 8-15 15-22 22-36 1-36 48,.6 46,.3 50,.5 46,.6 47,.7 35..9 36..8 36..9 51..2 47..2 41..2 46..5 45..4 50..5 52..5 47..0 48,.6 37,.2 52,.0 69..5 68..0 75..0 66..2 66..7 51..9 60..0 59..2 71..0 65..0 61..9 70,.7 58,.3 63,.5 70..6 77..3 67 ,.0 69,.1 66 .2 68..4 58..2 75,.3 71,.1 67,.2 67..4 69..3 65,.0 58..2 68,.5 57,.2 72,.5 59 .0 68 .3 67 .7 69..2 79 .1 68 .6 72 .1 119..6 128..0 142..9 124..7 133..7 98.,6 108..8 119..4 125,.3 40,.7 120,.5 129..2 117,.9 119,.7 142 .2 137,.8 128,.5 108 .3 122 .8 306.,1 300..5 343,.7 308,.6 315..3 253..8 274..9 280..5 305..7 221..4 280..8 318,.9 280,.6 302 .0 333,.0 331 .3 323 .2 283 .2 313 .1 DuPont-11418 - 1371 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA WALE RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 1-8 8-15 15-22 22-36 1-36 39..8 50..8 50..1 43..8 43,.5 46..4 48,.6 60..2 51..4 48..5 41..1 48..5 50..7 44..0 43..5 54..1 56..8 41..5 57 .6 58..2 62.,7 69..7 58..0 52..9 68..7 64..4 77..0 67..6 61..8 55..2 64,.1 73,.5 64..1 64..4 79..8 86..4 60..6 80..3 59.,9 69.,9 69..8 53.,5 57 .2 67..0 66..4 81..8 67..9 71..9 69..5 71..7 71..5 64..2 63..7 88..7 64..8 55,.5 72,.1 111. 6 162. 7 109. 8 104. 4 128. 9 132. 6 106. 6 151. 0 108. 6 116. 2 117. 7 116. 7 109. 3 118. 3 121..4 138. 3 133. 3 113..4 269..5 346..1 299..4 259..7 282..5 314,.7 286..0 370..0 295..5 298,.4 283..5 301..0 305..0 290..6 293 .0 360..9 341 .3 323 .4 DuPont-11418 ..................... ........... -- a Data for interval could not be calculated; data inadvertently not recorded for test day 36. - 1372Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BOD Y W E I G H T GAINS (g) OF F 1 A M A L E RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 1-8 8-15 15-22 22-36 1-36 38.2 46.8 34.2 50.7 43.8 43.6 55.0 50.0 44.8 55.1 40.1 47.2 42.6 32.8 42.9 42.4 51.3 43.6 50.1 55.7 69.6 55.0 73.5 71.4 59.7 69.6 65.6 61.0 74.5 64.8 64.8 31.0 55.1 56.5 70.0 65.5 59.4 71.7 63.8 66.2 41.3 69.5 71.8 60.0 66.4 63.6 47.7 70.4 66.5 66.5 71.6 54.7 65.6 68.8 62.2 70.1 63.1 106.3 123.2 80.6 143.7 121.3 122.1 117.0 119.4 109.2 116.5 136.3 114.5 129.5 115.1 120.3 133.4 147.7 137.3 138.7 264.0 305.8 211.1 337.4 308.3 285.4 308.0 298.6 262.7 316.5 307.7 293.0 274.7 257.7 285.3 314.6 326.7 310.4 323.6 DuPont-11418 - 1373 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEI G H T GAINS (g) OF F I A FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 1-8 8-15 15-22 22-36 1-36 26..2 37,.6 46..0 39,.1 36..0 39,.1 42..4 36..8 41..2 46,.7 42,.2 37..7 40,.8 35..5 39..0 33..2 41,.2 39,.7 36..3 34,.3 46,.8 52..4 46..5 46,.7 37,.1 43..0 63..2 44..0 49..3 53,.4 42..6 47..9 42..8 54..6 48.,9 40..0 47..7 42..5 38..5 29..3 28..9 31..8 29..1 28..8 34..1 49..4 39,.3 37,.3 31..8 38..2 42..2 9..3 31..1 33..9 34..8 36..6 32..9 31,.2 42,.4 67..0 58,.6 53 ,.5 43..9 74..1 68..7 59..4 51..6 47..8 36..6 35..5 40..9 54..6 53 .8 48..1 50..3 44..4 130..2 156..1 194..3 176..0 165..3 148..9 193..6 218..1 183..9 184..9 175..2 155..1 166..4 128..5 179..3 169,.8 164..1 174..3 156..1 DuPont-11418 - 1374Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHT GAINS (g) OF FIA FEMALE RATS GROUP: IV-1 DOSE: 10 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 1--8 8-:15 15-:22 22-:36 1-36 44,.5 36,.5 40,.4 41,.0 32 ,.9 38,.3 34,.4 28,.2 46..0 40..0 34..7 42 ,.2 41..2 39..7 44..6 33..1 50..5 43..8 47..7 41 .2 32 .5 48 .5 47 .2 44 .4 39 .5 34 .4 36 .0 43 .7 40 .5 36 .1 48 .1 43 .2 40 .2 46 .5 39 .8 57 .9 57 .3 47 .0 29 .3 36 .4 47 .3 38 .4 30 .3 38 .7 25 .4 31 .8 30 .6 27 .6 24 .4 41 .2 36 .1 27 .2 23 .3 32 .5 40 .6 63 .3 32 .5 45 .8 43 .2 61 .9 55 .1 64 .5 42 .5 26 .1 16 .7 55 .9 55 .7 42 .5 44 .7 34 .4 34 .9 40 .3 50 .7 60 .3 57 .0 56 .1 160.8 148.6 198.1 181.7 172.1 159.0 120.3 112.7 176.2 163.8 137.7 176.2 154.9 142.0 154.7 156.1 209.3 221.4 183.3 DuPont-11418 - 1375 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL B O D Y WEI G H T GAINS (g) OF F I A FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 1-8 8-15 15-22 22-36 1-36 32,.7 42,.1 39,.8 40..8 35,.4 32,.6 34,.9 56,.8 46,.7 43 ,.2 35,.4 32,.4 42,.1 39,.2 39,.1 34..1 48,.9 29,.2 45..3 38..3 41,.3 39,.1 42,.9 38,.8 52,.7 43,.2 42,.7 52,.7 48,.6 43..1 40,.8 46..0 43..2 45..8 45..1 50..5 36..3 45..5 25 .4 12 .5 45 .4 37 .3 27 .9 38 .9 37,.2 40,.4 34,.5 37,.7 38,.6 38,.2 31..5 42,.8 32..6 32..7 34,.7 29..5 27..2 39. 0 60. 6 44. 3 46. 1 49. 8 56. 2 40. 6 52. 2 55. 3 49. 9 42. 9 55. 3 47. 4 52. 3 53. 7 45. 2 49. 7 40. 4 135 .4 156 .5 168..6 167 .1 151..9 180,.4 155,.9 192..1 189..2 179..4 160..0 166..7 167..0 177..5 171,.2 157..1 183.,8 --a 158..4 DuPont-11418 Data for interval could not be calculated; data inadvertently not recorded for test day 36. - 1376 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY W E I G H T GAINS (g) OP F IA FEMALE RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 1-8 8-15 15-22 22-36 1-36 39.,3 54,.4 27..9 38..6 33,.1 33 .9 52 ,.3 32 ,.4 35,.9 51..8 39,.4 51,.4 36..1 35,.9 40,.5 37,.8 42,.0 35,.9 50,.7 38..9 53..6 37..1 46..7 46,.5 48..5 61,.4 41..3 45,.3 53..3 43..5 45,.0 48,.7 36..4 42,.1 43,.3 48,.0 40.,8 53..6 25..0 32..6 24..8 40,.7 30..7 36..0 39,.6 23..7 21..6 26..7 27,.6 38..1 46..7 35..5 32 ,.0 37 .0 45..8 25,.8 25..5 29,.3 53..8 29..4 33..6 49,.4 40..5 52,.1 33,.3 27..8 53,.8 41..8 44..7 61..1 29,.5 63,.9 53,.9 58,.5 57,.9 55,.6 132..5 194..4 119..2 159..6 159,.7 158,.9 205,.4 130,.7 130..6 185..6 152,.3 179..2 192..6 137..3 178..5 172,.0 194..3 160..4 185..4 DuPont-11418 - 1377 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX MM INDIVIDUAL FOOD CONSUMPTION OF Fj MALE AND FEMALE RATS - 1378 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY F1A MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 1-8 8-15 15-22 22-36 1-36 9..6 13 .3 13 .9 10..4 12,.8 12 .8 12..7 11,.9 12..1 12..1 13..0 12 .6 12..8 13 .4 11..6 11,.2 9,.5 10,.5 11,.3 16..3 21..4 22..5 17,.2 19,.9 20..9 20..4 20,.3 18,.8 20,.3 22,.4 19,.5 20,.5 20,.3 18,.8 17,.8 17,.9 13,.1 18,.4 21,.9 29,.1 27,.7 22,.8 23 .2 27 .9 25,.2 29 .4 24 .6 26 .0 27 .6 27 .1 25 .6 27 .1 25 .8 22 .6 23 .0 17 .1 22 .7 25..9 35..3 31..1 28..8 28..6 31..7 27..1 34,.4 25,.8 29,.0 30..6 32 ,.8 28..8 30..1 29,.1 28,.1 27,.2 19,.0 27,.4 19..9 26..9 25..3 21..6 22..6 25..0 22..5 26..1 21..4 23..3 24..9 24..9 23..3 24.,2 22,.9 21..6 20..9 15,.7 21,.4 DuPont-11418 - 1379 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY F1A MALE RATS GROUP: III-l DOSE: 10 MG/KG / D A Y DAYS ON TEST: ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 1-8 8-15 15-22 22-36 1-36 12..8 13..5 13..0 13..4 12..6 9.,8 10..2 11..2 14..2 13..1 10,.7 13,.2 12..6 13,.0 16,.0 13..6 12 .9 12 .7 14,.9 21..6 19..9 21..4 19..9 19..9 15..5 17,.2 17..8 20..8 20.,6 17..3 21..6 18..6 20..0 23..3 21,.7 21..1 19..1 21 .4 26..8 24..6 27..7 26..6 25..5 23..2 24..0 23 .5 25,.2 24..9 19..2 26,.6 23,.6 25 .0 28 .1 27 .3 30 .0 25 .9 26 .9 28..3 30.,3 33.,9 30..0 30..9 25..8 27..3 26..9 28,.4 24..1 26..9 31..3 28..3 29..6 32..2 31,.7 33,.0 28..3 30..9 23..6 23,.7 26..0 24,.0 24..0 20..0 21..2 21..3 23..4 21..3 20..2 24..8 22,.3 23..5 26,.3 25..2 26..0 22..8 25 .0 DuPont-11418 - 1380Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ DuPont-11418 INDIVIDUAL FOOD C O NSUMPTION (g/day) BY F I A M A L E RATS GROUP: V-l DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 1-8 8-15 15-22 22-36 1-36 11..2 14..1 12..9 12..0 11,.5 12..6 13..1 15..3 14..2 13 .3 11..8 13.,0 14..1 12..4 11..0 13..5 14..6 10.,6 14..4 18,.1 20..7 20..8 17..9 16..8 20..0 18..7 24..4 22..1 18..6 16..6 20..7 22..2 19..1 18..6 23..8 26..1 17..1 24..6 23 ,.5 27..5 26..8 21..7 19,.7 25 .5 24..8 29 .7 27,.5 25 .3 23 .0 28,.3 27 .9 23,.4 22,.7 31,.8 31 .4 21 .1 31 .1 26..6 35..4 26..6 24,.7 25..2 28,.7 26,.4 34,.4 29..0 28..1 26..3 29..9 28..5 25..5 26..2 32,.8 35,.2 44,.6 30,.8 21,.2 26..6 22..7 20,.2 19..7 23..1 21,.9 27,.7 24..3 22..7 20,.8 24,.4 24..3 21..2 20,.9 27 .0 28..5 27..6 26,.3 - 1381 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________ INDIVIDUAL FOOD CONSUMPTION (g/day) BY F1A MALE RATS GROUP: VII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 1--8 8-:15 15-22 22-36 1-36 11,.3 12,.5 10,,2 13.,3 11,.4 12,.0 14,.3 14,,0 12,.5 13,,7 11,,0 12,,9 11,.7 10,,5 11,.6 11,,9 12,.8 12,.9 13,.2 16 .9 21 .3 16 .4 20 .8 20 .1 18 .8 23 .0 20 .7 18 .3 21 .7 18 .2 19 .2 13 .7 16 .5 17 .4 21 .1 19 .3 19 .1 21 .7 21 .5 27 .5 20 .0 27 .5 25 .9 20 .1 28 .1 26 .2 21 .2 26 .6 24 .5 25 .2 23 .5 20 .6 23 .8 26 .0 24 .3 24 .4 25 .4 25 .4 30 .9 22 .0 32 .4 30 .1 27 .3 30 .4 28 .6 23 .0 29 .1 30 .9 28 .9 27 .3 24 .5 26 .3 31 .4 29 .1 29 .7 30 .3 20.1 24.6 18.1 25.3 23.5 21.1 25.2 23.6 19.6 24.0 23.1 23.0 20.7 19.3 21.1 24.3 22.9 23.2 24.2 DuPont-11418 - 1382 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY F1A FEMALE RATS GROUP: II-l DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 1-8 8-15 15-22 22-36 1-36 9..8 11..8 13 .1 11 .1 10..8 11..5 12..3 10..4 11..8 12..1 11..0 10..7 12..1 11..1 9.,9 10.,0 11..6 12..5 11..2 12,.2 16..7 20 .1 16..3 15,.3 14..6 16,.3 17..6 16..6 17.,2 16..2 16..1 17..4 16.,3 16.,6 16.,0 15..1 19..0 15..2 16..5 17..9 21 .3 18 .5 17 .4 17 .0 19 .7 22,.0 19..6 19..9 18..2 19..8 21..3 16..9 19..3 17..8 16,.3 20,.1 16..9 15,.4 18..9 24 .2 18 .9 20 .5 17 .2 21..9 21..9 18..0 19..2 18..2 18..0 21..3 16..9 19..6 18..9 17,.4 21,.4 17,.5 13 .9 16..9 20,.6 16 .8 16..9 15,.5 18..4 18..7 16,.8 17..6 16..4 16,.5 18,.7 15..6 17 ,.0 16..3 15,.5 18,.9 15..7 DuPont-11418 - 1383 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUM P T I O N (g/day) BY F 1A FEMALE RATS GROUP: IV-1 DOSE: 10 M G/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 1-8 8-15 15-22 22-36 1-36 14 .4 10,.1 11,.6 12 ,.4 10,.7 12 ,.0 10,.1 10,.0 12 ,.1 11,.8 11,.0 12,.6 12 ,.6 11,.8 13 ,.4 9,.4 13 ,.3 11,.6 13 ,.6 17,.5 15,.1 17,.3 17,.2 15,.5 17,.1 14,.3 13,.6 16,.9 17,.4 14,.9 17,.6 17,.2 15,.2 19,.8 14,.7 21,.6 19 .5 19,.3 19..0 18..5 20..6 20..5 17,.0 19 ,.7 15 ,.7 15 .3 18..6 18,.0 14,.0 19,.1 19 ,.9 15..8 20,.7 16..6 22 .9 26..3 19,.0 19..1 18..7 22..2 20..0 19..5 18,.2 14..2 13 ,.7 19,.5 18..6 14 .9 19..3 18 .6 16,.9 20..1 17 .5 23 .1 25 .9 21 .4 17.8 16.2 18.8 18.0 16.4 17.0 13.7 13.2 17.3 16.9 13.9 17.6 17.4 15.3 18.8 15.2 20.8 21.8 18.9 DuPont-11418 - 1384Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL FOOD CONSUMPTION (g/day) BY FIA FEMALE RATS GROUP: VI-I DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 1--8 8-:15 15-:22 2 2 -:36 1-:36 10 .4 12 .4 12 .1 11 .1 11,.1 10,.4 10..4 15,.2 12,.7 13..3 11..6 11..4 11..2 11..7 10..5 9..9 13..7 8..0 12..0 14 .9 17 .6 17 .0 15 .5 14 .5 15 .7 14 .8 20 .5 19 .1 17 .7 16 .3 15 .9 17 .2 15 .8 14 .7 16 .1 19 .1 11 .9 18 .0 15 .4 16 .6 19 .3 17 .6 15 .9 18 .9 18 .2 20 .3 21 .0 21 .0 18 .7 20 .3 18 .4 19 .3 17 .6 17 .6 21 .7 14 .7 20 .2 17 .1 17 .7 19 .9 17 .7 16 .7 19 .5 17 .2 20 .0 22 .2 20 .2 18 .2 20 .5 18 .2 18 .9 17 .6 17 .9 20 .3 32 .0 19 .0 15 .0 16 .4 17 .6 15 .9 15 .0 16 .8 15 .6 19 .2 19 .5 18 .5 16 .6 17 .7 16 .7 16 .9 15 .6 15 .9 19 .0 19 .7 17 .7 DuPont-11418 - 1385 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _________________ DuPont-11418 INDIVIDUAL FOOD CONSUMPTION (g/day) BY F I A FEM A L E RATS GROUP: VIII-1 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 1-8 8-15 15-22 22-36 1-36 11 .7 14..0 10..7 10,.7 11..4 10..2 14..9 10..8 11..6 14..0 12..0 14..1 10..4 10,.8 10..9 11..5 12..2 11..2 13..5 15 .7 20 .2 14 .5 15 .3 16..9 16..0 21..6 14,.6 17,.6 20.,4 16..0 19..9 15..9 15..1 15,.6 17..2 17..3 15,.7 20,.0 16,.1 20..5 16,.8 18..7 18..6 18..3 23 .8 16..2 16,.7 20,.0 17..4 19..8 20..1 16,.8 18..0 18,.6 20,.5 17..6 19..9 16,.2 22..8 17,.2 17..8 19,.8 18..2 23 ,.6 16..1 16,.4 21,.3 18,.9 19,.4 20,.6 17 .0 19..5 19 .4 20 .5 18..8 19..9 15..2 20..0 15..3 16..1 17..3 16..2 21..5 14..8 15..7 19..4 16..6 18..5 17..5 15,.3 16,.7 17,.2 18,.2 16,.4 18,.7 - 1386Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX NN INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS - 1387 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations f' EPIDID - EPIDIDYMIDES NW - NOT WEIGHED KEY OF ABBREVIATIONS DuPont-11418 - 1388 Company Sanitized. Does not contain TSCA CBI )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : 1-1 - O mg/kg ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 FINAL BODY 365.1 459.9 426.1 392.4 371.4 396.8 383.1 432.6 361.5 404.0 439.7 434.4 380.2 418.1 403.6 358.4 384.9 279.4 383.7 LIVER 20.580 22.150 17.301 17.980 17.213 18.008 17.392 22.068 16.541 '19.248 19.736 24.143 15.416 18.601 19.964 16.931 15-074 10.322 16.813 THYROID GLAND 0.030 0.018 0.024 0.035 0.012 0.022 0.015 0.019 0.021 0.021 0.024 0.019 0.023 0.025 0.020 0.021 0.018 0.013 0.022 TESTES 2.876 3.258 3.603 3.171 3.192 3.086 3.221 3.071 3.024 2.181 3.334 3.160 3.016 3.452 2.753 3.367 3.017 2.825 3.089 EPIDID 0.655 0.836 0.756 0.665 0.811 0.732 0.807 0.709 0.625 0.618 0.753 0.750 0.713 0.788 0.676 0.701 0.747 0.741 0.672 Company Sanitized. Does not contain TSCA CBI - 1389 - WEIGHTS - FI ADULTS PROSTATE 0.507 0.431 0.466 0.457 0.357 0.516 0.386 0.374 0.453 0.344 0.574 0.571 0.387 0.405 0.611 0.420 0.587 0.315 0.373 SEMINAL VESICLES 1.173 1.371 1.368 1.364 1.292 1.418 1.394 1.296 1.138 0.990 1.460 1.248 1.306 1.133 1.344 1.444 1.641 1.129 1.160 BRAIN 1.809 1.863 1.993 1.920 1.871 1.950 1.994 2.059 1.932 1.987 1.979 1.915 2.107 1.976 1.892 1.971 2.082 1.858 2.015 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : III-l - 10 mg/kg ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 FINAL BODY 384.6 396.8 446.7 396.1 413.3 312.8 361.8 370.2 400.1 366.3 379.0 419.1 359.5 401.0 441.1 427.9 422.4 380.2 408.2 LIVER 17.960 15.705 20.060 19.083 19.741 13.975 18.929 17.032 17.361 16.033 18.538 21.116 15.425 19.070 20.546 19.507 20.263 17.519 17.830 THYROID GLAND 0.024 0.015 0.023 0.021 0.011 0.020 0.019 0.019 0.017 0.017 0.020 0.014 0.017 0.015 0.021 0.029 0.013 0.016 0.020 TESTES 3.193 3.607 3.474 3.164 2.905 3.391 2.865 3.116 3.276 3.068 2.834 3.041 3.046 3.249 3.242 3.885 3.033 3.248 2.969 EPIDID 0.811 0.789 0.823 0.759 0.710 0.604 0.592 0.813 0.816 0.707 0.716 0.747 0.613 0.788 0.772 0.825 0.740 0.782 0.679 Company Sanitized. Does not contain TSCA CBI - 1390 - WEIGHTS - FI ADULTS PROSTATE 0.544 0.497 0.509 0.515 0.329 0.502 0.413 0.489 0.595 0.442 0.530 0.439 0.458 0.522 0.402 0.479 0.428 0.445 0.490 SEMINAL VESICLES 1.554 1.237 1.391 1.317 1.225 1.494 1.113 1.663 1.481 1.336 1.451 1.443 1.224 1.518 1.389 1.033 1.212 1.337 1.201 BRAIN 2.007 1.938 2.007 1.919 2.137 1.815 1.779 1.987 2.064 1.900 1.880 2.242 1.843 2.011 2.098 2.075 1.996 1.880 1.958 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN FINAL BODY AND ABSOLUTE ORG^N WEIGHTS (grams) FROM MALE RATS GROUP : V-l - 100 mg/kg ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 FINAL BODY 349.0 454.9 397.4 340.7 373.7 407.5 378.7 474.7 391.9 392.0 371.4 393.1 392.1 387.4 378.9 458.8 448.1 338.7 416.8 LIVER 17.472 22.349 17.241 14.501 . 17.441 17.969 15.742 22.225 17.688 18.445 16.939 20.554 15.950 15.926 16.036 20.192 18.628 14.850 19.579 THYROID GLAND 0.016 0.020 0.025 0.022 0.019 0.032 0.026 0.018 0.020 0.020 0.022 0.016 0.025 0.017 0.013 0.020 0.027 0.023 0.020 TESTES 2.957 3.905 3.535 3.210 3.075 4.618 2.927 3.446 3.307 2.783 3.254 3.167 3.198 3.577 3.069 3.527 3.513 3.291 3.430 EPIDID 0.667 0.936 0.979 0.720 0.663 0.900 0.691 0.791 0.834 0.696 0.700 . 0.763 0.780 0.800 0.782 0.779 0.927 0.720 0.898 Company Sanitized. Does not contain TSCA CBI -1391- WEIGHTS - Fl ADULTS PROSTATE 0.291 0.615 0.428 0.334 0.366 0.487 0.485 0.507 0.616 0.514 0.457 0.513 0.438 0.556 0.693 0.578 0.410 0.267 0.496 SEMINAL VESICLES 1.293 1.301 1.174 0.996 1.176 1.530 1.495 1.275 1.302 1.302 1.269 1.436 1.568 1.273 1.281 1.872 1.386 1.237 1.480 BRAIN 1.936 2.154 1.994 ' 1.874 1.927 1.981 2.076 2.069 2.121 2.000 1.939 1.868 1.971 2.008 1.903 1.989 2.078 1.789 1.916 DuPont-11418 )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM MALE RATS GROUP : VII-1 - 1000 mg/kg ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 FINAL BODY 351.7 393.5 281.8 437.7 410.5 384.5 406.8 393.6 352.2 399.6 401.0 392.7 363.9 343.1 367.0 407.7 427.8 403.5 418.4 LIVER 15.618 19.961 11.220 22.816 18.797 16.966 17.085 19.088 15.954 17.667 18.926 16.928 17.806 15.483 17.097 19.770 20.189 18.427 18.058 THYROID GLAND 0.022 0.010 NW 0.035 0.026 0.019 0.020 0.018 0.022 0.015 0.014 0.017 0.017 0.023 0.030 0.021 0.016 0.021 0.023 TESTES 3.153 3.114 2.886 3.242 3.077 3.023 3.129 3.332 3.153 3.473 3.207 3.436 3.107 2.989 3.228 3.159 3.466 3.190 3.436 EPIDID 0.704 0.639 0.711 0.808 0.698 0.698 0.814 0.751 0.681 0.808 0.830 0.680 0.755 0.669 0.793 0.662 0.666 0.845 0.715 Company Sanitized. Does not contain TSCA CBI - 1392 - WEIGHTS - FI ADULTS PROSTATE 0.491 0.367 0.393 0.633 0.415 0.378 0.471 0.339 0.436 0.334 0.382 0.491 0.421 0.413 0.531 0.365 0.448 0.435 0.511 SEMINAL VESICLES 1.246 0.844 0.977 1.746 1.372 1.019 1.261 1.238 1.326 1.167 1.409 1.139 1.065 1.102 1.603 0.984 1.160 1.616 1.459 BRAIN 1.788 1.794 1.856 1.910 2.027 1.877 1.960 1.957 1.888 2.012 1.944 1.992 1.954 1.847 1.796 1.895 1.973 1.982 1.947 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : 1-1 - O mg/kg ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 LIVER 5.637 4.816 4.060 4.582 4.635 4.538 4.540 5.101 4.576 4.764 4.489 5.558 4.055 4.449 4.946 4.724 4.696 3.694 4.382 THYROID GLAND 0.008 0.004 0.006 0.009 0.003 0.006 0.004 0.004 0.006 0.005 0.005 0.004 0.006 0.006 0.005 0.006 0.005 0.005 0.006 TESTES 0.788 0.708 0.846 0.808 0.859 0.778 0.841 0.710 0.837 0.540 0.758 0.727 0.793 0.826 0.682 0.939 0.784 1.011 0.805 EPIDID 0.179 0.182 0.177 0.169 0.218 0.184 0.211 0.164 0.173 0.153 0.171 0.173 0.188 0.188 0.167 0.196 0.194 0.265 0.175 PROSTATE 0.139 0.094 0.109 0.116 0.096 0.130 0.101 0.086 0.125 0.085 0.131 0.131 0.102 0.097 0.151 0.117 0.153 0.113 0.097 Company Sanitized. Does not contain TSCA CBI - 1393 - WEIGHTS - FI ADULTS SEMINAL VESICLES 0.321 0.298 0.321 0.348 0.348 0.357 0.364 0.300 0.315 0.245 0.332 0.287 0.344 0.271 0.333 0.403 0.426 0.404 0.302 BRAIN 0.495 0.405 0.468 0.489 0.504 0.491 0.520 0.476 0.534 0.492 0.450 0.441 0.554 0.473 0.469 0.550 0.541 0.665 0.525 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : III-l - 10 mg/kg ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 LIVER 4.670 3.958 4.491 4.818 4.776 4.468 5.232 4.601 4.339 4.377 4.891 5.038 4.291 4.756 4.658 4.559 4.797 4.608 4.368 THYROID GLAND 0.006 0.004 0.005 0.005 0.003 0.006 0.005 0.005 0.004 ' 0.005 0.005 0.003 0.005 0.004 0.005 p.007 0.003 0.004 0.005 TESTES 0.830 0.909 0.778 0.799 0.703 1.084 0.792 0.842 0.819 0.838 0.748 0.726 0.847 0.810 0.735 0.908 0.718 0.854 0.727 EPIDID 0.211 0.199 0.184 0.192 0.172 0.193 0.164 0.220 0.204 0.193 0.189 0.178 0.171 0.197 0.175 0.193 0.175 0.206 0.166 PROSTATE 0.141 0.125 0.114 0.130 0.080 0.160 0.114 0.132 0.149 0.121 0.140 0.105 0.127 0.130 0.091 0.112 0.101 0.117 0.120 Company Sanitized. Does not contain TSCA CBI - 1394 - WEIGHTS - FI ADULTS SEMINAL VESICLES 0.404 0.312 0.311 0.332 0.296 0.478 0.308 0.449 0.370 0.365 0.383 0.344 0.340 0.379 0.315 0.241 0.287 0.352 0.294 BRAIN 0.522 0.488 0.449 0.484 0.517 0.580 0.492 0.537 0.516 0.519 0.496 0.535 0.513 0.501 0.476 0.485 0.473 0.494 0.480 DuPont-11418 J) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : V-l - 100 mg/kg ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 LIVER 5.006 4.913 4.338 4.256 4.667 4.410 4.157 4.682 4.513 4.705 4.561 5.229 4.068 4.111 4.232 4.401 4.157 4.384 4.697 THYROID GLAND - 0.005 0.004 0.006 0.006 .005 0.008 0.007 0.004 0.005 ' 0.005 0.006 0.004 0.006 0.004 0.003 0.004 0.006 0.007 0.005 TESTES 0.847 0.858 0.890 0.942 0.823 1.133 0.773 0.726 0.844 0.710 0.876 0.806 0.816 0.923 0.810 0.769 0.784 0.972 0.823 EPIDID 0.191 0.206 0.246 0.211 0.177 0.221 0.182 0.167 0.213 0.178 0.188 0.194 0.199 0.207 0.206 0.170 0.207 0.213 0.215 PROSTATE 0.083 0.135 0.108 0.098 0.098 0.120 0.128 0.107 0.157 0.131 0.123 0.131 0.112 0.144 0.183 0.126 0.091 0.079 0.119 Company Sanitized. Does not contain TSCA CBI - 1395 - WEIGHTS - FI ADULTS SEMINAL VESICLES 0.370 0.286 0.295 0.292 0.315 0.375 0.395 0.269 0.332 0.332 0.342 0.365 0.400 0.329 0.338 0.408 0.309 0.365 0.355 BRAIN 0.555 0.474 0.502 0.550 0.516 0.486 0.548 0.436 0.541 0.510 0.522 0.475 0.503 0.518 0.502 0.434 0.464 0.528 0.460 DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN RELATIVE ORGAN WEIGHTS (% of body weight) FROM MALE RATS GROUP : VII-1 - 1000 mg/kg ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 LIVER 4.441 5.073 3.982 5.213 4.579 4.412 4.200 4.850 4.530 4.421 4.720 4.311 4.893 4.513 4.659 4.849 4.719 4.567 4.316 THYROID GLAND 0.006 0.003 NW 0.008 0.006 0.005 0.005 0.005 0.006 ' 0.004 0.003 0.004 0.005 0.007 0.008 0.005 0.004 0.005 0.005 TESTES 0.897 0.791 1.024 0.741 0.750 0.786 0.769 0.847 0.895 0.869 0.800 0.875 0.854 0.871 0.880 0.775 0.810 0.791 0.821 EPIDID 0.200 0.162 0.252 0.185 0.170 0.182 0.200 0.191 0.193 0.202 0.207 0.173 0.207 0.195 0.216 0.162 0.156 0.209 0.171 PROSTATE 0.140 0.093 0.139 0.145 0.101 0.098 0.116 0.086 0.124 0.084 0.095 0.125 0.116 0.120 0.145 0.090 0.105 0.108 0.122 Company Sanitized. Does not contain TSCA CBI - 1396 - WEIGHTS - FI ADULTS SEMINAL VESICLES 0.354 0.214 0.347 0.399 0.334 0.265 0.310 0.315 0.376 0.292 0.351 0.290 0.293 0.321 0.437 0.241 0.271 0.400 0.349 BRAIN 0.508 0.456 0.659 0.436 0.494 0.488 0.482 0.497 0.536 0.504 0.485 0.507 0.537 0.538 0.489 0.465 0.461 0.491 0.465 DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : 1-1 - O mg/kg ANIMAL NUMBER 670186 670190 670194 670196 670200 670204 670208 670212 670216 670220 670224 670228 670232 670236 670241 670245 670249 670253 670257 LIVER 11.376 11.889 8.681 9.365 9.200 9.235 8.722 10.718 8.562 9.687 9.973 12.607 7.317 9.413 10.552 8.590 8.681 5.555 8.344 THYROID GLAND 0.017 0.010 0.012 0.018 0.006 0.011 0.008 0.009 0.011 Q .Oil 0.012 0.010 0.011 0.013 0.011 0.011 0.009 0.007 0.011 TESTES 1.590 1.749 1.808 1.652 1.706 1.583 1.615 1.492 1.565 1.098 1.685 1.650 1.431 1.747 1.455 1.708 1.449 1.520 1.533 EPIDID 0.362 0.449 0.379 0.346 0.433 0.375 0.405 0.344 0.323 0.311 0.380 0.392 0.338 0.399 0.357 0.356 0.359 0.399 0.333 PROSTATE 0.280 0.231 0.234 0.238 0.191 0.265 0.194 0.182 0.234 0.173 0.290 0.298 0.184 0.205 0.323 0.213 0.282 0.170 0.185 SEMINAL VESICLES 0.648 0.736 0.686 0.710 0.691 0.727 0.699 0.629 0.589 0.498 0.738 0.652 0.620 0.573 0.710 0.733 0.788 0.608 0.576 DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1397 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : III-l - 10 mg /kg ANIMAL NUMBER 670261 670265 670269 670271 670275 670279 670283 670287 670291 670295 670299 670303 670307 670311 670315 670319 670323 670328 670331 LIVER 8.949 8.104 9.995 9.944 9.238 7.700 10.640 8.572 8.411 8.438 9.861 9.418 8.370 9.483 9.793 9.401 10.152 9.319 9.106 THYROID GLAND 0.012 0.008 0.011 0.011 0.005 0.011 0.011 0.010 0.008 ' 0.009 0.011 0.006 0.009 0.007 0.010 0.014 0.007 . 