Document 3Q1e1wvw7g1pvmLjvnBvgD3JO

) FOR COMMITTEE USE nNLY ) NOT FOR PUBLICATION AMERICAN PETROLEUM INSTITUTE DIVISION OF SCIENCE AND TECHNOLOGY MINUTES . ____ MEDICAL ADVISORY COMMITTEE " 34TH MEETING 9:00 A. M. Sunday, November 11, 1962 Conrad Hilton Hotel Chicago, Illinois MEMBERS PRESENT: R. F. Schneider, M. D., Chairman G. H. Collings, Jr., M. D., Vice Chaiman J. W. Hammond, Secretary T. E. Allen, M. D. V. C. Baird, M. D. C. H. Baylor, M. D. F. F. Boys, M. D. Kieffer Davis, M. D. F. D. Gassaway, M. D. T. J. Kelly, M. D. J. W. Osborn, M. D. ' M. R. Plancey, M. D. Frank Princi, M. D. S. L. Rankin, M. D. J. C. Ruddock, M. D. C. L. Samuelson, M. D G. M. Saunders, M. D. H. B. Snyder, M. D. TECHNICAL ADVISORS PRESENT: W. H. Barcus . E. K. Daniels A. E.. Dooley Harold Elkin H. W. Gerarde, M. D. P. D. Halley N. V. Hendricks A. C. Pabst J. B. Rather, Jr. J. A. Spence MEMBERS ABSENT: J. W. Crookshank, M. D. L. E. Curtis, M. D. R, R. Dugan, M. D. R. E. Eckardt, M. D. K. R. Fourcher, M. D. E. V. Henson, M. D. R. Emmet Kelly, M. D. E. K. Linder, M. D. OTHERS PRESENT: E. P. Luongo, M. D. B. S. Miller, M. D. R. J. Potts, M. D. G. A. Sinclair, M. D. Kendrick Smith, M. D. W. W. Stewart, M. D. R. A. Vise, M. D. EB 007125 E. 0. Mattocks - American Petroleum Institute, New York, Nev_York D. W. McNaughton, M. D. - U. S. Public Health Service, Chicago, Illinois I. INTRODUCTORY REMARKS The chairman welcomed the members present. He introduced Frank Princi, of Ethyl Corporation, who replaced L. W. Sanders, M. D., recently retired, csted the following additional changes: E. Wade Adams, retired, and ^vl.sSi API 0776c SC-API-3450 )) -- APPROVAL OF MINUTES ' ACTION: It vas regularly moved, seconded, and unanimously passed that the April 7, 19^2 minutes be approved as distributed. III. REPORT OF SUBCOMMITTEE CHAIIMEN *" . A. Operating Subcommittee Chairman Schneider reported on the actions of the Operating Subcommittee. A copy of the minutes of this meeting are attached as Appendix A. ACTION: It vas regularly moved, seconded, and unanimously passed, that the report be accepted. E. Atmospheric Pollutants Dr. Samuelson reported on the activities of his group. The minutes'of his subcommittee are attached as Appendix B. ACTION: It vas regularly moved, seconded, and unanimously passed that the report be accepted. C. C9 - C12 Aromatics . . Kieffer Davis, M. D. reported that the experimental work on Cn - C]_2 aromatics has been terminated. They vere waiting for the final report from Dr. Nau. ACTION: It vas regularly moved, seconded, and unanimously passed that the report be accepted. D. Certificates of Appreciation R. F. Schneider, M. D. reported for R. E. Eckardt, M. D., Chairman of the subcommittee, who vas unable to be present. Based on the recommendations of the subcommittee, vhich vere approved by the Operating Subcommittee of the Medical Advisory Committee, C. E. Spahr, Chairman of the General Committee of the Division cf Science and Technology, vas presenting on Monday morning, November 12th, at the General Committee meeting, Certificates of Appreciation to Kieffer Davis, M. D., H. V. Gerarde, M. D., and J. W. Osborn, M. D. . ' ACTION: It vas regularly moved, seconded, and unanimously passed that the report be accepted. E. Dermatology J. W. Osborn, M. D. reported on the activities of his group. The minutes of this meeting are attached as Appendix C. ACTION: It vas regularly moved,'seconded, and unanimously passed" ' that the report be accepted. F. Epidemiology EB 007126 ' C-ecrge M. Saunders, M. D., Chairman, reported that there vas nc activity API 07769 ACTION: It-was regularly roved, seconded, ar.d unanimously passed that the report "be accepted. 0. Industrial Hygiene Dr. J. A. Spence reported on the activity of his group; The minutes of his subcommittee meeting'are attached as Appendix D. ACTION: It vas regularly moved, seconded, and unanimously passed that the report be accepted. H. Medical Policies and Administrative Practices '- V. C. Baird, M. D., Chairman of this subcommittee, reviewed the activities of his group. The minutes of this subcommittee are attached as Appendix E. ACTION: It was regularly moved, seconded, and unanimously passed, that the report be accepted. I. Oil Mist . N. V. Hendricks, Chairman of this subcommittee, reviewed the activities of his group. The minutes of his subcommittee are attached as Appendix F. ACTION: It was regularly moved, seconded, and unanimously passed that the report be accepted. J. Physical Agents G. H. Collings, Jr., M. D. reported on the activities of his subcommittee. The minutes of the subcommittee are attached as Appendix G. ACTION: It was regularly moved, seconded, and unanimously passed that the report be accepted. .. K. Specialty Petroleum Products C. H. Baylor, M. D. reported on the activities of this subcommittee. The minutes of the meeting of his group are attached as Appendix H. The Operating Subcommittee recommended that $2,000 be transferred from Dr. McKay, at the University of Vermont, to Dr. Mintz, at Baylor University, in order that Dr. Mintz could continue his toxicity studies on the ingestion of petro leum products. . ACTION: It was regularly moved, seconded, and unanimously passed that the $2,000 received from Dr. McKay be transferred to . Dr. Mintz and the report be accepted. L. Toxicological Reviews EB 007127 K. W. Gerarde, M, D., Chairman of the Subcommittee on Toxicological Reviews, reported or. the activities of his group. His report is attached as Appendix I> . ACTION was regularly moved, seconded, ar.d unanimously passed at the report be accepted. API 07770 I -k. V. REPORT OF LIAISON MEMBERS A. Air and Water Conservation Committee C. L. Samuelson, M. D. reported excellent cooperation with other groups ir. the API who are concerned with air pollution. He indicated that it would toe desirable to work more closely with the various projects that have possible health aspects. . Asphalt Dr. J. A. Spence reported on the first meeting of the Asphalt Comnittee. A copy of the report of the Ir.terdivislonal Committee on Asphalt, to the General Committee of the Division of Science and Technology is attached as Appendix J. C. First Aid Training H. B. Snyder, M. D. has reported to the Fire and Safety Committee relative to their questions as to the advisability of including the closed chest heart massage in first aid training courses in industry. A copy of his letter to the Fire and Safety Committee is attached as Appendix K. D. Interdivisional Committee on Labeling A. E. Dooley, Chairman of the Interdivisional Committee on Labeling, reported on the activities of this group. A copy of his report is attached as Appendix L. . E. National Poison Prevention Week J. W. Osborn, M. D., who was appointed liaison with the National Poison Prevention Week, reported on his activities. A copy of his.report is attached as Appendix M. F. Interdivisional Committee on Petroleum Food Additives L. E. Curtis, M. D., Chairman of the Interdivisional Committee on Petro leum Food Additives, was unexpectedly called hone. Mr. J. B. Rather, Jr. reported on the activities of this group. A copy of the report of the Interdivisional Committee on Petroleum Food Additives activities to the General Committee is. attached as Appendix N. , G. Quarantine Service EB 007128 G. M. Saunders, M. D. reported on his activity as liaison with the U. S. Public Health Service, Quarantine Service. A copy of his report is attached as Appendix 0. Dr. Saunders introduced D. W. McNaughton, M. D., U. S. Public Health Service, Chicago, Illinois, who was invited to attend this meeting. Dr. Saunders stated that Dr. McNaughton would give the group a review of the Quarantine Service activities later in the meeting. H, Wax .ttse API 07771 Re seer R kar dt, M. D., Chairman of the Advisory Committee to the Wax VS 5 ur.able tvow be present. R. F. Schneider, M. D. read ' r> Dr. Eckardt's report to the Gene: as Appendix P. * 'omnitces. A :opy of the report is etteched VI. REPORT TO GENERAL CCMMITTZE A copy of the report of the Medical Advisory Committee to the General Committee is attached as Appendix Q. VTI. 1963 BUDGET As explained in the Operating Subcommittee minutes, the final budget approved by the API Program and. Budget Review Committee and the Executive Committee . of the. Board of Directors was $42,000 for continuation of the Chicago Medical School investigation on the toxicity of hydrocarbons in lungs and $2,500 as a contribution toward research on noise. . VIII. REV BUSINESS . A. Form of Subcommittee Meetings ' Chairman Schneider asked how the Medical Advisory Committee members liked having the subcommittees meet consecutively. The general consensus was that the recent meetings of the subcommittees, where this was tried, was very successful. They recommended that it be continued for the 1963 spring committee meetings. Dr. Schneider asked each chairman to let the API staff know, as soon as possible, if they were planning to have a meeting in Washington at the time of the new Central Committee on Medicine and Health meeting. B. Next Meeting . . As recommended by the Operating Subcanmittee and as reported in its minutes, it appeared desirable to hold the Medical Advisory Committee meeting in conjunction with the Industrial Health Conference. ACTION: It was regularly moved, seconded, and unanimously passed that the meeting of the Central Committee on Medicine and Health would be held in conjunction with the Industrial . Health Conference Monday, March 18, 1963, with the Executive Committee meeting held Sunday night, March 17, 1963, prior to that, and the subcommittee meetings to be held Friday and Saturday,. March 15 and l6, 1963. . 