Document 3Qb2xZdZeKaKknLEzwjdv7aMy

ip M w - 32g ? 471 A R s n - 3^ DuPont-11418 TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 4 of 5 Laboratory Project ID: DuPont-11418 Test Guidelines: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (AUG-1998) AUTHOR: Susan A. MacKenzie, V.M.D., Ph.D., D.A.B.T. Study Completed on: August 1,2003 Performing Laboratory: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Work Request Number: Service Code Number: Page 908 of 1602 Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS -909- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANTORY NOTES Accidently killed (includes animals presented dead or moribund that have injured themselves or were inadvertently injured when being handled. In-life and necropsy findings may be used to make this determination.) Lesion Grading Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc.; A severity score, if appropriate, is also assigned as follows: Minimal: the amount of change present barely exceeds-that which is considered to be within normal limits. Mild: in general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. Moderate: the lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. Severe: the degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction. Comment: grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, etc.) Neoplasm Designations *B: Benign neoplasm, primary site *M: Malignant neoplasm, primary site Abbreviations Recov = recovery Subch = subchronic -910- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-1141 Individual Animal Listing k ' Showing animal data for individual animals STUDY ||TO 5425/male (* APPROVED PROTOCOL *) Dose Group s j T 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665008 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL- GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -911 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing fE Showing animal data for individual animals STUDY ^25425/male (* APPROVED PROTOCOL *) Dose Group : I 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665015 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, mild. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : ATROPHY, RETINAL, UNILATERAL, mild. PROSTATE : AGGREGATES, LYMPHOID, minimal. 665015 Continued on the next page .... -912- Company Sanitized. Does not contain TSCA CBI ,4*******'\ 11-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-1 1 4-1 STUDY Dose Group Individual Animal Listing i| Showing animal data for individual animals 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) x 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 665015 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX,' SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665016 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665016 Continued on the next page -913- Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-1 X4i5 Individual Animal Listing M Showing animal data for individual animals STUDY 1| ^ p H | K 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Giroup: J: 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665016 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, VOMERONASAL ORGAN, minimal. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW - 914 - mpany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________uuront-x 1^10 Individual Animal Listing Showing animal data for individual animals STUDY M p | M 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Grfflip 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665042 Accidentally Killed Duration of dosing-days: 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM,' ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID" GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SURACUTE/CHRONIC, minimal. LUNGS : MACROPHAGES, ALVEOLAR, FOCAL, minimal. HEMORRHAGE, ALVEOLAR, minimal. PANCREAS : FOCUS OF CELLULAR ALTERATION, BASOPHILIC, minimal. THYMUS : HEMORRHAGE., mild. PARATHYROID GLANDS : . MISSING. EYE(S} WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. 665042 Continued on the next page .... -915- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-1 m e Individual Animal Listing P S h o w i n g animal data for individual animals STUDY ! | J H H H 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose G;roup : x 0 mg/kg Treatment: 0 rng/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665042 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ORGANS NOT EXAMINED: PARATHYROID GLANDS 665043 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665043 Continued on the next page .... Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11410 Individual Animal Listing Showing animal data for individual animals STUDY b - 4 5425/male {* APPROVED PROTOCOL *) Dose Grroup : i 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665043 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. ' THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. 665047 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665047 Continued on the next page .... -917- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing B Showing animal data for individual animals STUDY P B (25425/male (* APPROVED PROTOCOL *) Dose Group :' jl 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665047 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal, LUNGS : HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. ADRENAL GLANDS : ADRENAL MEDULLA MISSING. PROSTATE : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, ORAL MUCOSA, minimal. 665047 Continued on the next page .... ompany Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-1141 Individual Animal Listing Showing animal data for individual animals STUDY ( 5425/male (* APPROVED PROTOCOL *) Dose Group : I 0 mg/kg Treatment: 0 mg/kg I Sex: Males .Animal Ref Microscopic & Macroscopic Findings 665047 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665049 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665049 Continued on the next page -919-- --Com"Ppaannyy bSaanni.ttiizzeedd.. D oes not contain T S C A C B I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing am Showing animal data for individual animals STUDY U B I |l25425/male (* APPROVED PROTOCOL *) Dose Group : I 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665049 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. PROSTATE : AGGREGATES, LYMPHOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665064 Terminal Sacrifice .Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665064 Continued on the next page .... -920- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Duroni-1 m o STUDY Dose Individual Animal Listing Showing animal data for individual animals 25425/male (* APPROVED PROTOCOL *) : I 0 mg/kg Treatment: 0 mg/kg I Sex: Hales Animal Ref Microscopic & Macroscopic Findings 665064 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, PERIPORTAL, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665068 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665068 Continued on the next page .... -921 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations D uPont-114 i s Individual Animal Listing m m * Showing animal data for individual animals STUDY I M M i BK5425/male (* APPROVED PROTOCOL *> Dose Group :* 1 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665068 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. PANCREAS : INFLAMMATION, FOCAL, mild. MANDIBULAR LYMPH NODE : LEUKOCYTOSIS, PLASMA CELL, MEDULLARY, mild. THYMUS : HEMORRHAGE, mild. ESOPHAGUS : MISSING. PROSTATE : AGGREGATES, LYMPHOID, minimal. 665068 Continued on the next page .... mpany Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing <1 Showing animal data for individual animals STUDY :|JH25425/male {* APPROVED PROTOCOL *) Dose Group 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665068 Continued from previous page Histopathlogy : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ORGANS NOT EXAMINED: ESOPHAGUS 665070 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665070 Continued on the next page . - 923 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Gn Animal Ref 665070 Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) 0 mg/kg Treatment: 0 mg/kg I Sex: Males Microscopic & Macroscopic Findings Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, ' SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. SKELETAL MUSCLE : MISSING. SCIATIC NERVE : MISSING. PITUITARY GLAND : CYST, mild. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. PARATHYROID GLANDS : MISSING. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. PROSTATE : AGGREGATES, LYMPHOID, minimal. 665070 Continued on the next page .... - 924Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing | Showing animal data for individual animals STUDY S p H | 25425/male (* APPROVED PROTOCOL *) Dose GrOTip : i 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665070 Continued from previous page Histopathology : NOSE : INFLAMMATION, TURBINATES, mild, with squamous metaplasia. No Microscopic Abnormality Observed : HEART, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW ORGANS NOT EXAMINED: SKELETAL MUSCLE, SCIATIC NERVE, PARATHYROID GLANDS 665076 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665076 Continued on the next page .... -925 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________ DuPont-11418 STUDY Dose GroupP Individual Animal Listing Showing animal data for individual animals 5425/male {* APPROVED PROTOCOL *) 20 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665076 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. LUNGS : MACROPHAGES, ALVEOLAR, FOCAL, minimal. EYE(S ) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. OPTIC NERVE NOT PRESENT, UNILATERAL. PROSTATE : AGGREGATES, LYMPHOID, minimal. URINARY BLADDER : AGGREGATES, LYMPHOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 665076 Continued on the next page .... - 926Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing IE Showing animal data for individual animals STUDY H R 5425/male (* APPROVED PROTOCOL *> Dose GrWip T ul 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665076 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665081 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. 665081 Continued on the next page .... - 927Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY : l p H |M25425/male (* APPROVED PROTOCOL *) Dose Grmip ^ ^ 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665081 Continued from previous page Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665086 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed .LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : FATTY CHANGE, PERIPORTAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal 665086 Continued on the next page .... -928 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY a p H ||25425/male (* APPROVED PROTOCOL *) Dose Group : rf 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref 665086 Microscopic & Macroscopic Findings Continued from previous page Histopathology LUNGS : MACROPHAGES, ALVEOLAR, FOCAL, minimal. HEART : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. OPTIC NERVE NOT PRESENT, UNILATERAL. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE - 929Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing I j, Showing animal data for individual animals STUDY 5425/male (* APPROVED PROTOCOL *) Dose Group : jL 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665098 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -930- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing w 4ft Showing animal data for individual animals STUDY : m m 5425/male (* APPROVED PROTOCOL *) Dose Group 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665106 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. FATTY CHANGE, PERIPORTAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND -931 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing m. Mk Showing animal data for individual animals STUDY M25425/male (* APPROVED PROTOCOL *) Dose Group : \E 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 665121 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM,' PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND -932- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing m h Showing animal data for individual animals STUDY : f P l M 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group t r 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665130 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, mild. EYE(S ) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. URINARY BLADDER : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal 665130 Continued on the next page .... Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY M P I M 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group i 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665130 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665148 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665148 Continued on the next page .... - 934Company Sanitized. Does not contain TSCA CBI H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY ' B M W 5425/male {* APPROVED PROTOCOL *) Dose Group : TT 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 665148 Continued from previous page Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. PROSTATE : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH. NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -935 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing m ft Showing animal data for individual animals STUDY : M P I p25425/male (* APPROVED PROTOCOL * ) Dose Group : jC 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665149 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE( S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 936 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing mm Showing animal data for individual animals STUDY M 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group u 0 mg/kg Treatment: 0 mg/kg I Sex: Males Animal Ref Microscopic & Macroscopic Findings 665159 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -937- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________ DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY : U M | 2 5 4 2 5 /male {* APPROVED PROTOCOL *) Dose GzWfp :Dill 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 664,993 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE., SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, mild. FATTY CHANGE, PERIPORTAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 938 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing M Showing animal data for individual animals STUDY :Vm | 25425/male (* APPROVED PROTOCOL *) Dose Group ^ jlII 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 664995 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND -939 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose GrWPp Animal Ref 665033 Individual Animal Listing Showing animal data for individual animals [25425/male (* APPROVED PROTOCOL *) II 10 mg/kg Treatment: 10 mg/kg III Sex: Males Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : LIVER, THYROID GLAND 665053 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665053 Continued on the next page .... - 940Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Gr'f c Animal Ref 665053 Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) i I 10 mg/kg Treatment: 10 mg/kg III Sex: Males Microscopic & Macroscopic Findings Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665060 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665060 Continued on the next page .... -941 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing M Showing animal data for individual animals STUDY 25425/male (* APPROVED PROTOCOL *) Dose GrRzp: ill 10 mg/kg Treatment: 10 mg/kg III Sex: Males .Animal Ref Microscopic & Macroscopic Findings 665060 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. 