Document 726OE26RxYexGLp2X3bpOVLE

9iv&M/uxjJ 310 -TEST Jlakyioi&iusA, 9nc. 1810 FRONTAGE ROAD NORTHBROOK, ILLINOIS 60062 September 23, 1975 Dr. Milton Ereifield Project Manager, Vinyl Chloride Research Manufacturing Chemists Association 1 323 Connecticut Avenue, Washington, D. C. 20009 Dear Mr. Freifield: Re: IB T No. 663-03222 - Chronic Vapor Inhalati on Toxicity Study with Vinyl Chloride (Ethylene Derived) in Albino Rats, Albino Mice and Golden Hamsters We are submitting herewith our laboratory report prepared in connection with the above study. Very truly yours. JCC:bp J. C. Calandra President CUSAROSS 01189 !)3 I O * i E S i JtaJj&uilcy'l&i., ;kc. 23-MONTH STATUS SUMMARY TO MANUFACTURING CHEMISTS ASSOCIATION CHRONIC VAPOR INHALATION TOXICITY STUDY WITH VINYL CHLORIDE (ETHYLENE DERIVED) IN ALBINO RATS, ALBINO MICE AND GOLDEN HAMSTERS SEPTEMBER 23, 1975 13T NO. 663-03222 I. Introduction A chronic vapor inhalation toxicity study with Vinyl Chloride (Ethylene Derived) was initiated on September 10, 1973, and termi nated on September 10, 1974. Animals were then placed on observa tion. A summary of all data obtained through the twenty-third month is reported herein. CUSAROSS 01190 3 1 O T S T Jiau&iatani&ir, -> II. Summary Exposure of mice to Vinyl Chloride was terminated after 9 months of testing. At this time all surviving mice were placed under observation for the remainder of the investigation with the exception of the T~HI group (2,500 ppm) which was sacrificed during the eleventh month. Rats and hamsters were exposed to Vinyl Chloride for 12 months before being placed under a non-treated observation period. Respectfully submitted, INDUSTRIAL BIO-TEST LABORATORIES, INC. Report prepared by: Dennis C. Lindberg, 3.S. Assistant to the Manager Decatur Research Laboratories Report approved by: /ojin W. Goode , Ph . D . Stlanager Decatur Research Laboratories Toxicology M. L. Keolinger^ Ph.Ek/ Manager, Toxicology Dg CUSAROSS 01191 BIO-TEST ^aJtosvzt&'ued', Doc. 3 III. Body Weight Data The mean body weight data for albino rats, albino mice and hamsters are presented in Tables I, II and III, respectively. CUSAROSS 01192 TAHI.fi: I IK M A'l'KUl Ah; Vinyl Chlm i.U- (Uhyk.u- IK CImomU. V*i|>oi- Ijili.ilckhun Tuxkily Study Albiuu Hals, Alhimi Muc mii.1 t.likh II........iw* Silinm.My mf Milan Hml y Wciyhlsi - Athino Ihii* Mih inn.nli ( ll Ull^l lit: T1 t II tm tit: 11 i it T III T IV Mi'an Hotly (^iamx) Mouth timtihcr; 0 i l- - 3 . i.. 5 6 _7__ _JL 7__ _iii_ N _J 2__ n M _ IS 16 l / id IV _ 20_ 21 ll __2_3 205 363 456 14H 51/ 517 541 55U 55') 677 677 0H4 642 t (id 7 37 (67 /H2 (n 7rt i 0J 812 823 777 till tm i IK i m -m 526 545 SSI 561 5')) (.51 6 i t) 670 676 704 732 754 /OS t / t 784 74B 788 771 766 760 in I tf.O IS/ -rju 444 567 565 5H5 6B1 66 J 676 7 36 71(1 764 7H0 77'| / M 1 ?b i 781 717 - 2no 1*) 1 1 Si 444 527 son 567 576 5BI 02/ 627 6UU /Id 727 761 76(1 /su - - ---- Oiati[;t: 6U4 551 - 1 Ml 2J5 275 244 ns j.:u 320 HI 356 m 366 3U0 37(1 37 7 421 hi 16 1 1 /S IV i 511 527 520 527 557 II.M t U lt\ 277 i 10 joh 12J 148 J6 / 157 30 i 37 4 }H1 375 425 lid 15(1 t ./ 172 18') 143 507 400 4B4 v>sI/I in 2H4 10-E il 1 HI. 129 Ml J SB ibll 361 3R6 414 441 4 77 462 1 10 450 18 1 444 -- 167 1'10 2tl7 30 3 11 / \l\ 327 J46 J5`) 354 156 371 178 420 ISO -- -- -- 377 316 - MU 25 \ 2K2 ^dit 241 IM 324 JIB lit! J6J 36 J 3H1 NA 3 75 NA 37 3 42 1 - --- - ... ... . _ _--...... ______ ____ __ ___ ______ _____ _____ _... - _ __ _ . ____ ___ __ ___________ - fit. uiuir animals i < 4iulnl(i|' Mi NA 16.1 avatlal.l, imji S s I C C r t K n ci C/7 > ?o O C/3 C/3 o vD Sc Jt M,.k l-'eiii.ib (il <}ll|i m; T1 i it rm m; T1 1 II T 111 t Alll I il Tl-hT MA'J LlllAL. Viuyl Clilcnblc (bliiylune D^rivi-il) Chronic Vitjmr Inluil^lton Tumidly Slvitly * Albino Kilsi, Albino Mice amT li.Mun Handlers .............. ny of Mcjii llutly Wc-l|jlHcj - Albino Mice M* .in lUttly W ,-iyl.l^ Jill s } - --- _ -- ---------------- -- Month Numbe 0 \ 2 i 'J s (, 7 d j JO 1 J 11 11 H IS lb 1 I IM in 20 21 22 23 IS 10 11 i i 1b i j 4b S2 V) IV 1J 47 4W 17 IS 4 b 4 3 i i 41 - --- n VJ 11 H AZ 47 IS 4 7 47 1b 41) lb id SO 10 - -- - ib to m 1 1 t^ IS n 41 4 b 37 41 IS - - ib 10 U It sh is 41 ii 4 1 31 - ' -- --- - - /'} \z i t IS lb Vi IK 37 41 40 37 10 40 10 41 \z III JO V) 30 3`i 41 31 41 ui H j j IV jo 111 10 41 in 40 12 13 M 41 41 3`J U5 - - - - - /H H 11 IS a lb Jb lb 40 3') ID 40 3 J lb 40 1U lb -- --- ZH n i1 IS u> J7 IV 34 3? 31 11 ' - - '* - \Z - - - Nn OkOI L* -*llilll.ilii I i III .lilt k 111 ^ 111 I 0 C n u I O a 03 > o 03 03 O ui vO 1 S3 X" O I 8 l jMU.M 111 IhSI MAJJ'KlAl.. Vinyl Cl.lmith- (Ul.ylonc Duivnl) Si x M.ilt Cu Ull^l in: ri T 11 r in axiom*. V.Ii|jiji inili.ii.ititm J oxicily Slmly - A11>I no Jt u l *>, Altnno Mu L .1 11 C 1 ......1 .. in U- ' Smimm f y of Mi'.iil Hotly sVf 11 kt ix* (ml linn II j 11 Oj 11 ------- -- - " -- -- Mcdii Hotly W "(6,'Olllb ) - -' ----- - -- ------------- -- Mouth NuiiiHcr, 7 J i _ j>_ i. 7 b 9 JO _ l l___ J _J 1 __ 11 15 16 ' in 19 io 21_ 22 23 Clun^i: jj 9B 1 UJ UO 129 no liJ 1 Ul hb 1 It 129 i.'{. 125 1 n ms 125 J2f. 1 1 l 1 JO HI m 1 10 143 HI, n 'JO 101 m UtJ 121 i n 12H 121. IIU 115 no m 121 121 122 125 1 i M 1 u 116 116 117 HI 15!) t> i 0 V 74 99 119 mu no 1 IH 122 II7 115 115 121 126 ni 129 l Hi 1 \ \ Ul 111 111 - _ 60 a/ VI 9J 91 an 1 u 11(1 IJ5 m 115 IM no 12 J 120 129 129 1 Ul Ml 116 -- 73 79 - JVnmU - lie T1 i it j ai It JIM IIIH 1 Irt 1X0 11 \ 121 125 MS in 1 19 116 117 115 Ml 1 19 IIS l '0 i in 112 121 tti 75 III/ 112 1 III i in 122 1 JO 126 125 111! no MU 115 1 L7 121 1 tl M'5 Ul 111 126 M 74 7V tun 11)7 mi. m ni lib 1 IB 112 112 107 IM no 117 122 1/6 122 I2B 127 69 UX ion Jll< Jot, 1 U4 IIU i in 105 107 1117 77 JUt 105 109 112 76 --- -- -- . -- -- ------ --___ ___ _-- . - - ._ - - _ --- - .. . - - _ _______ - IVn mm I- aU11^ik.iII i hi.tilling in j^lnUp, I r 0" O & DHcLtiitiaL 3 I O - T E S T J?cuu>ia&yue, Due. 7 IV. Mortality Data The cumulative monthly mortality data are presented in Tables IV through VI. The following is a summary of remaining animal groups: Soecies Sex Groups Remaining Rats Male Female UC, T-I UC, T-I Mice Female UC Hamsters 1 Gle U C ~ -T From mortality data of the past months of observation, the following estimations of death wer e obtained: Species Group and Sex Estimated Time of Death Months: Rats UC-M UC-F T-I-M T-I-F 5 5 4 1 Mice UC-F Hamsters UC-M T-I-M o *> 3 CUSAROSS 01196 9ruzuit/'ual 3 I O - T E S 7 J^aJMyiatcy'u&i, Uric. s Monrh Number 1 2 " J "N 6 7 8 0 10 li 12* 13 14 15 16 17 13 19 20 ^T wX 22 23 TABLE IV TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Rats Cumulative Number of 1. lortalities at End of Month UC MF T-I Mp T-II MF T--III MF 0000 00 00 0020 10 2 -> A n 00 n- 024 D0 14 2351 6l 3 J-1 4 6 1 6 i 54 44S? 62 65 4 5 9 3 10 5 10 8 4 6 10 4 11 5 16 15 5 7 11 7 12 9 24 28 7 8 13 9 14 19 34 52 13 14 19 16 21 37 58 66 16 17 23 24 26 50 73 83 19 21 26 30 33 63 85 86 21 23 28 57 40 75 94 89 23 25 31 45 46 87 100(4) 100 28 27 35 53 55 90 100 100 33 28 38 59 64 94 100 100 38 31 43 66 71 94 100 100 46 34 47 73 77 94 100 100 52 42 52 SO 100(18) 100(4) 100 100 57 48 63 39 100 100 100 100 64 54 72 92 100 100 100 100 T-IV p 0 0 0 0 0 0 1 4 1 17 40 46 76 S6 100(7) 100 100 100 100 ICO ' 0 ft 100 * Includes 5 males and 5 females f: each group excludi,n2 T-IV s acr: ,ced :c.' cytogenic study. () Indicates moribund or sick animals sacrificed. CUSAROSS 01197 !