0. National Conference on Air Pollution EB 007129 Dr. Schneider announced that the National Conference on Air Pollution Is to be held in Washington, D. C., Decmber 10 to 12. . D. Dr. Schneider asked Dr. McNaughton'if he would review the activities of the Quarantine Service of the U. S. Public Health Service. The group greatly appreciated the information given by Dr. McNaughton. IX. ADJOURNMENT The meeting adjourned at 11:35 A. M. API 07772 V jeers: = - -_ v i I r* i APPENDIX A ' r:R COMMUTES USE ONLY AMERICAN PETROLEUM INSTITUTE DIVISION OF SCIENCE,AND TECHNOLOGY NOT POP PUBLICATIO MINUTES OF THE. MEDICAL ADVISORY COMMITTEE'S OPERATING SUBCOMMITTEE ` 6:00 P. M. Saturday, November 10, 1962 Crr.rad Hilton Hotel, Chicago, Illinois MEMBERS PRESENT: R. F. Schneider, M. D., Chairman G. H. Collings, Jr., M. D., Vice Chairman J. W. Hammond, Secretary V. C. Baird, M. D. C. H. Baylor, M. D. L. E. Curtis, M. D. (PFA) Kieffer Davis, M. D. A. E. Dooley (ICL) H. W. Gerarde, M. D. N. V. Hendricks E. 0. Mattocks (ex-officio) J. W. Osborn, M. D. C. L. Samuelson, M. D. G. M. Saunders, M. D. (Represented by T. E. Allen, M. D.) J. A. Spence MEMBER ABSENT: R. E. Eckardt, M. D. I. INTRODUCTORY REMARKS BY CHAIRMAN Chairman Schneider reported that R. E. Eckardt, M. D. was unable to attend the meeting because of illness in his family. . The chairman distributed copies of his proposed report of the Central Committee on Medicine and Health to the General Committee. Two minor suggestions were incorporated. A copy of the final report is attached. . ( The chairman announced that he hoped to establish an Executive Committee to replace the Operating Subcommittee of the Medical Advisory Committee. The Executive Committee will consist of the officers of the Central Committee, the chairmen of the committees reporting to the Central Committee, and the physicians who are members of the General Committee. j II. APPROVAL OF MINUTES ACTION: It was regularly moved, seconded, and unanimously passed chat che minutes of the Operating Subcommittee meetingrheld April 7, 1962, be approved as distributed. III. RETORTS OF SUBCOMMITTEE CHAIRMEN EB 007130 p~ arts API 07773 I C, Zj, Sanue r, s ^ v 3 c -* 3 r. M. D- ; Chairsar., stated that the only policy natter r.g the 3pparer.t duplication of effort by several groups T A-2 within the API. He questioned whether any action was needed by the Medical Advisory Committee to attempt to reduce this duplication. It was generally agreed that the Committee on Atmospheric Pollutants should request from the other API committees concerned with air pollution representatives who would attend the Committee on Atmospheric Pollutants meetings. Likewise, it was hoped that the other committees would invite one or more physicians to be members of their committees. It was anticipated that this would result in eliminating or reducing to a minimum duplication of effort. B. Dermatology J. W. Osborn, M. D., Chairman of the Subcommittee on Dermatology, requested assistance as to what should be done to review the industry's health problems as they relate to skin, such as skin cancer, dermatitis, etc. The group agreed generally that this was a problem of the Subcommittee on Derma tology and should, if they think it desirable, Trequest appointment of the necessary task group to review the complete problem. C. Specialty Petroleum Products i C. H. Baylor, M. D., Chairman of the Subcommittee on Specialty Petro i leum Products, stated that Dr. Mintz, Baylor University, needed approximately $2,000 to continue his study on toxicity of petroleum products, such as furni ture polishes and detergents. Dr. Baylor contacted Dr. McKay, at the Univer sity of Vermont, who had not been able to use much of the funds given him because of the.reduced number of kerosine poisoning.cases.in that area. Dr. Baylor requested Dr. McKay to return to the API $2,000 of the money which f he had. Since there were no funds in the 1963 budget for Dr. Mintz, the $2,000 returned by Dr. McKay could be given to Dr. Mintz. ACTION: It was regularly moved, seconded, and unanimously passed that the $2,000 returned by Dr. McKay, University of Vermont, be given to Dr. Mintz, at Baylor University, to continue his investigation on the ingestion of petroleum products. . . D. . All the other subcommittees reported that they had no policy matters or financial problems to bring up at this time. !V. 1963 BUDGET Chairman Schneider reported that the API Program and Budget Review Committee had removed from the recommended 1963 Medical Advisory Committee bud get $5,000 for a critical review of atmospheric pollution literature, $10,000 for the oil mist epidemiological studies, and $2,000 for consulting fees. They approved $42,000 for continuation of the work at the Chicago Medical School on the study of hydrocarbons in lungs, and $2,500 for the contribution to the study of noise. ' I- V. PHYSICIAN FOR API STAFF EB 007131 M Chairman Schneider reported that the budget item for the hiring of a physician to be placed on the Division of Science and Technology.staff to ser vice the activities of the new Central Committee on Medicine and Health had . API 07774 ) '' . "3- 1 - A-3 beer, approved by the API Program' and Budget Review Comm;ttee and the Executive Committee of the Board of Directors. It has yet to be approved by the Board of Directors at their meeting on November,lUth. In anticipation of the Beard of Directors approval, the chairman appointed a special task group, with R. E. Eckardt, M. D. as chairman, L. E. Curtis, M. D., Kieffer Davis, M. D., and George Saunders, M. D. This task group has reviewed a number of applications. They have selected three prospective candidates to be interviewed by the phy sicians in this metropolitan area and by the API staff. It is possible that a physician may become a member of the staff soon after the first of the year. VI. NEW BUSINESS '. . There was no new business. VII. NEXT MEETING . ' The group reviewed the possibility of having the next meeting of the Central Committee on Medicine and Health in conjunction with the Industrial Health Conference, which is to be held March 19-21, 1963, in Washington, D. C. Ihe possibility of holding the meetings at the time of the Industrial Hygiene Conference, which will be held in Cincinnati about the second week of May, was also considered. ' ACTION: It was regularly moved, seconded, and unanimously passed that the Central Committee on Medicine and Health hold its meeting on Monday., March l9, 1963, in Washington, D. C,, and the Executive Committee meeting on Sunday evening, March 17th, in conjunction with the Industrial Health Conference. . VIII. ADJOURNMENT The meeting adjourned at 9:25 P. M. J. W. Hammond, Secretary Approved: R. F. Schneider, M. D., Chairman 007132 API 07775 11 ATTACHMENT REPORT GF THE CENTRAL COMMITTEE CL MEDICINE AND HEALTH _____ TC Tig ,. GENERAL COMMITTEE,. El VI SION C? SCIENCE AND TECHNOLOGY ' ' R. F. Schneider, M. D., Chairmen At the first meeting of the Ger.erel Committee of the Division of. Science and Technology, a suggestion was made that a Central Committee on Medicine and Health be established to supervise all of the health activities in the API. C. E. Spehr, Vice President for the Division and Chairman of the. General Committee, requested Eieffer Davis, M. D. to prepare a reconmendation for the Operating Committee of the General Committee requesting the establish ment of a Central Committee on Medicine and Health. Dr. Davis' recommendation was accepted. In order to firm up the organization of the Central Committee . on Medicine and Health and develop a proposed organization of committees re porting to it, C. E. Spahr, Chairman of the General Committee, designated the membership on the new Central Committee on Medicine and Health. This group has met and has unanimously recommended the following organization. Purpose and Scope The purpose of the Central Committee on Medicine and Health is to be concerned with all matters relating to the products and operations of the petro leum industry as they affect the health of its employees, its customers, and the public. Such matters may originate either within the Central Committee on Medicine and Health or be initiated and referred to this committee by any of the other divisions or officers of the APT. With this scope, the central com mittee, at present, will be responsible for the activities of five.of the groups which now report to the General Committee.- These are: Asphalt, Labeling, Medical Advisory Committee, Petroleum Food Additives, and Wax. Organization EB 007133 . The Central Committee on Medicine and Health has reviewed carefully the activities of the five groups which are presently concerned with medicine and health matters who had reported to the General Committee of the Division of Science and Technology. As a result, it is suggested that these five groups be reorganized to form committees on: Asphalt, Atmospheric Pollutants, Clini cal Practices, Industrial Hygiene, Precautionary labeling, Petroleum Food Addi tives, Toxicology, and Wax, each of which will report to the Central Committee on Medicine and Health. ' Since it- is possible that tne Food and Drug Administration will issue a regulation on the use of petroleum waxes as food additives.in the very near future, the activities of the Wax Committee will be virtually eliminated and the committee dissolved. The suggested Committee on Clinical Practices will embrace the activities previously done by two other subcommittees and will in clude medical practices, record keeping, and epidemiology. The new Committee or. Industrial Hygiene will include the activities previously handled by four subcommittees and will include oil mist, physical agents, dermatology, and in dustrial hygiene. The Committee or. Toxicology will induce work cone by two previous subcommittees, namely. Toxicological Reviews ar.d Specialty Petroleum Products. r.is s-_;:ces Z=~ 1 API 07776 l 1 -2 A-5 L Hie committee has prepared a list of suggested membership for these eight proposed committees. This membership is composed of those people with interest and experience in these fields and who have been on the previous subcommittees. It is felt that tne proposed reorganization will result in an increased efficiency in the operations of the Central Committee on Medicine and Health. \ I ) i i i zr.'emcer 12, .19:<2 ' EB 007134 hr; )1 REPORT OF SUBCOMMITTEE ON ATMOSPHERIC POLLUTANTS r C"! l! Samuel son, M. D. , Chairman APFENIO 3 The Subcommittee on Atmospheric Pollutants met all day Saturday, November 10, 1962, at the Conrad Hilton Hotel, in Chicago, Illinois. The first discussion dealt with the problem of atmospheric sulfur compounds, tr.e USFHS concern over the same, and some of the evidence new cut which we felt was r.ot too convincing. Mr. Elkin, of the Sun Oil Company, raised several good questions regarding the recent article of Dr. Pohan. These questions will serve as a guide to the subcommittee in it's further evalu ation of the problem. '. Dr. Shubik and associates, Dr. Saffiotti and Dr. Lijinsky, gave us our first report on the research work that we are sponsoring. This was an excellent presentation. Dr. Shubik outlined the work to date, Dr. Saffiotti presented slides showing what happens to Fe02 and carcinogens in the lungs of hamsters. Dr. Lijir.sky discussed the chemical analyses of residual FeO^ and carcinogens in the lung tissue. Dr. Shubik then outlined the work they noped to carry on in the future. Dr. Donald Diggs, of the du Pont Company and a member cf the working group of the three city Lead Study Committee, brought us up to date on the study, some of the facts and figures now becoming available, and some of the possible conclusions that might be drawn from the same. The final report should be ready sometime between September and December. . Dr. Princi and Mr. Hall,, of the Ethyl Corporation, presented a paper and discussed the new weathering technique of TEL containing sludge. . Dr. Batchelder, of. the California Research Corporation and Chairman of the Research Advisory Committee of the Air and Water Conservation Committee, attended our entire meeting and told us of their committee's work in the field cf air pollution. This included their budget, the nature of their work and where it was being done. The liaison between the various committees of the Air and Water Con servation Committee and our group has been excellent during the past six months. We hope to further and even possibly strengthen this cooperation. There is only one item that required action on the part of the Medical Advisory Committee. The subcommittee recommends the filing of the Goldblatt Report in the National Archives, at Washington, D. C. . C. L. Samuelson, M. D. , Chairman EB 007135 API 07773 ) REPORT OF SUBCOMMITTEE ON DERMATOLOGY J. W. Osborn, M. D., Chairman APPENDIX ^ The subcommittee met at the Conrad Hilton Hotel, Chicago, at 9:30 a.m., Friday, November 9 1962. MEMBERS PRESENT: MEMBERS ABSENT: J. W. Osborn, M. D., Chairman C. H. Baylor, M. D. R. C. Burton, M. D. A. E. Dooley R. R. Dugan, M. D. F. D. Gassaway, M. _D B. S. Miller, M.. D. H. B. Snyder, M. D. This was the first subcommittee meeting under the new schedule for meeting consecutively rather than separately so practically the entire member ship and technical advisors who were present in Chicago were guests of the I subcommittee. !. . . ) The chairman read his memorandum of October 22, 1962, addressed to I subcommittee members. 