665074 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665074 Continued on the next page .... -942- Company Sanitized. D o e s not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing m Showing animal data for individual animals |25425/male (* APPROVED PROTOCOL *) III 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665074 Continued from 'previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. No Microscopic Abnormality Observed : THYROID GLAND 665080 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665080 Continued on the next page .... -943 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________ _________DuPont-11418 Individual Animal Listing m ____g Showing animal data for individual animals STUDY : 25425/male (* APPROVED PROTOCOL *) Dose GrWfp: all 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665080 Continued from previous page Gross Pathology : Wo Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665128 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665128 Continued on the next page .... - 944Company Sanitized. Does not contain TSCA CBI H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals DSoTsUeDYGr| oWSp : I|II542105/mmga/lekg (* APPROVED Treatment: PROTOCOL *) 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665128 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 665131 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665131 Continued on the next page .... -945- Company Sanitized. Does not contain TSCA CBI 9H0--2D5a4y25G:aSvaugbechSrtoundiyciTnoRxaictistywithOne-GenerationReproduction Evaluations DuPont-11418 Individual Animal Listing 1 Showing animal data for individual animals STUDY f g m t 2 5 4 2 5 /male (* APPROVED PROTOCOL *) Dose Gj^up : ill 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665131 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665136 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665136 Continued on the next page .... -946- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________DuPont-11418 Individual Animal Listing ft STUDY gg Showing animal data for individual animals 25425/male (* APPROVED PROTOCOL *) Dose Group : III 10 mg/kg Treatment: 10 mg/kg III Sex: Males Animal Ref Microscopic & Macroscopic Findings 665136 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -947- Company Sanitized. Does not contain TSCA CBI H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing A Showing animal data for individual animals STUDY 25425/male (* APPROVED PROTOCOL *) Dose Group : v 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665035 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -948 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY f i p M 25425/male (* APPROVED PROTOCOL *) Dose GrOTrp V' 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665054 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE., THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, mild. No Microscopic Abnormality Observed : THYROID GLAND - 949 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 STUDY Dose G Animal Ref Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) 100 mg/kg Treatment: OO mg/kg V Sex: Males Microscopic & Macroscopic Findings 665073 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUSj PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND -950- Company Sanitized. Does not contain TSCA C B I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY : 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group ^ V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings ' 665089 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND -951 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals _i25425/male (* APPROVED PROTOCOL *) V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665103 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. FATTY CHANGE, PERIPORTAL, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. - 952 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665119 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE', SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 953 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY ^j25425/male (* APPROVED PROTOCOL *) Dose Group : V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665122 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON,. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC .NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 954- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals study (25425/male (* APPROVED PROTOCOL *) Dose Group ^ V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Retf Microscopic & Macroscopic Findings 665137 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND -955- Company Sanitized. Does not contain TSCA CBI /****>, H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY u 5425/male {* APPROVED PROTOCOL *) Dose Giroup : V 100 mg/kg Treatment: 100 mg/kg V Sex: Males .Animal Ref Microscopic Sc Macroscopic Findings 665143 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM., MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. No Microscopic Abnormality Observed : THYROID GLAND -956- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing M Showing animal data for individual animals STUDY f | M N 5425/male (* APPROVED PROTOCOL *) Dose Group : V 100 mg/kg Treatment: 100 mg/kg V Sex: Males Animal Ref Microscopic & Macroscopic Findings 665155 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM., MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND - -957 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 664999 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON,. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. PROSTATE : AGGREGATES, LYMPHOID, minimal. 664999 Continued on the next page .... - 958 - Company Sanitized. Does not contain TSCA CBI /``N H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY ^P25425/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 664999 Continued from previous page Histopathology : URINARY BLADDER : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, ORAL MUCOSA, minimal. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665002 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665002 Continued on the next page .... - 959- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________ DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animis _,25425/male (* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665002 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. FATTY CHANGE, PERIPORTAL, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. 665007 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665007 Continued on the next page .... -960- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ! Showing animal data for individual animals STUDY l j p P ^ 2 5 4 2 5 /male (* APPROVED PROTOCOL *) Dose g S u p : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665007 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. 665026 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665026 Continued on the next page -961 - Company Sanitized. Does not contain TSCA CBI r\ H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ft___ Showing animal data for individual animals STUDY p H I 2 5 4 2 5 /male (* APPROVED PROTOCOL *) Dose Group !vll 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665026 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. HEART : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, mild. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. PROSTATE : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, TURBINATES, minimal. 665026 Continued on the next page -962- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________ DuPont-11418 Individual Animal Listing f ___ Showing animal data for individual animals STUDY ft^p25425/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665026 Continued from previous page Hi stopathology No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE,. SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYEIS).WITH .QRTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665027 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665027 Continued on the next page - 963 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 25425/male (* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665027 Continued from previous page Histopathology : LIVER : DEGENERATION, HEPATOCELLULAR, FOCAL, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. LUNGS : MACROPHAGES, ALVEOLAR, FOCAL, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, mild. NECROSIS, LYMPHOID, minimal. THYMUS : HEMORRHAGE, mild. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. PROSTATE : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, TURBINATES, mild. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW - 964Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY1 Dose Group Individual Animal Listing k Showing animal data for individual animals |?5425/male (* APPROVED PROTOCOL *). TI 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665031 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S} WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. No Microscopic Abnormality Observed : THYROID GLAND -965- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __________ DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 5425/male {* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665062 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM., MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. -966- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animis STUDY P B P a p 25425/male (* APPROVED PROTOCOL *) Dose Group II-1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665067 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : . INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND HYPERTROPHY, FOLLICULAR CELL, minimal. -967- Company Sanitized. Does not contain TSCA CBI /^**W*K ""N, H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______ DuPont-11418 Individual Animal Listing jgj Showing animal data for individual animals STUDY J p H I 25425/male (* APPROVED PROTOCOL *) Dose Group i v l l 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665082 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM,. PANCREAS , CECUM, .COLON, .RECTUM,.MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. AGGREGATES, LYMPHOID, minimal. CYST, TUBULAR, mild. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. MANDIBULAR LYMPH NODE : LEUKOCYTOSIS, PLASMA CELL, MEDULLARY, mild. THYMUS : HEMORRHAGE, minimal. 665082 Continued on the next page .... - 968- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing aa Showing animal data for individual animals STUDY H | BH25425/male (* APPROVED PROTOCOL *) Dose Group I v I I 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665082 Continued from previous page Histopathology : THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665095 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665095 Continued on the next page .... - 969- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animis STUDY 25425/male {* APPROVED PROTOCOL *) Dose Grroouupp : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665095 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND,'PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665096 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665096 Continued on the next page .... -970- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______ _____________ DuPont-11418 Individual Animal Listing Showing animal data for individual animis STUDY B P j P 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665096 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. AGGREGATES, LYMPHOID, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. EYE(S ) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, mild. URINARY BLADDER : AGGREGATES, LYMPHOID, minimal. 665096 Continued on the next page .... -971 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing 4ft Showing animal data for individual animals STUDY | H H | 5 4 2 5/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665096 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665107 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRA-IN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665107 Continued on the next page - 972Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Ip J Individual Animal Listing Showing animal data for individual animis STUDY 5425/male (* APPROVED PROTOCOL *) Dose Gr? II 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Hales DuPont-11418 Animal Ref Microscopic & Macroscopic Findings 665107 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. PROSTATE : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -973 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ Showing animal data for individual animals STUDY | W H ^P25425/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665112 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER,- KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. No Microscopic Abnormality Observed : THYROID GLAND -974- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 STUDY 1 Dose Gl Individual Animal Listing A Showing animal data for individual animals 25425/male (* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665120 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : KIDNEYS : DILATATION, BILATERAL, PELVIS, LEFT MODERATE RIGHT SEVERE. No Macroscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE .Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, mild. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. TRACHEA : INFLAMMATION, FOCAL, minimal. 665120 Continued on the next page .... - 975- Company Sanitized. Does not co n ta in T S C A C B I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing J A Showing animal data for individual animals STUDY M B d p 2 5425/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665120 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, ESOPHAGUS, PHARYNX/LARYNX, .EYE.(.SI WITH.OPTIC. NERVE., SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665138 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665138 Continued on the next page - 976- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY l p B B # 2 5 4 2 5 / m a l e <* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665138 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665146 Terminal Sacrifice Killed on Day : 127 Exposure Group ; recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minimal. 665146 Continued on the next page .... -977 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing m STUDY ^ Showing animal data for individual animals ^p5425 / m a l e {* APPROVED PROTOCOL *) Dose Group : vll 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665146 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. 665152 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal 665152 Continued on the next page .... - 978Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY M25425/male (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665152 Continued from previous page Histopathology : KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, mild. EYE(S) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. NOSE : INFLAMMATION, VOMERONASAL ORGAN, minimal. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW - 979Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Pj Showing animal data for individual animals STUDY { ! ( 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group ^ v l l 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665158 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON,. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hi stopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. 'THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. -980- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals 5425/male (* APPROVED PROTOCOL *) VII 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic & Macroscopic Findings 665160 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : - LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. PROSTATE : AGGREGATES, LYMPHOID, mild. 665160 Continued on the next page .... -981 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing p Showing animal data for individual animals STUDY C a p i M w 5425/male (* APPROVED PROTOCOL *) Dose Greup : V l I 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Animal Ref Microscopic &. Macroscopic Findings 665160 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665162 Terminal Sacrifice Killed on Day : 92 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER,_ KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 665162 Continued on the next page - 982Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY J p B ^ p 2 5 4 2 5 / m a l e (* APPROVED PROTOCOL *) Dose Group : VII 1000 mg/kg Treatment: 1000 mg/kg VII 'Sex: Males Animal Ref 665162 Microscopic & Macroscopic Findings Continued from previous page Histopathology : LIVER : NECROSIS, FOCAL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, mild. FATTY CHANGE, PERIPORTAL, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, mild. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. PROSTATE : AGGREGATES, LYMPHOID, mild. URINARY BLADDER : AGGREGATES, LYMPHOID, minimal. EPIDIDYMIDES : AGGREGATES, LYMPHOID, minimal. NOSE : INFLAMMATION, NASOLACRIMAL DUCT, mild. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 665162 Continued on the next page .... - 983 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY U Dose G3rrobup Animal Ref 665162 Individual Animal Listing Showing animal data for individual animis l 5425/male (* APPROVED PROTOCOL *) II 1000 mg/kg Treatment: 1000 mg/kg VII Sex: Males Microscopic & Macroscopic Findings Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, TESTES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE *** Listing Complete *** -984- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals iemal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg-/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665174 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL.CORD, .STOMACH,. DUODENUM, .JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. PHARYNX/LARYNX : DEGENERATION, MYOFIBER, mild. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, BILATERAL. 665174 Continued on the next page .... - 985 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Qne-Generation Reproduction Evaluations - DuPont-11418 STUDY _ Dose Group Animal Ref 665174 Individual Animal Listing .Showing animal data for individual animals __ |femal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Microscopic & Macroscopic Findings Continued from previous page Histopathology : VAGINA : ESTRUS STAGE: METESTRUS. 665178 No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology. : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665178 Continued on the next page -986- Company Sanitized. D o e s not co n tain T S C A C B I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing t Showing animal data for individual animals STUDY | P S H ^ f e m a l (* APPROVED PROTOCOL *) Dose Group : II l^ng/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665178 Continued from previous page Gross Pathology No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA : ESTRUS STAGE: ESTRUS. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 665178 Continued on the next page .... -987- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^Showing animal data for individual animals STUDY { p i M f e m a l (* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665178 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665189 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND - 988 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing [Showing animal data for individual animals STUDY femal (* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref 665197 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665201 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665201 Continued on the next page .... -989- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Grbup Animal Ref Individual Animal Listing Showing animal data for individual animals __ emal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Microscopic & Macroscopic Findings 665201 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665204 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND., THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665204 Continued on the next page .... , - 990Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________ DuPont-11418 STUDY Dose Group Individual Animal Listing howing animal data for individual animals emal {* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665204 Continued from previous page Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665211 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. 665211 Continued on the next page .... -991 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing * __ Showing animal data for individual animals STUDY p E e m a l <* APPROVED PROTOCOL *) Dose Group : II ^mg / k g Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665211 Continued from previous page Histopathology LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. PITUITARY GLAND : CYST, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, BILATERAL. VAGINA : ESTRUS STAGE: PROESTRUS. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665221 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : PITUITARY GLAND : LARGE, mild. 665221 Continued on the next page - 992Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY _ Dose Group Individual Animal Listing I fkShowing animal data for individual animals emal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665221 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LUNGS : HEMORRHAGE, ALVEOLAR, minimal. PARATHYROID GLANDS : MISSING. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. SKIN : DERMATITIS, FOCAL, minimal. VAGINA : ESTRUS STAGE: METESTRUS. 665221 Continued on the next page .... - 993 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals emal (* APPROVED PROTOCOL *) II 0"mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665221 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ORGANS NOT EXAMINED: PARATHYROID GLANDS 665225 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665225 Continued on the next page -994- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing JP** ^jfcShowing animal data for individual animals STUDY U I H M H f l B f e m a l (* APPROVED PROTOCOL *) Dose G r o u p T l l O m g / k g Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665225 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT,'STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. BRAIN : AGGREGATES, LYMPHOID, CHOROID PLEXUS, mild. THYMUS : HEMORRHAGE, mi1d . EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA : ESTRUS STAGE: ESTRUS. NOSE : INFLAMMATION, ORAL MUCOSA, minimal. 665225 Continued on the next page .... - 995- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ __________________DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals ___ emal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665225 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665228 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665228 Continued on the next page .... -996- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY _ Dose Group Individual Animal Listing Showing animal data for individual animals ifemal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665228 Continued from previous page Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665230 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : CERVIX : DISCOLORATION, WHITE, FIRM, 4 MM DIA.. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. 665230 Continued on the next page .... -997- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing afcShowing animal data for individual animals STUDY d m B H g f e m a 1 (* APPROVED PROTOCOL *) Dose Group :^ ^ I ^ m g / k g Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665230 Continued from previous page Histopathology LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. PITUITARY GLAND : CYST, mild. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. VAGINA : ESTRUS STAGE: PROESTRUS. URINARY BLADDER : MISSING. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ORGANS NOT EXAMINED: URINARY BLADDER -998 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing iShowing animal data for individual animals STUDY I g p p B M H p e m a l (* APPROVED PROTOCOL *) Dose G r a u p T l I ^ m g / k g Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665256 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665260 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665260 Continued on the next page .... -999- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ ^ ^ j S h o w i n g animal data for individual animals STUDY ^ | | H H ^ p f e m a l (* APPROVED PROTOCOL *) Dose Group :: II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665260 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM,. NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665271 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : ; LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665271 Continued on the next page .... - 1000 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ _____________ DuPont-11418 STUDY Dose Group Individual Animal Listing [Showing animal data for individual animals _____ emal (* APPROVED PROTOCOL *) II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665271 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA : ESTRUS STAGE: METESTRUS. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE , -1001 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY ^ ^ p e m a l {* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665276 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665278 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665278 Continued on the next page .... - 1002- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ;howing animal data for individual animals STUDY emal (* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665278 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. THYMUS : HEMORRHAGE, minimal. VAGINA : ESTRUS STAGE: PROESTRUS. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE - 1003 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing _____ ^Showing animal data for individual animals STUDY K f e m a l (* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665317 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 665317 LIVER : FATTY CHANGE, PERIPORTAL, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. SPINAL CORD : MISSING. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, PARATHYROID GLANDS : MISSING. VAGINA : ESTRUS STAGE: PROESTRUS Continued on the next page .... SINUS, minimal. - 1004 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing l^Showincr animal data for individual animals STUDY H M H f e m a l (* APPROVED PROTOCOL *) Dose G * u p : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665317 Continued from previous page Hist opatho1ogy No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE ORGANS NOT EXAMINED: SPINAL CORD, PARATHYROID GLANDS 665319 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665319 Continued on the next page - 1005 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________ DuPont-11418 Individual Animal Listing g ^ Showing animal data for individual animals STUDY ^ ^ 0 P | B M f e m a l (* APPR0VED PROTOCOL *) Dose g H ^ p : II U mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665319 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. FATTY CHANGE, PERIPORTAL, minimal. MANDIBULAR LYMPH NODE : HYPERPLASIA, LYMPHOID, mild. THYMUS : HEMORRHAGE, minimal. TRACHEA : INFLAMMATION, minimal. VAGINA : ESTRUS STAGE: METESTRUS. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, ESOPHAGUS, 665319 Continued on the next page .... - 1006 - Company Sanitized. Does not contain TSCA CBi /****>, H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ ^ ^ ^ S h o w i n g animal data for individual animals STUDY U p H f P f e m a l (* APPROVED PROTOCOL *) Dose Group : II 0 mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings 665319 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665323 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL. GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND - 1007 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY :emal (* APPROVED PROTOCOL *) Dose Group II mg/kg Treatment: 0 mg/kg II Sex: Females Animal Ref Microscopic & Macroscopic Findings S65327 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND - 1008 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ ^ ^ I l K h o w i n g animal data for individual animals CfmSTUDY 1 B f e m a l (* APPROVED PROTOCOL *) Dose Giroup :: IV lu mg /kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665182 Terminal Sacrifice Killed on Day. : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1009 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing _____ ^Showing animal data for individual animals STUDY m J B B H B B ^ p e m a l (* APPROVED PROTOCOL *) Dose Group: IV lu mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665215 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, mild. No Microscopic Abnormality Observed : THYROID GLAND - 1010- Company Sanitized. Does not contain TSCA CBt H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________________ DuPont-11418 STUDY 1 Dose Gi Individual Animal Listing ^^^^^ S h o w i n g animal data for individual animals f e m a l (* APPROVED PROTOCOL *) ! l V l ^ ^ m g / k g Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665236 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL' GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. No Microscopic Abnormality Observed : THYROID GLAND - 1011 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing i * ^ ^ ^ ^^ifcShowing animal data for individual animals STUDY U p B B H H H H p e m a l {* APPROVED PROTOCOL *) Dose G r o u p - I V 10 mg/kg Treatment: 10 mg/kg IV Sx: Females Animal Ref Microscopic & Macroscopic Findings 665239 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1012- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing J^Showing animal data for individual animals STUDY emal (* APPROVED PROTOCOL *) Dose G * u p : IV 10 mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic ix Macroscopic Findings 665241 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1013- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing fllP^^^^^JBShowing animal data for individual animals STUDY K p B B H B H K f emal (* APPROVED PROTOCOL *) Dose Group! IV lu mg /kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665268 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1014- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing _J^Showing animal data for individual animals STUDY emal (* APPROVED PROTOCOL *) Dose Gr^up^: iv l u mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665277 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : LIVER, THYROID GLAND 665308 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART,. SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665308 Continued on the next page .... -1015- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing animal data for individual animals STUDY ^ p e r n a l (* APPROVED PROTOCOL *) Dose Group : IV 10mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref 665308 Microscopic & Macroscopic Findings Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND 665324 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665324 Continued on the next page .... - 1016- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals femal (* APPROVED PROTOCOL *) mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665324 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 665332 No Microscopic Abnormality Observed : LIVER, THYROID GLAND Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic. Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, .SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665332 Continued on the next page .... - 1017- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Individual Animal Listing fp ( ^ Showing animal data for individual animals STUDY emal (* APPROVED PROTOCOL *) Dose Group : IV I0 mg/kg Treatment: 10 mg/kg IV Sex: Females Animal Ref Microscopic & Macroscopic Findings 665332 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND DuPont-11418 -1018- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing P " ^ Showing animal data for individual animals STUDY l S P H H H H p f e m a l {* APPROVED PROTOCOL *) Dose Graxp: VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665170 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : NECROSIS, FOCAL, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1019- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^^fehowing animal data for individual animals STUDY M j m m ^ ^ e m a l {* APPROVED PROTOCOL *) Dose Group :.VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665199 Terminal Sacrifice Killed on Day : 93 Esqposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, mild. No Microscopic Abnormality Observed : THYROID GLAND -1020 - Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing a ________ ^Showing animal data for individual animals STUDY ^ p B B B B H K e m a l (* APPROVED PROTOCOL *) Dose Group : VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665238 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : FATTY CHANGE, MEDIAN CLEFT, mild. s INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1021 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY I p H H B B H V p e m a l {* APPROVED PROTOCOL *} Dose Group : VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665250 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1022 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing r. ^ b o w i n g animal data for individual animals STUDY m P P M I g p e m a l (* APPROVED PROTOCOL *) Dose Group : VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665251 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1023 - Company Sanitized. Does not contain T SC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group VI 1 Individual Animal Listing Showing animal data for individual animals Rental (* APPROVED PROTOCOL *) mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665259 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1024- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing howing animal data for individual animals emal (* APPROVED PROTOCOL *) mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665295 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1025 - Company Sanitized. Does not contain TSCA GBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 STUDY Dose Group Individual Animal Listing [Showing animal data for individual animals :emal (* APPROVED PROTOCOL *) VI 1(70 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665300 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1026 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^^^^fcshowing animal data for individual animals STUDY I P V ! B H B I p f e m a l (* APPROVED PROTOCOL *) Dose Group : VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665340 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1027 - Company Sanitized. Does not contain TSCA CBI /**% H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 Individual Animal Listing Showing animal data for individual animals STUDY M ^ B E e m a l (* APPROVED PROTOCOL *) Dose Group : VI 100 mg/kg Treatment: 100 mg/kg VI Sex: Females Animal Ref Microscopic & Macroscopic Findings 665341 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND - 1028 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing showing animal data for individual animals _ emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665183 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, minimal. LEUKOCYTOSIS, PLASMA CELL, MEDULLARY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA : ESTRUS STAGE: METESTRUS. 