Document 6yxjqwOjO0Oj0Oy6mj6j7O1

$FP 0 9 ,QT7 THE DOW CHEMICAL COMPANY BENNETT BUILDING 2030 DOW CENTER MIDLAND. MICHIGAN 48640 September 7, 1977 John Lawrence Society of Plastics Industry, 355 Lexington Avenue New York, N. Y. 10017 Inc. J. T*. Seawell Manufacturing Chemist Association 1825 Connecticut Avenue Washington, D. C. 20009 Gentlemen: Rose Kaminski, Statistician from NIOSH has kindly sent me an August update of their angiosarcoma registry. Ms. Kaminski asks some questions about new cases that I cannot answer. will you please distribute this tabulation, calling attention to the need for additional data to complete the new cases? I have had excellent cooperation exchanging information with this NIOSH group and I encourage our membership to help them keep this registry. Sincerely, Corporate Medical Dept. Enclosure mh cc: John Stafford, PhD. Health & Environmental Prot. Plastics Division Imperial Chemicals Ind., Ltd. P.O. Box No. 6 Bessemer Road Welwyn Garden City Hertfordshire England AL7 IHD Rose Kaminski Illness Effects Section Surviellance Branch Division of Surveillance, Hazard Evaluation, and Field Studies NIOSH R. A. Taft Laboratories 4676 Columbia Parkway Cincinnati, OH 45226 CMA 004961 DEPARTMENT OF HEALTH. EDUCATION. AND WELFARE PUBLIC HEALTH SERVICE center f:j cc s r = c^ September 1, 1977 N a T i N A _ I N i T i T j TE F03 C C C L P 4 T 1 O N A L SAFETY AND ^ A l T ROBERT A TAFT LABORATORIES 4 6 ? G COLUMBIA P 4 R K W 4 > C i N C ' N N A T I OHIO 452Zis T. R. Torkelson, Sc.D. Corporate Medical The Dow Chemical Company Bennett Building 2030 Dow Center Midland, Michigan 48640 Dear Dr. Torkelson: Thank you for the Information concerning angiosarcomas associated with vinyl chloride in your letter of August 22, 1977 to Dr. Spirtas. We would like to obtain more details on the cases new to this office and would, therefore, appreciate any additional information you have on these, or better yet, the name and address of the person we could contact for more information. Also, to your knowledge, have these additional cases been microscopically confirmed? In regard to your question concerning the U.S. cases, you are correct about the name of case 18^ and case 23 was employed at the Great American Chemical Company in Fitchburg, Massachusetts. In regard to German case 8, I have enclosed a copy of the documentation we have received concerning the German cases. Several weeks ago you mentioned correspondence among Drs. Philip Landrigan, Hans Popper, Louis Thomas and Marcus Key concerning the validity of U.S. cases 14 and 15. I was unable to find any such correspondence in our files. I telephoned Dr. Thomas and Dr. Falk in regard to this matter and it was agreed that case 14 should be removed from our lists. Dr. Thomas stated that case 15 couldn't be discounted as an angiosarcoma since it was microscopically confirmed but that a determination couldn't be made as to whether or not this angiosarcoma was VC Induced. As a result, Table II will not be presented in the Current Intelligence Report we intend to submit to JOM. CMA 004962 Page 2 - Dr. T. R. Torkelson Since I spoke with you last, two more U.S. cases have been reported to this office. I have enclosed a revised copy of Table I, which includes these cases, plus the additional cases you provided. Again, thank you for the information you have provided. Sincerely yours, Enclosure Rose Kaminski, Statistician Illness Effects Section Surveillance Branch Division of Surveillance, Hazard Evaluations, and Field Studies CMA 004963 TABLE 1 AUCrST, 1977 REPORTED CAKES OF ANGIOSARCOMA OF THE LIV>'R AMONG VINYL lCHLORIDE POLY MERIZATION WQRKI'RS 1ST VC DX AGE YEARS TOT. DATE CASE BIRTH OR PVC ANGI0- AT 1ST EXP. YRS. OF COUNTRY NO. DATE EXP. SARCOMA DX TO DX EXP. DEATH BELGIUM 01 00-00-00 00-00-00 00-00-00 00 00 00 06-29-76 CANADA 01* 12-15-13 00-00-44 00-00-55 41 10 11 09-02-55 CANADA 02* 03-06-14 00-00-43 00-00-57 43 14 14 12-21-57 CANADA CANADA 03* 03-26-19 00-00-4 1 00-00-62 47 21 OA* 04-05-19 00-00-45 00-00-67 48 22 20 03-22-62 22 01-21-68 CANADA CANADA CANADA CANADA CANADA CANADA CZECH. CZECH. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. FED.REP.GER. 05* 06* 07* 08 09 10 01* 02* 01* 02* 04 05* 07* 08* 09* 10 05-07-11 00-00-44 00-00-68 57 24 12-15-19 00-00-47 00-00-71 51 24 11-09-19 00-00-46 00-00-72 53 26 05-13-20 00-00-61 00-00-73 53 12 07-19-21 00-00-46 00-00-74 53 28 05-16-15 00-00-53 00-00-76 61 23 00-00-28 00-00-57 00-00-73 46 16 00-00-26 00-00-51 00-00-66 40 15 06-04-30 10-01-56 09-19-63 38 11 07-26-31 10-14-57 09-25-70 40 13 09-04-30 04-16-57 00-00-74 44 17 01-01-32 12-16-62 00-00-75 43 13 09-29-26 04-15-54 00-00-75 49 17 10-19-17 04-19-54 00-00-75 58 22 12-13-34 12-02-59 06-16-76 42 17 AWAITING DETAILS 05 07-05-63 23 04-10-71 25 12-24-72 05 06-12-73 26 09-04-74 14 04-00-77 16 00-00-74 15 00-00-66 11 01-25-69 12 12-14-71 11 11-25-74 12 01-09-75 12 11-13-75 21 12-25-75 15 ALIVE FRANCE FRANCE FRANCE 01* 04-15-24 01-00-46 02-18-67 43 21 02 06-03-11 07-06-59 01-03-75 63 15 03* 00-00-19 00-00-46 01-00-75 55 29 19 02-19-67 12 01-24-75 29 06-29-75 FRANCE 04* 01-27-27 10-19-49 01-04-76 49 26 26 01-04-76 FRANCE FRANCE 05* 01-29-38 00-00-65 04-00-76 38 11 06* 04-14-34 00-00-58 09-00-76 42 18 10 05-13-76 17 09-12-76 FRANCE FRANCE GREAT BRIT. 07 00-00-27 07-01-50 07-00-76 49 26 08 00-00-00 00-00-00 00-00-00 00 00 01* 00-00-01 00-00-46 12-00-72 71 26 23 07-02-76 00 01-30-77 20 12-00-72 GREAT BRIT. 03 06-02-37 02-00-66 00-00-74 37 09 04 12-24-74 ITALY ITALY JAPAN NORWAY 02* 11-13-29 00-00-57 12-13-72 43 15 03* 03-14-20 00-00-53 07-10-75 55 22 01 08-01-22 04-00-53 08-21-74 52 22 01* 12-23-15 03-00-50 12-20-71 56 22 06 12-00-72 21 07-10-75 22 10-24-75 21 01-04-72 SWEDEN 01* 06-23-27 08-14-51 02-00-70 43 19 18 10-20-70 SWEDEN 03 AWAITING DETAILS SWEDEN 04 AWAITING DETAILS U.S.A. 01* 10-17-23 12-09-48 03-03-73 49 22 16 03-03-73 U.S.A. 02* 08-19-33 11-15-55 05-00-70 37 14 13 09-28-71 U.S.A._________ 03* 05-25-15 11-28-45 12-19-73 58 28 28 12-19-73 U.S.A. 04* 01-15-24 07-06-52 08-19-67 43 15 15 01-07-68 U.S.A. 05* Oi-25-12 06-19-44 04-09-64 52 20 18 04-09-64 U.S.A. 06* 00-00-29 01-17-62 02-00-74 45 12 12 07-24-75 U.S.A. 07* 05-03-22 '08-27-44 00-00-68 45 24 18 03-23-68 U.S.A. 08* 05-06-20 10-07-46 08-00-61 41 15 15 08-29-61 U.S.A. 09* 11-08-31 09-09-54 03-01-74 43 17 17 03-00-75 U.S.A. 10* 08-16-13 06-12-51 05-00-68 55 17 17 05-10-68 U.S.A. 11* 05-27-09 10-14-46 03-00-70 61 23 23 03-16-70 U.S.A. 12* 11-17-18 09-13-49 05-02-69 50 20 15 05-02-69 U.S.A. 13* 12-01-21 08-19-44 05-00-74 52 30 30 07-04-74 U.S.A. 16* 11-04-27 05-08-50 00-00-69 41 17 4 03-27-69 U.S.A, 17* 05-06-31 06-23-55 10-11-74 43 19 19 ALIVE U.S.A. 18* 04-22-28 09-15-54 00-00-75 46 21 13 11-02-75 U.S.A. 19* 00-00-15 00-00-43 06-19-75 60 32 32 ALIVE U.S.A. U.S.A. U.S.A. ,, 20* 08-31-17 00-00-55 01-30-76 58 21 21* 00-00-10 12-00-46 00-00-77 67 30 22* 10-02-23 00-00-49 01-00-76 52 27 18 01-30-76 22 01-02-77 27 12-04-76 U.S.A. U.S.A. 23* 0Q-00-23 09-08-58 00-00-00 50 00 24* 00-00-17 00-00-39 05-27-77 60 38 14 04-06-73 26 05-27-77 U.S.A. YUGOSLAVIA 25* 08-07-10 09-00-47 03-10-77 67 30 01* 04-05-14 00-00-53 04-08-73 59 20 20 03-10-77 20 04-08-73 .YUGOSLAVIA 02* 11-15-31 00-00-50 07-12-73 42 23 18 07-12-73 Total reported cases " 63 * - Indicates microscopically confirmed angiosarcoma of the liver. "00" - Indicates unknown data. CMA 004964