1. RESULTS OF LIAISON WITH DR. FLOYD VAN ATTA. RE: CUTTING OIL SKIN PROBLEMS Mr. A. C. Pabst, successor to Mr. M. D. Gjerde, Chairman, Hygiene Panel, Lubrication Committee, Division of Marketing, had not had occasion to contact Dr. Van Atta so Dr. Osborn had called him by.phone, October 15th. No new cases of cutaneous cancer have been uncovered and interest aroused within U.A.W. a few years ago after four cases were discovered has quieted down. He needs no teachers from API for his Summer School Sessions for Union Stewards, but would appreciate up to 1700 more Industrial Hygiene' Foundation brochures on "Good Plant Practices in Preventing Dermatitis" and the accompanying wallcharts for Summer School Sessions starting between May 15 and June 1-5, 1963- ACTION: The subcommittee moved, seconded, and unanimously approved sending 1700 brochures and wall-charts to Dr. Van Atta in time for his 1963 Summer School Sessions. ' Dr. Van Atta raised another question regarding the presence of disr infectants and germicides in cutting fluids. He believes the breakdown products into formaldehydes, phenols, etc. result in more dermatitis ther would occur from cutting fluids without these additives. After much discuesion, the sub committee decided that cutting fluid disinfectants and germicides were valuable additions to the mixtures if the customer followed instructions of the supplier and did not permit on-the-job additions of extra amounts of disinfectants and germicides. The subcommittee authorized its chairman to communicate these ob servations to Dr. Van Atta stressing that good plant hygienic practices were the key to safe use of cutting fluids based upon the recommendations for_ use of the particular cutting fluid by its supplier. - II. LIAISON WITH U. S. PUBLIC HEALTH SERVICE EB 007136 The subcommittee chairman has been in contact with Dr. Donald Birmingham, Occupational Health Field Service, Cincinnati, Ohio; No new ApI 07779 problems have arisen in this area other than ar. informal request for informa -ion on tne role of barrier creams in prevention of dermatitis in industry which was made recently by Dr. Hoffmann of Food and Drug Administration to Mr. A. E. Dooley. Itae subcommittee chairman will discuss this request with Dr. Birmingham in hope of suggesting better liaison between various branches of the Department of Health, Education, and Welfare and learning whether Dr. Birmingham believes there may be a problem. III. API STUD! ON CARCINOGENICITY OF CUTTING FLUIDS Although no new cases of cutaneous cancer, associated with the use of cutting fluids among the industry's consumers, have recently been reported to the AH, there remains considerable belief among subcommittee members that - potential problem exists. A few member companies have initiated research projects on a company basis. Kie consensus of the Subcommittee on Dermatology is that an.industry-wide problem persists in this area which should be researched by the API, but the subcommittee is not prepared at this time to propose a spe cific research study. Its chairman has been invited to meet with the Ifygiene Panel, Lubrication Committee, Division of Marketing, on Monday, November 12, 1962, and will further explore this subject. Following that meeting, the Subcommittee on Dermatology anticipates it will recommend to the Chairman of the Medical Advisory Committee that the new Central Committee on Medicine and Health form a special Ad Hoc Study Group on Cutting Fluids, with representa tion from all interested API divisions, to decide whether an industry problem exists and to recommend appropriate action: J. W. Osborn, M. D., Chairman EB 007137 '> 1 . SUBCOMMITTEE CN im'S TRIAL HYGIEIiE J. A. Spence, Ph. D. , Chairman AFPEKDIX D The Subcommittee on Industrial hygiene met on November 9, 1962. . Liaison members to the American Standards Association reported on the activities of the Z-62, Z-37 and Z-1* Committees. No significant activi ties have occurred since the last report. - The subcommittee's report "industrial ffygiene Aspects of Petroleum Refining Processes" is complete. Mr. E. 0. Mattocks has. been asked to dis tribute the report within the membership of the API. A questionnaire to determine laboratory hood requirements has been prepared and will be distributed to the medical directors of the API. The results will be compiled as a guide to member companies seeking an economic approach to effective hoods. The chairmen reported on the activities of the Asphalt Committee and asked the subcommittee members to aid in obtaining data evaluating envi ronmental exposures to asphalt. The subcommittee has no items requiring budgetary expenditures. J. A. Spence, Ih.D., Chairman EB 00713B API 07781 11 - APPENDIX E SUBCOMMITTEE ON MEDICAL POLICIES ASP AIMINISTRATIVZ PRACTICES ~ V. C. Baird, M. D ., Chairman ~ '. . ^ It is recommended that the "Guiding Principles in Regard to the Scope Objectives', and Functions of Occupational Health Programs in Petroleum Opera tions", as previously approved by the Medical Advisory Committee in i960, be published in suitable form by the API Division of Science and Technology,'and that appropriate notice be given members of APE through the API Newsletter that this publication, is available on request for their guidance: It is proposed that physician members of the Medical Advisory Com mittee be encouraged to submit through the staff of- the. Central Committee on Medicine and Health any information on medical practices or policies that, in their opinion, might be of interest to other medical departments. After review this material may be reproduced and distributed to the medical departments of member companies. ' ' . ' V. C. Baird, M. D., Chairman F. F. Boys-, M. D. . T. J. Kelly, M. D. .. J. P. Malia, M. D. G. M. Sawders, M. D. G. A. Sinclair, M. D. EB 007139 API 07732 1 . APPENDIX F REPORT. OF SUBCOMMITTEE ON OIL MIST N. V. Hendricks, Uiairman The Subcommittee on Oil Mist net November 9,-1962 and the following summarizes the highlights of' these discussions. .. 1. The best available information on occupational exposures to oil mi6t has been reviewed ar.d a summary of this has been published. 2. Close liaison has been maintained with Dr. StokLnger of the Public Health Service and his animal studies' on oil mist inhalation. These studies have been about completed with essentially negative results. An appendix is ' attached which gives the important observations to date on this work. 3. Three test oils have been prepared and submitted to Dr. Stokinger for study. The first of these will be put under test in January 1963 and the other two will be started as soon as space in exposure chambers becomes available. 4. Discussions have been held with representatives of Eastman Kodak Company concerning an epidemiological study of workers exposed to oil mist in their machine shops. Eastman has agreed to do such a study .and to publish-the results. ' 5. Concern has been expressed over possible exposures to diesel oil vapors associated with mixing this fuel in explosive preparations. The Univer sity of Toronto is to do animal studies on diesel fuel and the Oil Mist Subcommittee has supplied a sample of diesel oil representative of the current Canadian market. These.studies will be followed by the Oil Mist Subcommittee. . ' N. V.Hendricks, Chairman EB 007140 API 07733 )) F-2 APPENDIX TO REPORT OF OIL MIST SUBCOMMITTEE SUMMARIZING VISIT WITH DR. STOKINGER AT PUBLIC HEALTH SERVICE LABORATORIES . On November 9, 1962 a visit was made to the Public Health Service Laboratories in Cincinnati, ar.d the animal studies on oil mist Inhalation vere. . reviewed with Dr. Stokinger and his associates. The following describes the important observations to date. 1. Design of the Studies A. Animals - Several species have been'exposed including rata, hamsters, dogs and rabbits. .