0.009 0.010 TESTES 1.591 1.861 1.731 1.649 1.359 1.868 1.610 1.568 1.587 1.615 1.507 1.356 1.653 1.616 1.545 1.872 1.520 1.728 1.516 EPIDID 0.404 0.407 0.410 0.396 0.332 0.333 0.333 0.409 0.395 0.372 0.381 0.333 0.333 0.392 0.368 0.398 0.371 0.416 0.347 PROSTATE 0.271 0.256 0.254 0.268 0.154 0.277 0.232 0.246 0.288 0.233 0.282 0.196 0.249 0.260 0.192 0.231 0.214 0.237 0.250 SEMINAL VESICLES 0.774 0.638 0.693 0.686 0.573 0.823 0.626 0.837 0.718 0.703 0.772 0.644 0.664 0.755 0.662 0.498 0.607 0.711 0.613 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI 1398 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : V-l - 100 mg/kg ANIMAL NUMBER 670335 670339 670340 670347 670351 670355 670359 670363 670367 670371 670375 670379 670382 670387 670391 670395 670399 670403 670407 LIVER 9.025 10.376 8.646 7.738 9.051 9.071 7.583 10.742 8.339 9.222 8.736 11.003 8.092 7.931 8.427 10.152 8.964 8.301 10.219 THYROID GLAND 0.008 0.009 0.013 0.012 0.010 0.016 0.013 0.009 0.009 ' 0.010 0.011 0.009 0.013 0.008 0.007 0-010 0.013 0.013 0.010 TESTES 1.527 1.813 1.773 1.713 1.596 2.331 1.410 1.666 1.559 1.391 1.678 1.695 1.623 1.781 1.613 1.773 1.691 1.840 1.790 EPIDID 0.345 0.435 0.491 0.384 0.344 0.454 0.333 0.382 0.393 0.348 0.361 0.408 0.396 0.398 0.411 0.392 0.446 0.402 0.469 PROSTATE 0.150 0.286 0.215 0.178 0.190 0.246 0.234 0.245 0.290 0.257 0.236 0.275 0.222 0.277 0.364 0.291 0.197 0.149 0.259 SEMINAL VESICLES 0.668 0.604 0.589 0.531 0.610 0.772 0.720 0.616 0.614 0.651 0.654 0.769 0.796 0.634 0.673 0.941 0.667 0.691 0.772 DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1399 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM MALE RATS GROUP : VII-1 - 1000 mg/kg ANIMAL NUMBER 670411 670415 670419 670423 670427 670431 670435 670439 670443 670448 670452 670456 670459 670463 670467 670471 670475 670479 670483 LIVER 8.735 11.127 6.045 11.946 9.273 9.039 8.717 9.754 8.450 8.781 9.736 8.498 9.113 8.383 9.519 10.433 10.233 9.297 9.275 THYROID GLAND 0.012 0.006 NW 0.018 .013 0.010 0.010 0.009 0.012 ' 0.007 0.007 0.009 0.009 0.012 0.017 0.011 0.008 0.011 0.012 TESTES 1.763 1.736 1.555 1.697 1.518 1.611 1.596 1.703 1.670 1.726 1.650 1.725 1.590 1.618 1.797 1.667 1.757 1.609 1.765 EPIDID 0.394 0.356 0.383 0.423 0.344 0.372 0.415 0.384 0.361 0.402 0.427 0.341 0.386 0.362 0.442 0.349 0.338 0.426 0.367 PROSTATE 0.275 0.205 0.212 0.331 0.205 0.201 0.240 0.173 0.231 0.166 0.197 0.246 0.215 0.224 0.296 0.193 0.227 0.219 0.262 SEMINAL VESICLES 0.697 0.470 0.526 0.914 0.677 0.543 0.643 0.633 0.702 0.580 0.725 0.572 0.545 0.597 0.893 0.519 0.588 0.815 0.749 ") DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1400 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : II-l - 0 mg/kg ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 FINAL BODY 195.4 235.0 276.9 254.0 231.6 223.3 261.6 293.9 244.4 267.0 245.9 233.6 237.5 212.0 256.0 226.5 226.5 246.4 226.5 LIVER 8.897 10.459 11.050 11.088 10.807 10.847 11.147 13.366 10.918 11.641 10.194 11.391 10.470 9.226 11.248 11.438 9.980 10.232 9.573 THYROID GLAND NW 0.015 0.017 0.015 0.016 0.015 0.013 0.015 0.012 0.018 0.018 0.016 0.012 0.021 0.018 0.014 0.018 0.017 0.014 UTERUS 0.355 0.368 0.414 0.455 0.574 0.421 0.364 0.372 0.431 0.355 0.409 0.352 0.573 0.343 0.572 0.935 0.339 0.686 0.696 BRAIN 1.570 1.666 1.912 1.874 1.865 1.829 1.992 1.912 1.766 1.862 1.712 1.843 1.857 1.758 1.824 1.732 1.797 1.849 1.747 Company Sanitized. Does not contain TSCA CBI - 1401 - F I ADULTS DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : IV-1 - 10 mg/kg ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 FINAL BODY 243.7 220.2 264.5 256.0 234.5 229.7 197.7 186.7 255.0 246.8 202.9 257.2 224.1 214.7 227.9 221.1 291.7 309.9 268.6 LIVER 11.356 9.817 10.764 12.503 10.308 9.707 7.946 7.419 12.506 '11.391 7.748 10.572 9.599 8.810 9.791 8.927 13.256 13.318 11.978 THYROID GLAND 0.015 0.017 0.019 0.016 0.021 0.014 0.024 0.015 0.021 0.022 0.020 0.019 0.023 0.016 0.023 0.018 0.020 0.014 0.013 UTERUS 0.540 0.397 0.488 0.470 0.337 0.392 0.374 0.844 0.376 0.396 0.699 0.513 0.479 0.548 0.848 0.367 0.327 0.374 0.494 BRAIN 1.810 1.712 1.837 1.843 1.860 1.872 1.662 1.615 1.854 1.839 1.743 1.989 1.785 1.802 1.820 1.945 1.838 1.781 1.844 Company Sanitized. Does not contain TSCA CBI -1402 - FI ADULTS DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VI-1 - 100 mg/kg ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 67.0657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 FINAL BODY 185.7 238.8 246.5 236.3 219.7 249.1 230.6 271.0 262.5 250.7 239.9 236.3 224.4 244.4 233.7 233.3 261.0 199.2 229.4 LIVER 7.912 11.086 10.123 9.299 8.466 10.999 8.815 10.846 11.700 10.134 10.823 11.513 9.508 9.967 9.662 10.563 10.054 8.604 10.542 THYROID GLAND 0.013 0.019 0.015 0.012 0.016 0.015 0.023 0.015 0.016 0.012 0.012 0.011 0.018 0.017 0.013 0.018 0.019 0.019 0.012 UTERUS 0.471 0.428 0.511 0.435 0.572 0.888 0.383 0.432 0.343 0.650 0.428 0.357 0.521 0.579 0.380 0.430 0.456 0.502 0.478 BRAIN 1.633 1.813 1.790 1.908 1.750 1.747 1.846 1.849 1.951 1.836 1.850 1.736 1.840 1.715 1.844 1.795 1.885 1'.753 1.714 Company Sanitized. Does not contain TSCA CBI - 1403 - FI ADULTS DuPont-11418 ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FINAL BODY AND ABSOLUTE ORGAN WEIGHTS (grams) FROM FEMALE RATS GROUP : VIII-1 - 1000 mg/kg ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 FINAL BODY 202.0 270.9 187.7 224.7 224.8 233.1 275.4 199.5 196.2 256.2 221.7 260.6 258.6 211.8 250.9 238.5 272.6 232.8 259.2 LIVER 9.153 11.875 8.340 9.890 9.566 8.597 10.788 8.261 8.650 ' 9.834 9.758 9.515 10.263 9.516 10.871 9.566 11.850 10.500 10.529 THYROID GLAND 0.015 0.016 0.017 0.018 0.014 0.017 0.025 0.019 0.016 0.015 0.011 0.023 0.012 0.011 0.019 0.013 0.015 0.015 0.014 UTERUS 0.502 0.738 0.454 0.645 0.442 0.701 0.955 0,353 0.341 0.442 0.513 0.458 0.383 0.406 0.497 0.457 0.601 0.400 0.513 BRAIN 1.746 1.862 1.688 1.784 1.747 1.746 1.772 1.744 1.716 1.888 1.745 1.981 1.800 1.786 1.698 1.895 1.870 1.702 1.842 Company Sanitized. Does not contain TSCA CBI - 1404 - ______________________________________________ DuPont-11418 - PI ADULTS H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : II-l - 0 mg/kg ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 67519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 LIVER 4.553 4.451 3.991 4.365 4.666 4.858 4.261 4.548 4.467 4.360 4.146 4.876 4.408 4.352 4.394 5.050 4.406 4.153 4.226 THYROID GLAND NW 0.006 0.006 0.006 0.007 0.007 0.005 0.005 0.005 0.007 0.007 0.007 0.005 0.010 0.007 0.006 0.008 0.007 0.006 UTERUS 0.182 0.157 0.150 0.179 0.248 0.189 0.139 0.127 0.176 0.133 0.166 0.151 0.241 0.162 0.223 0.413 0.150 0.278 0.307 BRAIN 0.803 0.709 0.691 0.738 0.805 0.819 0.761 0.651 0.723 0.697 0.696 0.789 0.782 0.829 0.712 0.765 0.793 0.750 0.771 FI ADULTS DuPont-11418 Company Sanitized. Does not contain TSCA C8I - 1405 - )> H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : IV-1 - 10 mg/kg ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 LIVER 4.660 4.458 4.070 4.884 4.396 4.226 4.019 3.974 4.904 4.615 3.819 4.110 4.283 4.103 4.296 4.038 4.544 4.298 4.459 THYROID GLAND 0.006 0.008 0.007 0.006 6.009 0.006 0.012 0.008 0.008 . 0.009 0.010 0.007 0.010 0.007 0.010 0.008 0.007 0.005 0.005 UTERUS 0.222 0.180 0.184 0.184 0.144 0.171 0.189 0.452 0.147 0.160 0.345 0.199 0.214 0.255 0.372 0.166 0.112 0.121 0.184 BRAIN 0.743 0.777 0.695 0.720 0.793 0.815 0.841 0.865 0.727 0.745 0.859 0.773 0.797 0.839 0.799 0.880 0.630 0.575 0.687 FI ADULTS DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1406 - )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : VI-X - 100 mg/kg ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 LIVER 4.261 4.642 4.107 3.935 3.853 4.415 3.823 4.002 4.457 4.042 4.511 4.872 4.237 4.078 4.134 4.528 3.852 4.319 4.595 THYROID GLAND 0.007 0.008 0.006 0.005 0.007 0.006 0.010 0.006 0.006 ' 0.005 0.005 0.005 0.008 0.007 0.006 0.008 0.007 0.010 0.005 UTERUS 0.254 0.179 0.207 0.184 0.260 0.356 0.166 0.159 0.131 0.259 0.178 0.151 0.232 0.237 0.163 0.184 0.175 0.252 0.208 BRAIN 0.879 0.759 0.726 0.807 0.797 0.701 0.801 0.682 0.743 0.732 0.771 0.735 0.820? 