}SIO- i 2 S T !)nc. 9 Month Number 1 2 7 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE V TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Albino Mice UC M Cumulative Number of Mortalities at End of Month T-I T- II F MF MF T-III M F 0 0 C 5 8 12 18 18 23 28 30 34 44 54 67 82 82 82 92 100 100 100 100 00 00 000 00 3 0 000 7 4n' iv 5 4 i 4 7 2 26 6 4 2 8 7 2 30 6 8 3 10 Q 5 31 11 9 12 13 23 5 32 14 16 30 30 46 8 38 24 37 58 56 7 * 10 42 31 78 82 76 98 15 54 46 96 94 100 100 16 57 66 98 95 100 100 23 70 80 99 97 100 100 28 79 91 100 100 100 100 39 88 97 100 100 100 100 46 100 100 100 100 100 100 54 100 100 100 100 100 100 58 100 100 100 100 100 100 70 100 100 100 100 100 100 77 100 100 100 100 100 100 81 100 100 100 100 ICC 100 89 100 100 100 100 100 ICO 92 100 100 100 100 100 100 CUSAROSS 0119, 9tul(4it%uU. B I o - T 5 5 T Jtalwxzt&'Uei., 9nc. 10 Month Number 1 2 0 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 TABLE VI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Summary of Mortality Data - Golden Hamsters UC M Cumulative Number of Mortalities at End of Month T-I T-II F M F MF T-III M F 544 8 11 lu -> - - o 13 16 9 18 16 13 18 16 13 28 24 14 28 24 14 29 24 14 30 26 15 31 28 18 36 34 23 40 43 28 46 49 39 61 53 50 78 58 57 SI 61 62 85 62 65 90 68 71 96 73 71 100(2) 80 73 100 82 78 100 85 4 12 , 16 16 16 19 19 20 20 21 33 49 58 72 83 85 86 89 95 100(3) 100 100 7 9 15 16 20 22 23 25 26 26 37 46 54 66 74 76 77 79 86 100(13) 100 100 5 16 -* wi~\ ia 20 21 33 35 36 37 38 46 49 53 55 59 66 75 84 39 100(7) 100 100 2 10 ,4 am i- 15 16 18 19 20 23 28 40 49 61 71 84 86 88 92 100(5) 100 100 100 - u I: If 1_ Of. 2 2c 2C 36 4: 58 69 84 10C 100 100 100 100 IOC IOC i oc () Indicaies mcribu:nc or sick animals sacr ificed. CUSAROSS 01199 !)3 10- i 5 S T $rt. 11 V. Hematologic Data Twenty-three month hematologic data are presented in Tables VII through X. CUSAROSS 01200 TABLE Vli TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rats C ii oup Animal Number Total Leukocyte Count (thou sands/mm Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value (90) Test Month: 23 l liilmaU-d ( .'ull l l'oI o oCn > o C/3 C/3 o oto 1 4 5 7 15 17 Jti 19 22 27 28 38 37 80 81 ' 82 47 89 52 53 Mean 9.0 11.3 8.7 9.8 13.0 16.0 11.5 14.8 8.0 10.8 15.6 9.7 11.6 15.0 6.6 8.8 7.9 9.2 11 .6 10.4 11.0 8.03 8.89 8.97 7.30 5.30 6.91 8.52 6.40 7.79 6.57 6.14 8.17 7.88 8.19 7.84 8.55 8.48 6.65 7.88 8.70 7.65 14.2 16.0 15.6 16.1 11.5 14.6 15.7 14.8 15.2 15.4 18.8 15.2 15.6 16.2 16.0 15.9 17.0 14.0 16.0 16.2 15.3 48 53 51 50 80 48 54 46 50 50 45 48 52 52 51 50 55 44 50 52 49 w nt in -I b* f & r r\j  tiro up T-l o CCrt > c Cir/D, o u ro TABLE VII continued TEST MATERIAL: Vinyl Chloride (Ethyle u- Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Alb no Mice and Golden I lamsters Hematologic Data - Male Rats Animal Number Total Leukocyte Count (thousands/mm Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit V alue (%) Test Month: 23 201 207 200 212 214 222 223 225 220 227 228 232 233 234 238 ' 241 24 0 250 235 .! Lh) i.li ,m 9.8 14.0 12.4 12.4 8.7 9.2 10.8 ' 14.8 1 1.8 5.4 7.0 9.2 10.4 7.3 10.5 12.2 13.7 18.0 (>. 4 8.7 10.7 6.54 6.54 3.82 7.26 6.91 6.38 6.44 6.44 7.83 6.57 7 .83 7.80 8.19 8.45 7.75 9.37 6.77 7.47 6.95 7.18 7.12 12.4 14.0 8.6 14.4 14.3 13.7 13.8 10.4 15.2 13.7 15.2 14.3 15.8 15.6 15.4 16.4 13.6 14.0 13.8 14.6 14.0 40 44 30 46 44 42 46 38 49 42 47 44 50 49 48 52 41 45 42 44 44 it I U) O A -i m in H 1 $ u>*--* TABLE VUI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats G rui ip Animal Number Total Leukocyte Count (lhousands/mm 3) Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Concentration (g/100 ml) Test Month: 23 Hematocrit Value a) Test Month: 23 l1nlreuted Control n Ca/3 > o C/3 C/1 o 102 105 107 1011 11J 112 113 1 17 1 !H l 10 121 123 12-1 125 127 ' 1 30 1 31 132 1 33 1M Mean 13.0 9.1 7.8 15.3 8.3 15.0 10.3 3.6 6.1 11.1 9.0 14.4 10.8 6.1 5.8 20.0 5.0 5.9 8.1 7.0 9.0 5.02 6.78 6.38 7.15 5.29 4.49 5.49 7.26 5.80 5.43 6.10 4.90 6.25 7.27 7.10 2.69 7.18 7.60 6.54 7.30 6.10 12.0 14.9 13.2 14.6 10.4 9.1 12.2 14.6 12.0 12.2 13.6 10.0 13.2 14.8 14.0 5.7 14.6 14.4 13.5 14.4 12.7 40 48 42 46 34 30 38 46 38 38 42 35 40 46 43 22 46 45 42 45 40 5s. 6. to o -I Ml in --I r .u Croup TS TABLE VIII continued TEST MATERIAL*. Vinyl Chloride (Ethylen ; Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Rats Animal Number Total Leukocyte Count (thou sands/mm Test Month: 23 Erythrocyte Count (millions/mm^) Test Month: 23 Hemoglobin Ooncen tralion (g/100 ml) Test Month: 23 Hematocrit Value (%) Test Month: 23 1)5 322 326 337 352 354 363 Mean 9.6 8.4 24.6 9.0 26.4 14.9 5.9 14.4 7.11 6.95 2.01 8.24 6.28 4.42 8.60 6.23 13.2 13.6' 4.4 13.8 10.8 8.8 13.5 11.2 43 43 17 49 36 30 46 38 V*s ! O n c > pa O 00 oo o to Group Animal Number Untreated ( Sm trul 17 28 `10 T-l 2b 0 TABLE IX TEST MATERIAL: Vinyl Chloride (Elhyhne Derived) V^- S. tw Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Male Rat ; -1 JJJ Ring* 5 10 11 Differential Leukocyte Count (number of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Niunbet * Month Number : Month Number: Month Number: 23 23 23 23 2 41 52 0 0 52 37 0 CO 0 40 1 0 1 0 -t Basophils Month Number: 23 0 0 0 I rh 10 0 11 79 0 0 0 1 Several of the rmg-lurm neutrophils were twisted like a figure 8. O C co > po O CO CO o Ctoo/i O' frju ita la l 3 I O - T EST A G run p Animal Number Untreated t bn tro 1 108 112 117 130 r i 320 382 354 TABLE X 'LEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study - Albino Rats, Albino Mice and Golden Hamsters Hematologic Data - Female Ran. Ring* Differential Leukocyte Count (lniinbi r of cells per hundred) Neutrophils Band Segmented Lymphocytes Monocytes Eosinophils Month Number Month Number: Month Number: Month Number: 23 23 23 23 Basophils Month Number: 23 71 34 52 5 1 0 M0 52 31 1 2 0 70 30 63 0 0 0 11 1 34 54 0 0 0 11 0 35 53 1 0 0 13 0 31 54 1 1 0 90 32 57 2 0 0 t- Several of the ring-form neutrophils were twisted like a figure 8. !)ri&uitiUit B 1 O * T c S T J!.-dtfyiatiyued., Htvi, 18 VI. Gross Pathology Tables XI, XII and XIII present suspected treatment-related tumors based on lessions found during gross necropsy. These lessions will be evaluated by histopathological examination to determine their true value. Tumor Key C ESC P PMA S = cannibalized -- escaped = postmortem animal = valid evaluation precluded by postmortem autolysis = sacrificed animal = animal s:;a alive CUSAROSS 01207 SruiiidiAiGj, 3 I O - T S S T -izJuyiaMytiei., IJrtC. 