Document 2RZe5LdDwbraJJK8ejXoe4KJg

ATTACHMENT TO LETTER OF JUNE 28, 2001 BACK TO COMPOUNDS 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE DOCUMENTS Click on Study Title to View Report COMPOUND-SPECIFIC STUDIES PFOS Perfluorooctane Sulfonate Repeat Dose Studies 1. Exploratory 28-day Oral Toxicity Study with Telomer Alcohol, Telomer Acrylate, [redacted confidential business information], PFHS and PFOS (positive control) by Daily Gavage in the Rat Followed by a 14/28-Day Recovery Period, NOTOX Project 242933, 3M Ref. No. T-7023, 7024, 7022, 7032, 6295, April 28, 1999 Note: This study was previously submitted by letter dated May 15, 2000. Because it contained confi dential business information, it was not included on prior CDs. We have included the redacted copy of the study on this CD for the convenience of electronic users. 2. Letter from 3M to TSCA 8e docket dated May 24, 2001, re TSCA 8e Supplemental Risk Notice: Potas sium Perfluorooctane Sulfonate, reporting preliminary statistical findings of the 104-Week Dietary Chronic Toxicity Study with Perfluorooctane Sulfonic Acid Potassium Salt (PFOS T6295) in Rats (Covance Study No. 6329-183) Note: As more fully described in the cover letter for this June 28 document submission, further pa thology review of this study is continuing, and the full study report is therefore not yet available. The letter submitted here presents only the statistical findings, without evaluation of their potential biological relevance. Teratology/Reproductive 1. To accompany Argus in-life study entitled Oral (Stomach Tube) Developmental Toxicity Study of PFOS in Rabbits, Argus Research Laboratories, Inc., Sponsor's Study No. 6295.10, January 11, 1999, previously submitted April 21, 2000: Analytical Laboratory Report, Determination of the Concentration of Potassium Perfluorooctanesul fonate (PFOS) Fluorochemical in Rabbit Liver and Serum Specimens, 3M Environmental Laboratory Report No. TOX-099, Laboratory Request No. U2400, 3M Ref. No. T-6295.10, February 9, 2001 ATTACHMENT TO LETTER OF JUNE 28, 2001 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE DOCUMENTS Click on Study Title to View Report COMPOUND-SPECIFIC STUDIES PFOS Perfluorooctane Sulfonate Mechanistic/Pharmacokinetic: 1. To accompany in-life study entitled Final Report, Oral (Gavage) Pharmacokinetic Study of PFOS in Rats, Argus Research Laboratories, Inc., Sponsor's Study No. T-6295.12, Protocol 418-013, June 24, 1999, sub mitted April 20, 2000: Analytical Laboratory Report, Determination of the Presence and Concentration of Perfluorooctanesulfonate (PFOS) in the Serum, Liver, Urine, and Feces of Crl:CDBR VAF/Plus Rats Exposed to PFOS via Gavage, 3M Environmental Laboratory Report No. TOX-110, Laboratory Request No. U2849, 3M Ref. No. T-6295.12, May 4, 2001 (includes serum analyses from Advanced Bioanalytical Services, liver analyses from Battelle Memorial Institute, feces analyses from Centre Analytical Laboratories and urine analyses from 3M Environmental Laboratory) 2. To accompany in-life study entitled Final Report, Oral (Gavage) Pharmacokinetic Recovery Study of PFOS in Rats, Argus Research Laboratories, Inc., Sponsor's Study No. T-6295.14, Protocol 418-015, July 23, 1999, submitted April 20, 2000: Analytical Laboratory Report, Determination of the Concentration of Perfluorooctanesulfonate (PFOS) in the Serum, Liver, Urine, and Feces of Crl:CDBR VAF/Plus Rats Exposed to PFOS via Ga vage, 3M Environmental Laboratory Report No. TOX-111, Laboratory Request No. U2994, 3M Ref. No. T-6295.14, May 4, 2001 (includes serum analyses from Advanced Bioanalytical Services, liver analyses from Battelle Memorial Institute, feces analyses from Centre Analytical Laboratories and urine analyses from 3M Environmental Laboratory) 3. Letter from 3M to TSCA 8e docket, March 28, 2001, re TSCA 8e Supplemental Submission: Docket 8eHQ - 998-374 Perfluorooctane Sulfonate (PFOS), reporting results of mechanistic study to elucidate two-generation study, evaluating effects of mevalonate cholesterol supplementation and potential thyroid effects 4. Solubility Study of Perfluorooctanesulfonate (PFOS), SD-018 and Perfluorooctanesulfonamide (FOSA), SE-027 in Male/Female Urine, 3M Environmental Laboratory Project No. E01-0768, June 4, 2001. 5. Summary of Naive Rat/Rat Chow/Fish Meal Study Analyses Conducted by the 3M Environmental Lab (prepared 03/01/01). 6. Final Report - Analytical Study, "Covance Laboratories Contamination Testing," 3M Environmental Labo ratory ET&SS Study No. FS-980618-1, 3M Reference No. T-6316.9 Human Sera/Medical Surveillance/Epidemiology 1. Letter from 3M Medical Director Larry R. Zobel, M.D., M.PH., to Charles Auer, USEPA, April 25, 2001, reporting on status of study of 3M retirees and associated calculation of the half-life of PFOS in serum