0.702 0.789 0.769 0.722 0.880 0.747 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1407 - >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS RELATIVE ORGAN WEIGHTS (% of body weight) FROM FEMALE RATS GROUP : VIII-1 - 1000 mg/kg ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 LIVER 4.531 4.384 4.443 4.401 4.255 3.688 3.917 4.141 4.409 3.838 4.401 3.651 3.969 4.493 4.333 4.011 4.347 4.510 4.062 THYROID GLAND 0.007 0.006 0.009 0.008 0.006 0.007 0.009 0.010 9.008 ' 0.006 0.005 0.009 0.005 0.005 0.008 0.005 0.006 0.006 0.005 UTERUS 0.249 0.272 0.242 0.287 0.197 0.301 0.347 0.177 0.174 0.173 0.231 0.176 0.148 0.192 0.198 0.192 0.220 0.172 0.198 BRAIN 0.864 0.687 0.899 0.794 0.777 0.749 0.643 0.874 0.875 0.737 0.787 0.760 0.696 0.843 0.677 0.795 0.686 0.731 0.711 Company Sanitized. Does not contain TSCA CBI - 1408 - ______________________________________________ DuPont-11418 - F I ADULTS ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations > ________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : II-l - 0 mg/kg ANIMAL NUMBER 670487 670491 670495 670499 670503 670507 670511 670515 670519 670523 670527 670530 670534 670538 670541 670545 670549 670553 670557 LIVER 5.667 6.278 5.779 5.917 5.795 5.931 5.596 6.991 6.182 6.252 5.954 6.181 5.638 5.248 6.167 6.604 5.554 5.534 5.480 THYROID GLAND NW 0.009 0.009 0.008 0.009 0.008 0.007 0.008 0.007 0.010 0.011 0.009 0.006 0.012 0.010 0.008 0.010 0.009 0.008 UTERUS 0.226 0.221 0.217 0.243 0.308 0.230 0.183 0.195 0.244 0.191 0.239 0.191 0.309 0.195 0.314 0.540 0.189 0.371 0.398 ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1409 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : i v - 1 - 10 mg/kg ANIMAL NUMBER 670562 670566 670570 670571 670575 670579 670583 670587 670591 670597 670601 670605 670609 670613 670617 670621 670625 670628 670632 LIVER 6.274 5.734 5.860 6.784 5.542 5.185 4.781 4.594 6.745 6.194 4.445 5.315 5.378 4.889 5.380 4.590 7.212 7.478 6.496 THYROID GLAND 0.008 0.010 0.010 0.009 0.011 0.007 0.014 0.009 0.011 ' 0.012 0.011 0.010 0.013 0.009 0.013 0.009 0.011 0.008 0.007 UTERUS 0.298 0.232 0.266 0.255 0.181 0.209 0.225 0.523 0.203 0.215 0.401 0.258 0.268 0.304 0.466 0.189 0.178 0.210 0.268 DuPont-11418 Company Sanitized. Does not contain TSCA O CD >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations _____________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP, : VI-1 - 100 mg/kg ANIMAL NUMBER 670636 670640 670644 670645 670649 670653 670657 670661 670662 670666 670670 670674 670679 670681 670685 670689 670693 670697 670701 LIVER 4.845 6.115 5.655 4.874 4.838 6.296 4.775 5.866 5.997 5.520 5.850 6.632 5.167 5.812 5.240 5.885 5.334 4.908 6.151 THYROID GLAND 0.008 0.010 Q.008 0.006 0.009 0.009 0.012 0.008 0.008 0.007 0.006 0.006 0.010 0.010 0.007 0.010 0.010 0.011 0.007 UTERUS 0.288 0.236 0.285 0.228 0.327 0.508 0.207 0.234 0.176 0.354 0.231 0.206 0.283 0.338 0.206 0.240 0.242 0.286 0.279 } DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1411 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS - FI ADULTS RELATIVE ORGAN WEIGHTS (organ to brain weight ratio) FROM FEMALE RATS GROUP : VIII-1 - 1000 mg/kg ANIMAL NUMBER 670705 670709 670713 670717 670721 670725 670729 670733 670737 670740 670744 670748 670751 670755 670759 670763 670767 670771 670775 LIVER 5.242 6.378 4.941 5.544 5.476 4.924 6.088 4.737 5.041 5.209 5.592 4.803 5.702 5.328 6.402 5.048 6.337 6.169 5.716 THYROID GLAND 0.009 0.009 0.010 0.010 0.008 0.010 0.014 0.011 0.009 0.008 0.006 0.012 0.007 0.006 0.011 0.007 0.008 0.009 0.008 UTERUS 0.288 0.396 0.269 0.362 0.253 0.401 0.539 0.202 0.199 0.234 0.294 0.231 0.213 0.227 0.293 0.241 0.321 0.235 0.279 DuPont-11418 Company Sanitized. Does not contain TSCA CBI 1412 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX OO INDIVIDUAL ANIMAL PATHOLOGY DATA - P, ADULTS - 1413Company Sanitized. Does not contain TSCA CBI )> H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations KEY TO APPENDIX INDIVIDUAL ANIMAL PATHOLOGY DATA MODE OF DEATH SD: SACRIFICED BY DESIGN SE: SACRIFICED IN EXTREMIS FD: FOUND DEAD AK: ACCIDENTLY KILLED (INCLUDES ANIMALS PRESENTED DEAD OR MORIBUND THAT HAVE INJURED THEMSELVES OR WERE INADVERTENTLY INJURED WHEN BEING HANDLED. IN-LIFE AND NECROPSY FINDINGS MAY BE USED TO MAKE THIS DETERMINATION. ) LESION GRADING HISTOPATHOLOGICAL CHANGES ARE DESCRIBED ACCORDING TO THEIR MORPHOLOGIC CHARACTER, DISTRIBUTION AND SEVERITY. THE DISTRIBUTION (EXTENT OF TISSUE INVOLVEMENT) IS INDICATED, WHERE APPROPRIATE, BY MODIFIERS SUCH AS FOCAL, MULTIFOCAL, DIFFUSE, UNILATERAL, BILATERAL, ETC.,- A SEVERITY SCORE, IF APPROPRIATE, IS ALSO ASSIGNED AS FOLLOWS: PRESENT: LESION PRESENT, SEVERITY NOT GRADED. MINIMAL : THE AMOUNT OF CHANGE PRESENT BARELY EXCEEDS THAT WHICH IS CONSIDERED TO BE WITHIN NORMAL LIMITS. MILD: IN GENERAL, THE LESION IS EASILY IDENTIFIED BUT OF LIMITED SEVERITY. THE LESION PROBABLY DOES NOT PRODUCE ANY FUNCTIONAL IMPAIRMENT. MODERATE : THE LESION IS PROMINENT BUT THERE IS SIGNIFICANT POTENTIAL FOR INCREASED SEVERITY. LIMITED TISSUE OR ORGAN DYSFUNCTION IS POSSIBLE. SEVERE : THE DEGREE OF CHANGE IS EITHER AS COMPLETE AS CONSIDERED POSSIBLE OR GREAT ENOUGH IN INTENSITY OR EXTENT TO EXPECT SIGNIFICANT TISSUE OR ORGAN DYSFUNCTION. COMMENT : GRADES MINIMAL THROUGH SEVERE REPRESENT PROGRESSIVE INVOLVEMENT/SEVERITY ALONG A CONTINUUM WITH MINIMAL LESIONS BEING THE LEAST SEVERE AND SEVERE LESIONS BEING THE MOST SEVERE. WHILE THE GRADES REFER TO THE MORPHOLOGICAL CHARACTERISTICS OF LESIONS, THEY ALSO INDICATE THEIR RELATIVE BIOLOGICAL SIGNIFICANCE. GROSS OBSERVATIONS LISTING MULTIPLE MASSES FOR A TISSUE ARE DISTINGUISHED WITH LETTERS (i.e., A, B, C, D, etc.) MICROSCOPIC CORRELATE (selected lesions) THE MICROSCOPIC CORRELATE FOR SELECTED GROSS OBSERVATIONS, PRIMARILY MASSES, IS PROVIDED TO THE RIGHT OF THE RESPECTIVE GROSS OBSERVATION. NEOPLASM DESIGNATIONS *B: BENIGN NEOPLASM, PRIMARY SITE *M: MALIGNANT NEOPLASM, PRIMARY SITE *X: MALIGNANT NEOPLASM, METASTATIC OR SECONDARY SITE ABBREVIATIONS NPT = NONPROTOCOL TISSUE NOS = NOT OTHERWISE SPECIFIED ) DuPont-11418 Company Sanitized. Does not contain TSCA o 03 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________ ____________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 664994 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1415- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 664996 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED t MICROSCOPIC OBSERVATIONS: NONE MICROSCOPIC CORRELATE (selected lesions): THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1416- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665000 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1417- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665005 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS,OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1418 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665012 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1419 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665021 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1420 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665029 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1421 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________ _____________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665040 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi -1422 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665044 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE yNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1423 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________ _____________ ______________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665046 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI -1424 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665069 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: PROSTATE - AGGREGATES, LYMPHOID, MINIMAL THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, COAGULATING GLANDS, EPIDIDYMIDES, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI -1425 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665075 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1426 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665079 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1427 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665087 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1428 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665091 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1429 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 66S104 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1430 - )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665135 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1431- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665141 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1432 - )) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ANIMAL #: 665144 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C8I - 1433 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: 1-0 DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665166 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO'ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not c o n ta in TSCA CBI - 1434 - )) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________ __________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ANIMAL #: 664997 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1435 - )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________________ ) DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ANIMAL #: 665001 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE t SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1436 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665006 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR. MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1437 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665017 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1438 - ) ') H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP; III-O DOSE; 10 mg/kg ) DuPont-11418 ANIMAL #: 665020 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: N O 1ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1439 - )) H-25425: Subchronic Toxicity 90-Day. Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665025 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1440 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665032 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1441 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665037 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1442- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665038 DAYS ON TEST: 113 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA O CD > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665041 DAYS ON TEST: 113 MODE OF DEATH: SD GROSSOBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1444- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665056 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1445 - )' ) > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ANIMAL #: 665058 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1446 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ANIMAL #: 665071 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1447 - )> H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Oae-Generation Reproduction Evaluations_____ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665110 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1448 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665113 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NONE MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE t THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1449- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA , MALE RATS GROUP: III-O DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665125 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1450 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665126 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC- EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1451 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665153 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: ' NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1452 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665163 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1453 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: III-O DOSE: 10 mg/kg ANIMAL #: 665167 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): ' MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1454 - )' ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________________ DuPont-11418 . INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ANIMAL #: 665003 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1455 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665004 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1456 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665034 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1457 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665036 DAYS ON TEST: 112 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1458 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665039 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1459 - >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations t INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg > DuPont-11418 ANIMAL #: 665051 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1460 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665055 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1461 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665066 DAYS ON TEST: 113 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1462 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665078 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1463 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665083 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1464 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665085 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1465 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665088 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1466 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665092 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: HO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1467 - )> H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665111 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1468 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665114 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : PROSTATE TESTES AGGREGATES, LYMPHOID, MINIMAL ONE OF PAIR NOT PRESENT THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI - 1469 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665116 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1470 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665124 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1471 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ANIMAL #: 665139 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO' ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1472 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665140 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1473 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: V-0 DOSE: 100 mg/kg ANIMAL #: 665147 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1474 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ) DuPont-11418 ANIMAL #: 664998 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1475 - ) >) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL #: 665011 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1476 - H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665018 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1477 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA , MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ) DuPont-11418 ANIMAL #: 665022 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1478 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665050 DAYS ON TEST: 89 MODE OF DEATH: FD GROSS OBSERVATIONS: SKIN WHOLE BODY ULCER/EROSION, HEAD; 7MM DIA AUTOLYSIS, ; MILD MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS : PROSTATE AGGREGATES, LYMPHOID, MILD THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLANDS, EPIDIDYMIDES, PITUITARY GLAND, SEMINAL VESICLES, TESTES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: THYROID GLAND SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: UNDETERMINED Company Sanitized. Does not contain TSCA CBI - 1479 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665057 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS : NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1480 - )) ) H -2 5 4 2 5 : Subchronic T o xic ity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL #: 665059 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING.TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi -1481 - H-25425: Subchronic T oxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL #: 665063 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1482 - ). > > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________ ____________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA ` MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL #: 665065 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1483 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL #: 665077 DAYS ON TEST: 113 MODE OF DEATH: SD DuPont-11418 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1484 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665090 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1485 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665093 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1486 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665102 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED? MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1487 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665105 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1488 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665109 DAYS ON TEST: 113 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1489 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665123 DAYS ON TEST: 112 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1490 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665133 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : TESTES ONE OF PAIR NOT PRESENT THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: COAGULATING GLAND, EPIDIDYMIDES, PROSTATE, SEMINAL VESICLES THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI - 1491 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665134 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE. SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1492 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665157 DAYS ON TEST: 112 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOEIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C8I - 1493 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA MALE RATS GROUP: VII-0 DOSE: 1000 mg/kg ANIMAL # : 665161 DAYS ON TEST: 111 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1494 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ANIMAL #: 665175 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1495 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665185 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI -1496 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665192 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1497 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ANIMAL #: 665198 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1498 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________ INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665203 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1499 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665206 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1500 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665220 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: , NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1501 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665226 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C8I - 1502 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665232 DAYS ON TEST: 123 MODE OF DEATH; SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1503 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665240 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1504 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665246 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1505 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ANIMAL #: 665249 DAYS ON TEST: 127 MODE OF DEATH: SD GROSS OBSERVATIONS: ' NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1506 - ') H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ) DuPont-11418 ANIMAL #: 665257 DAYS ON TEST: 132 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1507 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665264 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1508 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-0 DOSE: 0 mg /kg ANIMAL #: 665284 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1509 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665289 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: VAGINA - ESTRUS STAGE: METESTRUS THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI -1510- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665306 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION;. ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA C8I -1511 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg DuPont-11418 ANIMAL #: 665307 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI -1512- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ANIMAL #: 665334 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1513- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA ' FEMALE RATS GROUP: II-O DOSE: 0 mg/kg ANIMAL #: 665336 DAYS ON TEST: 131 MODE OF DEATH: SD GROSS OBSERVATIONS: LIVER - DISCOLORATION, TAN, LEFT, LOBE; 1MM DIA MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1514- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665180 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1515- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665181 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: ' NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1516- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665186 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1517- ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg ) DuPont-11418 ANIMAL #: 665187 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1518- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________ ____ __________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg ANIMAL #: 665205 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1519- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #-. 665210 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1520 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665212 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1521 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665244 DAYS ON TEST: 119 GROSS OBSERVATIONS: ` NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1522 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665248 DAYS ON TEST: 112 MODE OF DEATH: FD GROSS OBSERVATIONS: LIVER KIDNEYS SPLEEN THYMUS VAGINA LARGE, MINIMAL; SWOLLEN DISCOLORATION, TAN, MINIMAL, UNILATERAL, PELVIS LARGE, MILD EDEMA, MINIMAL FLUID, GREEN, THICK MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS :' PITUITARY GLAND - CYST, MINIMAL VAGINA - ESTRUS STAGE: PROESTRUS THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, THYROID GLAND, UTERUS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: UNDETERMINED Company Sanitized. Does not contain TSCA CBI - 1523 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg /kg DuPont-11418 ANIMAL #: 665253 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1524- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665258 DAYS ON TEST: 124 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1525 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665263 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOEIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1526 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665281 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1527 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665286 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1528 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________ INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665290 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY; NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 - 1529 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665292 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1530 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 ing/kg DuPont-11418 ANIMAL #: 665293 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: SKIN ALOPECIA, LEFT, INGUEN MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1531 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg/kg DuPont-11418 ANIMAL #: 665294 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1532 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg /kg DuPont-11418 ANIMAL #: 665329 DAYS ON TEST: 124 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBi - 1533 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations APPENDIX dd (Continued) INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: IV-0 DOSE: 10 mg /kg ) DuPont-11418 ANIMAL #: 665330 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTEP MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1534 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________ ______________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665173 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1535 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg /kg DuPont-11418 ANIMAL #: 665195 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO'ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1536 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg /kg ) DuPont-11418 ANIMAL #: 665207 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1537 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665217 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TJSSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1538 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665219 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED I MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1539 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665227 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1540 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation. Reproduction Evaluations____________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665243 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS- OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions) : MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1541 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665247 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1542 - ))) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665262 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTQLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1543 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 66526'? DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1544- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665272 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1545 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665273 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1546 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665274 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED,- MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBt - 1547 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665298 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: VAGINA ESTRUS STAGE: ESTRUS THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI - 1548 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665312 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1549 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665314 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: SKIN ALOPECIA, VENTRAL BODY MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1550 - ) ) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ANIMAL #: 665316 DAYS ON TEST: 129 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1551 - )) H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________ _______ INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665325 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY; NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI -1552 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg ) DuPont-11418 ANIMAL #: 665331 DAYS ON TEST: 123 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1553 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ) INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VI-0 DOSE: 100 mg/kg DuPont-11418 ANIMAL #: 665338 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1554 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665169 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS : NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1555 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________ ` INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665171 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1556 - )) > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ANIMAL #: 665191 DAYS ON TEST: 124 MODE OF DEATH: SD GROSS OBSERVATIONS: NO, ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1557 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665193 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1558 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ANIMAL #: 665213 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1559 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665214 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION:- NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1560 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665224 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS : NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: VAGINA ESTRUS STAGE: ESTRUS THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: OVARIES, UTERUS THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: OTHER SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE CAUSE OF DEATH/MORIBUND CONDITION: SACRIFICED BY DESIGN Company Sanitized. Does not contain TSCA CBI -1561 - )) H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ) DuPont-11418 ANIMAL #: 665231 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO' ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1562 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665245 DAYS ON TEST: 119 GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MODE OF DEATH: SD MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1563 - ) ' ) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg . ANIMAL #: 665254 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CB1 - 1564 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ANIMAL #: 665255 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1565 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665265 DAYS ON TEST: 122 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1566 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ANIMAL #: 665279 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1567 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #-. 