- B. Oils Used in Tests - The oil used for the base line studies reported here is a light mineral oil NF obtained locally from a drug store. Three test cutting oils have been submitted to Dr. Stokinger by the Committee and these incluae (a) a sulfurized oil made from a 100' SUS/100#F. Bcid treated naphthenic stock; (b) a 100' solvent refined naphthenic oil; and (c) an emulsifiable', but not sulfurized oil made from a 100' SUS/100F. acid treated naphthenic stock. C. Exposure Conditions - Particle size of oil droplets is controlled to . a range of Q.b-1.2 micron. Animals have been exposed at two levels of 5.0 mg/M^ and 100 mg/M^'. Exposures have been carried put for six hours a day, five days a week. Animals exposed at the level cf 5.0 mg/M^ were carried for 12 months, while the tests run at 100 mg/M- were carried for 2k months. D. Experimental Criteria - In evaluating the response to oil mist, mea surements and observations have been made in the areas of (a) bio chemistry; (b) hematology; (c) physiology; (d) pulmonary function and (e) histology. In the case of tumor susceptible animals, the criteria were (a) do tumors develop sooner in exposed animals and (b) do.you get more tumors in exposed animals. .2 Results EB 007141 To date the animals have been exposed only to the white mineral oil. The samples supplied by the Oil Mist Subcommittee have not been put on test at this time. A. 5.0 mg/M^ Exposure Level - The various species were e::ncsed at this level for one year- and this series has been completed, observations have been completed and results are negative. There were ho signifi cant responses or body changes at this level of exposure. B. 100 mg/M^ Exposure Level - Exposures at this level will have run two years on December 21, 1962 and the series will be terminated at that time. (a) Ir. the exposed dogs, a decrease in body weight has been r.cted in the last three months. This has not beer, seen ir. the other spe lt) :cr.ary ests, oxygen csr.surpt API 07784 I/ r,, : (o' nenatoxcgi ~3i (d) Biochemical tests show there's I loving responses: I. In hamsters ar.d rats there were nc serum changes at three norths II.. In hamsters at nine and twelve months exposure there was a ' significant increase in alkaline phosphatase activity cf the serum- After nine and eighteen months there was an increase ' in phosphatase of the iur.g tissue. - HI. Rabbits after eighteen months showed no change in phosphatase of either serum or lung tissue. ' TV. Dogs at twelve and eighteen months showed significant difference . in magnesium activated phosphatase. V. Rats at six and fourteen months showed significant increase in basic ar.c magnesium activated phosphatase of serum. Phospha tase was increased in lung tissue after one. year. (e) Pathological observations include: I. Normal macrophage activity in alveolar spaces. II. Liver, kidney, spleen, adrenal, lungs ar.d heart normal. III. Some pneumonitis ,ir. both exposed and control animals - considered not significant. . IV. Conclusion c? pathologist - no toxic effect from inhalation cf cil mist. C. . Tumor Susceptible Animals - For these studies C. f-JAX mice were used and.would be expected to develop SO-9^% rumors spontaneously in eight een months. Exposure was at 100 mg/M' with 200 experimental animals sr.d 200 controls. Exposure is new in fourteenth month. One hundred fifty animals from each group sacrificed. In exposed animals a total of 31 tumors have been observed and 30 in the controls. Hie tentative conclusion is tnat the oil'possesses no rumor 3ccelereting capacity. D. Other Comments - When the sample oils are put under test in January, the design of the study will be same as has been carried out with the mineral whize oil. Results of the studies or. white cil will be presented 3t the AIHA meeting in May ar.d then published. N V. Hendricks, Chairman EB 007142 API 07785 r= APPENDIX G REPORT OF SUBCOMMITTEE PEESICAL AGET.TS G. H. Ceilings, Jr.. >1. D , Chairman ' The Subcommittee or. Jhysica.' Agents net November 9> 1962 at the Conrad Hiltor. Hotel in Chicago with 5 members present. ' The Chairman reviewed the history of the International Standards Organization Noise Criteria and their adoption by the Subcommittee for recom mendation to the petroleum industry a year ago. Recently one of the petroleum, companies raised certain questions with respect to technical details ih these criteria and his questions vere forwarded to Dr. Glorig for answers,'both the questions and answers were read at the Subcommittee Meeting. It was requested that copies of these questions and answers be provided to the Medical Advisory Committee and technical advisors. It was pointed out that in California considerable pressure is devel oping to include loss of hearing at UOOO cps in the estimation of disability. . If this should be written into the law the ISO Standard for Noise would net be applicable. Since control of hearing less of UQOO cps would greatly increase the problem for industry and since hearing in this frequency is not related to speech the representatives of the petroleum industry are urged tc assist in any way that they can in preventing regulations of this type. The Subcommittee Chairman reminded persons present' that a summary of radiation regulations ir. the various States was recently sent -to all members with a request that it be reviewed and any changes which should be made be ' brought to the attention of the Subcommittee so that a mere complete summary . can be prepared.for distribution. " Recent developments in the fields of vibration, lighting, noise, ionizing radiation, and electro-magnetic radiation were reviewed. Specific information in any of these areas may be obtained by writ- . ing to the Subcommittee. . G. H. Coliings, Jr., M. D. , Chairman I IP> EB 007143 API 07786 T % ?.Z October 1062 ' Area 01or'.", II. D. Director cf Rancarch Cebcommittee on Nobo S27 S. Alvarado Si. Loo Angelasm 57, California Dear Dr. Glorlg: ' . ; One cf our committee membero has raised oome questions with respect to tbs use cl tbo 120 Criterion. ' I am transmitting bb questions to you with the hope that I can have 7our answers In time for discussion at our committee meeting November Sth. ' Thnr.fr you for your help with these questions. ' 1.' fn yoar opinion, chculdwe as an industry be Concerned about protecting the hearing of our employees at frequencies above 2, 000 cycles? If, In year opinion, wa should be con cerned about iho frequencies above 2, 000 cycles, what criteria or procedures chouldbs adopted In order to carry out a program of prevention? . c. All o! ycur publications and pronouncements over tbo past ten yearn have emphasised the fact Industry ahould be primarily Interested In protecting bearing In the speech . frequency ranges. Considering our major Interest b protection of hearing at audtomctrlo frequencies of 2,000 cycles down to about 530 cycles, should wa not than Ignore the hl^h frequency end of the ISO NR carves, l. e., NR 35 curve and above? 7 the high frequacct end, wa mean the Inst two octavo bands. . Jf the lent two or possibly three octave bands (mid-frequencies) of curves NR 35 and above ara not important for tbs protection of hearing In the opaecg frequencies, would ?/e net bo on firm ground to rccommond to the ISO that their standard contain n qualifying statement to this effect or possibly rocommendlrg the elimination of the high frequency portions of the curve? - .. r< EB 007144 API 07787 of cur concerns shout rctnlnlcg tbs cr-ttre.NR curve te that this curve (especially NR . ZIZ WU1 bo lifted cut of the 120 Standard and then widely quoted and used. Tears la aa ccubt that tha levels required In the upper frequency band: will represent a considerable Increase In financial outlay by our Industry should we be required to control to those levels. 3. We know that you had a major hand In the writing of ths.lSO criterion, therefore, we ere trying to resolve some differences In the ISO statements with those appearing In your nrtlele "Damage Rich Criteria and Noise Induced Hearing Lose", (Archives of Ciolaryugolgy, Oeisbor, 12C1): . ' Is your article (page 421) 70U nay: 'For habitual exposure to continuous (non-lntcrmltteat) steady celso that Is on more than five hours a day, hearing conservation .meaanrea should .to Initiated when tho sound pressure level In the octavo band whose mid-frequency Is 1,000 epa ccxcceda International Standards.Organization Noise Rating (NR) curve 85. NR curve . 05 allows the ootave band levels shown In the Table." . Our confusion here Is (a) whether we use "85 db In the 600-1,200 band" or the NR carve as the criterion. Frankly, the above quoted language allows for a very loose Interpretation end (b) the ISO usee tho sound pressure level In three bonds with mid-frequencies at.600, i,000 and 2,000 cycles and takes the highest of these to compute the noise rating number rather - than taking the sound pressure level of the band with i, 000 cycle mid-frequency as recom mended la your article.. Is there a good reason for this? ' 4. Do you have data to show that hearing loss will occur if people are expoccd to sound pxeesuro levola sillily greater than 79 db In the 8,000 epa mld-irequency band? (See ISO NH'65 curvo) if so, at what frequencies do these losses occur? . ' 5. For the rating of chort-term noise exposure, can we Ignore octave band level readings . ether than those In the 6CO-1.200 cycle band? We specifically refer to your criteria of sound pressure level In the 600-1,200 cycle band and the 12 db TTS at 2,000 ; concept. (Pfc-uro 14, Page 421 of October, 1961 article In Archlvoa of Otolaryngology). ' Verv truly yours, . Q. H. Colllags, Jr.; M. D. Chairman, Subcommittee on Phyalcal Agents t EB 007145 API 07788 G-it j27 SOUTH ALVARADO STREET. LOS ANGELES ST. CALIORNIA MUbBlN 3-9983 .. November 1, 1902 G. H. ColUngs,. Jr., M.D. Chairman, Subcosszictee on Physical-Agents American Oil Company 910 South Michigan Avenue Chicago 80, Illinois ' ` ' .. . Dear Dr. Collings, , I shali^cry and cake up die points mentioned in your letter of October 25, 1962 separately, although they overlap to some extent. . Number l regarding protecting against hearing loss above 2000 cycles, is core an academic problem than a practical one. Usually, if the noise levels in the bands 300-600,600-1200 and 1200-24G0 are low enough not to produce eke hearing loss in their respective frequencies, that is 500, 1CCC1 and 2000, chere will be ri little need to worry about frequencies on any of the points of the spectrum. ' Occasionally one does run inco some noises chat have high peaked vaLues above 2400 cycles,'but these are rare and not too large a problem. On .the ocher hand, assuming chat we do run into noises where the levels are above chose recommended in the frequencies above 2400 cycles, there is really no need to concern one- . self about this, since levels in the 2400-4600 octave band will produce losses ^ at 3000,4000 and 6C00 cycles. Usually most of the loss will occur somewhere around 400 cycles. If the states go along with Che Academy recocxnendation chat ' the impairment should be based on the three frequencies 500, 1000 end 2000 cycles, then compensation will not be a problem since losses above chat do not enter into the formula. . On the ocher hand, some states are considering using 4000 cycles. If this does occur, then it will mean that criteria will have to be completely different chan those proposed by my article as well as by the International Standards Orga nization. ' In sumary It depends a great deal on what is written Into the legislation as to whether it will be imperative to look at frequencies above 2000 cycles. For praccicle purpos.es the answer is 'no'. For legal purposes ic may be other wise. Now on question number 2. If you will read the ISO roc emendation you will find that in the hearing conservation part of it. no mention is made of the fre quencies above the 1200-2400 cycle band. This means that the shape of the curve beyond 2400 cycles is of no import for hearing conservation as far as ISO is concerned.. The reason for shaping the curves as they have been in the ISO docu ment is to allow these curves to be used for various purposes. The three main purposes are given in the docunenc: one for hearing conservation, -one for EB 007146 API 07789 )) Collings, Jr., M.D. speech communication Interference andJxhe ocher for.annoyance. 