19 TABLE XI TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats GrouD Animal Number Days on Test Untreated Control 1 2 7 5 & 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 3^ 35 36 557 " -'1 A J _/ VJ 372 411 504 556 564 532 590 331 656 681 712 609 607 424 645 712 611 402 138 365 146 612 Mortality Data Liver Soleen Lung A P t. A A P A P PMA P PMA PMA PMA P A P A A A P P A P P P SE A A 4D. PMA P P PMA A PMA PMA Skin Misc. X X X X Kicnev cVSAROSS 0120H On^H&i'Ual B I O - T E S i JiaMosiatosuei' Sue. 20 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity S:udy Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 37 Control 38 continued 39 40 ' 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 Df O 64 65 66 67 68 69 70 71 72 A 660 P 360 S X - rA\ A 667 SE 702 PMA 524 PM A 619 P 703 A D J. A 673 P 204 P A A 360 S 360 s 692 p X A 641 P 347 PMA 463 PMA 272 P A 456 D A 572 P 581 P 511 P A 360 S \r 626 P 578 PMA a X X Kidney X X X CUSAROSS 01209 B1O-7EST ^Ktuxitial TA3LE XI continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic \"apor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 73 Control 74 continued 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 GO 100 A 599 P 541 O 5V D 675 l ?. A A X A A 685 P 603 P 360 S XX 699 P 595 P 587 P 713 PMA 384 D 302 P 706 PMA 507 P 415 P 409 ? 384 P 591 P 168 p 474 Ao 496 P 710 p X X X X X CUSAROSS 01210 JftieLuinlaL 3 1 O - T H S T JlaltoAcdoAiei', 3^ 22 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Days Animal on Group Number Mortality TestData Liver Spleen Lung Skin Misc. 201 A 202 462 P -- V -J 2o- 146 668 r 'L La iD. 205 361 S X 206 642 p 207 A 208 701 PMA 209 A 210 536 P 211 189 P 212 A 213 703 p X 214 A 215 145 P 216 568 P X 217 599 P X 218 718 P 219 529 P 220 101 PMA 221 541 P 222 A 223 721 P 224 668 io. X 225 A 226 A 227 A 228 A 229 675 P 230 74 PMA 231 719 ? X 232 A 233 A 234 235 324 PMA 236 645 p V CUSAROSS 01211 Srjz+uiu&l 310- I S S T jiabasuitosuei, Dhc. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 237 136 PMA continued 238 A O ? G 646 240 261 Z 241 722 p 242 693 p 243 669 PMA 244 611 P XX 245 595 P 246 A 247 695 P X 248 703 P 249 526 P 250 A 251 A 252 508 P X 253 113 P 254 693 P 255 A 256 361 S X 257 634 PMA 253 34 PMA 259 581 P 260 617 P X 261 624 P 262 275 PMA 263 274 P 264 361 S 265 693 P 266 318 P X 267 662 P X 26S A 269 642 P X 270 QQ C 271 534 P 2 72 640 P Thymus Kidney X X Kidney ^* CUSAROSS 01212 rh m x SncLiit'UcJ, 3 10" I E S T ^aluyuzto*'Ue6., Httc, 24 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 273 690 P continued 274 661 SE 7~~ ^" 1 - 27o iio P.MA 277 388 P 278 569 P 279 361 S 280 383 P X 281 5S5 p 282 A 283 204 P 284 670 P X 285 A 286 665 SE X 287 547 PMA 288 531 P 289 43 ESC 290 438 P 291 412 ESC 292 A 293 541 P 29-t 573 ? 295 224 P 296 89 PMA 297 94 PMA 298 249 PMA 29 361 S X oo 547 P X X X CUSAROSS 01213 Sruzultiial S O - T S S T JtalMyiattyu&i,, !)hc. 25 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Grouo Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 401 495 P X 402 505 P 625 D X X . -iO-i 405 561 474 v p X X Pancreas 406 534 P XX 407 527 SE X 408 555 P X 409 535 P 410 340 PMA 411 485 PMA X 412 631 S X 413 631 S 414 506 D X X 415 64 P 416 597 P X 417 506 P X X 418 631 s X 419 574 p X 420 415 p V JX 421 604 p X 422 449 PMA 423 108 PMA 424 341 P X 425 589 'D L 426 626 s X X 427 529 PMA 42S 626 S X 429 611 P X 430 626 s 431 297 P X 432 317 PMA 433 361 S V CUSAROSS 01214 434 617 P X X 435 626 S X 43o 626 s * jrtduiiuai BIO- 1 - S 1 Jlaliasiattytiei-, 9*uz. TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lune Skin T-II 473 502 P ucn .in ued 474 544 13 C 476 229 D X X X 477 374 P X 478 196 PM A 479 590 PMA 480 231 PMA 481 525 P X 482 569 P X 483 596 P X 484 626 S 485 468 P 486 513 P X 487 223 PMA 488 223 PMA 489 361 S X 490 359 PMA 491 626 S 492 432 D X 493 465 P IQ * 612 P X 495 536 PMP 496 430 p X 497 446 p X "3 429 P 099 129 ? X 500 480 P X X X X X Mis c. Frostate Semina: vesic Lvrr.oh nodes CUSAROSS 01215 Urtduiiitiil B I O - T S 1 JtaMtyiaty'jjii', Dric. 28 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rais , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Test Mortality Data Liver Soleen Lung Skin Misc. T-III 601 355 SE 602 247 PM A r__ r> -i "i --- ) p y' yf\e* 402 P X v 605 366 P X 606 242 P 607 344 p X 608 384 P X X 609 361 S 610 439 P X 611 390 P XX Mesentery 612 236 P 613 394 P ... X 614 400 P X 615 411 P X 616 496 P 617 250 t> X 618 498 S X 619 426 P X 620 470 P 621 371 4D. 622 244 P X X dr\ 623 292 4 X 624 362 SE X X 625 341 SE X XX 626 344 P 627 -Ji Dr J-\ p x V 628 448 P X 629 389 P X X 630 424 P X 631 452 PM A 632 341 5E X X 633 3 41 p 634 ^ ' ? X X o 3 5 177 p 636 39 2 p X CUSAROSS 01216 - HridudiiiaL 5 I O - 7 E S T Jialuyiat&U&i., 9nc. OQ TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-III 637 405 P continued 638 412 P A to 361 c X VV O-'J - 59 P -X 641 359 SE 642 208 PMA 643 293 p X 644 498 S X 645 340 P 646 373 p X 647 258 P 648 314 P 649 402 SE 650 318 PMA 651 372 SE X 652 386 P X 653 281 P 654 452 P 655 343 SE 656 428 P 657 148 p X 658 427 PMA 659 453 P X 660 92 P 661 299 P X 662 339 P X 663 361 S X 664 373 SE 665 274 P 666 382 p X 667 383 SE X 663 361 S X 669 377 ? X 670 366 P X 671 333 SE X 672 310 SE Kidney X X Brain 5 rain CUSAROSS 01217 Li* 2* 3. n `/ruLui'usl 3 10- I Z S T Jlalio^zLyiUi., DriA 30 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vanor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 673 321 P XX continued 674 335 PMA n / -\ ^4 676 342 o 677 297 SE X 678 304 P 679 428 P X 680 273 PMA 681 314 P X 682 296 SE X 683 338 D4. 684 359 P X X 685 374 P X 686 360 P X 687 498 s X 688 443 p X 689 308 p X 6q0 393 PMA 691 413 U i. X 692 408 D +. 693 157 PMA 694 361 s X 695 455 D i. X 696 311 P 697 364 O 698 383 p 699 332 p X X V 700 143 P Misc. CUSAROSS 01218 y.izLiiilial 3 1 O - T - S T Jlsluyiaityued., !)hc. 31 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study .Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 101 661 SE Control 102 ' <*\ A o 104 649 p 105 A 106 360 S X 107 A 108 A 109 513 PM A 110 704 P 111 A 112 A 113 A 114 573 P 115 673 P 116 386 SE 117 A 118 A 119 A 120 619 p 121 A 1 22 575 P 123 A 124 A 125 A 126 563 PMA 127 A 128 313 P 129 557 P 130 A 131 A 132 A 133 A 134 A 135 492 PMA 126 \ r\ X X X X X CUSAROSS 01219 X 9mLuiued B I O - T E S T 2aJwAGityu&i, 9m. 32 TABLE XI continued TE5T MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 137 A Control 138 504 P -4.. ., ^ ?0 I 'v 140 A 141 612 P 142 A_ 143 A 144 619 P 145 718 P 146 A 147 452 P 148 A 149 360 S X 150 A 151 113 D 152 715 P 153 A 154 71 P 155 704 P 156 656 P 157 596 'O A. 158 A 159 652 SE 160 360 S 161 357 D 162 691 PMA 163 616 P 164 499 p 165 5^4 P 166 A 167 129 PMA 168 607 PMA 169 296 P 170 698 ? 171 272 PMA 172 X X X X X V V X CUSAROSS 01220 3 I O - 7 H S i Jtzkyiaivtie4., Unc. 33 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Grouo Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Mis c. Untreated 173 169 P Control 174 A 1"" O "> O 17o 177 611 p 178 361 S 179 640 p 180 A 181 660 P 182 A 183 A 184 665 SE X X X Adrenal giant 185 616 P 186 669 O 187 A 188 614 P 189 631 P 190 199 PMA 191 A 192 241 PM A 193 461 PMA 194 596 SE 195 A 196 A 197 495 SE 193 699 'D 199 531 p 200 361 5 X X Adrenal glan X X X V X A. dr er.ai clar CUSAROSS 01221 DndudiUaL B I O - T S T Jiahyiat&iieA., Unc. 34 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 301 460 P 302 652 SE X Adrenal gla 303 361 S 304 604 oa :: X 305 569 P X 306 174 PM A 307 479 PMA 308 238 P X 309 651 P X XX 310 512 P X 311 555 P X 312 595 P 313 404 DA X X X 314 516 P X 315 A 316 283 P 317 630 ? 