665183 Continued on the next page .... -1029 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ ^ S howing animal data for individual animals STUDY B p B H B H H d p E e m a l (* APPROVED PROTOCOL *) Dose Group : VIII 1 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665183 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665200 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665200 Continued on the next page .... - 1030 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 STUDY] Dose roup Animal Ref Individual Animal Listing howing animal data for individual animals emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Microscopic & Macroscopic Findings 665200 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. HEART : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYMUS : HEMORRHAGE, minimal. VAGINA : ESTRUS STAGE: PROESTRUS. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE -1031 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study to Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Animal Ref VIII Individual Animal Listing Showing animal data for individual animals Eemal (* APPROVED PROTOCOL *) 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Microscopic & Macroscopic Findings 665209 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665229 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665229 Continued on the next page .... - 1032 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing f ______ ^ S howing animal data for individual animals STUDY I H B H B H Q p e m a l (* APPROVED PROTOCOL *) Dose G ^ ^ ^ t VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665229 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ECTOPIC THYMUS TISSUE. 665234 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665234 Continued on the next page .... - 1033 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing |Showing animal data for individual animals emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665234 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : CHRONIC PROGRESSIVE NEPHROPATHY, minimal. THYMUS : HEMORRHAGE, minimal. VAGINA : ESTRUS STAGE: ESTRUS. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE - 1034 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing P ^ ^ ^ ^ ^ J S h o w i n g animal data for individual animals STUDY I p l H I l H B i e m a l (* APPROVED PROTOCOL *) Dose (Jroup : VIII lOOO mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665237 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665242 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665242 Continued on the next page .... - 1035 - Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________ DuPont-11418 Individual Animal Listing W ^ Showing animal data for individual animals STUDY H p H H B B H j j p f e m a l (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665242 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed :, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : DUODENUM : MISSING. THYMUS : HEMORRHAGE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. VAGINA : ESTRUS STAGE: ESTRUS. No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN,AORTA, BRAIN, SPINAL CORD, STOMACH, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665242 Continued on the next page .... - 1036 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ ^ ^ ^ ^ ^ s h o w i n g animal data for individual animals STUDY I p i B B H ^ p f e m a l {* APPROVED PROTOCOL *} Dose c K u p : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665242 Continued from previous page Histopathology : ORGANS NOT EXAMINED: DUODENUM 665261 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. VAGINA : ESTRUS STAGE: PROESTRUS. 665261 Continued on the next page .... - 1037 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Individual Animal Listing howing animal data for individual animis emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665261 Continued from previous page Histopathology : NOSE : INFLAMMATION, TURBINATES, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665275 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665275 Continued on the next page .... - 1038 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 r Individual Animal Listing ^S h o w i n g animal data for individual animals STUDY U i e m a l (* APPROVED PROTOCOL *) Dose Group : V I I I 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665275 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology No Microscopic Abnormality Observed : THYROID GLAND 665282 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665282 Continued on the next page .... - 1039 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^Showing animal data for individual animals STUDY (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic Sc Macroscopic Findings 665282 Continued from previous page Histopathology No Microscopic Abnormality Observed : THYROID GLAND 665288 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. ' - 1040 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________ DuPont-11418 STUDY Dose Group Individual Animal Listing Showing animal data for individual animals emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665291 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : AGGREGATES, LYMPHOID, minimal. LUNGS : HEMORRHAGE, ALVEOLAR, minimal. PANCREAS : AGGREGATES, LYMPHOID, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. 665291 Continued on the next page .... /****\ - 1041 - Company Sanitized. Does not contain TSCA CBi H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing ^ Showing animal data for individual animals STUDY M B t P f e m a l (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Kef Microscopic & Macroscopic Findings 665291 Continued from previous page Histopathology : SKIN : DERMATITIS, FOCAL, minimal. VAGINA : ESTRUS STAGE: PROESTRUS. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665299 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is 'signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665299 Continued on the next page .... - 1042 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing IShowing animal data for individual animals v u :STUDY _ Dose Group [femal (* APPROVED PROTOCOL *) 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665299 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND 665303 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 665303 Continued on the next page .... - 1043 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing (Showing animal data for individual animals STUDY g B B Q p E e m a l (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665303 Continued from previous page Histopathology THYROID GLAND : HYPERTROPHY, FOLLICULAR CELL, minimal. 665310 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : LIVER : DEFORMITY, RIGHT, LOBE. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LUNGS : HEMORRHAGE, ALVEOLAR, minimal 665310 Continued on the next page .... - 1044 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchxonic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 Individual Animal Listing [Showing animal data for individual animals STUDY (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665310 Continued from previous page Histopathology : PANCREAS : AGGREGATES, LYMPHOID, minimal. THYMUS : HEMORRHAGE, minimal. VAGINA : ESTRUS STAGE: METESTRUS. No Microscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665326 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665326 Continued on the next page .... - 1045 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________ DuPont-11418 STUDY Dose Group Individual Animal Listing howing animal data for individual animals emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665326 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE{S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR, minimal. THYMUS : CYST, EPITHELIAL, mild. HEMORRHAGE, minimal. TRACHEA : AGGREGATES, LYMPHOID, mild. EYE(S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, UNILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. VAGINA : ESTRUS STAGE: ESTRUS. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, 665326 Continued on the next page .... - 1046 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group Animal Ref VIII Individual Animal Listing [Showing animal data for individual animals pernal (* APPROVED PROTOCOL *) 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Microscopic & Macroscopic Findings 665326 Continued from previous page Histopathology : No Microscopic Abnormality Observed : ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 665328 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID.GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : THYROID GLAND - 1047 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group VIII Individual Animal Listing Showing animal data for individual animals femal (* APPROVED PROTOCOL *) 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665333 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy '. Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LUNGS : HEMORRHAGE, ALVEOLAR, minimal. THYMUS : HEMORRHAGE, minimal. EYE(S ) WITH OPTIC NERVE : INFLAMMATION, PERIOCULAR, UNILATERAL, minimal. VAGINA : ESTRUS STAGE: PROESTRUS. NOSE : INFLAMMATION, TURBINATES, moderate, (gastric vomitus). INFLAMMATION, SINUS, mild, maxillary. 665333 Continued on the next page .... - 1048 - f Com pany Sanitized. D oes riot contain T S C A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 r Individual Animal Listing ^Sh o w i n g animal data for individual animals STUDY m ^ P f e m a l (* APPROVED PROTOCOL *) Dose Group : VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665333 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE) , OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 665335 Terminal Sacrifice Killed on Day : 127 Exposure Group : recov Animal is signed off from necropsy Gross Pathology : UTERUS : DILATATION, HORNS. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665335 Continued on the next page - 1049 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchionic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Gbup VIII Individual Animal Listing (Showing animal data for individual animals [femal (* APPROVED PROTOCOL *) 000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665335 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE (S ) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : VAGINA : ESTRUS STAGE: PROESTRUS. No Microscopic Abnormality Observed : THYROID GLAND, UTERUS 665337 Terminal Sacrifice Killed on Day : 93 Exposure Group : subch Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 665337 Continued on the next page .... - 1050 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 /* * * " N . STUDY Dose Group Individual Animal Listing Showing animal data for individual animals emal (* APPROVED PROTOCOL *) VIII 1000 mg/kg Treatment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665337 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, VAGINA, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : AGGREGATES, LYMPHOID, mild. THYMUS : HEMORRHAGE, minimal. PARATHYROID GLANDS : MISSING. EYE{S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT, BILATERAL. MISSING, UNILATERAL, LENS. VAGINA : ESTRUS STAGE: PROESTRUS. NOSE : INFLAMMATION, TURBINATES, minimal. 665337 Continued on the next page .... - 1051 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 STUDY Dose Group VIII Individual Animal Listing (Showing animal data for individual animals pernal (* APPROVED PROTOCOL *) 000 mg/kg Tretment: 1000 mg/kg VIII Sex: Females Animal Ref Microscopic & Macroscopic Findings 665337 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW ORGANS NOT EXAMINED: PARATHYROID GLANDS *** Listing Complete *** - 1052 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX O INDIVIDUAL ANIMAL MICROSCOPIC OBSERVATIONS LISTING INDIVIDUAL ANIMALS AFFECTED - 1053 Com pany Sanitized. Does not contain T S C A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg /kg I III V VII ) DuPont-11418 DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. HYPERTROPHY, HEPATOCELLULAR, CENTRILOBULAR. FATTY CHANGE, PERIPORTAL. (10) (10) (10) (10) 665033 665162 665015 664993 665035 664999 665016 664995 665054 665026 665047 665053 665073 665027 665049 665060 665089 665082 665068 665074 665103 665096 665070 665080 665119 665107 665076 665128 665122 665120 665086 665131 665137 665152 665130 665136 665143 665160 665148 665155 665162 664999 665026 665027 665082 665096 665107 665152 665160 665162 665015 664993 665073 665162 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1054 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VIT DuPont-11418 DIGESTIVE SYSTEM LIVER FATTY CHANGE, PERIPORTAL. ( FATTY CHANGE, MEDIAN CLEFT. DEGENERATION, HEPATOCELLULAR, FOCAL. (10) (10) (10) (10) 665016 665103 665047 665143 665068 665076 665086 665130 665070 664995 665089 665162 665148 665074 665103 665128 665122 665137 665155 665027 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1055 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM PANCREAS NO ABNORMALITY DETECTED INFLAMMATION, FOCAL. (10) 665015 665016 665047 665049 665070 665076 665086 665130 665148 665068 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A C 8 I - 1056 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Micrbscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (9) 665015 665016 665047 665049 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A C B i - 1057 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM STOMACH (10) NO ABNORMALITY DETECTED I 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1058 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS ' TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-114 18 DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED 1 (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1059 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI -1060 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A CBI -1061 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 ' 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1062 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 itig/hg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1063 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A CBI - 1064 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-114 18 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI -1065 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED CHRONIC PROGRESSIVE NEPHROPATHY. HYDRONEPHROSIS, UNILATERAL. CYST, TUBULAR. AGGREGATES, LYMPHOID. (10) 665049 665076 665015 665016 665047 665068 665086 665130 665148 665070 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 665162 665026 665082 665096 665152 665160 665120 665082 664999 665082 665096 665107 Company Sanitized. Does not contain T SC A CBI - 1066 - H90--2D54a2y5G: aSvuabgechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations____________________________________ . Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS > TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. (10) 665015 665016 665047 665049 665068 665070 665086 665148 665076 665130 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665026 665027 665082 665107 665120 665152 665160 664999 665096 665162 Company Sanitized. Does not contain T SC A CBI - 1067 - H90--2D5a42y5G:aSvuagbechSrtoundiyciTnoRxiactistywith Qne-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Lasting Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED MACROPHAGES, ALVEOLAR, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR. (10) 665015 665049 665068 665148 665076 665086 665016 HEMORRHAGE, ALVEOLAR. 665047 665070 665130 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665026 665107 665120 665162 665027 664999 665096 665160 665082 665096 665152 Company Sanitized. Does not contain T S C A CBI - 1068 - H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywithOne-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 RESPIRATORY SYSTEM , TRACHEA NO ABNORMALITY DETECTED INFLAMMATION, FOCAL. (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665152 665160 665162 665120 Com pany Sanitized. Does not contain T S C A CBI - 1069 - )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________ ___________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII RESPIRATORY SYSTEM PHARYNX/LARYNX (10) NO ABNORMALITY DETECTED 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 i i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A CBI - 1070 - 9H0--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 RESPIRATORY SYSTEM NOSE NO ABNORMALITY DEJECTED INFLAMMATION, TURBINATES. INFLAMMATION, VOMERONASAL ORGAN. INFLAMMATION, ORAL MUCOSA. INFLAMMATION, NASOLACRIMAL DUCT. (10) 665015 665049 665068 665076 665086 665130 665148 665070 665016 665047 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665082 665096 665107 665120 665160 665162 665026 665027 665152 664999 665162 Company Sanitized. Does not contain T S C A CBI -1071 - 9H0--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions ' Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DuPont-11418 CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. (10) 665015 665016 665047 665049 665068 665070 665076 665130 665148 665086 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665027 665082 665096 665107 665120 665152 665160 665162 665026 Company Sanitized. Does not contain T SC A CBI -1072 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 CARDIOVASCULAR SYSTEM AORTA (10) NO ABNORMALITY DETECTED 665015 665016 665047 665049 665068 665070 665076 665086 665130 !665148 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1073 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1074 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED HEMORRHAGE. * (10) 665016 665070 665076 665130 665015 665047 665049 665068 665086 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665107 665160 664999 665026 665027 665082 665096 665120 665152 665162 Company Sanitized. Does not contain T S C A CBI - 1075 - )) H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED NECROSIS, LYMPHOID. LEUKOCYTOSIS, PLASMA CELL, MEDULLARY. ERYTHROCYTOS IS/ ERYTHROPHAGOCYTOS IS, SINUS . (10) 665015 665016 665047 665049 665070 665076 665130 665148 665068 665086 1 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665096 665107 665120 665152 665160 665027 665082 665026 665027 665162 Company Sanitized. Does not contain T S C A C 8I - 1076 - ) ~) H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_____________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1077 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________ ________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED * (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1078 - ) ) .) H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED CYST. (10) 665015 665016 665047 665049 665068 665076 665086 665130 665148 665070 Figure in parentheses is number of animals microscopically examined for this tissue .The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1079 - H90--2D5a4y25G: aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. (10) (10) (10) (10) 665015 664993 665035 665016 664995 665054 665047 665033 665073 665049 665053 665089 665068 665074 665119 665076 665080 665122 665086 665128 665137 665130 665131 665143 665148 665136 665155 665070 665060 665103 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a 'number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1080 - H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations_____ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 ENDOCRINE SYSTEM PARATHYROID GLANDS' . NO ABNORMALITY DETECTED (9) 665015 665016 665047 665049 665068 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI -1081 - H90--2D5a4y25G:aSvuabgechSrtoundiyc TinoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS > TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED ADRENAL MEDULLA MISSING. (10) 665015 665016 665049 665068 665070 665076 665086 665130 665148 665047 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1082 - )) . H90--2D5a42y5G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg /kg I III V VII ) DuPont-11418 NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1083 - H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxiactistywith One-GenerationReproduction Evaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1084 - ) )) H90--2D5a42y5G: aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations________________ __________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (9) 665015 665016 665047 665049 665068 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A CBI - 1085 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (9) 665015 665016 665047 665049 665068 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Com pany Sanitized. Does not contain T S C A CBI - 1086 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS ' TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1087 - H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI - 1088 - )) ) H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED 1 (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T SC A CBI - 1089 - 9H0--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Micrpscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM EPIDIDYMIDES NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. (10) 665015 665049 665068 665070 665076 665086 665016 665047 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665027 665096 665120 665152 665160 664999 665026 665082 665107 665162 Company Sanitized. Does not contain T SC A CBI -1090 - ) ) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions , Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. (10) 665016 665086 665130 665015 665047 665049 665068 665070 665076 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665082 665096 665120 665152 664999 665026 665027 665107 665160 665162 Company Sanitized. Does not contain T S C A CBI -1091 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM SEMINAL VESICLES NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 Company Sanitized. Does not contain T S C A CBI -1092 - H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations , Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice 1 1 LESIONS . TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DuPont-11418 CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (10) 665015 665016 665047 665049 665068 665070 665076 665086 665130 665148 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665096 665107 665120 665152 665160 665162 1 Com pany Sanitized. Does not contain T SC A CBI - 1093 - )_ > ) H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII SPECIAL SENSES SYSTEM EYE(S) WITH OPTIC NERVE NO ABNORMALITY DETECTED (10) 665016 665047 665068 665070 665148 OPTIC NERVE NOT PRESENT, UNILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL. ATROPHY, RETINAL, UNILATERAL. 665070 665076 665086 665148 665049 665076 665086 665130 665015 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 664999 665026 665027 665082 665107 665120 665160 665162 665107 665096 665152 Company Sanitized. Does not contain T S C A CBI -1094 - H90--2D5a42y5G:aSvuagbechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM LIVER NO ABNORMALITY DETECTED NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, PERIPORTAL. FATTY CHANGE, MEDIAN CLEFT. < (10) (10) (10) (10) 665221 665277 665242 665324 665310 665333 665170 665174 665182 665170 665183 665178 665215 665199 665200 665211 665236 665238 665234 665225 665239 665250 665261 665230 665241 665251 665291 665271 665268 665259 665326 665278 665308 665295 665337 665319 665332 665300 665340 665341 665174 665183 665178 665225 665278 665317 665319 665174 665236 665238 665230 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBt - 1095 - H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation ReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected > Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 DIGESTIVE SYSTEM LIVER FATTY CHANGE, MEDIAN CLEFT. (10) (10) 665319 (10) (10) Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1096 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM PANCREAS '` NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID. (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665326 665333 665337 665291 665310 Company Sanitized. Does not contain T SC A CBI - 1097 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T SC A CBI - 1098 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI - 1099 - H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg /kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 665183 665200 665234 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -1100- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI -1101 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg /kg mg /kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A CBI - 1102- ) H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywithOne-Generation ReproductionEvaluations rotions in Female Eats Listing Individua. Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS > TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg II IV VI VIII ) DuPont-11418 DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI - 1103- H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg II IV VI VIII ) DuPont-11418 DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A CBI - 1104- H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI - 1105- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with Ope-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals A-ffected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -1106- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED CHRONIC PROGRESSIVE NEPHROPATHY. AGGREGATES, LYMPHOID. (10) 665221 665230 665271 665278 665317 665319 665174 665178 665225 665211 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665242 665261 665310 665326 665333 665234 665200 665291 665337 Company Sanitized. Does not contain T SC A CBI - 1107- H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg /kg II IV VI VIII ) DuPont-11418 URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED (9) 665174 665178 665211 665221 665225 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a numbet indicates the lesion specified was not identified 1 (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A CBI - 1108- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 RESPIRATORY SYSTEM LUNGS NO ABNORMALITY DETECTED GO) 665278 665319 INFLAMMATION, SUBACUTE/CHRONIC, PERIVASCULAR. HEMORRHAGE, ALVEOLAR. 665211 665230 665174 665178 665211 665221 665225 665271 665317 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified GO) 665183 665200 665234 665242 665261 665337 665326 665291 665310 665333 Company Sanitized. Does not contain T SC A O 03 H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-Generation ReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED INFLAMMATION. AGGREGATES, LYMPHOID. (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665333 665337 665326 Company Sanitized. Does not contain T SC A CBI -1110- ) H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations____________________________________________________ DuPont-11418 Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED DEGENERATION, MYOFIBER. (10) 665178 665211 665221 665225 665230 665271 665278 665317 665319 665174 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -m i - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________ __ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED INFLAMMATION, TURBINATES. (10) 665174 665178 665211 665221 665230 665271 665278 665317 665319 INFLAMMATION, SINUS. INFLAMMATION, ORAL MUCOSA. 665225 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665291 665310 665326 665261 665333 665337 665333 Company Sanitized. Does not contain T SC A CBI - 1112- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observatiens in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice 1 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg II IV VI VIII DuPont-11418 CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED INFLAMMATION, SUBACUTE/CHRONIC. (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665234 665242 665261 665291 665310 665326 665333 665337 665200 Com pany Sanitized. Does not contain T S C A CBI -1113- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 1 Com pany Sanitized. Does not contain T SC A CBI -1114- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI -1115 - H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS NO ABNORMALITY DETECTED HEMORRHAGE. (10) 665174 665211 665221 665230 665317 665178 665225 665271 665278 665319 CYST, EPITHELIAL. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665261 665200 665234 665242 665291 665310 665326 665333 665337 665326 Company Sanitized. Does not contain T SC A CBI -1116- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED LEUKOCYTOSIS, PLASMA CELL,'MEDULLARY. HYPERPLASIA, LYMPHOID. ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS. (10) 665174 665178 665211 665221 665225 665230 665271 665278 665319 665317 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665200 665234 665242 665261 665291 665310 665326 665333 665337 665183 665183 Company Sanitized. Does not contain T SC A CBI -1117- ). ) H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions , Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII > DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 1 Company Sanitized. Does not contain T SC A CBI - 1118- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A O CD ) H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED (10) 665174 665178 665221 665225 665271 665278 665317 665319 CYST. 665211 665230 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A CBI - 1120- )) H90--2D54a2y5G: aSvuabgechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII } DuPont-11418 ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. (10) (10) (10) (10) 665174 665182 665170 665200 665178 665215 665199 665234 665211 665236 665238 665261 665221 665239 665250 665291 665225 665241 665251 665310 665230 665268 665259 665326 665271 665277 665295 665333 665278 665308 665300 665337 665317 665324 665340 665319 665332 665341 665183 665242 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1121 - H90--2D54a2y5G: aSvuabgcehSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg II IV VI VIII DuPont-11418 ENDOCRINE SYSTEM PARATHYROID GLANDS ' NO ABNORMALITY DETECTED (8) 665174 665178 665211 665225 665230 665271 665278 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (9) 665183 665200 665234 665242 665261 665291 665310 665326 665333 Company Sanitized. Does not contain T S C A CBI - 1122- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 ENDOCRINE SYSTEM ADRENAL GLANDS (10) NO ABNORMALITY DETECTED 1 1 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -1123- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED AGGREGATES, LYMPHOID, CHOROID PLEXUS. (10) 665174 665178 665211 665221 665230 665271 665278 665317 665319 665225 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 1 Com pany Sanitized. Does not contain T S C A CBI - 1124- H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (9) 665174 665178 665211 665221 665225 665230 665271 665278 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI - 1125- > H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI - 1126- ) ) ' H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Ra.ts Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 .10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -1127- ) H90--2D5a42y5G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI -1128- > 9H0--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations Microscopic Observations in Female Rats Listing Individual Animais Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T SC A CBI -1129- ))) H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations_____________ ______________________________________ DuPont-11418 Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM OVARIES NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Com pany Sanitized. Does not contain T SC A CBI - 1130- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_______ __________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS . TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Company Sanitized. Does not contain T S C A CBI -1131- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 REPRODUCTIVE SYSTEM VAGINA ESTRUS STAGE: METESTRUS. ESTRUS STAGE: ESTRUS. ESTRUS STAGE: PROESTRUS. (10) 665174 665221 665271 665319 665178 665225 665211 665230 665278 665317 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665310 665234 665242 665326 665200 665261 665291 665333 665337 Com pany Sanitized. Does not contain T S C A CBI -1132- H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg II IV VI VIII REPRODUCTIVE SYSTEM MAMMARY GLAND (FEMALE) NO ABNORMALITY DETECTED (10) 665174 665178 665211 665221 665225 665230 665271 665278 665317 665319 (10) 665183 665200 665234 665242 665261 665291 665310 665326 665333 665337 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T SC A CBI -1133- H90--2D5a4y25G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED DERMATITIS, FOCAL'. (10) 665174 665178 665211 665225 665230 665271 665278 665317 665319 665221 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665242 665261 665310 665326 665333 665337 665291 Company Sanitized. Does not contain T SC A CBI - 1134- H90--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-GenerationReproductionEvaluations___________________________________________ ________ DuPont-11418 Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Main Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg II IV VI VIII SPECIAL SENSES SYSTEM EYE(S ) WITH OPTIC NERVE NO ABNORMALITY DETECTED OPTIC NERVE NOT PRESENT, UNILATERAL. OPTIC NERVE NOT PRESENT, BILATERAL. INFLAMMATION, PERIOCULAR, UNILATERAL. (10) 665174 665178 665221 665225 665271 665278 665317 665319 665178 665221 665225 665230 665271 665174 665211 665230 FOLD/ROSETTE, RETINAL. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665183 665200 665234 665261 665310 665183 665242 665261 665326 665337 665242 665291 665326 665333 665291 Company Sanitized. Does not contain T SC A CBI - 1135- ) H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 DIGESTIVE SYSTEM LIVER NECROSIS, FOCAL. INFLAMMATION, SUBACUTE/CHRONIC. FATTY CHANGE, PERIPORTAL. FATTY CHANGE, MEDIAN CLEFT. (10) 665008 665042 665043 665064 665081 665098 665106 665121 665149 665159 665043 665064 665081 665106 665121 665043 665106 665149 i Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified 1 (10) 665062 665146 665002 665007 665031 665062 665067 665095 665112 665138 665146 665158 665002 665031 665002 665031 665112 665146 665158 Com pany Sanitized. Does not contain T S C A CBI - 1136- H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproduction Evaluations____________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DIGESTIVE SYSTEM PANCREAS FOCUS OF CELLULAR ALTERATION, BASOPHILIC. (1) 665042 t Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T SC A CBI -1137- H90--2P5a4y25G:aSvuabgechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected . Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM ESOPHAGUS NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T SC A CBI - 1138- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM STOMACH NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A O 00 H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM DUODENUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI - 1140- H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 DIGESTIVE SYSTEM JEJUNUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI -1141- ) 9H0--2D5a4y25G:aSvuagbechSrtoundiyciTnoRxaictistywith One-Generation ReproductionEvaluations___________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg /kg I III V VII DIGESTIVE SYSTEM ILEUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1142- )) ) H90--2D5a42y5G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations___________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM CECUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI - 1143- 9H0--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywithOne-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice DuPont-11418 LESIONS TREATMENT LESION INCIDENCE (Animal #)[ Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM COLON NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1144- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 DIGESTIVE SYSTEM RECTUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI -1145- H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations___________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DIGESTIVE SYSTEM SALIVARY GLANDS NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI -1146- H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations___________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII URINARY SYSTEM KIDNEYS NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI -1147- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 URINARY SYSTEM URINARY BLADDER NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1148- ) H90--2D5a4y25G:aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations____________________________________________________ DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII RESPIRATORY SYSTEM LUNGS MACROPHAGES, ALVEOLAR, FOCAL. HEMORRHAGE, ALVEOLAR. (1) 665042 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI -1149- )) H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 RESPIRATORY SYSTEM TRACHEA NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI -1150- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DuPont-11418 RESPIRATORY SYSTEM PHARYNX/LARYNX NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1151 - H90--2D54a2y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 RESPIRATORY SYSTEM NOSE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A C 8 I - 1152- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 CARDIOVASCULAR SYSTEM HEART NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI -1153- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII DuPont-11418 CARDIOVASCULAR SYSTEM AORTA NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1154- )) ) H90--2D5a4y25G: aSvuabgechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM SPLEEN NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI - 1155- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM THYMUS HEMORRHAGE. (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI - 1156- H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MANDIBULAR LYMPH NODE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI - 1157- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 LYMPHATIC AND HEMATOPOIETIC SYSTEM MESENTERIC LYMPH NODE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1158- ') ) ) H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS t TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII LYMPHATIC AND HEMATOPOIETIC SYSTEM BONE MARROW NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI -1159- H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxaictistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg /kg mg/kg I III V VII ) DuPont-11418 ENDOCRINE SYSTEM PITUITARY GLAND NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1160- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg /kg mg/kg mg/kg I III V VII DuPont-11418 ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. (10) 665008 665042 665064 665081 665098 665106 665121 665149 665159 665043 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665031 665095 665112 665138 665002 665007 665062 665067 665146 665158 Company Sanitized. Does not contain T SC A CBI -1161 - H90--2D5a4y25G:aSvuabgechSrtoundiyciTnoRxiactistywith One-GenerationReproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS 4 TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 ENDOCRINE SYSTEM ADRENAL GLANDS NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI - 1162- )' ) > H90--2D5a4y25G:aSvuagbechSrtoundiyc iTnoRxiactistywith One-GenerationReproduction Evaluations____________________________________________________DuPont-11418 Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII NERVOUS SYSTEM BRAIN NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI - 1163- )> H90--2D54a2y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg I III V VII > DuPont-11418 NERVOUS SYSTEM SPINAL CORD NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A C 8I -1164- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 NERVOUS SYSTEM SCIATIC NERVE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI - 1165- ) H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations_______________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII ) DuPont-11418 MUSCULAR AND SKELETAL SYSTEM SKELETAL MUSCLE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1166- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ _ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 MUSCULAR AND SKELETAL SYSTEM FEMUR/KNEE JOINT (1) NO ABNORMALITY DETECTED 1 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1167- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I Ill V VII DuPont-11418 MUSCULAR AND SKELETAL SYSTEM STERNUM NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain TSC A CBI -1168- H90--2D5a42y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation ReproductionEvaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM TESTES NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T S C A CBI - 1169- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________ ________________ Microscopic Observations in Male Rats Listing Individual Animals Affected ' Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM EPIDIDYMIDES NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI -1170- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM PROSTATE NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T SC A C 8 I -1171- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________ Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg /kg I III V VII DuPont-11418 REPRODUCTIVE SYSTEM SEMINAL VESICLES NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1172- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 CUTANEOUS SYSTEM SKIN NO ABNORMALITY DETECTED (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Com pany Sanitized. Does not contain T S C A CBI -1173- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Microscopic Observations in Male Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Males 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg I III V VII DuPont-11418 SPECIAL SENSES SYSTEM EYE(S ) WITH OPTIC NERVE OPTIC NERVE NOT PRESENT, UNILATERAL. (1) 665042 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified Company Sanitized. Does not contain T SC A CBI - 1174- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations aj vb xi o u oo rt Pj,' c r u saixr c T 3 s t -e3 T i vr^ u u u j1. mTiinx i mu ua lxea? .rTi\.if_ jf_ a^ n>w tv- Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 ENDOCRINE SYSTEM THYROID GLAND NO ABNORMALITY DETECTED HYPERTROPHY, FOLLICULAR CELL. ECTOPIC THYMUS TISSUE. (10) 665189 665197 665201 665204 665228 665256 665260 665276 665323 665327 Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (10) 665209 665237 665275 665282 665299 665328 665335 665288 665303 665229 Company Sanitized. Does not contain T SC A CBI -1175- H90--2D5a4y25G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-GenerationReproductionEvaluations tiu'utAu l U i s C u y -i c v/J-yDi_ ^ S jl \7 aj_cJi u__ u s xJ u m c t u t t_a 1x t_: rr-vi _c tjc - S, ru xJ s_ ct_x^i t y m u iv iQ u a i Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice i n x i u a x na 7VlfI c L - t c u LESIONS TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg /kg mg/kg mg/kg mg/kg II IV VI VIII ) DuPont-11418 REPRODUCTIVE SYSTEM UTERUS NO ABNORMALITY DETECTED Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) 665335 1 Company Sanitized. Does not contain T SC A CBI - 1176- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations__________________________________________________ Microscopic Observations in Female Rats Listing Individual Animals Affected Neoplastic and Non-Neoplastic Lesions Recovery Sacrifice LESIONS 4 TREATMENT LESION INCIDENCE (Animal #) Females 0 10 100 1000 mg/kg mg/kg mg/kg mg/kg II IV VI VIII DuPont-11418 REPRODUCTIVE SYSTEM VAGINA ESTRUS STAGE : PROESTRUS. Figure in parentheses is number of animals microscopically examined for this tissue The absence of a number indicates the lesion specified was not identified (1) 665335 Company Sanitized. Does not contain T SC A CBI - 1177- H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX P INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P, MALE RATS - 1178 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN Pi MALE RATS EXPLANATORY NOTES Notes Test Days 1-74 = Premating period Test Days 74-88 = Cohabitation period Abbreviations NR = Not recovered; the given sign was observed on the date that the animal died. -1179- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 COLORED DISCHARGE RIGHT E YE(S ) RED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 ALOPECIA RIGHT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 84 84 112 112 NR 105 113 NR - 1180- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 664996 664994 665046 665021 665087 665079 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 77 113 NR -1181 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: III-O DOSE: 10 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 77 113NR 77 113NR -1182- Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: III-O DOSE: 10 M G / K G / D A Y ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665113 665056 665025 665038 665006 665167 665020 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 ALOPECIA BOTH FRONT L E G (S ) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 113 113 NR 112 - 1183- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 - 1184- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665055 665066 665039 665003 665088 665147 ALOPECIA LEFT FRONT L E G (S ) SACRIFICED BY DESIGN TEST DAY 113 SORE LEFT FRONT TOE(S) SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 91 113 NR 105 105 - 1185 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 NO ABNORMALITIES DETECTED FOUND DEAD TEST DAY 89 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S ) SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 111 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 112 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 77 111 NR 84 111 NR - 1186 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations ___________________ DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665063 665090 665057 665011 665109 664998 665077 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 ALOPECIA RIGHT REAR L EG(S ) SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 113 - 1187 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Pay Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX Q INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN Pi FEMALE RATS DURING GESTATION -1188- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Notes This appendix contains data from females with evidence of copulation (gestation days 0-21), and from females that did not show evidence of mating (days signs were observed were determined from the initiation of test substance administration (days are greater than 21). Abbreviation CS = Continuing sign; the given sign was observed on the last day of the report period. -1189- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE CAGEBOARD PLUGS SPERM NEGATIVE VAGINAL PLUG SPERM POSITIVE VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG ALOPECIA ABDOMEN VAGINAL PLUG ALOPECIA BOTH FRONT LEG(S) VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA RIGHT REAR LEG(S ) ALOPECIA ABDOMEN VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG COLORED DISCHARGE RIGHT E Y E (S ) RED VAGINAL PLUG VAGINAL PLG 00 00 00 88 88 88 88 00 00 00 00 00 00 14 21 CS 00 0 21 00 00 00 14 21 CS 18 21 CS 00 00 00 00 77 00 0 o - 1190 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED oo oo 665240 665203 CAGEBOARD PLUGS SPERM POSITIVE CAGEBOARD PLUGS SPERM POSITIVE 0 0 0 0 - 1191 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 VAGINAL PLUG ALOPECIA BOTH FRONT PAW(S) CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LE G (S ) CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S ) CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA ABDOMEN CAGEBOARD PLUGS SPERM POSITIVE NO ABNORMALITIES DETECTED ALOPECIA BOTH FRONT L EG(S ) CAGEBOARD PLUGS SPERM POSITIVE NO ABNORMALITIES DETECTED CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L E G (S ) ALOPECIA LEFT FRONT LE G (S ) ALOPECIA LEFT REAR L E G (S ) ALOPECIA ABDOMEN VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA ABDOMEN CAGEBOARD PLUGS SPERM POSITIVE 00 18 21 00 00 0 21 CS 0 21 CS 00 00 0 21 CS 0 21 CS 00 00 21 21 CS 00 00 0 21 CS 00 00 00 00 0 21 0 21 0 21 0 21 0 21 00 00 00 0 21 00 00 -1192- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665253 665286 665281 665186 665330 665294 665244 665258 VAGINAL PLUG ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE 00 0 21 0 21 00 00 00 00 00 00 00 00 00 - 1193- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L E G (S) VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA BOTH FRONT PAW(S) CAGEBOARD PLUGS SPERM POSITIVE CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG VAGINAL PLUG 00 00 00 00 00 00 00 00 00 00 00 00 0 18 0 14 00 00 00 07 00 00 00 00 00 00 - 1194 - Company Sanitized. Does not contain TSCA CBI r\ H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665195 665314 665316 665173 CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG ALOPECIA ABDOMEN VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE 00 00 00 14 21 00 00 00 - 1195- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 CAGEBOARD PLUGS SPERM NEGATIVE VAGINAL PLUG ALOPECIA RIGHT FRONT LEG(S ) NO ABNORMALITIES DETECTED VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG VAGINAL PLUG ALOPECIA BOTH FRONT PAW(S) VAGINAL PLUG VAGINAL PLUG CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S ) CAGEBOARD PLUGS SPERM POSITIVE VAGINAL PLUG SPERM POSITIVE VAGINAL PLUG VAGINAL PLUG ALOPECIA BOTH FRONT LEG(S) ALOPECIA BOTH FRONT PAW(S) CAGEBOARD PLUGS SPERM POSITIVE ALOPECIA RIGHT FR6NT LEG(S) VAGINAL PLUG 78 78 78 78 00 21 21 CS 00 00 00 00 00 0 21 00 00 00 00 7 21 CS 7 21 CS 00 00 00 00 00 00 0 21 14 21 00 00 7 21 CS 00 - 1196- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665213 665280 CAGEBOARD PLUGS SPERM POSITIVE CAGEBOARD PLUGS SPERM NEGATIVE 00 00 78 78 78 78 - 1197 - Com pany Sanitized. Does not contain T SC A CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX R INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN Pj FEMALE RATS DURING LACTATION - 1198 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Notes This appendix contains data from females that delivered a litter (lactation days 0-21), and from females that did not deliver a litter (days signs were observed were determined from the initiation of test substance administration (days are greater than 21). Test days for all animal fates are determined from the initiation of test substance administration. Abbreviations NR = Not recovered; the given sign was observed on the date that the animal died. -1199- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665220 665334 665257 665175 665336 665192 665232 665307 665246 665264 665185 665206 665306 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 132 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 131 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT L EG(S ) SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA RIGHT REAR LEG(S) ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 0 21 NR 0 21 NR 0 21 NR 0 21 NR - 1200 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: II-O DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665226 665198 665249 665284 665240 665203 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 127 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 - 1201 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S) SACRIFICED BY DESIGN TEST DAY 123 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S) ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S) FOUND DEAD TEST DAY 112 ALOPECIA LEFT FRONT L EG(S) ALOPECIA LEFT REAR L EG{S ) ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA ABDOMEN SACRIFICED BY DESIGN TEST DAY 124 0 21 NR 21 21 NR 0 21 NR 0 21 NR 07 07 0 21 NR 0 21 NR 07 07 0 21 NR 0 21 NR 0 21 NR 0 21 NR - 1202 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY LAST DAY OBSERVED OBSERVED 665290 665253 665286 665281 665186 665330 665294 665244 665258 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 124 0 21 NR 0 21 NR 7 21 NR - 1203 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665207 665273 665274 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 123 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA LEFT FRONT L E G (S ) SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 /< * * * \, - 1204 - Company Sanitized. Does not contain TSCA C8I H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: V I -0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665272 665195 665314 665316 665173 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA UNDERBODY ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT L EG(S ) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 129 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 0 21 NR 7 21 NR 7 21 NR - 1205 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY .ANIMAL NUMBER OBSERVATION 665296 665193 665320 665315 665318 665279 665254 665245 665322 665321 665171 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 ALOPECIA RIGHT FRONT LEG(S) SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 ALOPECIA RIGHT HIND QUARTERS SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 ALOPECIA BOTH FRONT PAW(.S) SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT PAW(S) ALOPECIA BOTH FRONT LEG(S) MASS 1 0.5 cm LEFT SHOULDER(S) MASS 1 2.0 cm LEFT SHOULDER(S) SORE LEFT SHOULDER(S) SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 FIRST DAY OBSERVED LAST DAY OBSERVED 0 14 7 21 NR 0 21 NR 0 21 NR 0 21 NR 14 14 21 21 NR 21 21 NR - 1206 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL CLINICAL OBSERVATIONS IN P FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY ANIMAL NUMBER OBSERVATION FIRST DAY OBSERVED LAST DAY OBSERVED 665265 665169 665191 665231 665255 665213 665280 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 122 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 120 ALOPECIA BOTH FRONT L EG(S ) ALOPECIA BOTH FRONT PAW(S) SACRIFICED BY DESIGN TEST DAY 124 ALOPECIA RIGHT FRONT L EG(S ) SACRIFICED BY DESIGN TEST DAY 121 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 118 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 119 NO ABNORMALITIES DETECTED SACRIFICED BY DESIGN TEST DAY 121 0 21 NR 0 21 NR 0 21 NR - 1207 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX S INDIVIDUAL BODY WEIGHTS OF P! MALE RATS - 1208 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHTS OF Pi MALE RATS EXPLANATORY NOTES Notes Test Days 74-88 = Cohabitation period Abbreviations FD = Found Dead SD = Sacrificed by design DuPont-11418 - 1209 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BO D Y WEIGHTS (g) OF P MAL E RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665144 665104 665044 665141 . 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 70 571.4 545.7 519.5 481.9 559.4 626.3 499.7 623.8 474.7 554.6 494.5 533.4 595.9 524.9 482.7 504.0 534.2 503.4 494.3 621.3 77 578.6 555.7 501.2 489.9 554.2 637.0 493.5 640.7 460.9 557.9 503.4 540.0 600.5 522.5 488.2 515.7 552.8 505.6 484.0 618.6 84 596.0 566.8 525.5 494.4 568.5 640.4 499.7 655.5 483.7 565.5 501.5 547.9 616.0 530.1 496.5 530.7 567.5 510.1 502.2 635.1 91 610.4 580.8 524.6 510.2 577.6 652.4 502.9 668.4 490.1 583.0 504.7 551.4 630.2 522.6 502.5 538.9 575.5 515.9 516.1 652.4 98 601.5 600.5 531.4 518.5 595.7 647.5 515.6 692.0 503.6 593.2 513.8 560.0 630.9 527.3 502.8 547.5 573.5 526.9 529.4 659.4 105 597.4 615.7 533.5 524.2 620.7 658.8 524.6 701.7 508.0 596.9 522.6 563.1 648.0 533.3 509.8 559.9 588.7 530.0 537.9 665.9 SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) - 1210- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHTS (g) OF P MALE RATS GROUP: III-O DOSE: 10 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 70 525.8 554.0 515.8 547.6 520.0 491.5 495.1 521.3 478.8 547.4 512.5 464.4 577.9 594.0 474.9 505.3 549.3 558.7 480.6 541.3 77 511.4 558.1 507.8 530.9 510.7 489.9 486.6 507.7 470.0 554.5 494.6 455.4 565.2 573.6 470.5 471.0 541.5 532.9 489.8 539.9 84 541.2 571.5 529.9 540.9 515.9 503.1 503.8 530.8 480.0 566.5 518.1 470.1 588.0 602.3 491.4 511.8 569.8 576.4 501.0 559.7 91 558.8 583.5 535.0 550.8 519.6 517.8 509.2 532.1 495.5 568.6 531.8 468.2 605.9 622.3 496.3 517.1 583.3 582.3 506.7 581.5 98 560.2 591.9 546.2 557.3 535.3 532.1 521.9 547.0 506.8 578.1 546.3 481.5 627.1 627.6 511.1 531.1 587.7 605.9 522.0 589.2 105 564.6 602.8 553.8 570.7 540.0 536.2 519.2 551.4 519.1 585.8 551.7 487.9 635.2 643.3 523.5 533.1 599.6 608.6 534.4 602.9 SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) - 1211 - Company Sanitized. Does not contain TSCA CBI /'" 'N H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BOD Y WEI G H T S (g) OF P M A L E RATS GROUP: V-0 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 70 479.3 556.2 479.5 485.1 418.2 547.8 452.1 593.8 456.0 550.8 530.7 509.6 535.5 505.5 503.0 491.5 521.9 564.7 452.4 513.6 77 461.9 562.6 485.5 482.4 456.4 560.5 446.8 533.7 450.3 548.4 503.9 503.2 530.6 521.9 497.8 480.5 476.5 571.9 448.2 497.6 84 481.8 567.1 501.3 490.2 476.3 578.4 466.2 571.2 465.2 563.4 530.4 515.1 547.7 530.2 504.4 502.0 523.5 583.8 452.3 505.1 91 496.9 575.0 506.2 496.3 485.1 589.3 469.0 602.1 466.0 557.6 541.4 525.5 564.8 527.3 521.9 518.6 541.9 577.5 459.8 523.0 98 504.5 584.5 509.7 507.5 496.3 612.3 492.3 627.1 478.2 575.4 555.2 541.1 573.4 544.2 539.3 531.0 556.6 596.4 470.3 533.4 105 511.0 591.7 526.7 511.6 508.4 613.8 497.6 633.7 490.8 572.6 557.9 548.5 588.8 555.1 556.4 535.4 566.6 594.5 480.1 548.6 SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) - 1212- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BOD Y WEIGHTS (g) OF P M A L E RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 70 578.3 487.8 425.4 486.0 499.5 515.0 540.4 506.4 445.9 499.5 566.2 558.7 589.8 553.2 499.7 574.6 588.7 568.5 476.4 525.4 77 573.7 488.2 426.9 491.3 500.8 518.6 548.2 514.4 449.6 492.8 564.7 571.0 598.6 556.2 496.0 572.5 567.4 565.3 474.4 513.4 84 91 98 576.9 486.2 433.1 505.9 511.2 536.1 556.2 526.9 452.1 501.0 577.0 583.3 604.4 568.1 505.8 584.8 594.2 579.1 483.2 529.5 FD (DAY 495.6 445.8 515.7 519.3 545.2 561.7 528.4 463.2 503.7 588.6 596.5 612.4 568.2 523.1 595.3 608.2 592.1 484.9 535.7 507.4 444.0 531.8 507.7 548.4 573.3 549.8 465.9 514.2 606.8 606.9 623.0 575.2 538.8 597.2 628.0 603.1 497.8 552.2 105 518.1 452.3 535.0 504.0 553.5 584.2 541.0 475.2 522.3 613.2 611.4 604.3 572.3 537.9 612.8 639.8 604.7 506.5 550.3 SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 111) SD (DAY 112) SD (DAY 112) SD (DAY 112) SD. (DAY 112) SD (DAY 112) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) SD (DAY 113) - 1213 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX T INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS - 1214- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL BODY WEIGHT GAINS OF Pi MALE RATS EXPLANATORY NOTES DuPont-11418 Notes Test Days 74-88 = Cohabitation period - 1215 - Company Sanitized. Does not contain TSCA CBI /""S H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY W E I G H T GAINS (g) OF P MAL E RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 665029 665000 665166 665012 664996 664994 665046 665021 665087 665079 70-77 77-84 84-91 91-98 98-105 70-105 7.2 10.0 -18.3 8.0 -5.2 10.7 -6.2 16.9 -13.8 3.3 8.9 6.6 4.6 -2.4 5.5 11.7 18.6 2.2 -10.3 -2.7 17.4 11.1 24.3 4.5 14.3 3.4 6.2 14.8 22.8 7.6 -1.9 7.9 15.5 7.6 8.3 15.0 14.7 4.5 18.2 16.5 14.4 14.0 -0.9 15.8 9.1 12.0 3.2 12.9 6.4 17.5 3.2 3.5 14.2 -7.5 6.0 8.2 8.0 5.8 13.9 17.3 -8.9 19.7 6.8 8.3 18.1 -4.9 12.7 23.6 13.5 10.2 9.1 8.6 0.7 4.7 0.3 8.6 -2.0 11.0 13.3 7.0 -4.1 15.2 2.1 5.7 25.0 . 11.3 9.0 9.7 4.4 3.7 8.8 3.1 17.1 6.0 7.0 12.4 15.2 3.1 8.5 6.5 26.0 70.0 14.0 42.3 61.3 32.5 24.9 77.9 33.3 42.3 28.1 29.7 52.1 8.4 27.1 55.9 54.5 26.6 43.6 44.6 - 1216- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEI G H T GAINS (g) OF P MAL E RATS GROUP: III-O DOSE: 10 M G / K G / D A Y DAYS ON TEST: ANIMAL NUMBER 665153 665037 665163 665001 665126 665125 665017 665071 665032 664997 665110 665041 665058 665113 665056 665025 665038 665006 665167 665020 70-77 77-84 84-91 91-98 98-105 70-105 -14.4 4.1 -8.0 -16.7 -9.3 -1.6 -8.5 -13.6 -8.8 7.1 -17.9 -9.0 -12.7 -20.4 -4.4 -34.3 -7.8 -25.8 9.2 -1.4 29.8 13.4 22.1 10.0 5.2 13.2 17.2 23.1 10.0 12.0 23.5 14.7 22.8 28.7 20.9 40.8 28.3 43.5 11.2 19.8 17..6 12..0 5.,1 9..9 3..7 14..7 5..4 1 ..3 15..5 2..1 13,.7 -1..9 17 .9 20..0 4..9 5..3 13..5 5,.9 5..7 21..8 1 ..4 8.,4 11..2 6.,5 15..7 14..3 12..7 14..9 11..3 9..5 14..5 13..3 21.: 2 5..3 14,.8 14,.0 4..4 23..6 15..3 7,.7 4..4 10..9 7..6 13 .4 4..7 4,.1 -2 ,.7 4..4 12..3 7..7 5..4 6..4 8 .1 15 .7 12 .4 2 .0 11..9 2 .7 12 .4 13 .7 38..8 48..8 38.,0 23.,1 20.,0 44..7 24..1 30..1 40..3 38..4 39,.2 23..5 57,.3 49..3 48..6 27,.8 50..3 49 .9 53 .8 61 .6 - 1217- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIV I D U A L BODY W E I G H T GAINS (g) OF P MAL E RATS GROUP: V-0 DOSE: 100 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 665140 665114 665139 665111 665055 665066 665039 665003 665088 665147 70-77 77-84 84-91 91-98 98-105 70-105 -17.4 6.4 6.0 -2.7 38.2 12.7 -5.3 -60.1 -5.7 -2.4 -26.8 -6.4 -4.9 16.4 -5.2 -11.0 -45.4 7.2 -4.2 -16.0 19.9 4.5 15.8 7.8 19.9 17.9 19.4 37.5 14.9 15.0 26.5 11.9 17.1 8.3 6.6 21.5 47.0 11.9 4.1 7.5 15..1 7..9 4..9 6,.1 8..8 10..9 2..8 30..9 0..8 -5..8 11..0 10..4 17,.1 -2..9 17,.5 16,.6 18 .4 -6,.3 7 .5 17 .9 7. 6 9. 5 3.,5 11..2 11..2 23..0 23. 3 25. 0 12. 2 17..8 13. 8 15..6 8.,6 16.,9 17.,4 12.,4 14..7 18..9 10.,5 10..4 6..5 7..2 17..0 4..1 12..1 1..5 5..3 6..6 12..6 -2..8 2..7 7 .4 15,.4 10..9 17..1 4 .4 10 .0 -1,.9 9 .8 15 .2 31..7 35..5 47..2 26..5 90..2 66..0 45..5 39..9 34..8 21..8 27,.2 38..9 53,.3 49,.6 53,.4 43 .9 44 .7 29,.8 27..7 35 .0 - 1218- Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 I NDIVIDUAL BOD Y W E I G H T GAINS (g) OF P M A L E RATS GROUP: VII-0 DOSE: 1000 MG/KG/DAY DAYS ON TEST: ANIMAL NUMBER 665050 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 665018 665065 665063 665090 665057 665011 665109 664998 665077 70-77 77-84 84-91 91-98 98-105 70-105 -4.6 0.4 1.5 5.3 1.3 3.6 7.8 8.0 3.7 -6.7 -1.5 12.3 8.8 3.0 -3.7 -2.1 -21.3 -3.2 -2.0 -12.0 3.2 -2.0 6.2 14.6 10.4 17.5 8.0 12.5 2.5 8.2 12.3 12.3 5.8 11.9 9.8 12.3 26.8 13.8 8.8 16.1 9.4 12.7 9.8 8.1 9.1 5.5 1.5 11.1 2.7 11.6 13.2 8.0 0.1 17.3 10.5 14.0 13.0 1.7 6.2 11.8 -1.8 16.1 -11.6 3.2 11.6 21.4 2.7 10.5 18.2 10.4 10.6 7.0 15.7 1.9 19.8 11.0 12.9 16.5 10.7 8.3 3.2 -3.7 5.1 10.9 -8.8 9.3 8.1 6.4 4.5 -18.7 -2.9 -0.9 15.6 11.8 1.6 8.7 -1.9 30.3 26.9 49.0 4.5 38.5 43.8 34.6 29.3 22.8 47.0 52.7 14.5 19.1 38.2 38.2 51.1 36.2 30.1 24.9 - 1219- Company Sanitized. Does not contain TSCA CBI H90--2D54a2y5G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-11418 APPENDIX U INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION - 1220 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP = No litter delivered; data excluded from statistical analysis. = No Data - 1221 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BOD Y WEI G H T S (g) OF P F E M A L E RATS DURI N G GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS : ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0 7 14 21 274.2 317.1 - 271.1 300.4 320.0 296.9 335.8 302.2 310.5 308.1 332.8 295.6 265.8 292.0 282.3 333.4 283.1 284.5 254.3 299.1 346.5 296.8 315.6 345.3 306.1 375.0 337.2 346.1 343.3 375.1 326.5 304.7 325.2 317.3 357.8 314.3 313.1 276.2 340.5 390.5 330.0 346.1 382.6 378.1 407.9 381.1 371.2 371.2 402.2 355.5 359.8 350.8 336.3 379.1 343.8 343.1 308.2 435.8 473.5 413.4 427.3 477.9 464.9 516.3 464.5 392.8 434.3 496.1 447.9 419.0 455.0 439.4 466.6 426.2 420.1 376.2 ANIMAL STATUS a NP aEvidence ofcopulation was not observed, but animal delivered alitter. - 1222 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIG H T S (g) OF P FEMALE RATS DURING GEST A T I O N GROUP: IV-0 DOSE: 10 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 0 7 14 21 284.6 282.5 370.5 292.8 328.5 - 278.8 - 332.6 272.7 322.2 348.4 341.2 294.5 237.2 254.1 300.3 281.3 259.7 287.1 309.8 327.0 391.5 321.7 343.9 305.8 - 354.5 314.5 325.8 377.7 378.5 346.7 279.1 284.6 345.3 309.6 281.7 317.9 344.0 365.0 416.7 348.2 396.8 - 326.4 _ 389.9 362.6 388.7 418.6 414.8 381.3 323.5 335.4 389.5 358.7 305.2 359.8 412.7 451.3 460.4 429.8 466.5 _ 401.6 - 500.0 456.1 466.1 488.6 476.1 463.3 394.8 403.8 457.8 464.2 364.8 438.6 ANIMAL STATUS a __________ ;______________________ aEvidence ofcopulation was not observed, but animal delivered a litter. - 1223 - Company Sanitized. Does not contain TSCA CBI Risati!ini^ H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction valuations DuPont-11418 INDIVIDUAL B O D Y WEIGHTS (g) OF P FEMALE RATS DURI N G G E S T A T I O N GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 7 14 21 229 .3 269 .2 310,.0 256,.6 326 .6 306,.3 327,.6 333..2 345..3 324,.2 283..1 324..5 310.,9 291..6 276..0 294..5 292.,4 318. 4 290. 