1c ' vculd be racher difficult to have curves that would be suitable for each without making thee slightly different, and thereby we have cone to one compromises in terms of the shape of these curves. Actually they leave a little to desired in that from the hearing conservation stand point the high end, chat is above 2400 cycles could scare rising or be flat, however, this would not be suitable for annoyance or communication purposes. .' * Number 3 has co do with same statement of mine in eke article, "Oarage, Risk, Criteria and Noise Induced Hearing Loss." Nov, chat I go back and read Che article over again, I can see where Che confusion mlghc arise. Actually, what was meant by the statement in Che article is that the number is assigned according co the level in the 600-1200 cycle band. This means that, whenever the noise level in one of the three bands -300-600 , 600-1200, 1200-2400 exeeds Che curve 85 which is based on. the level in the 600-1200 cycle band, hearing conservation measures should be initiated. The KR curve is the proper criterion, but in general this can be calculated by the level in the 600-1200 cycle band, since most industrial noises have a flat enough curve, or at least there are r.ot great differences between single octaves, so that if tbelevel does not exeed 85 in the 600-1200 band, Che chances of the levelcxeedlng the bands on either side very much are slim. ' In my desire to make this problem as simple as possible I have' ' taken some short cuts in my article, which ray not appear to be in agree ment with the ISO standards. One of the reasons for this is, in general, when one looks at a noise one need only look at the 600-1200 band, and make a fairly rough estimate as to whether hearing conservation is needed ' in the particular case. ' Number 4. Previous discussion has explained this, which in sunsary means, chat for conservation purposes the levels could be flat from ' .600-1200 out even rising to some extent. Number 5. Again, looking at the 600-1200 band co determine losses at 2000 cycles is more or less a practical way co consider the problem. It means, that in general, the level in the bands would not be enough higher co be more important chan the level in the 600-1200 band. Usually, industrial noises are either flat or have a 3 or 4 dB slope from low to high frequencies. This would mean Chat if the level in the 600-1200 band was 90, the chances of it being more chan a few dB higher in the ocher two bands would be rather slim. Since Che ISO curve calls for the higher EB 007147 API 07790 >) w*0 C. E. Colling*, Jr., M.D. 0. ' - level* In che 300-600 band chi* would sclll be within Che Hale* of ISO recotatendatlon. ' I.hope this clears, up che questions chat have arisen in your ' alnd and feel free to call on ae If I can give you any more information. It was good co hear from you. Kindest personnel regards. Sincerely yours, ^ (. 't ' Aram Clorlg, H.D. Director. AC/eg EB 007148 API 07791 > 4r ! | ! i' > i ' APiEmrx >: . REPORT OF SUBCOMMITTEE ON SPECIALTY PETROLEUM PRODUCTS C. H. 3aylor, M. D., Chairman Present : Excused: H. W. Gerarde, M. D. J. W. Hammond E. V. Henson, M. D. J. w. Osborn, M. D. V. w. Stewart, M. D. C. H. Baylor, M. D. - Chairman R. May E. W. Adams R. C. Cole I. Since the Subcommittee lest reported to this body, a. special meeting was held in New York City on May 9, 1962, which was attended by Dr. McKay of the University of Vermont and Dr. Mintz of the Baylor Medical School in Houston. Due to a decrease, in the number of cases of hydrocarbon ingestion 'and to the lack of a simple method' of measuring hydrocarbon levels in human blood, . both of tnese doctors recommended that their kerosine projects as such be' discontinued but requested that they be. allowed to continue the study cf cases of ingestion of mineral seal oil and liquid furniture polishes since tnese materials still carry a mortality rate up to 40$. II. The Committee reviewed and discussed the Cooperative Kerosine Study which was carried out under the guidance of Dr. Edward Press and published in the journal "Pediatrics" in April 1962. This report was informative in many respects but did not answer the basic question of the wisdom of . lavage in cases.of hydrocarbon ingestion. III. . Since the May meeting, Dr. McKay has had no cases of poisoning by mineral seal oil or liquid furniture polish but Dr. Mintz has reported five, the oldest patient being less than two years of age. Only one took more than 10 cc of the material. None died but three had fever above 101F. One was lethargic, one had diarrhea, and three had pneumonia. TVo were lavaged and one had spontaneous and induced vomiting. IV. Dr. Horace Gerarde reported to the Committee bn November 9 the results of his latest experimental work. These findings, in the opinion of the Com-' nittee, prove rather conclusively that patients who have taken small to moderate amounts of hydrocarbons should not be lavaged. In exceptional cases, especially those .who have taken larger amounts and in whom lavage appears advisable, an amount of a more viscous oil, preferably vegetable oil, should be given prior to the lavage and in- the same amount at least as "she ingested material. . If some of the material is then aspirated during lavage. Dr. Gerarde has shown it to be essentially harmless. O* in V. The Commi tee recommends that the kerosine project be discontinued : *> * entirety per. the exhaustion cf its present funds. The proposal is base or. z z lowing reasons: ' EB 007149 API 07792 r ) -n H-2 Dr. Gerarde has answered to the satisfaction of the Committee the fundamental question for which the project was planned. The Committee anticipates 'fewer cases of poisoning due to several factors including publicity given to reported cases and various educational programs, e.g.. Poison Prevention Week and the efforts of the Poison Control Centers. VI. In the meantime, Dr. Mintz has requested $1,725 to carry on his study of furniture polish cases until May 19$*. The Committee dj.d not fore see this need.at the time of the last appropriations b\it somewhat more than :kis sum was held as unused funds by Dr. McKay. After consultation with Mr. Mattocks and Dr. Balph Schneider, the Chairman wrote a .letter of explanation to Dr. McKay and requested the return of $2,000 to the API. Dr. McKay willingly agreed to this. The Committee now requests the approval-.of this body to transfer these funds to the account of Baylor University for use by Dr. Mintz. VII. The Committee .requests Dr. Gerarde to submit his experimental results ' to the Association of Poison Control Centers for distribution to its members throughout the Country and to the "Journal of the American. Medical Association." We understand they are to be published in the "Archives of Environmental Health" but feel they should have wider dis tribution. - VIII. The Committee maintains a membership in the Association of Poison Control Centers, primarily for obtaining information. Dr. E. V. Henson of the Committee attended the annual meeting in Chicago last month and reported . to the Committee. (See Appendix) IX. The Committee recommends participation by the API in "Poison Prevention Week." X. Incidentally, a court case (Spruill vs Boyle - Midway Inc. - Fourth ' Circuit Court - Va. - 196l) has come to the attention of the Committee. A family was awarded $20,000 in damages following the death of a child who drank furniture polish. Apparently, weight was given by the Court to the fact that the company was aware of 32 cases of poisoning by the same product since 1953* Ten of these cases were fatal. ' . EB 007150 API 07793 r > H-3 APPENDIX REPORT TO THE COMMITTEE OF DR. E. V. HENSON 1. The American Association of Poison Control Centers, held its annual meeting . in October 19^2 in conjunction with the Academy of Pediatrics. They have met with the pediatricians for several years but in the future may hold their meeting with the American Medical Association or the Academy of General Practice. 2. . The Food and Drug Administration, between June 1961 and June 1962 made 1,185 inspections and 17 seizures for improperly-labeled carbon tetra chloride, sulfuric acid, zinc chloride solder flux and turpentine, but no petroleum products. . 3. There have been 111 requests for exemption to the labeling laws, primar ily for waxes and paints. U. Regulations for benzine, tolune and xylene are due soon. . I5. Dr. Edward Press made a report on the Cooperative. Kerosine. Study, published in "Pediatrics" - April 1962. ' '. . 6. New posters have been printed for "Poison Prevention Week". The Associa tion expects more active support of its 1963 program. . 7. Much concern was expressed by some members over the possibility of the Poison Control Center's being sued for advice given oyer the telephone. . They decided,- however, to continue their present method of operation for the present. ` ' .. . 3.` There was a long discussion of the' recent salt poisoning cases among infants in a Binghamton, N. Y. hospital. 