318 247 D X 319 41 PMA 320 388 P X 321 460 P X X 322 A 323 641 P X X 324 691 PMA 325 522 p X X 326 718 SE X 327 616 P X CO 451 P 329 614 VA 330 413 1AD X V* L X V X 331 661 5E X 332 617 AD X 33 3 621 DL. X X 334 577 P X X 3 3 a 656 SE A Ac CUSAROSS 01222 SruiM^dal E ! O - I 5 1 J.zlt&iatosuj&4., !)kc. 35 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Animal Group Number T-I 336 continued 337 ~\ . 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 3 56 3 57 358 t-X s-Xo/ 360 361 362 f - .SCO 364 365 366 367 3 63 3o 370 371 7------; Days on Test 524 o07 632 180 214 588 760 573 180 116 427 361 466 597 300 540 449 449 531 49 51 547 493 333 454 476 523 428 361 521 > c. 1 1 , n " T D 1 Mortality Data Liver Soleen Lune P A --s P PM A P P PM A P PMA PMA. P S P P A o j. A p PMA P P PMA PMA PMA P A PMA PMA o p D v s PMA P ,V X X X X V -\ V A Skin X X X X X X X X X v X Misc. xcr.e', CUSAROSS 0122 DKcLtitraal 3 I O - 7 E S T J.aiMyiat&us4.' Dhc. 36 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, .Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Auiimal Number Days on Test T-I 373 continued 84 Mortality Data Liver Soleen Lung PX Skin 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 542 642 381 198 494 419 361 656 513 519 337 356 654 400 283 584 127 556 387 576 593 346 361 7C3 532 591 . SE P PMA P PMA S SE P P P PMA P PMA P PMA PMA PMA PMA D "D PMA S D P P X X X X X X V X X X XX X X X X XX X Misc. Kidney T_ Adrenal g! CUSAROSS 012 B I O - I e S I JlawyiattyU&i., 9nc. 37 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic V apor Inh alation Toxicity Study ' Albino Rats , Albino Llice and Golden Hamsters Susp ected Gross Tumor Observations in Female Rats Animal Grouo Number Days on Test jMortality Data Liver Soleen Lune Skin T-II 501 473 PMA 502 341 D X TV) 3 -- i 1 " 5 C 4 483 p 505 384 P X 506 360 p X 507 438 P 508 433 PMA 509 327 PMA 510 395 PMA 511 626 SE 512 348 D X X 513 295 PMA 514 624 P 515 377 DA X X 516 377 P 517 515 P 518 208 DA 519 356 D A X 520 360 SE X 521 143 P 522 626 S 523 480 p 524 361 s X 525 466 PMA 526 392 P X 527 3o4 ? X 528 471 PMA 529 315 PMA 530 420 P X 5 31 4S8 P 532 414 DA X 533 389 P X 5 3 4 437 P X ^ j j 238 PMA ^ 36 50 D A X 5T7 303 O X t X X XX X X x X X X XX . Mis c. Xicney CUSAROSS 01225 9'nduiiriiaL B I O - T = S I J.aJuvuztoAi&i., 9m. 33 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number T-II 538 continued 539 5-0 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 56S 56 570 2(l 572 573 Days on Test 377 316 3r4 341 281 306 356 487 428 373 396 303 361 336 335 427 500 461 399 626 496 393 321 314 222 314 452 402 o 26 366 429 361 443 417 363 416 Mortality Data Liver Spleen Lung PMA PMA A- 22 P p P P P P P P S PMA P p P PMA P S PMA P o ? p ? p s D p s p ? p p .tV X X X X X X X X X X X X X X X X X X X X X X X V X X X X X X X Skin X X X x 'V- X Misc. Pancreas Thymus Kidnev .-.cren; CUSAROSS 0122f ?rjdmiUaL B IO-TSS i ^ci<>-'yiauX'Uei, 39 TABLE XI continued TEST MATERIAL: Viny 1 Chloride (Ethyl er.e Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Susp ected Gross Tumor Observations in Female R.ats Group Animal Number Days on Test Mortality Data Liver Soleen Lung Skin T-II 574 276 P continued 575 325 p 5 - 6 J- . r7\ X ' 577 345 PMA 578 468 P 579 234 P 580 262 PMA 581 395 P X 532 411 P X 583 309 P X 584 505 P X 585 306 P X 586 429 P X 587 420 P X 588 419 P X 589 402 P X 590 311 PMA 591 311 D X 592 388 PMA 593 387 PMA 594 361 S 595 357 PMA 596 429 P X 597 417 PMA 598 454 p X 599 361 S X bOO 335 PMA X X X X X X X X X X x Misc. Lymph nodes CUSAROss 01227 9rt(L<.Uual 3 I O - 7 E S T Ja/uvuzk/ued., 9tvz 40 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Grouo Animal Number Days on Test T-III 701 702 703 : -J 705 706 707 708 709 710 711 712 713 714 715 716 717 718 719 720 721 722 723 724 725 726 727 72S 729 730 731 732 733 734 73 5 736 366 262 185 5 73 443 373 346 375 306 240 333 303 261 405 312 353 361 383 405 224 211 317 374 296 438 321 303 361 381 443 319 361 334 82 361 316 Mortality Data Liver P P c r- | P p P PMA SE P P PMA. D P P P S P P P p SE P ? ? P P S P TD PMA S SE PMA S PMA X X X X X X X X X X X X X X X X _VV X V X Lung Skin Mis c. X A Thymus X Salivary land X CUSAROSS 01228 Hftaxdi'uaL 3 1 O - I 5 S i JlzluyiGMyU&i., joe. 41 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin Misc. T-III 737 continued 738 7'0 740 741 742 743 744 745 746 747 748 749 750 751 752 753 754 755 756 iri 758 759 760 761 762 763 764 765 766 -- / --i I0l 768 7 69 770 77* 772 378 295 IR. 362 311 361 325 367 351 368 235 347 379 336 82 82 377 371 277 348 374 383 82 320 354 256 365 290 322 311 326 311 113 263 2S6 3 30 PM A D - n S PM A P PMA SE P P P P PMA PMA P P P P n PMA PMA p SE p -nL Dt. SE SE p ?} p p T3 .v x X X X X X X X X X X X x 'S -V X X X V v X X X X X CUSAROSS 01229 jfitLtiliial S 1 C - T c S 7 J!.zJyoAaloAie4., jric* 42 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gro ss Tumor Observations in Female Rats Animal Group Number Days on Test Mortalit y Data Liver Spleen Lung Skin T-III 773 314 P continued 774 343 p X X 3 39 P 77o 284 777 365 D X X 77S 299 C 779 325 PMA 780 353 SE X 781 389 P 782 322 p X 783 303 SE X . 784 372 PMA 785 283 D X 786 113 PMA 787 113 PMA 788 113 PMA 789 324 ? X 790 113 PMA 791 401 D X 792 339 p X 793 274 ? X 794 271 P V_ ^ 79 5 113 PMA 76 78 ESC 7G 7 78 ESC 798 348 ? X 799 78 ESC 800 78 ESC XX X Misc. Salivary gland Cervical lymph nodes Kidney CUSAROSS 01230 Dadi'.UZ'Mil BIO- i S S t J.oJionaianie6., Hkz. tj TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Rats Group Animal dumber Days on Test Mortality Data Liver Spleen Lung Skin T-IV 2401 2402 2-3 5 2404 2405 2406 2407 2408 2409 2410 2411 2412 2413 2414 2415 2416 2417 2418 2419 2420 2421 2422 2423 2424 2-25 2426 2427 242S 2429 2430 2^31 2432 2433 2434 379 359 LA 345 411 405 310 398 434 268 473 349 434 496 261 498 346 351 352 398 498 342 379 434 498 489 457 366 382 297 372 429 311 264 P PM A P p P PMA P P P P P SE P PMA S P P ? O s PMA PMA D s P p IKD D P PMA P P P X -VV X X X X X X X X X X y 4\ X X X V X X X X ,VV X X X X X Mesentarv X X X V x *T A V CUSAROSS 01231 j 3IO- 1 2 S T Unc~ 1 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters SusDected Gross Tumor Observations in Female Rats GrouD Animal Number Days on Test Mortality Data Liver Soleen Lung Skin T- IV 2437 continued 2438 385 306 P SE X 2439 2440 2441 2442 2443 2444 2445 2446 2447 2448 2449 2450 2451 2452 2453 2454 2455 2456 2457 2453 2459 2e60 2461 2462 2463 2464 2465 2466 2467 2468 2469 2 470 2471 C -* 7 2 Jo5 394 306 381 473 352 385 385 340 325 370 426 426 365 331 423 220 330 392 375 387 365 498 j2d 375 31S 411 356 365 432 424 361 383 414 r" PM A P P P P PM A P P P P PM A P PM A PMA D PMA PMA p P P PMA S SE P PMA 13 4 P PMA P 73 4 P PMA p X X X X X X X X X X X 4 X X X V V v X X r X X X X v X X X Misc. Cervical lymph nones Lymph nodes CUSAROSS 0123 SruLmital 3 I O - 7 H S l J.aMoAatosUel, Sac. 45 TABLE XI continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and C-oiaen Hamsters Suspected Gross Tumor Observations in Female Rats GrouD Animal Number T-IV 2473 continued 2474 --r 2-=7 6 2477 2478 2479 2480 2481 2482 2483 2484 2485 2486 2487 2488 2489 2490 2491 2492 2493 2494 2495 2496 2497 2498 2499 2500 Days on Test 447 431 3" 448 469 368 407 417 323 398 316 314 250 348 47 6 440 344 403 390 379 415 498 355 368 35o 2S5 _l 2 2 432 Mortality Data Liver Soleen Lung PX PX '- X ? 