665280 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1568 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665296 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1569 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 m g / k g DuPont-11418 ANIMAL #: 665315 DAYS ON TEST: 118 MODE OF DEATH: SD GROSS OBSERVATIONS: , NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1570 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Ohe-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000. mg/kg DuPont-11418 ANIMAL #: 665318 DAYS ON TEST: 121 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1571 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665320 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES NONE Company Sanitized. Does not contain TSCA CBI - 1572 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL PATHOLOGY DATA . FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg DuPont-11418 ANIMAL #: 665321 DAYS ON TEST: 119 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED MICROSCOPIC CORRELATE {selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MICROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1573 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL PATHOLOGY DATA FEMALE RATS GROUP: VIII-0 DOSE: 1000 mg/kg ANIMAL #: 665322 DAYS ON TEST: 120 MODE OF DEATH: SD GROSS OBSERVATIONS: NO ABNORMALITIES DETECTED . MICROSCOPIC CORRELATE (selected lesions): MICROSCOPIC OBSERVATIONS: NONE THE FOLLOWING TISSUES WERE UNREMARKABLE MICROSCOPICALLY: NONE THE FOLLOWING TISSUES WERE AUTOLYZED; DEGREE OF AUTOLYSIS DID NOT PRECLUDE MICROSCOPIC EXAMINATION: NONE THE FOLLOWING TISSUES WERE SEVERELY AUTOLYZED; MICROSCOPIC DIAGNOSES NOT MADE, ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE SECTIONS OF THE FOLLOWING TISSUES WERE NOT PRESENT FOR MICROSCOPIC EXAMINATION: NONE SECTIONS OF THE FOLLOWING TISSUES WERE INSUFFICIENT FOR MACROSCOPIC EXAMINATION; ORGAN NOT COUNTED IN INCIDENCE TABLES: NONE Company Sanitized. Does not contain TSCA CBI - 1574 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX PP INDIVIDUAL ANIMAL GROSS OBSERVATIONS - FI ADULTS - 1575 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations KEY TO APPENDIX INDIVIDUAL ANIMAL GROSS OBSERVATIONS - FI ADULTS MODE OF DEATH SD: SACRIFICED BY DESIGN DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH MALE RATS OBSERVATIONS GROUP: 1-1 DOSE: O mg/kg 670186 40 SD NO ABNORMALITIES DETECTED 670190 40 SD NO ABNORMALITIES DETECTED 670194 40 SD NO ABNORMALITIES DETECTED 670196 40 SD NO ABNORMALITIES DETECTED 670200 40 SD NO ABNORMALITIES DETECTED 670204 40 SD NO ABNORMALITIES DETECTED 670208 40 SD NO ABNORMALITIES DETECTED 670212 40 SD NO ABNORMALITIES DETECTED 670216 40 SD NO ABNORMALITIES DETECTED 670220 40 SD NO ABNORMALITIES DETECTED 670224 40 SD NO ABNORMALITIES DETECTED 670228 40 SD NO ABNORMALITIES DETECTED 670232 40 SD NO ABNORMALITIES DETECTED 670236 40 SD NO ABNORMALITIES DETECTED 670241 40 SD NO ABNORMALITIES DETECTED 670245 40 SD NO ABNORMALITIES DETECTED 670249 40 SD NO ABNORMALITIES DETECTED 670253 40 SD NO ABNORMALITIES DETECTED 670257 40 SD NO ABNORMALITIES DETECTED - 1577 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH MALE RATS OBSERVATIONS GROUP: III-l DOSE: 10 mg/kg 670261 40 SD NO ABNORMALITIES DETECTED 670265 40 SD NO ABNORMALITIES DETECTED 670269 40 SD NO ABNORMALITIES DETECTED 670271 40 SD NO ABNORMALITIES DETECTED 670275 40 SD NO ABNORMALITIES DETECTED 670279 40 SD NO ABNORMALITIES DETECTED 670283 40 SD NO ABNORMALITIES DETECTED 670287 40 SD NO ABNORMALITIES DETECTED 670291 40 SD NO ABNORMALITIES DETECTED 670295 40 SD NO ABNORMALITIES DETECTED 670299 40 SD NO ABNORMALITIES DETECTED 670303 40 SD NO ABNORMALITIES DETECTED 670307 40 SD NO ABNORMALITIES DETECTED 670311 40 SD NO ABNORMALITIES DETECTED 670315 40 SD NO ABNORMALITIES DETECTED 670319 40 SD NO ABNORMALITIES DETECTED 670323 40 SD NO ABNORMALITIES DETECTED 670328 40 SD NO ABNORMALITIES DETECTED 670331 40 SD < NO ABNORMALITIES DETECTED - 1578 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH MALE RATS OBSERVATIONS GROUP: V-l DOSE: 100 mg/kg 670335 40 SD NO ABNORMALITIES DETECTED 670339 40 SD NO ABNORMALITIES DETECTED 670340 40 SD NO ABNORMALITIES DETECTED 670347 40 SD NO ABNORMALITIES DETECTED 670351 40 SD NO ABNORMALITIES DETECTED 670355 40 SD NO ABNORMALITIES DETECTED 670359 40 SD MESENTERY - DISCOLORATION, RED; NECROTIC FAT, 5MM DIA 670363 40 SD NO ABNORMALITIES DETECTED 670367 40 SD NO ABNORMALITIES DETECTED 670371 40 SD NO ABNORMALITIES DETECTED 670375 40 SD NO ABNORMALITIES DETECTED 670379 40 SD NO ABNORMALITIES DETECTED 670382 40 SD NO ABNORMALITIES DETECTED 670387 40 SD NO ABNORMALITIES DETECTED 670391 40 SD NO ABNORMALITIES DETECTED 670395 40 SD NO ABNORMALITIES DETECTED 670399 40 SD NO ABNORMALITIES DETECTED 670403 40 SD NO ABNORMALITIES DETECTED 670407 40 SD NO ABNORMALITIES DETECTED - 1579 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH MALE RATS GROUP: VII-1 OBSERVATIONS DOSE: 1000 mg/kg 670411 40 SD NO ABNORMALITIES DETECTED 670415 40 SD NO ABNORMALITIES DETECTED 670419 40 SD THYROID NOT PRESENT AT WEIGHING NO ABNORMALITIES DETECTED 670423 40 SD NO ABNORMALITIES DETECTED 670427 40 SD NO ABNORMALITIES DETECTED 670431 40 SD NO ABNORMALITIES DETECTED 670435 40 SD NO ABNORMALITIES DETECTED 6704.39 40 SD KIDNEYS - DILATATION, RIGHT, PELVIS 670443 40 SD NO ABNORMALITIES DETECTED 670448 40 SD NO ABNORMALITIES DETECTED 670452 40 SD NO ABNORMALITIES DETECTED 670456 40 SD NO ABNORMALITIES DETECTED 670459 40 SD NO ABNORMALITIES DETECTED 670463 40 SD NO ABNORMALITIES DETECTED 670467 670471 40 SD 40 SD KIDNEYS - DILATATION, MILD, RIGHT, PELVIS 4 NO ABNORMALITIES DETECTED 670475 40 SD NO ABNORMALITIES DETECTED 670479 40 SD NO ABNORMALITIES DETECTED 670483 40 SD NO ABNORMALITIES DETECTED - 1580 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH FEMALE RATS OBSERVATIONS GROUP: II-l DOSE: 0 mg/kg 670487 670491 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670495 40 SD NO ABNORMALITIES DETECTED 670499 40 SD NO ABNORMALITIES DETECTED 670503 40 SD NO ABNORMALITIES DETECTED 670507 40 SD NO ABNORMALITIES DETECTED 670511 40 SD NO ABNORMALITIES DETECTED 670515 40 SD NO ABNORMALITIES DETECTED 670519 40 SD NO ABNORMALITIES DETECTED 670523 40 SD NO ABNORMALITIES DETECTED 670527 40 SD NO ABNORMALITIES DETECTED 670530 40 SD NO ABNORMALITIES DETECTED 670534 40 SD NO ABNORMALITIES DETECTED 670538 40 SD NO ABNORMALITIES DETECTED 670541 40 SD NO ABNORMALITIES DETECTED 670545 40 SD NO ABNORMALITIES DETECTED 670549 40 SD NO ABNORMALITIES DETECTED 670553 40 SD NO ABNORMALITIES DETECTED 670557 40 SD NO ABNORMALITIES DETECTED -1581 - DuPont-11418 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH FEMALE RATS OBSERVATIONS GROUP: IV-1 DOSE: 10 mg/kg 670562 670566 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670570 40 SD NO ABNORMALITIES DETECTED 670571 40 SD NO ABNORMALITIES DETECTED 670575 670579 40 SD 40 SD NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670583 40 SD NO ABNORMALITIES DETECTED 6705.87 40 SD NO ABNORMALITIES DETECTED 670591 40 SD NO ABNORMALITIES DETECTED 670597 40 SD NO ABNORMALITIES DETECTED 670601 40 SD NO ABNORMALITIES DETECTED 670605 40 SD NO ABNORMALITIES DETECTED 670609 40 SD NO ABNORMALITIES DETECTED 670613 40 SD NO ABNORMALITIES DETECTED 670617 40 SD NO ABNORMALITIES DETECTED 670621 40 SD NO ABNORMALITIES DETECTED 670625 40 SD NO ABNORMALITIES DETECTED 670628 40 SD NO ABNORMALITIES DETECTED 670632 40 SD NO ABNORMALITIES DETECTED - 1582 - DuPont-11418 > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ DuPont-11418 INDIVIDUAL ANIMAL GROSS OBSERVATIONS ANIMAL DAYS MODE OF NUMBER ON TEST DEATH FEMALE RATS OBSERVATIONS GROUP: VI-1 DOSE: 100 mg/kg 670636 40 SD NO ABNORMALITIES DETECTED 670640 40 SD NO ABNORMALITIES DETECTED 670644 40 SD NO ABNORMALITIES DETECTED 670645 40 SD NO ABNORMALITIES DETECTED 670649 40 SD NO ABNORMALITIES DETECTED 670653 40 SD NO ABNORMALITIES DETECTED 670657 40 SD NO ABNORMALITIES DETECTED 670661 40 SD NO ABNORMALITIES DETECTED 670662 40 SD NO ABNORMALITIES DETECTED 670666 40 SD NO ABNORMALITIES DETECTED 670670 40 SD NO ABNORMALITIES DETECTED 670674 40 SD NO ABNORMALITIES DETECTED 670679 40 SD NO ABNORMALITIES DETECTED 670681 40 SD NO ABNORMALITIES DETECTED 670685 40 SD NO ABNORMALITIES DETECTED 670689 40 SD NO ABNORMALITIES DETECTED 670693 40 SD NO ABNORMALITIES DETECTED 670697 40 SD NO ABNORMALITIES DETECTED 670701 40 SD NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI - 1583 - Company Sanitized. Does not contain TSCA CBI ) H-25425. Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Gensraon Reproduction Evaluation INDIVIDUAL ANIMAL GROSS OBSERVATIONS m i m i d a y s MODE OF NUMBER ON TEST DEATH FEMBJUK RATS OBSERVATIONS GROUP: VIII-1 DOSE: 1000 mg/kg 670705 40 SD NO ABNORMALITIES DETECTED 670709 40 SD NO ABNORMALITIES DETECTED 670713 40 SD NO ABNORMALITIES DETECTED' 670717 40 SD NO ABNORMALITIES DETECTED 670721 40 SD NO ABNORMALITIES DETECTED 670725 40 SD NO ABNORMALITIES DETECTED 670729 40 SD NO ABNORMALITIES DETECTED 670733 40 SD NO ABNORMALITIES DETECTED 670737 40 SD NO ABNORMALITIES DETECTED 670740 40 SD NO ABNORMALITIES DETECTED 670744 40 SD NO ABNORMALITIES DETECTED 670748 40 SD NO ABNORMALITIES DETECTED 670751 40 SD NO ABNORMALITIES DETECTED 670755 40 SD NO ABNORMALITIES DETECTED 670759 40 SD NO ABNORMALITIES DETECTED 670763 40 SD NO ABNORMALITIES DETECTED 670767 40 SD NO ABNORMALITIES DETECTED 670771 40 SD NO ABNORMALITIES DETECTED 670775 40 SD NO ABNORMALITIES DETECTED - 1584 - DuPont-11418 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX QQ INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS - 1585 Company Sanitized. Does not contain TSCA CBI )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________________ KEY TO APPENDIX INDIVIDUAL ANIMAL GROSS OBSERVATIONS - FI PUPS AND WEANLINGS NOTE TEST DAY 1 = POSTNATAL DAY 21 MODE OF DEATH SP: SACRIFICED BY DESIGN FD: FOUND DEAD ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1586- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: II-O DOSE: 0 mg/kg OBSERVATIONS 665220 M 670187 670188 670189 F 670488 670489 670490 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665334 M 670191 670192 670193 F 670492 670493 670494 1 SP 1 SP 1 SP 1 SP ' 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665257 M 670195 F 670496 670497 670498 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665175 M 670198 670197 670199 F 670500 670501 670502 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665336 M 670201 670202 670203 F 670504 670505 670506 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED WHOLE BODY - SMALL NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain fSCA CBI - 1587 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION PI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: II-O DOSE: 0 mg/kg OBSERVATIONS 665192 M 670205 670206 670207 F 670508 670509 670510 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665232 M 670209 670210 670211 F 670512 670513 670514 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665307 M 670213 670214 670215 F 670516 670517 670518 1 SP i SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665246 M 670217 670218 670219 F 670520 670521 670522 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665264 M 670221 670222 670223 F 670524 670525 670526 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA C8I - 1588 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________DuPont-11418 DAM ANIMAL NUMBER 665185 PUP SEX M F 665206 M F 665306 M F 665226 M ,F 665198 M F INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS PUP ANIMAL DAYS NUMBER ON TEST FATE DAM GROUP: II-O DOSE: 0 mg/kg OBSERVATIONS 670225 670226 670227 670528 670529 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670229 670230 670231 670531 670532 670533 1 SP 1 SP 1 SP 1 SP - 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670233 670234 670235 670535 670536 670537 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670237 670238 670239 670240 670539 670540 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670242 670243 670244 670542 670543 670544 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI - 1589 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: II-O DOSE: 0 mg/kg OBSERVATIONS 665249 M 670246 670247 670248 F 670546 670547 670548 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665284 M 670250 670251 670252 F 670550 670551 670552 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, RIGHT, PELVIS 665240 M 670254 670255 670256 F 670554 670555 670556 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665203 M 670258 670259 F 670558 670559 670560 670561 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1590 - > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________ _________________________ DuPont-11418 DAM . ANIMAL PUP NUMBER SEX 665212 M F 665180 M F 665292 665187 M M F 665205 M F INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS PUP ANIMAL DAYS NUMBER ON TEST FATE DAM GROUP: IV-0 DOSE: 10 mg/kg OBSERVATIONS 670262 670263 670264 670563 670564 670565 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670144 670145 670266 670267 670268 670567 670568 670569 -21 FD -2 ; FD 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670270 1 SP NO ABNORMALITIES DETECTED 670272 670273 670274 670572 670573 670574 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670276 670277 670278 670168 670576 670577 670578 1 SP 1 SP 1 SP -21 FD 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI - 1591 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TST FATE DAM GROUP: IV-0 DOSE: 10 mg/kg OBSERVATIONS 665263 M 670280 670281 670282 F 670580 670581 670582 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665210 M 670284 670285 670286 F 670584 670585 670586 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665181 M 670288 670289 670290 F 670588 670589 670590 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665248 M 670146 -21 FD 670147 670148 670149 -21 FD -21 FD -21 FD ` 665293 M 670292 F 670592 670593 670594 670595 670596 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED WHOLE BODY - AUTOLYSIS WHOLE BODY - AUTOLYSIS STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1592 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: IV-0 DOSE: 10 mg/kg OBSERVATIONS 665329 M 670296 670297 670298 F 670598 670599 670600 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 66529p M 670300 670301 670302 F 670602 670603 670604 1 SP 1 SP 1 SP 1 SP ' 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665253 M 670304 670305 670306 F 670606 670607 670608 4 SP l SP l SP l SP l SP l SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665286 M 670308 670309 670310 F 670610 670611 670612 l SP l SP l SP l SP l SP l SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665281 M 670312 670313 670314 F 670614 670615 670616 l SP l SP l SP l SP l SP l SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1593 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: IV-0 DOSE: 10 mg/kg OBSERVATIONS 665186 M 670316 670317 670318 F 670618 670619 670620 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665330 M 670322 670320 670321 F 670622 670623 670624 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665294 M 670324 670325 670326 670327 F 670626 670627 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665244 M 670329 670330 F 670629 670630 670631 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665258 M 670332 670333 670334 F 670633 670634 670635 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1594 - Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION Fl PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VI-0 DOSE: 100 mg/kg OBSERVATIONS 665338 M 670336 1 SP 670337 1 SP F 670174 -21 FD 670175 670637 670638 -12 FD 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED SKULL - HEMORRHAGE, CRANIA NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665219 F 670641 670642 670643 1 SP 1 SP ' 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665267 M 670341 670342 670343 670344 670345 670346 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665325 F 670646 670647 670648 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665331 M 670352 670353 670354 F 670650 670651 670652 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665217 M 670150 -21 FD 670356 1 SP 670357 1 SP 670358 1 SP F 670654 1 SP 670655 1 SP 670656 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED - 1595 - DuPont-1141S Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VI-0 DOSE: 100 mg/kg OBSERVATIONS 665227 M 670360 670361 F 670658 670659 670660 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665262 M 670364 670365 670366 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665247 M 670368 670369 670370 F 670663 670664 670665 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665243 M 670372 670373 670374 F 670667 670668 670669 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665312. M 665207 F M F 670376 670377 670378 670671 670672 670673 670380 670381 670675 670676 670677 670678 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP KIDNEYS - DILATATION, RIGE NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED PELVIS - 1596 - DuPont-11418 11-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAY NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VI-0 DOSE: 100 mg/kg OBSERVATIONS 665273 M F 670383 670384 670385 670386 670680 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665274 M 670388 670389 670390 F 670682 670683 670684 1 SP 1 SP 1 SP 1 SP 1 SP ' 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665272 M 670392 670393 670394 F 670686 670687 670688 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665195 M 670396 670397 670398 F 670690 670691 670692 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665314 M 670400 670401 670402 F 670694 670695 670696 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1597 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION PI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VI-0 DOSE: 100 mg/kg OBSERVATIONS 665316 M 670404 670405 670406 F 670698 670699 670700 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665173 M 670408 670409 670410 F 670702 670703 670704 1 SP 1 SP 1 SP 1 SP '1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA C8I - 1598 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ DuPont-11418 INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VIII-0 DOSE: 1000 mg/kg OBSERVATIONS 665296 M 670412 670413 670414 F 670706 670707 670708 1 SP 1 SP I SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665193 M 670416 670417 670418 F 670710 670711 670712 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665320 M 670420 670421 670422 F 670714 670715 670716 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DEFECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665315 M 670424 670425 670426 F 670180 670718 670719 670720 1 SP 1 SP 1 SP -21 FD 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665318 M 670428 670429 670430 F 670722 670723 670724 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA C8I - 1599 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ ________ DuPont-11418 DAM ANIMAL NUMBER 665279 PUP SEX M F 665254 M F 665245 M F 665322 M F 665214 M F INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS PUP ANIMAL DAYS NUMBER ON TEST FATE DAM GROUP: VIII-0 DOSE: 1000 mg/kg OBSERVATIONS 670156 -21 FD 670432 670433 670434 670726 670727 670728 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP STOMACH - NO MILK SPOT LUNGS - NOT EXPANDED WHOLE BODY - SMALL NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670436 670437 670438 670730 670731 670732 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670440 670441 670442 670734 670735 670736 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670444 670445 670446 670447 670738 670739 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 670449 670450 670451 670741 670742 670743 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED Company Sanitized. Does not contain TSCA CBI - 1600 - ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______________________________________ INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VIII-0 DOSE: 1000 m g / k g OBSERVATIONS 665321 M 670453 670454 670455 F 670745 670746 670747 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665171 M 670457 670458 F 670749 670750 1 SP SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665265 M 670460 670461 670462 F 670752 670753 670754 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665169 M 670464 670465 670466 F 670756 670757 670758 1 SP 1 SP 1 SP 1 SP 1 SP 1 .SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED KIDNEYS - DILATATION, BILATERAL, NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665191 M 670468 670469 670470 F 670760 670761 670762 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED ) DuPont-11418 Company Sanitized. Does not contain TSCA CBI -1601 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL GROSS OBSERVATIONS IN GENERATION FI PUPS AND WEANLINGS . DAM PUP ANIMAL PUP ANIMAL DAYS NUMBER SEX NUMBER ON TEST FATE DAM GROUP: VIII-0 DOSE: 1000 mg/kg OBSERVATIONS 665231 M 670472 670473 670474 F 670764 670765 670766 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665255 M 670476 670477 670478 F 670768 670769 670770 1 SP 1 SP 1 SP ' 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665213 M 670480 670481 670482 F 670772 670773 670774 1 SP 1 SP 1 SP 1 SP 1 SP 1 SP NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED NO ABNORMALITIES DETECTED 665280 M 670157 -21 FD WHOLE BODY - AUTOLYSIS 670484 1 SP . NO ABNORMALITIES DETECTED 670485 1 SP NO ABNORMALITIES DETECTED 670486 1 SP NO ABNORMALITIES DETECTED F 670776 1 SP NO ABNORMALITIES DETECTED 670777 1 SP NO ABNORMALITIES DETECTED 670778 1 SP NO ABNORMALITIES DETECTED DuPont-11418 Company Sanitized. Does not contain TSCA CBI - 1602 -
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