0 66 007,s, API 07794 APPENDIX I REPORT OF SUBCOMMITTEE ON TOXICOLOGICAL REVIEWS H. W. Gerarde, M. D., Chairman ~ The subcommittee met in Private Dining Room 19 in the Conrad Hilton Hotel, on Friday afternoon, November 9> 1962. A number of guests vere present in addition to members of tne sub committee . Since the April meeting, toxicological reviews have been published on Styrene, Cyclohexane, Sulfur Dioxide and Sulfuric Acid. Hie subcommittee is currently preparing drafts on Aromatic Petro leum Naptha, Cumene, and Kerosine for distribution to members of the Medical Advisory Committee. Professor Drinker will be asked to prepare a toxicological review on gasoline. The subcommittee requests that the AH pay him in advance for his services. The chairman and one or more members of the subcommittee will personally call on Dr. Ralph Smith, of Wayne University, to discuss his pro posal that Gasoline, Stoddard Solvent and Petroleum Naphtha be defined and listed as petroleum distillates in the ACGIH MAC tables. The subcommittee felt that the term "Petroleum Distillate" was not in common use outside of the petroleum industry. The list of petroleum dis tillates with various distillation ranges and aromatic content is large and hence its use would create more misunderstanding and confusion than the pres ent classification and terminology. I move the adoption of this report. H. W. Gerarde, M. D., Chairman .. API 07795 APPENDIX J REPORT OF TEE INTSP-DIVISIOEAL COMMITTEE ON ASPHALT ' 10 THE GENERAL COMMITTEE, DIVISION OF SCIENCE AND TECHNOLOGY J. A. Spence, Chairman In late 1961, the Medical and Health Committee of the Board of Directors approved the creation of the Interdivisional Committee on Asphalt to deal with matters relating to health hazards. To this committee, Mr. C. E. Spehr appointed 13 members, representing asphalt manufacturing., marketing, and research groups, and the Central Committee'on Medicine and Health. Ihe first committee meeting was held November 9, 1962* in Chicago. Ihe scope and purpose of the committee is to keep abreast of and investigate all developments relating to health hazards of asphalt and to' advise on any significant activity in this area. This would include epidemi ological, toxicological, and analytical problems. Close liaison with the U. S. Public Health Service and others interested in asphalt will be main tained. Ihe chairman reported on the biological research in progress at the California College of Medicine under a National Institute of Health grant. A composite sample of steam refined and air blown asphalt has produced cancer when applied repeatedly, using benzene diluent, to the skin of mice or when injected subcutaneously. Further studies including inhalation are in pro- . gress and the committee will continue to .follow this work. Ihe committee plans to contact the U. S. Public Health Service Taft Sanitary Center,-so as to offer assistance and folic--- the work being done on their Carcinogen Appraisal Study. Ihe Center is seeking to identify sources emitting carcinogens as'air pollutants. Asphalt refining as well as its use in roofing and road making are being investigated. At the chairman's invitation. Dr. A. W. Horton of the Kettering Laboratory reviewed for the committee his work on the carcinogenic activity of petroleum and coal tar stocks. He sought to identify the components of asphalt to be suspected and pointed out possible methods of evaluating potential hazards if existent. The committee agreed that four areas will require attention: (l) Selection, Identification, and Analyses of Asphalts, (2) Biological Testing, (3) Evaluating Environmental Exposure, and (4) Epidemiology. Com mittee members will be appointed by the chairman to coordinate each area. Ihe next meeting of the committee is planned tentatively for the spring of 1963. J. A. Spence, Chairman November 12, 1962 EB 007153 API 07796 V "> >.7?nzzy. X HUMBLE OIL & REFINING COMPANY HOUSTON l TEXAS MCOICAU DC^AATMCHT v.MeM. iKaAiikioV,IRmfl.CoT.Oa * ROMtCOKTIAT.1WH|iWll.<M*k.O0..*rC.CAt%.CA.r. MAAVCT INVMI, M.O. MMCMfl MWk l*UfM H.cT.cCrMmOInCMtiAiwAOfT. MA., 'f.AX.R. C.HMiViia*TiCmfMOMTOOMCmr. M.. a. M. ADAM*, M.o. September 216* 1962 J !1 Mr. Quincy V. Tuma Texaco Inc. ' P. 0. Box 2332 Houston 1, Texas . . Dear Mr. Tiuna: . . Enclosed is a copy of an editorial concerning the benefits and hazards of a closed chest method of cardio. pulmonary resuscitation. As you can see* this has been adopted as the current stand taken by the American Heart . Association, Inc.* the American National Red Cross* and the Industrial Medical Association. s ' To me* it seems very sound and the emphasis should be on training physicians, nurses* and especially qualified emergency rescue personnel in the proper method of applying this type of emergency procedure. '' . . j j If a new first aid manual were to be printed, the section on mouth-to-raouth resuscitation as found in the American Medical Association's first aid manual could be included in the new edition. Since a new edition is not planned in the immediate future, we will have time to form additional opinions on the closed chest cardiac massage question. ; Dr. Ralph Schneider has ottered the opinion that closed chest cardiac massage should not be included in the first aid manual unless the mouth-to-mouth resuscitation procedure was also included. In my opinion, we could do the converse and include the mouth-to-mouth resuscitation procedure with out the description of closed chest cardiac massage. If I can be of further assistance, please let me know. .. 1*1 Very truly yours, t *' . '. . * IIARVEY B. SNYDER, M. D. EB 007154 HBS:sp . cc: Dr. R. F. Schneider Mr. J. W. Hammond A API 07797 ) -2- K-2 EDITO RIAL The Closed Chest Method of Cardiopulmonary Resuscitation " Benefits and Hazards . In view of the growing interest in the closed chest method of cardio pulmonary resuscitation, and the possible dangers in its indiscriminate use, the following statement has been prepared as a guide to the public regarding the'present place of'this new technique. . The closed chest method of cardiopulmonary resuscitation has beer.' proved effective as a medical procedure in certain cases of stoppage or dis ruption of the heart beat. However, it is to be considered a temporary method and additional medical treatment, which, may include the use of drugs and an electric defibrillator, is usually required to restore the circulation per manently. The heart best may stop as a result of a variety of conditions or ' circumstances such as water submersion, electrical shock, asphyxiation, heart attack, or during anesthesia or surgery. Most people who experience sudden stoppage or disruption of the heart beat (cardiac arrest) cannot be saved even under ideal circumstances in a hospital. The least measure of success has been ' experienced in coronary heart "attack" cases. However, the prompt use of car diopulmonary resuscitation has enabled lives to be saved which previously might have been lost. The new technique of closed chest cardiac massage-makes it ' possible to continue blood circulation without opening the chest, thus greatly extending the possibilities for attempting saving of life. Consequently, it is the desire or all concerned to achieve widespread use of this method where it can be used safely and effectively. ' The public should be advised, however, that the application of closed chest cardiopulmonary resuscitation calls for a working diagnosis of the victim's condition. It is important to be sure that the circulation has actually stopped because the method involves certain hazards. Reported injuries to patients have included damage to the heart and liver, internal bleeding, multiple rib fractures, and puncture of the lungs. In untrained hands the risk of injury is increased. It is particularly important to avoid the possibility of inflicting serious injury on a person under the mistaken impression that cardiac arrest has occurred when the individual has simply fainted or lost consciousness from some other cause. Successful application of closed chest cardiopulmonary resuscitation depends on thorough and careful training. One is most unlikely to be able to achieve artificial blood circulation by this method if his only training is from reading written instructions. In view of these facts, it is suggested that closed chest cardiopul monary resuscitation be applied only by carefully trained personnel so that it may be utilized with the greatest safety and effectiveness. Two qualified per sons are preferable because it is necessary to maintain artificial respriation at the same time the heart is being massaged externally. A decision as to whether training in this procedure snould be extended to certain sener.ts of the general public must be postponed until further experience accumulates. EB 007155 API 07798 )) 3- K-3 The undersigned organizations Joining in this statement believe that urShould be placed at this time on training physicians, dentists, nurses, specially qualified emergency rescue personnel so that the procuedure will t more widely available. " - American Heart Association, Inc. American National Bed Cross Industrial Medical Association . .' . . Circulation, Volume XXVI, September 1962 324 EB 007156 Apj 077ss FROM: JAMA, Scptmbr IS, IS62 K-h 4 '! 1 r--------- :---------------------------- :------------------- \ Amateurs Should Not Try External Heart Massage Closed-chest cardiac manage ihould only be pa(armed by trained indi vidual], according to the American Heart AnodaUon, the American Bed Cnee and the Industrial Medical AnodaUon. '. ' In a joint statement, the three organizations noted that: *The daeed ' cheat method of cardiopulmonary resuscitation baa been proved effective as a medical procedure in certain cases at stoppage or disruption of the heart beat. However, it is to be considered a temporary method and additional medical treatment, which may indude the use of drugs and an electric defibrillator, is usually required to restore the circulation permanently. "The heart beat may atop as a result of a variety of conditions or circum- . stances such as water submersion, electrical shock, asphyxiation, heart attack, or during anesthesia or surgery. Most people who experience sudden cardiac arrest cannot be saved even under ideal circumstances hi a hospital. The least measure of success has been experienced hi coronary bent 'attack* cases. However, the prompt urn of caidiopuhnonary resuscitation has enabled lives to be saved which previously might have beau lost The new technique of closed chest cardiac massage makes K passible to con tinue blood circulation without opening the chest, thus greatly extending the possibilities for attempting saving- of life. Consequently, It ii the desire . of all concerned to achieve widespread on of this method where It can be used solely and effectively. '. "The public should be advised, however, that the application of dosed chest cardiopulmonary resuscitation calls for a working diagnosis at the victim's condition. It is important to be sure that the circulation has actually stopped because the method involves certain hazards. Reported injuries to patients have included damage to the heart and liver, internal bleeding, multiple rib fractures, and puncture of the hmgr. - "In untrained bands the risk of injury is increased. It is particularly Im portant to avoid iba possibility of indicting serious injury on a person under the mistaken fanpramIon that cardiac urest has occurred when the indi vidual has simply fainted or lost ooosoiousness from some other causa. "Successful application of dared chest cardiopulmonary resusdtatioo depends on thorough and careful training. One Is most unlikely to be able to achieve artificial blood circulation by this method if his only training is from reading writlan instructions. ' "la view of there facts, it is suggested that dosed chest cardiopulmonary resusdtatioo be applied only by. carefully trained personnel so that ft may be utilized with the greatest safety and afisettvsness." .The organizations added that "emphasis should bo placed at this tfae on trsiniog physicians, dentists, nurses and specially, qualified smsrgsnur rescue- pereonnd so that the- procedure- will became-mors-widely