13 PMA PMA P PMA P P PMA SE P P P PMA P PMA PMA ?i ;a 5 p PMA PMA SE p D A X X X X X V A *XV'' X Skin X X X X X x Misc. .Meser.terv Ovary Kidney CUSAROSS 01233 Srtdu-ii'Ual 3 i C * I c S I JtsMosiGiosii&a, joe, 46 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Days Animal on Group Humber Mortality TestData Liver Spleen Lung Skin Misc . Untreated Control 801 802 t-i 8 01 805 S06 807 808 809 810 811 812 813 814 815 816 817 818 819 820 621 323 824 825 826 327 828 829 330 331 -i 833 534 835 560 dZ9 ^c; 1 i1 428 371 301 429 502 329 452 204 428 197 190 388 505 148 305 474 568 187 94 568 134 418 122 134 321 340 200 570 462 401 94 PMA PMA --> \ r \ PMA PMA PMA P p P P p PMA PMA PMA P 15 PMA PMA *D PMA P ? P o P.MA PMA PMA PMA ? PMA PMA PMA XD ? P CUSAROSS 01234 !)riU4it'ud. 3 10- I Z S i 9*"-- 4< TABLE XII continued TEST MATERLAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated Control ---------- 836 837 OO' S_ Sw 839 840 841 842 843 844 845 846 847 848 849 850 851 852 853 854 855 856 357 858 859 860 361 362 863 S64 365 Soo 8 c7 368 369 370 116 173 4 le 388 279 302 213 390 451 390 575 461 271 527 497 441 161 255 255 261 174 564 148 178 173 435 496 272 376 409 564 454 551 349 PMA P --' ' PMA PMA PMA PMA n PMA P P PMA SE PMA P ? PMA PMA PMA 4Z-> PMA PMA D PMA PMA D PMA P p PMA p SP D Kidney CUSAROSS 01235 D I O - I Z S i JlzJMy^atosu&!., 9nc. *n 10 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Untreated 871 Control 872 3 74 875 376 877 878 879 8S0 881 832 883 884 885 886 887 888 889 890 391 892 393 894 895 896 897 898 399 900 Days on Mortality TestData Liver Spleen Lung 176 o 567 PMA - ", D> ' \ 276 Zj 152 PMA 466 P 450 d 371 PMA 500 p 411 P 431 P 423 PMA 406 P 380 P 381 p 459 P 292 P 376 P 431 p 275 PMA 316 p 530 94 ?M \ 409 ? 378 n 262 PMA 423 P 354 ? 277 PMA 424 PMA Skin Misc. CUSAROSS 01236 9itdLu*/Ual B I O - T E S T JtalvyicUiyue&, Hhc. 49 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. 1001 1002 iUn,Lr /^j 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 1022 1023 1024 1025 1026 1027 1028 1029 1030 1031 1032 1033 1034 103 5 149 445 392 362 492 421 130 309 498 332 79 79 85 85 85 309 378 136 92 290 121 437 121 498 498 367 413 137 332 498 115 346 115 173 281 P P PMA P P P C PMA S PMA C PMA C C C p p c c p c p c s s PMA P P PMA s P P P PMA P Prostate X X Mesentery X X X Mesenteric r.c X CUSAROSS 01237 yndiUt-Ucd B I 0 - T E S T JiaksAat&u&i., 9tic. 50 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Mis c. T-I 1036 continued 1037 1038 1039 1040 1041 1042 1043 1044 1045 1046 1047 1048 1049 1050 1051 1052 1053 1054 1055 1056 1057 1058 1059 1060 1061 1062 1063 1064 1065 1066 1067 1068 1069 1070 407 150 373 196 265 205 275 377 378 123 145 247 149 498 243 389 121 196 118 196 149 145 85 121 346 165 271 121 104 498 121 332 286 434 121 P PMA P XD p PMA PMA P P PMA PMA P P S PMA P P P PMA P P PMA C c p PMA PMA C PMA S P P P P c X X Mesenteric r.c X X X X X X CUSAROSS 01238 9r:juiliial B 1 O - T E 5 T JiaJuyiatosued', 9sic, 51 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test T-I 1071 continued 1072 1073 1074 1075 1076 1077 1078 1079 1080 1081 1082 1083 1084 1085 1086 1087 1088 1089 1090 1091 1092 1093 1094 1095 1096 1097 1098 1099 1100 446 316 294 377 386 386 401 311 319 437 406 362 448 498 432 406 407 407 275 410 267 332 380 293 369 432 386 353 446 365 Mortality Data Liver Spleen Lung P PMA PM A. PMA P P P P P P P P PMA S P PMA P P P PMA P P P PMA P P P P P P X X X X X X X X X X X X X X X Skin Misc. Mesenteric nod dbdr.ev >kdn <:-v cusaross o,:39 yKC*iiiiial 3 I O - T 2 S I TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Mi sc. T-II 1201 120 2 20 2 1204 1205 1206 1207 1208 1209 1210 1211 1212 1213 1214 1215 1216 1217 1218 1219 1220 1221 1222 1223 1224 1225 1226 1227 1228 1229 1230 1231 1232 1233 1234 1235 320 277 324 225 274 296 254 291 275 309 286 331 351 331 322 359 293 318 272 291 226 285 291 225 269 374 299 25 284 310 276 311 290 297 308 P ID .T p P P P P P P P SE P SE PMA D P SE P PM A p P p D p p PM A PMA D Q p SE D p Di. X V A V1 X X X X X X X X X X X X X X X X x X A X V V X X X X X X Kidney X Mesenierv X X X X X X X X X Mesenteric X X X X Kidney X Lymph noc y x X CUSAROSS 01240 ^HcUdiiiaL B I O " T E S T _A?/uvtfrf/yujiA' 9kc* TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 1236 continued 1237 1238 1239 1240 1241 1242 1243 1244 1245 1246 1247 1248 1249 1250 1251 1252 1253 1254 1255 1256 1257 1258 1259 1260 1261 1262 1263 1264 1265 1266 1267 1268 1269 1270 348 340 317 268 292 143 368 303 302 310 389 268 288 300 340 290 258 258 271 282 264 401 292 303 304 287 313 383 244 299 276 249 180 302 303 P P P P P P P P P P P P PMA PMA P P P PMA P P P P P P PMA P P P P PMA P PMA P P P . X X x X X X X X X X X X X X X X X X X X X X X X X X X Kidney X X X X X X X Mesenteric n X X X X X X X CUSAROSS 01241 X $*tdu6btial B I O - T E S T JlabyiatiyUed., 54 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 1271 continued 1272 1273 1274 1275 1276 1277 1278 1279 1280 1281 1282 1283 1284 1285 1286 1287 1288 1289 1290 1291 1292 1293 1294 1295 1296 1297 1298 1299 1300 283 258 339 324 317 218 261 273 288 288 265 289 289 286 145 277 248 284 197 305 91 91 255 306 253 214 298 234 294 294 P PMA D P p P P PMA P PMA PMA P Tt.D P PMA P P P P P ESC ESC O P P SE PMA P PMA P X X X X X X X X X X X X X X X X X X X X X x X X X X X XX X X X X X X X X Misc. Lymph nod Kidney Salivary gi CUSAROSS 01242 B I O - T E S T J.aJuyLcMyue4., !)*iC, 55 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Susp ected Gross Tumor Observations in Male Mi Animal Group Number Days on Test Mortality Data Liver Spleen Lung T-III 1401 1402 140 3 1404 1405 1406 1407 1408 1409 1410 1411 1412 1413 1414 1415 1416 1417 1418 1419 1420 1421 1422 1423 1424 1425 1426 1427 1428 1429 1430 1431 1432 1433 1434 1435 143 248 276 264 169 93 219 130 208 306 304 312 277 312 221 273 248 280 255 239 237 274 288 220 245 234 274 236 282 127 290 211 291 235 254 PMA P ? P P C SE PMA P P P S PMA S PMA P SE P P P P P P P P P P P P PMA P P P P SE X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Misc. Mesentery CUSAROSS 01243 ^KcludJ/UaL B I O - T E S T laJt&ialcyu&i., 9tiC. 56 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number T-IH 1436 continued 1437 143S 1439 1440 1441 1442 1443 1444 1445 1446 1447 1448 1449 1450 1451 1452 1453 1454 1455 1456 1457 1458 1459 1460 1461 1462 1463 1464 1465 1466 1467 1468 1469 1470 Days on Test 257 121 310 312 258 179 220 121 254 288 287 230 165 108 144 278 311 252 290 295 254 311 267 241 215 258 252 248 274 312 302 255 281 310 277 Mortality Data Liver Spleen Lung P PMA SE S P PMA PMA PMA P P P P PMA ' PMA PMA P P PMA PMA P PMA P SE P PMA PMA PMA PMA P S P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin Misc, Kidnev CUSAROSS 01244 UncLuliial B I O - T E S T J.OMAHtoAi&i., !)nc. 57 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Mice Animal Group Number Days on Test MortalityData Liver Sdeen Lung Skin T-III 1471 continued 1472 1473 1474 1475 1476 1477 1478 1479 1480 1481 1482 1483 1484 1485 1486 243 240 241 263 260 302 265 198 226 250 260 287 283 231 224 312 PMA P P P PMA PMA PMA PMA PMA P PMA PMA P PMA PMA S X X X X X X X X X X X 1487 1488 1489 