5 310..5 257 .0 299 .0 349 .4 288 .9 350 .4 334..2 366 .7 354..4 389..4 351..5 318..6 323..4 347,.8 314..6 290..7 323..3 335,,1 365. 7 314. 0 342..4 288 .6 317 .0 391 .4 325 .5 373 .8 364 .9 394 .5 403,.8 429..2 383..9 348..4 334..1 387..4 348.,9 329..6 374..2 372 ,.9 417..5 338..8 378..0 387 .7 357 .9 451 .1 405 .4 457 .3 434,.6 475..7 411..0 503..6 455..8 430..8 341..9 448..4 414.,1 415..7 436..3 430..0 512.,0 427. 9 478..8 ANIMAL STATUS - 1224 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __________________ DuPont-11418 INDIVIDUAL BOD Y WEIGHTS (g) OF P FEMALE RATS D U R I N G G ESTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 0 7 14 21 _ 328.7 - 262.9 321.2 348.2 349.1 316.2 290.0 271.0 301.3 252.8 296.6 358.6 275.6 298.9 275.3 320.8 301.4 - - 364.0 - 296.7 359.7 372.0 371.1 345.4 311.1 301.1 328.5 281.4 332.9 388.1 298.0 321.7 298.4 350.2 333.2 - - 402.9 - 328.3 400.7 420.9 376.7 384.8 341.2 325.5 356.0 306.9 367.3 423.5 326.6 363.6 331.5 388.3 376.2 - .487.6 406.1 503.9 524.5 381.5 479.6 421.3 394.4 438.2 385.2 429.4 517.8 414.3 405.0 413.8 500.0 451.5 - ANIMAL STATUS a a NP a aEvidence of copulation was not observed, but animal delivered alitter. - 1225 - Company Sanitized. Does not contain TSCA CBI H90--2D54a2y5G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-11418 APPENDIX V INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION - 1226 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP = No litter delivered; data excluded from statistical analysis. = No Data - 1227 - Company Sanitized. Does not contain TSCA CBI / 8***V', H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEIG H T GAINS (g) OF P FEMALE RATS DUR I N G GEST A T I O N GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0-7 7-14 14-21 0-21 24.9 29.4 - 25.7 15.2 25.3 9.2 39.2 35.0 35.6 35.2 42.3 30.9 38.9 33.2 35.0 24.4 31.2 28.6 21.9 41.4 44.0 33.2 30.5 37.3 72.0 32.9 43.9 25.1 27.9 27.1 29.0 55.1 25.6 19.0 21.3 29.5 30.0 32.0 95.3 83.0 83.4 81.2 95.3 86.8 108.4 83.4 21.6 63.1 93.9 92.4 59.2 104.2 103.1 87.5 82.4 77.0 68.0 161.6 156.4 142.3 126.9 157.9 168.0 180.5 162.3 82.3 126.2 163.3 152.3 153.2 163.0 157.1 133.2 143.1 135.6 121.9 ANIMAL STATUS a NP aEvidence ofcopulation was not observed, but animal delivered a litter. - 1228 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEI G H T GAINS (g) OF P FEMALE R A T S D U R I N G G ESTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 0-7 7-14 14-21 0-21 25.2 44.5 21.0 28.9 15.4 - 27.0 - 21.9 41.8 3.6 29.3 37.3 52.2 41.9 30.5 45.0 28.3 22.0 30.8 34.2 38.0 25.2 26.5 52.9 20.6 - 35.4 48.1 62.9 40.9 36.3 34.6 44.4 50.8 44.2 49.1 23.5 41.9 68.7 86.3 43.7 81.6 69.7 75.2 - 110.1 93.5 77.4 70.0 61.3 82.0 71.3 68.4 68.3 105.5 59.6 78.8 128.1 168.8 89.9 137.0 138.0 122.8 167.4 183.4 143.9 140.2 134.9 168.8 157.6 149.7 157.5 182.9 105.1 151.5 ANIMAL STATUS a a aEvidence of copulation was not observed, but animal delivered a litter. - 1229 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY W E I G H T GAI N S (g) OF P FEMALE RATS D U R I N G G ESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 0-7 7-14 14-21 0-21 27..7 29..8 39..4 32..3 23..8 27..9 39..1 21..2 44..1 27,,3 35.,5 .1- 1 . 36..9 23..0 14..7 28,.8 42..7 47..3 23..5 31..9 31..6 18..0 42..0 36..6 23 .4 30..7 27..8 49..4 39..8 32..4 29..8 10..7 39..6 34..3 38..9 50..9 37..8 51..8 24..8 35..6 99.1 40.9 59.7 79.9 83.5 69.7 81.2 7.2 74.4 71.9 82.4 7.8 61.0 65.2 86.1 62.1 57.1 94.5 89.1 100.8 158.4 88.7 141.1 148.8 130.7 128.3 148.1 77.8 158.3 131.6 147.7 17.4 137.5 122.5 139.7 141.8 137.6 193.6 137.4 168.3 ANIMAL - 1230 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BO D Y W E I G H T G A I N S (g) OF P FEMALE RAT S D U R I N G GESTA T I O N GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 0-7 7-14 14-21 0-2 - 35.3 - 33.8 38.5 23.8 22.0 29.2 21.1 30.1 27.2 28.6 36.3 29.5 22.4 22.8 23.1 29.4 31.8 - - 38.9 - 31.6 41.0 48.9 5.6 39.4 30.1 24.4 27.5 25.5 34.4 35.4 28.6 41.9 33.1 38.1 43.0 - - 84.7 - 77.8 103.2 103.6 4.8 94.8 80.1 68.9 82.2 78.3 62.1 94.3 87.7 41.4 82.3 111.7 75.3 - - 158.9 - 143.2 182.7 176.3 32.4 163.4 131.3 123.4 136.9 132.4 132.8 159.2 138.7 106.1 138.5 179.2 150.1 - ANIMAL STATUS a a NP a aEvidence ofcopulation was not observed, but animal delivered a litter. - 1231 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX W INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION - 1232 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 ^ INDIVIDUAL BODY WEIGHTS OF Pi FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note Test days for animal fates are determined from the initiation of test substance administration. Abbreviations FD = Found Dead NP = Not pregnant = No Data - 1233 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BOD Y WEIG H T S (g) OF P FEMALE RATS DURI N G L A C T A T I O N GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0 7 14 21 313.0 367.3 372.3 306.0 321.9 349.6 346.6 388.5 351.2 - 343.7 379.3 332.3 317.7 337.4 334.6 349.9 311.4 303.9 286.4 332.1 373.5 382.7 308.4 338.7 354.1 353.6 402.3 375.0 - 382.5 397.1 340.4 336.7 335.6 342.6 338.4 339.3 325.1 309.4 342.9 384.7 372.4 324.1 349.3 366.1 371.8 423.5 375.3 - 386.9 404.7 349.2 355.0 339.7 361.6 363.9 344.3 343.7 334.2 323.8 364.4 337.4 335.1 302.8 325.9 342.5 361.6 358.1 367.6 342.1 338.0 340.5 302.1 332.9 339.5 336.7 323.8 318.1 ANIMAL STATUS - 1234 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEIG H T S (g) OF P FEMALE RATS DURING LACTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 0 7 14 21 326 .4 345 .3 397 .9 314 .3 389 .8 355,.3 319..5 341..2 393..8 343..0 365..4 394..0 376.,3 345.,4 300..7 292. 1 363. 6 337. 3 303. 1 334. 0 322 .0 361 .1 405 .1 332 .7 380 .7 387 .5 309 .3 350 .5 347,.5 373 ,.1 389..0 400..4 399,.1 352..5 322..0 313.,7 380.,3 356.,5 322. 7 362 .9 349 .3 357 .2 377,.4 341..6 402..1 390..8 349..5 332 .6 393..9 375..7 378..0 358 .0 340..8 345..3 378..4 360..3 FD DAY 112 379..9 355..9 394..7 373,.7 395..7 354,.5 417 .3 382 .0 358..7 328..5 329..5 312 ,.8 332..3 310..1 380. 9 350.,3 368..1 327..6 323..7 302..1 359. 0 335.,4 ANIMAL STATUS - 1235 - Company Sanitized. Does not contain TSCA CBI H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEIGHTS (g) OF P FEMALE RATS DURI N G L A C T A T I O N GROUP: VI-0 DOSE: 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 0 7 14 21 262.3 310.6 354.8 297.6 348.0 310.5 373.3 375.5 -a 356.0 338.8 - 339.1 335.2 305.2 352.7 337.7 383.8 317.1 351.4 281.4 317.5 382.6 306.7 373.2 364.4 365.6 388.7 403.4 378.9 339.0 367.6 346.0 343 .7 365.8 360.0 399.4 333.4 364.3 304.5 332.0 398.5 309.3 386.3 370.8 367.2 389.6 405.8 366.6 364.5 388.9 347.5 346.7 368.8 386.4 393.4 350.4 377.2 298.8 331.2 366.7 315.2 367.0 340.1 343.5 388.2 369.5 352.9 352.4 360.6 346.7 319.9 347.1 378.8 356.1 326.5 355.1 ANIMAL STATUS Data inadvertently not recorded. - 1236- Company Sanitized. Does not contain TSCA CBI H90--2D5a4y25G: aSvuabgechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEIG H T S (g) OF P FEMALE RA T S DUR I N G L ACTATION GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 7 14 21 273.1 366.1 287.2 308.4 371.4 383.7 - 354.3 328.0 304.1 336.6 283.9 357.5 386.5 304.5 280.4 323.2 368.6 338.5 368.3 317.8 397.1 314.4 326.1 387.2 380.3 376.3 350.5 330.4 350.3 298.9 378.1 405.8 330.2 336.0 307.3 387.6 370.5 389.8 322.2 401.3 317.5 346.5 410.3 396.9 385.3 345.2 342.4 369.4 325.8 380.1 418.0 340.6 344.7 371.7 393.8 383.1 387.8 315.0 386.3 320.9 303.4 370.1 368.3 355.1 329.1 331.7 312.4 312.1 363.3 409.0 323.9 345.7 341.0 370.4 369.2 368.7 ANIMAL STATUS - 1237 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX X INDIVIDUAL BODY WEIGHT GAINS OF Pi FEMALE RATS DURING LACTATION - 1238 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note Test days for animal fates are determined from the initiation of test substance administration. Abbreviations FD = Found Dead NP = Not pregnant = No Data - 1239 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations __________________ DuPont-11418 INDIVIDUAL B O D Y W E I G H T GAINS (g) OF P FEMA L E RATS D U R I N G LACTA T I O N GROUP: II-O DOSE: 0 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0-7 7-14 14-21 0-21 19.1 6.2 10.4 2.4 16.8 4.5 7.0 13.8 23.8 - 38.8 17.8 8.1 19.0 -1.8 8.0 -11.5 27.9 21.2 23.0 10.8 11.2 -10.3 15.7 10.6 12.0 18.2 21.2 0.3 4.4 7.6 8.8 18.3 4.1 19.0 25.5 5.0 18.6 24.8 -19.1 -20.3 -35.0 11.0 -46.5 -40.2 -29.3 -61.9 -17.2 -19.3 -62.6 -11.2 -14.5 -37.6 -28.7 -24.4 -7.6 -19.9 -16.1 10.8 -2.9 -34.9 29.1 -19.1 -23.7 -4.1 -26.9 6.9 23.9 -37.2 5.7 22.8 -35.3 -1.7 -10.4 25.3 19.9 31.7 ANIMAL STATUS - 1240 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL BOD Y WEI G H T GAINS (g) OF P FEMALE RAT S D U R I N G L ACTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 0-7 7-14 14-21 0-21 -4.4 15.8 7.2 18.4 -9.1 32.2 -10.2 9.3 -46.3 30.1 23.6 6.4 22.8 7.1 21.3 21.6 16.7 19.2 19.6 28.9 27.3 7.9 16.3 -35.8 -3.0 -11.3 16.8 -16.9 13.2 -18.2 -9.5 -20.0 31.5 4.5 27.9 -18.1 FD DAY :112 6.8 -24.0 5.7 -21.0 -4.7 -41.2 18.2 -35.3 6.2 -30.2 7.5 -16.7 18.6 -22.2 0.6 -30.6 11.6 -40.5 1.0 -21.6 -3.9 -23.6 30.8 -3.7 -7.1 18.3 -14.1 2.7 25.8 19.1 12.9 8.3 -39.5 5.7 -16.9 12.1 18.0 -13.3 -9.7 -1.0 1.4 ANIMAL STATUS - 1241 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEIGHT GAINS (g) OF P FEMALE RATS DURI N G LACTA T I O N GROUP: VI-0 DOSE : 100 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 0-7 7-14 14-21 0-21 19.1 6.9 27.8 9.1 25.2 53.9 -7.7 13.2 ~a 22.9 0.2 ~ 28.5 10.8 38.5 13.1 22.3 15.6 16.3 12.9 23.1 14.5 15.9 2.6 13.1 6.4 1.6 0.9 2.4 -12.3 25.5 - 21.3 1.5 3.0 3.0 26.4 -6.0 17.0 12.9 -5.7 -0.8 -31.8 5.9 -19.3 -30.7 -23.7 -1.4 -36.3 -13.7 -12.1 - -28.3 -0.8 -26.8 -21.7 -7.6 -37.3 -23.9 -22.1 36.5 20.6 11.9 17.6 19.0 29.6 -29.8 12.7 -a -3.1 13.6 " 21.5 11.5 14.7 -5.6 41.1 -27.7 9.4 3.7 ANIMAL STATUS NP Data for interval could not be calculated; data inadvertently not recorded for lacatation day 0. - 1242 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL B O D Y WEI G H T GAI N S (g) OF P FEMALE RATS DUR I N G LACT A T I O N GROUP: VIII-0 DOSE: 1000 MG/KG/DAY LACTATION DAYS: ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 0-7 44.7 31.0 27.2 17.7 15.8 -3.4 - 22.0 22.5 26.3 13.7 15.0 20.6 19.3 25.7 55.6 -15.9 19.0 32.0 21.5 7-14 14-21 0-21 4.4 4.2 3.1 20.4 23.1 16.6 - 9.0 -5.3 12.0 19.1 26.9 2.0 12.2 10.4 8.7 64.4 6.2 12.6 -2.0 -7.2 -15.0 3.4 -43.1 -40.2 -28.6 - -30.2 -16.1 -10.7 -57.0 -13.7 -16.8 -9.0 -16.7 1.0 -30.7 -23.4 -13.9 -19.1 41.9 20.2 33.7 -5.0 -1.3 -15.4 0.8 1.1 27.6 -24.2 28.2 5.8 22.5 19.4 65.3 17.8 1.8 30.7 0.4 ANIMAL STATUS - 1243 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX Y INDIVIDUAL FOOD CONSUMPTION OF Pi FEMALE RATS DURING GESTATION - 1244 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL FOOD CONSUMPTION OF Pi FEMALE RATS DURING GESTATION EXPLANATORY NOTES Abbreviations NP = Not Pregnant; excluded from statistical analyses. - = No Data - 1245 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL POOD CONSUMPTION (g/day) BY Pi FEMALE RATS DURING GESTATION GROUP: II-O DOSE: 0 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665220 665334 665257 665175 665336 665192 665232 665307 665246 665289 665264 665185 665206 665306 665226 665198 665249 665284 665240 665203 0 -1J 7-14 14-21 0-21 20.3 24.0 - 22.0 22.5 22.1 22.8 26.4 24.8 25.0 23.2 25.9 24.4 23.8 24.2 20.8 23.0 22.0 18.9 20.0 23.7 28.8 25.0 24.7 26.9 29.9 28.5 28.2 26.7 23.5 29.1 25.1 28.3 24.8 20.2 23.8 24.9 26.9 26.1 23.1 28.4 25.6 23.7 26.9 31.7 30.5 27.8 30.5 22.9 28.3 25.7 27.4 28.0 23.3 26.8 23.1 26.9 23.1 22.4 ' 27.1 24.2 23.7 25.3 28.1 28.5 26.9 27.4 23.2 27.8 25.1 26.5 25.7 21.4 24.5 23.3 24.2 23.1 ANIMAL STATUS a NP aEvidence ofcopulation was not observed, but animal delivered a litter. - 1246 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL FOO D CONSUM P T I O N (g/day) BY Pi FEM A L E RATS D U R I N G GESTATION GROUP: IV-0 DOSE: 10 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665212 665180 665292 665187 665205 665263 665210 665181 665248 665293 665329 665290 665253 665286 665281 665186 665330 665294 665244 665258 0-7 7-14 14-21 -21 19.0 25.3 26.5 24.8 25.9 - 21.5 - 22.6 23.9 22.0 22.9 26.3 30.8 20.8 23.2 27.1 20.2 20.3 23.3 23.4 26.3 26.9 26.6 29.3 - 21.9 - 27.7 26.6 28.3 28.7 29.5 34.2 25.5 27.4 29.1 27.5 21.3 26.8 28.2 26.2 25.2 25.1 28.1 - 22.3 - 23.1 27.9 25.2 27.1 29.4 29.2 24.2 23.5 26.6 30.8 24.3 27.8 23.5 26.0 26.2 25.5 27.8 21.9 _ 24.5 26.1 25.2 26.2 28.4 31.4 23.5 24.7 27.6 26.1 22.0 26.0 ANIMAL STATUS a a aEvidence of copulation was not observed, but animal delivered alitter. - 1247 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL P O O D C O N S U M P T I O N (g/day) BY P x FEMA L E RATS D U R I N G GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665338 665219 665267 665325 665331 665217 665227 665262 665247 665243 665312 665298 665207 665273 665274 665272 665195 665314 665316 665173 0-7 7-14 14-21 0-21 19,.6 22,.2 25,.6 19,.8 22,.2 23,.1 26,.2 24,.6 28,.5 23,.6 23,.6 19,.8 26,.0 21,.6 18,.5 25,.2 26,.1 29,.1 21,.1 26,.2 24 .3 24,.1 29,.1 22,.5 22,.5 24,.5 28,.6 31,.0 33 ,.1 24..8 26,.0 23 .1 28..1 26,.0 22 .4 29..2 27 ,.1 33 ,.4 20..9 28..1 21..8 24..1 28..5 23..4 27..2 23..1 28..6 24..7 31..3 25..0 26..0 21..5 25..9 24..7 22.,3 28.,8 27.,5 28.,1 23.,0 31.,9 21 .9 23,.5 27,.7 21,.9 24,.0 23..6 27,.8 26,.8 31,.0 24..4 25..2 21..5 26.,7 24..1 21.,1 27.,7 26..9 30.,2 21..7 28.,7 ANIMAL STATUS - 1248 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL FOOD C O NSUMPTION (g/day) BY Pj. FEMALE RATS D U R I N G G E S T A T I O N GROUP: VIII-0 DOSE: 1000 MG/KG/DAY GESTATION DAYS: ANIMAL NUMBER 665296 665193 665320 665315 665318 665279 665224 665254 665245 665322 665214 665321 665171 665265 665169 665191 665231 665255 665213 665280 0-7 7-14 14-21 0-21 27.2 21.8 25.1 25.4 23.2 25.3 22.1 20.1 21.8 24.0 23.8 24.2 21.4 21.5 20.6 27.1 26.2 - 29.6 24.0 28.9 31.0 22.0 27.6 24.1 21.9 21.5 23.2 26.9 28.2 24.0 25.7 25.1 27.1 25.8 - 27.4 - 25.1 29.6 32.1 22.2 26.8 26.0 24.0 24.1 25.6 27.6 27.1 25.2 24.9 26.3 28.5 27.7 _ 28.1 - 23.6 27.9 29.5 22.4 26.6 24.0 22.0 22.5 24.3 26.1 26.5 23.6 24.0 24.0 27.6 26.6 - ANIMAL STATUS a a NP a aEvidence of copulation was not observed; therefore, no gestation data were collected. - 1249 - Company Sanitized. Does not contain TSCA CB1 H90--2D5a4y25G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________ DuPont-11418 APPENDIX Z INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P, MALE RATS - 1250 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL SPERM MOTILITY D A T A IN Pi MA L E RATS GROUP 1-0 0 mg/kg/day GROUP III-O 10 mg/kg/day Animal Number Percent Motile Animal Number Percent Motile 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 69 92 98 95 94 94 68 88 77 85 665153 665037 665163 665001 665126 665125 665017 665071 665032 665997 86 98 97 96 81 79 98 74 89 94 GROUP V-0 100 mg/kg/day GROUP VII-0 1000 mg/kg/day Animal Number Percent Motile Animal Number Percent Motile 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 94 94 96 96 97 74 77 91 92 97 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 94 89 96 84 82 93 92 95 87 84 - 1251 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 APPENDIX AA INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS - 1252 - Company Sanitized. Does not contain TSCA CBI H-25425 : Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DA T A IN Pi MALE RATS Group 1-0: 0 mg/kg/day Animal Number 665144 665104 665044 665141 665135 665005 665075 665091 665040 665069 Total Normal 199 199 200 200 199 197 196 200 200 198 Tail Abnormal 0 0 0 0 0 0 0 0 0 0 Head Abnormal 0 1 0 0 1 3 4 0 0 2 Tail & Head Percent Abnormal Normal 1 99.5 0 99.5 00 100.0 100.0 0 99.5 0 98.5 0 98.0 00 100.0 100.0 0 99.0 Animal Number 665153 665037 665163 665001 665126 665125 665017 665071 665032 665997 GROUP III-O: 10 mg/kg/day Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 194 0 193 0 200 0 198 0 200 0 200 0 200 0 199 0 199 0 200 0 6 7 0 2 0 0 0 1 1 0 97.0 96.5 100.0 99.0 100.0 100.0 100.0 99.5 99.5 100.0 - 1253 - Company Sanitized. Does not contain TSCA CBI H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-11418 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Px MALE RATS Group V-0: 100 mg/kg/day Animal Number 665116 665034 665051 665083 665124 665078 665036 665085 665092 665004 Total Normal 199 198 197 199 200 198 199 195 200 198 Tail Abnormal 0 0 1 0 0 0 0 0 0 0 Head Abnormal 1 2 3 1 0 2 1 5 0 2 Tail & Head Percent Abnormal Normal 0 0 0 0 0 0 0 0 0' 0 99.5 99.0 98.0 99.5 100.0 99.0 99.5 97.5 100.0 99.0 Animal Number 665134 665022 665105 665102 665161 665133 665157 665093 665059 665123 GROUP VII-0: 1000 mg/kg/day Total Tail Head Tail & Head Percent Normal Abnormal Abnormal Abnormal Normal 196 0 199 0 200 0 195 0 199 0 198 0 196 1 197 0 200 0 200 0 4 1 0 5 1 2 2 3 0 0 0 98.0 0 99.5 0 100.0 0 97.5 0 99.5 0 99.0 1 98.0 0 98.5 0 100.0 0 100.0 - 1254 - Com pany Sanitized. D oes not contain T S C A C B I