available. V______________________ _________________________ EB 007157 API 07800 ) Benefits and Hazards of Closed-Chest Cardiac Message This revision oi th Amsricon Heart Association's statamont on llt closedcKest method of cardiopulmonary re suscitation is endorsed by the Indus trial Medical Association, the Amer ican Heart Association, and the Amer icon Natioapl led Cross. In VIEW of the growing interest in the closed-chest method ol cardio pulmonary resuscitation, and the possible dangers in its indiscrimi nate use. the following statement has been prepared as a guide to the pi'Mic regarding the present place of this new technique. The closed-chest method of cardi opulmonary resuscitation has been proved effective as a medical pro cedure in certain cases of stoppage or disruption of the heart heat. However, h is to he considered a temporary method and additional medical treatment, which may in clude the use of drugs and an elec tric defibrillator, is usually required to restore the circulation perma nently. The heart heat may stop as a re sult of a variety of conditions or circumstances such as water sub mersion, electrical shock, asphyxia tion. heart attack, or during anes thesia or surgery. Most people who experience sudden stoppage or dis ruption of the heart heat (cardiac arrest | cannot he saved even under ideal circumstances in a hospital. The least measure of success has been experienced in coronary heart "attack" eases. However, the prompt use of cardiopulmonary resuscita tion has enabled lives to be saved which previously might have been lost. The new technique of closedchest cardiac massage makes h possible to continue Wood circula tion without opening the chest, thus greatly extending the possibilities for attempting saving of life. Conse, quentiy. h is the desire of all con cerned to achieve widespread use of this method where it can he used safety and effectively. The puWic should he advised, however, that the application o( closed-heart cardiopulmonary resus citation calls ftir a working diagnosis of the victim's condition. It is im portant to he sure that the circula tion has actually stopped because the method involves certain hazards. Reported injuries to patients have included damage to the heart and liver, internal Weeding, multiple rib fractures, and puncture of the lungs. In untrained hands the risk of injury is increased. It is particularly im portant to avoid the possibility of inflicting serious injury cm a person under the mistaken impression that cardiac arrest has occurred when the individual has simply fainted or lost consciousness from some other cause. . . Successful application of ckncd- chest cardiopulmonary resuscitation depends on thorough' and careful training. One .is most unlikely to be hie to achieve anifical blood cir- cvlstica by this method if his only training is from reading written instructions. '. In view of these facts, it is sug gested that closed-chest cardio pulmonary resuscitation be applied only by carefully trained personnel so it may be utilized with the great est safety and effectiveness. Two qualified persons arc preferable be cause It is necessary to maintain artificial respiration at the same lime the heart b being massaged exter nally. A decision as to whether training in this procedure should be extended to certain segments of the general public must he postponed until further experience accumu lates. The organizations 'joining in this statement believe that emphasis should he placed at this time on training physicians, demists, nurses, and specially qualified emergency fescue personnel so the procedure will heepme more widely available. Reprinted from Ihe September. 1W>2 nnuc of the /imrmd of Orrapaliooul klnlkimr. . . EB 007158 API 076oi si APPENDIX L REPORT OF THE ::iT5RDIVISI0IIAL COMMITTEE ON LABELING Allan E. Dooley, Chairman The Food and Drug Administration has not acted on the API proposal that petroleum distillates with viscosities above ^5 SSU at 100F be exempted from the labeling requirements of the Federal Hazardous Substances Labeling Act insofar as they relate to the hazard of aspiration. Work on the revision of Bulletin 2511 has been held up pending the FDA decision. The Federal Act becomes fully effective on February 1, 1963 a_t which time all present extensions regarding type size, location and wording of the precautionary wording will terminate. Under the Federal Act, FDA inspectors have the authority to make plant inspections. A few such inspections have already been made of oil company plants. The Interdivisional Committee on -Labeling suggests that . the individual oil companies advise their personnel concern of the likeli hood of such inspections. The FIA is expected to issue shortly a new regulation requiring the precautionary labels for benzene, toluene and xylene to Include reference to the aspiration hazard of these substances. Allan E. Dooley, Chairman API 07802 APPENDIX M REPORT CN LIAISON WITH NATIONAL POISON PREVENTION WEEK TO MEDICAL ADVISOR! COMMITTEE Following the April 1962 Spring Meeting of the MAC, the General Con- mittee of the Division of Science and Technology recommended and the Board of Directors' approved, the API's participation in National Poison Prevention Week for 1963. '. . J. W. Osborn, M. D., was designated by the Chairman of the MAC as the official liaison between the API and the Steering Committee for National Poison Prevention Week. Hie General Committee's recommendation to the Board of Directors included a request that the Committee on Public Affairs and the Fire and Safety Committee assist in promoting National Poison Prevention Week for 1963. On May 2 Mr. Mattocks wrote to Mr. John Bivins, Director, Committee on Public Affairs, and to Mr. J. Howard Ityers, Chairman, Fire and Safety Com mittee, informing them of the Board of Directors' request. - In July, Mr. Wally West, of the staff .of the API Committee on Public Affairs, prepared a "National Poison Prevention Week Article for Oil Features" to go to editors Of the various oil company house organs for their considera tion for publication. No word has been received to date from the Chairman of the Fire and Safety Committee .regarding that committee's interest in this pro gram. ' ' On August 2 Dr. Osborn, through Mr. Mattocks' office, distributed to all members and technical advisors of the MAC copies of his company's house organ containing another article on this subject, "Keep Your Home Poison-Safe." . Hie following actions and events have occurred since last April re garding the organization of National Poison Prevention Week for 1963: On May 10 representatives of fourteen national organiza tions met in Washington to discuss the report of the 1962 observance and to initiate plans for 1963. It was decided to establish a National Planning Council to sponsor National I Poison Prevention Week. The API was invited to become a mem ber of this Planning Council. A tentative budget of $3000- $7000 was set up. Hie API designated Dr. Osborn to represent : it on the Planning Council with Mr. Mattocks as alternate. Hie API subsequently contributed $500 to this budget. On September 5 Dr. Osborn attended the first meeting of the Planning Council in Washington. Hie following officers were elected: Chairman - Dr. Edward Press (Representing American ' Academy of Pediatrics and American Public Health Association) Vice Chairman - Dr. James W. Osborn (Representing American Petroleum Institute) Secretary - Mr. Henry L. Verhulst (Representing U. S. Public Health Service) Treasurer - Mr. Robert M. Oswald (Representing . EB 007160 American National Red Cross) API 07803 -2 - M-2 The newly elected officers, together with the former Steering Committee, r.ow constitute the Executive Committee of the National Planning Coyncil for National Poison Preven tion Week. At the September 5 meeting, a proposed program of activ ities for 1963 was discussed. The Mson Control Branch, U.S. Public Health Service, will prepare and distribute radio and television announcements and television slides and prepared addresses. Proclamations for use by governors and mayors,- stationery, window streamers, editorial fact sheets and lists of materials available for use during the 1963 Week will be prepared and- distributed by the American Riarmaceutical Asso ciation. ' As of September 5, financial contributions for activities other than those listed above had been received, or committed, totaling $2300. Hie Planning Council agreed that this $2300 should be used for a newspaper 8d mat ($1500), additional window streamers ($500) and a reproduction proof for a flyer ($300). ' ' December 1, 1962, was set as the deadline for reporting items to be included on the -List of Materials available and the materials themselves are to be available no later than February 1, 1963. The American Association of Poison Control Centers pre- sented photographs of suggested exhibit material which that association-could make available under its own budget. Hie Planning Council reacted favorably to the suggestion and so advised the chairman of the Committee on Education of that association. . By January 1, 1963, a List of Materials will be published, indicating the various resources and items available to-initiate local programs for the second annual observance of National Poison Prevention Week, March 17-23, 1963- This list will be obtainable by writing to: . . Mr. Henry L. Verhulst, Secretary . National Planning Council National Poison Prevention Week c/o U.S. Public Health Service Washington 25, D. C. The API member companies are urged to avail themselves of the List of Materials and to publicize its availability through whatever means of communi cation each company deems best. . J; W. Osborn, M. D. EB 007161 API 07804 k APPENDIX N REPORT OF THE INTERSIVISIONAL COMMITTEE ON PETROLEUM FOOD ADDITIVES TO THE ' '! GENERAL COMMITTEE, DIVISION OF SCIENCE AND TECHNOIOGT ' L. E. Curtis,...M. D., Chairman . The Interdivisional Committee on Petroleum Food Additives held its Fifth Meeting on November 9, 1962. Dr. G. W. Fiero, Chairman of the Subcom mittee on White Oil, reported on the three petitions for approval by the FDA, namely, FAP 302 - White Mineral Oil - FDA filing date March 11, 19*51, FAP 323 Technical White Mineral Oil - FDA filing date March 17, 1961, and FAP 42$ Odorless Light Petroleum hydrocarbons - FDA filing date March 21, 1961. These appear to have a fairly good chance of being approved. As a matter of fact, it was expected that a regulation on FAP 302 will be issued in early 1963. ' There has been some concern among the oil company analysts as regards the dimethyl sulfoxide test because of technical problems. However, the FDA seems to be adamant that tills test will be included in the regulation. ' All biological