1490 1491 1492 1493 1494 1495 1496 1497 1498 1499 1500 266 276 236 229 148 230 306 194 241 312 325 262 221 224 PMA P PMA P PMA PMA PMA P PMA S PMA P *D PMA X X X X X X X X X XX Misc. Mesentery Cervix CUSAROSS 01245 !)ncMdiiiaL BIO-TEST ^aJuyuzityUei, 9hc, 58 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Days Animal on Mortality Group Number TestData Liver Spleen Lung Skin Misc. Untreated Control 901 902 903 904 905 906 907 908 909 910 911 912 913 ' 914 915 916 917 918 919 920 921 922 923 924 925 926 927 928 929 930 931 932 933 934 935 428 308 345 266 266 390 522 511 511 641 564 616 435 313 564 405 664 325 508 392 571 364 202 579 702 647 511 665 547 669 367 392 511 PMA P P P P PMA P P PMA PMA A PMA P-- PMA PMA PMA PMA PMA PMA PMA P P PMA PMA PMA PMA PMA P P PMA p SE PMA A PMA X CUSAROSS 01246 P3 I O - T E S T J^zJuVtsiJn* loJt Due. 59 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 936 Control 937 continued 938 939 940 941 942 943 944 945 946 947 948 949 950 951 952 953 954 955 956 957 958 959 960 961 962 963 964 965 966 967 968 969 970 99 209 427 271 582 326 492 511 374 572 511 666 579 709 321 471 440 423 579 551 432 209 371 315 486 672 578 714 450 574 322 575 P PMA ? P PMA P P PMA P PMA PMA P PMA A. PMA PMA A P SE A P PMA PMA P PMA P P PMA PMA P PMA P P PMA P CUSAROSS 01247 PriAuiiAial B I O - T E S T Jlakyuzi&U&t, !)kc. 60 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Scdeen Lung Skin Misc. Untreated 971 Control 972 continued 973 974 975 976 977 978 979 980 981 982 983 984 985 986 987 988 989 990 991 992 993 994 995 996 997 998 999 1000 569 449 500 508 526 408 416 526 300 572 405 374 434 500 579 372 667 504 573 452 522 429 94 547 598 666 662 577 439 467 P P ?Y A p PMA PMA PMA PMA P PMA PMA P PMA PMA P PMA PMA P PMA P PMA P P P PMA P PMA PMA PMA P CUSAROSS 01248 B I O - T E S T J^clxyuzianied., 61 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1101 271 PMA 1102 1103 435 375 P p 1104 307 P 1105 338 SE X 1106 329 PMA 1107 380 P 1108 359 P 1109 316 P 1110 192 P 1111 354 P - 1112 498 S 1113 414 P X 1114 368 P 1115 377 P X 1116 402 P 1117 264 PMA 1118 262 SE 1119 196 P X 1120 374 P 1121 343 P 1122 423 D X 1123 323 D 1124 333 p X 1125 396 PMA 1126 1127 249 3"? PMA p X 1128 354 P 1129 462 P 1130 308 PMA 1131 416 PMA 1132 329 P X 1133 360 P X 1134 85 C 1135 382 P X XX X X X Mesentery XX Kidney X X X Kidney XX X X Mesenteric X X X X Kidney X X Ki dney X Uterus X X Kidntv X XX x~ CUSAROSS 01240 O-TEST 62 TAI3LE XII continued TEST MATERIAL : Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc, T-I 1136 325 P X X continued 1137 246 PMA 1138 187 P X 1139 1140 232 353 PMA P X X 1141 1142 340 444 SE P X X X Mesenteric no 1143 1144 1145 351 236 370 P P P X Mesenteric no X Mesentery 1146 309 P XX 1147 398 P X Mesentery 1148 450 PMA. X 1149 1150 356 429 P P X 1151 380 P X 1152 54 C 1153 1154 388 353 P P X X X X Mesentery Mesenteric nod 1155 388 PMA Kidney 1156 1157 260 388 SE P XX 1158 1159 382 294 P P Kidney X 1160 1161 309 416 P PMA Stomach 1162 416 PMA 1163 253 P X XX 1164 1165 320 347 P PMA X X 1166 373 P 1167 233 P XX 1168 380 P Mesenteric no 1169 449 PMA 1170 55 C CUSAROSS 01250 - !)B I O T E 5 T JlQJvyu2tosue, !)fi~ 63 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal GrouD Number Days on Test Mortality Data Liver Spleen Lung Skin Mis c. T-I 1171 continued 1172 1173 1174 1175 1176 1177 1178 1179 1180 1181 1182 1183 1184 1185 1186 1187 1188 1189 1190 1191 1192 1193 1194 1195 1196 1197 1198 1199 1200 ' 55 304 416 355 319 218 428 341 320 341 290 342 295 397 373 284 295 355 343 339 261 305 308 309 247 323 416 123 498 202 C SE PMA P P PMA P P P P P P p P P PMA P PMA PMA P PMA PMA P P P P PMA PMA S P X X X X X XX XX XX X Ovary X Uterus X X Kidney XX X X Kidney X Kidney, Cerv X XX L terus xX X Mesenteric n< Kidney XX CUSAROSS 01251 S I O - T 5 S T Jl<zliosu2iaA&i., DtiC. 64 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number T-II 1301 1302 1303 1304 1305 1306 1307 1308 1309 1310 1311 1312 1313 1314 1315 1316 1317 1318 1319 1320 1321 1322 1323 1324 1325 1326 1327 1328 1329 1330 1331 1332 1333 1334 1335 Days on Test 95 259 258 240 290 226 228 296 190 265 231 327 373 214 270 257 278 270 255 333 236 237 316 278 275 277 230 250 218 276 299 222 258 278 278 Mortality Data Liver Spleen Lung P P P P. P P P P P P P PM A PPMA PMA P P P P 4Dr P P P P P P PMA P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Skin X X X X X - Misc . Lymph nod Mesenteric n CUSAROSS 01251 $KcUtii/iial B I O - 7 E S T JlzJt&uztoAie4.' 65 TABLE XII continued TEST MATERIAL : Vinyl Chloride (Ethyl ene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 1336 continued 1337 1333 1339 1340 1341 1342 1343 1344 1345 1346 1347 1348 1349 1350 1351 1352 1353 1354 1355 1356 1357 1358 1359 1360 1361 1362 1363 1364 1365 1366 1367 1368 1369 1370 227 214 230 30 5 275 206 285 179 270 220 275 177 298 261 208 216 315 274 252 271 307 224 241 278 264 245 259 430 244 310 269 335 287 258 276 PMA PMA D PMA P P P PMA P P P P P P P P P P P P P P P P p PMA P P P P P P P P P. y X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X XX X X XX X XX X XX Mis c. CUSAROSS 01253 - 9rtd+iiJ/iiaL B I O - T E S T jialtonaianie^., !}*c. 66 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats , Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 1371 continued 1372 1373 1374 1375 1376 1377 1378 1379 1380 1381 1382 1383 1384 1385 1386 1387 1388 1389 1390 1391 1392 1393 1394 1395 1396 1397 1398 1399 1400 293 316 250 322 322 262 316 234 256 369 278 205 232 275 176 217 340 273 295 251 256 183 272 297 329 498 277 498 212 448 P P PMA PMA P P P P P P P P P PMA P P P P PMA P P P P PMA S P s p PMA X X X X X X X X X X X X X X X X X X X X X X X XX X Kidney X X X X Kidney X X X X XX CUSAROSS 01254 Stidud&'Ual 3 I O - T E S T JlsAonato'iieA', !)*. 67 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test T-HI 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 1522 1523 1524 1525 1526 1527 1528 1529 1530 1531 1532 1533 1534 1535 205 225 258 221 206 157 294 229 220 258 272 215 284 283 295 256 302 293 312 263 275 312 222 277 312 312 256 252 265 27 6 195 179 228 222 210 Mortality Data Liver Soleen Lung Skin P P D P P PMA P SE P P PMA P P P P SE PMA PMA S P P S P P s s SE P P P P P P SE D X X X X X X X X X -- X X X X X X X X X X X X X X X X X X X X X X X X XX X X X X X X X X X X X XX XX XX X X X X X X X -T4- X X X Misc. Mesentery CUSAROSS 01255 B I O - T E S T J.aJta^aionied., Unc. 68 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 1536 continued 1537 1538 1539 1540 1541 1542 1543 1544 1545 1546 1547 1548 1549 1550 1551 1552 1553 1554 1555 1556 1557 1558 1559 1560 1561 1562 1563 1564 276 263 178 227 232 247 253 208 208 312 208 276 263 276 260 282 295 269 267 224 254 278 273 261 275 294 180 235 298 P PMA D P P P P SE S S P P P *o PMA PMA P p PMA P SE P P P P P P P P X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X XX XX X XX X X X X X X XX 1565 1566 1567 1568 1569 1570 206 240 220 309 191 312 P PMA P P P S X X X X X XX X X X CUSAROSS 01256 Misc. Mesentery Ovary Kidney Ureter Mesentery Gvarv 9nGu&ttial B I O - T E S T JlalvyiabyUeA,, 9+tc. 69 TABLE XII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Mice Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-III 