Document 7Me8zxNBjL6d8KwBOm9p0Zzq8
A AR226-2876
Copies to:
E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine
33 HASKELL LABORATORY REPORT NO. 52-79 3
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. Material Tested n'
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Haskell No. 12,402
Other Codes
Sample Ready
for Testing
7/6/78
Material Submitted by
Chemicals, Dyes & Pigments Dept. Jackson Laboratory
3O** Chamber Works
oo3 TEN-DOSE ORAL. SUBACUTE TEST
25'.
HI.
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The test a^e5ia1' 88 8 50% suspension io acefcpne/cprn oil 15:5 or 7.5:92.5, was administered by intragastric intubation to a group of 10 young adult ChR-CD male >sats at a repeated dosage level of 3,400 mg/kg/day; an additional
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group of 10 rats served as controls and Was intubated with acetone/corn oil 15:85 or 7.5:92.5. Eight test rats died before the fifth dose and the remaining two test rats Were sacrificed the day after the fourth dose. Two control rats
were sacrificed after the fourth dose. Four of the remaining eight controls ware sacrificed after the tenth dose and the
remaining four were sacrificed after a 14-day! recovery period. **
o in8t B8teria} a? an 18Z suspension in acetone/corn oil 15:85, was administered by intragastric intubation to a
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f-10 y?Un?
Ch CD 0,818 ratS 8t 8 rePeated dsage level of 1,700 mg/kg/day; an additional group of 10 rats
r a d e r e sacrf^J*1'e?" *"tubated acetone/corn oil 15:85. Ten test rats died before the sixth dose. Two control
3 - . ificed after the seventh dose and the remaining eight controls were sacrificed without pathology.***
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2. ground! ioSL ra!-eriai:
S"8penelon tn scetone/com oil 15:85, was administered by intragastric intubation to a
anma."
served as
ChRTCD "*le TMtsi at a repeated dosage level of 850 mg/kg/day; an additional group of 10 rats
of ihe regnino ! / 11?
lntubated with acetone/corn oil 15:85. Four test rats died before the tenth dose and three
o<a>o
recovery
test rat8 were sacrificed approximately four hours after the tenth dose, and three after a 14-day
after a 14-day recoveryCperlod
Were 8acrificed after the tenth dose and the remaining five controls were sacrificed
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Company Sanitized. Does not contain TSCA CB3
^WMMiMMayft
Resu. Dose
(mg/kg/dav) 3,400
1,700
850
No. of Doses
2-4
3-5
3-10
(
Mortality 8/10
10/10
4/10
First Meek:
Clinical Signs
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*
SCA1R6Q f&Cfit (Jlfle
lacrimation, prostration, and weight loss.
First Week:
llV,Bpad P8ture* congestion stained fac. d wet perineal area, weakness, and weight loss.
First Week:
lacrimation, weakness. h - ^ 'p S E L T j g h T ^ .
Second Week: weightless
^ . h u m p e d posture, weakness, stained ' 6d faCE* eyeS wlf-closed, and
-- R eco ve ry -P e rio d : Wnno---------- ---- -- --------- --------- ------ ---- ---------- ---- -----------------
Pathologic Chaoflea:**** See Append!, (Pathology gapnrt Ho. 2-79>.t
m o tta lltla s war. obatoerv4edd .iionKe'illlT O ,,0" " ! : ,l;!L8^ L'1?S;h;o,f,?S-"?* "
- > [ 0 tto. 1. 0t da,,ai sn)t.e dS^er ^ a 2 h t ,,1,, . S S
SaprleaVo.Sth*y*nu?a, atexnal bone nar*row ,^ e.pyldrldSynliay tSoatdes *ranal*-r?hBl 0W.*iV*^*s*' *.*"* luhndgnaa,togpaoeitartolclnctoeal ltl.nwalart.rMa ct, liv er '
ere confined to the liver (with 1 tat alao S n r ,, ; M c 1 t S ^ 0`*'
" 6"g
* * * * * * * 8 5 *
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H-12,402
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and
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12.403.
12. 1, 6.
Company Sanitized. Does not contain TSCA
ere will be a supplemental pathology report for the 3 ion .,,'v
,
P or the 3,400 mg,kg/day dose level animals when histology is collate.
V a*81"""
Company Sanitized. Does not contain TSCA CBt
Company Sanitized. Does not contain TSCA CB
Report by:
Approved by:
LH:vlm Pate Issued: March 16. 1979
aport No. 52-79
m
-3
Lonnie Himckle Technician
Gerald~t. Kennedy Chief, Acute Investigations