studies on petrolatum have now been completed and the final report from'the Food and Drug Research Laboratories, Inc. is ex pected in two or three weeks. As soon as this is received, a petition will be prepared for presentation to the. FDA and at the same time, a further ex tension of time will be requested inasmuch as the current extension expires December 31, 1962. All of the feeding and subcutaneous tests have produced negative tests with respect to carcinogenicity or toxicity. The committee additionally decided to prepare write-ups on those petroleum products which will have approval by FDA and present these write ups to the "Food Chemicals Codex," which is being prepared by the National Academy of Sciences - National Research Council. L. E. Curtis, M. D., Chairman .icvesre; 1 EB 007162 API 07805 N REPORT OF LIAISON WITH QUARANTINE SERVICE TO MEDICAL ADVISORY COMMITTEE APPENDIX 0 Liaison with the Epidemiology and'Domestic Operations Branch, Divi sion of Foreign Quarantine'of the U. S.. Public Health Service, has continued. Since the last report to the Medical Advisory Committee on the 9th of April, ' .1962, there have been numerous communications from the Branch concerning primarily Smallpox, Cholera, Poliomyelitis and Typhoid. Some of this infor mation vas passed on to the Medical Advisory Committee -- some was not. . Smallpox The previous report to the MAC summarized the information concern- . . ing the outbreak of Smallpox in Western Europe until that time. Information received subsequent to that meeting indicated that between the period December, 1961 through April, 1962 there were seven separate importations of Smallpox into Western Europe (England and Germany), with a total of 107 cases reported, with 29 deaths. It was not until May 29, 1962 that .the toited Kingdom was reported free of Smallpox and this was the last infected area in Western Europe.. On the 6th of April, 1962, the U. S. Public Health Service reported that Smallpox had occurred in Gdynia, Poland. A man arrived from India on March 3rd and a diagnosis of Smallpox was made on March 20th. By the 6th of April there were three secondary cases reported. On the 9th of May, 1962, the U.S.P.H.S. reported that Ibland, the Port of Novay, near Danzig, was declared a local infected area for Smallpox. . On the lth of October, 1962, the U.S.P.H.S. reported that there was . a suspected case of Smallpox in Vancouver, British Columbia, in a student, at the University of British Columbia who had arrived in Vancouver on the 21st of. September, 1962 from Bangkok via Hong Kong and Tokyo. Ke was taken ill a few days after arrival but he was not seen by a physician untii the first of October when he presented a. generalized crusted rash and he was hospitalized with a preliminary diagnosis Of Smallpox. There were 139 passengers aboard . the aircraft on which he arrived, 39 of whom were bound for the United States -- their final destination unknown. Laboratory studies, which were carried out or. this case, were reported to us on the 8th of October, 1962, by the Quarantine Service of the U.S.P.H.S., as negative. The final diagnosis, however, was not given. Cholera On June 1st, 1962, a memorandum was issued by the U.S.P.H.S. which stated that the World Health Assembly, in May, 1962, recommended that Cholera due to El Tor vibrio be included among the regulations concerning Cholera and that beginning with the week of May 22nd, 1962, parts of the Philippines and North Bornea be Included in infected areas; further, that persons going into these areas should be advised to be vaccinated against Cholera and that a valid certificate would be required of persons arriving in the United States within five days after leaving the designated areas. On July 20th, 1962, the presence of Cholera was confirmed in Taiwan, in the Prefectures of Chiayi, Tainar. and Yunlin and on August 6th, 1962, Cholera was'reported unofficially in Japan. EB 007163 API 07806 Typhoid ` On the Uth of June, 1962., the U.S.P.H.S. reported that there had been an epidemic of Typhoid in San Salvador since January with the following number of cases reported by months: ' .' - January February March April' 15 53 96 122 The epidemic was said to have been caused by ice cream. No further reports have been received to date.. Poliomyelitis On April 10th, 1962, the U.S.P.H.S. reported that they had been in formed of a case of paralytic Poliomyelitis in a U.S. seaman in Calcutta, India who had not been vaccinated previously. They also reported that there had been three other known cases of Polio in that, area during the previous year among the European colony and it was recommended that all foreign travel lers be given immunization against. Polio as well as against Smallpox, Tetanus and Typhoid, and others, as indicated in the booklet, IMMUNIZATION INFORMATION FOR INTERNATIONAL TRAVEL. In this- connection, there is now available a new edition of this booklet as revised in June, 1962: . Public Health Service Publication No. 3S1* For Sale by the Superintendent of Ducuments, U.S. Governmen Printing Office, Washington 25, D.C.-- Price 35 Cents . George M. Saunders, M. D. EB 007164 \ appendix p REPORT CF THE ADVISORY COMMITTEE TO THE VAX RESEARCH P5CJSCT TO THE JENERAL COMMITTEE, DIVISION OF SCIENCE AND TECHNOLOGY R. E. Eckardt, M. D., Chairman -4 A petition was filed with the Food and Drug Administration of the Department of Health, Education, and Welfare, on June 4, 1962, to permit the use of petroleum waxes as food additives: , as a direct food additive in chewing gum and other confections, an anti-frothing agent in sugar and for the waxing of fruits and vegetables; and b, as an indirect additive in or on mater ials used in producing, manufacturing, packing, processing, preparing, treating, packaging, transporting, or holding food. This petition was subsequently amended on June 19 and June 22. Subsequently, the FDA indicated they wished additional information. Following a conference, Mr. Porter supplied, on October 2nd, the additional information requested and filed two additional amendments to the petition. The petition was formally filed September 27, 19^2. It is hoped that within a reasonable length of time a regulation will be issued permitting the use of petroleum waxes as food additives. The petition is based on experimental work done by the Chicago Medical School, under the direction of Riilippe Shubik, M. D. $523,000 has been spent so far. While there is still a small amount of biological research being done by the Chicago Medical School as a follow-up, essentially, the investigational work is completed. No money was requested for 1962. . R. E. Eckardt, M. D., Chairman November 12, 1962 API 07808 1 4 V. . APFEZSIX Q REPORT OF TEE MEDIC.-.L AEVISOHf COMMITTEE TG THE GENERAL COMMITTEE, ZETISZCi: CF SCIENCE AID TECHNOLOGY R. F. Schneider, M. D., Chairman The Medical Advisory Committee is concerned with the aspects of the petroleum industry's products and processes as they relate to the health of its employees, its customers, and the public. This requires understanding of the possible toxicity of the various raw materials and finished products of the petroleum industry. Specific aspects of the health problems are assigned to a number of subcommittees. One of the more important problems today concerns atmospheric pollu tion. The possible health effects of polluted air is growing in importance in the minds of the public and government and is continuing to receive a greater proportion of the attention of the petroleum industry's physicians. Based on recommendations of the Subcommittee on Atmospheric Pollutants, a research pro ject was initiated January 1, 1962 at the Chicago Medical School to study the toxicity of aromatic hydrocarbons in lungs. Although a great number of claims are made, practically no scientific data exists to directly associate aromatic hydrocarbons with cancer formation in the lungs. It will be necessary to con tinue this project at least through 1963* A project was initiated in 1955 to study the C9 - C}2 aromatic hydro carbons. With the increased aromatic content of gasoline, it was necessary to have a better knowledge of the toxicity of these compounds. This project was completed this year. Starting in 1953, grants of money were given to Baylor University, the University of Vermont, and :he University of Texas Medical Schools to determine the effect of swallowing light petroleum products, especially kerosine. At Baylor University ana the University of Vermont, effort was made to study the effect of removing the petroleum product from the patient's stomach in one case while, in another case, leaving the petroleum product in the pa tient's stomach and keeping the patient quiet so it would not vomit. The Uni versity of Texas was endeavoring to determine what the effect would be on ani mals of permitting kerosine to pass through the intestinal system. With the decreasing number of kerosine poisoning cases, undoubtedly as the result of national educational programs in the field of safety and safe uses of substances, the work at Baylor University and the University of Vermont has diminished to an insignificant amount. The attention of these investigators is currently be ing devoted to other petroleum products. The work at the University of Texas on animals has been discontinued. The Subcommittee on Toxicological Reviews continues to be quite active in the issuing of revised toxicological reviews, likewise, they are working on the issuing of new toxicological reviews on petroleum products. The committee continues to support research of the Subcommittee on Noise of the Committee on Conservation of fearing of the American Academy of Ophthalmology and Otolaryngology. This permits the physicians to keep actively informed of the new work on the effect of noise on employees and to evaluate the effect of petroleum processes noise on the health of the workers associated with these processes. API 07809 -2- Q-2 Hie possible effect on employees inhaling oil mist over an extensive period of time is being studied. Effort is being made to interest a company who has considerable data about its employees who have been thus exposed to oil mist over an extensive period of time to publish their data. Through active cooperation with the Quarantine Service of the Public Health Service of the United States Government, the physicians are informed of the existence of contagious diseases throughout the world. This assures that petroleum employees traveling world-wide have the proper up-to-date innoculations. The Medical Advisory Committee is finding that the health problems of the petroleum industry are increasing and is endeavoring to actively keep abreast of them. R. F. Schneider, M. D., Chairman November 12, 1962 API 07810