1571 continued 1572 1573 1574 1575 1576 1577 1578 1579 1580 1581 1582 1583 1584 1585 1586 1587 1588 1589 1590 1591 1592 1593 1594 1595 1596 1597 265 257 255 194 221 243 212 250 269 273 259 290 272 299 295 239 239 197 264 248 226 113 202 240 236 118 240 P P SE P P P SE SE P PMA PMA P P P" PMA PMA P P PMA P P PMA P P PMA PMA D X X X X X X X X X X X X X X X X X X X X X XX X X XX XX X X X X X 1598 1599 1600 190 268 264 P SE P X X XX XX X Misc. Salivary glands CUSAROSS 01257 IJfidudMuaL B I O - T E S T 9*tc. 70 TABLE XIII TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1601 Control 1602 1603 1604 1605 1606 1607 1608 1609 1610 1611 1612 1613 1614 1615 1616 1617 1618 1619 1620 1621 1622 1623 1624 1625 1626 1627 1628 1629 1630 1631 1632 1633 1634 1635 447 591 591 452 529 492 596 565 591 64 8 697 46 649 536 698 107 107 44 186 151 83 51 96 54 A PMA P P P PMA P SE P A P A A PMA A A C P C A A P P A P A PMA PMA PMA PMA PMA PMA C PMA C CUSAROSS 01258 9rA+utaial BLO-TEST ^alioAaliyu&i, 71 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. Untreated 1636 Control 1637 continued 1638 1639 1640 1641 1642 1643 1644 1645 1646 1647 1648 1649 1650 1651 1652 1653 1654 1655 1656 1657 1658 1659 1660 1661 1662 1663 1664 1665 1666 1667 1668 1669 1670 99 99 136 207 199 199 40 66 123 123 88 201 177 157 541 363 157 395 61 2 169 688 2 14 524 591 55 14 363 11 576 519 708 PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA A P PMA C P P C PMA A P P PMA C P C P PMA P CUSAROSS 01259 !)tuiudiiuU, BIO-TEST VAv~j. *i**r 72 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Days Animal cn Group Number Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1671 Control 1672 continued 1673 1674 1675 1676 1677 1678 1679 1680 1681 1682 1683 1684 1685 1686 1687 1688 1689 1690 1691 1692 1693 1694 1695 1696 1697 1698 1699 1700 695 243 701 686 479 593 436 575 325 511 651 246 108 108 529 430 530 467 319 503 121 303 P P A A P P PMA P P A P A A PMA P P PMA PMA PMA P P A P P PMA P P A PMA CUSAROSS 01260 B I O - T E S T Jlaltosiato'u&t', !)* 73 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1801 A 1802- A 1803 666 P 1804 61 C 1805 59 C 1806 85 P 1807 44 PMA 1808 382 P 1809 371 P 1810 589 P X 1811 100 PMA -- 1812 100 PMA 1813 533 P 1814 575 P X. 1815 622 P 1816 631 P X 1817 137 PMA 1818 191 PMA 1819 148 PMA 1820 100 PMA 1821 65 PMA 1822 164 PMA 1823 111 PMA 1824 175 PMA 1825 607 P 1826 523 PMA 1827 51 C 1828 375 PMA 1829 649 P X 1830 A 1831 607 P 1832 377 PMA 1833 108 PMA 1834 108 PMA 1835 108 PMA 1836 108 PMA Kidney Lymph nod Kidney Kidney Kidney X CUSAROSS 01261 CUSAROSS 01262 jruiudi\uzL B I O - T E S T Ji.'zlxyuzttyu&i; D*"-c. 74 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Group Animal Number Days on Mortality Test________ Data Liver Spleen Lung Skin Misc. T-I 1837 continued 1838 1839 1640 1841 1842 1843 1844 1845 1846 1847 1848 1849 1850 1851 1852 1853 1854 1855 1856 1857 1858 1859 1860 1861 1862 1863 1864 1865 1866 1867 1868 1869 1870 1871 1872 614 108 11 696 386 14 64 420 373 635 47 47 47 572 574 531 72 248 77 94 109 141 196 101 632 206 206 206 206 312 570 202 55 P PMA A C A PMA P C PMA PMA PMA P PMA PMA C P P P C PMA PMA PMA PMA PMA P PMA S PMA PMA PMA PMA P PMA A PMA PMA X X Kidney CUSAROSS 01264 A w B 1 O - T 5 S T Xalvyuzttyu&i, 75 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal GrouD Number Days on Test Mortality Data Liver Spleen Lung Skin T-I 1873 continued 1874 1875 1376 1877 1878 1879 1880 1881 1882 1883 1884 1885 1886 1887 1888 1889 1890 1891 1892 1893 1894 1895 1896 1897 1898 1899 1900 64 24 485 o 4. / 460 684 684 711 611 279 555 597 616 45 45 576 587 310 289 347 PMA C P c p p A P A p p A A P P P P A C C P P SE A PMA A PMA A X X X X X X X Misc . Kidney Kidney CUSAROSS 01265 !)riiziiitr'uaL BIO-TEST J!.3Jit\/uitosu&, 0*r. 76 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______________ Misc. T-II 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028 2029 2030 2031 2032 2033 2034 2035 2036 107 36 298 201 101 162 86 95 113 48 24 6 109 43 424 632 100 203 40 186 129 83 61 111 100 100 100 100 100 594 100 100 632 632 590 589 PMA PMA PMA p PMA PMA PMA PMA PMA PMA PMA. PMA PMA PMA PMA S PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA PMA P PMA PMA S S P P CUSAROSS 01266 Sucutit/Ual B f O - 1 EST J.altcyuzia'ueS, Unc. 77 TABLE XIII continuecl TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-II 2037 continued 2038 2039 2040 2041 2042 2043 2044 2045 2046 2047 2048 2049 2050 2051 2052 2053 2054 2055 2056 2057 2058 2059 2060 2061 2062 2063 2064 2065 2066 2067 2068 2069 2070 2071 2072 632 90 370 238 208 225 107 64 238 85 288 486 46 249 415 561 532 632 244 576 588 9 10 41 33 9 12 221 221 7 10 632 171 391 108 108 S C p P PMA P PMA PMA P C PMA P C P P P P S P P P C PMA PMA PMA C PMA PMA PMA C C s P P PMA PMA X X X X X ^ I ^ 5 1 ~' Kidney CUSAROSS 01267 !)nduiiUaL B I O - T E S T J?aIvyiatoni&t, 9*tc* 78 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin T-II 2073 continued 2074 2075 2076 2077 2078 2079 2080 2081 2082 2083 2084 2085 2086 2087 2088 2089 2090 2091 2092 2093 2094 2095 2096 2097 2098 2099 2100 632 469 till 632 7 632 101 101 127 632 93 632 107 100 44 158 44 590 582 632 632 9 388 32 528 535 632 99 S P n S c PMA PMA PMA P S C s PMA PMA PMA PMA PMA P P S S C P C P D s P X X X X X X X X X X XX X Misc. Kidney CUSAROSS 01268 9KthuArUiUiL 5 ! O "TEST 79 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, A.lbino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-III 2201 348 P X 2202 2203 54 405 C P X 2204 192 PMA 2205 219 P X 2206 434 ' P X 2207 231 PMA 2208 101 P 2209 206 PMA 2210 417 P X 2211 350 P -X 2212 108 PMA 2213 367 PMA 2214 422 P XXX 2215 582 P XX 2216 179 P 2217 552 P 2218 422 PMA 2219 219 PMA 2220 196 P 2221 386 PMA 2222 346 P X 2223 346 PMA 2224 346 PMA 2225 496 P X 2226 365 SE X 2227 100 P 2228 305 PMA 2229 330 P X 2230 441 P X X 2231 377 P X 2232 189 P 2233 422 P 2234 340 P 2235 16 C fancreaa CUSAROSS 01269 2*AiUtiial B I O - T E S T J.alt&iato'ue&, 9*ic. 80 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal GrouD Number Days on Test Mortality Data Liver Spleen Lung Skin Misc . T-III 2236 339 P continued 2237 591 S X 2238 529 P 2239 478 PMA 2240 270 PMA 2241 517 P X 2242 590 P 2243 591 PMA 2244 100 PMA 2245 477 P X 2246 484 P X x 2247 139 PMA 2248 404 P X 2249 147 PMA 2250 373 P X 2251 46 C 2252 137 P 2253 149 P 2254 278 P X 2255 295 P X 2256 361 PMA 2257 395 P X x 2258 547 PMA 2259 591 S XX 2260 591 S X 2261 508 SE XX 2262 46 C 2263 408 P X 2264 474 PMA 2265 270 PMA 2266 373 P X 2267 372 PMA 2268 39 C 2269 176 PMA 2270 351 P X Kidney CUSAROSS 01270 9mAu6ZsuoI BIO-TEST JiaMosicMyiiei, 9tiC. 81 TABLE XIII continued TEST MATERIAL : Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Male Hamsters Animal Grouo Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-III 2271 324 P X continued 2272 2273 54 338 C D 2274 411 P X A 2275 591 S XX 2276 569 PMA 2277 323 SE X 2278 155 PMA 2279 85 ESC A 2280 85 ESC ^ 2281 85 ESC 2282 64 ESC 2283 85 ESC 2284 64 ESC 2285 385 P 2286 286 P X 2287 26 C 2288 360 P X Kidney 2289 330 PMA 2290 448 P X 2291 438 PMA 2292 438 P X Mesentery 2293 326 PMA 2294 359 PMA 2295 591 S 2296 211 PMA 2297 285 PMA 2298 38 C 2299 155 PMA 2300 99 PMA CUSAROSS 01271 Jndiuiikd B I O - T E S T JlaliGAatoAi&i,, 82 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Days Animal on Group Number Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1701 Control 1702 1703 1704 1705 1706 1707 1708 1709 1710 1711 1712 1713 1714 1715 1716 1717 1718 1719 1720 1721 1722 1723 1724 1725 1726 1727 1728 1729 1730 1731 1732 1733 1734 1735 632 632 23 43 414 426 559 108 95 137 95 7 7 68 104 116 137 505 591 629 495 130 589 404 91 131 128 410 127 127 454 23 70 104 271 S S PM A P P P PMA PMA PMA PMA C PMA PMA PMA P PMA P P P P PMA P P PMA PMA PMA PMA PMA PMA P PMA C PMA PMA Kidney CUSAROSS 01272 B i O - T E S T JlobtyiGt&ue'i, Unc. 83 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Days Animal on Group Number Mortality TestData Liver Spleen Lung Skin Misc. Untreated 1736 Control 1737 cnrCrued 1 : 3 8 1739 1740 1741 1742 1743 1744 1745 1746 1747 1748 1749 1750 1751 1752 1753 1754 1755 1756 1757 1758 1759 1760 1761 1762 1763 1764 1765 1766 1767 1768 1769 1770 1771 1772 411 103 411 97 611 168 351 79 415 52 54 592 530 118 186 65 30 233 53 194 373 59 595 208 147 147 89 307 53 582 541 567 575 47 367 116 PMA PMA PMA PMA P PMA PMA C P C c p p PMA P PMA C PMA C PMA PMA PMA P PMA PMA PMA PMA PMA C PMA p P P C PMA PMA PMA CUSAROSS 01273 !}HCMdX/iuzl B I O - 7 E S T XalsaA&tafiieA., 9kc~ 84 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Untreated 1773 Control 1774 continued- 1775 1776 1777 1778 1779 1780 1781 1782 1783 1784 1785 1786 1787 1788 1789 1790 1791 1792 1793 1794 1795 1796 1797 1798 1799 1800 Days on Test 193 198 249 267 283 114 190 362 340 314 38 200 587 27 341 43 571 464 193 435 14 400 542 536 506 539 547 531 Mortality Data Liver Spleen Lung P P PMA PMA PMA PMA PMA PMA PMA C P P PMA PMA C P P PMA P C PMA P P P P P PMA X Skin Misc. CUSAROSS 01274 B I O - T E S T lalfOAaiyu&i, 9*tc. 85 TABLE XIH continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Mortality Test_____ Data Liver Spleen Lung Skin_______Misc. 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915 1916 1917 1918 1919 1920 1921 1922 1923 1924 1925 1926 1927 1928 1929 1930 1931 1932 1933 1934 1935 1936 104 187 188 141 394 153 200 57 84 200 113 201 108 120 131 164 580 49 49 131 106 311 119 119 119 133 61 52 127 572 578 Q/ J81 74 126 191 PMA PMA P\( A PMA PMA PMA PMA PMA PMA P PMA P PMA PMA PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PML PMA PMA P P PMA PMA. PMA PMA PMA X X Kidney X CUSAROSS 01275 Dndi^iiuaL B I O - T E S T 2aMonalcyUed., Httc. 86 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-I 1937 continued 1938 1939 1940 1941 1942 1943 1944 1945 1946 1947 1948 1949 1950 1951 1952 1953 1954 1955 1956 1957 1958 1959 1960 1961 1962 1963 1964 1965 1966 1967 1968 1969 1970 1971 1972 191 180 185 00 473 553 417 54 493 435 451 608 47 53 83 467 476 313 47 51 59 578 632 544 632 40 56 86 174 33 31 107 178 592 397 411 PMA PMA PMA PMA P P PMA c, P P P P C c PMA P PMA PMA C PMA C P s p s ESC PMA C PMA C C PMA PMA P PMA p X Ovaries CtAR0SS 01276 9?JL<4&ugI B I O - T E S T lalu^iaiyiied., 9kc. 87 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Mortality TestData Liver Spleen Lung Skin______ Misc. T-I 1973 continued 1974 1975 1976 1977 1978 1979 1980 1981 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 524 14 467 31 371 487 86 577 581 494 424 542 94 128 207 193 65 389 55 488 493 24 191 632 33 144 603 88 P C P C P P PMA P P P P P PMA PMA PMA PMA PMA PMA C P P C P s PMA PMA P ESC CUSAROSS 01277 ynduii-'ujzl 8 I O - T E S T 2.abyiatiyUe&, Dhc, 88 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc. T-II 2101 2102 2103 2105 2106 2107 2108 2109 2110 2111 2112 2113 2114 2115 2116 2117 2118 2119 2120 2121 2122 2123 2124 2125 2126 2127 2128 2129 2130 2131 2132 2133 2134 2135 2136 602 9 486 - \ " 476 553 451 392 514 578 570 336 52 476 632 529 52 632 87 60 39 509 632 39 446 221 562 576 286 513 129 495 173 208 447 413 P C P P PMA P P P P P P_ PMA C P s P C s c c ESC PMA s ESC P r> p p p p PMA P PMA P P PMA X X X X X X X X Kidney Kidney X Mesente X X X Cervix X CUSAROSS 01278 y&dxdt'tial B ] 0 - i E S T !)*" 89 , TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Animal Group Number Days on Test Mortality Data Liver Spleen Lung Skin Misc . T-II 2137 continued 2138 2139 2140 2141 2142 2143 2144 2145 2146 2147 2148 2149 2150 2151 2152 2153 2154 2155 2156 2157 2158 2159 2160 2161 2162 2163 2164 2165 2166 2167 2168 2169 2170 2171 07 29 47 359 29 39 522 68 36 36 522 104 603 46 628 426 307 632 614 207 542 632 564 614 473 96 96 96 534 541 200 485 196 468 632 409 383 C C PM A C C p c c c p PMA P c p p PMA S D D P S P P PMA PMA PMA PMA PMA P P P P P S D p X X X X X V X X XX X Thymus C varies X CUSAROSS 01279 Sriduittial BIC-TEST Jai&naiyUe'., 9ko~ 90 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Grouo Animal Number Days on Test T-II 2173 continues 2174 2175 2176 2177 2178 2179 2180 2181 2182 2183 2184 2185 2186 2187 2188 2189 2190 2191 2192 2193 2194 2195 2196 2197 2198 2199 2200 456 489 541 too 462 492 53 566 570 9 514 520 202 47 0 261 212 194 245 541 536 29 193 508 625 596 632 558 547 Mortality Data Liver Spleen Lun^ P P D P SE P C P P c P p PMA P PMA PMA P X X X X X PMA P P c X X PMA SE P P S P P X X X X X X X Skin X X X X Misc . Kidney Cervix Ovaries CUSAROSS 01280 B J O - T E S T 2alityiat&ue4-, 91 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Mortality Test______ Data Liver Spleen Lung 2301 2302 2303 2304 2305 2306 2307 2308 2309 2310 2311 2312 2313 2314 2315 2316 2317 2318 2319 2320 2321 2322 2323 2324 2325 2326 2327 2328 2329 2330 2331 2332 2333 2334 2335 9 74 149 591 320 309 314 304 201 118 206 201 390 64 247 300 318 315 249 207 360 381 403 361 350 498 390 354 448 354 383 498 496 411 S9 C PMA n'w s p PMA PMA C C PMA PMA P PMA PMA PMA PMA P PMA PMA PMA PMA PMA P P D s P p p p PMA S P PMA C X X X X X X X X Skin________ Misc. CUSAROSS 01281 Druzuit'Uizl 3K3-TEST JiaJtosuz&yUei., c. 92 TABLE XIII continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters GrouD Animal Number Days on Test Mortality Data Liver Skin Misc . T-III 2336 continued 2337 2338 2339 2340 2341 2342 2343 2344 2345 2346 2347 2348 2349 2350 2351 2352 2353 2354 2355 2356 2357 2358 2359 2360 2361 2362 2363 2364 2365 2366 2367 2368 2369 2370 442 405 399 S7 409 490 219 286 403 332 419 403 8 41 54 96 118 244 359 8 353 48 385 207 352 96 100 96 96 96 96 305 439 591 407 P PMA P C P P PMA P P PMA PMA PMA C PMA C PMA PMA PMA P C SE C P PMA P PMA PMA PMA PMA PMA PMA PMA PMA P PMA X X X X X X X X X Stomach X X CUSAROSS 01282 ^KcLiii'Ual 3 I O - T S S T J!.QM&uzt&Ue, $?ic. 93 TABLE XIII continued TEST MATERIAL; Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study Albino Rats, Albino Mice and Golden Hamsters Suspected Gross Tumor Observations in Female Hamsters Group Animal Number Days on Mortality TestData Liver Spleen Lung Skin_______ Misc T-III 2371 continued 2372 2373 2374 2375 2376 2377 2378 2379 2380 2381 2382 2383 2384 2385 2386 2387 2388 2389 2390 2391 2392 2393 2394 2395 2396 2397 2398 2 3 qo 2400 367 383 'j7 "> p / 379 61 68 53 264 207 49 38 279 279 306 378 387 364 207 194 325 38 364 29 243 361 29 41 84 397 208 PMA PMA "D' r \ PMA PMA PMA C PMA PMA PMA ESC PMA PMA PMA P P PMA PMA PMA P C P C P PMA C C PMA PMA PMA CUSAROSS 01283